Pharmacological Research - Modern Chinese Medicine最新文献_第9页

Emerging trends in pharmacological and therapeutic potential of glycyrrhizic acids: Traditional and nanotechnological approach 甘草酸药理和治疗潜力的新趋势：传统和纳米技术方法

Pharmacological Research - Modern Chinese Medicine

Pub Date : 2024-06-06 DOI: 10.1016/j.prmcm.2024.100461

Priyanka Jurel, Shiv Bahadur, Meenakshi Bajpai

Introduction

Glycyrrhizic acid which is the most important active ingredient extracted from the licorice root shows great potential as a carrier material in traditional chinese medicine. Nanotechnologies hold tremendous potential as an effective drug delivery system. Recent studies have indicated that the combination of glycyrrhizic acid and nanotechnology had better therapeutic effects.

Materials and methods

Literatures were searched from various databases such as PubMed, Web of Science, Scopus, Academic Journals Embase, Google Scholar and Science Direct by using keywords including like “Glycyrrhizic Acid” paired with “Traditional Chinese medicine”, “Pharmacological activities”, “Anti-tumor”, “Anti-viral”, “Hepatoprotective”, “Anti-psoriatic”, “Anti-Inflammatory”, “Nanotechnology”, or “Nanoemulsions” and their combinations, mainly from 2004 to 2024. According to the research reports, glycyrrhizic acid have a wide range of biological activities, containing anti-inflammatory, antiviral, antioxidant, gastro-protective effects, anti-obesity effects, nephroprotective effect, cardiovascular effects and hepatoprotective activity and so on.

Results

This article highlights the pharmacological properties of glycyrrhizic acid and its various potential therapeutic applications. The nanoformulation including polymeric nanoparticles, solid lipid nanoparticles, phytosomes, liposomes, nanofibers, nanoemulsions, and hydrogels, have been explored to enhance their therapeutic efficacy. These formulations may offer enhanced solubility and absorption, as well as controlled and sustained release of glycyrrhizic acid.

Conclusions

This review highlights on the recent studies for the pharmacological activities and therapeutic potential of glycyrrhizic acid, nanotechnology based drug delivery and major safety and toxicity issues glycyrrhizic acid also have been discussed.

导言：甘草酸是从甘草根中提取的最重要的活性成分，作为传统中药的载体材料具有巨大潜力。纳米技术作为一种有效的给药系统具有巨大的潜力。最近的研究表明，甘草酸与纳米技术的结合具有更好的治疗效果。材料和方法使用 "甘草酸 "配以 "传统中药 "等关键词，从 PubMed、Web of Science、Scopus、学术期刊 Embase、Google Scholar 和 Science Direct 等多个数据库中检索文献、"药理活性"、"抗肿瘤"、"抗病毒"、"保肝"、"抗银屑病"、"抗炎"、"纳米技术 "或 "纳米乳剂 "及其组合等关键词，主要研究时间为 2004 年至 2024 年。根据研究报告，甘草酸具有广泛的生物活性，包含抗炎、抗病毒、抗氧化、胃保护作用、抗肥胖作用、肾保护作用、心血管作用和肝保护活性等。为了提高甘草酸的疗效，人们探索了纳米制剂，包括聚合物纳米颗粒、固体脂质纳米颗粒、植物载体、脂质体、纳米纤维、纳米乳液和水凝胶。本综述重点介绍了有关甘草酸药理活性和治疗潜力的最新研究，还讨论了基于纳米技术的药物递送以及甘草酸的主要安全性和毒性问题。

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引用次数: 0

Daidzein in traditional Chinese medicine: A deep dive into its Ethnomedicinal and therapeutic applications 传统中药中的大黄素：深入探讨其民族药用和治疗应用

Pharmacological Research - Modern Chinese Medicine

Pub Date : 2024-06-05 DOI: 10.1016/j.prmcm.2024.100460

Neelam Singla , Gaurav Gupta , Rashi Kulshrestha , Komal Sharma , Asif Ahmad Bhat , Riya Mishra , Neeraj Patel , Riya Thapa , Haider Ali , Anurag Mishra , Rajesh Shukla , Kumud Pant , Saurabh Gupta

Introduction

Daidzein, a secondary metabolite found in Soybean (Glycine max L.) and Pueraria lobata (Willd.), plays a pivotal role in various therapeutic applications, including its potential as an anticancer agent, particularly in estrogen-dependent breast cancer, along with anti-allergic, anti-inflammatory, cardiovascular, antidiabetic, antioxidative, and neurogenerative effects. Daidzein's ability to traverse the blood-brain barrier enhances cognition, reduces aggression, and promotes locomotor activity. Its structural resemblance to estrogens positions it as a potential remedy for menopausal osteoporosis.

Methodology

The methodology for the comprehensive review on Daidzein entailed a literature search utilising keywords such as "Daidzein" and various therapeutic activities, including “Antioxidant,” “Anti-inflammatory,” “Anticancer,” “Antiviral,” “Antiobesity,” “Antidiabetic,” “Nephrotoxicity,” “Cardiovascular,” “Neuroprotective,” “Osteoporosis,” “Menopausal Symptoms,” “Aging,” “Cognitive Activities”. Academic databases such as PubMed, Google Scholar, Scopus, and Web of Science were employed for the search, considering articles published within the last 20 years to capture recent research while encompassing significant historical studies.

Results

The results provide insights into the diverse effects of daidzein across various health domains, including its antioxidant, anti-inflammatory, anticancer, antiviral, antiobesity, antidiabetic, nephrotoxicity, cardiovascular, neuroprotective, osteoporosis, menopausal symptoms, ageing, and cognitive activities.

