Katja Hashemi Elses, Krister Bjerklin, Ann-Marie Roos Jansåker, Mikael Sonesson
Objectives
To evaluate treatment time and patient perception of two surgical methods to expose a palatally displaced canine (PDC) into the oral cavity.
Material and Methods
A total of 30 consecutive patients between 11 and 18 years, with maxillary displaced canines were recruited. After gaining informed consent from the patients and custodians, the patients were randomized into two groups by an independent person. Both groups received a chain attached to the crown of the canine: in group A (control group) the chain was placed under the mucoperiosteal flap to an incision on the alveolar crest and in group B (test group), the chain penetrated the mucoperiosteal flap inferiorly to the crown of the canine. Outcome measures where time to expose the PDC into the oral cavity and the patient's experience of pain and discomfort during the treatment.
Results
Twenty-six patients full-filled the trial, mean age was 12.9 years, (SD 1.6 years). The time to expose the canines for the control group was 11.9 months (SD 6.5) and for the test group 6.7 months (SD 3.2) The conventional method showed less pain on the day of surgery.
Conclusion
The method used in the test group resulted in a 5-month shorter time to expose the canine compared to the control group, and higher pain level on the day of surgery. For generalizability of the results, larger studies are needed.
{"title":"Treatment of Palatally Displaced Canines in Children: A Randomized Controlled Pilot Trial on Exposure Time and Patient Perception of Two Closed Surgical Methods","authors":"Katja Hashemi Elses, Krister Bjerklin, Ann-Marie Roos Jansåker, Mikael Sonesson","doi":"10.1002/cre2.70233","DOIUrl":"10.1002/cre2.70233","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate treatment time and patient perception of two surgical methods to expose a palatally displaced canine (PDC) into the oral cavity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>A total of 30 consecutive patients between 11 and 18 years, with maxillary displaced canines were recruited. After gaining informed consent from the patients and custodians, the patients were randomized into two groups by an independent person. Both groups received a chain attached to the crown of the canine: in group A (control group) the chain was placed under the mucoperiosteal flap to an incision on the alveolar crest and in group B (test group), the chain penetrated the mucoperiosteal flap inferiorly to the crown of the canine. Outcome measures where time to expose the PDC into the oral cavity and the patient's experience of pain and discomfort during the treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty-six patients full-filled the trial, mean age was 12.9 years, (SD 1.6 years). The time to expose the canines for the control group was 11.9 months (SD 6.5) and for the test group 6.7 months (SD 3.2) The conventional method showed less pain on the day of surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The method used in the test group resulted in a 5-month shorter time to expose the canine compared to the control group, and higher pain level on the day of surgery. For generalizability of the results, larger studies are needed.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12516783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145279034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah Arzani, Erfan Khorasani, Aida Mokhlesi, Shima Azadian, Safoura Ghodsi, Seyed Ali Mosaddad
Objective
To systematically compare the bond strength of denture teeth and reline materials to additively manufactured (AM) versus subtractively milled (SM) denture base resins and to identify the material- and process-related factors influencing bonding performance.
Materials and Methods
A systematic electronic search of PubMed, Scopus, Embase, Web of Science, the Cochrane Library, and Google Scholar was conducted up to December 10, 2024. Eligible in vitro studies comparing bond strength at either the tooth–base or reline–base interface using AM and SM denture bases were included. Studies that lacked direct comparison, involved conventional heat-polymerized bases, or did not report quantitative bond strength data were excluded. Meta-analyses were performed using random-effects models, calculating mean differences (MD) for tooth bonding and standardized mean differences (SMD) for reline bonding. Subgroup, sensitivity, and publication bias analyses (Egger's regression and Begg's rank tests) were included. Risk of bias was evaluated using QUIN tools.
Results
Out of 2985 screened records, 20 studies comprising 156 independent comparisons were included; 41 for tooth bonding and 115 for reline bonding. Initial tooth-bonding meta-analysis revealed no significant difference; however, after exclusion of two outlier comparisons identified through sensitivity analysis (n = 39), milled bases demonstrated significantly higher bond strength (MD = −2.43 MPa, 95% CI–3.90 to −0.96; p = 0.001). For reline bonding, AM bases consistently underperformed across all studies, with the pooled estimate favoring milled bases (SMD = −2.62, 95% CI–3.22 to −2.03; p = 0.001).
Conclusion
Within the limitations of this review, milled denture bases demonstrate consistently stronger and more reliable bonding to both teeth and reline materials than current printable photopolymer bases.
