Clinical and Experimental Dental Research最新文献_第6页

Stainability of Polished and Glazed Printed Monolithic Zirconia After Coffee Thermocycling 咖啡热循环后抛光和釉面印刷单片氧化锆的染色性能。

IF 2.2 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research

Pub Date : 2025-11-01 DOI: 10.1002/cre2.70246

Soraya Soleimani, Elaheh Beyabanaki, Kiana Shakeri, Reza Eftekhar Ashtiani, Farhad Tabatabaian

Objective

This study assessed the impact of the method of manufacturing, surface treatment, and thickness on the stainability of zirconia after thermocycling.

Methods

Twenty 0.5 × 10 mm and 20 1 × 10 mm zirconia disks were fabricated using a milling machine. Also, 20 0.5 × 10 mm and 20 1 × 10 mm zirconia disks were fabricated using a 3D printer. After sintering, samples were subjected to one of the two surface treatments (n = 10). Eight study groups were arranged as (1) 0.5 mm printed–polished, (2) 1 mm printed–polished, (3) 0.5 mm printed–glazed, (4) 1 mm printed–glazed, (5) 0.5 mm milled–polished, (6) 1 mm milled–polished, (7) 0.5 mm milled–glazed, and (8) 1 mm milled–glazed. CIELab values were measured with a spectrophotometer before and after 10,000 thermal cycles in coffee solution. ΔE₀₀ readings were compared with perceptibility (< 0.8) and acceptability (< 1.8) thresholds. Data were analyzed using three-way ANOVA and the Games–Howell test (α = 0.05).

Results

Although all mean ΔE₀₀ values were below the acceptability threshold, only 1 mm printed–glazed zirconia and all milled zirconia samples, except for the 0.5 mm polished group, were below the perceptibility threshold. A significant interaction was found between the production method, surface treatment, and thickness (p = 0.002); 0.5 mm printed zirconia, either polished or glazed, and also 1 mm polished printed zirconia exhibited significantly higher ΔE₀₀ than their milled counterparts. Moreover, glazing significantly reduced stainability in all zirconia specimens (p < 0.05). Also, 1 mm milled–polished zirconia had a lower ΔE₀₀ value than its 0.5 mm counterpart (p = 0.038).

Conclusions

Printed zirconia had less color stability than milled zirconia. Glazing provided the lower color change for both milled and printed zirconia. Thicker milled–polished zirconia had a better color stability.

Clinical Significance

Although the color stainability of printed zirconia was more than milled zirconia, it showed clinically acceptable color change values along with the milled zirconia, regardless of the method of surface treatment and thickness.

目的：研究制备方法、表面处理和厚度对氧化锆热循环后可染性的影响。方法：采用铣床制备20个0.5 × 10 mm和20个1 × 10 mm氧化锆圆盘。利用3D打印机制备了20个0.5 × 10 mm和20个1 × 10 mm的氧化锆圆盘。烧结后，样品进行两种表面处理中的一种（n = 10）。八个研究组被安排为(1)0.5 mm印刷抛光，(2)1mm印刷抛光，(3)0.5 mm印刷抛光，(4)1mm印刷抛光，(5)0.5 mm研磨抛光，(6)1mm研磨抛光，(7)0.5 mm研磨抛光，(8)1mm研磨抛光。CIELab值在咖啡溶液中10000次热循环前后用分光光度计测量。将ΔE00读数与可感知性进行比较(结果：虽然所有的ΔE00平均值都低于可接受阈值，但除了0.5 mm抛光组外，只有1 mm印刷釉面氧化锆和所有研磨氧化锆样品低于可感知阈值。生产方法、表面处理和厚度之间存在显著的交互作用（p = 0.002）；0.5 mm的印刷氧化锆，无论是抛光的还是上釉的，以及1 mm抛光的印刷氧化锆，其表现都明显高于ΔE00。此外，上釉显著降低了所有氧化锆标本的染色性（p值为00），比0.5 mm的样品（p = 0.038）。结论：印刷氧化锆的颜色稳定性低于研磨氧化锆。上釉为研磨和印刷氧化锆提供了较低的颜色变化。粗磨抛光氧化锆的颜色稳定性较好。临床意义：虽然印刷氧化锆的颜色染色性高于研磨氧化锆，但无论表面处理方法和厚度如何，印刷氧化锆随研磨氧化锆呈现临床可接受的颜色变化值。

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引用次数: 0

Clustering of Oral Health-Related Behaviors and Their Association With Sociodemographic Factors in Adolescents Living in England, Wales, and Northern Ireland 英格兰、威尔士和北爱尔兰青少年口腔健康相关行为的聚类及其与社会人口因素的关联

IF 2.2 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research

Pub Date : 2025-10-30 DOI: 10.1002/cre2.70209

Ávila-Oliver Camila, Renato Venturelli, Dominga Ladevig, Tsakos Georgios, Watt Richard G

Objectives

This study investigated the clustering patterns of oral health-related behaviors and their relationship with sociodemographic factors in a national sample of 12- and 15-year-olds from England, Wales, and Northern Ireland.

