Nano TransMed最新文献

英文中文

Nano TransMed

Pub Date : 2025-01-01

引用次数: 0

Nano TransMed

Pub Date : 2025-01-01

引用次数: 0

Nano TransMed

Pub Date : 2025-01-01

引用次数: 0

Nano TransMed

Pub Date : 2025-01-01

引用次数: 0

Nano TransMed

Pub Date : 2025-01-01

引用次数: 0

Nanocarriers in skin cancer treatment: Emerging drug delivery approaches and innovations 纳米载体在皮肤癌治疗：新兴的药物输送方法和创新

Nano TransMed

Pub Date : 2024-12-17 DOI: 10.1016/j.ntm.2024.100068

Laxmi A. Jadhav, Satish K. Mandlik

Background

Skin cancer is a growing global health issue, with rising incidence rates, particularly among Caucasian populations. It is the most common malignancy, contributing significantly to mortality and decreased quality of life worldwide. While surgical interventions remain the primary treatment, there is a pressing need for innovative strategies to reduce the morbidity and mortality associated with the disease. As the burden of skin cancer continues to grow, the medical community is increasingly exploring novel therapeutic approaches to improve patient outcomes.

Main body

Nanotechnology has introduced new possibilities for treating skin cancer, offering advantages in targeted drug delivery, advanced imaging, and diagnostics. Nanomaterials are especially useful in dermatology, as they enhance the penetration and retention of therapeutic agents while minimizing side effects. Various nanomaterials have been studied for their potential in treating skin disorders, including cancer. This review examines the role of nanotechnology in skin cancer treatment, focusing on the development and design of nanocarriers for the precise delivery of drugs. We also discuss the advantages of nanotechnology over traditional treatments, such as improved bioavailability and targeted action. Additionally, we explore clinical trials, patents and FDA approved products related to nanocarrier-based treatments for cancer and skin cancer, highlighting advancements in the field.

Conclusion

Nanotechnology holds significant promise in revolutionizing skin cancer treatment. As research progresses, it is expected that more effective, personalized therapies will emerge, ultimately improving patient outcomes. Integrating nanotechnology into clinical practice could elevate the standard of care, offering new hope in managing skin cancer.

皮肤癌是一个日益严重的全球健康问题，发病率不断上升，尤其是在高加索人群中。它是最常见的恶性肿瘤，在世界范围内显著导致死亡率和生活质量下降。虽然手术干预仍然是主要的治疗方法，但迫切需要创新的策略来降低与该疾病相关的发病率和死亡率。随着皮肤癌的负担持续增长，医学界越来越多地探索新的治疗方法来改善患者的预后。纳米技术为治疗皮肤癌带来了新的可能性，在靶向药物输送、先进成像和诊断方面提供了优势。纳米材料在皮肤病学中特别有用，因为它们增强了治疗剂的渗透和保留，同时最小化了副作用。人们研究了各种纳米材料在治疗包括癌症在内的皮肤疾病方面的潜力。本文综述了纳米技术在皮肤癌治疗中的作用，重点介绍了用于精确递送药物的纳米载体的开发和设计。我们还讨论了纳米技术相对于传统治疗的优势，例如提高生物利用度和靶向作用。此外，我们还探讨了与基于纳米载体的癌症和皮肤癌治疗相关的临床试验、专利和FDA批准的产品，重点介绍了该领域的进展。结论纳米技术在皮肤癌治疗中具有革命性的前景。随着研究的进展，预计将出现更有效、更个性化的治疗方法，最终改善患者的预后。将纳米技术整合到临床实践中可以提高护理标准，为治疗皮肤癌提供新的希望。

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引用次数: 0

Nano delivery systems in stem cell therapy: Transforming regenerative medicine and overcoming clinical challenges 纳米输送系统在干细胞治疗：转化再生医学和克服临床挑战

Nano TransMed

Pub Date : 2024-12-15 DOI: 10.1016/j.ntm.2024.100069

Aswini Rajendran, Rithi Angelin Rajan, Saranya Balasubramaniyam, Karthikeyan Elumalai

