Clinical and Experimental Dental Research最新文献

{"title":"The Impact of Antioxidant Adjuncts on Periodontal Health in Type 2 Diabetes Patients: A Meta-Analysis","authors":"Sara A. Abdulla,&nbsp;Bushra A. Abdalla,&nbsp;Aisha Ali Muhammed,&nbsp;Hayam A. Elawamy,&nbsp;Salima M. Hawda,&nbsp;Najah Mohamed,&nbsp;Enass H. Abduallah,&nbsp;Mustafa Y. G. Younis,&nbsp;Hajir Omar Alsanfaz,&nbsp;Hiba Abdelmunim Suliman","doi":"10.1002/cre2.70215","DOIUrl":"10.1002/cre2.70215","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The bidirectional relationship between periodontitis and type 2 diabetes (T2D) underscores the need for adjunctive therapies to enhance nonsurgical periodontal therapy (NSPT). This meta-analysis evaluates the efficacy of antioxidants in improving periodontal and glycemic outcomes in T2D patients with periodontitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>A systematic literature search was conducted using PubMed, Embase, Scopus, Web of Science, and Google Scholar, covering publications from 2015 to 2025. Antioxidants tested were melatonin, propolis, lycopene, ginger, vitamin C, omega-3 fatty acids (O3FAs), and grape seed extract. Outcomes (clinical attachment level [CAL], probing depth [PD], gingival index [GI], HbA1c) were analyzed using random-effects models (mean differences, 95% CIs). Risk of bias was assessed via the Cochrane criteria.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Eight randomized controlled trials (RCTs, <i>n</i> = 315) were identified. Adjunctive antioxidants significantly improved CAL (melatonin: SMD −2.28, 95% CI −3.01 to −1.56; propolis: SMD −3.83, −4.79 to −2.87) and PD (melatonin: SMD −2.40, −3.14 to −1.66; propolis: SMD −1.78, −2.44 to −1.11). Melatonin and propolis also reduced HbA1c (melatonin: SMD −2.28; propolis: SMD −3.83). Lycopene and ginger showed modest effects, while vitamin C and O3FAs had minimal impact. Evidence certainty was moderate for CAL/HbA1c and low for PD/GI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Antioxidants, particularly melatonin and propolis, enhance periodontal and glycemic outcomes in T2D-periodontitis patients. Despite promising results, limitations include small sample sizes and heterogeneity. Larger RCTs are needed to optimize protocols.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70215","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145387628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of Discoloration of Anterior Teeth With Three Types of Substances Used in Endodontic Treatment","authors":"Sahar Soltani,&nbsp;Eshagh Ali Saberi,&nbsp;Nazanin Shahradnia,&nbsp;Pedram Abdollahzade Sangrodi,&nbsp;Elham Majidi","doi":"10.1002/cre2.70204","DOIUrl":"10.1002/cre2.70204","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aims to investigate the discoloration of anterior teeth with three types of substances used in endodontic treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>In this laboratory study, 75 newly extracted human anterior (central and lateral) teeth with full roots were examined. This study utilized the following materials: AH26, MTA Base (Maruchi), a novel formulation containing nano-zinc particles, and a second novel formulation containing both nano-zinc and nano-copper particles. The teeth in the first three groups were dried with paper points, and the canals were completely sealed using the sealer lateral filling technique with gutta-percha. Then the color of the samples was measured by a spectrophotometer at four times: initially, immediately after filling (0), 14 days, and 28 days later.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results showed that the mean color change (∆E) at all times (immediately, 14 days later, and 28 days later) was statistically significant between all groups (<i>p</i> &lt; 0.05). The degree of color change decreased in the following order: AH26 &gt; Zn-nano &gt; Zn.Cu-nano &gt; novel nano-zinc/copper material &gt; MTA Base (Maruchi) &gt; control group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The results of the present study showed that sealers with a zinc base (Zn-nano and Zn.Cu-nanoparticles) had an appropriate color change. Therefore, they can be used alongside other sealers available in the market.