Pharmacological Research - Modern Chinese Medicine最新文献

{"title":"The use of traditional Chinese medicine in the treatment of non-alcoholic fatty liver disease: A review","authors":"Zhaolin Sun ,&nbsp;Yuhua Wei ,&nbsp;Yuchen Xu ,&nbsp;Jianwei Jiao ,&nbsp;Xiuying Duan","doi":"10.1016/j.prmcm.2024.100475","DOIUrl":"https://doi.org/10.1016/j.prmcm.2024.100475","url":null,"abstract":"<div><h3>Introduction</h3><p>Non-alcoholic fatty liver disease (NAFLD) is gradually becoming one of the most common chronic liver diseases worldwide. Compared to chemical drugs, traditional Chinese medicine (TCM) has significant advantages in the treatment of NAFLD owing to its long history, remarkable efficacy, and low toxicity.</p></div><div><h3>Methods</h3><p>The scientific databases, including PubMed, Web of Science, and China National Knowledge Infrastructure database (CNKI) were searched using the keywords of NAFLD, TCM, lipid metabolism, high-fat diet, bupleurum decoction, Yinchenhao decoction, Shugan Jiangzhi granules, Shugan Jianpi Jiangzhuo decoction, GanShuang granules, Gegen Qinlian decoction, bupleurum, Yinchen, Jiaogulan, Huangqin, Gegen, Baizhu, flavonoids, baicalein, luteolin, kaempferol, quercetin, apigenin, isorhamnetin, hesperidin, icariin, rutin, soy isoflavones, puerarin, phlorizin, total flavonoids from hawthorn leaves, and total flavonoids from buckwheat flowers and leaves to overview the pathogenesis and treatment of NAFLD.</p></div><div><h3>Results</h3><p>This review explained the causes of NAFLD, including factors like lipotoxicity, insulin resistance, ER stress, mitochondrial dysfunction, oxidative stress, gut dysbiosis, and inflammation. Furthermore, the review provided a thorough overview of the effects and mechanisms of TCM in the treatment of NAFLD. This included an analysis of six TCM formulas, six single herbs, and 14 flavonoids derived from TCM.</p></div><div><h3>Discussion</h3><p>TCM has proven to be highly effective in the treatment of NAFLD, with numerous Chinese medicine formulas and individual herbs being commonly used in clinical practice. The active components in these TCM, flavonoids, have demonstrated significant biological effects in addressing NAFLD.</p></div><div><h3>Conclusion</h3><p>TCM has the potential to greatly enhance the treatment of NAFLD with minimal adverse reactions. Given these results, we are confident that TCM holds promising opportunities for the management of NAFLD and can offer valuable perspectives for future research.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100475"},"PeriodicalIF":0.0,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001179/pdfft?md5=a130570d16a1136957c887c10b3f9b6f&pid=1-s2.0-S2667142524001179-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141540779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethanolic extract of Actinidia chinensis var. delicious fruit ameliorates scopolamine-induced cognitive impairment in rats","authors":"Shireen Ansari ,&nbsp;Sushmita Uniyal ,&nbsp;Ayushi Khali ,&nbsp;Rishabh Gaur ,&nbsp;Karabi Kalita","doi":"10.1016/j.prmcm.2024.100476","DOIUrl":"10.1016/j.prmcm.2024.100476","url":null,"abstract":"<div><h3>Aim</h3><p>The present study was to assess the anti-amnesic effect of <em>Actinidia chinensis var deliciosa</em> in a rat model of scopolamine-induced amnesia.</p></div><div><h3>Method</h3><p>36 rats were divided into 6 groups and assigned name to each group i.e. Group 1 rats (normal control) received 1 ml/kg normal saline for 14 days intraperitoneally (i.p.). Group 2 rats received scopolamine (3 mg/kg, i.p.) 30 min prior to the trial on the 14th day. Group 3 rats received 3 mg/kg/day of donepezil as pre-treatment for 14 days and scopolamine (3 mg/kg, i.p.) 30 min before the trial on the 14th day. Group 4, 5, and 6 rats received <em>Actinidia chinensis var deliciosa</em> (200, 400, and 600 mg/kg/day) for 14 days and scopolamine (3 mg/kg, i.p) 30 min before the trial on the 14th day respectively. On day 15, 6 rats from each group were sacrificed and the brain tissue of these rats was isolated for the estimation of biochemical parameters, and histopathological examination.