Material and Methods

Data from the Child Dental Health Survey (CDHS) 2013 were analyzed. Five individual behaviors were considered: smoking, alcohol use, tooth brushing frequency, sugar intake, and dental attendance. Explanatory variables included sex, age, and eligibility for free school meal (FSM) (as a marker of socioeconomic deprivation). Clustering patterns were assessed using counted clusters, pairwise correlation, and observed/expected ratio analysis. Logistic regression models were performed to assess the associations between behavioral clusters and sociodemographic factors.

Results

The study included 4932 young people, with 51.5% aged 15 years, 50.6% male, and 17.4% eligible for FSM. Statistical differences were found in individual behaviors: Males were more likely to report lower tooth brushing frequency (28.1% vs. 13.6% for females), while 15-year-olds were more likely to engage in smoking (28.0% vs. 6.0%) and alcohol consumption (73.5% vs. 29.2%) compared to 12-year-olds. FSM-eligible adolescents were more likely to engage in all risk behaviors, except for alcohol consumption. Seven significant behavioral clusters were identified through O/E analysis, each involving combinations of two or three risk behaviors. In the regression analysis, age was strongly associated with these clusters. For example, 15-year-olds had significantly higher odds (OR: 7.04; 95% CI: 4.85–10.22) of exhibiting the cluster involving smoking and alcohol use compared to 12-year-olds. Sex and FSM eligibility also showed significant, though weaker, associations with five of the identified behavioral patterns.

Conclusions

Detrimental oral health behavioral clusters were more commonly observed among males, 15-year-olds, and adolescents from less advantaged backgrounds.

目的：本研究调查了来自英格兰、威尔士和北爱尔兰的12- 15岁青少年口腔健康相关行为的聚类模式及其与社会人口因素的关系。材料和方法：对2013年儿童口腔健康调查（CDHS）的数据进行分析。研究人员考虑了五种个人行为：吸烟、饮酒、刷牙频率、摄入糖和看牙医。解释变量包括性别、年龄和免费校餐（FSM）的资格（作为社会经济剥夺的标志）。使用计数聚类、两两相关和观察/期望比分析来评估聚类模式。采用Logistic回归模型评估行为聚类与社会人口因素之间的关系。结果：该研究纳入4932名年轻人，其中51.5%为15岁，50.6%为男性，17.4%符合FSM条件。个体行为存在统计学差异：男性更有可能报告较低的刷牙频率（28.1%对13.6%），而15岁的人更有可能吸烟（28.0%对6.0%）和饮酒（73.5%对29.2%）与12岁的人相比。符合fsm条件的青少年更有可能从事所有危险行为，除了饮酒。通过O/E分析确定了七个显著的行为集群，每个集群涉及两种或三种风险行为的组合。在回归分析中，年龄与这些聚类密切相关。例如，与12岁的孩子相比，15岁的孩子表现出吸烟和饮酒相关的群集的几率（OR: 7.04; 95% CI: 4.85-10.22）要高得多。性别和FSM资格也显示出显著的，尽管较弱的，与五种已确定的行为模式的关联。结论：不良口腔健康行为群在男性、15岁青少年和背景较差的青少年中更为常见。

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引用次数: 0

The Impact of Antioxidant Adjuncts on Periodontal Health in Type 2 Diabetes Patients: A Meta-Analysis 抗氧化辅助剂对2型糖尿病患者牙周健康的影响：一项meta分析

IF 2.2 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research

Pub Date : 2025-10-29 DOI: 10.1002/cre2.70215

Sara A. Abdulla, Bushra A. Abdalla, Aisha Ali Muhammed, Hayam A. Elawamy, Salima M. Hawda, Najah Mohamed, Enass H. Abduallah, Mustafa Y. G. Younis, Hajir Omar Alsanfaz, Hiba Abdelmunim Suliman

Background

The bidirectional relationship between periodontitis and type 2 diabetes (T2D) underscores the need for adjunctive therapies to enhance nonsurgical periodontal therapy (NSPT). This meta-analysis evaluates the efficacy of antioxidants in improving periodontal and glycemic outcomes in T2D patients with periodontitis.