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70204","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145387620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventive and Therapeutic Effects of Plant-Derived Compounds on Tooth Erosion: A Systematic Review and Meta-Analysis of In Situ and In Vitro Studies","authors":"Mahtab Memarpour,&nbsp;Neda Afzali Baghdadabadi,&nbsp;Golnoush Farzinnia,&nbsp;Mahya Agharokh,&nbsp;Niloofar Mokhtari,&nbsp;Erfan Bardideh","doi":"10.1002/cre2.70235","DOIUrl":"10.1002/cre2.70235","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Tooth erosion is the nonbacterial and irreversible pathological dissolution of enamel and dentin, and is primarily influenced by lifestyle. This systematic review and meta-analysis aimed to evaluate the preventive and therapeutic effects of plant-derived compounds on tooth erosion using evidence from <i>in vitro</i> and <i>in situ</i> studies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>The review was registered in PROSPERO (CRD42023493906) and search was performed in PubMed, Scopus, ISI Web of Science, and Embase databases until July 5, 2025. <i>In vitro</i> and <i>in situ</i> original studies that investigated the effects of plant-based interventions on dental erosion, with a control group, were included. <i>In vivo</i> studies and those plants combined with non-plant substances were excluded. Risk of bias was assessed using the QUIN tool. Meta-analyses were performed when appropriate. Mechanical and ultrastructure assessments used to evaluate surface loss, hardness, and morphological changes were also reviewed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Out of 1119 studies, 38 studies met the inclusion criteria; 22 studies assessed preventive effects, and 18 assessed the therapeutic effects, and one study that evaluated both the effects. Most studies had a medium risk of bias. Meta-analysis showed that quercetin as a preventive measure, significantly reduced dentin loss by 4.95 µm with high heterogeneity (<i>I</i>² = 98%). For therapeutic measures, green tea reduced dentin loss by 0.89 µm, whereas epigallocatechin-3-gallate (EGCG) did not significantly decrease dentin loss. The two analyses were heterogeneous (<i>I</i>² = 99%). Quercetin significantly decreased dentin loss by 4.19 µm with low heterogeneity (<i>I</i>² = 0%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Plants with polyphenols may modify the pellicle layer ultrastructure to protect teeth from erosion. Quercetin (the most common flavonoid in fruit and vegetables) has preventive and therapeutic effects on dentin erosion. Green tea (because of its elevated catechin content) has therapeutic effects on dentin erosion.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12560117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145376594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Cleaning Methods for Resilient Denture Liners: A Three-Period Randomized Crossover Trial","authors":"Rihoko Takeuchi,&nbsp;Shin Miyamae,&nbsp;Nana Sonobe,&nbsp;Humika Hattori,&nbsp;Yuei Morinaga,&nbsp;Hisato Hotta,&nbsp;Yoshiaki Hasegawa,&nbsp;Suguru Kimoto","doi":"10.1002/cre2.70243","DOIUrl":"10.1002/cre2.70243","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Several studies have demonstrated that insufficient denture hygiene constitutes a significant risk factor for aspiration pneumonia. While various cleaning protocols have been proposed for conventional hard denture base materials, there remains a notable paucity of research specifically addressing effective cleaning strategies for resilient denture liners (RDLs). This study aimed to evaluate the efficacy of three denture cleaning methods—mechanical, chemical, and dual (combined mechanical and chemical)—for removing microbial biofilms from different denture-liner materials using a randomized crossover clinical trial.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This three-period randomized crossover clinical trial included edentulous patients wearing maxillary complete dentures embedded with specimens of a hard-resin liner and silicone-based and acrylic-based RDLs. All liners were fabricated directly in the patient's mouth. Participants performed the three cleaning interventions for 2 weeks each. Swabs from the relined denture surfaces were cultured in phosphate-buffered saline, and the colony-forming units (CFUs) were counted. The influence of each cleaning method on the CFU count was determined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The dual-cleaning method demonstrated a significant reduction in CFU count compared to mechanical cleaning, but only for the acrylic-based RDL. No significant differences were observed between the cleaning methods for the silicone-based RDL and hard-resin liner. The CFU count was the highest for silicone-based RDLs, followed by that for acrylic-based RDLs, and hard-resin liners.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The dual method comprising mechanical and chemical cleaning was the most effective cleaning strategy for relined dentures, although the advantage was limited to acrylic-based RDL.