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The Assessment of Neurological Development of the Infants with Prenatal COVID-19 Exposure 产前新冠肺炎暴露婴儿神经发育的评估
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-01-10 DOI: 10.33808/clinexphealthsci.1102756
Senem Ayça, Semra Yüksel, Hatice Yaşat Nacar, Pınar Arıcan
Objective: The effects of prenatal coronavirus 2019 disease (COVID-19) exposure on the infantile neurological development are unknown. It has been considered that the inflammatory, thrombotic, and vascular changes occurred in the placentas taken from pregnant women diagnosed with COVID-19 and the inflammatory nature of COVID-19 infection may lead to negative obstetric and neurological events. We aimed to assess the potential neurological effects of prenatal COVID-19 exposure on the infant. Methods: The present study included 2–12-month-old infants born to women with positive real-time reverse transcription polymerase chain reaction test results for COVID-19 from the population of pregnant patients under routine follow-up. The neurological examinations and the Denver II Developmental Screening Test (DDST II) were performed for 41 infants aged 2–12 months to assess the neurological effects of prenatal COVID-19 exposure. Results: The average gestational age of the infants was 38.7 ± 1.9 weeks, and the average birth weight was 3198 ± 543 g. Eight of the infants had a history of hospitalization in the neonatal intensive care unit. The neurological examination and the neuromotor development of 40 (96%) infants were normal for their age group. Only one infant had abnormal neurological examination and DDST II result. Conclusion: The findings of the study suggest that prenatal COVID-19 exposure has no negative neurological impact on infants. Long-term prospective studies with larger sample sizes are needed for more comprehensive assessment of the neurological effects of prenatal COVID-19 exposure on the infants.
目的:产前接触2019冠状病毒病(新冠肺炎)对婴儿神经发育的影响尚不清楚。据认为,从诊断为新冠肺炎的孕妇身上取出的胎盘中发生的炎症、血栓和血管变化以及新冠肺炎感染的炎症性质可能会导致产科和神经系统的负面事件。我们旨在评估产前接触新冠肺炎对婴儿的潜在神经影响。方法:本研究纳入了常规随访的孕妇群体中新冠肺炎实时逆转录聚合酶链反应检测结果呈阳性的妇女所生的2至12个月大的婴儿。对41名2-12个月大的婴儿进行了神经系统检查和Denver II发育筛查试验(DDST II),以评估产前接触新冠肺炎对神经系统的影响。结果:这些婴儿的平均胎龄为38.7±1.9周,平均出生体重为3198±543g。其中8名婴儿有在新生儿重症监护室住院史。40名(96%)婴儿的神经系统检查和神经运动发育正常。只有一名婴儿的神经系统检查和DDST II结果异常。结论:研究结果表明,产前接触新冠肺炎对婴儿的神经系统没有负面影响。需要更大样本量的长期前瞻性研究,以更全面地评估产前新冠肺炎暴露对婴儿的神经影响。
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引用次数: 0
Evaluation of Nursing Care in the Early Postpartum Period 产后早期护理的评价
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2022-12-30 DOI: 10.33808/clinexphealthsci.891578
Seda Karaçay Yıkar, Ebru Gözüyeşil, E. Nazik, Ebru Var
Objective: Evaluation of the care given in the postpartum period is vital in terms of the quality of care. The aim of this study was to evaluate nursing care in the early postpartum period. Methods: This descriptive and cross-sectional study was conducted in a postpartum clinic between December 2016 and January 2017 with 130 mothers in postpartum period, and 18 nurses and midwives working in the same postpartum clinic. Data were collected using a personal information form, and the Postpartum Nursing Care Evaluation Tool (PPNCET). The data analysis was conducted using percentages, arithmetic mean, independent samples t-test, Mann-Whitney U test, and Kruskal-Wallis test. Results: The mean age of the mothers was 26.80 ± 4.90, and of the nurses and midwives was 35.83 ± 12.14. The mean PPNCET score of the mothers was 141.58 ± 32.03. The mean care subscale score of the mothers was 69.88 ± 12.06 and of the education subscale was 71.70 ± 19.97. The mean PPNCET score of the nurses and midwives was 153.50 ± 23.18. The mean care subscale score of the nurses and midwives was 73.38 ± 8.84, and