Discussion

: The discussion section critically analyses the collective evidence gathered from the studies. It explores the mechanisms underlying daidzein's therapeutic effects and discusses the implications of these findings for both Traditional Chinese Medicine and modern healthcare practices. However, challenges related to its low bioavailability and toxicity necessitate further research, providing a foundation for future studies on daidzein's potential applications.

导言：大豆（Glycine max L.）和葛根（Pueraria lobata (Willd.)）中的一种次生代谢物--大豆苷（Daidzein）在各种治疗应用中发挥着关键作用，包括其作为抗癌剂的潜力，特别是在雌激素依赖性乳腺癌中，同时还具有抗过敏、抗炎、心血管、抗糖尿病、抗氧化和神经再生等作用。Daidzein 能够穿越血脑屏障，从而提高认知能力、减少攻击性并促进运动机能。它在结构上与雌激素相似，是治疗更年期骨质疏松症的潜在药物。研究方法对 Daidzein 进行全面综述的方法是利用 "Didzein "和各种治疗活性等关键词进行文献检索，包括 "抗氧化"、"抗炎"、"抗癌"、"抗病毒"、"抗肥胖"、"抗糖尿病"、"肾毒性"、"心血管"、"神经保护"、"骨质疏松症"、"更年期症状"、"衰老 "和 "认知活动"。搜索使用了 PubMed、Google Scholar、Scopus 和 Web of Science 等学术数据库，考虑了过去 20 年内发表的文章，以捕捉最新研究，同时涵盖重要的历史研究。结果研究结果提供了关于地丁在各个健康领域的不同作用的见解，包括其抗氧化、抗炎、抗癌、抗病毒、抗肥胖、抗糖尿病、肾毒性、心血管、神经保护、骨质疏松症、更年期症状、老龄化和认知活动：讨论部分批判性地分析了从各项研究中收集到的集体证据。讨论：讨论部分批判性地分析了从各项研究中收集到的证据，探讨了麦冬泽因治疗作用的机制，并讨论了这些发现对传统中医药和现代医疗保健实践的影响。然而，与低生物利用度和毒性有关的挑战需要进一步研究，这为今后研究麦地那龙葵素的潜在应用奠定了基础。

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引用次数: 0

"Behavioral rescue: Naringenin's neuroprotective effects against PTZ-induced seizures by mitigating oxidative stress and neuroinflammation in zebrafish larvae" "行为拯救：柚皮苷通过减轻斑马鱼幼体的氧化应激和神经炎症，对 PTZ 诱导的癫痫发作具有神经保护作用"

Pharmacological Research - Modern Chinese Medicine

Pub Date : 2024-06-04 DOI: 10.1016/j.prmcm.2024.100459

Ravikumar Manish, Durairaj Brindha, Uvarajan Deenathayalan

Introduction

Epilepsy is a complex neurological disorder affecting approximately 70 million people worldwide, accounting for about 1 % of the global population. Despite significant advancements in pharmaceutical therapies, the molecular mechanisms underlying epileptogenesis remain poorly understood, leading to symptomatic treatment being ineffective for about 30 % of patients. Recent evidence implicates oxidative stress and neuroinflammation in the pathophysiology of epilepsy. Traditional Chinese Medicine (TCM) has been used for millennia across Asia and beyond to treat conditions such as cancer, cardiovascular disorders, and neurological diseases, owing to its proven effectiveness. Naringenin is a traditional Chinese component commonly found in citrus fruits and is a naturally occurring flavonoid.

Methods

The present investigation aimed to examine the neuroprotective properties of Naringenin in mitigating PTZ-induced seizures in zebrafish larvae. Zebrafish were administered Naringenin (50 µM) for 24 h at 6 days post-fertilization (dpf), followed by exposure to 15 mM PTZ for 30 min. The study assessed c-fos expression and synaptic activity, oxidative damage, antioxidant defence mechanisms, apoptosis, and levels of nrf2, ho-1, and nqo-1 in the head regions of zebrafish larvae. Additionally, the expression of inflammatory cytokines (cox-2, tnfα, il-1β, and il-6) was evaluated.

Results

Naringenin pretreatment restored c-fos expression and synaptic activity in epileptic zebrafish larvae. The study observed high levels of oxidative damage, reduced antioxidant defences, and increased apoptosis in the larvae with epilepsy. Specifically, levels of nrf2, ho-1, and nqo-1 were decreased in the head regions of the epileptic zebrafish larvae. Naringenin administration mitigated oxidative stress, reduced neuronal apoptosis, and increased the expression of nrf2, ho-1, and nqo-1. Additionally, during seizures, inflammatory cytokines such as cox-2, tnfα, il-1β, and il-6 were upregulated, but naringenin pretreatment was shown to mitigate this effect.

Discussion

The findings collectively underscore the potential neuroprotective effects of Naringenin against PTZ-induced seizures. Naringenin modulates behavioural patterns, reduces oxidative stress, and dampens neuroinflammation, highlighting its promise as a therapeutic agent in epilepsy management. The comprehensive findings of this study serve as a foundation for further research into the mechanisms through which Naringenin confers its protective effects. Furthermore, it paves the way for exploring the potential clinical applications of Naringenin in treating epilepsy.

