Pharmacological Research - Modern Chinese Medicine最新文献

{"title":"Qingyi decoction modulates fibrotic pathways in severe acute pancreatitis: A histological and molecular study","authors":"Shayan Chen ,&nbsp;Zhihuang Wu ,&nbsp;Wendie Yu ,&nbsp;Di Zou ,&nbsp;Jiongtang Lu","doi":"10.1016/j.prmcm.2025.100684","DOIUrl":"10.1016/j.prmcm.2025.100684","url":null,"abstract":"<div><h3>Background</h3><div>Qingyi Decoction (QYD), a traditional Chinese medicine (TCM) formulation derived from Dachaihu Decoction, is used to treat severe acute pancreatitis (SAP). While QYD's components, <em>rhubarb</em> and <em>bupleurum</em>, possess known anti-fibrotic properties, their mechanisms in SAP remain unclear. This study investigated QYD's anti-fibrotic effects and underlying mechanisms in a lipopolysaccharide (LPS)- and cerulein-induced mouse model of SAP.</div></div><div><h3>Methods</h3><div>SAP was induced in mice by intraperitoneal injection of cerulein and LPS. The QYD+SAP group received oral administration of QYD at twice the clinical dosage. Following modeling and QYD treatment, pancreatic tissues were harvested for examination of fibrotic parameters using histological methods. Additionally, the anti-fibrogenic effects of QYD on pancreatic tissue were investigated using Western blotting and laser scanning confocal microscopy.</div></div><div><h3>Results</h3><div>In SAP mice, histological examination of pancreatic tissues revealed significant tissue damage. However, QYD treatment ameliorated the histological severity of SAP. Furthermore, QYD decreased the expression of pancreatic fibrosis and PSC activation markers, including α-SMA, collagen, and fibronectin, while enhancing pancreatic acinar cell survival and restoring exocrine pancreatic function. Mechanistically, QYD treatment inhibited the activation of JNK, ERK, and p38 MAPK pathways, as well as prevented IκBα degradation in pancreatic tissues.</div></div><div><h3>Conclusion</h3><div>This study demonstrates the presence of mild pancreatic fibrosis in SAP and reveals QYD's anti-fibrotic effects through the inhibition of JNK, ERK, and p38 MAPK signaling pathways and the prevention of IκBα degradation.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100684"},"PeriodicalIF":0.0,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145107939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the efficacy and safety of traditional Chinese medicine for cancer-related fatigue in lung cancer patients: A comprehensive meta-analysis of randomized controlled trials","authors":"Jingya Yang ,&nbsp;Yuxiao Li ,&nbsp;Yurou Li ,&nbsp;Menghuan Song ,&nbsp;Hao Hu ,&nbsp;Carolina Oi Lam Ung","doi":"10.1016/j.prmcm.2025.100683","DOIUrl":"10.1016/j.prmcm.2025.100683","url":null,"abstract":"<div><h3>Background</h3><div>Cancer-related fatigue (CRF) is a persistent condition that significantly impacts the health of lung oncology patients. While the conventional and non-pharmacological therapy for CRF remain uncertain, traditional Chinese medicine (TCM) has become a trending option. This study aimed to assess the efficacy and safety of TCM for CRF in lung cancer from randomized controlled trials (RCTs).</div></div><div><h3>Methods</h3><div>According to PRISMA guidelines, seven databases were searched up to 30 June 2024. Only TCM interventions were eligible in this review. Meta-analysis and network meta-analysis (NMA) were designed to pool outcomes results and compared various TCM interventions. The CONSORT-CHM and Risk of Bias tool were used to evaluate the quality and potential biases.</div></div><div><h3>Results</h3><div>This review included 41 RCTs. Compared with the routine treatment (RT), TCM + RT had significant improved efficacy rate (Risk Ratio (RR) = 1.333, 95 % Confidence Intervals (CI): 1.227 to 1.448, <em>P</em> &lt; 0.01), Karnofsky Performance Status scores (KPS) (Mean Difference (MD) = 7.182, 95 % CI: 4.160 to 10.203, <em>P</em> &lt; 0.01) and Quality of Life Questionnaires-C30 scores (QLQ-30) (MD = 9.186, 95 % CI: 6.707 to 11.665, <em>P</em> &lt; 0.01). Also, TCM + RT showed significance in reducing Piper Fatigue Scale scores (PFS) (MD = -1.145, 95 % CI: -1.452 to -0.838, <em>P</em> &lt; 0.01), Cancer-Fatigue Scale scores (MD = -6.411; 95 %CI: -8.837 to -3.985; <em>P</em> &lt; 0.01) and Brief Fatigue Inventory scores (MD = -1.687; 95 %CI: -2.350 to -1.023; <em>P</em> &lt; 0.01). From NMA results, Jianpi Yiqi Huatan Formula + RT was the best for improving efficacy rate, Kangai Injection + RT excelled in reducing PFS scores and enhancing QLQ-C30 scores, and Aidi Injection + RT was the most effective in elevating KPS scores. No serious adverse events were reported. However, poor RCTs quality and uncertain bias risk were common in this study.