Clinical and Experimental Dental Research最新文献_第3页

Education and Communication on the Topic of Osteonecrosis of the Jaw When Taking Bone-Stabilizing Drugs 关于服用骨稳定药物时颌骨坏死主题的教育和交流。

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research

Pub Date : 2024-11-04 DOI: 10.1002/cre2.70024

Franz Gustav Saur, Christian Keinki, Alin Cramer, Jens Buentzel, Jutta Hübner

Objectives

The aim of this study was to analyze the communication between doctors and patients who were taking bone-stabilizing medication and in rare cases developed osteonecrosis of the jaw as a result.

Material and Methods

A standardized questionnaire recorded deficits based on patient experiences. These data were used to develop solution strategies for improving doctor–patient communication and the benefit–risk assessment of medication use.

Results

Most patients were satisfied with the information provided by their doctor; however, one in three (29.8%) were not informed about possible side effects, and a quarter (24.6%) only found out about osteonecrosis of the jaw through their own research. Only half (45.7%) were asked about risk factors, and most information materials were rated poorly. The diagnosis took an average of 18.7 months, with many (47.8%) consulting a doctor only when they experienced pain. Quality of life was severely impaired, with daily pain, physical limitations, and negative effects on mental health. About a third (35.3%) reported that their quality of life had deteriorated significantly.

Conclusions

Further research into patient education is necessary. Web-based information brochures, improved follow-up care, and close cooperation with dentists are required. The use of a running sheet, such as the AGSMO running sheet, for individual risk assessment of osteonecrosis of the jaw is recommended. Patients undergoing treatment with bone-stabilizing medication should be monitored closely. Education about osteonecrosis of the jaw must be continued, and the medical profession must be confronted with it.

研究目的本研究的目的是分析医生与服用骨稳定药物的患者之间的沟通情况，在极少数情况下，患者会因此患上颌骨坏死：一份标准化问卷记录了基于患者经验的缺陷。结果：大多数患者对所提供的信息表示满意：大多数患者对医生提供的信息表示满意；然而，三分之一（29.8%）的患者未被告知可能出现的副作用，四分之一（24.6%）的患者仅通过自己的调查了解到颌骨坏死。只有一半（45.7%）的人被问及风险因素，大多数信息资料的评分都很低。诊断平均需要18.7个月，许多人（47.8%）只有在出现疼痛时才去看医生。他们的生活质量受到严重影响，每天都感到疼痛，身体受到限制，心理健康也受到负面影响。约有三分之一（35.3%）的患者表示他们的生活质量严重下降：结论：有必要对患者教育开展进一步研究。结论：有必要对患者教育进行进一步研究，需要制作基于网络的信息手册，改善后续护理，并与牙医密切合作。建议使用诸如 AGSMO 的流水单对颌骨坏死进行个体风险评估。对接受骨稳定药物治疗的患者应进行密切监测。必须继续开展有关颌骨坏死的教育，并使医学界正视这一问题。

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引用次数: 0

Does Fusobacterium in Colorectal Cancer Sites Originate From the Oral Cavity? A Pilot Study 大肠癌病灶中的镰刀菌是否来自口腔？一项试点研究。

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research

Pub Date : 2024-11-03 DOI: 10.1002/cre2.70016

Niels Plomp, Kristina Bertl, Marie-Louise Lydrup, Klas Sjöberg, Hermie J. M. Harmsen, Andreas Stavropoulos

Objectives

Fusobacterium can contribute to oral diseases, but also pose as a systemic risk factor. This genus, and especially F. nucleatum, can be found in colorectal cancer (CRC) tissue and is involved in multiple aspects of this type of cancer. Previous studies indicated a possible oral origin of these bacteria; however, stronger evidence is needed to reach a definitive conclusion. This pilot study aimed to establish a method to successfully compare, at the strain level, fusobacteria from the oral cavity and CRC resection material for future cohort studies of CRC patients.

Material and Methods

In a first cohort of eight periodontitis patients, gingival crevicular fluid and saliva were collected. Fusobacterium was isolated on two different media. In a second cohort, saliva and CRC resection material were collected from ten CRC patients. These samples were used for screening of Fusobacterium with culturing, 16S rRNA gene profiling and a PCR-based approach.

Results

In the first cohort, different Fusobacterium species were identified in GCF and saliva samples. However, as the total yield of Fusobacterium seemed slightly higher in saliva samples, it was therefore preferred for subsequent sample collection. Thus, in the second cohort, patient-matched saliva and CRC resection material were screened for Fusobacterium and this showed that nine patients were culture-positive in the saliva samples; however, no Fusobacterium could be isolated from the resection material. On the other hand, 16S rRNA gene profiling of the resection material indicated that eight CRC patients were positive for Fusobacterium. All eight of these patients carried Fusobacterium in their saliva, indicated by both marker gene PCR and culture-based screening.