导言癫痫是一种复杂的神经系统疾病，影响着全球约 7000 万人，约占全球人口的 1%。尽管药物疗法取得了重大进展，但人们对癫痫发生的分子机制仍然知之甚少，导致约 30% 的患者对症治疗无效。最近的证据表明，氧化应激和神经炎症与癫痫的病理生理学有关。千百年来，传统中医药一直被用于治疗癌症、心血管疾病和神经系统疾病，其疗效已得到证实。柚皮苷是柑橘类水果中常见的一种传统中药成分，是一种天然黄酮类化合物。在受精后 6 天（dpf），给斑马鱼注射柚皮苷（50 µM）24 小时，然后将其暴露于 15 mM PTZ 30 分钟。研究评估了斑马鱼幼体头部区域的 c-fos 表达和突触活性、氧化损伤、抗氧化防御机制、细胞凋亡以及 nrf2、ho-1 和 nqo-1 的水平。结果柚皮素可恢复癫痫斑马鱼幼体中 c-fos 的表达和突触活动。研究观察到，癫痫斑马鱼幼体中氧化损伤程度高、抗氧化防御能力降低、细胞凋亡增加。具体来说，癫痫斑马鱼幼体头部区域的nrf2、ho-1和nqo-1水平下降。柚皮素能缓解氧化应激，减少神经元凋亡，并增加nrf2、ho-1和nqo-1的表达。此外，在癫痫发作期间，cox-2、tnfα、il-1β和il-6等炎性细胞因子上调，但柚皮苷预处理可减轻这种影响。柚皮苷可调节行为模式、减少氧化应激和抑制神经炎症，因此有望成为治疗癫痫的药物。这项研究的全面发现为进一步研究柚皮素的保护作用机制奠定了基础。此外，它还为探索柚皮素在治疗癫痫方面的潜在临床应用铺平了道路。

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引用次数: 0

Research of the mechanism of spatholobi caulis for immune-inflammatory of osteoarthritis based on clinical data mining,network pharmacology and cell experiment verification 基于临床数据挖掘、网络药理学和细胞实验验证的刺五加治疗骨关节炎免疫炎症的机制研究

Pharmacological Research - Modern Chinese Medicine

Pub Date : 2024-06-01 DOI: 10.1016/j.prmcm.2024.100454

Mingyu He, Jian Liu, Yanyan Fang, Yanqiu Sun, Fanfan Wang, Xu Li, Qi Han

Background

Traditional Chinese medicine is widely used in the treatment of osteoarthritis. This study explores the therapeutic effect of Traditional Chinese Medicine (TCM) on osteoarthritis (OA), as well as the mechanism by which Spatholobi Caulis (SPC) improves the immune-Inflammatory response of OA.

Methods

The clinical data mining techniques to evaluate the efficacy of Caulis spatholobi in treating OA, and elucidated its mechanism of action using network pharmacology, molecular docking, and cell experiments. The random walk model was applied to systematically evaluate the therapeutic efficacy of Chinese herbal medicine on OA.

Results

The evaluation based on the clinical data mining showed that TCM is effective in improving ESR, CRP, C3, C4, and PLT. Data mining results showed significant OA treatment. Network analysis results showed that it may fight OA by targeting JUN, ESR1 and PPARG; molecular docking results showed good JUN, ESR1, PPARG and active component formononetin. Finally, in vitro experiments conducted the preliminary validation of formononetin for the core target of FLS. Cell proliferation was measured by CCK-8, and JUN, ESR1, PPARG protein, and mRNA expression was measured by quantitative real-time RCR at 48 h after drug intervention.

Conclusion

The present study demonstrated that the SPC effectively relieved immune inflammation indicators in OA patients. Formononetin, the main active component of the chicken blood vine, acts to reduce the immune validation response in OA patients by reducing the expression of ESR1, JUN, and PPARG.

背景中医药被广泛应用于骨关节炎的治疗。本研究探讨了中药对骨关节炎（OA）的治疗作用，以及刺五加（SPC）改善 OA 免疫炎症反应的机制。结果基于临床数据挖掘的评价显示，中药对改善血沉、CRP、C3、C4和PLT有效。数据挖掘结果显示，中药对 OA 有明显的治疗作用。网络分析结果表明，它可以通过靶向 JUN、ESR1 和 PPARG 来对抗 OA；分子对接结果表明，JUN、ESR1、PPARG 和活性成分甲羧黄酮素的作用良好。最后，体外实验初步验证了福莫西汀对FLS核心靶点的作用。本研究表明，SPC能有效缓解OA患者的免疫炎症指标。鸡血藤的主要活性成分福莫西汀可通过降低 ESR1、JUN 和 PPARG 的表达来减轻 OA 患者的免疫验证反应。

{"title":"Research of the mechanism of spatholobi caulis for immune-inflammatory of osteoarthritis based on clinical data mining,network pharmacology and cell experiment verification","authors":"Mingyu He, Jian Liu, Yanyan Fang, Yanqiu Sun, Fanfan Wang, Xu Li, Qi Han","doi":"10.1016/j.prmcm.2024.100454","DOIUrl":"https://doi.org/10.1016/j.prmcm.2024.100454","url":null,"abstract":"<div><h3>Background</h3><p>Traditional Chinese medicine is widely used in the treatment of osteoarthritis. This study explores the therapeutic effect of Traditional Chinese Medicine (TCM) on osteoarthritis (OA), as well as the mechanism by which Spatholobi Caulis (SPC) improves the immune-Inflammatory response of OA.</p></div><div><h3>Methods</h3><p>The clinical data mining techniques to evaluate the efficacy of Caulis spatholobi in treating OA, and elucidated its mechanism of action using network pharmacology, molecular docking, and cell experiments. The random walk model was applied to systematically evaluate the therapeutic efficacy of Chinese herbal medicine on OA.</p></div><div><h3>Results</h3><p>The evaluation based on the clinical data mining showed that TCM is effective in improving ESR, CRP, C3, C4, and PLT. Data mining results showed significant OA treatment. Network analysis results showed that it may fight OA by targeting JUN, ESR1 and PPARG; molecular docking results showed good JUN, ESR1, PPARG and active component formononetin. Finally, <em>in vitro</em> experiments conducted the preliminary validation of formononetin for the core target of FLS. Cell proliferation was measured by CCK-8, and JUN, ESR1, PPARG protein, and mRNA expression was measured by quantitative real-time RCR at 48 h after drug intervention.</p></div><div><h3>Conclusion</h3><p>The present study demonstrated that the SPC effectively relieved immune inflammation indicators in OA patients. Formononetin, the main active component of the chicken blood vine, acts to reduce the immune validation response in OA patients by reducing the expression of ESR1, JUN, and PPARG.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"11 ","pages":"Article 100454"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524000964/pdfft?md5=40abcd37c536fef0d2a7bbee0bf6a6e3&pid=1-s2.0-S2667142524000964-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141286001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical assessment, elemental composition, and biological kinetics of Foeniculum vulgare Mill. stalks 蕨类植物茎秆的植物化学评估、元素组成和生物动力学

