Mahmood Hassan Akhtar, Muhammad Azhar Hayat Nawaz, Manzar Abbas, Ning Liu, Wenzhao Han, Yan Lv, Cong Yu
pH has been considered one of the paramount factors in bodily functions because most cellular tasks exclusively rely on precise pH values. In this context, the current techniques for pH sensing provide us with the futuristic insight to further design therapeutic and diagnostic tools. Thus, pH-sensing (electrochemically and optically) is rapidly evolving toward exciting new applications and expanding researchers’ interests in many chemical contexts, especially in biomedical applications. The adaptation of cutting-edge technology is subsequently producing the modest form of these biosensors as wearable devices, which are providing us the opportunity to target the real-time collection of vital parameters, including pH for improved healthcare systems. The motif of this review is to provide insight into trending tech-based systems employed in real-time or in-vivo pH-responsive monitoring. Herein, we briefly go through the pH regulation in the human body to help the beginners and scientific community with quick background knowledge, recent advances in the field, and pH detection in real-time biological applications. In the end, we summarize our review by providing an outlook; challenges that need to be addressed, and prospective integration of various pH in vivo platforms with modern electronics that can open new avenues of cutting-edge techniques for disease diagnostics and prevention.
{"title":"Advances in pH Sensing: From Traditional Approaches to Next-Generation Sensors in Biological Contexts","authors":"Mahmood Hassan Akhtar, Muhammad Azhar Hayat Nawaz, Manzar Abbas, Ning Liu, Wenzhao Han, Yan Lv, Cong Yu","doi":"10.1002/tcr.202300369","DOIUrl":"10.1002/tcr.202300369","url":null,"abstract":"<p>pH has been considered one of the paramount factors in bodily functions because most cellular tasks exclusively rely on precise pH values. In this context, the current techniques for pH sensing provide us with the futuristic insight to further design therapeutic and diagnostic tools. Thus, pH-sensing (electrochemically and optically) is rapidly evolving toward exciting new applications and expanding researchers’ interests in many chemical contexts, especially in biomedical applications. The adaptation of cutting-edge technology is subsequently producing the modest form of these biosensors as wearable devices, which are providing us the opportunity to target the real-time collection of vital parameters, including pH for improved healthcare systems. The motif of this review is to provide insight into trending tech-based systems employed in real-time or in-vivo pH-responsive monitoring. Herein, we briefly go through the pH regulation in the human body to help the beginners and scientific community with quick background knowledge, recent advances in the field, and pH detection in real-time biological applications. In the end, we summarize our review by providing an outlook; challenges that need to be addressed, and prospective integration of various pH in vivo platforms with modern electronics that can open new avenues of cutting-edge techniques for disease diagnostics and prevention.</p>","PeriodicalId":10046,"journal":{"name":"Chemical record","volume":null,"pages":null},"PeriodicalIF":7.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141491100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The cover picture shows the progress in the skeletal editing of the isatin scaffold in the last decade (2013-2023). A series of ring-expansion reactions for the construction of high-value heterocycles (quinolines, quinolones, polycyclic quinazolines, medium-sized compounds), as well as a variety of ring-opening strategies for the generation of the 2-(azoly)anilines by cleavage of the C−C bond and the C−N bond are revealed. More details can be found in article number e202400024 by Tiantian Zhang and Huangdi Feng (DOl: 10.1002/tcr.202400024.