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Application of UV spectrophotometric method to study stress degradation behavior of cefprozil 紫外分光光度法研究头孢丙烯的应力降解行为
Pub Date : 2013-07-01 DOI: 10.4103/2229-5186.115557
Kiran Jadhav, Dinesh Dhamecha, G. Asnani, Vrushali S Bhalekar, S. Lahoti
Background: Cefprozil is a bactericidal drug that is used in the treatment of susceptible infections including upper and lower respiratory tract infections and skin and soft tissue infections. Materials and Methods: The objective of this research work was to develop and validate new, simple ultraviolet (UV) spectrophotometric method of Cefprozil in bulk and pharmaceutical dosage form and its application to study its stress degradation behavior. Results: The absorbance maxima peak was found at 280 nm, and linearity was observed in the concentration range of 2-10 μg/ml. The method was validated and found to be precise. Accuracy (percent recovery) for Cefprozil was found to be 99.117±1.005. Conclusion: A new method for estimation of Cefprozil by UV spectrophometry was developed and validated and Cefprozil was found to undergo degradation in all stress conditions.
背景:头孢丙烯是一种用于治疗易感感染的杀菌药物,包括上呼吸道感染、下呼吸道感染和皮肤软组织感染。材料与方法:本研究的目的是建立和验证一种新的、简单的紫外分光光度法测定头孢丙烯原料药和药料药的方法,并应用该方法研究头孢丙烯的应力降解行为。结果:吸光度峰在280 nm处出现,在2 ~ 10 μg/ml浓度范围内呈线性关系。结果表明,该方法是精确的。头孢丙烯的准确度(回收率)为99.117±1.005。结论:建立并验证了紫外分光光度法测定头孢丙烯的新方法,头孢丙烯在各种应激条件下均可降解。
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引用次数: 6
Argon green-Nd: YAG dual laser posterior hyaloidotomy: An innovative approach toward treatment of premacular hemorrhage 氩绿- nd: YAG双激光后玻璃体切开术:一种治疗黄斑前出血的创新方法
Pub Date : 2013-07-01 DOI: 10.4103/2229-5186.115559
Ashish Sharma, J. Sheth
Background: Neodymium: YAG (Nd: YAG) laser and argon laser has been used to treat premacular hemorrhage either alone or rarely in combination. Materials and Methods: We describe a new technique of treating premacular hemorrhage by performing hyaloidotomy using a combination of argon green-Nd: YAG laser. We utilized subthreshold energy levels of Nd: YAG laser of 2.0 mJ as compared to the normal recommendation of 3.6-50 mJ. Results and Conclusions: This technique is easy, effective, and safe to manage premacular hemorrhage. The principle behind this combined laser treatment was to make the internal limiting membrane (ILM) taut by initial exposure to argon green laser, which allowed us to employ the subthreshold energy levels of Nd: YAG laser. We would like to assess the role of this combined treatment modality in comparison to other modalities, including solitary laser therapy in the management of premacular hemorrhage by performing a prospective, randomized long-term study.