{"title":"How Does the Bonding Strength of Reline Materials and Denture Teeth Vary Between 3D-Printed and Milled Complete Denture Bases? A Systematic Review and Meta-Analysis","authors":"Sarah Arzani, Erfan Khorasani, Aida Mokhlesi, Shima Azadian, Safoura Ghodsi, Seyed Ali Mosaddad","doi":"10.1002/cre2.70234","DOIUrl":"10.1002/cre2.70234","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To systematically compare the bond strength of denture teeth and reline materials to additively manufactured (AM) versus subtractively milled (SM) denture base resins and to identify the material- and process-related factors influencing bonding performance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A systematic electronic search of PubMed, Scopus, Embase, Web of Science, the Cochrane Library, and Google Scholar was conducted up to December 10, 2024. Eligible in vitro studies comparing bond strength at either the tooth–base or reline–base interface using AM and SM denture bases were included. Studies that lacked direct comparison, involved conventional heat-polymerized bases, or did not report quantitative bond strength data were excluded. Meta-analyses were performed using random-effects models, calculating mean differences (MD) for tooth bonding and standardized mean differences (SMD) for reline bonding. Subgroup, sensitivity, and publication bias analyses (Egger's regression and Begg's rank tests) were included. Risk of bias was evaluated using QUIN tools.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Out of 2985 screened records, 20 studies comprising 156 independent comparisons were included; 41 for tooth bonding and 115 for reline bonding. Initial tooth-bonding meta-analysis revealed no significant difference; however, after exclusion of two outlier comparisons identified through sensitivity analysis (<i>n</i> = 39), milled bases demonstrated significantly higher bond strength (MD = −2.43 MPa, 95% CI–3.90 to −0.96; <i>p</i> = 0.001). For reline bonding, AM bases consistently underperformed across all studies, with the pooled estimate favoring milled bases (SMD = −2.62, 95% CI–3.22 to −2.03; <i>p</i> = 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Within the limitations of this review, milled denture bases demonstrate consistently stronger and more reliable bonding to both teeth and reline materials than current printable photopolymer bases.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yena Gan, Duoduo Li, He Xu, Sheng Han, He Zhu, Zening Wei, Zhigang Cai, Jinwei Huang
Objectives
The phosphoinositide 3 kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway is a key therapeutic target for oral diseases. This study uses bibliometric analysis to identify research trends, knowledge gaps, and the development of PI3K/AKT/mTOR-targeted therapies.
Methods
A systematic literature search was conducted in March 2025 using the keywords “PI3K/AKT/mTOR” and “dental OR oral.” Publication trends, highly cited studies, research hotspots, and emerging trends were analyzed. Comparative analyses of publication year, study design, and disease categories were performed between Asian and non-Asian cohorts.
Results
From 2008 to 2025, 119 studies were identified, with China, India, and Japan leading in publications and citations. Germany had the highest average citations. Keyword analysis showed a shift from basic to clinical research. Of these studies, 91 were from Asia, covering a broader range of oral conditions, while 28 were from non-Asian regions, with no significant differences in study design or disease categories.
Conclusion
This bibliometric analysis shows rising global interest in PI3K/AKT/mTOR research in oral science, led by Asia. Research has shifted from basic signaling to disease-focused studies, with future efforts focusing on underexplored oral pathologies and translational applications, particularly in targeted therapy and regenerative medicine.
目的：磷酸肌肽3激酶(PI3K)/蛋白激酶B (AKT)/哺乳动物雷帕霉素靶点（mTOR）信号通路是口腔疾病的关键治疗靶点。本研究使用文献计量学分析来确定研究趋势、知识差距以及PI3K/AKT/ mtor靶向治疗的发展。方法：于2025年3月以“PI3K/AKT/mTOR”和“dental OR oral”为关键词进行系统文献检索。分析了出版物趋势、高被引研究、研究热点和新兴趋势。在亚洲和非亚洲队列之间进行了发表年份、研究设计和疾病类别的比较分析。结果：从2008年到2025年，共确定了119项研究，其中中国、印度和日本在发表和引用方面处于领先地位。德国的平均引用次数最高。关键词分析显示从基础研究到临床研究的转变。在这些研究中，91项来自亚洲，涵盖了更广泛的口腔状况，而28项来自非亚洲地区，在研究设计或疾病类别方面没有显著差异。结论：这项文献计量分析显示，全球对口腔科学中PI3K/AKT/mTOR研究的兴趣正在上升，以亚洲为首。研究已经从基础信号转向以疾病为重点的研究，未来的努力将集中在尚未开发的口腔病理学和转化应用，特别是在靶向治疗和再生医学方面。
{"title":"The PI3K/AKT/mTOR Pathway and Oral Diseases: A Bibliometric Analysis From 2008 to 2025","authors":"Yena Gan, Duoduo Li, He Xu, Sheng Han, He Zhu, Zening Wei, Zhigang Cai, Jinwei Huang","doi":"10.1002/cre2.70238","DOIUrl":"10.1002/cre2.70238","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The phosphoinositide 3 kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway is a key therapeutic target for oral diseases. This study uses bibliometric analysis to identify research trends, knowledge gaps, and the development of PI3K/AKT/mTOR-targeted therapies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic literature search was conducted in March 2025 using the keywords “PI3K/AKT/mTOR” and “dental OR oral.” Publication trends, highly cited studies, research hotspots, and emerging trends were analyzed. Comparative analyses of publication year, study design, and disease categories were performed between Asian and non-Asian cohorts.