the mean education subscale score was 80.11 ± 14.33. Conclusions: The mean PPNCET score of mothers and nurses and midwives were higher than the average. Higher PPNCET scores of the nurses and midwives compared to the mothers suggests that either the postpartum care given was not perceived as adequate by the mothers, or the care was not served in adequate quality. To increase postpartum care satisfaction of the mothers, involving nurses and midwives in the care process more is suggested. In line with these results, planning in-service training programs to develop the knowledge and skills of the nurses and midwives would be beneficial in increasing the quality of service
目的:评估产后护理对护理质量至关重要。本研究的目的是评估产后早期的护理。方法:这项描述性和横断面研究于2016年12月至2017年1月在一家产后诊所进行,对象为130名产后母亲,以及在同一产后诊所工作的18名护士和助产士。使用个人信息表和产后护理评估工具(PPNCET)收集数据。使用百分比、算术平均值、独立样本t检验、Mann-Whitney U检验和Kruskal-Wallis检验进行数据分析。结果:产妇平均年龄为26.80±4.90岁,护士和助产士平均年龄为35.83±12.14岁。母亲的PPNCET平均得分为141.58±32.03。母亲的护理分量表平均得分为69.88±12.06,教育分量表平均分为71.70±19.97。护士和助产士的PPNCET平均得分为153.50±23.18。护士和助产士的护理分量表平均得分为73.38±8.84,教育分量表平均分为80.11±14.33。结论:母亲、护士和助产士的PPNCET平均得分高于平均水平。与母亲相比,护士和助产士的PPNCET得分更高,这表明要么母亲认为产后护理不够充分,要么护理质量不够。为了提高产妇的产后护理满意度,建议护士和助产士更多地参与护理过程。根据这些结果,规划在职培训计划以发展护士和助产士的知识和技能将有助于提高服务质量
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引用次数: 0
Perceptions of Turkish Nursing Students on Nursing Diagnose 土耳其护生对护理诊断的认知
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2022-12-30 DOI: 10.33808/clinexphealthsci.951967
Münevver Sönmez, Öznur Gürlek Kısacık
Objective: This study aimed to determine how Turkish nursing students’ perceived nursing diagnosis.Methods: This descriptive and cross-sectional study was carried out with 655 nursing students in the Departments of Nursing in the Health Sciences Faculties of two universities, in the Aegean and western Black Sea Region, between 15 February and 5 April 2020. The Students Information Form and Perceptions of Nursing Diagnosis Scale were used for data collection. The independent samples t-test, one-way ANOVA test, and the Mann-Whitney U-test with Bonferroni-correction were used to determine the differences between the groups. Pearson correlation analysis was used to determine the effects of independent variablesResults: The mean age of the nursing students was 21.12±1.39; 76.6% of them were female and 36.8% were in the second-year. 53.7% of the nursing students reported that they had difficulty in making nursing diagnoses. The overall Perceptions of Nursing Diagnosis Survey score of the nursing students was found to be 2.46±051. Statistically significant difference was found between Perceptions of Nursing Diagnosis Survey scores in terms of gender (p=0.012), the necessity of nursing diagnosis (p<0.001), and having sufficient knowledge about nursing diagnosis (p=0.019).Conclusions: The findings of this study have revealed that Turkish nursing students’ perceptions of nursing diagnoses are positive. It is important that use effective teaching methods in teaching nursing diagnoses in fundamental nursing education, to give more importance to nursing diagnoses. It is recommended to plan qualitative studies to in-depth examine students’ perceptions with randomized controlled studies involving innovative educational interventions in the future
目的:本研究旨在了解土耳其护生感知护理诊断的情况。方法:在2020年2月15日至4月5日期间,对爱琴海和黑海西部地区两所大学健康科学学院护理系的655名护理专业学生进行了描述性和横断面研究。采用《学生信息表》和《护理诊断感知量表》进行数据收集。采用独立样本t检验、单因素方差分析检验和bonferroni校正的Mann-Whitney u检验确定组间差异。结果:护生的平均年龄为21.12±1.39岁;其中女生占76.6%,二年级占36.8%。53.7%的护生表示在护理诊断方面存在困难。护生护理诊断认知调查总分为2.46±051分。护理诊断认知调查得分在性别(p=0.012)、护理诊断必要性(p<0.001)、护理诊断知识知晓程度(p=0.019)方面差异有统计学意义。结论:本研究结果显示,土耳其护生对护理诊断的认知是积极的。在护理基础教育中,运用有效的教学方法进行护理诊断教学,提高对护理诊断的重视程度是十分重要的。建议在未来策划定性研究,以随机对照研究深入考察学生的认知,包括创新的教育干预措施
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引用次数: 0