背景:钕钇铝石榴石(Nd: YAG)激光和氩激光已被单独或罕见地联合用于治疗黄斑前出血。材料和方法:我们描述了一种治疗黄斑前出血的新技术,即使用氩绿- nd: YAG激光联合进行玻璃体切开术。我们使用了2.0 mJ的Nd: YAG激光的亚阈值能级,与正常推荐的3.6-50 mJ相比。结果与结论:该方法治疗黄斑前出血简便、有效、安全。这种联合激光治疗的原理是通过初始暴露于氩绿激光使内部限制膜(ILM)绷紧,这使我们能够使用Nd: YAG激光的亚阈值能级。我们希望通过一项前瞻性、随机的长期研究来评估这种联合治疗方式与其他治疗方式的作用,包括单独激光治疗在黄斑前出血的治疗中。
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引用次数: 2
Sleep quality and sleep associated problems in female pharmacy students 药学女生睡眠质量及睡眠相关问题研究
Pub Date : 2013-07-01 DOI: 10.4103/2229-5186.115553
Vivek Jain, Renu Tomar, J. Jha, Ashuthosh Pareek, Y. Ratan, N. Paliwal
Background: Sleep is an essential element for adolescent mental and physical growth and development, but today's young adolescents are deprived of this. Earlier studies in Europe and America showed pitiable sleep quality of young college students, which affect their academic growth. However, as per our literature search there is a lack of such studies in Indian context especially, within pharmacy education. Objective: The present study was designed to investigate the interrelation between the demographic characteristics, life-style, and academic progress with sleep quality and sleep problems along with daytime and nighttime habits in young female pharmacy students of India. Materials and Methods: Questionnaire on sleep and daytime habits (QS and DH) was prepared. Our sample survey consists of 226 female pharmacy students of Banasthali University. QS and DH of multiple choice type, covered demographic characteristic (3 questions) sleep and daytime habits (25 questions), life-style and academic progress (3 questions), and one question of course curriculum. Parameters were co-related by point scale method using the SPSS 16.0 software. Results: Data derived and analyze from survey illustrated that quality of sleep was as: Excellent - 20.4%, good - 38.5%, satisfactory - 35.8%, poor - 4%, and very poor - 1.3% of participants. Living condition ( ρ =0.168, P =0.011), academic progress ( ρ =0.151, P=0.023), leisure activity ( ρ =0.133, P ρ =0.160, P=0.016) were significantly correlated with sleep quality. In addition, daytime sleepiness caused a significant problem for students and created a number of sleep disorders. Nevertheless, Sleep quality was not associated with age, body mass index, and coffee in the late evening. Conclusion: Study reported that sleep associated problems were common complaints in female pharmacy students.
背景:睡眠是青少年身心成长和发展的基本要素,但今天的年轻青少年被剥夺了这一点。欧美早前的研究表明,年轻大学生的睡眠质量很差,影响了他们的学业成长。然而,根据我们的文献检索,在印度背景下缺乏这样的研究,特别是在药学教育方面。目的:本研究旨在探讨印度年轻女药学专业学生的人口学特征、生活方式、学业进展与睡眠质量、睡眠问题以及昼夜习惯的相互关系。材料与方法:编制睡眠与日间习惯问卷(QS和DH)。样本调查对象为班纳斯塔利大学药学专业女学生226名。QS和DH为选择题,包括人口统计特征(3题)、睡眠和白天习惯(25题)、生活方式和学业进展(3题)、课程设置(1题)。采用SPSS 16.0软件,采用点比例尺法进行参数相关分析。结果:调查数据得出和分析表明,睡眠质量为:优秀(20.4%),良好(38.5%),满意(35.8%),差(4%),非常差(1.3%)。生活条件(ρ =0.168, P= 0.011)、学业进展(ρ =0.151, P=0.023)、休闲活动(ρ =0.133, P= 0.160, P=0.016)与睡眠质量显著相关。此外,白天嗜睡对学生造成了严重的问题,并造成了许多睡眠障碍。然而,睡眠质量与年龄、体重指数和深夜喝咖啡无关。结论:研究报告睡眠相关问题是药学女学生的常见主诉。
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引用次数: 6
Burn wound: Pathophysiology and its management by herbal plants 烧伤创面:病理生理及草药治疗
Pub Date : 2013-07-01 DOI: 10.4103/2229-5186.115537
D. Kaushik, Shiwani Kamboj, P. Kaushik, Shivkant Sharma, A. Rana
In human body, wound healing is a normal biological phenomenon. Burns may be acute or chronic depending upon the source and its time of exposure. Burn wounds may be superficial, partial or full thickness wounds. When skin comes in contact with higher temperature, protein denaturation takes place due to which the plasma membrane integrity is lost. When skin is burned, a number of inflammatory mediators and releasing agents such as histamine, nitric oxide, oxygen free radicals, eicosanoid products, tumor necrosis factors, and interleukins etc., are released at the site. For wound healing mechanism, the keratinocytes has to move from uninjured site to the burned area. For deeper burns this process takes a long time. By some unknown mechanisms, burn wounds may convert from one form to another form. So burn wound depth must be accurately measured before starting the treatment to prevent the complications. Burns can be induced in experimental animals by using different models. Many treatments such as herbal drugs, topical agents, gene therapy, volume therapy, and rehabilitation can be employed. This review article mainly deals with the theoretical and practical aspects of burn wound healing. Some burn wound healing plants with their chemical constituents, plant part used, uses and animal models are described here.