Stem cell therapy has emerged as a promising approach in regenerative medicine, offering potential treatments for various degenerative diseases and injuries. However, the clinical application of stem cell therapy faces challenges such as low cell viability, inefficient delivery to target sites, and immune rejection. Nanodelivery systems (NDS) have the potential to address these limitations and enhance the efficacy of stem cell-based treatments. This review looks at how NDS can help stem cell therapy work well by creating a safe environment, allowing targeted delivery, and making it easier to control the release of therapeutic factors. The article discusses various types of NDS, including liposomes, polymeric nanoparticles, mesoporous silica nanoparticles, gold nanoparticles, and magnetic nanoparticles, highlighting their unique properties and advantages in stem cell therapy applications. Furthermore, the review examines the potential of NDS in specific areas of regenerative medicine, such as cardiovascular regeneration, neurodegenerative diseases, musculoskeletal tissue repair, and wound healing. The article also addresses the challenges and limitations associated with NDS, such as biocompatibility, toxicity, manufacturing scalability, and regulatory hurdles. Finally, the article explores the future trajectory of nanotechnology in stem cell therapy, discussing the utilization of intelligent nanoparticles, precision genetic modifications, and the benefits of personalized nanomedicine.

干细胞治疗已经成为再生医学中一个很有前途的方法，为各种退行性疾病和损伤提供了潜在的治疗方法。然而，干细胞治疗的临床应用面临着诸如细胞活力低、靶向部位递送效率低和免疫排斥等挑战。纳米递送系统（NDS）有潜力解决这些限制并提高干细胞治疗的疗效。这篇综述着眼于NDS如何通过创造一个安全的环境，允许靶向递送，并使其更容易控制治疗因子的释放来帮助干细胞治疗更好地工作。本文讨论了NDS的各种类型，包括脂质体、聚合物纳米颗粒、介孔二氧化硅纳米颗粒、金纳米颗粒和磁性纳米颗粒，重点介绍了它们在干细胞治疗中的独特性质和优势。此外，本文还探讨了NDS在再生医学特定领域的潜力，如心血管再生、神经退行性疾病、肌肉骨骼组织修复和伤口愈合。本文还讨论了与NDS相关的挑战和限制，例如生物相容性、毒性、制造可扩展性和监管障碍。最后，本文探讨了纳米技术在干细胞治疗中的未来发展轨迹，讨论了智能纳米粒子的应用，精确的基因修饰，以及个性化纳米医学的好处。

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引用次数: 0

Abutilon indicum-mediated green synthesis of NiO and ZnO nanoparticles: Spectral profiling and anticancer potential against human cervical cancer for public health progression Abutilon铟介导的NiO和ZnO纳米颗粒的绿色合成：光谱分析和对人类宫颈癌的抗癌潜力，以促进公共卫生进展

Nano TransMed

Pub Date : 2024-12-01 DOI: 10.1016/j.ntm.2024.100049

Vinotha Mani , Keerthana Shrri Gopinath , Nithya Varadharaju , Dapkupar Wankhar , Arjunan Annavi

Background

Integrating nanomedicines for targeted cancer treatment and pursuing medicinally valuable components from nature are crucial for sustainable, potent alternatives to synthetic drugs in combating fatal diseases like cancer. Hence, a green synthesis of nickel oxide (NiO NPs) and zinc oxide nanoparticles (ZnO NPs) has been carried out by using the leaf extract of medicinally important plant Abutilonindicum. This sustainable approach to medical developments not only reduces the environmental effect of standard synthesis methods and offers new options for novel cancer therapeutics, but it also advances public health by using natural resources in a sustainable manner.

Methods

The synthesized nanoparticles were characterized by employing spectro-analytical techniques like UV–vis, FT-IR, SEM and powder XRD. Synthesized nanparticles were evaluated in the human cervical cancer cells (HeLa).

