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Nanostructured materials for breast cancer therapeutics enhancing drug delivery through nanofibers, nano-mesh, and nanoflowers 用于乳腺癌治疗的纳米结构材料通过纳米纤维、纳米网和纳米花增强药物传递
Pub Date : 2025-01-01 DOI: 10.1016/j.nxnano.2025.100159
Navya Aggarwal, Shreya Gupta, Shinjini Sen, Tanmay J. Urs, Banashree Bondhopadhyay
Breast cancer drug delivery systems rely heavily on conventional routes of administration through adjuvant formulations. These systems have been under development for decades to deduce safer, bioavailable, specific, selective and efficacious modalities. Nanotechnology based drug delivery systems proposed to solve these issues, have led to a boom in nanoparticle based, liposomal, nanovesicles, nanocapsules, and similar provisions. The improvement of the existing available systems inspired biodegradable nanostructures such as nanofibers, nanomesh and nanoflowers. These structures provide better opportunities to improve targetability, bioavailability, better safety profiles. The platforms additionally facilitate controlled release of the loaded drugs. This minireview explores nanofibers, nanomesh and nanoflowers in breast cancer treatment as emerging nanostructures for delivery of chemotherapeutics. Nanofibers emulate the natural extracellular matrix which can be modified for biodegradability and tumor identification. Nanomesh provide large drug-antigen loading platform with interwoven strands.On the other hand, nanoflowers can be conveniently modulated to control the release of the drug. These nanostructures offer innovative solutions to the typical drawbacks of drug absorption, selectivity and delivery on tumor sight. In this minireview, we aim to comprehensively present how these nanostructures are created, address their mechanism of action and how they are developing the landscape of breast cancer drug delivery systems.The study prioritizes these nanostructures over their conventional counterparts due to their visible benefits while also addressing their limitations which should be further researched upon, for breast cancer therapeutics.
乳腺癌药物输送系统严重依赖传统的辅助制剂给药途径。这些系统已经开发了几十年,以推断出更安全、生物可利用、特异性、选择性和有效的模式。纳米技术为解决这些问题而提出的基于纳米技术的药物传递系统,导致了基于纳米颗粒、脂质体、纳米囊泡、纳米胶囊和类似产品的蓬勃发展。现有系统的改进激发了可生物降解的纳米结构,如纳米纤维、纳米网和纳米花。这些结构提供了更好的机会来提高靶向性、生物利用度和更好的安全性。该平台还有助于负载药物的控释。这篇微型综述探讨了纳米纤维、纳米网和纳米花在乳腺癌治疗中的应用,它们是用于化疗药物输送的新兴纳米结构。纳米纤维模拟天然细胞外基质,可以进行生物降解和肿瘤鉴定。纳米网提供了一个大的药物抗原装载平台。另一方面,可以方便地调节纳米花来控制药物的释放。这些纳米结构提供了创新的解决方案,以克服典型的药物吸收、选择性和肿瘤视线上的递送缺陷。在这篇微型综述中,我们旨在全面介绍这些纳米结构是如何产生的,阐述它们的作用机制以及它们是如何发展乳腺癌药物输送系统的。这项研究优先考虑这些纳米结构,因为它们具有明显的好处,同时也解决了它们在乳腺癌治疗方面的局限性,这些局限性需要进一步研究。
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引用次数: 0
Zinc oxide-nanoparticle impregnated poultry droppings activated carbon for model oil desulfurization: Experimental investigation and regression modelling with uncertainty quantification 氧化锌-纳米颗粒浸渍家禽粪便活性炭模型油脱硫:实验研究和不确定定量回归模型
Pub Date : 2025-01-01 DOI: 10.1016/j.nxnano.2025.100164
Kazeem K. Salam , Idayat A. Olowonyo , Kehinde A. Babatunde , Monsuru O. Dauda , Dauda O. Araromi , Mujidat O. Aremu , Opeoluwa D. Sole-Adeoye , Temitope O. Adesina
This study presents a novel, eco-friendly approach for adsorptive desulfurization, utilizing Poultry Droppings (PD) and Garlic Peel (GP) wastes to develop a high-performance green adsorbent for the removal of Dibenzothiopene (DBT) from Model Oil (MO). PD was thermally and chemically modified to PD-Activated Carbon (PDAC) and PDAC impregnated with Zinc Oxide Nanoparticles (PDAC-ZnO-NPs). The produced adsorbents (PDAC and PDAC-ZnO-NPs) were appropriately characterized. Batch adsorption experiment was designed by Definitive Screening Design (DSD) for parameters: adsorption temperature (25 – 50°C), contact time (10 – 60 min), agitation rate (50 – 250 rpm), and adsorbent dosage (50 – 250 mg). ZnO nanoparticle impregnation increased the surface area from 965 m²/g to 981 m²/g and enhanced the availability of oxygen-containing functional groups, thereby improving DBT affinity. The BET surface area increased from 965 m²/g to 981 