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>From 2008 to 2025, 119 studies were identified, with China, India, and Japan leading in publications and citations. Germany had the highest average citations. Keyword analysis showed a shift from basic to clinical research. Of these studies, 91 were from Asia, covering a broader range of oral conditions, while 28 were from non-Asian regions, with no significant differences in study design or disease categories.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This bibliometric analysis shows rising global interest in PI3K/AKT/mTOR research in oral science, led by Asia. Research has shifted from basic signaling to disease-focused studies, with future efforts focusing on underexplored oral pathologies and translational applications, particularly in targeted therapy and regenerative medicine.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jörg Philipp Tchorz, Patrizia Ladar, Maria Lessani, Sebastian Fitzek
Objectives
The Covid-19 pandemic increased stress, which may have led to more bruxism, TMDs, and thus tooth fractures. While previous studies, primarily from specialized clinics, reported an increase in cracked teeth during the pandemic, this retrospective study aimed to assess whether similar trends were observed in a general dental practice in Bavaria, Germany, which remained fully operational throughout the pandemic.
Material and Methods
Patient records from 2018 to 2023 (n = 4709 patients, 10,018 visits) were analyzed for symptomatic tooth fractures, categorized as wall/cusp fractures, incomplete cracks, or complete fractures.
Results
Statistical analysis using the Mann–Whitney U test revealed no significant differences in fracture incidence between pre-pandemic (2018–2019), pandemic (2020–2021), and post-pandemic (2022–2023) periods. Mandibular molars were the most frequently affected teeth (7.94%–12.43%), and composite restorations were most associated with fractures (51.85%).
Conclusions
Contrary to previous findings from endodontic practices, this study found no pandemic-related surge in tooth fractures, suggesting that referral bias or patient selection in specialized settings may influence reported trends.
{"title":"Incidence of Cracked Teeth Before, During, and After the Covid-19 Pandemic—A Retrospective Analysis in a German Private General Practice","authors":"Jörg Philipp Tchorz, Patrizia Ladar, Maria Lessani, Sebastian Fitzek","doi":"10.1002/cre2.70239","DOIUrl":"10.1002/cre2.70239","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The Covid-19 pandemic increased stress, which may have led to more bruxism, TMDs, and thus tooth fractures. While previous studies, primarily from specialized clinics, reported an increase in cracked teeth during the pandemic, this retrospective study aimed to assess whether similar trends were observed in a general dental practice in Bavaria, Germany, which remained fully operational throughout the pandemic.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Patient records from 2018 to 2023 (<i>n</i> = 4709 patients, 10,018 visits) were analyzed for symptomatic tooth fractures, categorized as wall/cusp fractures, incomplete cracks, or complete fractures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Statistical analysis using the Mann–Whitney <i>U</i> test revealed no significant differences in fracture incidence between pre-pandemic (2018–2019), pandemic (2020–2021), and post-pandemic (2022–2023) periods. Mandibular molars were the most frequently affected teeth (7.94%–12.43%), and composite restorations were most associated with fractures (51.85%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Contrary to previous findings from endodontic practices, this study found no pandemic-related surge in tooth fractures, suggesting that referral bias or patient selection in specialized settings may influence reported trends.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dental caries remains a major public health concern globally. This study aimed to assess the dental caries status and its associated factors among adults in Southeastern Iran.
Material and Methods
This cross-sectional study included 10,016 adults aged 35–70 years who participated in the Zahedan Adult Cohort Study (ZACS). The status of dental caries was assessed using the decayed, missing, and filled teeth (DMFT) index. Data on sociodemographic characteristics, oral hygiene practices, presence of oral lesions, current cigarette smoking and drug use, and history of chronic condition were collected through valid questionnaires from the ZACS. One-factor and multifactor general linear models were used to identify significant factors associated with DMFT.
Results
In this study, 99.4% of participants had a DMFT score of 1 or higher, indicating a high lifetime experience of dental caries. The mean DMFT score was 17.3. Additionally, 47.91% of participants had filled teeth (1), and 78.7% had decayed teeth (DT), with the 35–40 age group showing the lowest mean DT score of 3.65. Conversely, individuals over 60 had the highest DMFT score of 22.88. In the multifactor model, DMFT significantly increased with age and decreased with higher education levels. DMFT also decreased from underweight to obese individuals. Furthermore, DMFT significantly decreased with increased daily tooth brushing, while cigarette smokers and drug users exhibited significantly higher DMFT scores.