Foot Muscle Strength, Muscle Shortness, Balance, and Shoe Preferences in Different Foot Postures 足部肌肉力量,肌肉短度,平衡和不同足部姿势的鞋子偏好
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2022-12-30 DOI: 10.33808/clinexphealthsci.714950
Banu Ünver, H. Taskiran, A. Akgöl
Objective: The aim of this study was to investigate the foot muscle strength, muscle shortness, tibialis posterior endurance, balance, and the shoe preference differences between the neutral and pronated foot posture. Methods: Forty-nine participants consisting of 23 women and 26 men, and age of between 18 and 45 years were participated in the study. Foot posture, medial longitudinal arch height, height, gastrocnemius and hamstring muscle shortness, foot and ankle muscle strength, tibialis posterior muscle endurance, static balance, and shoe preferences of the participants were evaluated. Subjects were recruited into two groups according to their foot posture evaluated with Foot Posture Index: as those with neutral and pronated foot posture. Results: Navicular drop, gastrocnemius, and hamstring muscle shortness were significantly higher in participants with pronated foot posture compared to those with neutral foot (p0.05). Conclusion: Flexibility of gastrocnemius and hamstring muscles were reduced, but foot muscle strength, tibialis posterior muscle endurance, and balance remained unaffected in young individuals with excessive foot pronation. Moreover, shoe preferences may not affect the foot posture in young people. Although all age-related biomechanical effects of foot pronation are not well known yet, muscle shortness seems to arise earlier than muscle weakness and reduced balance in pronated foot posture
目的:探讨中性足位和内翻足位对足部肌力、肌短、胫骨后耐力、平衡和鞋型偏好的影响。方法:研究对象49人,女性23人,男性26人,年龄在18 ~ 45岁之间。评估参与者的足位、内侧纵弓高度、身高、腓肠肌和腘绳肌短度、足部和踝关节肌肉力量、胫骨后肌耐力、静态平衡和鞋子偏好。根据受试者的足部姿势,用足部姿势指数进行评估,将受试者分为两组:中性足和内翻足。结果:与中性足姿势的参与者相比,前翻足姿势的参与者舟骨下垂、腓肠肌和腘绳肌短度显著增加(p0.05)。结论:年轻人过度内旋足时,腓肠肌和腘绳肌的柔韧性降低,但足部肌力、胫骨后肌耐力和平衡未受影响。此外,对鞋子的偏好可能不会影响年轻人的足部姿势。虽然所有与年龄相关的足内旋生物力学效应尚不清楚,但在足内旋姿势中,肌肉短促似乎比肌肉无力和平衡下降更早出现
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引用次数: 0
Electron microscopic GABA evaluation in hippocampal mossy terminals of genetic absence epilepsy rats receiving kindling stimulations 基因缺失型癫痫大鼠接受点燃刺激后海马苔藓末端GABA的电镜评价
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2022-12-30 DOI: 10.33808/clinexphealthsci.1030132
Nuray Nükhet İmdat, Ö. T. ÇİLİNGİR-KAYA, Zehra Nur Turgan Aşık, Tugba Karamahmutoglu, Medine Gülçebi İdriz Oğlu, D. Akakın, F. Onat, S. Şirvancı
Objective: The hypotheses related to the fact of epileptic mechanisms are mainly based on excitation-inhibition imbalance in central nervous system. GAERS (Genetic Absence Epilepsy Rats from Strasbourg) is a well-known animal model of absence epilepsy, and frequently used in experimental studies. In the present study, we aimed to examine possible morphological and gamma-aminobutyric acid (GABA) density changes in GAERS hippocampus after electrical kindling stimulations. Methods: All control and test group rats received 6 kindling stimulations. Rats were decapitated 1 h after the last stimulation. Ultrastructural GABA immunocytochemistry was used to evaluate GABA density quantitatively in mossy terminals of hippocampal CA3 region. Results: GABA levels were less in kindling groups compared to their controls, and in GAERS groups compared to Wistar groups; mitochondrial and dendritic spine area ratios were greater in GAERS groups compared to Wistar groups, although all these evaluations were statistically nonsignificant. Depletion of synaptic vesicles was evident in the mossy terminals of kindling groups. Conclusion: The reason of decreased levels of GABA found in the present study might be that GABA has been released from the synaptic pool