m²/g after ZnO-NP impregnation, indicating enhanced adsorption capacity. The equilibrium data for DBT removal were fitted to isotherm, kinetic, and thermodynamic models, with model constants evaluated. The desulfurization process achieved an optimum DBT percentage removal (%DBTR) of 85.47 % with PDAC and 95.12 % with PDAC-ZnO-NPs. The desulfurization equilibrium data fitted the Freundlich isotherm, the Pseudo-Second-Order (PSO) kinetic model and, thermodynamic analysis indicated that DBT removal process was spontaneous and endothermic, with entropy (ΔS) and enthalpy (ΔH) changes of 140.12 J/mol·K and 40.25 kJ/mol for PDAC, and 110.49 J/mol·K and 30.01 kJ/mol for PDAC-ZnO-NPs respectively. The %DBTR decreased by 6.1 % for PDAC-ZnO-NPs after five regeneration cycles, demonstrating its reusability. This study demonstrates the potential of sustainable bio-based adsorbents for efficient adsorptive desulfurization, paving the way for cleaner fuel production and enhanced environmental sustainability.
本研究提出了一种新的、环保的吸附脱硫方法,利用家禽粪便(PD)和大蒜皮(GP)废物开发一种高性能的绿色吸附剂,用于去除模型油(MO)中的二苯并噻吩(DBT)。对PD进行了热化学改性,得到了PD-活性炭(PDAC)和PDAC浸渍氧化锌纳米颗粒(PDAC- zno - nps)。制备的吸附剂(PDAC和PDAC- zno - nps)进行了表征。采用确定性筛选设计(DSD)设计间歇式吸附实验,参数为:吸附温度(25 ~ 50℃)、接触时间(10 ~ 60 min)、搅拌速率(50 ~ 250 rpm)、吸附剂用量(50 ~ 250 mg)。ZnO纳米颗粒浸渍使其比表面积从965 m²/g增加到981 m²/g,并增强了含氧官能团的有效性,从而提高了DBT的亲和力。ZnO-NP浸渍后,BET比表面积由965 m²/g增加到981 m²/g,吸附能力增强。将DBT去除的平衡数据拟合到等温线、动力学和热力学模型中,并计算了模型常数。PDAC和PDAC- zno - nps的最佳DBT去除率分别为85.47 %和95.12 %。脱硫平衡数据符合Freundlich等温线和伪二阶(PSO)动力学模型,热力学分析表明DBT脱除过程是自发的吸热过程,PDAC的熵(ΔS)和焓(ΔH)变化分别为140.12 J/mol·K和40.25 kJ/mol, PDAC- zno - nps的熵(ΔS)和焓(ΔH)变化分别为110.49 J/mol·K和30.01 kJ/mol。经过5次再生循环后,PDAC-ZnO-NPs的DBTR %下降了6.1 %,表明其可重复使用。这项研究证明了可持续生物基吸附剂在高效吸附脱硫方面的潜力,为清洁燃料生产和增强环境可持续性铺平了道路。
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引用次数: 0
Enhancing mechanical and tribological performance of poly(ether-ether-ketone)/hydroxyapatite nanocomposites with flower-like zinc oxide for bone replacement 花状氧化锌增强聚醚-醚酮/羟基磷灰石纳米复合材料的力学和摩擦学性能
Pub Date : 2025-01-01 DOI: 10.1016/j.nxnano.2025.100143
Monica Rufino Senra , Igor Tenório Soares , Vanessa Kapps , Marcia Marie Maru , Maria de Fatima Vieira Marques
Driven by population aging, rising obesity rates, sports injuries, and road traffic accidents, the global orthopedic implant market is projected to reach US$79.5 billion by the end of this decade, highlighting the growing demand for durable and high-performance implant materials. Poly(ether-ether-ketone) (PEEK) has emerged as a promising alternative to traditional metallic implants due to its biocompatibility, excellent tribological properties, and mechanical characteristics similar to human bone. However, its bioinert nature limits osseointegration, affecting long-term implant stability. This study presents the development of PEEK-based nanocomposites reinforced with hydroxyapatite (HA) to promote osseointegration and zinc oxide (ZnO) nanoparticles in spherical (cZnO) and flower-like (fZnO) morphologies to enhance tribological performance. The nanocomposites were evaluated through scratch testing, providing quantitative insights into their mechanical and wear resistance properties. The results demonstrated that fZnO significantly improved scratch resistance, reducing residual scratch depth by 34 % compared to cZnO-reinforced composites. Moreover, while the addition of HA did not compromise the reinforcing effect of fZnO, the cZnO-HA hybrid nanocomposite exhibited a 20 % lower coefficient of friction (COF), which could be problematic for implant stability due to potential loosening. In contrast, the fZnO-HA hybrid nanocomposite demonstrated superior scratch resistance, lower pile-up formation, and improved fixation, making it a particularly promising candidate for load-bearing orthopedic applications such as hip prosthesis stems. These findings confirm that nanoparticle morphology plays a critical role in optimizing mechanical and tribological performance in PEEK-based nanocomposites, paving the way for advanced biomaterials with enhanced wear resistance and durability.
