Clinical and Experimental Dental Research最新文献_第2页

Effect of Crown to Titanium Base Ratio and Force Angle on the Biomechanical Behavior of Dental Implants With CAD/CAM Zirconia and Lithium Disilicate Crowns: A Finite Element Analysis. 冠与钛基比和力角对CAD/CAM氧化锆和二硅酸锂冠种植体生物力学行为的影响

IF 2.2 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research

Pub Date : 2026-02-01 DOI: 10.1002/cre2.70296

Sara Abtahi, Shamim Mirzaboland, Allahyar Geramy, Marzieh Alikhasi, Hakimeh Siadat

Objectives: This study investigates how titanium-base (Ti-base) abutment height, crown design, and force angulation affect biomechanics in an anterior single-implant restoration, using finite element analysis.

Material and methods: A three-dimensional anterior maxilla model was constructed with linear elastic properties. Two Ti-base heights (3.5, 5.5 mm) and two crown heights (8, 11 mm) were tested as monolithic zirconia or bilayer (zirconia core veneered with lithium disilicate). A 146 N load was applied at the cingulum at 45° or 65°. von Mises stress (VMS) was computed in the crown, abutment, and surrounding bone.

Results: A 3.5 mm Ti-base with an 8 mm monolithic zirconia crown (SSZ) produced the lowest crown and abutment VMS. The highest crown VMS occurred in the 11 mm bilayer crown on a 5.5 mm Ti-base (LLZEX) at 45°, while the highest abutment VMS occurred in the 3.5 mm Ti-base with an 8 mm bilayer crown (SSZEX) at 65°. An increase in crown height raises crown stresses, whereas the impact of abutment height depends on configuration and angle. In bone, 45° loading increased VMS compared with 65° across all models.

Conclusions: In anterior single-implant models, the lowest restoration stresses were achieved with a short crown on a 3.5-mm Ti-base and monolithic zirconia. Long crowns (11 mm) increased crown stresses, and abutment height should be tailored to material and anticipated loading direction rather than adjusted by a single rule. Oblique loading consistently raised bone stress compared with 65°, underscoring the need to optimize for axial force transmission.

目的：本研究通过有限元分析探讨钛基基（Ti-base）基台高度、冠设计和力角度对前牙单种植体修复生物力学的影响。材料与方法：建立具有线弹性的上颌骨三维模型。两种钛基高度（3.5、5.5 mm）和两种冠高度（8、11 mm）分别被测试为单片氧化锆或双层氧化锆（氧化锆核心贴有二硅酸锂）。在带带45°或65°处施加146 N的载荷。计算冠、基牙和周围骨的von Mises应力（VMS）。结果：3.5 mm钛基牙配8mm单片氧化锆冠（SSZ）形成最低冠基牙VMS。最高的冠VMS发生在5.5 mm钛基（LLZEX）的45°位置上的11 mm双层冠上，而最高的基台VMS发生在3.5 mm钛基（SSZEX）的65°位置上的8 mm双层冠上。牙冠高度增加会增加牙冠应力，而基台高度对牙冠应力的影响取决于基台的结构和角度。在骨中，与65°相比，45°载荷增加了所有模型的VMS。结论：在前路单种植体模型中，在3.5 mm钛基体和整体氧化锆上使用短冠可以获得最低的修复应力。长牙冠（11mm）会增加牙冠应力，牙台高度应根据材料和预期的加载方向进行调整，而不是根据单一规则进行调整。与65°斜向载荷相比，斜向载荷持续提高骨应力，强调了优化轴向力传递的必要性。

{"title":"Effect of Crown to Titanium Base Ratio and Force Angle on the Biomechanical Behavior of Dental Implants With CAD/CAM Zirconia and Lithium Disilicate Crowns: A Finite Element Analysis.","authors":"Sara Abtahi, Shamim Mirzaboland, Allahyar Geramy, Marzieh Alikhasi, Hakimeh Siadat","doi":"10.1002/cre2.70296","DOIUrl":"10.1002/cre2.70296","url":null,"abstract":"<p><strong>Objectives: </strong>This study investigates how titanium-base (Ti-base) abutment height, crown design, and force angulation affect biomechanics in an anterior single-implant restoration, using finite element analysis.</p><p><strong>Material and methods: </strong>A three-dimensional anterior maxilla model was constructed with linear elastic properties. Two Ti-base heights (3.5, 5.5 mm) and two crown heights (8, 11 mm) were tested as monolithic zirconia or bilayer (zirconia core veneered with lithium disilicate). A 146 N load was applied at the cingulum at 45° or 65°. von Mises stress (VMS) was computed in the crown, abutment, and surrounding bone.</p><p><strong>Results: </strong>A 3.5 mm Ti-base with an 8 mm monolithic zirconia crown (SSZ) produced the lowest crown and abutment VMS. The highest crown VMS occurred in the 11 mm bilayer crown on a 5.5 mm Ti-base (LLZEX) at 45°, while the highest abutment VMS occurred in the 3.5 mm Ti-base with an 8 mm bilayer crown (SSZEX) at 65°. An increase in crown height raises crown stresses, whereas the impact of abutment height depends on configuration and angle. In bone, 45° loading increased VMS compared with 65° across all models.</p><p><strong>Conclusions: </strong>In anterior single-implant models, the lowest restoration stresses were achieved with a short crown on a 3.5-mm Ti-base and monolithic zirconia. Long crowns (11 mm) increased crown stresses, and abutment height should be tailored to material and anticipated loading direction rather than adjusted by a single rule. Oblique loading consistently raised bone stress compared with 65°, underscoring the need to optimize for axial force transmission.</p>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 1","pages":"e70296"},"PeriodicalIF":2.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12887446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Mediating Role of Biological Age Advance in the Association Between Periodontitis and Mortality: Biological Aging Links Periodontitis to Mortality. 生物年龄在牙周炎和死亡率之间的中介作用：生物衰老将牙周炎与死亡率联系起来。