在人体中,伤口愈合是一种正常的生物现象。烧伤可分为急性或慢性,取决于其来源和暴露时间。烧伤创面可能是浅表、局部或全层创面。当皮肤接触到较高的温度时,蛋白质会发生变性,从而使质膜的完整性丧失。当皮肤被烧伤时,许多炎症介质和释放剂如组胺、一氧化氮、氧自由基、类二十烷产物、肿瘤坏死因子、白细胞介素等在烧伤部位被释放。对于伤口愈合机制,角化细胞必须从未受伤部位移动到烧伤区域。对于深度烧伤,这个过程需要很长时间。通过一些未知的机制,烧伤伤口可以从一种形式转变为另一种形式。因此,在开始治疗前必须准确测量烧伤创面深度,以防止并发症的发生。实验动物可以通过使用不同的模型来诱导烧伤。许多治疗方法,如草药、局部药物、基因治疗、容量治疗和康复治疗都可以使用。本文主要从烧伤创面愈合的理论和实践两方面进行综述。本文介绍了几种烧伤创面愈合植物的化学成分、所用植物部位、用途及动物模型。
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引用次数: 11
Immunocosmeceuticals: An emerging trend in repairing human hair damage 免疫药妆:修复人类头发损伤的新兴趋势
Pub Date : 2013-07-01 DOI: 10.4103/2229-5186.115531
K. Selvan, Sentila Rajan, T. Suganya, G. Parameshwari, Michael Antonysamy
Hair is one of the most important portions for beauty care and in recent years grooming and cosmetic treatment of hair has drastically risen. Substantially, it may deteriorate and weaken the hair by modification of keratin protein. This makes the hair dry, brittle and split vend occurs due to loss of hair strength and the damage further increases with cosmetic treatments. The various poor ingredients are being used for repairing which have extremely poor compatibility with hair. Now the hair care products can be introduced with an active ingredient comprising a yolk derived anti-hair antibody immunoglobin obtained from egg of chickens immunized with damaged hair as antigen. This immuno-cosmeceuticals can repair the hair damage and imparts flexibility and smoothness to the hair. These effects are not lost by the ordinary shampooing. This article focuses on the characteristic of human hair, its damaging processes and the effects of immuno-cosmeceuticals for repairing the hair damage.
头发是美容护理中最重要的部分之一,近年来,对头发的修饰和美容治疗急剧增加。实质上,它会通过改变角蛋白而使头发变坏和变弱。这使得头发干燥、易碎和分叉,因为头发失去了力量,美容治疗进一步增加了损伤。各种劣质成分被用于修复,与头发的相容性极差。现在,护发产品可以引入一种活性成分,该活性成分包括蛋黄衍生的抗毛发抗体免疫球蛋白,该免疫球蛋白是从以受损毛发作为抗原免疫的鸡的鸡蛋中获得的。这种免疫药妆能修复头发损伤,使头发柔顺。这些效果不会因为普通的洗头而消失。本文主要介绍了人类头发的特性、头发的损伤过程以及免疫药妆对头发损伤的修复作用。
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引用次数: 2
Synthesis, characterization, and determination of metabolite of verapamil hydrochloride by reversed-phase high performance liquid chromatography 盐酸维拉帕米代谢物的合成、表征及反相高效液相色谱法测定
Pub Date : 2013-07-01 DOI: 10.4103/2229-5186.115558
P. Pathade, N. Bhatia, H. More, M. Bhatia, K. Ingale
Aims: A suitable reversed-phase high performance liquid chromatography (RP-HPLC) method for detection and determination of laboratory synthesized metabolite norverapamil (NVER) present in the pharmaceutical formulations is the prime purpose of this study. The present study deals with synthesis, characterization, and development of simple, selective, rapid, and sensitive RP-HPLC method for simultaneous determination of verapamil (VER) and its synthetic metabolite NVER. Materials and Methods: A HIQ sil ODS C-18 column having 250 mm × 4.6 mm i.d. in isocratic mode with a mobile phase consisting methanol: Water (70:30 v/v, pH adjusted to 7.4 with dilute orthophosphoric acid (OPA) and triethylamine used as an organic modifier to avoid tailing effect). The flow rate was 1.0 ml/min and effluents were monitored at 222 nm. Results: The retention time of synthesized metabolite NVER and its parent drug VER were found to be 3.44 and 5.67 min, respectively. Valsartan (VAL) was used as the internal standard. The limit of detection were found to be 0.30 μg/ml for VER and 1.21μg/ml for NVER from physical mixture, and limit of quantitation 1.06 μg/ml for VER and 4.14 μg/ml for NVER. Conclusions: The method can be used for quantitation of synthesized metabolite NVER, in presence of the parent drug VER which could be useful in detection and determination of some impurities, such as NVER, described in European Pharmacopeia and others which can be toxic and often present in the pharma ceutical formulations.
