In this account, we will highlight recent progress in the development of multichannel lanthanide-doped (MC−Ln) nanoprobes for highly efficient serodiagnosis and therapy, with a particular focus on our own work. First, we first provide a classification of the types of MC−Ln nanoprobes based on the contained type and number of signals. The merits of different types of nanoprobes and the reason using lanthanides are elucidated. Then, we provide an overview of the current uses of MC−Ln nanoprobes in serodiagnosis and therapy, focusing on the strategic exploration to improve the diagnostic and therapeutic performance from different perspectives. Finally, we present a prospective outlook on the future development and potential issues of next-generation MC−Ln nanoprobes. We hope that this timely account will update our understanding of MC−Ln and similar nanoprobes for bioapplications and provide helpful references for the state-of-the-art tools for serodiagnosis and therapy.
{"title":"Multichannel Lanthanide-Doped Nanoprobes for Serodiagnosis and Therapy","authors":"Dr. Yuxin Liu, Zheng Wei","doi":"10.1002/tcr.202400100","DOIUrl":"10.1002/tcr.202400100","url":null,"abstract":"<p>In this account, we will highlight recent progress in the development of multichannel lanthanide-doped (MC−Ln) nanoprobes for highly efficient serodiagnosis and therapy, with a particular focus on our own work. First, we first provide a classification of the types of MC−Ln nanoprobes based on the contained type and number of signals. The merits of different types of nanoprobes and the reason using lanthanides are elucidated. Then, we provide an overview of the current uses of MC−Ln nanoprobes in serodiagnosis and therapy, focusing on the strategic exploration to improve the diagnostic and therapeutic performance from different perspectives. Finally, we present a prospective outlook on the future development and potential issues of next-generation MC−Ln nanoprobes. We hope that this timely account will update our understanding of MC−Ln and similar nanoprobes for bioapplications and provide helpful references for the state-of-the-art tools for serodiagnosis and therapy.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":"24 10","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/tcr.202400100","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Unlike fossil fuels, biomass has oxygen amounts exceeding 10 wt%. Hydrodeoxygenation (HDO) is a crucial step in upgrading biomass to higher heating value liquid fuels. Oxygen removal has many challenges due to the complex chemistry and the high reactivity leading to irreversible catalyst deactivation. In this study, the focus is on the catalytic HDO of aromatic oxygen-containing model compounds in biomass: phenols and cresols. In the current work, literature on catalytic HDO of phenols using molecular hydrogen is reviewed, with a focus on non-nickel-based mono- and bi-metallic catalysts, as nickel-based catalysts were reviewed elsewhere. In addition, the catalytic HDO of m-cresol using molecular hydrogen is examined. This review also addresses the use of hydrogen donors for the HDO of phenols and cresols. The operating conditions, catalysts, products, and yields are summarized to find the catalyst with promising activity and high selectivity toward aromatics. A critical review of the reactions that successfully led to HDO is presented and research gaps related to the HDO of phenols and cresols are highlighted. The conclusions provide potential successful catalyst combinations that can be used for HDO of phenols, cresols, and liquid aromatic hydrocarbons.