IF 2.2 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research

Pub Date : 2026-02-01 DOI: 10.1002/cre2.70305

Dawei Zhang, Shijie Zhu, George Pelekos, Lijian Jin, Patrick Rijkschroeff

Objectives: This study aims to test a conceptual mediation model wherein periodontitis is associated with mortality through direct pathways and indirectly via accelerated biological aging.

Material and methods: We analyzed six cycles of National Health and Nutrition Examination Survey data with mortality follow-up of 250 months. Weighted descriptive statistics were used to compare group characteristics, Kaplan-Meier analysis to evaluate periodontitis-mortality associations and generalized linear models to examine the links between periodontitis and biological aging. Cox proportional hazards models integrated with restricted cubic splines were utilized to explore the association between biological age and mortality, and mediation analyses quantified the mediation of biological aging. Additionally, age, gender, and smoking status subgroup analyses were conducted.

Results: Moderate/severe periodontitis was associated with a significantly elevated all‑cause mortality risk (18.31% vs. 10.88% in no/mild periodontitis) and greater biological age advancement (PhenoAge: 1.22 years; KDM: 0.68 years). Biological age acceleration exhibited a non-linear association with mortality, with hazard ratios rising sharply beyond a threshold (PhenoAge: 16.4 years; KDM: 31.8 years). Mediation analysis showed that biological age partially mediated the periodontitis-mortality association, with indirect effect hazard ratios of 1.085 (95% CI: 1.067-1.106) for PhenoAge advance and 1.027 (95% CI: 1.016-1.040) for KDM advance in all‑cause mortality, though the proportion mediated was modest and varied across subgroups.

Conclusions: Our findings support the hypothesis that biological aging (assessed by PhenoAge and KDM advances) plays a significant, though partial, mediating role in the link between periodontitis and elevated mortality.

目的：本研究旨在验证一个概念性中介模型，其中牙周炎通过直接途径和间接通过加速生物衰老与死亡率相关。材料与方法：对6个周期的全国健康与营养调查数据进行分析，随访250个月。加权描述性统计用于比较各组特征，Kaplan-Meier分析用于评估牙周炎与死亡率的关联，广义线性模型用于检查牙周炎与生物衰老之间的联系。结合限制三次样条的Cox比例风险模型探讨了生物年龄与死亡率之间的关系，并通过中介分析量化了生物衰老的中介作用。此外，还进行了年龄、性别和吸烟状况亚组分析。结果：中度/重度牙周炎与显著升高的全因死亡风险（18.31% vs. 10.88%，无/轻度牙周炎）和较大的生物年龄进展（表型年龄：1.22 年；KDM: 0.68 年）相关。生物年龄加速与死亡率呈非线性关系，风险比急剧上升超过阈值（表型年龄：16.4岁；KDM: 31.8岁）。中介分析显示，生物年龄部分介导了牙周炎与死亡率的关联，在全因死亡率中，表型年龄进展的间接效应风险比为1.085 (95% CI: 1.067-1.106)， KDM进展的间接效应风险比为1.027 (95% CI: 1.016-1.040)，尽管介导的比例适中，且在不同亚组之间存在差异。结论：我们的研究结果支持这样的假设，即生物衰老（通过PhenoAge和KDM进展来评估）在牙周炎和死亡率升高之间的联系中起着重要的（尽管是部分的）中介作用。