Pharmacological Research - Modern Chinese Medicine

Pub Date : 2024-06-01 DOI: 10.1016/j.prmcm.2024.100453

Covenant E. Ogbonna , Doga Kavaz , Yemi A. Adekunle , David B. Olawade

Introduction

The essential oil of Foeniculum vulgare (Fennel) has been extensively studied for phytochemical and elemental compositions, biochemical significance, and biological activities. However, the literature has a dearth of information on the Fennel stalk as a potential source of antioxidant and antibacterial agents. This study aimed to evaluate the phytochemical and elemental composition of Fennel stalks and also, to investigate the kinetic DPPH scavenging property and antibacterial activity of Fennel stalk extracts.

Methods

Fennel aqueous extract (FVAE) was prepared by mixing of powdered fennel stalks with sterile distilled water, followed by heating and filtration. Methanol (FVME) and ethanol (FVEE) extracts of F. vulgare were prepared by macerating the stalk with respective solvents, followed by filtration. Gas chromatography-mass spectrometry (GC–MS) analysis, Fourier Transform Infrared Spectroscopy (FTIR), determination of total phenols, and X-ray fluorescence were conducted to analyze the chemical composition of the extracts. Biological activities, including DPPH scavenging and antimicrobial activity against Methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli, were evaluated through spectrophotometric methods and well diffusion assay, respectively.

Results

The GCMS analysis revealed 15 compounds including anozol, myristyl iodine, flexiricin, dutadrupine, cycloheptaciloxane, neophytadiene, phthalic acid, and ribitol. Some of these compounds have not been reported from this plant before. FTIR analysis suggested hydroxyl (OH), alkane (CH), carbonyl (C = O), aromatic (C = C), and ether (CO) functional groups in the Fennel extracts. X-ray fluorescence identified elements including titanium, chromium, manganese, iron, nickel, copper, zinc, rubidium, and strontium. The ethanol extract had higher total phenolic content (72.45±0.01 mg GAE/g) than the aqueous (54.3 ± 0.01 mg GAE/g) and methanol (51.3 ± 0.01 mg GAE/g) extracts. In addition, a high% DPPH scavenging activity was observed in the ethanol extract (85.1 %) compared to that of ascorbic acid (96.2 %). Fennel's stalks methanol extract showed significant inhibition against the growth of E. coli 0157 and Methicillin-resistant Staphylococcus aureus B-4420, having zones of inhibition diameters of 16 mm and 13 mm, respectively. This is similar to what was observed for chloramphenicol and azithromycin.

Conclusion

The current study has demonstrated that Fennel stalks contain potentially useful antioxidant and antibacterial properties, in addition to the well-studied essential oil of its fruits and seeds.

导言：人们对茴香（Foeniculum vulgare）精油的植物化学成分和元素组成、生化意义和生物活性进行了广泛的研究。然而，有关茴香茎作为抗氧化剂和抗菌剂潜在来源的文献资料却十分匮乏。本研究旨在评估茴香茎秆的植物化学成分和元素组成，同时研究茴香茎秆提取物的动力学 DPPH 清除特性和抗菌活性。茴香甲醇提取物（FVME）和乙醇提取物（FVEE）的制备方法是用相应的溶剂浸泡茴香茎秆，然后过滤。通过气相色谱-质谱（GC-MS）分析、傅立叶变换红外光谱（FTIR）、总酚测定和 X 射线荧光法分析提取物的化学成分。结果 GCMS 分析发现了 15 种化合物，包括茴香酚、肉豆蔻基碘、柔红霉素、杜鹃花碱、环庚基硅氧烷、新茶二烯、邻苯二甲酸和核糖醇。其中一些化合物以前从未报道过来自这种植物。傅立叶变换红外分析表明，茴香提取物中含有羟基（OH）、烷基（CH）、羰基（C = O）、芳香族（C = C）和醚（CO）官能团。X 射线荧光鉴定出的元素包括钛、铬、锰、铁、镍、铜、锌、铷和锶。乙醇提取物的总酚含量（72.45±0.01 毫克 GAE/克）高于水提取物（54.3±0.01 毫克 GAE/克）和甲醇提取物（51.3±0.01 毫克 GAE/克）。此外，与抗坏血酸（96.2%）相比，乙醇提取物的 DPPH 清除活性较高（85.1%）。茴香茎秆甲醇提取物对大肠杆菌 0157 和耐甲氧西林金黄色葡萄球菌 B-4420 的生长有明显的抑制作用，抑制区直径分别为 16 毫米和 13 毫米。结论目前的研究表明，茴香茎秆除了含有研究较多的果实和种子精油外，还具有潜在的抗氧化和抗菌特性。

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引用次数: 0

Exploring the ancient wisdom and modern relevance of Chinese medicine: A comprehensive review 探索中医药的古代智慧和现代意义：全面回顾

Pharmacological Research - Modern Chinese Medicine

Pub Date : 2024-06-01 DOI: 10.1016/j.prmcm.2024.100448

Kuldeep Singh , Jeetendra Kumar Gupta , Divya Jain , Shivendra Kumar , Talever Singh , Sunam Saha

Introduction

Chinese medicine, rooted in a rich history dating back thousands of years, offers a holistic approach to healthcare that has endured the test of time. This comprehensive review explores the ancient wisdom and modern relevance of Chinese medicine, shedding light on its principles, practices, and adaptability in contemporary healthcare.