Material and Methods

A systematic literature search was conducted using PubMed, Embase, Scopus, Web of Science, and Google Scholar, covering publications from 2015 to 2025. Antioxidants tested were melatonin, propolis, lycopene, ginger, vitamin C, omega-3 fatty acids (O3FAs), and grape seed extract. Outcomes (clinical attachment level [CAL], probing depth [PD], gingival index [GI], HbA1c) were analyzed using random-effects models (mean differences, 95% CIs). Risk of bias was assessed via the Cochrane criteria.

Results

Eight randomized controlled trials (RCTs, n = 315) were identified. Adjunctive antioxidants significantly improved CAL (melatonin: SMD −2.28, 95% CI −3.01 to −1.56; propolis: SMD −3.83, −4.79 to −2.87) and PD (melatonin: SMD −2.40, −3.14 to −1.66; propolis: SMD −1.78, −2.44 to −1.11). Melatonin and propolis also reduced HbA1c (melatonin: SMD −2.28; propolis: SMD −3.83). Lycopene and ginger showed modest effects, while vitamin C and O3FAs had minimal impact. Evidence certainty was moderate for CAL/HbA1c and low for PD/GI.

Conclusion

Antioxidants, particularly melatonin and propolis, enhance periodontal and glycemic outcomes in T2D-periodontitis patients. Despite promising results, limitations include small sample sizes and heterogeneity. Larger RCTs are needed to optimize protocols.

背景：牙周炎和2型糖尿病（T2D）之间的双向关系强调了辅助治疗的必要性，以加强非手术牙周治疗（NSPT）。本荟萃分析评估了抗氧化剂在改善伴有牙周炎的糖尿病患者牙周和血糖结局方面的疗效。材料与方法：系统检索PubMed、Embase、Scopus、Web of Science、谷歌Scholar等文献，检索时间为2015 - 2025年。测试的抗氧化剂包括褪黑素、蜂胶、番茄红素、生姜、维生素C、欧米伽-3脂肪酸（O3FAs）和葡萄籽提取物。采用随机效应模型分析结果（临床依恋水平（CAL）、探诊深度（PD）、牙龈指数（GI）、糖化血红蛋白（HbA1c））（平均差异95% ci）。通过Cochrane标准评估偏倚风险。结果：共纳入8项随机对照试验（rct, n = 315）。辅助抗氧化剂显著改善了CAL（褪黑素：SMD -2.28, 95% CI为-3.01至-1.56；蜂胶：SMD -3.83, -4.79至-2.87）和PD（褪黑素：SMD -2.40, -3.14至-1.66；蜂胶：SMD -1.78, -2.44至-1.11）。褪黑素和蜂胶也能降低HbA1c（褪黑素：SMD -2.28；蜂胶：SMD -3.83）。番茄红素和生姜的影响不大，而维生素C和O3FAs的影响最小。证据确定性为CAL/HbA1c为中等，PD/GI为低。结论：抗氧化剂，特别是褪黑素和蜂胶，可改善t2dm牙周炎患者的牙周和血糖结局。尽管结果很有希望，但局限性包括样本量小和异质性。需要更大的随机对照试验来优化方案。

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引用次数: 0

Investigation of Discoloration of Anterior Teeth With Three Types of Substances Used in Endodontic Treatment 牙髓治疗中三种物质对前牙变色的影响。

IF 2.2 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research

Pub Date : 2025-10-29 DOI: 10.1002/cre2.70204

Sahar Soltani, Eshagh Ali Saberi, Nazanin Shahradnia, Pedram Abdollahzade Sangrodi, Elham Majidi

Objective

This study aims to investigate the discoloration of anterior teeth with three types of substances used in endodontic treatment.

Materials and Methods

In this laboratory study, 75 newly extracted human anterior (central and lateral) teeth with full roots were examined. This study utilized the following materials: AH26, MTA Base (Maruchi), a novel formulation containing nano-zinc particles, and a second novel formulation containing both nano-zinc and nano-copper particles. The teeth in the first three groups were dried with paper points, and the canals were completely sealed using the sealer lateral filling technique with gutta-percha. Then the color of the samples was measured by a spectrophotometer at four times: initially, immediately after filling (0), 14 days, and 28 days later.

Results

The results showed that the mean color change (∆E) at all times (immediately, 14 days later, and 28 days later) was statistically significant between all groups (p < 0.05). The degree of color change decreased in the following order: AH26 > Zn-nano > Zn.Cu-nano > novel nano-zinc/copper material > MTA Base (Maruchi) > control group.

Conclusion

The results of the present study showed that sealers with a zinc base (Zn-nano and Zn.Cu-nanoparticles) had an appropriate color change. Therefore, they can be used alongside other sealers available in the market.