{"title":"The Mediating Role of Biological Age Advance in the Association Between Periodontitis and Mortality: Biological Aging Links Periodontitis to Mortality.","authors":"Dawei Zhang, Shijie Zhu, George Pelekos, Lijian Jin, Patrick Rijkschroeff","doi":"10.1002/cre2.70305","DOIUrl":"10.1002/cre2.70305","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to test a conceptual mediation model wherein periodontitis is associated with mortality through direct pathways and indirectly via accelerated biological aging.</p><p><strong>Material and methods: </strong>We analyzed six cycles of National Health and Nutrition Examination Survey data with mortality follow-up of 250 months. Weighted descriptive statistics were used to compare group characteristics, Kaplan-Meier analysis to evaluate periodontitis-mortality associations and generalized linear models to examine the links between periodontitis and biological aging. Cox proportional hazards models integrated with restricted cubic splines were utilized to explore the association between biological age and mortality, and mediation analyses quantified the mediation of biological aging. Additionally, age, gender, and smoking status subgroup analyses were conducted.</p><p><strong>Results: </strong>Moderate/severe periodontitis was associated with a significantly elevated all‑cause mortality risk (18.31% vs. 10.88% in no/mild periodontitis) and greater biological age advancement (PhenoAge: 1.22 years; KDM: 0.68 years). Biological age acceleration exhibited a non-linear association with mortality, with hazard ratios rising sharply beyond a threshold (PhenoAge: 16.4 years; KDM: 31.8 years). Mediation analysis showed that biological age partially mediated the periodontitis-mortality association, with indirect effect hazard ratios of 1.085 (95% CI: 1.067-1.106) for PhenoAge advance and 1.027 (95% CI: 1.016-1.040) for KDM advance in all‑cause mortality, though the proportion mediated was modest and varied across subgroups.</p><p><strong>Conclusions: </strong>Our findings support the hypothesis that biological aging (assessed by PhenoAge and KDM advances) plays a significant, though partial, mediating role in the link between periodontitis and elevated mortality.</p>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 1","pages":"e70305"},"PeriodicalIF":2.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12887437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic Antifungal Effects of Honokiol and Fluconazole Against Oral Candida: Implications for Managing Drug-Resistant Infections 厚朴酚和氟康唑对口腔念珠菌的协同抗真菌作用：对耐药感染的管理意义。

IF 2.2 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research

Pub Date : 2026-01-29 DOI: 10.1002/cre2.70251

Maribasappa Karched, Mohammad Irshad, Jawad M. Behbehani

Objectives

Antifungal drug resistance poses a major challenge in treating oral Candida infections. This study aimed to evaluate the antifungal activity of Honokiol, alone and combined with Fluconazole, against oral Candida isolates, and to investigate its mechanism of action via ergosterol biosynthesis inhibition and cell wall disruption.

Material and Methods

Susceptibility testing was performed using CLSI (M27-A3) methodology on 16 oral Candida isolates, 8 endodontic isolates, and the reference strain ATCC 24433. Minimum inhibitory concentrations (MICs) of Honokiol and Fluconazole were determined alone and in combination. Ergosterol inhibitory assays and scanning electron microscopy (SEM) were used to assess cell wall integrity and morphological changes.

Results

Honokiol exhibited MICs of 16–64 µg/mL (oral isolates), 16 µg/mL (endodontic isolates), and 32 µg/mL (ATCC 24433). In combination with Fluconazole, Honokiol's MICs decreased 4-fold (4–16 µg/mL), while Fluconazole's MICs dropped 2- to 4-fold (1–32 µg/mL). Synergy was confirmed by a 95.61% reduction in fungal growth (OD600) compared to controls. SEM revealed severe cell wall distortion, rupture, and cytoplasmic leakage. Honokiol significantly inhibited ergosterol biosynthesis, disrupting cellular integrity.

Conclusion

Honokiol demonstrates potent antifungal activity against oral Candida isolates by targeting ergosterol biosynthesis and compromising cell wall integrity. Its synergistic enhancement of Fluconazole's effect suggests clinical potential as an adjunct therapy, potentially reducing resistance and lowering required drug doses in oral and endodontic candidiasis.

目的：抗真菌药物耐药性是口腔念珠菌感染治疗的主要挑战。本研究旨在评价本品单独及联合氟康唑对口腔念珠菌的抗真菌活性，并通过麦角甾醇生物合成抑制和细胞壁破坏等途径探讨其作用机制。材料与方法：采用CLSI （M27-A3）方法对16株口腔念珠菌、8株牙髓分离株和参考菌株ATCC 24433进行药敏试验。分别测定了本木酚和氟康唑单独和联合使用时的最低抑菌浓度（mic）。麦角甾醇抑制试验和扫描电镜（SEM）评估细胞壁完整性和形态变化。结果：本木酚的mic值分别为16 ~ 64µg/mL（口腔分离株）、16µg/mL（牙髓分离株）和32µg/mL （ATCC 24433）。与氟康唑联合使用时，本木酚的mic降低了4倍（4-16µg/mL），而氟康唑的mic降低了2- 4倍（1-32µg/mL）。与对照相比，真菌生长（OD600）减少了95.61%，证实了协同作用。扫描电镜显示严重的细胞壁扭曲、破裂和细胞质渗漏。厚朴酚显著抑制麦角甾醇的生物合成，破坏细胞完整性。结论：本木酚通过靶向麦角甾醇的生物合成和破坏细胞壁完整性，对口腔念珠菌具有有效的抗真菌活性。它的协同增强氟康唑的作用表明，作为一种辅助治疗的临床潜力，可能会减少口腔和牙髓念珠菌病的耐药性和降低所需的药物剂量。