Methods

This review employs a multidisciplinary approach, drawing upon ancient texts, modern scientific research, and clinical studies to elucidate the core tenets of Chinese medicine. A comprehensive literature search was conducted in various databases, including PubMed, Web of Science, and traditional Chinese medical databases, to identify relevant articles, books, and historical documents.

Results

The review synthesizes the fundamental concepts of Chinese medicine, such as Qi, Yin-Yang, the five elements, and meridian system, while examining their physiological and clinical significance in the context of modern medicine. It also delves into the integration of Chinese Medicine into mainstream healthcare systems worldwide, highlighting its growing acceptance and utilization in the treatment of various conditions, including chronic pain, mental health disorders, and complementary cancer care.

Discussion

The discussion section explores the synergy between traditional Chinese medicine and contemporary medical practices, emphasizing the potential for a complementary approach that bridges the gap between Eastern and Western healthcare. It addresses the challenges and opportunities in integrating Chinese medicine into evidence-based medicine, emphasizing the importance of rigorous research and standardization.

Conclusion

In conclusion, this review underscores the enduring wisdom of Chinese medicine, showcasing its adaptability and relevance in the modern healthcare landscape. It advocates for continued collaboration between traditional Chinese medicine and conventional medical systems, fostering a more holistic and patient-centered approach to healthcare. By embracing the ancient wisdom of Chinese medicine alongside modern medical advancements, we can pave the way for a healthier and more balanced future.

导言中医学植根于数千年的悠久历史，提供了一种经得起时间考验的整体医疗保健方法。本综述探讨了中医药的古代智慧和现代意义，揭示了中医药的原则、实践以及在当代医疗保健中的适应性。方法本综述采用多学科方法，借鉴古代典籍、现代科学研究和临床研究来阐明中医药的核心原则。结果综述了中医学的基本概念，如气、阴阳、五行和经络系统，同时研究了它们在现代医学背景下的生理和临床意义。讨论部分探讨了传统中医药与当代医疗实践之间的协同作用，强调了在东西方医疗保健之间架起桥梁的互补方法的潜力。最后，本综述强调了中医药经久不衰的智慧，展示了其在现代医疗保健领域的适应性和相关性。它倡导传统中医药与传统医学体系继续合作，促进更加全面和以患者为中心的医疗保健方法。通过将古老的中医智慧与现代医学进步相结合，我们可以为更健康、更平衡的未来铺平道路。

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引用次数: 0

On the miRNAs-regulated mechanisms by which natural plant polysaccharides control apoptosis 天然植物多糖控制细胞凋亡的 miRNA 调控机制

Pharmacological Research - Modern Chinese Medicine

Pub Date : 2024-06-01 DOI: 10.1016/j.prmcm.2024.100456

Chong Wang , Xueqin Duan , Huicong Li , Siyu Zeng , Yang Yang , Weimin Zhang , Yingqiu Liu , Wuren Ma , Lin Ma , Yunpeng Fan

Instruction

Plant polysaccharides are important components of Chinese herbal medicine. Many polysaccharides, such as Astragalus polysaccharide and Lycium barbarum polysaccharide, have important functions such as tumor growth inhibition, antioxidant, anti-aging and immune regulation.

Methods

Literature searches were conducted on the following databases: Pubmed, ACS website, Elsevier, Google Scholar, Web of Science and CNKI database. Keywords such as “plant polysaccharides”, “apoptosis”, “miRNA”, “apoptosis pathway” and “regulation of apoptosis” were used to search relevant journals and contents, and some irrelevant contents were excluded. In this review, the effects of plant polysaccharides on cell apoptosis and how to regulate miRNA expression were reviewed, which provided the basis for further research on the mechanism of polysaccharide action.

Results

Plant polysaccharides regulated apoptosis probably by regulating the expression of mirnas, and the expression of certain downstream signaling factors of miRNA were changed. Some of these factors could directly act on apoptosis-related signals, activate or inhibit signaling pathways, and thus regulate cell apoptosis.

Discussion and conclusion

In this review, we discussed the regulatory effects of plant polysaccharides on apoptosis and their possible molecular mechanisms. However, most of the current studies lack clinical experimental data, so it is still necessary to further study the specific mechanism of plant polysaccharides affecting cell miRNA expression and apoptosis, so that plant polysaccharides can be more widely used in clinical and practical aspects.