Conclusions

These pilot results are compatible with data from previous studies, indicating a possible link between oral and CRC-associated Fusobacterium, and a more in-depth analysis of specific strains and their characteristics in a larger cohort is justified.

Trial Registration

The protocol was registered at clinicaltrials.gov (NCT05945082).

目的：镰刀菌可导致口腔疾病，但也是一种全身性风险因素。在结肠直肠癌（CRC）组织中可发现该菌属，尤其是核酸镰刀菌，并与此类癌症的多个方面有关。以前的研究表明，这些细菌可能来源于口腔，但要得出确切的结论还需要更有力的证据。这项试验性研究旨在建立一种方法，成功地在菌株水平上比较口腔和 CRC 切除材料中的镰刀菌，以便将来对 CRC 患者进行队列研究：材料：在第一批 8 名牙周炎患者中收集了牙龈缝隙液和唾液。在两种不同的培养基上分离出镰刀菌。在第二组样本中，收集了 10 名乳腺癌患者的唾液和乳腺癌切除材料。通过培养、16S rRNA 基因图谱分析和基于 PCR 的方法对这些样本进行了镰刀菌筛选：结果：在第一组样本中，GCF 和唾液样本中发现了不同的镰刀菌种类。然而，由于唾液样本中的镰刀菌总产量似乎略高，因此在随后的样本采集中更倾向于唾液样本。因此，在第二个队列中，对与患者匹配的唾液和 CRC 切片材料进行了镰刀菌筛查，结果显示，9 名患者的唾液样本培养呈阳性；但从切除材料中无法分离出镰刀菌。另一方面，对切除材料进行的 16S rRNA 基因分析表明，8 名 CRC 患者的镰刀菌阳性。通过标记基因 PCR 和培养基筛查，这八名患者的唾液中均含有镰刀菌：这些试验结果与之前的研究数据相符，表明口腔和 CRC 相关镰刀菌之间可能存在联系，因此有必要在更大的群体中对特定菌株及其特征进行更深入的分析：试验方案已在 clinicaltrials.gov (NCT05945082) 上注册。

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引用次数: 0

Geriatric Oral Health and Quality of Life Among the Indigenous Irula Tribes of Tamil Nadu 泰米尔纳德邦土著伊鲁拉部落的老年口腔健康和生活质量。

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research

Pub Date : 2024-11-03 DOI: 10.1002/cre2.70036

Margret Beaula Alocious Sukumar, Alex Joseph, Baidaa Alhalabi

Objectives

This study aims to assess the oral health-related quality of life (OHRQoL) among the Irula tribes and to know the factors influencing quality of life among the elderly irula tribes of Tamil Nadu.

Methods

This cross-sectional study was conducted in the Northern district of Tamil Nadu, including 486 Irula individuals aged 65 and above. Participants were selected using a multistage sampling method. Data were collected through a structured questionnaire, including the Geriatric Oral Health Assessment Index (GOHAI) to evaluate OHRQoL. The study tool covered demographics, medical history, and oral health issues. Data analysis was performed using SPSS version 23, with logistic regression applied to account for confounders.

Results

The sample primarily consisted of individuals aged 65–69 years (55.6%), with a predominance of females (76.3%). The majority were Hindu (94.9%) and lived in nuclear families (88.3%). Educational levels were low, with 66.5% being illiterate. Most participants were agricultural laborers (64.6%) and had low monthly incomes. GOHAI results revealed that many respondents faced significant oral health challenges, including difficulties with eating, speaking, and discomfort. Multivariate analysis showed that educational level significantly affected OHRQoL, with higher education correlating with better quality of life. Arthritis was associated with poorer OHRQoL, while other health conditions did not show significant impacts.

Conclusion

The study highlights severe oral health issues among the Irula community, with significant physical and psychological impacts. Educational attainment plays a crucial role in OHRQoL, while arthritis notably affects quality of life. The findings emphasize the need for targeted oral health interventions and increased awareness in tribal communities to improve overall health outcomes. Further research in larger populations is necessary to comprehensively understand and address geriatric oral health needs.