{"title":"Synergistic Antifungal Effects of Honokiol and Fluconazole Against Oral Candida: Implications for Managing Drug-Resistant Infections","authors":"Maribasappa Karched, Mohammad Irshad, Jawad M. Behbehani","doi":"10.1002/cre2.70251","DOIUrl":"10.1002/cre2.70251","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Antifungal drug resistance poses a major challenge in treating oral <i>Candida</i> infections. This study aimed to evaluate the antifungal activity of Honokiol, alone and combined with Fluconazole, against oral <i>Candida</i> isolates, and to investigate its mechanism of action via ergosterol biosynthesis inhibition and cell wall disruption.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Susceptibility testing was performed using CLSI (M27-A3) methodology on 16 oral <i>Candida</i> isolates, 8 endodontic isolates, and the reference strain ATCC 24433. Minimum inhibitory concentrations (MICs) of Honokiol and Fluconazole were determined alone and in combination. Ergosterol inhibitory assays and scanning electron microscopy (SEM) were used to assess cell wall integrity and morphological changes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Honokiol exhibited MICs of 16–64 µg/mL (oral isolates), 16 µg/mL (endodontic isolates), and 32 µg/mL (ATCC 24433). In combination with Fluconazole, Honokiol's MICs decreased 4-fold (4–16 µg/mL), while Fluconazole's MICs dropped 2- to 4-fold (1–32 µg/mL). Synergy was confirmed by a 95.61% reduction in fungal growth (OD600) compared to controls. SEM revealed severe cell wall distortion, rupture, and cytoplasmic leakage. Honokiol significantly inhibited ergosterol biosynthesis, disrupting cellular integrity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Honokiol demonstrates potent antifungal activity against oral <i>Candida</i> isolates by targeting ergosterol biosynthesis and compromising cell wall integrity. Its synergistic enhancement of Fluconazole's effect suggests clinical potential as an adjunct therapy, potentially reducing resistance and lowering required drug doses in oral and endodontic candidiasis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12853974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146084363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cement Remnants Thickness After Polishing With Tungsten, Diamond, and Arkansas Bur Using Composite Customized Lingual Brackets 使用复合定制舌托，用钨、钻石和阿肯色Bur抛光后的水泥残余厚度。

IF 2.2 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research

Pub Date : 2026-01-29 DOI: 10.1002/cre2.70302

Javier Flores-Fraile, Alba Belanche Monterde, Francesca Gorassini, Álvaro Zubizarreta-Macho, Artak Heboyan, Cosimo Galletti

Introduction

There is no current evidence in the literature that clearly guides clinicians in selecting the most effective polishing protocol in lingual orthodontics. This study aimed to compare the reduction of adhesive remnants after polishing customized lingual composite brackets using tungsten carbide, fine diamond, and Arkansas burs.

Methods

A total of 504 extracted teeth were included and randomly assigned to three groups according to bur type (n = 168). Brackets were bonded and debonded following a standardized protocol, and digital scans were obtained before and after polishing. Each bur was tested at both low speed (contra-angle) and high speed (turbine).

Results

Tungsten carbide burs produced the greatest reduction in cement thickness under both rotary conditions. At low speed, the mean Pre–Post thickness differences were 0.64 mm (TUN), 0.31 mm (ARK), and 0.37 mm (DIA). At high speed, differences were 0.45 mm (TUN), 0.39 mm (ARK), and 0.41 mm (DIA). Statistically significant differences were found between the tungsten carbide group and both the Arkansas and diamond groups (p < 0.005), with no differences between the latter two.

Conclusion

Tungsten carbide burs removed significantly more adhesive than Arkansas and diamond burs, regardless of rotary speed. These findings support clinical decision-making by helping optimize polishing protocols in lingual orthodontics.

目前尚无文献证据明确指导临床医生在舌正畸中选择最有效的抛光方案。本研究旨在比较使用碳化钨、细金刚石和阿肯色毛刺抛光定制舌复合托槽后粘合剂残留的减少情况。方法：选取拔牙504颗，按牙型随机分为3组（n = 168）。支架按照标准协议粘合和剥离，并在抛光前后进行数字扫描。每个bur都在低速（对角）和高速（涡轮）下进行了测试。结果：碳化钨毛刺在两种旋转条件下均能最大程度地减少水泥厚度。低速时，平均Pre-Post厚度差为0.64 mm （TUN）、0.31 mm （ARK）和0.37 mm （DIA）。高速时，差异为0.45 mm （TUN）、0.39 mm （ARK）和0.41 mm （DIA）。结论：无论转速如何，碳化钨组与阿肯色组和金刚石组相比，碳化钨毛刺去除的黏合剂明显多于阿肯色组和金刚石组。这些发现通过帮助优化舌正畸抛光方案来支持临床决策。