说明植物多糖是中药的重要成分。许多多糖，如黄芪多糖和枸杞多糖，具有抑制肿瘤生长、抗氧化、抗衰老和免疫调节等重要功能：方法在以下数据库中进行文献检索：Pubmed、ACS 网站、Elsevier、Google Scholar、Web of Science 和 CNKI 数据库。使用 "植物多糖"、"细胞凋亡"、"miRNA"、"细胞凋亡途径 "和 "细胞凋亡调控 "等关键词检索相关期刊和内容，并排除了一些不相关的内容。结果植物多糖可能通过调控mirnas的表达来调控细胞凋亡，miRNA的某些下游信号因子的表达也发生了变化。讨论与结论本综述讨论了植物多糖对细胞凋亡的调控作用及其可能的分子机制。然而，目前的研究大多缺乏临床实验数据，因此仍有必要进一步研究植物多糖影响细胞 miRNA 表达和细胞凋亡的具体机制，从而使植物多糖在临床和实用方面得到更广泛的应用。

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引用次数: 0

Exploring the therapeutic potential of Madhuca longifolia in traditional Chinese medicine for the management of kidney stones and various diseases: A review 探讨马齿苋在中药中治疗肾结石及各种疾病的潜力：综述

Pharmacological Research - Modern Chinese Medicine

Pub Date : 2024-06-01 DOI: 10.1016/j.prmcm.2024.100452

Dilip Kumar Chanchal, Satish Kumar Sharma

Introduction

Kidney stones (renal calculi), are a common urological problem affecting millions worldwide. Madhuca longifolia (M. longifolia), commonly known as Mahua, has a rich history of medicinal use in various traditional systems, including Traditional Chinese Medicine (TCM). This review aims to explore the therapeutic potential of M. longifolia in the management of kidney stones through the lens of TCM.

Methods

Examination of the therapeutic efficacy of M. longifolia in the context of TCM for the treatment of kidney stones was undertaken by performing an exhaustive literature review via internet-based databases, such as PubMed, Scopus, and Google Scholar. Keywords such as "Madhuca longifolia," "Mahua," "kidney stones," "renal calculi," "Pharmacological activity," and "Traditional Chinese Medicine" were used to ensure the inclusivity of relevant literature. Studies published between 1972 and 2019 were considered. Inclusion criteria were peer-reviewed articles, systematic reviews, focusing on the health impacts of plant-based diets. Information on the subspecies and cultivars of common names and the scientific names was verified using the Plant List (www.theplantlist.org) database. We retrieved and utilised it for the review of 80 articles.

Results

The literature review revealed several studies highlighting the potential therapeutic effects of M. longifolia in the management of kidney stones. The bioactive compounds present in M. longifolia, including flavonoids, phenolic compounds, and saponins, exhibit diuretic, anti-inflammatory, and litholytic properties, which contribute to the dissolution and prevention of kidney stones. Furthermore, Madhuca longifolia demonstrates various pharmacognostic activities, reducing the risk of renal damage associated with kidney stone formation.

Discussion

Traditional Chinese Medicine recognizes M. longifolia as a valuable botanical resource for the medical management of kidney calculi. It presents a natural and comprehensive strategy for managing the intricacies associated with kidney stones.

导言肾结石（肾结石）是一种常见的泌尿系统问题，影响着全球数百万人。长叶马钱子（Madhuca longifolia），俗称马钱子，在包括中医（TCM）在内的各种传统体系中都有丰富的药用历史。本综述旨在通过中医的视角，探讨长叶马兜铃在治疗肾结石方面的治疗潜力。方法通过互联网数据库（如 PubMed、Scopus 和 Google Scholar）进行详尽的文献综述，研究长叶马兜铃在中医治疗肾结石方面的疗效。关键词包括 "Madhuca longifolia"、"Mahua"、"肾结石"、"肾结石"、"药理活性 "和 "中医"，以确保相关文献的包容性。研究考虑了 1972 年至 2019 年间发表的研究。纳入标准为同行评审文章、系统综述，重点关注植物性饮食对健康的影响。我们使用植物名录 (www.theplantlist.org) 数据库核实了常见名称和学名的亚种和栽培品种信息。结果文献综述显示，多项研究强调了 M. longifolia 在治疗肾结石方面的潜在疗效。longifolia 中的生物活性化合物，包括黄酮类化合物、酚类化合物和皂苷，具有利尿、抗炎和溶石特性，有助于溶解和预防肾结石。此外，马钱子还具有多种药理活性，可降低肾结石形成对肾脏造成损害的风险。讨论传统中医认为马钱子是治疗肾结石的宝贵植物资源。传统中医学认为，龙葵是治疗肾结石的宝贵植物资源，它提供了一种自然而全面的策略，可用于治疗与肾结石有关的复杂问题。

{"title":"Exploring the therapeutic potential of Madhuca longifolia in traditional Chinese medicine for the management of kidney stones and various diseases: A review","authors":"Dilip Kumar Chanchal, Satish Kumar Sharma","doi":"10.1016/j.prmcm.2024.100452","DOIUrl":"https://doi.org/10.1016/j.prmcm.2024.100452","url":null,"abstract":"<div><h3>Introduction</h3><p>Kidney stones (renal calculi), are a common urological problem affecting millions worldwide. <em>Madhuca longifolia</em> (<em>M. longifolia</em>), commonly known as Mahua, has a rich history of medicinal use in various traditional systems, including Traditional Chinese Medicine (TCM). This review aims to explore the therapeutic potential of <em>M. longifolia</em> in the management of kidney stones through the lens of TCM.</p></div><div><h3>Methods</h3><p>Examination of the therapeutic efficacy of <em>M. longifolia</em> in the context of TCM for the treatment of kidney stones was undertaken by performing an exhaustive literature review via internet-based databases, such as PubMed, Scopus, and Google Scholar. Keywords such as \"<em>Madhuca longifolia</em>,\" \"Mahua,\" \"kidney stones,\" \"renal calculi,\" \"Pharmacological activity,\" and \"Traditional Chinese Medicine\" were used to ensure the inclusivity of relevant literature. Studies published between 1972 and 2019 were considered. Inclusion criteria were peer-reviewed articles, systematic reviews, focusing on the health impacts of plant-based diets. Information on the subspecies and cultivars of common names and the scientific names was verified using the Plant List (www.theplantlist.org) database. We retrieved and utilised it for the review of 80 articles.</p></div><div><h3>Results</h3><p>The literature review revealed several studies highlighting the potential therapeutic effects of <em>M. longifolia</em> in the management of kidney stones. The bioactive compounds present in <em>M. longifolia</em>, including flavonoids, phenolic compounds, and saponins, exhibit diuretic, anti-inflammatory, and litholytic properties, which contribute to the dissolution and prevention of kidney stones. Furthermore, <em>Madhuca longifolia</em> demonstrates various pharmacognostic activities, reducing the risk of renal damage associated with kidney stone formation.</p></div><div><h3>Discussion</h3><p>Traditional Chinese Medicine recognizes <em>M. longifolia</em> as a valuable botanical resource for the medical management of kidney calculi. It presents a natural and comprehensive strategy for managing the intricacies associated with kidney stones.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"11 ","pages":"Article 100452"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524000940/pdfft?md5=4b2dcd586836bec8e6befc9216b211f5&pid=1-s2.0-S2667142524000940-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical efficacy and safety of 16 Chinese patent medicines in combination with benzodiazepines/non-benzodiazepines for the treatment of chronic insomnia in adults: A multiple-treatment meta-analysis 16种中成药联合苯二氮卓类药物/非苯二氮卓类药物治疗成人慢性失眠症的临床疗效和安全性：多重治疗荟萃分析

