Environmental Chemistry and Ecotoxicology最新文献

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IF 8.2 Q1 ENVIRONMENTAL SCIENCES

Environmental Chemistry and Ecotoxicology

Pub Date : 2026-01-01

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IF 8.2 Q1 ENVIRONMENTAL SCIENCES

Environmental Chemistry and Ecotoxicology

Pub Date : 2026-01-01

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IF 8.2 Q1 ENVIRONMENTAL SCIENCES

Environmental Chemistry and Ecotoxicology

Pub Date : 2026-01-01

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IF 8.2 Q1 ENVIRONMENTAL SCIENCES

Environmental Chemistry and Ecotoxicology

Pub Date : 2026-01-01

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IF 8.2 Q1 ENVIRONMENTAL SCIENCES

Environmental Chemistry and Ecotoxicology

Pub Date : 2026-01-01

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IF 8.2 Q1 ENVIRONMENTAL SCIENCES

Environmental Chemistry and Ecotoxicology

Pub Date : 2026-01-01

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IF 8.2 Q1 ENVIRONMENTAL SCIENCES

Environmental Chemistry and Ecotoxicology

Pub Date : 2026-01-01

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Insight into catalytic performance of chlorobenzene over phosphate-modified MnCeOx catalysts and suppression mechanism of polychlorinated byproducts 氯苯在磷酸盐改性MnCeOx催化剂上的催化性能及多氯副产物抑制机理研究

IF 8.2 Q1 ENVIRONMENTAL SCIENCES

Environmental Chemistry and Ecotoxicology

Pub Date : 2026-01-01 DOI: 10.1016/j.enceco.2025.12.020

Runtong Dong , Yunfeng Ma , Yi Liu , Fanxiang Meng , Jiabao Lv , Angjian Wu , Zhongkang Han , Yujue Yang , Bingcheng Lin , Rong Jin , Minghui Zheng , Guorui Liu

Efficient catalytic oxidation of chlorinated volatile organic compounds (CVOCs) with minimal polychlorinated byproducts remains challenging, and the positive effect of water vapor could facilitate it. Based on MnCeOx catalyst, the formation characteristics of polychlorinated benzenes, highly toxic polychlorinated byproducts (PCDD/Fs, PCBs, and PCNs), and PAHs during catalytic oxidation of chlorobenzene (CBCO) were systemically revealed. A phosphate-modified strategy (trimethyl phosphate, CePO₄, and H₃PO₄) was developed for promoting chlorine desorption and desirable inhibition on the polychlorinated byproducts. The trimethyl phosphate TMP-modified catalyst demonstrated highest CB conversion (T₉₀ = 205 °C), stability, and water resistance. A series of experiments involving D₂O-TPD-MS, radical trapping, and DFT calculation provided complete insights into promotion effect of phosphate-modification strategy on the formation of Brønsted acid sites and the hydrolysis effect on H₂O molecule. H₂O performed an essential proton-rich environment and highly reactive water-source oxygen species (·OH), thereby improving dechlorination and deep oxidation properties. The generation pathways of polychlorinated byproducts mainly include reaction steps such as free radical coupling, dechlorination, and condensation. TMP-modified MnCeOx catalyst exhibited the strongest suppression effect on the formation of chlorinated and non-chlorinated byproducts, and their concentrations were decreased by 87.7 % (Polychlorinated benzenes), 82.2 %(PCDD/Fs), 8.5 %(PCBs), and 92.0 %(PAHs), respectively. This work demonstrates a valuable phosphate-modified strategy to suppress the generation of polychlorinated byproducts during CVOCs elimination process and improved the application potential of Mn-based catalysts under practical application conditions (containing water vapor).