{"title":"Cement Remnants Thickness After Polishing With Tungsten, Diamond, and Arkansas Bur Using Composite Customized Lingual Brackets","authors":"Javier Flores-Fraile, Alba Belanche Monterde, Francesca Gorassini, Álvaro Zubizarreta-Macho, Artak Heboyan, Cosimo Galletti","doi":"10.1002/cre2.70302","DOIUrl":"10.1002/cre2.70302","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>There is no current evidence in the literature that clearly guides clinicians in selecting the most effective polishing protocol in lingual orthodontics. This study aimed to compare the reduction of adhesive remnants after polishing customized lingual composite brackets using tungsten carbide, fine diamond, and Arkansas burs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 504 extracted teeth were included and randomly assigned to three groups according to bur type (<i>n</i> = 168). Brackets were bonded and debonded following a standardized protocol, and digital scans were obtained before and after polishing. Each bur was tested at both low speed (contra-angle) and high speed (turbine).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Tungsten carbide burs produced the greatest reduction in cement thickness under both rotary conditions. At low speed, the mean Pre–Post thickness differences were 0.64 mm (TUN), 0.31 mm (ARK), and 0.37 mm (DIA). At high speed, differences were 0.45 mm (TUN), 0.39 mm (ARK), and 0.41 mm (DIA). Statistically significant differences were found between the tungsten carbide group and both the Arkansas and diamond groups (<i>p</i> < 0.005), with no differences between the latter two.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Tungsten carbide burs removed significantly more adhesive than Arkansas and diamond burs, regardless of rotary speed. These findings support clinical decision-making by helping optimize polishing protocols in lingual orthodontics.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12853969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146084335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Association Between Serum Immunoglobulin G Titers Against Porphyromonas gingivalis and Chronic Kidney Disease in Patients With Rheumatoid Arthritis and Periodontitis: A Retrospective Cohort Study 类风湿关节炎和牙周炎患者血清抗牙龈卟啉单胞菌免疫球蛋白G滴度与慢性肾病的关系：一项回顾性队列研究

IF 2.2 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research

Pub Date : 2026-01-29 DOI: 10.1002/cre2.70271

Tetsuo Kobayashi, Satoshi Ito, Noriko Sugita, Akira Murasawa, Hajime Ishikawa, Koichi Tabeta

Objectives

Chronic kidney disease (CKD) is relatively common in patients with rheumatoid arthritis (RA). Periodontitis and periodontopathic Porphyromonas gingivalis are risk factors for CKD. However, the association of serum immunity to P. gingivalis and its peptidylarginine deiminase (PPAD), as well as periodontitis severity, with CKD in relation to RA has not been elucidated. The present study evaluated whether or not serum immunoglobulin G (IgG) titers against P. gingivalis and PPAD and periodontitis severity are associated with CKD in patients with RA and periodontitis.

Methods

Demographic, comorbidity, rheumatologic, and periodontal data were collected from 127 patients with RA and periodontitis in a retrospective cohort study. CKD was defined as an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m² and/or proteinuria of ≥ 3 months’ duration. Serum IgG titers against P. gingivalis and PPAD were determined using an electrochemiluminescence immunoassay.

Results

Twenty patients showed an eGFR < 60 mL/min/1.73 m², while no patients had proteinuria. The 20 CKD patients were significantly older (p = 0.002), had higher percentages of former smokers (p = 0.01), had more sites with probing depth and clinical attachment level ≥ 4 mm (p = 0.03 and p = 0.02), and had higher levels of serum creatinine and eGFR (p < 0.001 for both) and anti-P. gingivalis IgG titers (p = 0.04) than the 107 non-CKD patients. A significant association was observed between anti-P. gingivalis IgG titers and eGFR (p < 0.001 for both) by bivariate and multivariate analyses and between anti-P. gingivalis IgG titers and CKD (p < 0.001) using a multiple logistic regression analysis after adjusting for age, gender, smoking status, comorbidity, RA condition, and RA-related drugs.

Conclusions

These results suggest that serum IgG titers against P. gingivalis, but not against PPAD, are associated with CKD in patients with RA and periodontitis.

目的：慢性肾脏疾病（CKD）在类风湿关节炎（RA）患者中相对常见。牙周炎和牙周病性牙龈卟啉单胞菌是慢性肾病的危险因素。然而，血清对牙龈假单胞菌及其肽精氨酸脱亚胺酶（PPAD）的免疫，以及牙周炎的严重程度，与RA相关的CKD之间的关系尚未阐明。本研究评估了RA和牙周炎患者的血清免疫球蛋白G （IgG）滴度和牙周炎严重程度是否与CKD相关。方法：回顾性队列研究收集了127例RA合并牙周炎患者的人口统计学、合并症、风湿病学和牙周数据。CKD被定义为肾小球滤过率（eGFR） 2和/或蛋白尿持续时间≥3个月。采用电化学发光免疫分析法测定血清抗牙龈卟啉单胞菌和PPAD的IgG滴度。结果：20例患者出现eGFR 2，无蛋白尿。20例CKD患者明显年龄较大（p = 0.002），既往吸烟者比例较高（p = 0.01），有更多探诊深度和临床附着水平≥4 mm的部位（p = 0.03和p = 0.02），血清肌酐和eGFR水平较高(p)。结论：这些结果表明，RA和牙周炎患者的血清抗牙龈假单抗IgG滴度与CKD相关，而非抗PPAD滴度。