Pharmacological Research - Modern Chinese Medicine

Pub Date : 2024-06-01 DOI: 10.1016/j.prmcm.2024.100449

Ciyan Peng , Jing Chen , Sini Li , Boyin Huang , Wei Cui , Jianhe Li , Liubao Peng

Introduction

Chronic insomnia in adults affects the health and quality of life of patients. Chinese patent medicines (CPMs) combined with benzodiazepines/non-benzodiazepines (BZDs/N-BZDs) are used frequently in routine clinical practice. However, evidence on the efficacy and safety of these combined interventions is lacking. A multiple treatment meta-analysis (MTMA) was conducted to evaluate the comparative efficacy and safety of 16 CPMs combined with BZDs/N-BZDs for the treatment of chronic insomnia in adults.

Methodology

We systematically reviewed 171 randomized controlled trials (RCTs) involving 16,874 participants (8506 in intervention groups and 8368 in control groups) from the inception of several databases to 2023. This review encompassed electronic databases, regulatory-agency websites, and international registers of published trials involving adult patients with chronic insomnia who received CPM + BZDs/N-BZDs therapies. A random-effects MTMA was undertaken using Stata/MP17, RevMan (5.3), and R. Outcome measures were the Pittsburgh Sleep Quality Index (PSQI), overall efficacy rate, as well as the incidence of dry mouth, dizziness, and somnolence.

Results

Our MTMA showed that BZD/N-BZD therapy as a co-intervention for Tianmengjiaonang (TMJN) was likely to be the optimal option for improving the PSQI (surface under the cumulative sorting curve (SUCRA) = 95.00 %), whereas shensongyangxinjiaonang (SSYXJN) had the highest probability of improving overall effectiveness (SUCRA = 88.20 %). Jiaotaiwan (JTW), Bailemian (BLMJN), and Wulinjiaonang (WLJN) had the highest probability of reducing the incidence of somnolence (SUCRA = 90.00 %), dry mouth (SUCRA = 72.90 %), and dizziness (SUCRA = 84.40 %).

Conclusions

All CPMs in combination with BZDs/N-BZDs were more efficacious and safer than using BZDs/N-BZDs alone in adults with chronic insomnia. SSYXJN + BZDs/N-BZDs and TMJN + BZDs/N-BZDs are likely to be optimal CPMs because they improve overall efficacy and sleep quality and reduce the risk of adverse effects. However, the effects of these interventions may vary from person to person. Hence, patients, carers, and clinicians should carefully consider the efficacy, safety, and risk–benefit profile of all active interventions for patients with insomnia based on real-world data.

导言：成年人长期失眠会影响患者的健康和生活质量。中成药与苯二氮卓类/非苯二氮卓类（BZDs/N-BZDs）的联合治疗在常规临床实践中经常使用。然而，有关这些联合干预措施的疗效和安全性的证据还很缺乏。我们系统回顾了从多个数据库建立之初到 2023 年的 171 项随机对照试验 (RCT)，涉及 16874 名参与者（干预组 8506 人，对照组 8368 人）。该综述涵盖了电子数据库、监管机构网站和国际登记册中已发表的涉及接受CPM+BZDs/N-BZDs疗法的成年慢性失眠症患者的试验。结果测量指标为匹兹堡睡眠质量指数（PSQI）、总体有效率以及口干、头晕和嗜睡的发生率。结果我们的MTMA显示，BZD/N-BZD疗法作为天梦娇娘（TMJN）的联合干预，可能是改善PSQI的最佳选择（累积排序曲线下表面值（SUCRA）= 95.00 %），而神农心脑血管病（SSYXJN）改善总有效率的可能性最大（SUCRA = 88.20 %）。交泰丸（JTW）、百乐眠（BLMJN）和武陵娇娘（WLJN）降低嗜睡（SUCRA = 90.00 %）、口干（SUCRA = 72.结论在慢性失眠症成人患者中，所有 CPMs 与 BZDs/N-BZDs 联用比单独使用 BZDs/N-BZDs 更有效、更安全。SSYXJN+BZDs/N-BZDs和TMJN+BZDs/N-BZDs可能是最佳的CPM，因为它们能提高总体疗效和睡眠质量，并降低不良反应的风险。然而，这些干预措施的效果可能因人而异。因此，患者、照护者和临床医生应根据真实世界的数据，仔细考虑所有失眠患者积极干预措施的疗效、安全性和风险收益情况。