研究目的本研究旨在评估伊鲁拉部落中与口腔健康相关的生活质量（OHRQoL），并了解影响泰米尔纳德邦伊鲁拉部落老年人生活质量的因素：这项横断面研究在泰米尔纳德邦北部地区进行，包括 486 名 65 岁及以上的伊鲁拉人。研究人员采用多阶段抽样法选出。通过结构化问卷收集数据，包括老年口腔健康评估指数 (GOHAI)，以评估口腔健康状况和生活质量。研究工具涵盖了人口统计学、病史和口腔健康问题。数据分析使用 SPSS 23 版进行，并采用逻辑回归来考虑混杂因素：样本主要由 65-69 岁的人组成（55.6%），女性占多数（76.3%）。大多数人信奉印度教（94.9%），生活在核心家庭中（88.3%）。受教育程度较低，66.5% 为文盲。大多数受访者是农业工人（64.6%），月收入较低。全球口腔健康状况调查（GOHAI）结果显示，许多受访者面临严重的口腔健康问题，包括进食困难、说话困难和不适。多变量分析表明，受教育程度对口腔健康生活质量有显著影响，受教育程度越高，生活质量越高。关节炎与较差的 OHRQoL 有关，而其他健康状况则没有明显影响：这项研究凸显了伊鲁拉社区严重的口腔健康问题，对身体和心理造成了重大影响。受教育程度在 OHRQoL 中起着至关重要的作用，而关节炎则对生活质量有明显影响。研究结果强调，有必要在部落社区采取有针对性的口腔健康干预措施，并提高人们的认识，以改善整体健康状况。有必要在更大的人群中开展进一步研究，以全面了解和满足老年人的口腔健康需求。

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引用次数: 0

Bibliometric Analysis of the 100 Most-Cited Articles on the Methods of Shade-Matching in Dentistry 关于牙科阴影匹配方法的 100 篇最常被引用文章的文献计量分析。

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research

Pub Date : 2024-11-03 DOI: 10.1002/cre2.70037

Farah Rashid, James Dudley

Objectives

The purpose of this bibliometric analysis is to identify the 100 most cited articles and delve into citation metrics to gain insights into the evolving trends in shade-matching methods in dentistry.

Material and Methods

Following PRISMA guidelines, two reviewers conducted a structured search in Scopus using keyword-based search strings. The top 100 articles were selected based on predefined criteria, and their bibliometric data were extracted. Harzing's Publish Or Perish and VOSviewer were used to generate the bibliographic network.

Results

Between 1989 and 2017, the top 100 articles were published and obtained citations ranging from 560 to 48. Twenty-eight articles received over 100 citations, deemed classic. The Journal of Prosthetic Dentistry and the United States of America were the primary contributors. In-vitro experimental studies employing restorative material samples were prevalent, with spectrophotometers being the favored method of color analysis. Using Python, Spearman's correlation coefficient resealed positive correlations between citation count and age of publication (r = 0.16, p = 0.12) and between citation count and the impact factor of the journal (r = 0.35, p < 0.05). However, a negative correlation was observed between citation density and age of publication (r = −0.46, p < 0.05).

Conclusions

This study demonstrated a significant upward trajectory of citation count in shade-matching in dentistry, reflecting high-quality scientific contributions.

目标：本文献计量学分析的目的是确定 100 篇被引用次数最多的文章，并深入研究引用指标，以深入了解牙科中阴影匹配方法的演变趋势：根据 PRISMA 指南，两位审稿人使用基于关键词的搜索字符串在 Scopus 中进行了结构化搜索。根据预先设定的标准选出前 100 篇文章，并提取其文献计量数据。使用 Harzing's Publish Or Perish 和 VOSviewer 生成文献网络：1989年至2017年期间，发表的前100篇文章获得的引用次数从560次到48次不等。28篇文章的引用次数超过100次，被视为经典之作。修复牙科杂志》和美国是主要贡献者。采用修复材料样本进行的体外实验研究非常普遍，分光光度计是最常用的颜色分析方法。通过使用 Python，斯皮尔曼相关系数显示引用次数与发表时间（r = 0.16，p = 0.12）以及引用次数与期刊影响因子（r = 0.35，p 结论）之间存在正相关：本研究表明，口腔医学中阴影匹配的引用次数呈显著上升趋势，反映了高质量的科学贡献。

{"title":"Bibliometric Analysis of the 100 Most-Cited Articles on the Methods of Shade-Matching in Dentistry","authors":"Farah Rashid, James Dudley","doi":"10.1002/cre2.70037","DOIUrl":"10.1002/cre2.70037","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The purpose of this bibliometric analysis is to identify the 100 most cited articles and delve into citation metrics to gain insights into the evolving trends in shade-matching methods in dentistry.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Following PRISMA guidelines, two reviewers conducted a structured search in Scopus using keyword-based search strings. The top 100 articles were selected based on predefined criteria, and their bibliometric data were extracted. <i>Harzing's Publish Or Perish</i> and <i>VOSviewer</i> were used to generate the bibliographic network.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Between 1989 and 2017, the top 100 articles were published and obtained citations ranging from 560 to 48. Twenty-eight articles received over 100 citations, deemed classic. The <i>Journal of Prosthetic Dentistry</i> and the United States of America were the primary contributors. In-vitro experimental studies employing restorative material samples were prevalent, with spectrophotometers being the favored method of color analysis. Using Python, Spearman's correlation coefficient resealed positive correlations between citation count and age of publication (<i>r</i> = 0.16, <i>p</i> = 0.12) and between citation count and the impact factor of the journal (<i>r</i> = 0.35, <i>p</i> < 0.05). However, a negative correlation was observed between citation density and age of publication (<i>r</i> = −0.46, <i>p</i> < 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study demonstrated a significant upward trajectory of citation count in shade-matching in dentistry, reflecting high-quality scientific contributions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"10 6","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Investigation Into Contaminated Waste Composition in a University Dental Clinic: Opportunities for Sustainability in Dentistry 大学牙科诊所污染废物成分调查：牙科可持续发展的机遇。