</p></div><div><h3>Result</h3><p>Scopolamine-treated rats demonstrated increased escape latency and lipid peroxidation levels in the hippocampus compared to the control group (<em>p</em> &lt; 0.001). However, pre-treatment with <em>Actinidia chinensis var deliciosa extract (</em>ACEE) at various doses and the standard drug donepezil significantly improved these parameters. Histopathological examination revealed that ACEE and donepezil protected against pyramidal cell degeneration, neuronophagia, and vascular inflammation in scopolamine-treated rats. <em>Discussion: Actinidia chinensis var deliciosa</em> showed promising anti-amnesic activity against scopolamine-induced amnesia in rats. This could be attributed to its brain acetylcholinesterase level and alteration in neurotransmitter level.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100476"},"PeriodicalIF":0.0,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001180/pdfft?md5=9fd3f74a598a027bd869f7c3367d4c6b&pid=1-s2.0-S2667142524001180-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141960716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curcuma species DNA fingerprinting of wild and cultivated genotypes from different agroclimatic zones","authors":"Akanksha Jain ,&nbsp;Parag Jain ,&nbsp;Shaifali Mathur ,&nbsp;Dharmendra Kumar Parihar","doi":"10.1016/j.prmcm.2024.100474","DOIUrl":"https://doi.org/10.1016/j.prmcm.2024.100474","url":null,"abstract":"<div><h3>Introduction</h3><p><em>Curcuma</em> isolates from different agroclimatic zones in Chhattisgarh have been found to possess a varied spectrum of <em>Curcumin</em>, we set out to learn more about their genetic diversity by molecular fingerprinting in the present study.</p></div><div><h3>Methods</h3><p>Using SSR primers, the genetic variability of 25 <em>Curcuma genotypes</em> has been analyzed. These included the fingerprints of <em>Curcuma longa, Curcuma aromatica</em>, and <em>Curcuma caesia</em>. 13 inter simple sequence repeat (ISSR) primers amplified 107 unique fragments across all kinds, whereas 11 simple sequence repeat (SSR) primers amplified 51 unique fragments across all varieties, with 97 % and 86 % showing polymorphism, respectively.</p></div><div><h3>Results</h3><p>A total of 1080 ISSR and 567 SSR loci were amplified across all genotypes; among these, 5 monomorphic and 102 polymorphic alleles were produced in ISSR primers. However, SSR data showed 47 polymorphic and 4 monomorphic alleles. A panel of ISSR and SSR markers calculated DNA fingerprinting, genetic similarity, and distance estimates between <em>Curcuma</em> genotypes. In order to examine the diversity in different <em>Curcuma genotypes</em>, UPGMA data scoring methods were used.</p></div><div><h3>Discussion</h3><p>Curcuma species demonstrate significant genetic variability, which is essential for breeding initiatives focused on creating better cultivars with desirable characteristics such as increased productivity, resistance to diseases, and improved medicinal capabilities.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100474"},"PeriodicalIF":0.0,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001167/pdfft?md5=07c8500083576fd22e3cf17c2ac7b97d&pid=1-s2.0-S2667142524001167-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141594475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the therapeutic potential of Moringa oleifera Lam. in Traditional Chinese Medicine: A comprehensive review","authors":"Shivendra kumar ,&nbsp;Yogesh Murti ,&nbsp;Swamita Arora ,&nbsp;Wasim Akram ,&nbsp;Harsh Bhardwaj ,&nbsp;Kapil Gupta ,&nbsp;Akshaya Sachdev ,&nbsp;Jyoti Devi ,&nbsp;Santosh Kumar ,&nbsp;Bikash Kumar ,&nbsp;Vivek Dwivedi ,&nbsp;Shahnawaz Sameem ,&nbsp;Nitendra ,&nbsp;Pawan Kumar ,&nbsp;Kuldeep Singh ,&nbsp;Sunam Saha","doi":"10.1016/j.prmcm.2024.100473","DOIUrl":"https://doi.org/10.1016/j.prmcm.2024.100473","url":null,"abstract":"<div><h3>Introduction</h3><p><em>Moringa oleifera</em> Lam. (MOL), sometimes known as the drumstick tree or horseradish tree, has been extensively studied for its pharmacological properties and nutritional benefits. Recently, there has been an increased interest in using this versatile plant in Traditional Chinese Medicine (TCM) procedures. This comprehensive analysis investigates <em>Moringa oleifera's</em> therapeutic potential in TCM, focusing on its traditional usage, phytochemical composition, pharmacological activity, and possible applications in managing various health disorders.