rapidly at an early time period after the last stimulation, for compansation mechanisms. Depletion of synaptic vesicles observed in kindling groups shows that even 6 kindling stimulations have an impact of changing hippocampal morphology in trisynaptic cycle. The increased mitochondrial area in GAERS might be related to the increased mitochondrial activity. The increased dendritic spine area might be related to the increased performance of learning in GAERS. Our findings indicating that absence epilepsy and temporal lobe epilepsy have different mechanisms of epileptogenesis might be a basis for further experimental studies
目的:与癫痫机制有关的假说主要基于中枢神经系统兴奋抑制失衡。GAERS(来自斯特拉斯堡的遗传性失神癫痫大鼠)是一种著名的失神癫痫动物模型,经常用于实验研究。在本研究中,我们旨在检测电点燃刺激后GAERS海马可能的形态学和γ-氨基丁酸(GABA)密度变化。方法:对照组和试验组大鼠均接受6次点燃刺激。大鼠在最后一次刺激后1小时被斩首。采用超微结构GABA免疫细胞化学方法定量评价海马CA3区苔藓终末GABA密度。结果:点燃组GABA水平低于对照组,GAERS组低于Wistar组;与Wistar组相比,GAERS组的线粒体和树突棘面积比率更大,尽管所有这些评估在统计学上都不显著。在点燃组苔藓状的末端,突触小泡的消耗是明显的。结论:本研究中发现的GABA水平下降的原因可能是GABA在最后一次刺激后的早期迅速从突触池中释放,这是一种补偿机制。在点燃组中观察到的突触小泡的耗竭表明,即使是6次点燃刺激也会对三突触周期中海马形态的变化产生影响。GAERS中线粒体面积的增加可能与线粒体活性的增加有关。树突棘面积的增加可能与GAERS中学习成绩的提高有关。我们的研究结果表明,缺席性癫痫和颞叶癫痫具有不同的癫痫发生机制,这可能是进一步实验研究的基础
{"title":"Electron microscopic GABA evaluation in hippocampal mossy terminals of genetic absence epilepsy rats receiving kindling stimulations","authors":"Nuray Nükhet İmdat, Ö. T. ÇİLİNGİR-KAYA, Zehra Nur Turgan Aşık, Tugba Karamahmutoglu, Medine Gülçebi İdriz Oğlu, D. Akakın, F. Onat, S. Şirvancı","doi":"10.33808/clinexphealthsci.1030132","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1030132","url":null,"abstract":"Objective: The hypotheses related to the fact of epileptic mechanisms are mainly based on excitation-inhibition imbalance in central nervous system. GAERS (Genetic Absence Epilepsy Rats from Strasbourg) is a well-known animal model of absence epilepsy, and frequently used in experimental studies. In the present study, we aimed to examine possible morphological and gamma-aminobutyric acid (GABA) density changes in GAERS hippocampus after electrical kindling stimulations. \u0000Methods: All control and test group rats received 6 kindling stimulations. Rats were decapitated 1 h after the last stimulation. Ultrastructural GABA immunocytochemistry was used to evaluate GABA density quantitatively in mossy terminals of hippocampal CA3 region. \u0000Results: GABA levels were less in kindling groups compared to their controls, and in GAERS groups compared to Wistar groups; mitochondrial and dendritic spine area ratios were greater in GAERS groups compared to Wistar groups, although all these evaluations were statistically nonsignificant. Depletion of synaptic vesicles was evident in the mossy terminals of kindling groups. \u0000Conclusion: The reason of decreased levels of GABA found in the present study might be that GABA has been released from the synaptic pool rapidly at an early time period after the last stimulation, for compansation mechanisms. Depletion of synaptic vesicles observed in kindling groups shows that even 6 kindling stimulations have an impact of changing hippocampal morphology in trisynaptic cycle. The increased mitochondrial area in GAERS might be related to the increased mitochondrial activity. The increased dendritic spine area might be related to the increased performance of learning in GAERS. Our findings indicating that absence epilepsy and temporal lobe epilepsy have different mechanisms of epileptogenesis might be a basis for further experimental studies","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43730630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of p-Coumaric Acid on Reproductive and Remote Organ Damages Created by Adnexal Torsion/Detorsion: Biochemical and Immunohistochemical A Study 对香豆酸对附件扭转/扭转造成的生殖和远端器官损伤的作用:生化和免疫组织化学研究