Conclusions
This study revealed significant variations in DMFT scores based on age, education, and oral hygiene practices among adults in Southeastern Iran, highlighting the importance of consistent dental brushing. The findings suggest the need for targeted public health interventions, particularly for smokers, drug users, and less educated populations, to address oral health challenges and reduce dental caries prevalence.
{"title":"Dental Caries Status and Associated Factors Among Adults in Southeastern Iran: Findings From the Zahedan Adult Cohort Study","authors":"Somaye Ansari Moghadam, Razie Keikha Arya, Hassan Okati-Aliabad, Mahdi Mohammadi, Alireza Ansari-Moghaddam","doi":"10.1002/cre2.70236","DOIUrl":"10.1002/cre2.70236","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Dental caries remains a major public health concern globally. This study aimed to assess the dental caries status and its associated factors among adults in Southeastern Iran.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>This cross-sectional study included 10,016 adults aged 35–70 years who participated in the Zahedan Adult Cohort Study (ZACS). The status of dental caries was assessed using the decayed, missing, and filled teeth (DMFT) index. Data on sociodemographic characteristics, oral hygiene practices, presence of oral lesions, current cigarette smoking and drug use, and history of chronic condition were collected through valid questionnaires from the ZACS. One-factor and multifactor general linear models were used to identify significant factors associated with DMFT.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In this study, 99.4% of participants had a DMFT score of 1 or higher, indicating a high lifetime experience of dental caries. The mean DMFT score was 17.3. Additionally, 47.91% of participants had filled teeth (1), and 78.7% had decayed teeth (DT), with the 35–40 age group showing the lowest mean DT score of 3.65. Conversely, individuals over 60 had the highest DMFT score of 22.88. In the multifactor model, DMFT significantly increased with age and decreased with higher education levels. DMFT also decreased from underweight to obese individuals. Furthermore, DMFT significantly decreased with increased daily tooth brushing, while cigarette smokers and drug users exhibited significantly higher DMFT scores.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study revealed significant variations in DMFT scores based on age, education, and oral hygiene practices among adults in Southeastern Iran, highlighting the importance of consistent dental brushing. The findings suggest the need for targeted public health interventions, particularly for smokers, drug users, and less educated populations, to address oral health challenges and reduce dental caries prevalence.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145237849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neda Babanouri, Roghayeh Baghandeh, Kimia Kiumarsi
Aim
To evaluate and compare the dentoskeletal and soft tissue effects of the PowerScope and Twin Block appliances for treating Class II malocclusions.
Materials and Methods
This retrospective study analyzed pre- (T0) and posttreatment (T1) cephalograms of 14 patients treated with PowerScope (Group A) and 17 patients treated with Twin Block (Group B). Thirty-three cephalometric variables were assessed. Statistical analysis included paired and independent t-tests or their non-parametric equivalents.
Results
Both groups showed significant improvements in soft tissue profiles. The Twin Block group demonstrated a significantly greater increase in SNB angle (p = 0.048) and more pronounced changes in UL-SnPog' and LL-SnPog’ posttreatment (p = 0.021 for both). The PowerScope group exhibited significantly greater increases in IMPA and Md-NB (p = 0.029 and p < 0.001, respectively) and a significantly shorter treatment duration (p < 0.0001).
Conclusion
Both appliances effectively treat Class II malocclusion and improve lip positioning. The Twin Block appliance is associated with greater mandibular skeletal advancement, while the PowerScope appliance leads to greater lower incisor protrusion and a shorter treatment time.
{"title":"Evaluation of the PowerScope Appliance Effects on the Dentoskeletal and Soft Tissue for the Treatment of Class II Malocclusions","authors":"Neda Babanouri, Roghayeh Baghandeh, Kimia Kiumarsi","doi":"10.1002/cre2.70230","DOIUrl":"10.1002/cre2.70230","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate and compare the dentoskeletal and soft tissue effects of the PowerScope and Twin Block appliances for treating Class II malocclusions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This retrospective study analyzed pre- (T0) and posttreatment (T1) cephalograms of 14 patients treated with PowerScope (Group A) and 17 patients treated with Twin Block (Group B). Thirty-three cephalometric variables were assessed. Statistical analysis included paired and independent <i>t</i>-tests or their non-parametric equivalents.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Both groups showed significant improvements in soft tissue profiles. The Twin Block group demonstrated a significantly greater increase in SNB angle (<i>p</i> = 0.048) and more pronounced changes in UL-SnPog' and LL-SnPog’ posttreatment (<i>p</i> = 0.021 for both). The PowerScope group exhibited significantly greater increases in IMPA and Md-NB (<i>p</i> = 0.029 and <i>p</i> < 0.001, respectively) and a significantly shorter treatment duration (<i>p</i> < 0.0001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Both appliances effectively treat Class II malocclusion and improve lip positioning. The Twin Block appliance is associated with greater mandibular skeletal advancement, while the PowerScope appliance leads to greater lower incisor protrusion and a shorter treatment time.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To compare the effect of polycaprolactone impregnated 3D printed nano-hydroxyapatite (3DPHA-PCL) with bovine bone substitute material (BB) in lateral maxillary sinus floor elevation (MSFE).