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>This study was registered in the UMIN Clinical Trials Registry (UMIN000056738).</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70243","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145312352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Deep Convolutional Neural Network Models for the Classification of Benign Fibro-Osseous Lesions of the Jaws","authors":"Paniti Achararit,&nbsp;Chawan Manaspon,&nbsp;Chavin Jongwannasiri,&nbsp;Kraisorn Sappayatosok,&nbsp;Thanaphum Osathanon,&nbsp;Ekarat Phattarataratip","doi":"10.1002/cre2.70244","DOIUrl":"https://doi.org/10.1002/cre2.70244","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Benign fibro-osseous lesions (BFOL) constitute a group of pathologic entities with marked overlapping histopathologic features but are diverse in nature and clinical behaviors. Accurate diagnoses of BFOLs necessitate clinical-pathological correlations, which are paramount for their appropriate management. Recent research indicates the potential utility of artificial intelligence in diagnostic pathology. Here, we aimed to assess the performance of the deep convolutional neural network (DCNN) models for BFOL classification and investigate its impact on the diagnostic performance of oral pathologists.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Microscopic slides from 68 patients diagnosed with cemento-ossifying fibroma (COF), fibrous dysplasia (FD), and cemento-osseous dysplasia (COD) were collected. The image patches from each slide were processed, augmented, and used to train and validate the five pre-trained DCNN models for BFOL classification. The best-performing model was selected to evaluate its diagnostic performance on the testing data set, compared with experienced oral pathologists.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The InceptionV3 model showed the highest and most balanced overall performance in BFOL classification. It demonstrated the highest accuracy (96.7%) in classifying COF, followed by COD (83.3%), and FD (80.0%), respectively. The model accuracy in identifying COF was greater than the average performance of pathologists (90.0%). However, pathologists performed better in classifying COD (87.2%) and FD (95.0%). With DCNN assistance, pathologists significantly improved the accuracy, sensitivity, and specificity in distinguishing BFOLs while reducing the average diagnosis time.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The DCNN model has the potential to be developed as an auxiliary tool, assisting pathologists in diagnosing BFOLs. Through ongoing refinements, artificial intelligence assistance can aid pathologists in enhancing the accuracy and efficiency of BFOL diagnosis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70244","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145297282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peri-Implantitis and Survival Outcomes of Tissue Level Versus Bone Level Dental Implants: A Systematic Review and Meta-Analysis","authors":"Momen A. Atieh,&nbsp;Maanas Shah,&nbsp;Abeer Hakam,&nbsp;Ahmad Aid,&nbsp;Andrew Tawse-Smith,&nbsp;Nabeel H. M. Alsabeeha","doi":"10.1002/cre2.70242","DOIUrl":"10.1002/cre2.70242","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The aim of this systematic review and meta-analyses was to evaluate the outcomes of using tissue level in comparison to bone level implants in terms of clinical and radiographic changes, peri-implantitis, and implant failure rates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Electronic databases were searched to identify randomized studies that compared tissue level to bone level implant. The risk of bias was assessed using the Cochrane Collaboration's Risk of Bias tool. Data were analyzed using a statistical software program.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 798 studies were identified, of which, five studies with 501 dental implants in 241 participants were included. Overall meta-analysis showed that the use of tissue level implants had lower rates of peri-implantitis (relative risk [RR] 0.59; 95% confidence interval [CI] 0.14–2.48; <i>p</i> = 0.47) and implant failure (RR 0.59; 95% CI 0.07–4.69; <i>p</i> = 0.62) but the differences were not statistically significant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Tissue level and bone level have comparable survival rates and risk of peri-implantitis within 1–5 years of observation. Additionally, no significant differences in probing pocket depths and marginal bone level changes were observed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Clinical Relevance</h3>\u0000 \u0000 <p>Tissue level implants demonstrated lower rates of peri-implantitis and implant failure, as well as smaller changes in probing pocket depths at 12 and 24 months, compared to bone level implants. Although these differences were not statistically significant, they suggest potential clinical advantages of tissue level implants in maintaining peri-implant health and stability over time.