目的:建立一种合适的反相高效液相色谱法(RP-HPLC)检测和测定制剂中实验室合成代谢物诺维拉帕米(NVER)的主要目的。本文研究了维拉帕米(verapamil, VER)及其合成代谢物NVER的简便、选择性、快速、灵敏的反相高效液相色谱(RP-HPLC)方法的合成、表征和建立。材料和方法:250mm × 4.6 mm的HIQ sil ODS C-18色谱柱,等密度模式,流动相为甲醇:水(70:30 v/v, pH调至7.4,稀正磷酸(OPA)和三乙胺作为有机改性剂以避免尾效应)。流速为1.0 ml/min,在222 nm处监测流出物。结果:合成代谢物NVER的滞留时间为3.44 min,母药VER的滞留时间为5.67 min。缬沙坦(VAL)作为内标。物理混合物中VER的检出限为0.30 μg/ml, NVER的检出限为1.21μg/ml, VER的定量限为1.06 μg/ml, NVER的定量限为4.14 μg/ml。结论:该方法可用于在母体药物VER存在的情况下合成代谢物NVER的定量,可用于检测和测定某些杂质,如欧洲药典中描述的NVER和其他有毒的、经常出现在医药制剂中的杂质。
{"title":"Synthesis, characterization, and determination of metabolite of verapamil hydrochloride by reversed-phase high performance liquid chromatography","authors":"P. Pathade, N. Bhatia, H. More, M. Bhatia, K. Ingale","doi":"10.4103/2229-5186.115558","DOIUrl":"https://doi.org/10.4103/2229-5186.115558","url":null,"abstract":"Aims: A suitable reversed-phase high performance liquid chromatography (RP-HPLC) method for detection and determination of laboratory synthesized metabolite norverapamil (NVER) present in the pharmaceutical formulations is the prime purpose of this study. The present study deals with synthesis, characterization, and development of simple, selective, rapid, and sensitive RP-HPLC method for simultaneous determination of verapamil (VER) and its synthetic metabolite NVER. Materials and Methods: A HIQ sil ODS C-18 column having 250 mm × 4.6 mm i.d. in isocratic mode with a mobile phase consisting methanol: Water (70:30 v/v, pH adjusted to 7.4 with dilute orthophosphoric acid (OPA) and triethylamine used as an organic modifier to avoid tailing effect). The flow rate was 1.0 ml/min and effluents were monitored at 222 nm. Results: The retention time of synthesized metabolite NVER and its parent drug VER were found to be 3.44 and 5.67 min, respectively. Valsartan (VAL) was used as the internal standard. The limit of detection were found to be 0.30 μg/ml for VER and 1.21μg/ml for NVER from physical mixture, and limit of quantitation 1.06 μg/ml for VER and 4.14 μg/ml for NVER. Conclusions: The method can be used for quantitation of synthesized metabolite NVER, in presence of the parent drug VER which could be useful in detection and determination of some impurities, such as NVER, described in European Pharmacopeia and others which can be toxic and often present in the pharma ceutical formulations.","PeriodicalId":10187,"journal":{"name":"Chronicles of Young Scientists","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90843382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and validation of a reversed-phase HPLC method for simultaneous estimation of clotrimazole and beclomethasone dipropionate in lotion and cream dosage form 建立反相高效液相色谱法同时测定洗剂和乳膏剂型中氯霉唑和二丙酸倍氯米松的含量
Pub Date : 2013-07-01 DOI: 10.4103/2229-5186.115548
Komal Dhudashia, Amit V. Patel, C. Patel