在人口老龄化、肥胖率上升、运动损伤和道路交通事故的推动下,到本十年末,全球骨科植入物市场预计将达到795亿美元,这突出了对耐用和高性能植入材料的需求不断增长。聚醚醚酮(PEEK)由于其生物相容性、优异的摩擦学性能和与人骨相似的机械特性,已成为传统金属植入物的有前途的替代品。然而,其生物惰性限制了骨整合,影响了种植体的长期稳定性。本研究提出了羟基磷灰石(HA)增强peek基纳米复合材料,以促进骨整合和球形(cZnO)和花状(fZnO)形态的氧化锌(ZnO)纳米材料,以提高摩擦学性能。通过划痕测试对纳米复合材料进行了评估,提供了对其机械性能和耐磨性的定量分析。结果表明,与czno增强复合材料相比,fZnO显著提高了材料的抗划伤性能,使残余划伤深度降低了34% %。此外,虽然HA的加入没有影响fZnO的增强作用,但cZnO-HA杂化纳米复合材料的摩擦系数(COF)降低了20% %,这可能会由于潜在的松动而影响植入物的稳定性。相比之下,fZnO-HA混合纳米复合材料表现出优异的耐划伤性,更低的堆积形成,以及改进的固定,使其成为承重骨科应用(如髋关节假体)的特别有前途的候选者。这些发现证实,纳米颗粒形态在优化peek基纳米复合材料的机械和摩擦学性能方面起着至关重要的作用,为具有增强耐磨性和耐久性的先进生物材料铺平了道路。
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引用次数: 0
Impact of bridging the gap between Artificial Intelligence and nanomedicine in healthcare 弥合人工智能和纳米医学在医疗保健领域差距的影响
Pub Date : 2025-01-01 DOI: 10.1016/j.nxnano.2025.100203
Divyam Mishra , Bhavishya Chaturvedi , Vishal Soni , Dhairya Valecha , Megha Goel , Jamilur R. Ansari
Nanotechnology encompasses the engineering and manipulation of materials at the nanoscale (10−9 m), focusing on the development and application of novel structures and concepts. Concurrently, Artificial Intelligence (AI) simulates human cognitive processes, enabling machines to make decisions and solve problems. Within AI, subfields such as Machine Learning and Deep Learning leverage vast datasets to predict outcomes based on historical trends. This research examines the intersection of AI and nanotechnology within the medical sector, with an emphasis on illness localization, diagnosis, and therapeutic interventions. AI's deployment in molecular imaging has proven invaluable for early disease detection and treatment via biosensors. A key aspect of our analysis is the utilization of AI to formulate personalized treatment plans, enhancing the probability of achieving optimal drug-patient synergy. Additionally, we explore the development of AI-powered nanobots, capable of autonomous logical reasoning to target malignant cells for localized cancer therapy. The optimization of AI-driven drug delivery systems using nanoparticles demonstrates significant potential for surpassing the efficacy of existing delivery mechanisms. We will also assess the long-term implications of lipid nanoparticles in drug delivery applications. Machine Learning algorithms are employed to create data-driven adaptive nanomaterials and paradigms, further advancing the field. Furthermore, this study investigates the application of AI in predicting nanomedicine interactions with biological systems, aiming to establish AI-enabled platforms for personalized nanomedicine therapies. In summary, our work highlights the synergistic potential of AI and nanotechnology in catalyzing breakthroughs in medical innovation.