目的：研究三种牙髓治疗材料对前牙变色的影响。材料与方法：对75颗新拔除的全根人前牙（中央和外侧）进行了检查。本研究使用了以下材料：AH26， MTA碱（Maruchi），一种含有纳米锌颗粒的新型配方，以及第二种含有纳米锌和纳米铜颗粒的新型配方。前三组用纸点干燥牙齿，用杜胶侧边充填技术完全封闭根管。然后用分光光度计分四次测量样品的颜色：最初、填充后立即(0)、14天和28天后。结果：结果显示，各时刻（即刻、14 d后、28 d后）各组间平均颜色变化（∆E）均有统计学意义（p Zn-nano > Zn）。铜纳米>新型纳米锌/铜材料> MTA碱（丸内）>对照组。结论：本研究结果表明，锌基（纳米锌和纳米锌）的密封效果较好。铜纳米粒子)有适当的颜色变化。因此，它们可以与市场上的其他密封剂一起使用。

{"title":"Investigation of Discoloration of Anterior Teeth With Three Types of Substances Used in Endodontic Treatment","authors":"Sahar Soltani, Eshagh Ali Saberi, Nazanin Shahradnia, Pedram Abdollahzade Sangrodi, Elham Majidi","doi":"10.1002/cre2.70204","DOIUrl":"10.1002/cre2.70204","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aims to investigate the discoloration of anterior teeth with three types of substances used in endodontic treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>In this laboratory study, 75 newly extracted human anterior (central and lateral) teeth with full roots were examined. This study utilized the following materials: AH26, MTA Base (Maruchi), a novel formulation containing nano-zinc particles, and a second novel formulation containing both nano-zinc and nano-copper particles. The teeth in the first three groups were dried with paper points, and the canals were completely sealed using the sealer lateral filling technique with gutta-percha. Then the color of the samples was measured by a spectrophotometer at four times: initially, immediately after filling (0), 14 days, and 28 days later.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results showed that the mean color change (∆E) at all times (immediately, 14 days later, and 28 days later) was statistically significant between all groups (<i>p</i> < 0.05). The degree of color change decreased in the following order: AH26 > Zn-nano > Zn.Cu-nano > novel nano-zinc/copper material > MTA Base (Maruchi) > control group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The results of the present study showed that sealers with a zinc base (Zn-nano and Zn.Cu-nanoparticles) had an appropriate color change. Therefore, they can be used alongside other sealers available in the market.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70204","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145387620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preventive and Therapeutic Effects of Plant-Derived Compounds on Tooth Erosion: A Systematic Review and Meta-Analysis of In Situ and In Vitro Studies 植物源化合物对牙齿侵蚀的预防和治疗作用：原位和体外研究的系统回顾和荟萃分析。

IF 2.2 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research

Pub Date : 2025-10-28 DOI: 10.1002/cre2.70235

Mahtab Memarpour, Neda Afzali Baghdadabadi, Golnoush Farzinnia, Mahya Agharokh, Niloofar Mokhtari, Erfan Bardideh

Objectives

Tooth erosion is the nonbacterial and irreversible pathological dissolution of enamel and dentin, and is primarily influenced by lifestyle. This systematic review and meta-analysis aimed to evaluate the preventive and therapeutic effects of plant-derived compounds on tooth erosion using evidence from in vitro and in situ studies.

Materials and Methods

The review was registered in PROSPERO (CRD42023493906) and search was performed in PubMed, Scopus, ISI Web of Science, and Embase databases until July 5, 2025. In vitro and in situ original studies that investigated the effects of plant-based interventions on dental erosion, with a control group, were included. In vivo studies and those plants combined with non-plant substances were excluded. Risk of bias was assessed using the QUIN tool. Meta-analyses were performed when appropriate. Mechanical and ultrastructure assessments used to evaluate surface loss, hardness, and morphological changes were also reviewed.

Results

Out of 1119 studies, 38 studies met the inclusion criteria; 22 studies assessed preventive effects, and 18 assessed the therapeutic effects, and one study that evaluated both the effects. Most studies had a medium risk of bias. Meta-analysis showed that quercetin as a preventive measure, significantly reduced dentin loss by 4.95 µm with high heterogeneity (I² = 98%). For therapeutic measures, green tea reduced dentin loss by 0.89 µm, whereas epigallocatechin-3-gallate (EGCG) did not significantly decrease dentin loss. The two analyses were heterogeneous (I² = 99%). Quercetin significantly decreased dentin loss by 4.19 µm with low heterogeneity (I² = 0%).