Background: The combination of Clotrimazole and Beclomethasone dipropionate is used as anti-fungal and anti-inflammatory for external use in the form of cream and lotion. Aim: A simple, specific, economic, precise, and accurate reversed-phase high performance liquid chromatographic method development for the simultaneous estimation of clotrimazole (CT) and beclomethasone dipropionate (BD) in lotion and cream formulations. Materials and Methods: The chromatographic separation was achieved on a Kromasil C18 (150 mm × 4.6 mm, 5 μm) analytical column. A mixture of acetonitrile-water (70:30, v/v) was used as the mobile phase, at a flow rate of 1 ml/min and detector wavelength at 254 nm. The validation of the proposed method was carried out for specificity, linearity, accuracy, precision, limit of detection, limit of quantitation, and system suitability test as per ICH guideline. Results: The retention time of CT and BD was found to be 5.4 and 4 min, respectively. The linear dynamic ranges were from 2-16 μg/ml and 80-640 μg/ml for BD and CT, respectively. Limit of detection and quantification for BD were 0.039 and 0.12 μg/ml, for CT 1.24 and 3.77 μg/ml, respectively. Conclusions: The developed method was validated and found to be simple, specific, accurate and precise and can be used for routine quality control analysis of titled drugs in combination in lotion and cream formulation.
背景:氯曲霉唑与二丙酸倍氯米松联用作为抗真菌和抗炎的外用乳膏和洗剂。目的:建立一种简便、特异、经济、精确、准确的反相高效液相色谱法,用于同时测定洗剂和面霜制剂中氯霉唑(CT)和二丙酸倍氯米松(BD)的含量。材料与方法:色谱柱为Kromasil C18 (150 mm × 4.6 mm, 5 μm)。以乙腈-水(70:30,v/v)为流动相,流速为1 ml/min,检测器波长为254 nm。方法的特异性、线性度、准确度、精密度、检出限、定量限和系统适用性试验均按照ICH指南进行验证。结果:CT和BD的停留时间分别为5.4 min和4 min。BD和CT的线性动态范围分别为2 ~ 16 μg/ml和80 ~ 640 μg/ml。双酚d的检出限和定量限分别为0.039和0.12 μg/ml, CT为1.24和3.77 μg/ml。结论:所建立的方法简便、专属性强、准确度高、精密度好,可用于洗剂乳霜制剂中冠名药物联用的常规质量控制分析。
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引用次数: 8
Comparative study of the effect of taping on scapular stability and upper limb function in recovering hemiplegics with scapular weakness 肩胛骨无力偏瘫患者复健后,胶布对肩胛骨稳定性及上肢功能影响的比较研究
Pub Date : 2013-07-01 DOI: 10.4103/2229-5186.115551
Dhwanit S. Shah, Divakar Balusamy, M. Verma, Giri Jui
Background: Hemiplegia is the commonest form of paralysis, involving arm, leg and sometimes the face on one side of the body. Shoulder girdle in chronic hemiplegic suffers from two sorts of problems (a) spasticity of elevators and retractors, which pull the scapula into a fixed elevated and retracted position. (b) weakness of the opposite group of scapular muscles, i.e., depressors and protectors. This leads to instability of the scapulothoracic joint resulting in impaired functional use of the upper limb, taping is a method of maintaining orientation of the scapula by means of proprioceptive biofeedback to the patient. Aim of this study is to check the effect of taping on scapular stability and upper limb function in recovering hemiplegics. Objectives of the Study: (1) To study the effect of taping on functional performance of the hemiplegic upper extremity. (2) To compare the effect of taping combined with physiotherapeutic exercises v/s physiotherapeutic exercises alone on functional independence of the