纳米技术包括纳米尺度(10 - 9米)材料的工程和操作,重点是新结构和概念的开发和应用。同时,人工智能(AI)模拟人类的认知过程,使机器能够做出决策和解决问题。在人工智能领域,机器学习和深度学习等子领域利用大量数据集根据历史趋势预测结果。本研究考察了人工智能和纳米技术在医疗领域的交叉,重点是疾病定位、诊断和治疗干预。事实证明,人工智能在分子成像领域的应用对于通过生物传感器进行早期疾病检测和治疗是非常宝贵的。我们分析的一个关键方面是利用人工智能制定个性化治疗计划,提高实现最佳药物-患者协同作用的可能性。此外,我们还探索了人工智能驱动的纳米机器人的发展,这些纳米机器人能够自主逻辑推理,针对恶性细胞进行局部癌症治疗。利用纳米颗粒优化人工智能驱动的药物递送系统显示出超越现有递送机制功效的巨大潜力。我们还将评估脂质纳米颗粒在药物输送应用中的长期影响。机器学习算法被用于创建数据驱动的自适应纳米材料和范例,进一步推进了该领域。此外,本研究还研究了人工智能在预测纳米药物与生物系统相互作用方面的应用,旨在建立个性化纳米药物治疗的人工智能平台。总之,我们的工作突出了人工智能和纳米技术在催化医学创新突破方面的协同潜力。
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引用次数: 0
Advanced approaches in lung cancer therapy–Exploring the unique role of Multiwalled Carbon Nanotubes 肺癌治疗的新方法——探索多壁碳纳米管的独特作用
Pub Date : 2025-01-01 DOI: 10.1016/j.nxnano.2025.100180
Pushpendra Kumar Khangar , Vivek Daniel
<div><h3>Hypothesis</h3><div>This paper hypothesizes that Multiwalled Carbon Nanotubes (MWCNTs) can serve as effective nanocarriers for anticancer drug delivery in lung cancer therapy. Their high surface area, biocompatibility, and adaptable surface chemistry make them promising candidates for enhancing drug delivery efficiency. MWCNTs offer the potential to enable targeted transport of anticancer drugs directly to lung cancer cells, reducing systemic toxicity through controlled and prolonged drug release while also improving drug clearance mechanisms. However, despite these advantages, the study acknowledges significant concerns regarding toxicity, biocompatibility, and long-term safety. Addressing these challenges is crucial for the successful clinical translation of MWCNT-based drug delivery systems.</div></div><div><h3>Experiments (review-based analysis)</h3><div>Although this study does not conduct direct experiments, it reviews existing research and experimental findings on the incorporation of anticancer drugs into Multiwalled Carbon Nanotubes (MWCNTs), which involves efficient loading and release methods that ensure drug stability and retention within the nanocarrier system. These approaches enhance the controlled delivery of therapeutic agents, preventing premature degradation and maximizing efficacy. MWCNTs play a crucial role in drug delivery by improving circulation, enabling controlled release, and minimizing systemic toxicity. Additionally, surface modifications of MWCNTs contribute to better drug delivery efficiency by enhancing solubility and targeting capabilities. However, concerns regarding safety and biocompatibility remain critical. Preclinical studies have been conducted to evaluate the toxicity, biodegradability, and inflammatory response associated with MWCNTs. Surface modifications have been explored as a strategy to mitigate adverse effects, improve cellular compatibility, and enhance the overall feasibility of MWCNT-based drug delivery systems for lung cancer therapy.