Materials and Methods
Lateral MSFE with two bone substitute materials was randomly performed in two centers: group BB (n = 11 sinuses) or group 3DPHA-PCL (n = 11 sinuses). Lateral MSFE with two bone substitute materials was performed on 21 participants across two centers, resulting in a total of 22 sinuses analyzed. The sinuses were randomly allocated into two groups: group BB (11 sinuses) and group 3DPHA-PCL (11 sinuses). Cone beam computed tomography (CBCT) was taken before (T0) and immediately after MSFE (T1), at 6 months (implant placement; T2), and 1 year (T3). Dimensional stability of the augmentation was analyzed using serial CBCT scans. At the time of implant placement, bone core biopsy was performed, followed by microcomputed tomographic (micro-CT) and histomorphometric analyses.
Results
Based on the superimposed CBCT images between T1 and T2, the augmented height and volume decreased in both groups without a statistically significant difference between the groups (−0.48 ± 1.01 mm, −53.9 ± 117.8 mm3 in group BB vs. −0.39 ± 0.44 mm, −40.8 ± 101.2 mm3 in group 3DPHA-PCL, p > 0.05). The percentage of newly formed bone was statistically significantly lower in group 3DPHA-PCL (15.7 ± 7.5% histomorphometrically, 16.7 ± 7.5% in micro-CT) than group BB (25.6 ± 7.2%, 26.3 ± 4.1%) (p < 0.05 in both methods). Two implants failed in the 3DPHA-PCL group, while no failures in the BB group.
Conclusions
Dimensional stability of the augmented bone was comparable between the groups. However, group 3DPHA-PCL demonstrated inferior new bone formation and implant survival compared to group BB. Long-term follow-up is warranted to monitor the behavior of 3DPHA-PCL.
目的：比较聚己内酯浸渍3D打印纳米羟基磷灰石（3DPHA-PCL）与牛骨替代材料（BB）在上颌侧窦底提升（MSFE）中的效果。材料和方法：在BB组（n = 11个鼻窦）和3DPHA-PCL组（n = 11个鼻窦）两个中心随机进行两种骨替代材料的侧位MSFE。在两个中心的21名参与者中进行了两种骨替代材料的横向MSFE，共分析了22个鼻窦。随机分为两组：BB组（11个）和3DPHA-PCL组（11个）。分别在术前（T0）、术后（T1）、术后6个月（T2）和术后1年（T3）进行锥形束ct检查。利用连续CBCT扫描分析增强体的尺寸稳定性。植入时进行骨芯活检，随后进行显微计算机断层扫描（micro-CT）和组织形态学分析。结果：T1与T2之间的CBCT叠加图像显示，两组患者的增高高度和体积均有所下降（BB组为-0.48±1.01 mm, -53.9±117.8 mm3, 3DPHA-PCL组为-0.39±0.44 mm, -40.8±101.2 mm3, p > 0.05），但组间差异无统计学意义。3DPHA-PCL组新生成骨百分率（组织形态学为15.7±7.5%，显微ct为16.7±7.5%）低于BB组（25.6±7.2%，显微ct为26.3±4.1%）(p)。结论：两组间增强骨的尺寸稳定性相当。然而，与BB组相比，3DPHA-PCL组的新骨形成和种植体存活率较低。需要长期随访监测3DPHA-PCL的行为。
{"title":"Polycaprolactone Impregnated 3D Printed Nanohydroxyapatite for Sinus Augmentation: A Randomized Controlled Trial","authors":"Poommarin Thammanoonkul, Suwit Limpattamapanee, Faungchat Thammarakcharoen, Jintamai Suwanprateeb, Hyun-Chang Lim, Borvornwut Buranawat","doi":"10.1002/cre2.70237","DOIUrl":"10.1002/cre2.70237","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To compare the effect of polycaprolactone impregnated 3D printed nano-hydroxyapatite (3DPHA-PCL) with bovine bone substitute material (BB) in lateral maxillary sinus floor elevation (MSFE).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Lateral MSFE with two bone substitute materials was randomly performed in two centers: group BB (<i>n</i> = 11 sinuses) or group 3DPHA-PCL (<i>n</i> = 11 sinuses). Lateral MSFE with two bone substitute materials was performed on 21 participants across two centers, resulting in a total of 22 sinuses analyzed. The sinuses were randomly allocated into two groups: group BB (11 sinuses) and group 3DPHA-PCL (11 sinuses). Cone beam computed tomography (CBCT) was taken before (T0) and immediately after MSFE (T1), at 6 months (implant placement; T2), and 1 year (T3). Dimensional stability of the augmentation was analyzed using serial CBCT scans. At the time of implant placement, bone core biopsy was performed, followed by microcomputed tomographic (micro-CT) and histomorphometric analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Based on the superimposed CBCT images between T1 and T2, the augmented height and volume decreased in both groups without a statistically significant difference between the groups (−0.48 ± 1.01 mm, −53.9 ± 117.8 mm<sup>3</sup> in group BB vs. −0.39 ± 0.44 mm, −40.8 ± 101.2 mm<sup>3</sup> in group 3DPHA-PCL, <i>p</i> > 0.05). The percentage of newly formed bone was statistically significantly lower in group 3DPHA-PCL (15.7 ± 7.5% histomorphometrically, 16.7 ± 7.5% in micro-CT) than group BB (25.6 ± 7.2%, 26.3 ± 4.1%) (<i>p</i> < 0.05 in both methods). Two implants failed in the 3DPHA-PCL group, while no failures in the BB group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Dimensional stability of the augmented bone was comparable between the groups. However, group 3DPHA-PCL demonstrated inferior new bone formation and implant survival compared to group BB. Long-term follow-up is warranted to monitor the behavior of 3DPHA-PCL.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Epigenetic modifications such as DNA methylation play a crucial role in the regulation of gene expression in inflammatory diseases, including periodontitis. While previous studies have examined methylation changes during active disease or shortly after treatment, little is known about the epigenetic landscape of periodontal tissues that have remained clinically stable over the long term after Supportive Periodontal Therapy (SPT).
Methods
We collected gingival tissue samples from 40 individuals, including 20 with a history of periodontitis currently under long-term SPT and 20 periodontally healthy controls. DNA methylation levels of LINE-1 (a marker of global methylation) and inflammation-related genes COX-2 (PTGS2), IFN-γ (IFNG), and TNF-α (TNF) were analyzed using bisulfite pyrosequencing.
Results
The LINE-1 methylation percentage was significantly higher in the periodontitis group than in the healthy group (66.5% ± 2.0 vs. 63.9% ± 4.0; p = 0.03). However, this significance was lost after adjusting for age and gender. No significant differences were observed between groups for COX-2, IFN-γ, or TNF-α. Genomic context analysis using the Encyclopedia of DNA Elements annotations revealed that the CpG sites analyzed for PTGS2, IFNG, and TNF are in distal regulatory regions enriched with enhancer-like elements, histone modifications, and predicted NFKB1 binding motifs.
Conclusions
These findings suggest that LINE-1 methylation in clinically stable gingival tissues may reflect long-term epigenetic memory from previous chronic inflammation. Motif-level analysis highlighted potential regulatory input from NFKB1 at the three loci (PTGS2, IFNG, and TNF). Notably, no significant epigenetic differences were observed in the inflammation-related genes COX-2, IFN-γ, and TNF-α, suggesting that periodontal disease can be effectively treated and that certain inflammatory markers may return to levels comparable to those seen in individuals who have never had the disease. These results highlight the importance of examining DNA methylation dynamics not only during active disease but also during long-term remission.