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2022-12-30 DOI: 10.33808/clinexphealthsci.1036428
A. Tanyeli̇, F. N. Ekinci Akdemir, E. Eraslan, M. Güler, Tuncer Nacar, S. Çomaklı, I. Gülçin
Objective: We planned to search the effects of p-coumaric acid on ovary and lung injuries formed via bilateral adnexal torsion detorsion (T/D) in experimental rat model.Methods: 24 female, Sprague-Dawley rats were sorted out as 3 groups. Design of the groups was performed as sham (group I) and T/D (group II), p-coumaric acid+T/D (group III) groups. Sham group; abdomen area was applied incision and repaired with no T/D model application. T/D group; 3 h of torsion phase completed and then 3 h of detorsion stage was established. P-coumaric acid+T/D group; p-coumaric acid was administered at the dose of 100 mg/kg for 15 days by oral gavage and then, T/D model was performed. Following detorsion phase, rats were sacrificed, lung and ovarian tissues were excised for biochemical and immunohistochemical evaluations. Results: When it is compared to group I, oxidant parameters elevated significantly in group II (p<0.05) while the activity of antioxidant enzymes and TAS level decreased. On the other side, antioxidant enzyme activity raised and oxidant parameter levels diminished in group III compared to group II (p<0.05). Moreover, NF-kB, caspase 3 and LC3B protein expression levels increased in ovary and lung tissues of the group II. But NF-kB, caspase 3 and LC3B protein expression levels decreased in group III. Conclusion: As a consequence, p-coumaric acid acted a protective performance against ovary and lung injuries arising from adnexal T/D model in rats.
目的:探讨对香豆酸对实验性大鼠双侧附件扭转扭转(T/D)所致卵巢和肺损伤的影响。方法:选取雌性sd大鼠24只,分为3组。各组设计为假手术组(I组)、T/D组(II组)、对香豆酸+T/D组(III组)。虚假的集团;腹部区域应用切口修复,不应用T/D模型。T / D组;完成3 h的扭转阶段,然后建立3 h的扭转阶段。p -香豆酸+T/D组;对香豆酸按100 mg/kg剂量灌胃15 D,建立T/D模型。腐化期结束后,处死大鼠,切除肺和卵巢组织进行生化和免疫组化评价。结果:与ⅰ组比较,ⅱ组抗氧化指标显著升高(p<0.05),抗氧化酶活性和TAS水平下降。另一方面,与II组相比,III组抗氧化酶活性升高,氧化参数水平降低(p<0.05)。II组卵巢和肺组织NF-kB、caspase 3和LC3B蛋白表达水平升高。III组NF-kB、caspase 3和LC3B蛋白表达水平下降。结论:对香豆酸对附件T/D模型大鼠卵巢和肺损伤具有保护作用。
{"title":"The Role of p-Coumaric Acid on Reproductive and Remote Organ Damages Created by Adnexal Torsion/Detorsion: Biochemical and Immunohistochemical A Study","authors":"A. Tanyeli̇, F. N. Ekinci Akdemir, E. Eraslan, M. Güler, Tuncer Nacar, S. Çomaklı, I. Gülçin","doi":"10.33808/clinexphealthsci.1036428","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1036428","url":null,"abstract":"Objective: We planned to search the effects of p-coumaric acid on ovary and lung injuries formed via bilateral adnexal torsion detorsion (T/D) in experimental rat model.\u0000Methods: 24 female, Sprague-Dawley rats were sorted out as 3 groups. Design of the groups was performed as sham (group I) and T/D (group II), p-coumaric acid+T/D (group III) groups. Sham group; abdomen area was applied incision and repaired with no T/D model application. T/D group; 3 h of torsion phase completed and then 3 h of detorsion stage was established. P-coumaric acid+T/D group; p-coumaric acid was administered at the dose of 100 mg/kg for 15 days by oral gavage and then, T/D model was performed. Following detorsion phase, rats were sacrificed, lung and ovarian tissues were excised for biochemical and immunohistochemical evaluations. \u0000Results: When it is compared to group I, oxidant parameters elevated significantly in group II (p<0.05) while the activity of antioxidant enzymes and TAS level decreased. On the other side, antioxidant enzyme activity raised and oxidant parameter levels diminished in group III compared to group II (p<0.05). Moreover, NF-kB, caspase 3 and LC3B protein expression levels increased in ovary and lung tissues of the group II. But NF-kB, caspase 3 and LC3B protein expression levels decreased in group III. \u0000Conclusion: As a consequence, p-coumaric acid acted a protective performance against ovary and lung injuries arising from adnexal T/D model in rats.","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45578788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Effects of Heat and Massage Applications to the Lumbosacral Area on Duration of Delivery and Perception of Labor Pain: A Randomized Controlled Experimental Trial 腰骶区加热和按摩对分娩持续时间和分娩疼痛感知的影响:一项随机对照实验试验