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research

Pub Date : 2024-10-29 DOI: 10.1002/cre2.70015

Samuel Yeoh, Yani Bourdamis, Adam Saker, Noah Marano, Liam Maundrell, Poornima Ramamurthy, Dileep Sharma

Objectives

Many international dental organizations have been advocating for sustainable practices in dentistry, whereby significant reductions in environmental impacts are needed. The aim of this study was to analyze dental clinical waste in a university clinic setting to explore opportunities for sustainable practices.

Material and Methods

Fifty dental units (chairs) that are routinely used in delivery of dental treatment and involved supervising clinicians, dental students, and patients were randomly selected, and the clinical waste generated was collected, segregated, and weighed. Statistical analysis was performed to analyze differences in waste production based on treatment performed.

Results

The mean waste production generated by each chair was 81.4 g of aprons, 56.2 g of gloves, 17.2 g of masks, 24.0 g of sterile wrappings, 48.8 g of other plastics, 100.8 g of cellulose-based items, and 25.8 g of miscellaneous items. Higher waste was generated from the chairs performing endodontic procedures when compared with examinations. A potential annual greenhouse gas saving of approximately 10 kg CO₂e per year (when one patient is treated daily) can be achieved if sterile wrapping plastics were to be recycled.

Conclusions

Simple yet achievable opportunities for efficient clinical waste management at university clinics exist, which in turn will increase environmental sustainability in the post-COVID-19 era. Increased awareness and incentives for sustainable measures could potentially enhance the possibility of wider adoption of ecofriendly approaches.

目的：许多国际牙科组织一直在倡导牙科的可持续实践，即需要大幅减少对环境的影响。本研究旨在分析一所大学诊所的牙科临床废物，以探索可持续实践的机会：随机抽取了 50 个牙科诊室（椅），这些诊室在提供牙科治疗时经常使用，涉及临床医生、牙科学生和患者，并对产生的临床废物进行了收集、分类和称重。进行了统计分析，以分析根据所进行的治疗而产生的废物量的差异：结果：每台牙科治疗椅产生的平均废物量为 81.4 克围裙、56.2 克手套、17.2 克口罩、24.0 克无菌包装材料、48.8 克其他塑料、100.8 克纤维素类物品和 25.8 克杂项物品。与检查相比，牙髓治疗椅产生的废物较多。如果对无菌包装塑料进行回收利用，每年可减少约 10 千克 CO2e 的温室气体排放（每天治疗一名患者）：结论：在大学诊所进行有效的临床废物管理存在着简单而可行的机会，这反过来又将提高后 COVID-19 时代的环境可持续性。提高对可持续发展措施的认识并采取激励措施，有可能促进更广泛地采用生态友好型方法。

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引用次数: 0

The Accuracy of the CBCT-Based 3-Dimensional Replica of the Donor Tooth in Autotransplantation 自体牙移植中基于 CBCT 的供体牙三维复制品的准确性。

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research

Pub Date : 2024-10-29 DOI: 10.1002/cre2.70032

Jessica Juslin, Tuija Teerijoki-Oksa, Päivi Jääsaari, Marja Ekholm, Pekka Vallittu, Lippo Lassila, Hanna Thorén

Background

This study evaluated the accuracy of the CBCT reconstruction model compared to the natural tooth and the accuracy of the replica tooth compared to the natural tooth.

Objective

The hypothesis was that a replica tooth could be used as a surgical guide in autotransplantation.

Methods

Three teeth were chosen and a CBCT reconstruction model was formed from each tooth. STL-data was transferred to a milling machine and replica teeth were milled from PEEK. A digitized surface model was prepared from the natural and the replica teeth by a stereophotogrammetry scanner. The surface model from the optical scan of the natural tooth was compared to the CBCT reconstruction model and the surface model of the replica tooth. The models were matched on each other, and surface-based rigid registration was performed between the surface models. Distances were calculated and visualized by MATLAB.

Results

The CBCT reconstruction model and the natural tooth were compared. The largest euclidean distance was found at the root tip in the premolar (0.93 mm) and at the furcation area in the molar (2.3 mm). When the natural tooth and the replica tooth were compared, the largest euclidean distance was found at the root tip in the premolar (1.5 mm) and at the furcation area in the molar (1.9 mm).