{"title":"DNA Methylation of COX-2, IFN-γ, TNF-α, and LINE-1 in Clinically Stable Periodontal Tissues Following Periodontal Therapy","authors":"Giulio Rasperini, Koki Yoshida, Alessandro Martinotti, Valentina Bollati, Letizia Tarantini, Farah Asa'ad","doi":"10.1002/cre2.70229","DOIUrl":"10.1002/cre2.70229","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Epigenetic modifications such as DNA methylation play a crucial role in the regulation of gene expression in inflammatory diseases, including periodontitis. While previous studies have examined methylation changes during active disease or shortly after treatment, little is known about the epigenetic landscape of periodontal tissues that have remained clinically stable over the long term after Supportive Periodontal Therapy (SPT).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We collected gingival tissue samples from 40 individuals, including 20 with a history of periodontitis currently under long-term SPT and 20 periodontally healthy controls. DNA methylation levels of LINE-1 (a marker of global methylation) and inflammation-related genes <i>COX-2</i> (<i>PTGS2</i>), <i>IFN-γ</i> (<i>IFNG</i>), and <i>TNF-α</i> (<i>TNF</i>) were analyzed using bisulfite pyrosequencing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The LINE-1 methylation percentage was significantly higher in the periodontitis group than in the healthy group (66.5% ± 2.0 vs. 63.9% ± 4.0; <i>p</i> = 0.03). However, this significance was lost after adjusting for age and gender. No significant differences were observed between groups for <i>COX-2</i>, <i>IFN-γ</i>, or <i>TNF-α</i>. Genomic context analysis using the Encyclopedia of DNA Elements annotations revealed that the CpG sites analyzed for <i>PTGS2</i>, <i>IFNG</i>, and <i>TNF</i> are in distal regulatory regions enriched with enhancer-like elements, histone modifications, and predicted <i>NFKB1</i> binding motifs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings suggest that LINE-1 methylation in clinically stable gingival tissues may reflect long-term epigenetic memory from previous chronic inflammation. Motif-level analysis highlighted potential regulatory input from <i>NFKB1</i> at the three loci (<i>PTGS2</i>, <i>IFNG</i>, and <i>TNF</i>). Notably, no significant epigenetic differences were observed in the inflammation-related genes <i>COX-2</i>, <i>IFN-γ</i>, and <i>TNF-α</i>, suggesting that periodontal disease can be effectively treated and that certain inflammatory markers may return to levels comparable to those seen in individuals who have never had the disease. These results highlight the importance of examining DNA methylation dynamics not only during active disease but also during long-term remission.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Early childhood caries (ECC) is a public health challenge, leading to long-term dental problems and costs. Limited access to preventive care underscores the need for innovative screening methods. Tele-dentistry, using smartphone-based imaging, offers a scalable solution for ECC detection and intervention.
Objective
This study evaluates the accuracy of maternal smartphone-based ECC assessments compared to professional evaluations as a reliable screening tool.
Methods
A cross-sectional-study recruited 114 mother–child pairs from primary healthcare centers in Tehran province, Iran. Mothers received online training and conducted visual and smartphone-based caries assessments. Two blinded pediatric dentists remotely reviewed images, with findings compared to in-person dental examinations. Sensitivity, specificity, and intraclass correlation coefficients (ICCs) were calculated.
Results
The mean child age was 4.8 ± 0.9 years with 56.1% boys and 43.9% girls. Mothers had a mean age of 33.2 ± 5.6 years with 55% having a high school diploma or higher. Maternal assessments identified caries in 49/58 cases (84.5%), while pediatric dentists detected 51/58 cases (87.9%). Maternal assessments showed 100% sensitivity and specificity, with strong agreement with professional evaluations (ICC = 0.909–0.988, p < 0.0001). The three methods demonstrated near-perfect concordance (ICC = 0.978, p < 0.0001).
Conclusion
Maternal-assisted tele-dentistry is a reliable, accessible screening method for ECC, improving early intervention, especially in low resources settings and underserved communities.
{"title":"Evaluating Maternal Accuracy in Smartphone-Based Tele-Dentistry for Early Childhood Caries Detection","authors":"Parastoo Iranparvar, Zahra Ghorbani, Sajjad Zandieh, Serlie Hartoonian, Mohsen Shirazi","doi":"10.1002/cre2.70231","DOIUrl":"10.1002/cre2.70231","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Early childhood caries (ECC) is a public health challenge, leading to long-term dental problems and costs. Limited access to preventive care underscores the need for innovative screening methods. Tele-dentistry, using smartphone-based imaging, offers a scalable solution for ECC detection and intervention.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study evaluates the accuracy of maternal smartphone-based ECC assessments compared to professional evaluations as a reliable screening tool.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional-study recruited 114 mother–child pairs from primary healthcare centers in Tehran province, Iran. Mothers received online training and conducted visual and smartphone-based caries assessments. Two blinded pediatric dentists remotely reviewed images, with findings compared to in-person dental examinations. Sensitivity, specificity, and intraclass correlation coefficients (ICCs) were calculated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean child age was 4.8 ± 0.9 years with 56.1% boys and 43.9% girls. Mothers had a mean age of 33.2 ± 5.6 years with 55% having a high school diploma or higher. Maternal assessments identified caries in 49/58 cases (84.5%), while pediatric dentists detected 51/58 cases (87.9%). Maternal assessments showed 100% sensitivity and specificity, with strong agreement with professional evaluations (ICC = 0.909–0.988, <i>p</i> < 0.0001). The three methods demonstrated near-perfect concordance (ICC = 0.978, <i>p</i> < 0.0001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Maternal-assisted tele-dentistry is a reliable, accessible screening method for ECC, improving early intervention, especially in low resources settings and underserved communities.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70231","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sadeq A. Al-Maweri, Gamilah Al-Qadhi, Ahmed Yaseen Alqutaibi, Nadhem M. Sallam, Mounzer Assad, Mahfoudh A. Abdulghani, Marwan Mansoor Ali Mohammed
Objectives
The management of oral lichen planus (OLP) is challenging, with no definitive cure available. This systematic review and meta-analysis aimed to assess the efficacy of curcumin in managing OLP.