Conclusions

Plants with polyphenols may modify the pellicle layer ultrastructure to protect teeth from erosion. Quercetin (the most common flavonoid in fruit and vegetables) has preventive and therapeutic effects on dentin erosion. Green tea (because of its elevated catechin content) has therapeutic effects on dentin erosion.

目的：牙蚀是牙釉质和牙本质的非细菌性、不可逆的病理溶解，主要受生活方式的影响。本系统综述和荟萃分析旨在利用体外和原位研究的证据来评估植物源性化合物对牙齿侵蚀的预防和治疗作用。材料和方法：该综述已在PROSPERO注册（CRD42023493906），并在PubMed、Scopus、ISI Web of Science和Embase数据库中检索至2025年7月5日。在体外和原位研究中，研究了基于植物的干预措施对牙侵蚀的影响，并纳入了对照组。排除了体内研究和植物与非植物物质结合的研究。使用QUIN工具评估偏倚风险。适当时进行meta分析。力学和超微结构评估用于评估表面损失，硬度和形态变化也进行了综述。结果：1119项研究中，38项研究符合纳入标准；22项研究评估了预防效果，18项评估了治疗效果，还有一项研究对两种效果都进行了评估。大多数研究有中等偏倚风险。meta分析显示，槲皮素作为预防措施，可显著减少牙本质损失4.95µm，异质性高（I2 = 98%）。在治疗措施中，绿茶减少了0.89µm的牙本质损失，而表没食子儿茶素-3-没食子酸酯（EGCG）没有显著减少牙本质损失。这两个分析是异质的（I2 = 99%）。槲皮素显著降低牙本质损失4.19µm，异质性低（I2 = 0%）。结论：多酚类植物可改变牙膜层超微结构，保护牙齿免受侵蚀。槲皮素（水果和蔬菜中最常见的类黄酮）对牙本质侵蚀具有预防和治疗作用。绿茶（因为它的儿茶素含量升高）对牙本质侵蚀有治疗作用。

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引用次数: 0

Effectiveness of Cleaning Methods for Resilient Denture Liners: A Three-Period Randomized Crossover Trial 弹性义齿衬套清洁方法的有效性：一项三期随机交叉试验。

IF 2.2 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research

Pub Date : 2025-10-18 DOI: 10.1002/cre2.70243

Rihoko Takeuchi, Shin Miyamae, Nana Sonobe, Humika Hattori, Yuei Morinaga, Hisato Hotta, Yoshiaki Hasegawa, Suguru Kimoto

Objective

Several studies have demonstrated that insufficient denture hygiene constitutes a significant risk factor for aspiration pneumonia. While various cleaning protocols have been proposed for conventional hard denture base materials, there remains a notable paucity of research specifically addressing effective cleaning strategies for resilient denture liners (RDLs). This study aimed to evaluate the efficacy of three denture cleaning methods—mechanical, chemical, and dual (combined mechanical and chemical)—for removing microbial biofilms from different denture-liner materials using a randomized crossover clinical trial.

Materials and Methods

This three-period randomized crossover clinical trial included edentulous patients wearing maxillary complete dentures embedded with specimens of a hard-resin liner and silicone-based and acrylic-based RDLs. All liners were fabricated directly in the patient's mouth. Participants performed the three cleaning interventions for 2 weeks each. Swabs from the relined denture surfaces were cultured in phosphate-buffered saline, and the colony-forming units (CFUs) were counted. The influence of each cleaning method on the CFU count was determined.

Results

The dual-cleaning method demonstrated a significant reduction in CFU count compared to mechanical cleaning, but only for the acrylic-based RDL. No significant differences were observed between the cleaning methods for the silicone-based RDL and hard-resin liner. The CFU count was the highest for silicone-based RDLs, followed by that for acrylic-based RDLs, and hard-resin liners.

Conclusion

The dual method comprising mechanical and chemical cleaning was the most effective cleaning strategy for relined dentures, although the advantage was limited to acrylic-based RDL.

Trial Registration

This study was registered in the UMIN Clinical Trials Registry (UMIN000056738).