</p></div><div><h3>Methods</h3><p>We looked up online databases (PubMed, Web of Science, Google Scholar, Elsevier, ACS, Springer, CNKI) and novels for literature on <em>Moringa oleifera</em> Lam. and its pharmacological activity, using keywords like <em>Moringa oleifera,</em> biological properties of <em>Moringa</em>, and Traditional Chinese Medicine.</p></div><div><h3>Results</h3><p>We address <em>Moringa oleifera's</em> function in TCM formulations, its synergistic effects with other herbal constituents, and its compatibility with TCM principles through a literature review. Furthermore, we look at the problems and potential for bringing <em>Moringa oleifera</em> into TCM practice, such as quality control, standardisation, and cultural adaptation.</p></div><div><h3>Discussion</h3><p>This study emphasises the need for additional research and clinical investigations to fully understand <em>Moringa oleifera's</em> medicinal potential in TCM and allow its integration into modern healthcare systems. However, further research in animal models is needed to determine their efficacy and safety.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100473"},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001155/pdfft?md5=3a207a3166877c8d8691757792a43a6e&pid=1-s2.0-S2667142524001155-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141483971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Bioactivity-guided isolation followed by network pharmacology and molecular docking reveals a novel polyphenolic xanthone, β-Mangostin from Garcinia cowa leaves as a potent compound against non-small cell lung cancer” [Pharmacological Research - Modern Chinese Medicine, Volume 10, March 2024, 100367]","authors":"Anirban Chouni,&nbsp;Debarupa Hajra,&nbsp;Ribhu Ray,&nbsp;Santanu Paul","doi":"10.1016/j.prmcm.2024.100464","DOIUrl":"https://doi.org/10.1016/j.prmcm.2024.100464","url":null,"abstract":"","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100464"},"PeriodicalIF":0.0,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001064/pdfft?md5=74c6177ab5f325a5cd9d1e1c36368169&pid=1-s2.0-S2667142524001064-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141438839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-proliferative effect and mechanisms of Peony pollen on BPH via inhibition of inflammatory factors, oxidative damage and modulation of gut microbiota and SCFAs metabolism","authors":"Fan Chen ,&nbsp;Xinyue Zhang ,&nbsp;Jing Bai ,&nbsp;Xinyue Cao ,&nbsp;Le Chen ,&nbsp;Daijie Wang ,&nbsp;Sheng Guo ,&nbsp;Erxin Shang ,&nbsp;Shulan Su ,&nbsp;Jinao Duan","doi":"10.1016/j.prmcm.2024.100472","DOIUrl":"https://doi.org/10.1016/j.prmcm.2024.100472","url":null,"abstract":"<div><h3>Background</h3><p>Peony pollen (PP) has long been used as a functional food and herbal medicine. However, the potential protective effect and mechanisms of PP on benign prostatic hyperplasia (BPH) are still unclear. This study aims to explore the therapeutic effect and potential mechanisms of PP on BPH.</p></div><div><h3>Methods</h3><p>The rat model of BPH was induced by subcutaneous injection of testosterone propionate (TP). Meanwhile, the model rats were treated with PP, and physiological and biochemical indexes, the steroid 5 alpha reductase 2 (SRD5A2), proliferating cell nuclear antigen (PCNA) and androgen receptor (AR) expressions, gut microbiota and short-chain fatty acids (SCFAs) were measured.