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2022-12-30 DOI: 10.33808/clinexphealthsci.1025304
Ayşenur Durmuş, Gülşen Eryilmaz
Objective: This study was carried out to determine the effects of massage and hot-pack applications in the first stage of labor on perceptions of labor pain and duration of delivery. Methods: This randomized controlled experimental trial was conducted in an obstetrics and pediatrics hospital. The research sample comprised 120 pregnant women, 40 of whom were in the massage group, 40 of whom were in the hot-pack application group, and 40 of whom were in the control group. Patient identification forms, labor process monitoring forms, and a visual analogue scale (VAS) were used to collect data. Results: It was determined that the massage and hot-pack applications shortened the durations of the active and transition phases of labor. The massage and hot-pack applications also reduced perceptions of pain in the active and transition phases. Mean VAS scores of the massage and hot-pack application groups were lower than those of the control group (p
目的:本研究旨在探讨分娩第一阶段按摩和热敷对分娩疼痛感知和分娩持续时间的影响。方法:在某妇产科医院进行随机对照试验。研究样本包括120名孕妇,其中40人在按摩组,40人在热敷组,40人在对照组。使用患者识别表、分娩过程监测表和视觉模拟量表(VAS)收集数据。结果:按摩和热敷均能缩短产妇产程的活跃期和过渡期。按摩和热敷应用也减少了在活动和过渡阶段的疼痛感。按摩组和热敷组VAS平均评分均低于对照组(p
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引用次数: 0
The Effect of Duration of Active Labor Phase on Postpartum Fatigue and Comfort 主动产程持续时间对产后疲劳和舒适度的影响
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2022-12-30 DOI: 10.33808/clinexphealthsci.929352
Nuray Göker, Zümrüt Bilgin
Objective: This study aims to examine the effect of the duration of the active labor phase on postpartum fatigue and comfort.Methods: This descriptive study was conducted in a maternity hospital in Istanbul, Turkey date 2018. Nulliparous pregnant women without any risk (n: 120) participated in the study. Data were collected using the “Information Form”, the “Visual Analogue Scale”, the “Postpartum Comfort Scale” and the “Visual Analogue Scale for Fatigue”, and statistically analyzed.Results: The mean age of the women was 23.66±4.24 years. 22.5% felt very tired in the postpartum period. Their mean duration of active labor phase was 5.00±1.88 hours. Their Postpartum Comfort Scale and Visual Analogue Scale for Fatigue mean scores were 131.30±13.39 and 96.67±47.82, respectively.Conclusion: Duration of active labor phase did not affect postpartum fatigue and comfort of women
目的:本研究旨在检验积极产程持续时间对产后疲劳和舒适度的影响。方法:这项描述性研究于2018年在土耳其伊斯坦布尔的一家妇产医院进行。没有任何风险的孕妇(120名)参与了这项研究。使用“信息表格”、“视觉模拟量表”、“产后舒适度量表”和“疲劳视觉模拟量量表”收集数据,并进行统计分析。结果:女性平均年龄为23.66±4.24岁。22.5%的人在产后感到非常疲倦。她们的活动产程平均持续时间为5.00±1.88小时。产后舒适度量表和疲劳视觉模拟量表的平均得分分别为131.30±13.39和96.67±47.82。结论:积极产程持续时间不影响产妇产后疲劳和舒适度
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引用次数: 0
A prospective study concerning the effect of pharmaceutical care services on patients with heart failure 药物护理服务对心力衰竭患者影响的前瞻性研究
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2022-12-30 DOI: 10.33808/clinexphealthsci.895693
N. Taner, B. Berk