目的：多项研究表明，义齿卫生不良是吸入性肺炎的重要危险因素。虽然针对传统的硬质义齿基托材料提出了各种清洁方案，但针对弹性义齿衬套（rdl）的有效清洁策略的研究仍然非常缺乏。本研究旨在通过随机交叉临床试验评估三种义齿清洁方法-机械、化学和双重（机械和化学结合）-去除不同义齿衬垫材料上微生物生物膜的效果。材料和方法：这项为期3期的随机交叉临床试验纳入了无牙患者，他们佩戴的上颌全口义齿嵌有硬树脂衬里、硅基和丙烯酸基rdll标本。所有衬套均直接在患者口腔内制作。参与者分别进行了为期两周的三种清洁干预。将义齿表面拭子置于磷酸盐缓冲盐水中培养，计数菌落形成单位（cfu）。测定各清洗方法对CFU计数的影响。结果：与机械清洗相比，双重清洗方法显示CFU计数显著减少，但仅适用于丙烯酸基RDL。硅基RDL和硬树脂衬垫的清洗方法无显著差异。硅基RDLs的CFU计数最高，其次是丙烯酸基RDLs，然后是硬树脂衬垫。结论：机械清洗和化学清洗是修复义齿最有效的方法，但其优势仅限于丙烯酸基RDL。试验注册：本研究已在UMIN临床试验注册中心注册（UMIN000056738）。

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引用次数: 0

Assessment of Deep Convolutional Neural Network Models for the Classification of Benign Fibro-Osseous Lesions of the Jaws 深度卷积神经网络模型对颌骨良性纤维骨性病变分类的评价

IF 2.2 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research

Pub Date : 2025-10-16 DOI: 10.1002/cre2.70244

Paniti Achararit, Chawan Manaspon, Chavin Jongwannasiri, Kraisorn Sappayatosok, Thanaphum Osathanon, Ekarat Phattarataratip

Objectives

Benign fibro-osseous lesions (BFOL) constitute a group of pathologic entities with marked overlapping histopathologic features but are diverse in nature and clinical behaviors. Accurate diagnoses of BFOLs necessitate clinical-pathological correlations, which are paramount for their appropriate management. Recent research indicates the potential utility of artificial intelligence in diagnostic pathology. Here, we aimed to assess the performance of the deep convolutional neural network (DCNN) models for BFOL classification and investigate its impact on the diagnostic performance of oral pathologists.

Material and Methods

Microscopic slides from 68 patients diagnosed with cemento-ossifying fibroma (COF), fibrous dysplasia (FD), and cemento-osseous dysplasia (COD) were collected. The image patches from each slide were processed, augmented, and used to train and validate the five pre-trained DCNN models for BFOL classification. The best-performing model was selected to evaluate its diagnostic performance on the testing data set, compared with experienced oral pathologists.

Results

The InceptionV3 model showed the highest and most balanced overall performance in BFOL classification. It demonstrated the highest accuracy (96.7%) in classifying COF, followed by COD (83.3%), and FD (80.0%), respectively. The model accuracy in identifying COF was greater than the average performance of pathologists (90.0%). However, pathologists performed better in classifying COD (87.2%) and FD (95.0%). With DCNN assistance, pathologists significantly improved the accuracy, sensitivity, and specificity in distinguishing BFOLs while reducing the average diagnosis time.

Conclusions

The DCNN model has the potential to be developed as an auxiliary tool, assisting pathologists in diagnosing BFOLs. Through ongoing refinements, artificial intelligence assistance can aid pathologists in enhancing the accuracy and efficiency of BFOL diagnosis.

目的良性纤维骨性病变（BFOL）是一组病理实体，具有明显的组织病理特征重叠，但在性质和临床表现上各不相同。准确诊断BFOLs需要临床病理相关性，这对其适当治疗至关重要。最近的研究表明，人工智能在诊断病理学中的潜在效用。在这里，我们旨在评估深度卷积神经网络（DCNN）模型在BFOL分类中的性能，并研究其对口腔病理学家诊断性能的影响。材料与方法收集了68例骨质骨化纤维瘤（COF）、纤维发育不良（FD）和骨质发育不良（COD）患者的显微切片。对每张幻灯片的图像块进行处理、增强，并用于训练和验证5个预训练的DCNN模型，用于BFOL分类。选择表现最好的模型在测试数据集上评估其诊断性能，并与经验丰富的口腔病理学家进行比较。结果InceptionV3模型在BFOL分类中表现出最高、最平衡的综合性能。COF分类准确率最高（96.7%），COD次之（83.3%），FD次之（80.0%）。模型识别COF的准确率高于病理学家的平均水平（90.0%）。但病理医师对COD（87.2%）和FD（95.0%）的分类较好。在DCNN的帮助下，病理学家在区分BFOLs的准确性、敏感性和特异性显著提高，同时减少了平均诊断时间。结论DCNN模型可作为一种辅助诊断BFOLs的工具。通过不断的改进，人工智能辅助可以帮助病理学家提高BFOL诊断的准确性和效率。

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引用次数: 0

Peri-Implantitis and Survival Outcomes of Tissue Level Versus Bone Level Dental Implants: A Systematic Review and Meta-Analysis 组织水平与骨水平牙种植体的种植周围炎和生存结果：系统回顾和荟萃分析。

IF 2.2 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research

Pub Date : 2025-10-16 DOI: 10.1002/cre2.70242

Momen A. Atieh, Maanas Shah, Abeer Hakam, Ahmad Aid, Andrew Tawse-Smith, Nabeel H. M. Alsabeeha

Objectives

The aim of this systematic review and meta-analyses was to evaluate the outcomes of using tissue level in comparison to bone level implants in terms of clinical and radiographic changes, peri-implantitis, and implant failure rates.