</div></div><div><h3>Conclusion</h3><div>Our study showed that TCM was effective and safe for CRF in lung cancer. However, given the poor quality and uncertain risk of bias, the results should be interpreted cautiously. More standardized RCTs are needed in the future.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100683"},"PeriodicalIF":0.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Progress in the application of AI in the standardization of traditional Chinese medicine: Discussion and prospects","authors":"James O. Fajemiroye","doi":"10.1016/j.prmcm.2025.100681","DOIUrl":"10.1016/j.prmcm.2025.100681","url":null,"abstract":"","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100681"},"PeriodicalIF":0.0,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trypanocidal potentials of Jatropha curcas L. 1753 leaf extracts and fractions in vivo","authors":"Haolat Yusuf ,&nbsp;Abdulhakeem Binhambali ,&nbsp;Mutiu Olawale Rahmon ,&nbsp;Ridwan Bolaji Yusuf ,&nbsp;Suleiman Garba Salihu ,&nbsp;Barnabas Jarumi Musa","doi":"10.1016/j.prmcm.2025.100670","DOIUrl":"10.1016/j.prmcm.2025.100670","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Trypanosomiasis is a debilitating parasitic disease affecting both humans and animals, leading to substantial economic losses in the livestock sector due to reduced productivity and increased mortality. As resistance to conventional drugs escalates, interest in plant-based alternatives has grown. &lt;em&gt;Jatropha curcas&lt;/em&gt; (JC), widely used in traditional medicine systems including Traditional Chinese Medicine (TCM), has demonstrated promising anti-trypanosomal activity. It is known as mǎfēng shù (麻风树) or “Leprosy Tree’’ in TCM and its varies potential has been widely described in various studies. However, this study specifically evaluated the therapeutic potential of various JC aqueous extracts on weight, body temperature, and parasitaemia levels in &lt;em&gt;Trypanosoma congolense&lt;/em&gt;-infected mice.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Ninety mice were randomly assigned to 8 (groups 4–8 have 3 subgroups) experimental groups. Mice in all groups, except the control, were inoculated with &lt;em&gt;Trypanosoma congolense&lt;/em&gt; (TC) and treated with Diminazene aceturate (DA) and varying doses of aqueous, methanol, and solvent fractions of JC extracts. Parasitaemia was monitored daily, and blood samples were collected for hematological analysis. Tissue (spleen and liver) were accessed for changes in microscopic examination.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Result&lt;/h3&gt;&lt;div&gt;The results indicated no statistically significant weight changes between treatment groups (&lt;em&gt;p&lt;/em&gt; &gt; 0.05), although slight fluctuations in weight were observed across groups. Similarly, the treatment had minimal effects on body temperature, with no significant differences observed across groups (&lt;em&gt;p&lt;/em&gt; &gt; 0.05). On parasitaemia, aqueous extracts at higher doses (of 80 and 40 mg/kg) significantly reduced parasitaemia (&lt;em&gt;p&lt;/em&gt; &lt; 0.05) compared to controls, particularly between 2–6 days. Methanol and ethyl acetate extracts also showed significant parasitaemia reduction (&lt;em&gt;p&lt;/em&gt; &lt; 0.05), with the 15 mg/kg methanol dose demonstrating the highest efficacy. However, butanol and hexane extracts did not significantly reduce parasitaemia (&lt;em&gt;p&lt;/em&gt; &gt; 0.05) and many of the tissues showed different changes on histological analysis.