有效的催化氧化氯化挥发性有机化合物（CVOCs）并减少多氯副产物仍然是一个挑战，而水蒸气的积极作用可以促进它。基于MnCeOx催化剂，系统揭示了氯苯（CBCO）催化氧化过程中多氯联苯、高毒性多氯联苯副产物（PCDD/Fs、PCBs和PCNs）和多环芳烃的生成特征。采用磷酸三甲基磷酸、CePO4和H3PO4三种磷酸盐改性策略促进了氯的脱附，并对多氯副产物有良好的抑制作用。三甲基磷酸tmp改性催化剂表现出最高的CB转化率（T90 = 205℃）、稳定性和耐水性。通过D2O-TPD-MS、自由基捕获和DFT计算等一系列实验，全面了解了磷酸盐修饰策略对Brønsted酸位形成的促进作用以及对H2O分子的水解作用。H2O是必需的富质子环境和高活性的水源氧（·OH），从而改善了脱氯和深度氧化性能。多氯副产物的生成途径主要包括自由基偶联、脱氯、缩合等反应步骤。tmp修饰的MnCeOx催化剂对氯化副产物和非氯化副产物的生成抑制作用最强，其浓度分别降低87.7%（多氯苯）、82.2% （PCDD/Fs）、8.5% （PCBs）和92.0% （PAHs）。本研究展示了一种有价值的磷酸盐改性策略，可以抑制CVOCs消除过程中多氯副产物的产生，并提高了锰基催化剂在实际应用条件下（含水蒸气）的应用潜力。

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引用次数: 0

The differential cardiotoxicity effects and molecular mechanisms induced by two emerging organophosphorus flame retardants (EHDPP and DPHP) with similar parent structures in zebrafish 两种新型亲本结构相似的有机磷阻燃剂EHDPP和DPHP对斑马鱼的不同心脏毒性作用及其分子机制

IF 8.2 Q1 ENVIRONMENTAL SCIENCES

Environmental Chemistry and Ecotoxicology

Pub Date : 2026-01-01 DOI: 10.1016/j.enceco.2025.12.017

Miaocui Xi, Xue Bai, Lu Fang, Xuedong Wang, Jin Yan, Qiuhui Qian, Zejun Wang, Huili Wang

Herein, we systematically compared the cardiotoxicity effects of two structurally similar organophosphate flame retardants (OPFRs; EHDPP and its major metabolite DPHP) using zebrafishi as a model organism. Predictive toxicity data from two aquatic species, together with empirical LC₅₀ values obtained in zebrafish larvae, consistently demonstrated that 2-ethylhexyl diphenyl phosphate (EHDPP) is substantially more toxic than diphenyl phosphate (DPHP). At LC₅₀-scaled concentrations, both contaminants induced the reduced heart rate, pericardial edema, and cardiac malformations, in concomitant with enhanced activities of creatine kinase (CK) and lactate dehydrogenase (LDH) and downregulated cardiac transcription factors (gata4 and Nkx2.5) and upregulated structural gene cmlc2. Even at low concentrations, EHDPP triggered apoptosis and elevated reactive oxygen species (ROS) levels in cardiac and pericardial tisues, along with prominent lipid accumulation in the heart, vasculature, and intersegmental arteries. It activated multiple pathways including MAPK, calcium signaling, and excitation-contraction coupling, while DPHP primarily affected cardiac function via calcium pump regulation and neuro-signaling pathways. Disease ontology (DO) enrichment analysis revealed that both EHDPP and DPHP associated target genes were most significantly enriched in cardiovascular-related diseases. Pharmacological rescue experiments using pathway-specific agents (Y-27632 and isoproterenol) further validated the functional roles of key signaling pathways in mediating the observed cardiotoxicity. Albeit differing in only one alkyl chain, EHDPP and DPHP displayed significantly differential cardiotoxicity and molecular mechanisms in zebrafish. These observations are conducive to illustrating OPFRs' structure-activity relationship and their health risk.

本文以斑马鱼为模型生物，系统比较了两种结构相似的有机磷阻燃剂（OPFRs、EHDPP及其主要代谢物DPHP）的心脏毒性作用。来自两种水生物种的预测毒性数据，以及在斑马鱼幼虫中获得的经验LC₅0值，一致表明2-乙基己基磷酸二苯酯（EHDPP）的毒性比磷酸二苯酯（DPHP）大得多。在LC₅0标度浓度下，两种污染物均诱导心率降低、心包水肿和心脏畸形，同时肌酸激酶（CK）和乳酸脱氢酶（LDH）活性增强，心脏转录因子（gata4和Nkx2.5）下调，结构基因cmlc2上调。即使在低浓度下，EHDPP也会引发心脏和心包组织的细胞凋亡和活性氧（ROS）水平升高，并在心脏、脉管系统和节段间动脉中产生显著的脂质积累。它激活了包括MAPK、钙信号和兴奋-收缩耦合在内的多种通路，而DPHP主要通过钙泵调节和神经信号通路影响心功能。疾病本体（DO）富集分析显示，EHDPP和DPHP相关靶基因在心血管相关疾病中富集最为显著。利用途径特异性药物（Y-27632和异丙肾上腺素）进行的药理学救援实验进一步验证了关键信号通路在介导所观察到的心脏毒性中的功能作用。尽管EHDPP和DPHP仅在一个烷基链上存在差异，但在斑马鱼中表现出明显不同的心脏毒性和分子机制。这些结果有助于阐明OPFRs的构效关系及其健康风险。