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12529224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145299066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Link Between Social Capital and Edentulism in Low- and Middle-Income Countries","authors":"Saida Ben-Bihi,&nbsp;Yanfei Guo,&nbsp;Richard Olofsson,&nbsp;Hülya Çevik-Aras,&nbsp;Junmei Miao Jonasson","doi":"10.1002/cre2.70241","DOIUrl":"10.1002/cre2.70241","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Although social capital (SC) has received growing attention in public health, no research has yet compared how SC and oral health are associated in diverse contexts. This cross-sectional study aims to examine the association of community and individual-level SC with edentulism among adults aged 50 and above in five low- and middle-income countries (LMICs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Data are from SAGE-wave 1 (2007–2010), including 27,676 participants aged 50 years or older from China (<i>N</i> = 12,830), Ghana (<i>N</i> = 4261), India (<i>N</i> = 6040), Mexico (<i>N</i> = 1327), and South Africa (<i>N</i> = 3218). The primary outcome was self-reported edentulism. Cognitive and structural SC were used to measure SC at the individual and community levels. The association between SC dimensions and oral health was investigated using a two-level multilevel logistic regression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Multilevel analysis revealed that low individual and community structural SC are independently associated with edentulism in China (OR 1.43; CI 1.08–1.89 and OR 1.95; CI 1.32–2.90, respectively). In South Africa, low individual cognitive SC was negatively associated with edentulism (OR 0.48; CI 0.24–0.98), while low individual structural SC was positively associated with edentulism (OR 2.34; CI 1.16–4.74). In Ghana, only participants living in middle community structural SC had higher odds of being edentulous after adjustment for all potential confounders (OR 1.78; CI 0.71–2.96). In Mexico and India, no association was found between any dimensions of SC and oral health.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The dimensions of SC and its relationship to edentulism differed across the five LMICs. Our study highlights the importance of considering contextual factors when analyzing the relationship between SC and oral health. Further research is required to understand how SC influences oral health in LMICs.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12519621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Endodontic Treatment in Far North Queensland, Australia: A Retrospective Observational Study of 11 Years","authors":"Aditya Suvarna,&nbsp;Preethi Thennarasu,&nbsp;Sona Sojan,&nbsp;Olivia Gables,&nbsp;Daniel J. Browne,&nbsp;Rodrigo R. Amaral","doi":"10.1002/cre2.70232","DOIUrl":"10.1002/cre2.70232","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This retrospective observational study assessed demographics, geographical influences, and diagnostic trends in patients receiving endodontic treatment at James Cook University dental clinics between 2011 and 2022. Patient demographics (sex and age), treatment timing, and care types were examined, with a focus on regional and rural disparities in access to endodontic care.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Data were extracted from electronic dental records from 2011 to 2022 using service item codes under the “Endodontics section (codes 411–459)” of the Australian Schedule of Dental Services and Glossary. The Modified Monash Model framework was used to assess geographical disparities in treatment access.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Females sought treatment earlier than males, who often presented later with more severe symptoms. Older males were more likely to present with pulpal necrosis and chronic apical abscesses, whereas females had higher rates of previously initiated endodontic therapy and asymptomatic apical periodontitis. A total of 2932 patients were treated, with tooth 46 being the most treated (7.54%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Significant geographical disparities in endodontic treatment timing exist, with rural and remote patients experiencing delays in treatment. These findings highlight the need for improved access to specialized dental care, particularly in underserved areas.