Conclusion

A CBCT scan maintains sufficient image quality for tooth autotransplantation planning. The replica tooth corresponded in size and shape to the natural tooth in terms of clinically expected need of precision.

背景：本研究评估了 CBCT 重建模型与天然牙相比的准确性，以及复制牙与天然牙相比的准确性：本研究评估了CBCT重建模型与天然牙相比的准确性，以及仿制牙与天然牙相比的准确性：方法：选取三颗牙齿，将其 CBCT 重建模型与天然牙齿进行对比，并对其准确性进行评估：方法：选取三颗牙齿，并根据每颗牙齿制作 CBCT 重建模型。将 STL 数据传输到铣床，用 PEEK 材料铣出仿制牙。用立体摄影测量扫描仪从天然牙和仿制牙上制作数字化表面模型。将天然牙齿光学扫描的表面模型与 CBCT 重建模型和仿制牙齿的表面模型进行比较。模型相互匹配，表面模型之间进行基于表面的刚性配准。结果：结果：CBCT 重建模型与天然牙齿进行了比较。最大的欧氏距离出现在前臼齿的根尖（0.93 毫米）和臼齿的沟区（2.3 毫米）。将天然牙和复制牙进行比较，发现前磨牙根尖（1.5 毫米）和臼齿沟区（1.9 毫米）的欧氏距离最大：结论：CBCT 扫描为牙齿自动移植规划提供了足够的图像质量。就临床预期的精度要求而言，复制牙齿的大小和形状与天然牙齿一致。

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引用次数: 0

Combined Phase 1/2a Initial Clinical Safety Trials and Proof-of-Concept Assessment of a Novel Antimicrobial Peptide KSL-W Anti-Plaque Chewing Gum 新型抗菌肽 KSL-W Anti-Plaque 嚼胶的 1/2a 期初步临床安全性联合试验和概念验证评估。

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research

Pub Date : 2024-10-28 DOI: 10.1002/cre2.943

J. Brett Ryan, Brian J. Kirkwood, Kai P. Leung

Objectives

The effective control of dental plaque is crucial for oral health, given that pathogenic bacteria in plaque are the primary cause of dental caries. Current antimicrobial agents, although effective, disrupt the oral microbiome and lead to oral dysbiosis, hindering efforts to curb dental caries. Novel antimicrobial peptides offer a promising solution due to their selective bactericidal activity against cariogenic bacteria. This study explores the initial safety and efficacy of KSL-W formulated into chewing gum through a Phase 1 and 2a clinical trial.

Methods

The combined trial, approved by the FDA, follows a double-blind, randomized, placebo-controlled design. Phase 1 assessed safety with single doses (2−100 mg), whereas Phase 2a explored both safety and proof of concept in reducing oral bacteria with multiple doses (4−75 mg). Besides adverse events (Phase 1), outcome measures included whole-mouth plaque and gingival index scores and bleeding on probing (Phase 2a).

Results

KSL-W demonstrated safety in both phases, with no severe adverse events. The proof-of-concept analysis revealed a decrease in plaque and gingival inflammation, particularly at doses ≥ 20 mg. The 30 mg dose appeared to yield optimal effects without any adverse reactions in subjects.

Conclusions

Results from this study indicate that KSL-W is safe for use in humans and provides initial evidence of its potential efficacy in reducing plaque and gingival inflammation. Further research is essential to determine optimal usage and ultimate safety, and to assess its potential in diverse populations.

Trial Registration

The trial is registered with the FDA (Trial Registration Number: NCT01877421). The clinical trials were registered in the clinicaltrials.gov database under the title “Safety and Tolerability of Antiplaque Chewing Gum in a Gingivitis Population” and the identifier number is NCT01877421. The URL for accessing the study in clinicaltrials.gov is https://clinicaltrials.gov/study/NCT01877421?intr=Antiplaque%20chewing&rank=1.

目的：有效控制牙菌斑对口腔健康至关重要，因为牙菌斑中的致病菌是导致龋齿的主要原因。目前的抗菌剂虽然有效，但会破坏口腔微生物群，导致口腔菌群失调，阻碍遏制龋齿的努力。新型抗菌肽对致癌细菌具有选择性杀菌活性，因此是一种很有前景的解决方案。本研究通过 1 期和 2a 期临床试验，探讨了将 KSL-W 配制成口香糖的初步安全性和有效性：经美国食品及药物管理局批准，该联合试验采用双盲、随机、安慰剂对照设计。第 1 期评估了单剂量（2-100 毫克）的安全性，而第 2a 期则探讨了多剂量（4-75 毫克）的安全性和减少口腔细菌的概念验证。除了不良反应（1期），结果指标还包括全口牙菌斑和牙龈指数评分以及探诊出血（2a期）：结果：KSL-W 在两个阶段都表现出安全性，没有出现严重的不良反应。概念验证分析显示，牙菌斑和牙龈炎症有所减轻，尤其是剂量≥20毫克时。30毫克的剂量似乎产生了最佳效果，受试者没有出现任何不良反应：本研究结果表明，KSL-W 可安全用于人体，并初步证明了其在减少牙菌斑和牙龈炎症方面的潜在功效。进一步的研究对于确定最佳用法和最终安全性以及评估其在不同人群中的潜力至关重要：该试验已在美国食品和药物管理局注册（试验注册号：NCT01877421）。临床试验已在 clinicaltrials.gov 数据库中注册，标题为 "Antiplaque 嚼胶在牙龈炎人群中的安全性和耐受性"，标识号为 NCT01877421。在 clinicaltrials.gov 中访问该研究的网址是 https://clinicaltrials.gov/study/NCT01877421?intr=Antiplaque%20chewing&rank=1。