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;This study demonstrates that JC extracts, particularly aqueous, methanol, and ethyl acetate, exhibit significant anti-trypanosomal activity, by reducing parasitaemia levels in infected mice, likely due to the presence of bioactive phytochemicals such as alkaloids, flavonoids, and saponins. Although the extracts did not completely eliminate the parasites like common drug, however they contributed to improvements in weight, packed cell volume (PCV), red blood cell counts and histological changes, proving their potential therapeutic effects when used appropriately. Also, toxicity concerns, evidenced by the observed histology changes in higher-dose groups, warrant further investigation. The study s","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"16 ","pages":"Article 100670"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plumbagin attenuates neuropathic pain via inhibition of spinal astrogliosis and modulation of hippocampal CA1 opioidergic receptors","authors":"Prashant N. Amale ,&nbsp;Rajesh R. Ugale ,&nbsp;Ashish P. Bharne ,&nbsp;Sapan K. Shah ,&nbsp;Shilpa A. Deshpande ,&nbsp;Kartik T. Nakhate","doi":"10.1016/j.prmcm.2025.100679","DOIUrl":"10.1016/j.prmcm.2025.100679","url":null,"abstract":"<div><h3>Introduction</h3><div>Plumbagin (PL), a natural phytochemical obtained from <em>Plumbago zeylanica</em> roots, known as <em>Bai Hua Dan in</em> traditional Chinese medicine, has become a thriving area of research. Emerging evidence suggests that PL exhibits analgesic effects in various rodent pain models. Therefore, exploring the mechanisms underlying PL's central antinociceptive effect is interesting. Despite extensive research into alternative therapies, chronic neuropathic pain (NP) remains a persistent clinical challenge. We investigated the role of spinal astrogliosis and hippocampal opioid receptors in the antinociceptive action of PL in rats with chronic constriction injury (CCI) of sciatic nerve-induced NP.</div></div><div><h3>Methods</h3><div>A CCI of the sciatic nerve was performed to induce NP in rats. PL (1–8 µg/rat, intracerebroventricular-4 V) and opioid antagonist naloxone (1–8 µg/rat, intra-hippocampal cornu ammonis-1 (CA₁) were administered <em>per se</em> or in combination, followed by a thermal-mechanical-cold sensitivity test. Using a molecular docking study, the affinity of PL at opioidergic receptors was investigated. Immunohistochemistry of glial-fibrillary acidic protein (GFAP) was used to evaluate the effect of PL on astrogliosis in the spinal dorsal horn (SDH).</div></div><div><h3>Results</h3><div>Treatment with PL showed a dose-dependent antinociceptive effect. Interestingly, pretreatment with naloxone attenuated the antinociceptive effect of PL. Furthermore, PL reduced the NP-triggered integrated density of GFAP+ve astrocytes in the SDH. The <em>in-silico</em> binding revealed a potent binding of PL to kappa, delta-, and mu-opioid receptors in the order of binding, comparable to morphine.</div></div><div><h3>Conclusion</h3><div>Our findings suggest that PL possibly ameliorates NP by suppressing astroglial activation in the SDH and inhibiting nociceptive processing in the hippocampal CA₁ region via opioid receptors.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"16 ","pages":"Article 100679"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144931968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulating obesity-related metabolic dysfunction: Additive effects of Rubi fructus extract and statin in mice","authors":"Md Murad ,&nbsp;Md. Monirul Islam ,&nbsp;Nusrat Jahan Suchana ,&nbsp;Md. Mamun Or Rashid ,&nbsp;Firoz Ahmed ,&nbsp;Fahad Hussain","doi":"10.1016/j.prmcm.2025.100677","DOIUrl":"10.1016/j.prmcm.2025.100677","url":null,"abstract":"<div><h3>Introduction</h3><div>Obesity, marked by excessive adipose tissue accumulation and associated metabolic dysfunctions, remains a major global health concern. <em>Rubi fructus</em> (Chinese name: Fu-pen-zi), the fruit of plants belonging to the Rubus genus, has been traditionally used in Chinese medicine. This study investigates the anti-obesity effects of <em>Rubi fructus</em> (RF) extract and Atorvastatin (AS), both individually and in combination, using a high-fat diet (HFD)-induced obese mouse model. Materials &amp; methods: Twenty-five male Swiss albino mice were randomly assigned to five groups (normal diet, HFD, HFD+RF, HFD+RF+AS, HFD+AS) and treated over a six-week period. The RF and AS were administered at 400 and 3 mg/kg body weight. Post-treatment evaluations included measurements of body weight, abdominal fat mass, serum lipid profiles, hepatic enzyme levels, several organ weights, and expression of adipogenic and inflammatory genes.