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12519619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Palatally Displaced Canines in Children: A Randomized Controlled Pilot Trial on Exposure Time and Patient Perception of Two Closed Surgical Methods","authors":"Katja Hashemi Elses,&nbsp;Krister Bjerklin,&nbsp;Ann-Marie Roos Jansåker,&nbsp;Mikael Sonesson","doi":"10.1002/cre2.70233","DOIUrl":"10.1002/cre2.70233","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate treatment time and patient perception of two surgical methods to expose a palatally displaced canine (PDC) into the oral cavity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>A total of 30 consecutive patients between 11 and 18 years, with maxillary displaced canines were recruited. After gaining informed consent from the patients and custodians, the patients were randomized into two groups by an independent person. Both groups received a chain attached to the crown of the canine: in group A (control group) the chain was placed under the mucoperiosteal flap to an incision on the alveolar crest and in group B (test group), the chain penetrated the mucoperiosteal flap inferiorly to the crown of the canine. Outcome measures where time to expose the PDC into the oral cavity and the patient's experience of pain and discomfort during the treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty-six patients full-filled the trial, mean age was 12.9 years, (SD 1.6 years). The time to expose the canines for the control group was 11.9 months (SD 6.5) and for the test group 6.7 months (SD 3.2) The conventional method showed less pain on the day of surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The method used in the test group resulted in a 5-month shorter time to expose the canine compared to the control group, and higher pain level on the day of surgery. For generalizability of the results, larger studies are needed.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12516783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145279034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Does the Bonding Strength of Reline Materials and Denture Teeth Vary Between 3D-Printed and Milled Complete Denture Bases? A Systematic Review and Meta-Analysis","authors":"Sarah Arzani,&nbsp;Erfan Khorasani,&nbsp;Aida Mokhlesi,&nbsp;Shima Azadian,&nbsp;Safoura Ghodsi,&nbsp;Seyed Ali Mosaddad","doi":"10.1002/cre2.70234","DOIUrl":"10.1002/cre2.70234","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To systematically compare the bond strength of denture teeth and reline materials to additively manufactured (AM) versus subtractively milled (SM) denture base resins and to identify the material- and process-related factors influencing bonding performance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A systematic electronic search of PubMed, Scopus, Embase, Web of Science, the Cochrane Library, and Google Scholar was conducted up to December 10, 2024. Eligible in vitro studies comparing bond strength at either the tooth–base or reline–base interface using AM and SM denture bases were included. Studies that lacked direct comparison, involved conventional heat-polymerized bases, or did not report quantitative bond strength data were excluded. Meta-analyses were performed using random-effects models, calculating mean differences (MD) for tooth bonding and standardized mean differences (SMD) for reline bonding. Subgroup, sensitivity, and publication bias analyses (Egger's regression and Begg's rank tests) were included. Risk of bias was evaluated using QUIN tools.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Out of 2985 screened records, 20 studies comprising 156 independent comparisons were included; 41 for tooth bonding and 115 for reline bonding. Initial tooth-bonding meta-analysis revealed no significant difference; however, after exclusion of two outlier comparisons identified through sensitivity analysis (<i>n</i> = 39), milled bases demonstrated significantly higher bond strength (MD = −2.43 MPa, 95% CI–3.90 to −0.96; <i>p</i> = 0.001). For reline bonding, AM bases consistently underperformed across all studies, with the pooled estimate favoring milled bases (SMD = −2.62, 95% CI–3.22 to −2.03; <i>p</i> = 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Within the limitations of this review, milled denture bases demonstrate consistently stronger and more reliable bonding to both teeth and reline materials than current printable photopolymer bases.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}