</p></div><div><h3>Results</h3><p>The results showed that the wet weight of prostate tissue and the thickness of epithelium decreased treated with PP significantly. In addition, the PP also adjusted the androgen levels, down-regulated the SRD5A2, PCNA and AR expressions, inhibited the expression of inflammatory factors including interleukin 6 (IL-6), tumor necrosis factor-<em>α</em> (TNF-<em>α</em>), interleukin 1<em>β</em> (IL-1<em>β</em>) and reduced oxidative damage in BPH rats. It is worth noting that PP can obviously regulate the gut microbiota disorder of BPH rats, increase the abundance of beneficial bacteria (e.g., <em>Romboutsia</em>), reduce the abundance of pathogenic bacteria (e.g., <em>norank_f_Oscillospiraceae</em>), and stimulate the increase of SCFAs content.</p></div><div><h3>Conclusions</h3><p>These data showed that PP can resist abnormal proliferation of the prostate by down regulation of SRD5A2, PCNA and AR expressions, attenuating oxidation stress and inflammatory damages and directly regulate the gut microbiota, especially the <em>Firmicutes</em>, and increased the level of SCFAs to ameliorate BPH. Therefore, PP might be an excellent natural plant for the development of BPH-related drugs or dietary supplements.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100472"},"PeriodicalIF":0.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001143/pdfft?md5=54a1c28f50095340f37144cf4c62bb76&pid=1-s2.0-S2667142524001143-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141483970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"6-Gingerol anti-inflammatory and antioxidant properties protect against heart and liver dysfunction in rats with sepsis","authors":"Helia Keivanpour ,&nbsp;Reihaneh Zamzam ,&nbsp;Mojtaba Mojtahedzadeh ,&nbsp;Mohammad-Reza Delnavazi ,&nbsp;Amin Sharifan ,&nbsp;Omid Sabzevari","doi":"10.1016/j.prmcm.2024.100470","DOIUrl":"https://doi.org/10.1016/j.prmcm.2024.100470","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the effect of 6-gingerol, active component of <em>Zingiber officinale (Shēngjiāng),</em> on sepsis-induced inflammation, oxidative injury, and organ damage in vivo.</p></div><div><h3>Methods</h3><p>6-gingerol was extracted from ginger, and its identity was confirmed with ¹H NMR, ¹³C NMR, and TLC. Sepsis was induced via cecal ligation and puncture (CLP) in all groups except for sham. Thirty male Wistar rats were randomly divided into sham, CLP alone, 6-gingerol, ginger extract, hydrocortisone, and solvent. Treatments were administered intraperitoneally with a dose of 25 mg/kg. Biomarkers for inflammation, oxidative injury, and organ damage were assessed. Furthermore, heart and liver organs were stained with hematoxylin-eosin to determine the extent of sepsis-induced organ damage.</p></div><div><h3>Results</h3><p>6-gingerol with 98.9 % purity was extracted. Compared with CLP-alone, biomarker analyses indicated that 6-gingerol significantly attenuated sepsis-induced inflammation by decreasing the levels of tumor necrosis factor-α, interleukin-6, and nuclear factor-κB. Furthermore, this bioactive constituent markedly reduced oxidative stress during sepsis by replenishing the levels of glutathione, increasing catalase, and decreasing malondialdehyde and superoxide. Moreover, organ damage assays showed that 6-gingerol substantially reduced the levels of cardiac troponin I, alanine aminotransaminase, aspartate aminotransferase, and lactate dehydrogenase, showing protective effects against cardiac and hepatic dysfunction. Similarly, rats treated with 6-gingerol had normal hepatic lobules, fewer Kupffer cells in minor regions of the liver, and lower necrosis and apoptosis in the myocardium.</p></div><div><h3>Discussion</h3><p>6-gingerol protects both heart and liver organs through its anti-inflammatory and antioxidant effects in septic rats.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100470"},"PeriodicalIF":0.0,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266714252400112X/pdfft?md5=09bbf4950d9f9f5b88c71592b4700ac9&pid=1-s2.0-S266714252400112X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141444233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the health beneficial properties of okanin and isookanin in human complications","authors":"Dinesh Kumar Patel","doi":"10.1016/j.prmcm.2024.100465","DOIUrl":"10.1016/j.prmcm.2024.100465","url":null,"abstract":"<div><h3>Introduction</h3><p>Herbal medicine has been used worldwide for thousands of years to treat human diseases and their associated secondary complications due to their medicinal efficacy, easy availability, and reduced side effects. <em>Coreopsis tincica</em> is a small, glabrous, aromatic annual plant with antioxidant, antihyperglycemic, and cardioprotective properties. Okanin and isookanin are an important phytochemicals of capitula of <em>Coreopsis tinctoria.