</div></div><div><h3>Results</h3><div>Both RF and AS monotherapies significantly (<em>p</em> &lt; 0.05) reduced body weight gain, abdominal adiposity, organ weight, serum triglycerides, total cholesterol, and LDL-C levels, while increasing HDL-C levels. Notably, combined administration of RF and AS produced more substantial improvements across all measured parameters. Liver function was also markedly improved, as evidenced by significant reductions in alkaline phosphatase and aspartate aminotransferase levels. Gene expression analysis demonstrated downregulation of TNF-α, MCP-1, and PPAR-γ, along with upregulation of GLUT-4 in adipose tissue, indicating attenuated inflammation and enhanced insulin sensitivity.</div></div><div><h3>Conclusion</h3><div>This study provides the first evidence for the additive anti-obesity effects of RF and AS, suggesting a promising new combination therapy for the management of obesity and its metabolic sequelae.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"16 ","pages":"Article 100677"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144931969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the cardio-protective effect of saponin-rich fraction of Dioscorea bulbifera in mitigating doxorubicin-induced cardiotoxicity in rats: A microanatomical study","authors":"Olusola Stephen Saka ,&nbsp;Omobola A Komolafe ,&nbsp;Oluwadare Ogunlade ,&nbsp;Linus A Enye ,&nbsp;Alice A Saka ,&nbsp;Mufutau O Oladimeji","doi":"10.1016/j.prmcm.2025.100678","DOIUrl":"10.1016/j.prmcm.2025.100678","url":null,"abstract":"<div><h3>Background</h3><div><em>Dioscorea bulbifera</em> bulbis contains Dioscin and diosgenin, which have been used as starting materials for various artificial steroid hormones. It also contains several saponins, flavonoids, and isoflavonoids that possess oestrogenic, heart-protective, antioxidant, and anti-cancer properties. This study investigated the effect of the saponin-rich fraction (SRF) from <em>Dioscorea bulbifera</em> bulbis on doxorubicin-induced cardiotoxicity in adult Wistar rats.</div></div><div><h3>Methods</h3><div>The rats were divided into 8 groups, with each group containing 6 rats selected at random. Group A rats were given distilled water for two weeks, while group B rats received doxorubicin (10 mg/kg/b.w, i.p. daily) for the same duration. Groups C and D were given 50 mg kg-1 and 100 mg kg-1 of SRF for the same 14-day period. Group E and Group F rats were given a combination of 10 mg/kg of doxorubicin and SRF at doses of 50 mg kg-1 and 100 mg kg-1, respectively, for 14 days. Groups G and H of rats were administered 50 mg kg-1 and 100 mg kg-1 doses for 14 days before receiving doxorubicin on day 15. The rats were sacrificed, and the heart tissue was harvested and stored in sample bottles containing 10% neutral buffer for histological and immunohistochemical studies.</div></div><div><h3>Results</h3><div>The results showed that the percentage weight change of rats in group B (-20.33 ± 0.58 g) was significantly lower (<em>F</em> = 212.1; <em>p</em> &lt; 0.0001) than the control group (18.13 ± 0.95 g) and groups C and D (14.57 ± 0.37 g and 15.21 ± 0.22 g, respectively). The photomicrograph of the control rats showed a normal, regular arrangement with clear striations of myocardial fibers. There was a distortion of the cross-banding pattern of myocardium in group B.</div></div><div><h3>Conclusion</h3><div>The study concluded that <em>Dioscorea Bulbifera</em> could reverse doxorubicin-induced cardiotoxicity in rats. Therefore, it could be employed in the management of cardiovascular-related diseases.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"16 ","pages":"Article 100678"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144922299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}