</div></div><div><h3>Findings</h3><div>MWCNT-based drug delivery demonstrates significant potential in improving lung cancer treatment by enabling targeted drug transport to cancer cells, thereby enhancing therapeutic efficacy. The controlled release of drugs from MWCNTs helps minimize systemic toxicity, ultimately improving patient safety and treatment outcomes. However, several challenges and limitations must be addressed before clinical implementation. Toxicity remains a primary concern, as MWCNTs may trigger inflammatory responses or accumulate in tissues, leading to potential long-term adverse effects. Additionally, the biocompatibility and overall safety of these nanocarriers require further validation through rigorous preclinical testing. Looking ahead, extensive research is essential to develop clinically viable MWCNT-based drug delivery systems. Further advancements in surface modifications and biodegradability enhancements are necessary to reduce
本文假设多壁碳纳米管(MWCNTs)可作为肺癌治疗中有效的抗癌药物递送纳米载体。它们的高表面积,生物相容性和适应性表面化学使它们成为提高药物传递效率的有希望的候选者。MWCNTs有可能实现抗癌药物直接靶向转运到肺癌细胞,通过控制和延长药物释放降低全身毒性,同时改善药物清除机制。然而,尽管有这些优点,该研究承认在毒性、生物相容性和长期安全性方面存在重大问题。解决这些挑战对于基于mwcnts的给药系统的成功临床转化至关重要。实验(基于综述的分析)虽然本研究没有进行直接实验,但它回顾了关于将抗癌药物纳入多壁碳纳米管(MWCNTs)的现有研究和实验结果,其中涉及有效的加载和释放方法,以确保药物在纳米载体系统中的稳定性和保留。这些方法加强了治疗药物的控制递送,防止过早降解并最大限度地提高疗效。MWCNTs通过改善循环、实现控制释放和最小化全身毒性,在药物递送中发挥关键作用。此外,MWCNTs的表面修饰通过增强溶解度和靶向能力,有助于提高药物递送效率。然而,对安全性和生物相容性的担忧仍然至关重要。临床前研究评估了与MWCNTs相关的毒性、生物降解性和炎症反应。表面修饰作为一种减轻不良反应、改善细胞相容性和增强基于mwcnts的肺癌治疗药物传递系统整体可行性的策略已被探索。基于smwcnt的药物递送在改善肺癌治疗方面显示出巨大的潜力,它使靶向药物转运到癌细胞,从而提高治疗效果。MWCNTs药物的可控释放有助于最大限度地减少全身毒性,最终提高患者安全性和治疗效果。然而,在临床实施之前,必须解决一些挑战和限制。毒性仍然是一个主要问题,因为MWCNTs可能引发炎症反应或在组织中积累,导致潜在的长期不良反应。此外,这些纳米载体的生物相容性和整体安全性需要通过严格的临床前测试进一步验证。展望未来,广泛的研究对于开发临床可行的基于mwcnts的给药系统至关重要。为了降低毒性和提高临床安全性,有必要在表面修饰和生物降解性方面取得进一步进展,为MWCNTs在肺癌纳米药物中的成功整合铺平道路。
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引用次数: 0
Chitosan nanoparticles for insulin delivery in type 1 diabetes: Overcoming challenges in bioavailability and long-term control 壳聚糖纳米颗粒用于1型糖尿病胰岛素递送:克服生物利用度和长期控制方面的挑战
Pub Date : 2025-01-01 DOI: 10.1016/j.nxnano.2025.100254
Subhajit Maity
Type 1 diabetes (T1D) cohort requires a lifelong insulin supplement but the traditional insulin delivery systems have severe drawbacks such as unacceptable bioavailability of the drug, frequent regimens, lack of patient adherence. This paper will discuss the use of chitosan nanoparticles (CNPs) as a new form of insulin delivery vehicle, and the potential that this possesses to improve its effectiveness as a form of therapy. CNPs enhance the stability of insulin stabilizing it against enzymatic degradation; they also allow controlled release. On the other hand, their mucoadhesive properties prolong intestinal retention that can improve absorption and reduce dosing frequency, which can improve patient compliance. Again, the CNPs encapsulate insulin through electrostatic interactions that can prevent degradation in the gastrointestinal tract while endorsing sustained glucose regulation. Furthermore, this study specify that CNP-based insulin delivery significantly expands glycemic control and reduces hypoglycemia risks. Despite their advantages, challenges include variability in insulin release, scalability in production, and regulatory hurdles. Future advancements, such as hybrid systems and stimuli-responsive nanoparticles, aim to optimize stability and targeted insulin delivery. The integration of nanomedicine into diabetes management may revolutionize treatment, offering a more effective and patient-friendly approach.