</em></p></div><div><h3>Methods</h3><p>The aim of this review is to describe the medicinal efficacy, pharmacological activity, and analytical aspects of okanin and isookanin, along with their possible mechanisms of action. In the current review, we searched literature databases such as Google, Science Direct, PubMed, and Google Scholar to collect all the scientific information of okanin and isookanin. However, this review also addresses the pharmacokinetic and analytical parameters of okanin and isookanin. Scientific data on the separation, isolation, and identification of okanin and isookanin in various biological and non-biological samples are also presented here in this review.</p></div><div><h3>Results</h3><p>The scientific evidence of this review shows the biological potential of okanin and isookanin in medicine. Okanin has potential antithrombotic, antioxidant, and antihyperuricemic effects in medicine. However, okanin has potential against neurodegenerative diseases, xanthine oxidase, inducible nitric oxide synthase, <em>Candida albicans</em>, aromatase, and intestinal absorption. Furthermore, this review demonstrated the angiogenic, anti-inflammatory, antiviral, antidiabetic, and antioxidant potential of isookanin. Additionally, isookanin also has effectiveness on aromatase and amylase enzymes. This review also discusses analytical aspects of okanin and isookanin in medicine. The scientific data presented in this review also supports the traditional uses of <em>Coreopsis tinctoria</em>.</p></div><div><h3>Discussion</h3><p>Okanin and isookanin have great therapeutic potential in medicine and may be used for the development of new drugs in modern medicine. However, detailed pharmacological studies are very important for clinical applications and molecular mechanisms of okanin and isookanin in the scientific field.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100465"},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001076/pdfft?md5=97472bd928d864613a8d6540f80a0015&pid=1-s2.0-S2667142524001076-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141401383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment strategies for psoriasis using flavonoids from traditional Chinese medicine","authors":"Akash Gupta ,&nbsp;Parag Jain ,&nbsp;Kushagra Nagori ,&nbsp;Mohammad Adnan ,&nbsp;Ajazuddin","doi":"10.1016/j.prmcm.2024.100463","DOIUrl":"10.1016/j.prmcm.2024.100463","url":null,"abstract":"<div><h3>Introduction</h3><p>: The persistent inflammatory skin condition psoriasis disorder poses a significant health burden globally. This review explores recent advancements in treating psoriasis by harnessing the therapeutic potential of flavonoids, naturally occurring substances having anti-inflammatory and antioxidant.</p></div><div><h3>Methods</h3><p>The following keywords were used to search the online databases: Flavonoid, psoriasis, traditional applications, Chinese herb; Scopus, web of science, and PubMed. Consequently, this review set out to compile a synopsis of the documented phytochemistry and recent advancement of the selected plant species.</p></div><div><h3>Results</h3><p>: Specifically, flavonoids like quercetin and kaempferol have demonstrated promising results in mitigating psoriatic symptoms by targeting key molecular pathways. In conjunction with these advancements, a novel drug delivery system has been introduced to optimize flavonoid efficacy. This innovative approach employs nanocarrier systems, such as solid lipid nanoparticles (SLnp) and liposomes, to enhance the bioavailability and stability of flavonoids. By ensuring controlled release and targeted delivery, these systems address the challenges of poor solubility and maximize the therapeutic impact on psoriatic lesions. This dual strategy, integrating flavonoid-based treatment advancements with an innovative drug delivery system, presents a comprehensive and promising avenue for improving psoriasis management.