Results

Ni-O stretching vibrations were observed at 402 cm⁻¹, whereas that of Zn-O stretching was observed at 409 cm⁻¹in the FT-IR spectrum, confirming the formation of nanoparticles. The XRD pattern revealed the crystallite size range of 1.35–2.84 nm for NiO NPs and 7.71–56.80 nm for ZnO NPs. The morphology of the nanoparticles, as indicated by the SEM images, was rod-like for NiO NPs and rock-shaped for ZnO NPs. Further, the cancer cell growth inhibition activity of the nanoparticles was examined by MTT assay against human cervical cancer cells (HeLa) proliferation and compared with cisplatin. MTT assay elucidated the significant anticancer efficacy of the synthesized nanoparticles, showcasing low IC₅₀ values of 29±0.5 µg/ml for NiO NPs and 32±0.7 µg/ml for ZnO NPs. Furthermore, the anticancer activity of the NiO NPs was investigated using the Trypan blue dye exclusion technique, emphasizing the pronounced cytotoxic impact of NiO NPs on cancer cell viability. The outcomes underscore the notable anticancer properties of plant extract mediated metal nanoparticles as promising contenders for advancing cancer treatment modalities.

将纳米药物整合到靶向癌症治疗中，并从自然界中寻找有药用价值的成分，对于在对抗癌症等致命疾病中替代合成药物的可持续、有效的替代品至关重要。因此，以药用植物Abutilonindicum的叶提取物为原料，进行了氧化镍（NiO NPs）和氧化锌纳米颗粒（ZnO NPs）的绿色合成。这种可持续的医疗发展方法不仅减少了标准合成方法对环境的影响，并为新型癌症治疗提供了新的选择，而且还通过可持续地利用自然资源促进了公共卫生。方法采用UV-vis、FT-IR、SEM和粉末XRD等光谱分析技术对合成的纳米颗粒进行表征。合成纳米粒子在人宫颈癌细胞（HeLa）中的作用进行了评价。结果在402 cm−1处观察到ni - o的拉伸振动，而在409 cm−1处观察到Zn-O的拉伸振动，证实了纳米颗粒的形成。XRD图谱显示，NiO NPs的晶粒尺寸范围为1.35 ~ 2.84 nm， ZnO NPs的晶粒尺寸范围为7.71 ~ 56.80 nm。SEM图像显示，NiO纳米颗粒呈棒状，ZnO纳米颗粒呈岩石状。采用MTT法检测纳米颗粒对人宫颈癌细胞（HeLa）增殖的抑制作用，并与顺铂进行比较。MTT实验表明，合成的纳米颗粒具有显著的抗癌效果，NiO NPs的IC50值为29±0.5 µg/ml， ZnO NPs的IC50值为32±0.7 µg/ml。此外，利用台锥蓝染料排斥技术研究了NiO NPs的抗癌活性，强调了NiO NPs对癌细胞活力的显著细胞毒性作用。这些结果强调了植物提取物介导的金属纳米颗粒具有显著的抗癌特性，是推进癌症治疗方式的有希望的竞争者。

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引用次数: 0

Nanoindentation: Introduction and applications of a non-destructive analysis 纳米压痕：无损分析的介绍和应用

Nano TransMed

Pub Date : 2024-12-01 DOI: 10.1016/j.ntm.2024.100057

Zaid H. Mahmoud , H.N.K. AL-Salman , Ehsan Kianfar

Nanoindentation test is known as a powerful method for non-destructive characterization and analysis of mechanical properties of nanoscale materials. In this method, the indenting tip penetrates the surface of the sample by applying a force of several millinewtons to the extent of several nanometers, and the resulting force-displacement curve is used as the output of the test to calculate the mechanical characteristics of the sample, including hardness and elastic modulus, as well as to identify various mechanical phenomena such as Creep, strain hardening, surface cracking, phase transformations, creep and fracture toughness of the material are used. In this article, the Nanoindentation method is briefly introduced and its principles and basics are discussed. The application of this method is valid for analyzing the mechanical properties of a wide range of materials. The purpose of this article is to familiarize researchers and experts in engineering fields with the nanoindentation method as a non-destructive analysis and its effective use in their respective fields of application.