Materials and Methods

Electronic databases were searched to identify randomized studies that compared tissue level to bone level implant. The risk of bias was assessed using the Cochrane Collaboration's Risk of Bias tool. Data were analyzed using a statistical software program.

Results

A total of 798 studies were identified, of which, five studies with 501 dental implants in 241 participants were included. Overall meta-analysis showed that the use of tissue level implants had lower rates of peri-implantitis (relative risk [RR] 0.59; 95% confidence interval [CI] 0.14–2.48; p = 0.47) and implant failure (RR 0.59; 95% CI 0.07–4.69; p = 0.62) but the differences were not statistically significant.

Conclusions

Tissue level and bone level have comparable survival rates and risk of peri-implantitis within 1–5 years of observation. Additionally, no significant differences in probing pocket depths and marginal bone level changes were observed.

Clinical Relevance

Tissue level implants demonstrated lower rates of peri-implantitis and implant failure, as well as smaller changes in probing pocket depths at 12 and 24 months, compared to bone level implants. Although these differences were not statistically significant, they suggest potential clinical advantages of tissue level implants in maintaining peri-implant health and stability over time.

目的：本系统综述和荟萃分析的目的是在临床和影像学改变、种植体周围炎和种植体失败率方面评估使用组织水平种植体与骨水平种植体的结果。材料和方法：检索电子数据库以确定比较组织水平和骨水平种植体的随机研究。使用Cochrane协作的偏倚风险工具评估偏倚风险。使用统计软件程序对数据进行分析。结果：共纳入798项研究，其中纳入5项研究，共纳入501颗种植体，共纳入241名受试者。整体荟萃分析显示，使用组织水平种植体的种植体周围炎发生率（相对危险度[RR] 0.59； 95%可信区间[CI] 0.14-2.48; p = 0.47）和种植体失败发生率（RR 0.59; 95% CI 0.07-4.69; p = 0.62）较低，但差异无统计学意义。结论：在1-5年的观察中，组织水平和骨水平的生存率和种植体周围炎的风险相当。此外，在探查袋深度和边缘骨水平变化方面没有观察到显著差异。临床相关性：与骨水平种植体相比，组织水平种植体显示出较低的种植体周围炎和种植体失败率，并且在12和24个月时探测袋深度的变化较小。尽管这些差异在统计学上不显著，但它们表明组织水平种植体在长期维持种植体周围健康和稳定方面具有潜在的临床优势。

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引用次数: 0

Exploring the Link Between Social Capital and Edentulism in Low- and Middle-Income Countries 探讨中低收入国家社会资本与无齿主义的关系。

IF 2.2 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research

Pub Date : 2025-10-14 DOI: 10.1002/cre2.70241

Saida Ben-Bihi, Yanfei Guo, Richard Olofsson, Hülya Çevik-Aras, Junmei Miao Jonasson

Objectives

Although social capital (SC) has received growing attention in public health, no research has yet compared how SC and oral health are associated in diverse contexts. This cross-sectional study aims to examine the association of community and individual-level SC with edentulism among adults aged 50 and above in five low- and middle-income countries (LMICs).

Materials and Methods

Data are from SAGE-wave 1 (2007–2010), including 27,676 participants aged 50 years or older from China (N = 12,830), Ghana (N = 4261), India (N = 6040), Mexico (N = 1327), and South Africa (N = 3218). The primary outcome was self-reported edentulism. Cognitive and structural SC were used to measure SC at the individual and community levels. The association between SC dimensions and oral health was investigated using a two-level multilevel logistic regression.

Results

Multilevel analysis revealed that low individual and community structural SC are independently associated with edentulism in China (OR 1.43; CI 1.08–1.89 and OR 1.95; CI 1.32–2.90, respectively). In South Africa, low individual cognitive SC was negatively associated with edentulism (OR 0.48; CI 0.24–0.98), while low individual structural SC was positively associated with edentulism (OR 2.34; CI 1.16–4.74). In Ghana, only participants living in middle community structural SC had higher odds of being edentulous after adjustment for all potential confounders (OR 1.78; CI 0.71–2.96). In Mexico and India, no association was found between any dimensions of SC and oral health.