1型糖尿病(T1D)患者需要终生补充胰岛素,但传统的胰岛素输送系统存在严重的缺陷,如药物的生物利用度不可接受、方案频繁、患者缺乏依从性。本文将讨论壳聚糖纳米颗粒(CNPs)作为一种新的胰岛素递送载体的使用,以及它作为一种治疗形式具有提高其有效性的潜力。CNPs增强胰岛素的稳定性,使其抗酶降解;它们还允许控制释放。另一方面,它们的黏附特性延长了肠道潴留,可以促进吸收,减少给药频率,从而提高患者的依从性。同样,CNPs通过静电相互作用包裹胰岛素,可以防止胃肠道降解,同时支持持续的葡萄糖调节。此外,本研究指出,基于cnp的胰岛素递送可显著扩大血糖控制并降低低血糖风险。尽管它们具有优势,但挑战包括胰岛素释放的可变性、生产的可扩展性和监管障碍。未来的进展,如混合系统和刺激反应纳米颗粒,旨在优化稳定性和靶向胰岛素递送。将纳米医学整合到糖尿病管理中可能会彻底改变治疗方法,提供一种更有效和对患者更友好的方法。
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引用次数: 0
Stimuli-responsive nanogels in wound care: A comprehensive review 刺激反应纳米凝胶在伤口护理中的应用综述
Pub Date : 2025-01-01 DOI: 10.1016/j.nxnano.2025.100260
Tanisha Das , Mouli Das , Shirin Sultana , Rakesh Swain
Chronic wounds, including diabetic ulcers, burns, and surgical scars, fail to follow the normal stages of wound healing due to persistent inflammation, infection, and impaired tissue regeneration. Smart nanogels- stimuli-responsive, nanoscale hydrogel systems-have emerged as promising carriers for targeted and controlled drug delivery in such complex wound environments. This review highlights the structural characteristics of nanogels and critically evaluates pH, temperature, enzyme, glucose, and ROS-responsive nanogels used for wound healing. Studies show that pH-sensitive nanogels selectively release antimicrobials in acidic wound environments, while thermos-responsive formulations enhance drug release under elevated wound temperatures. Enzyme-response nanogels regulate metalloproteinase activity and promote collagen deposition. ROS-scavenging systems restore redox balance, aiding tissue repair in oxidative-stressed wounds. Glucose-responsive nanogels improve diabetic wound care by releasing insulin or antioxidants in hyperglycemic conditions. Despite their therapeutic potential, challenges remain in maintaining nanogel stability, scalability, and precise responsiveness. This review synthesizes current advancements and identifies future directions for the clinical translation of smart nanogels in chronic wound management.
慢性伤口,包括糖尿病性溃疡、烧伤和手术疤痕,由于持续的炎症、感染和组织再生受损,不能遵循伤口愈合的正常阶段。智能纳米凝胶-刺激反应,纳米级水凝胶系统-已经成为有希望的载体,在这种复杂的伤口环境中靶向和控制药物输送。这篇综述强调了纳米凝胶的结构特征,并批判性地评价了用于伤口愈合的pH、温度、酶、葡萄糖和ros反应性纳米凝胶。研究表明,ph敏感型纳米凝胶在酸性伤口环境中选择性释放抗菌剂,而热响应型纳米凝胶则在伤口温度升高的情况下增强药物释放。酶反应纳米凝胶调节金属蛋白酶活性,促进胶原沉积。活性氧清除系统恢复氧化还原平衡,帮助组织修复氧化应激伤口。葡萄糖反应纳米凝胶通过在高血糖条件下释放胰岛素或抗氧化剂来改善糖尿病伤口护理。尽管它们具有治疗潜力,但在保持纳米凝胶的稳定性、可扩展性和精确的响应性方面仍然存在挑战。这篇综述综合了目前的进展,并确定了智能纳米凝胶在慢性伤口管理中的临床翻译的未来方向。
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引用次数: 0
Piper betle infused bacterial cellulose as a bioactive material for wound healing applications 吹笛贝注入细菌纤维素作为生物活性材料的伤口愈合应用
Pub Date : 2025-01-01 DOI: 10.1016/j.nxnano.2025.100277
Samriddh Srivastava, Garima Mathur
Chronic and infected wounds present a persistent clinical challenge, often requiring advanced dressings that offer antimicrobial, antioxidative, and regenerative support. Bacterial cellulose (BC), a naturally derived biopolymer, exhibits excellent moisture retention, mechanical strength, and biocompatibility, making it a strong candidate for wound care. However, its lack of intrinsic bioactivity limits its standalone therapeutic potential. In this study, a biofunctional wound healing composite was developed by incorporating Piper betle (PB) leaf extract into BC synthesized by the high-yielding strain Komagataeibacter saccharivorans BC-G1. BC production was optimized using banana peels as a cost-effective substrate. Structural and chemical characterization via FTIR, GC-MS, and SEM confirmed successful integration of PB extract into the BC matrix, enhancing both morphology and functional properties. The modified BC demonstrated potent, broad-spectrum antibacterial activity against Escherichia coli, Pseudomonas fluorescens, and Bacillus subtilis. It also exhibited high antioxidative capacity (200 mg AAE/100 g via DPPH assay) and notable α-amylase inhibition (65 %), supporting its suitability for diabetic wound healing. Biocompatibility testing on HaCaT keratinocyte cells revealed > 80 % cell viability at therapeutic concentrations, with an IC₅₀ of 82.77 µg/mL. Furthermore, MTT and scratch assays confirmed enhanced cell proliferation and a 154 % increase in wound closure at 20 µg/mL within 48 h. These findings present a novel, scalable, and cost-effective strategy for producing multifunctional wound healing materials with combined antimicrobial, antioxidative, and regenerative properties, offering promising potential for next-generation wound care applications.