纳米压痕测试是一种无损表征和分析纳米材料力学性能的有力方法。在该方法中，压痕尖端通过施加几毫牛顿到几纳米的力穿透试样表面，并将得到的力-位移曲线作为试验的输出，计算试样的硬度和弹性模量等力学特性，并识别蠕变、应变硬化、表面开裂、相变等各种力学现象。使用材料的蠕变和断裂韧性。本文简要介绍了纳米压痕法，并对其原理和基本原理进行了讨论。该方法适用于分析各种材料的力学性能。本文的目的是使工程领域的研究人员和专家熟悉纳米压痕法作为一种无损分析方法及其在各自应用领域的有效应用。

引用次数: 0

Nanotechnology-based advancements for effective delivery of phytoconstituents for Ocular diseases 基于纳米技术的眼部疾病有效递送植物成分的进展

Nano TransMed

Pub Date : 2024-12-01 DOI: 10.1016/j.ntm.2024.100056

Venkateshwaran Krishnaswami , Dhilin Pathayappurakkal Mohanan , S.A. Jacob Raja , Balakrishnan Natarajan , Shankarananth Velusamy

Phytomedicines has been globally utilized in ancient times. Phytoconstituents such as flavonoids, glycosides, peptides, carbohydrates, lipids, alkaloids, tannins, and terpenoids are holding medicinal properties. Previous reports have documented the various therapeutic activities of plant extracts/isolated fractions/pure phytoconstituents especially at in vitro levels. But the relevance towards the in vivo level and upmost towards the clinical trials for these phytomedicines was facing numerous challenges in the current scenario. The challenges associated with phytomedicines are standardization issues, ineffective against serious ailments, poor reproducibility of biological activities and interferences with associated phytoconstituents. But recently nanoscale based phytomedicine is paving more interest towards the scientific community for ocular delivery. In order to overcome these issues the nanoscale base phytomedicines delivery systems are recently developed by researchers. Nanoscale delivery systems of various phytoconstituents may potentiate the therapeutic effect, improves the bioavailability, reduces adverse effects and decreases the effective dose. The scope of this paper will focus towards the nanotechnology based phytomedicine delivery systems for various therapeutic applications in eye. The various phytomedicine loaded nanoscale delivery systems such as nanoparticles, nanomicelles, nanodispersions, lipid based nanoparticles for various ocular diseases has been reviewed. Special focus has been emphasized towards the carriers utilized for those delivery systems. Additionally, the future perspectives relating to development of novel phytomedicine based nano formulations has been discussed.

植物药在古代就被全球广泛使用。植物成分如黄酮类、糖苷类、多肽、碳水化合物、脂类、生物碱、单宁和萜类具有药用特性。以前的报告已经记录了植物提取物/分离组分/纯植物成分的各种治疗活性，特别是在体外水平。但在目前的情况下，这些植物药物与体内水平的相关性，尤其是与临床试验的相关性面临着许多挑战。与植物药物相关的挑战是标准化问题，对严重疾病无效，生物活性的可重复性差以及对相关植物成分的干扰。但是最近，基于纳米尺度的植物医学正引起科学界对眼部输送的更多兴趣。为了克服这些问题，研究人员最近开发了纳米尺度的基础植物药输送系统。各种植物成分的纳米级递送系统可以增强治疗效果，提高生物利用度，减少不良反应和降低有效剂量。本文将重点讨论基于纳米技术的植物药物输送系统在眼科的各种治疗应用。综述了各种植物药负载纳米递送系统，如纳米颗粒、纳米胶束、纳米分散体、脂质纳米颗粒等，用于各种眼病的治疗。特别强调了用于这些运送系统的运载工具。此外，还讨论了新型植物药纳米制剂的发展前景。

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