Conclusion

The dimensions of SC and its relationship to edentulism differed across the five LMICs. Our study highlights the importance of considering contextual factors when analyzing the relationship between SC and oral health. Further research is required to understand how SC influences oral health in LMICs.

目的：虽然社会资本（SC）在公共卫生领域受到越来越多的关注，但尚未有研究比较社会资本与口腔健康在不同背景下的关系。本横断面研究旨在研究五个低收入和中等收入国家（LMICs）中50岁及以上成年人中社区和个人水平SC与牙髓病的关系。材料和方法：数据来自SAGE-wave 1(2007-2010)，包括27,676名年龄在50岁及以上的参与者，分别来自中国（N = 12,830）、加纳（N = 4261）、印度（N = 6040）、墨西哥（N = 1327）和南非（N = 3218）。主要结果是自我报告的龋齿。认知SC和结构SC分别用于个体和社区水平的SC测量。SC维度与口腔健康之间的关系采用双水平多水平逻辑回归进行调查。结果：多水平分析显示，低个体和低社区结构SC与中国的牙髓发育独立相关（OR 1.43; CI 1.08-1.89和OR 1.95; CI 1.32-2.90）。在南非，低个体认知性SC与蛀牙症呈负相关（OR 0.48; CI 0.24-0.98），而低个体结构性SC与蛀牙症呈正相关（OR 2.34; CI 1.16-4.74）。在加纳，只有生活在中间社区结构性SC的参与者在调整所有潜在混杂因素后，无牙的几率更高（OR 1.78; CI 0.71-2.96）。在墨西哥和印度，没有发现SC的任何方面与口腔健康之间的联系。结论：5个中低收入国家的牙床量表及其与牙床的关系存在差异。我们的研究强调了在分析SC与口腔健康之间的关系时考虑环境因素的重要性。需要进一步的研究来了解SC如何影响中低收入国家的口腔健康。

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引用次数: 0

Epidemiology of Endodontic Treatment in Far North Queensland, Australia: A Retrospective Observational Study of 11 Years 澳大利亚昆士兰州远北地区根管治疗的流行病学：一项11年的回顾性观察研究。

IF 2.2 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research

Pub Date : 2025-10-14 DOI: 10.1002/cre2.70232

Aditya Suvarna, Preethi Thennarasu, Sona Sojan, Olivia Gables, Daniel J. Browne, Rodrigo R. Amaral

Objectives

This retrospective observational study assessed demographics, geographical influences, and diagnostic trends in patients receiving endodontic treatment at James Cook University dental clinics between 2011 and 2022. Patient demographics (sex and age), treatment timing, and care types were examined, with a focus on regional and rural disparities in access to endodontic care.

Material and Methods

Data were extracted from electronic dental records from 2011 to 2022 using service item codes under the “Endodontics section (codes 411–459)” of the Australian Schedule of Dental Services and Glossary. The Modified Monash Model framework was used to assess geographical disparities in treatment access.

Results

Females sought treatment earlier than males, who often presented later with more severe symptoms. Older males were more likely to present with pulpal necrosis and chronic apical abscesses, whereas females had higher rates of previously initiated endodontic therapy and asymptomatic apical periodontitis. A total of 2932 patients were treated, with tooth 46 being the most treated (7.54%).

Conclusions

Significant geographical disparities in endodontic treatment timing exist, with rural and remote patients experiencing delays in treatment. These findings highlight the need for improved access to specialized dental care, particularly in underserved areas.

目的：这项回顾性观察性研究评估了2011年至2022年在詹姆斯库克大学牙科诊所接受牙髓治疗的患者的人口统计学、地理影响和诊断趋势。对患者人口统计（性别和年龄）、治疗时机和护理类型进行了检查，重点关注地区和农村在获得牙髓治疗方面的差异。材料和方法：数据从2011年至2022年的电子牙科记录中提取，使用澳大利亚牙科服务和术语表“牙髓学部分（代码411-459）”下的服务项目代码。改进的莫纳什模型框架用于评估治疗可及性的地理差异。结果：女性比男性更早寻求治疗，男性往往出现更晚，症状更严重。老年男性更有可能出现牙髓坏死和慢性根尖脓肿，而女性有更高的比例，以前进行过牙髓治疗和无症状的根尖牙周炎。共治疗2932例患者，其中治疗最多的是46牙（7.54%）。结论：牙髓治疗时间存在明显的地域差异，农村和偏远地区患者出现治疗延误。这些发现突出表明，需要改善获得专业牙科护理的机会，特别是在服务不足的地区。

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引用次数: 0