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Environmental endocrine disrupting chemicals in urine and follicular fluid: Association with steroid hormones and risk of polycystic ovarian syndrome 尿和卵泡液中环境内分泌干扰物：与类固醇激素和多囊卵巢综合征风险的关系

IF 8.2 Q1 ENVIRONMENTAL SCIENCES

Environmental Chemistry and Ecotoxicology

Pub Date : 2026-01-01 DOI: 10.1016/j.enceco.2026.01.017

Yarui Liu , Nan Xiao , Yongcheng Li , Yiming Yao , Haining Luo

Organophosphate esters (OPEs), bisphenols, benzophenones, and parabens are acknowledged as endocrine disrupting chemicals (EDCs) and used as flame retardants, plasticizers, and personal care products, but their associations with steroid hormone levels in females diagnosed of polycystic ovarian syndrome (PCOS) remain unclear. In this study, urinary and follicular fluid (FF) concentrations of 9 metabolites of OPEs (mOPEs), 7 bisphenols, 3 benzophenones, and 4 parabens were investigated in childbearing-age females with and without PCOS in China (n = 72). Bis(2-butoxyethyl) 2-hydroxyethyl phosphate (BBOEHEP) had higher FF concentrations in females with PCOS than without PCOS (4.22 and 0.26 ng/mL, p < 0.01). FF EDCs were positively associated with cortisol (p < 0.01). The major contribution came from mOPEs. Specifically, BBOEHEP alone accounted for 87.4% of this contribution. FF BBOEHEP, ΣmOPEs, bisphenol A, and Σbisphenols had positive associations with PCOS risk (OR = 2.58, 95% CI: 1.56, 4.25; OR = 4.93, 95% CI: 2.10, 11.6; OR = 14.1, 95% CI: 3.84, 51.6; OR = 15.0, 95% CI: 3.98, 56.7; p < 0.01). This study suggested FF is a better biomonitoring target for reproductive effects in ovary. The association between EDCs and steroid hormones is also worth further study for understanding their crucial impacts in PCOS females.

有机磷酸酯（OPEs）、双酚类、二苯甲酮和对羟基苯甲酸酯被认为是内分泌干扰化学物质（EDCs），并被用作阻燃剂、增塑剂和个人护理产品，但它们与诊断为多囊卵巢综合征（PCOS）的女性体内类固醇激素水平的关系尚不清楚。本研究对中国育龄女性（72例）的尿液和卵泡液（FF）中9种OPEs代谢物（mOPEs）、7种双酚类、3种二苯甲酮类和4种对羟基苯甲酸酯类的浓度进行了研究。双（2-丁氧乙基）2-羟乙基磷酸酯（BBOEHEP）在PCOS女性体内的FF浓度高于未患PCOS的女性（4.22和0.26 ng/mL, p < 0.01）。FF EDCs与皮质醇呈正相关（p < 0.01）。主要的贡献来自mope。具体而言，仅BBOEHEP就占了这一贡献的87.4%。FF BBOEHEP、ΣmOPEs、双酚A和Σbisphenols与PCOS风险呈正相关（OR = 2.58, 95% CI: 1.56、4.25;OR = 4.93, 95% CI: 2.10、11.6;OR = 14.1, 95% CI: 3.84、51.6;OR = 15.0, 95% CI: 3.98、56.7;p < 0.01）。本研究提示FF是卵巢生殖效应较好的生物监测靶点。EDCs与类固醇激素之间的关系也值得进一步研究，以了解它们在PCOS女性中的重要作用。

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