慢性和感染伤口呈现出持续的临床挑战,通常需要提供抗菌,抗氧化和再生支持的高级敷料。细菌纤维素(BC)是一种天然衍生的生物聚合物,具有优异的保湿性、机械强度和生物相容性,是伤口护理的有力候选者。然而,其缺乏内在的生物活性限制了其独立的治疗潜力。本研究以高产菌株Komagataeibacter saccharorans BC- g1合成的BC为原料,将Piper betle (PB)叶提取物掺入BC中,制备了具有生物功能的伤口愈合复合材料。以香蕉皮为底物,优化了BC的生产。通过FTIR、GC-MS和SEM对PB提取物进行了结构和化学表征,证实PB提取物成功整合到BC基质中,增强了其形态和功能特性。改性BC对大肠杆菌、荧光假单胞菌和枯草芽孢杆菌具有广谱抗菌活性。此外,它还具有较高的抗氧化能力(通过DPPH测定200 mg AAE/100 g)和显著的α-淀粉酶抑制作用(65 %),支持其适用于糖尿病伤口愈合。HaCaT角质形成细胞的生物相容性测试显示,在治疗浓度下,细胞存活率为>; 80 %,IC₅₀为82.77 µg/mL。此外,MTT和划痕实验证实细胞增殖增强,伤口愈合在48 小时内增加154 %,浓度为20 µg/mL。这些发现为生产具有抗菌、抗氧化和再生特性的多功能伤口愈合材料提供了一种新颖的、可扩展的、具有成本效益的策略,为下一代伤口护理应用提供了广阔的潜力。
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引用次数: 0
Nano-coolants for thermal enhancement in heat exchangers: A review of prospects, challenges and applications 纳米冷却剂在换热器中的热增强:前景、挑战和应用综述
Pub Date : 2025-01-01 DOI: 10.1016/j.nxnano.2025.100214
E.T. Bello , A. Nasir , A.S. Abdulkareem , M.M. Muhammadu , N.A. Musa , J.O. Tijani , Samson Oluwaseyi Bada
The demand for efficient thermal systems has driven significant interest in nano-coolants due to their superior thermal properties as alternatives to traditional coolants like water, ethylene glycol (EG), synthetic oils (polyalphaolefins), and refrigerants (R134a, R410A). These coolants face operational and environmental challenges, including low heat transfer capacity, corrosion, toxicity and ecological effects that limit their efficiency under ideal conditions because of their poor thermophysical properties, which hinder their deployment. This review provides a comprehensive analysis of the prospects, challenges and applications of nano-coolants in various heat exchanger systems. Nanoparticles such as Al2O3, ZnO, Fe3O4, SiO2 and CNTs are evaluated for their ability to enhance thermal conductivity, stability and heat transfer performance, with key factors influencing thermal enhancement, including size, shape, concentration and preparation methods, being critically examined. The study highlights applications across different heat exchanger configurations, including shell and tube, plate, double pipe, microchannel and spiral heat exchangers, which are evaluated through experimental and numerical results. Performance metrics such as Nusselt number, Reynolds number, heat transfer coefficient and overall heat transfer coefficient are discussed. In addition, the review addresses technical challenges, including agglomeration sedimentation, toxicity, increased viscosity and environmental impact, hindering widespread adoption. Furthermore, it outlines emerging prospects, including life cycle assessment, integration with renewablelar energy and the use of artificial intelligence and machine learning for predictive modeling and optimization, offering sustainable pathways for deployment and system miniaturization. The review demonstrates that, despite challenges, nano-coolants can effectively and efficiently enhance thermal exchange, impacting heat exchanger designs across various industries.