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引用次数: 0

Effects of Adding Tricalcium Silicate Nanoparticles to the Universal G2 Bond Adhesive as Self-Etch Mode on the Shear Bond Strength to the Orthodontic Bracket 在通用 G2 粘接剂中添加纳米硅酸三钙颗粒作为自蚀模式对正畸托槽剪切粘接强度的影响

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research

Pub Date : 2024-10-25 DOI: 10.1002/cre2.948

Yasir R. Al-Labban, Mehdi Alrubayee, Syed Jaffar Abbas Zaidi, Shakeel Kazmi

Objective

This study investigated the effects of adding tricalcium silicate nanoparticles (TCSNp) to the universal G2 bond adhesive (G2BU) in self-etch (SE) mode on shear bond strength (SBS) to orthodontic brackets, cytotoxicity, and degree of conversion (DC).

Material and Methods

A total of 176 human teeth were divided into four groups based on TCSNp concentration in G2BU adhesive: 0% (control), 1%, 3%, and 5%. The G2BU adhesive consists of a hydrophilic primer (P) and a hydrophobic bonding agent (2B). TCSNp were added to the 2B component by mixing 0.1, 0.3, and 0.5 g of TCSNp with 9.9, 9.7, and 9.5 g of 2B, respectively. SBS was assessed after 24 h of water storage and 5000 thermocycles using a universal testing machine. Cytotoxicity was evaluated using the MTT assay on rat embryo fibroblast cells, and DC was measured using fourier-transform infrared spectroscopy. Statistical analysis included one-way ANOVA and Tukey's post-hoc test, with significance set at p < 0.05.

Results

After 24 h, mean SBS values were 15.58 MPa (control), 13.66 MPa (1% TCSNp), 15.99 MPa (3% TCSNp), and 12.04 MPa (5% TCSNp). After 5000 thermocycles, SBS values decreased to 12.91 MPa (control), 12.42 MPa (1% TCSNp), 11.11 MPa (3% TCSNp), and 10.21 MPa (5% TCSNp). ANOVA showed significant differences between groups (p < 0.05), except between the control and 3% TCSNp groups. Cell viability increased with higher TCSNp concentrations, with significant differences at 72 h between control and 5% TCSNp groups (p = 0.014). Mean DC values were 51.66% (control), 49.33% (1% TCSNp), 49.66% (3% TCSNp), and 48% (5% TCSNp). ANOVA indicated no significant differences between groups.

Conclusions

Adding TCSNp to G2BU in SE mode maintains clinically acceptable SBS levels and enhances cytocompatibility. Higher TCSNp concentrations may reduce SBS and DC slightly. Further studies are needed to evaluate long-term effects.

研究目的本研究探讨了在通用 G2 粘接剂（G2BU）中添加纳米硅酸三钙颗粒（TCSNp），在自酸蚀（SE）模式下对正畸托槽剪切粘接强度（SBS）、细胞毒性和转换度（DC）的影响：根据 G2BU 粘合剂中 TCSNp 的浓度将 176 颗人类牙齿分为四组：0%（对照组）、1%、3% 和 5%。G2BU 粘合剂由亲水性底漆（P）和疏水性粘接剂（2B）组成。将 0.1、0.3 和 0.5 克 TCSNp 分别与 9.9、9.7 和 9.5 克 2B 混合后添加到 2B 组份中。经过 24 小时的水储存和使用万能试验机进行 5000 次热循环后，对 SBS 进行了评估。细胞毒性采用 MTT 法对大鼠胚胎成纤维细胞进行评估，DC 采用傅立叶变换红外光谱法进行测量。统计分析包括单因素方差分析和 Tukey 的事后检验，显著性以 p 为标准：24 小时后，平均 SBS 值分别为 15.58 兆帕（对照组）、13.66 兆帕（1% TCSNp）、15.99 兆帕（3% TCSNp）和 12.04 兆帕（5% TCSNp）。经过 5000 次热循环后，SBS 值分别降至 12.91 兆帕（对照组）、12.42 兆帕（1% TCSNp）、11.11 兆帕（3% TCSNp）和 10.21 兆帕（5% TCSNp）。方差分析显示各组之间存在明显差异（p 结论：TCSNp 和 TCSNp 在 GBS 中的比例为 1:1：在 SE 模式下向 G2BU 中添加 TCSNp 可保持临床可接受的 SBS 水平并增强细胞相容性。较高浓度的 TCSNp 可能会略微降低 SBS 和 DC。需要进一步研究以评估长期效果。