hemiplegic upper extremity. Subjects: All the 37 chronic hemiplegic patients with scapular weakness were taken and divided into two groups: Group A (Experimental group) and Group B (Control group). Materials and Methods: All the 37 chronic hemiplegic patients were evaluated by Fugl Meyer Physical Performance Assessment Scale for hemiplegic upper extremity before starting the treatment. Group A patients received scapular taping combined with physiotherapeutic exercises and Group B patients received only physiotherapeutic exercises for the period of 2 weeks. After 2 weeks both Group A and B patients were re-evaluated on Fugl Meyer Physical Performance Assessment Scale for hemiplegic upper extremity. Results: There was a significant improvement between the pre- and post-treatment scores of Group A patients on the Fugl Meyer Physical Performance Assessment Scale of hemiplegic upper extremity, whereas Group B patients score on the same scale was insignificant. Conclusion: Scapular taping has improved to be effective in improving stability of the scapula and also in improving functioning motor performance in hemiplegic upper extremities in recovering hemiplegic patients along with traditional physiotherapeutic exercises.
背景:偏瘫是最常见的麻痹形式,包括手臂、腿部,有时包括身体一侧的面部。慢性偏瘫患者的肩胛骨有两种问题:(1)肩胛骨的提牵肌痉挛,将肩胛骨拉至固定的抬高和收缩位置。(b)肩胛骨另一组肌肉无力,即抑制肌和保护肌。这导致肩胛骨关节不稳定,导致上肢功能使用受损。捆扎是一种通过向患者提供本体感觉生物反馈来维持肩胛骨定向的方法。本研究的目的是检查胶布对恢复偏瘫患者肩胛骨稳定性和上肢功能的影响。研究目的:(1)研究胶布对偏瘫上肢功能表现的影响。(2)比较贴敷联合物理治疗运动与单独物理治疗运动对偏瘫上肢功能独立性的影响。选取慢性偏瘫伴肩胛骨无力患者37例,分为A组(实验组)和B组(对照组)。材料与方法:37例慢性偏瘫患者治疗前均采用Fugl Meyer上肢偏瘫体能评定量表进行评定。A组患者采用肩胛骨贴敷联合理疗锻炼,B组患者仅采用理疗锻炼,疗程为2周。2周后,对A组和B组患者重新进行Fugl Meyer上肢偏瘫体能评定量表评估。结果:a组患者治疗前与治疗后在Fugl Meyer上肢肢体功能评定量表上的得分有显著性改善,而B组患者在同一量表上的得分无显著性改善。结论:肩胛骨贴带在偏瘫恢复期患者肩胛骨稳定性和上肢功能运动能力的改善上,与传统的物理治疗训练相结合,效果显著。
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引用次数: 5
Congenital melanocytic nevus of chin 先天性下巴黑素细胞痣
Pub Date : 2013-07-01 DOI: 10.4103/2229-5186.115560
D. Chauhan, Y. Guruprasad
{"title":"Congenital melanocytic nevus of chin","authors":"D. Chauhan, Y. Guruprasad","doi":"10.4103/2229-5186.115560","DOIUrl":"https://doi.org/10.4103/2229-5186.115560","url":null,"abstract":"","PeriodicalId":10187,"journal":{"name":"Chronicles of Young Scientists","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86372751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What is the gene definition now and what is next 现在基因的定义是什么,接下来又是什么
Pub Date : 2013-01-01 DOI: 10.4103/2229-5186.108811
Ashok K. Singh
{"title":"What is the gene definition now and what is next","authors":"Ashok K. Singh","doi":"10.4103/2229-5186.108811","DOIUrl":"https://doi.org/10.4103/2229-5186.108811","url":null,"abstract":"","PeriodicalId":10187,"journal":{"name":"Chronicles of Young Scientists","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79420036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
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Chronicles of Young Scientists
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