由于纳米冷却剂具有优越的热性能,可以替代传统的冷却剂,如水、乙二醇(EG)、合成油(聚α烯烃)和制冷剂(R134a、R410A),因此对高效热系统的需求推动了人们对纳米冷却剂的极大兴趣。这些冷却剂面临着操作和环境方面的挑战,包括低传热能力、腐蚀、毒性和生态影响,这些都限制了它们在理想条件下的效率,因为它们的热物理性质很差,阻碍了它们的部署。本文综述了纳米冷却剂在各种换热器系统中的应用前景、挑战和应用。纳米颗粒如Al2O3、ZnO、Fe3O4、SiO2和CNTs被评估其增强导热性、稳定性和传热性能的能力,并对影响热增强的关键因素,包括尺寸、形状、浓度和制备方法进行了严格的审查。该研究重点研究了不同换热器配置的应用,包括壳管式换热器、板式换热器、双管换热器、微通道换热器和螺旋换热器,并通过实验和数值结果进行了评估。讨论了努塞尔数、雷诺数、传热系数和总传热系数等性能指标。此外,该综述还解决了技术挑战,包括团聚沉淀,毒性,粘度增加和环境影响,阻碍了广泛采用。此外,它还概述了新兴前景,包括生命周期评估,与可再生能源的集成以及使用人工智能和机器学习进行预测建模和优化,为部署和系统小型化提供可持续的途径。研究表明,尽管存在诸多挑战,纳米冷却剂仍能有效地增强热交换,影响各行业的热交换器设计。
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引用次数: 0
Synergistic effects of Bi-metal oxide–graphene oxide nanocomposites in photodegradation applications 双金属氧化物-氧化石墨烯纳米复合材料在光降解应用中的协同效应
Pub Date : 2025-01-01 DOI: 10.1016/j.nxnano.2025.100208
Govindarajalu Kishore , Periyasamy Pritha , S. Xavier , D. Bhakiaraj , Francisxavier Paularokiadoss , Christian A. Celaya , Mohammad Mansoob Khan
The present study focuses on synthesizing two graphene-based composites, GO/CaO and GO/BaO, for photodegradation applications towards the methylene blue dye. The polycrystalline nature of the composites was determined by the XRD analysis with an average crystalline size of 14.9 nm. Raman analysis and FT-IR spectral analysis were used to determine the interaction between GO and the metal oxides. The optical band gap was evaluated to be 3.2 eV and 4.2 eV, with an absorbance λmax of around 242 nm. The PL analysis confirms the electron mobility within the composites with an emission peak of 694 nm. The elemental composition and chemical state of the composites were evaluated using XPS analysis, providing valid results for the C1s peak at 284 eV, which corresponds to the C-C and CC bonds. The photocatalytic degradation of the dye molecule was investigated by utilizing natural sunlight as the irradiation source to assess the practical applicability of the synthesized composites. The maximum degradation percentage achieved by the GO/CaO was 90 % with a period of 120 min under natural sunlight, showing a promising catalyst with a cost-effective and environmentally friendly composite for real-world wastewater treatment.
本研究的重点是合成两种石墨烯基复合材料,GO/CaO和GO/BaO,用于亚甲基蓝染料的光降解。XRD分析表明复合材料的多晶性,平均晶粒尺寸为14.9 nm。利用拉曼分析和红外光谱分析确定氧化石墨烯与金属氧化物之间的相互作用。光带隙分别为3.2 eV和4.2 eV,吸光度λmax约为242 nm。PL分析证实了复合材料内部的电子迁移率,发射峰为694 nm。利用XPS分析对复合材料的元素组成和化学状态进行了评价,得到了284 eV的C1s峰,对应于C-C和CC键。利用自然光作为照射源,研究了染料分子的光催化降解,评价了合成的复合材料的实用性。在自然光照下,氧化石墨烯/CaO的最大降解率为90 %,降解时间为120 min,这表明氧化石墨烯/CaO是一种具有成本效益和环境友好性的复合催化剂,有望用于实际废水处理。
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引用次数: 0
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Next Nanotechnology
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