Objective: Heart failure (HF), caused by an abnormality in cardiac function, is the inability of heart tissue to pump blood or deliver sufficient oxygen, resulting in abnormal diastolic volume. Drug-Related Problems (DRPs) can cause significant but preventable morbidity and mortality once specific medication errors and their contributing factors are identified. The aim of this prospective study is to determine the effect of pharmaceutical care in patients with heart failure in a Turkish hospital. Methods: A total of 160 patients with heart failure (80 patients in the control group, 80 patients in the intervention group) were examined at a university hospital. The results of the Pharmaceutical Care Survey were evaluated in accordance with the objective of the study. In addition, using the Pharmaceutical Care Network Europe (PCNE) classification system V8.01, the role and importance of the clinical pharmacist in identifying, preventing and resolving drug-related problems encountered during the treatment of two groups was assessed. The number and causes of potential DRPs were taken into scrutiny. Results: Comparing the results of the Pharmaceutical Care Survey in both groups at the end of the 6th month, the study group shows a significant improvement in the rates of “forgetting to take medication” (2.9%) and “experiencing any side effects from your drug” (4.5%). Compared to other problems, ineffectiveness of the drugs used in treatment was reported as the most common drug-related problem (n=23; 28.7%) in the study group (p
目的:心力衰竭(HF)是由心脏功能异常引起的,是指心脏组织无法泵血或输送足够的氧气,导致舒张容积异常。一旦确定了特定的药物错误及其促成因素,药物相关问题(DRP)可能会导致显著但可预防的发病率和死亡率。这项前瞻性研究的目的是确定土耳其一家医院对心力衰竭患者的药物治疗效果。方法:在某大学医院对160例心力衰竭患者(对照组80例,干预组80例)进行检查。药物护理调查的结果根据研究目的进行了评估。此外,使用欧洲药物护理网络(PCNE)分类系统V8.01,评估了临床药剂师在识别、预防和解决两组患者治疗过程中遇到的药物相关问题方面的作用和重要性。对潜在DRP的数量和原因进行了仔细审查。结果:比较两组在第6个月底的药物护理调查结果,研究组的“忘记服药”率(2.9%)和“药物有任何副作用”率(4.5%)有显著改善。与其他问题相比,据报道,治疗中使用的药物无效是研究组最常见的药物相关问题(n=23;28.7%)(p
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引用次数: 0
NF-қB and COX-2 Relation Between Endometrial Cancer and the Clinicopathological Parameters NF-қB和COX-2与子宫内膜癌临床病理参数的关系
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2022-12-30 DOI: 10.33808/clinexphealthsci.1049382
A. Iyibozkurt, B. Çakmakoğlu, Baris Ertugrul, E. Iplik
Objective: Our study examines nuclear factor kappa B (NF-қB) and cyclooxygenase-2 (COX-2) polymorphisms in the most common gynecological cancer type, endometrial cancer, and the relationship between disease parameters and these polymorphisms. Methods: In our patient group; while 109 endometrial cancer patients were examined and treated in the Department of Gynecology and Obstetrics, Istanbul Medical Faculty, and 106 healthy women without the disease were included in the control group. DNA of blood samples taken from all groups were isolated; COX-2 765C> G and COX-2 1195A> G polymorphisms were studied with NF-қB-94 ins / delATTG. Genotypes analyzed using the PCR-based restriction fragment length polymorphisms (RFLP) method were investigated in terms of the relationship between endometrial cancer susceptibility and endometrial cancer disease parameters. Results in SPSS 17 program; Student’s t-tests were analyzed using Anova, Fisher’s exact, and Chi-square tests. Results: NF-қB D + and DD genotype, COX-2 765 G + and GG genotype, and COX-2 1195 AA genotype were found to be significantly more common in the endometrial cancer group compared to the control group (p
目的:探讨核因子κ B (NF-қB)和环氧化酶-2 (COX-2)在妇科最常见的癌症类型子宫内膜癌中的多态性及其与疾病参数的关系。方法:在本组患者中;109名子宫内膜癌患者在伊斯坦布尔医学院妇产科接受检查和治疗,106名未患病的健康妇女作为对照组。分离各组血液样本的DNA;利用NF-қB-94 ins / delATTG研究COX-2 765C> G和COX-2 1195A> G多态性。利用基于pcr的限制性片段长度多态性(RFLP)方法分析基因型,探讨子宫内膜癌易感性与子宫内膜癌疾病参数的关系。SPSS 17程序结果;学生t检验采用方差分析、费雪精确检验和卡方检验进行分析。结果:NF-қB D +和DD基因型、cox - 2765 G +和GG基因型、cox - 21195 AA基因型在子宫内膜癌组的发生率明显高于对照组(p
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Clinical and Experimental Health Sciences
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