</p></div><div><h3>Discussion</h3><p>: Future research and clinical validation are crucial to establishing the safety and efficacy of this integrated approach, potentially reshaping the landscape of psoriasis therapeutics.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100463"},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001052/pdfft?md5=03b8610db311a7888ceb6d667c96d9d5&pid=1-s2.0-S2667142524001052-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141400703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Herbal medicines on male reproductive system: Evidence from meta-analysis","authors":"Tung Nguyen-Thanh ,&nbsp;Phuc Dang-Ngoc ,&nbsp;Manh-Hung Bui ,&nbsp;Tam Le-Minh ,&nbsp;Quoc-Huy Nguyen-Vu","doi":"10.1016/j.prmcm.2024.100462","DOIUrl":"https://doi.org/10.1016/j.prmcm.2024.100462","url":null,"abstract":"<div><h3>Background</h3><p>The increasing prevalence of male infertility has become a global concern. Traditional Chinese and Asian medicines have long been using herbal remedies to promote spermatogenesis. This study aimed to systematically explore the potential of herbal medicines and formulations to enhance the male reproductive function in humans.</p></div><div><h3>Methods</h3><p>Two prominent databases, MEDLINE and EMBASE, as well as scientific journals indexed in the Web of Science, were used for the literature search until October 2023. The studies included in the analysis focused on the impact of herbal medicines (<em>Mucuna pruriens, Withania somnifera, Eurycoma longifolia, Panax ginseng, Lycopersicon esculentum, Crocus sativus, Vitis vinifera, Nigella sativa, Sesamum indicum, Curcuma longa, Lepidium peruvianum</em>) and Chinese and Korean Polyherbal formulations (Shao-Fu-Zhu-Yu-Tang; 少腹逐瘀汤) on human serum reproductive hormone levels, semen parameters, and antioxidant enzymes.</p></div><div><h3>Results</h3><p>A total of 23 articles were deemed eligible for the review and meta-analysis, which included 1,194 men from seven countries (China, Korea, Iran, Peru, Japan, Malaysia, and India). Of these, 19 articles were analyzed for semen parameters. The use of herbal medicine increased seminal parameters, including semen volume during each ejaculation (standardized mean difference (SMD) = 0.89; 95 % CI: 0.52, 1.26), sperm concentration (SMD = 1.97; 95 % CI: 1.30, 2.64), total sperm count (SMD = 2.28; 95 % CI: 1.44, 3.11), sperm motility (SMD = 1.07; 95 % CI: 0.68, 1.46), and normal morphology (SMD = 1.47; 95 % CI: 0.62, 2.32). Additionally, 18 articles that analyzed sex hormone levels showed that treatment with herbal medicines favorably reduced serum prolactin (SMD = -0.70; 95 % CI: -1.13, -0.28) and FSH levels (SMD = -1.07; 95 % CI: -1.56, -0.56). Meanwhile, herbal medicines did not affect testosterone levels (SMD = 0.41; 95 % CI: -0.24, 1.06) and LH levels (SMD = 0.45; 95 % CI: -0.33, 1.23). Finally, six articles were analyzed for seminal biochemical and antioxidant profiles, and the results showed that herbal medicine increased the levels of ascorbic acid (SMD = 1.19; 95 % CI: 0.51, 1.86), corrected seminal fructose (SMD = 1.32; 95 % CI: 0.89, 1.76), superoxide dismutase activity (SOD) (SMD = 1.06; 95 % CI: 0.45, 1.68), and catalase activity (SMD = 0.91; 95 % CI: 0.69, 1.44) in seminal plasma.</p></div><div><h3>Conclusion</h3><p>Herbal remedies have been found to promote spermatogenesis by optimizing semen parameters, sex hormone levels, and antioxidant profiles. As a result, these treatments should be regarded as complementary approaches to male infertility.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100462"},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001040/pdfft?md5=0f455f93afd8024c84a9bd9353f566c7&pid=1-s2.0-S2667142524001040-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141324101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}