{"title":"The Association Between Serum Immunoglobulin G Titers Against Porphyromonas gingivalis and Chronic Kidney Disease in Patients With Rheumatoid Arthritis and Periodontitis: A Retrospective Cohort Study","authors":"Tetsuo Kobayashi, Satoshi Ito, Noriko Sugita, Akira Murasawa, Hajime Ishikawa, Koichi Tabeta","doi":"10.1002/cre2.70271","DOIUrl":"10.1002/cre2.70271","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Chronic kidney disease (CKD) is relatively common in patients with rheumatoid arthritis (RA). Periodontitis and periodontopathic <i>Porphyromonas gingivalis</i> are risk factors for CKD. However, the association of serum immunity to <i>P. gingivalis</i> and its peptidylarginine deiminase (PPAD), as well as periodontitis severity, with CKD in relation to RA has not been elucidated. The present study evaluated whether or not serum immunoglobulin G (IgG) titers against <i>P. gingivalis</i> and PPAD and periodontitis severity are associated with CKD in patients with RA and periodontitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Demographic, comorbidity, rheumatologic, and periodontal data were collected from 127 patients with RA and periodontitis in a retrospective cohort study. CKD was defined as an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m<sup>2</sup> and/or proteinuria of ≥ 3 months’ duration. Serum IgG titers against <i>P. gingivalis</i> and PPAD were determined using an electrochemiluminescence immunoassay.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty patients showed an eGFR < 60 mL/min/1.73 m<sup>2</sup>, while no patients had proteinuria. The 20 CKD patients were significantly older (<i>p</i> = 0.002), had higher percentages of former smokers (<i>p</i> = 0.01), had more sites with probing depth and clinical attachment level ≥ 4 mm (<i>p</i> = 0.03 and <i>p</i> = 0.02), and had higher levels of serum creatinine and eGFR (<i>p</i> < 0.001 for both) and anti-<i>P. gingivalis</i> IgG titers (<i>p</i> = 0.04) than the 107 non-CKD patients. A significant association was observed between anti-<i>P. gingivalis</i> IgG titers and eGFR (<i>p</i> < 0.001 for both) by bivariate and multivariate analyses and between anti-<i>P. gingivalis</i> IgG titers and CKD (<i>p</i> < 0.001) using a multiple logistic regression analysis after adjusting for age, gender, smoking status, comorbidity, RA condition, and RA-related drugs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These results suggest that serum IgG titers against <i>P. gingivalis</i>, but not against PPAD, are associated with CKD in patients with RA and periodontitis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12853967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146084325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomechanical Evaluation of Framework Materials in All-on-Four Versus All-on-Six Prostheses: A Finite Element Study 全上- 4与全上- 6假体框架材料的生物力学评价：有限元研究。

IF 2.2 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research

Pub Date : 2026-01-26 DOI: 10.1002/cre2.70277

Lala Cabbarova, Ali Rıza Tunçdemir, Reza Mohammadi

Purpose

The objective of this study was to biomechanically compare the All-on-Four and All-on-Six implant configurations combined with various framework materials by assessing stress distribution in peri-implant bone, implants, and prosthetic structures using finite element analysis (FEA).

Materials and Methods

This study investigated the biomechanical behavior of six different framework materials titanium, zirconia, PEEK, PEKK, Trilor and Trinia in full-arch, implant-supported fixed prostheses using the All-on-Four and All-on-Six concepts in a total edentulous mandible. A three dimensional finite element model of the mandible, incorporating cortical and trabecular bone as well as mucosal tissue, was developed based on CBCT data. In the All-on-Four configuration, two anterior implants were placed axially and two posterior implants were tilted distally at 30°. The All-on-Six model featured axially placed anterior implants, with posterior implants angled at 15° in the premolar and 30° in the molar regions. Multi-unit abutments were used for all implants. Frameworks were digitally designed in a Toronto prosthesis configuration using each material, and a monolithic zirconia superstructure was applied as the veneering material. All models were subjected to a simulated vertical masticatory load of 150 N. Maximum principal stress values were assessed in the peri-implant bone, while von Mises stress distributions were analyzed in the framework, implants, and fixation screws.

Results

The highest stress accumulation was observed in the All-on-Four configuration, particularly around the cantilever region and distal implants. Materials with low elastic modulus (PEEK and PEKK) caused higher stress transmission to peri-implant bone and connection components. In contrast, rigid materials (titanium and zirconia) provided a more balanced load distribution and resulted in lower stress concentrations. Glass fiber-reinforced composite frameworks (Trilor and Trinia) remained within clinically acceptable biomechanical limits.

Conclusion

The findings of this study indicated that both implant configuration and framework material properties play a critical role in the biomechanical performance and long-term success of the prosthesis.