{"title":"Effects of Adding Tricalcium Silicate Nanoparticles to the Universal G2 Bond Adhesive as Self-Etch Mode on the Shear Bond Strength to the Orthodontic Bracket","authors":"Yasir R. Al-Labban, Mehdi Alrubayee, Syed Jaffar Abbas Zaidi, Shakeel Kazmi","doi":"10.1002/cre2.948","DOIUrl":"10.1002/cre2.948","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study investigated the effects of adding tricalcium silicate nanoparticles (TCSNp) to the universal G2 bond adhesive (G2BU) in self-etch (SE) mode on shear bond strength (SBS) to orthodontic brackets, cytotoxicity, and degree of conversion (DC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>A total of 176 human teeth were divided into four groups based on TCSNp concentration in G2BU adhesive: 0% (control), 1%, 3%, and 5%. The G2BU adhesive consists of a hydrophilic primer (P) and a hydrophobic bonding agent (2B). TCSNp were added to the 2B component by mixing 0.1, 0.3, and 0.5 g of TCSNp with 9.9, 9.7, and 9.5 g of 2B, respectively. SBS was assessed after 24 h of water storage and 5000 thermocycles using a universal testing machine. Cytotoxicity was evaluated using the MTT assay on rat embryo fibroblast cells, and DC was measured using fourier-transform infrared spectroscopy. Statistical analysis included one-way ANOVA and Tukey's post-hoc test, with significance set at <i>p</i> < 0.05.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After 24 h, mean SBS values were 15.58 MPa (control), 13.66 MPa (1% TCSNp), 15.99 MPa (3% TCSNp), and 12.04 MPa (5% TCSNp). After 5000 thermocycles, SBS values decreased to 12.91 MPa (control), 12.42 MPa (1% TCSNp), 11.11 MPa (3% TCSNp), and 10.21 MPa (5% TCSNp). ANOVA showed significant differences between groups (<i>p</i> < 0.05), except between the control and 3% TCSNp groups. Cell viability increased with higher TCSNp concentrations, with significant differences at 72 h between control and 5% TCSNp groups (<i>p</i> = 0.014). Mean DC values were 51.66% (control), 49.33% (1% TCSNp), 49.66% (3% TCSNp), and 48% (5% TCSNp). ANOVA indicated no significant differences between groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Adding TCSNp to G2BU in SE mode maintains clinically acceptable SBS levels and enhances cytocompatibility. Higher TCSNp concentrations may reduce SBS and DC slightly. Further studies are needed to evaluate long-term effects.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"10 6","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11502968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comparison Between Three Types of Scaffolds for Pulp Regeneration: A Histological Study on Dogs 三种牙髓再生支架的比较：狗的组织学研究

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research

Pub Date : 2024-10-23 DOI: 10.1002/cre2.70031

Aliaa Alshahhoud, Mhd. Salem Rikab, Nizar Issa, Ahmad Manadili, Yasser Alsayed Tolaibah

Objectives

This study aims to compare the application of three types of normal scaffolds—native chitosan, enzymatically modified chitosan, and blood clot (BC)—on pulp regeneration in the teeth of experimental dogs through histological examination, to determine the quantity and type of new tissues formed within the root canal.

Materials and Methods

The research sample consisted of 32 root canals from 20 premolars of two male local experimental dogs. The sample was randomly divided into a control group, in which no intervention was performed on the teeth, and three experimental groups based on the type of scaffold used: the BC group, the native chitosan combined with BC (NCS + BC) group, and the enzymatically modified chitosan combined with BC (EMCS + BC) group. Mechanical and chemical cleaning of the canals was performed, followed by the application of the studied scaffolds within the root canals. After 3 months, the teeth were extracted and prepared for histological study, where two variables were studied: the percentage of total vital tissue (soft and hard; VT%) and the percentage of soft vital tissue only (ST%). A one-way ANOVA and Bonferroni tests were used to determine significant differences between the groups at a 95% confidence level.

Results

The VT% values were significantly higher in the EMCS + BC group compared to both the NCS + BC and BC groups. The ST% values were also significantly higher in the EMCS + BC group compared to the BC group. However, no significant differences in ST% values were observed between the NCS + BC group and either the BC or EMCS + BC groups.

Conclusions

Within the limitations of this study, we conclude that the application of enzymatically modified chitosan scaffolds combined with BC yields superior results in pulp regeneration, which contributes to the formation of pulp-like tissue and cells resembling odontoblasts, as well as apex closure with tissue resembling bone tissue.