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引用次数: 0

Computational investigation of Y. aloifolia variegate as anti-Human Immunodeficiency Virus (HIV) targeting HIV-1 protease: A multiscale in-silico exploration 以 HIV-1 蛋白酶为目标的 Y. aloifolia variegate 抗人类免疫缺陷病毒（HIV）的计算研究：多尺度实验室内探索

Pharmacological Research - Modern Chinese Medicine

Pub Date : 2024-06-01 DOI: 10.1016/j.prmcm.2024.100451

Riyan Alifbi Putera Irsal , Gusnia Meilin Gholam , Maheswari Alfira Dwicesaria , Fernanda Chairunisa

Introduction

Human Immunodeficiency Virus (HIV) is a global challenge for the health sector due to the absence of a definitive cure. More than 38 million people are affected by the disease worldwide, with approximately 1.5 million new cases reported annually. This situation has spurred continued efforts in searching for drug candidates. Meanwhile, rutin, luteolin, and quercetin are compounds known for efficacy in treating infectious diseases. The compounds have also been detected in Yucca aloifolia (絲蘭) variegate L. Therefore, this study aimed to conduct a computational investigation utilizing multiscale in silico exploration to assess the potential of Y. aloifolia as an anti-HIV agent targeting HIV-1 Protease (H1P).

Methods

For the in silico study, the three-dimensional structure of H1P (PDB: 5V4Y) was retrieved and prepared using YASARA Structure. The binding pockets were identified using Cavity Plus server, and ligands were obtained from Y. aloifolia leaves alcohol extract. Furthermore, molecular docking was conducted with YASARA Structure to predict binding energies, followed by QSAR analysis for activity prediction. Density Functional Theory (DFT) analysis was performed to assess stability and reactivity, while toxicity was evaluated using ProTox 3.0. Molecular dynamics (MD) simulation and Molecular Mechanics Poisson–Boltzmann Surface Area (MM-PBSA) calculation were also conducted for further analysis.

Results

The results showed that Ramachandran plot analysis indicated favorable residue distribution based on the evaluation of enzyme preparation quality. Cavity Plus identified potential binding sites, with cavity no.2 showing the highest druggability. Molecular docking showed rutin and isorhamnetin-3-O-rutinoside as top binders to H1P, with favorable binding energies. Moreover, post-docking analysis produced specific interactions between ligands and the receptor. PASS prediction indicated the potential of rutin and isorhamnetin-3-O-rutinoside (narcissin) as H1P inhibitors. DFT analysis assessed stability, showing comparable values for the investigated compounds. Toxicity analysis suggested both compounds to be non-toxic. Finally, MD simulation demonstrated the superior stability and binding affinity of rutin compared to isorhamnetin-3-O-rutinoside and the control drug, grl-09510.

Discussion

Rutin, hecogenin, and isorhamnetin-3-O-rutinoside from Y. aloifolia (絲蘭) leaves showed potential as H1P inhibitors through in silico study. Docking simulations indicated that rutin had the most favorable binding interactions, while MD simulation showed only the rutin-H1P complex to be stable, signifying the potential for further drug development. Rutin was identified as a promising lead for H1P inhibition due to its strong binding, stability, and predicted safety prope

导言人类免疫缺陷病毒（HIV）是卫生部门面临的一项全球性挑战，因为目前还没有确切的治疗方法。全世界有 3800 多万人受到这种疾病的影响，每年新增病例约 150 万例。这种情况促使人们继续努力寻找候选药物。同时，芦丁、木犀草素和槲皮素是已知具有治疗传染性疾病功效的化合物。因此，本研究旨在利用多尺度硅学探索进行计算研究，评估丝兰作为针对 HIV-1 蛋白酶（H1P）的抗艾滋病药物的潜力。利用 Cavity Plus 服务器确定了结合口袋，并从娑罗子叶醇提取物中获得了配体。此外，还利用 YASARA Structure 进行了分子对接以预测结合能，然后进行了 QSAR 分析以预测活性。密度泛函理论（DFT）分析用于评估稳定性和反应性，而毒性则使用 ProTox 3.0 进行评估。此外，还进行了分子动力学（MD）模拟和分子力学泊松-波尔兹曼表面积（MM-PBSA）计算，以进一步分析。结果结果表明，拉马钱德兰图分析表明，基于酶制剂质量评估的残留物分布情况良好。Cavity Plus 确定了潜在的结合位点，其中 2 号空穴显示出最高的药物可结合性。分子对接显示，芦丁和异鼠李素-3-O-芸香糖苷是 H1P 的最佳结合剂，具有良好的结合能量。此外，对接后分析显示配体与受体之间存在特定的相互作用。PASS 预测表明芦丁和异鼠李素-3-O-芸香糖苷（水苏糖苷）具有作为 H1P 抑制剂的潜力。DFT 分析评估了稳定性，结果显示所研究化合物的稳定性值相当。毒性分析表明这两种化合物都是无毒的。最后，MD 模拟表明，与异鼠李素-3-O-芸香糖苷和对照药物 grl-09510 相比，芦丁具有更高的稳定性和结合亲和力。对接模拟显示芦丁具有最有利的结合相互作用，而 MD 模拟显示只有芦丁-H1P 复合物是稳定的，这表明芦丁具有进一步开发药物的潜力。由于芦丁具有很强的结合力、稳定性和预测的安全性，它被确定为一种有希望抑制 H1P 的先导化合物，这突出了进行湿实验室验证的必要性。

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引用次数: 0

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