目的：本研究的目的是通过有限元分析（FEA）评估种植体周围骨、种植体和假体结构的应力分布，比较不同框架材料的all -on- 4和all -on- 6种植体结构的生物力学差异。材料和方法：本研究采用all -on- 4和all -on- 6概念，研究了钛、氧化锆、PEEK、PEKK、Trilor和Trinia六种不同框架材料在全弓种植体支撑固定义肢中的生物力学行为。基于CBCT数据建立了包含皮质骨、骨小梁骨和粘膜组织的下颌骨三维有限元模型。在All-on-Four配置中，两个前牙种植体轴向放置，两个后牙种植体远端倾斜30°。All-on-Six模型的特点是轴向放置前牙种植体，后牙种植体在前磨牙区域呈15°角，在磨牙区域呈30°角。所有种植体均采用多单元基台。框架使用每种材料在多伦多假体配置中进行数字化设计，整体氧化锆上层结构用作贴面材料。所有模型均承受150 N的模拟垂直咀嚼载荷。评估种植体周围骨的最大主应力值，分析框架、种植体和固定螺钉的von Mises应力分布。结果：在All-on-Four配置中观察到最高的应力积累，特别是在悬臂区域和远端种植体周围。低弹性模量的材料（PEEK和PEKK）对种植体周围骨和连接部件的应力传递更高。相比之下，刚性材料（钛和氧化锆）提供了更平衡的负载分布，导致更低的应力集中。玻璃纤维增强复合框架（Trilor和Trinia）仍在临床可接受的生物力学范围内。结论：本研究结果表明，种植体结构和框架材料性能对假体的生物力学性能和长期成功起着至关重要的作用。

{"title":"Biomechanical Evaluation of Framework Materials in All-on-Four Versus All-on-Six Prostheses: A Finite Element Study","authors":"Lala Cabbarova, Ali Rıza Tunçdemir, Reza Mohammadi","doi":"10.1002/cre2.70277","DOIUrl":"10.1002/cre2.70277","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>The objective of this study was to biomechanically compare the All-on-Four and All-on-Six implant configurations combined with various framework materials by assessing stress distribution in peri-implant bone, implants, and prosthetic structures using finite element analysis (FEA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This study investigated the biomechanical behavior of six different framework materials titanium, zirconia, PEEK, PEKK, Trilor and Trinia in full-arch, implant-supported fixed prostheses using the All-on-Four and All-on-Six concepts in a total edentulous mandible. A three dimensional finite element model of the mandible, incorporating cortical and trabecular bone as well as mucosal tissue, was developed based on CBCT data. In the All-on-Four configuration, two anterior implants were placed axially and two posterior implants were tilted distally at 30°. The All-on-Six model featured axially placed anterior implants, with posterior implants angled at 15° in the premolar and 30° in the molar regions. Multi-unit abutments were used for all implants. Frameworks were digitally designed in a Toronto prosthesis configuration using each material, and a monolithic zirconia superstructure was applied as the veneering material. All models were subjected to a simulated vertical masticatory load of 150 N. Maximum principal stress values were assessed in the peri-implant bone, while von Mises stress distributions were analyzed in the framework, implants, and fixation screws.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The highest stress accumulation was observed in the All-on-Four configuration, particularly around the cantilever region and distal implants. Materials with low elastic modulus (PEEK and PEKK) caused higher stress transmission to peri-implant bone and connection components. In contrast, rigid materials (titanium and zirconia) provided a more balanced load distribution and resulted in lower stress concentrations. Glass fiber-reinforced composite frameworks (Trilor and Trinia) remained within clinically acceptable biomechanical limits.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The findings of this study indicated that both implant configuration and framework material properties play a critical role in the biomechanical performance and long-term success of the prosthesis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12834504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Periodontal Health Knowledge and Oral Hygiene Practices in a National Cohort of Thai Adults 牙周健康知识与口腔卫生习惯在泰国成人国家队列中的关系。

IF 2.2 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research

Pub Date : 2026-01-26 DOI: 10.1002/cre2.70297

Mana Naratippakorn, Paswach Wiriyakijja, Dissara Akkarasrisawad, Nirinya Raoprajong, Pirada Itthipolchai, Vivat Thongchotchat, Pimchanok Sutthiboonyapan