研究目的本研究旨在通过组织学检查比较三种普通支架--原生壳聚糖、酶改性壳聚糖和血凝块（BC）--在实验犬牙齿牙髓再生中的应用，以确定根管内形成的新组织的数量和类型：研究样本包括两只雄性本地实验犬 20 颗前臼齿的 32 个根管。样本随机分为对照组和三个实验组，对照组不对牙齿进行任何干预，实验组则根据所用支架的类型分为 BC 组、天然壳聚糖与 BC 结合（NCS + BC）组和酶改性壳聚糖与 BC 结合（EMCS + BC）组。先对根管进行机械和化学清洗，然后在根管内应用所研究的支架。3 个月后，拔出牙齿并准备进行组织学研究，其中研究了两个变量：总活力组织的百分比（软和硬；VT%）和仅软活力组织的百分比（ST%）。在 95% 的置信水平下，采用单因素方差分析和 Bonferroni 检验来确定组间的显著差异：结果：EMCS + BC 组的 VT% 值明显高于 NCS + BC 组和 BC 组。与 BC 组相比，EMCS + BC 组的 ST% 值也明显更高。然而，NCS + BC 组与 BC 组或 EMCS + BC 组之间的 ST% 值无明显差异：在本研究的局限性范围内，我们得出结论：应用酶改性壳聚糖支架结合 BC 在牙髓再生方面产生了卓越的效果，有助于形成牙髓样组织和类似牙本质细胞的细胞，以及具有类似骨组织的组织的牙尖闭合。

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引用次数: 0

Tumor Metastasis to the Oral Soft Tissues and Jaw Bones: A Retrospective Study and Review of the Literature 肿瘤转移至口腔软组织和颌骨：回顾性研究与文献综述

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research

Pub Date : 2024-10-17 DOI: 10.1002/cre2.70011

Atessa Pakfetrat, Zohreh Dalirsani, Nasrollah Saghravanian, Kazem Anvari, Sajede Asalian, Armaghan Salehi, Mahboobeh Taherizadeh

Objectives

Metastasis to the oral soft tissues and jaw is rare and accounts for 1%–3% of maxillofacial malignancies. These lesions usually occur in the context of an extensive malignant tumor with a poor prognosis.

Materials and Methods

Archived cases from the Oral and Maxillofacial Pathology Department of the Faculty of Dentistry and two hospital centers of Mashhad University of Medical Sciences were examined. Inclusion criteria were cases with available records of pathologically confirmed metastatic lesions of the oral cavity with or without diagnosed primary malignancy.

Results

Metastatic lesions in the oral cavity and jaw were found in 18 patients, including seven women and 11 men, with a mean age of 49.5 years. Metastatic lesions were more common in the jaw (66%) and particularly in the mandible (38%) than elsewhere. In the case of soft tissue metastases, the gingiva was more affected than other sites. The primary tumor was most commonly in the kidney in men and in the breast in women (36%–28%). In addition, the diagnosis of a metastatic lesion led to the detection of the primary tumor elsewhere in six out of 18 cases (33.3%).

Conclusions

Early diagnosis of the lesions is challenging, given the absence of specific signs or symptoms, which, in some cases, nonetheless resemble inflammatory, benign, reactive lesions. Therefore, dentists play a crucial role in diagnosing such lesions, as they lead to the discovery of hidden distant primary tumors. Biopsy should always be considered for suspicious lesions, even if the probability is very low.

目标转移到口腔软组织和颌骨的情况很少见，占颌面部恶性肿瘤的 1%-3%。这些病变通常发生在预后不良的广泛恶性肿瘤中。材料与方法研究对象为马什哈德医科大学牙科学院口腔颌面病理系和两个医院中心的存档病例。纳入标准为有病理证实的口腔转移性病变病例，无论是否确诊为原发性恶性肿瘤。结果在 18 名患者中发现了口腔和颌骨转移性病变，包括 7 名女性和 11 名男性，平均年龄为 49.5 岁。与其他部位相比，转移病灶更常见于颌骨（66%），尤其是下颌骨（38%）。在软组织转移病例中，牙龈的受影响程度高于其他部位。原发肿瘤最常见的部位是男性的肾脏和女性的乳房（36%-28%）。此外，在 18 个病例中，有 6 个病例（33.3%）在诊断出转移病灶后发现了其他部位的原发肿瘤。结论由于没有特异性体征或症状，病变的早期诊断具有挑战性，在某些病例中，病变类似于炎症、良性和反应性病变。因此，牙医在诊断这类病变方面起着至关重要的作用，因为他们可以发现隐藏的远处原发肿瘤。对于可疑病变，即使可能性很低，也应考虑进行活组织检查。

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引用次数: 0