Material and Methods
A comprehensive search of PubMed, Scopus, Web of Science, and Google Scholar was conducted for relevant clinical trials published up to March 31, 2025. All clinical trials comparing the efficacy of curcumin to corticosteroids were included. A meta-analysis was conducted on studies with available numerical data to assess the efficacy of curcumin relative to the control group.
Results
Eleven clinical trials, involving 499 OLP patients, were included in this review, with nine studies were incorporated into the meta-analysis. All studies reported curcumin to be efficacious in alleviating the signs and symptoms of OLP. Pooled data showed significantly better efficacy of curcumin in reducing pain at 1 week (SMD, −0.70; 95% CI, −1.33, −0.07; p = 0.03; I2 = 66%) compared with corticosteroids. However, no significant differences were observed between the two groups at the 2-, 4-, and 12-week follow-ups. Additionally, curcumin and corticosteroids demonstrated comparable efficacy in clinical improvement of lesions across different time points.
Conclusions
The available evidence suggests that curcumin has promising effects in managing OLP. However, due to methodological limitations, including significant heterogeneity among the studies and a high risk of bias in most of them, further well-designed studies with adequate follow-up periods are needed.
目的口腔扁平苔藓（OLP）的治疗具有挑战性，目前尚无明确的治疗方法。本系统综述和荟萃分析旨在评估姜黄素治疗OLP的疗效。材料与方法综合检索PubMed、Scopus、Web of Science、谷歌Scholar，检索截止2025年3月31日已发表的相关临床试验。所有比较姜黄素与皮质类固醇疗效的临床试验均被纳入。一项荟萃分析对研究进行了可用的数值数据，以评估姜黄素相对于对照组的疗效。结果本综述纳入了11项临床试验，涉及499例OLP患者，其中9项研究纳入meta分析。所有研究都报道姜黄素对缓解OLP的症状和体征有效。综合数据显示，姜黄素在1周时减轻疼痛的疗效明显优于皮质类固醇（SMD, - 0.70; 95% CI, - 1.33, - 0.07; p = 0.03; I2 = 66%）。然而，在2周、4周和12周的随访中，两组之间没有观察到显著差异。此外，姜黄素和皮质类固醇在不同时间点病变的临床改善方面表现出相当的疗效。结论姜黄素对OLP有较好的治疗作用。然而，由于方法学的局限性，包括研究之间的显著异质性和大多数研究的高偏倚风险，需要进一步精心设计的研究和足够的随访期。
{"title":"Curcumin Versus Corticosteroids for Symptomatic Oral Lichen Planus: A Systematic Review and Meta-Analysis","authors":"Sadeq A. Al-Maweri, Gamilah Al-Qadhi, Ahmed Yaseen Alqutaibi, Nadhem M. Sallam, Mounzer Assad, Mahfoudh A. Abdulghani, Marwan Mansoor Ali Mohammed","doi":"10.1002/cre2.70227","DOIUrl":"https://doi.org/10.1002/cre2.70227","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The management of oral lichen planus (OLP) is challenging, with no definitive cure available. This systematic review and meta-analysis aimed to assess the efficacy of curcumin in managing OLP.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>A comprehensive search of PubMed, Scopus, Web of Science, and Google Scholar was conducted for relevant clinical trials published up to March 31, 2025. All clinical trials comparing the efficacy of curcumin to corticosteroids were included. A meta-analysis was conducted on studies with available numerical data to assess the efficacy of curcumin relative to the control group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Eleven clinical trials, involving 499 OLP patients, were included in this review, with nine studies were incorporated into the meta-analysis. All studies reported curcumin to be efficacious in alleviating the signs and symptoms of OLP. Pooled data showed significantly better efficacy of curcumin in reducing pain at 1 week (SMD, −0.70; 95% CI, −1.33, −0.07; <i>p</i> = 0.03; <i>I</i><sup>2</sup> = 66%) compared with corticosteroids. However, no significant differences were observed between the two groups at the 2-, 4-, and 12-week follow-ups. Additionally, curcumin and corticosteroids demonstrated comparable efficacy in clinical improvement of lesions across different time points.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The available evidence suggests that curcumin has promising effects in managing OLP. However, due to methodological limitations, including significant heterogeneity among the studies and a high risk of bias in most of them, further well-designed studies with adequate follow-up periods are needed.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70227","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145110729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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