{"title":"Catalytic Hydrodeoxygenation of Phenols and Cresols to Gasoline Range Biofuels","authors":"Ahmed A. Mohammed, Dr. Joy H. Tannous","doi":"10.1002/tcr.202400092","DOIUrl":"10.1002/tcr.202400092","url":null,"abstract":"<p>Unlike fossil fuels, biomass has oxygen amounts exceeding 10 wt%. Hydrodeoxygenation (HDO) is a crucial step in upgrading biomass to higher heating value liquid fuels. Oxygen removal has many challenges due to the complex chemistry and the high reactivity leading to irreversible catalyst deactivation. In this study, the focus is on the catalytic HDO of aromatic oxygen-containing model compounds in biomass: phenols and cresols. In the current work, literature on catalytic HDO of phenols using molecular hydrogen is reviewed, with a focus on non-nickel-based mono- and bi-metallic catalysts, as nickel-based catalysts were reviewed elsewhere. In addition, the catalytic HDO of <i>m</i>-cresol using molecular hydrogen is examined. This review also addresses the use of hydrogen donors for the HDO of phenols and cresols. The operating conditions, catalysts, products, and yields are summarized to find the catalyst with promising activity and high selectivity toward aromatics. A critical review of the reactions that successfully led to HDO is presented and research gaps related to the HDO of phenols and cresols are highlighted. The conclusions provide potential successful catalyst combinations that can be used for HDO of phenols, cresols, and liquid aromatic hydrocarbons.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":"24 10","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142131990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
On May 1, 1965, Roald Hoffmann and R. B. Woodward published their second joint communication, Selection Rules for Concerted Cycloaddition Reactions, in the Journal of the American Chemical Society. Herein is presented a historical analysis of Woodward and Hoffmann's determination of the mechanism of cycloadditions. This analysis is based on thorough analyses with Roald Hoffmann of his 1964 and 1965 laboratory notebooks and his archived documents and on numerous in-person, video, and email interviews. This historical research pinpoints several seminal moments in chemistry and in the professional career of Hoffmann. For example, now documented is the fact that Woodward and Hoffmann had no anticipation that their collaboration would continue after the publication of their first 1965 communication on electrocyclizations. Also pinpointed is the moment in Hoffmann's professional and intellectual trajectories that he became a full-fledged, equal collaborator with Woodward and Hoffmann's transition from a “calculator” to an “explainer.”
1965 年 5 月 1 日,罗尔德-霍夫曼(Roald Hoffmann)和 R. B. 伍德沃德(R. B. Woodward)在《美国化学学会杂志》(Journal of the American Chemical Society)上发表了他们的第二篇联合通讯《协同环化反应的选择规则》(Selection Rules for Concerted Cycloaded Reactions)。本文对伍德沃德和霍夫曼确定环加成反应机理的历史进行了分析。该分析基于对罗纳德-霍夫曼(Roald Hoffmann)1964 年和 1965 年的实验笔记和档案文件的深入分析,以及大量的面谈、视频和电子邮件访谈。这项历史研究指出了霍夫曼在化学和职业生涯中的几个重要时刻。例如,伍德沃德和霍夫曼并没有预料到他们的合作会在 1965 年发表第一篇关于电环化的文章后继续下去,现在这一事实已被记录在案。此外,霍夫曼在其职业和思想轨迹中成为与伍德沃德平等的正式合作者的时刻,以及霍夫曼从 "计算者 "到 "解释者 "的转变,也被准确地记录下来。
{"title":"Woodward-Hoffmann or Hoffmann-Woodward? Cycloadditions and the Transformation of Roald Hoffmann from a “Calculator” to an “Explainer”**","authors":"Jeffrey I. Seeman","doi":"10.1002/tcr.202300181","DOIUrl":"10.1002/tcr.202300181","url":null,"abstract":"<p>On May 1, 1965, Roald Hoffmann and R. B. Woodward published their second joint communication, <i>Selection Rules for Concerted Cycloaddition Reactions</i>, in the <i>Journal of the American Chemical Society</i>. Herein is presented a historical analysis of Woodward and Hoffmann's determination of the mechanism of cycloadditions. This analysis is based on thorough analyses with Roald Hoffmann of his 1964 and 1965 laboratory notebooks and his archived documents and on numerous in-person, video, and email interviews. This historical research pinpoints several seminal moments in chemistry and in the professional career of Hoffmann. For example, now documented is the fact that Woodward and Hoffmann had no anticipation that their collaboration would continue after the publication of their first 1965 communication on electrocyclizations. Also pinpointed is the moment in Hoffmann's professional and intellectual trajectories that he became a full-fledged, equal collaborator with Woodward and Hoffmann's transition from a “calculator” to an “explainer.”</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":"24 8","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/tcr.202300181","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cover Picture: The cover image shows the recommendation of nitrogen circulating based on the development of a catalytic technology to recycle harmful nitrogen oxides (NOx), that should be purified to N2 before releasing to the atmosphere but artificially supplied through high-temperature combustion, as nitrogen compounds like valuable ammonia (NH3), possibly contributing to the sustainability with saving green land and blue sky in future. More details can be found in article number e2024000094 by Tatsuo Kimura (DOl: 10.1002/tcr.202400094.