<div> <section> <h3> Objectives</h3> <p>Periodontitis is a common oral disease that affects populations globally, however, awareness of periodontal disease prevention remains limited. Since periodontal health knowledge may influence oral hygiene behaviors, which are essential for disease prevention and long-term maintenance, this study aimed to assess periodontal health-related knowledge and its association with oral hygiene practices among an adult cohort in Thailand using the validated Adult Periodontal Health Knowledge and Belief Questionnaire.</p> </section> <section> <h3> Material and Methods</h3> <p>A cross-sectional survey of Thai adults (≥ 18 years) was conducted from December 2023 to January 2024. The questionnaire captured demographics, oral hygiene practices (brushing and interdental cleaning), and periodontal health knowledge (ALPHA-K). Descriptive statistics, non-parametric tests, exploratory factor analysis, and multiple linear regression were used.</p> </section> <section> <h3> Results</h3> <p>A total of 1770 participants completed the survey. The mean ALPHA-K score was 11.83 (2.88), which represents 59.2% of total score. While most recognized that plaque as the cause of gum disease, and smoking and diabetes as risk factors, misconceptions persisted (e.g., floss only removes food; tooth loss is inevitable with ageing; fluoride prevents gum disease). Higher periodontal health knowledge was associated with favorable flossing practices, brushing practices (longer brushing duration, extra-soft/soft bristles, manual toothbrush use) and higher education, higher income, and urban residence.</p> </section> <section> <h3> Conclusions</h3> <p>A significant knowledge deficit regarding periodontal health exists in this Thai cohort, particularly among rural residents, individuals with lower income, and those reporting inadequate brushing duration or preference for hard bristle brushes or electric toothbrushes in Thailand. Disseminating accurate information on periodontal health and disease is essential to enhance self-care practices and overall periodontal health outcomes.</p> </section> <section> <h3> Public Health Relevance</h3> <p>Thai adults, particularly those with lower education levels and living in rural areas, demonstrated considerable gaps in periodontal health knowledge. Addressing these gaps through tailored educational interventions is important for improving population-level periodontal health outcomes.</p> </section>

目的：牙周炎是一种影响全球人群的常见口腔疾病，然而，对牙周病预防的认识仍然有限。由于牙周健康知识可能影响口腔卫生行为，而口腔卫生行为对疾病预防和长期维持至关重要，因此本研究旨在使用经过验证的成人牙周健康知识和信念问卷，评估泰国成人队列中牙周健康相关知识及其与口腔卫生习惯的关系。材料和方法：从2023年12月至2024年1月对泰国成年人（≥18岁）进行横断面调查。调查问卷包括人口统计、口腔卫生习惯（刷牙和牙间清洁）和牙周健康知识（ALPHA-K）。采用描述性统计、非参数检验、探索性因子分析和多元线性回归。结果：共有1770名参与者完成了调查。平均ALPHA-K评分为11.83分（2.88分），占总分的59.2%。虽然大多数人都认识到牙菌斑是牙龈疾病的原因，吸烟和糖尿病是危险因素，但误解仍然存在（例如，牙线只能清除食物；随着年龄的增长，牙齿脱落是不可避免的；氟化物可以预防牙龈疾病）。较高的牙周健康知识与良好的牙线使用习惯、刷牙习惯（更长的刷牙时间、超软/软刷毛、使用手动牙刷）、高等教育、高收入和城市居住有关。结论：在这一泰国队列中存在严重的牙周健康知识缺失，特别是在泰国农村居民、低收入个体和那些报告刷牙时间不足或偏好硬毛牙刷或电动牙刷的人群中。传播关于牙周健康和疾病的准确信息对于加强自我保健实践和整体牙周健康结果至关重要。公共卫生相关性：泰国成年人，特别是那些受教育程度较低和生活在农村地区的成年人，在牙周健康知识方面存在相当大的差距。通过量身定制的教育干预措施解决这些差距对于改善人口牙周健康结果非常重要。

{"title":"Association Between Periodontal Health Knowledge and Oral Hygiene Practices in a National Cohort of Thai Adults","authors":"Mana Naratippakorn, Paswach Wiriyakijja, Dissara Akkarasrisawad, Nirinya Raoprajong, Pirada Itthipolchai, Vivat Thongchotchat, Pimchanok Sutthiboonyapan","doi":"10.1002/cre2.70297","DOIUrl":"10.1002/cre2.70297","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Periodontitis is a common oral disease that affects populations globally, however, awareness of periodontal disease prevention remains limited. Since periodontal health knowledge may influence oral hygiene behaviors, which are essential for disease prevention and long-term maintenance, this study aimed to assess periodontal health-related knowledge and its association with oral hygiene practices among an adult cohort in Thailand using the validated Adult Periodontal Health Knowledge and Belief Questionnaire.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>A cross-sectional survey of Thai adults (≥ 18 years) was conducted from December 2023 to January 2024. The questionnaire captured demographics, oral hygiene practices (brushing and interdental cleaning), and periodontal health knowledge (ALPHA-K). Descriptive statistics, non-parametric tests, exploratory factor analysis, and multiple linear regression were used.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 1770 participants completed the survey. The mean ALPHA-K score was 11.83 (2.88), which represents 59.2% of total score. While most recognized that plaque as the cause of gum disease, and smoking and diabetes as risk factors, misconceptions persisted (e.g., floss only removes food; tooth loss is inevitable with ageing; fluoride prevents gum disease). Higher periodontal health knowledge was associated with favorable flossing practices, brushing practices (longer brushing duration, extra-soft/soft bristles, manual toothbrush use) and higher education, higher income, and urban residence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>A significant knowledge deficit regarding periodontal health exists in this Thai cohort, particularly among rural residents, individuals with lower income, and those reporting inadequate brushing duration or preference for hard bristle brushes or electric toothbrushes in Thailand. Disseminating accurate information on periodontal health and disease is essential to enhance self-care practices and overall periodontal health outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Public Health Relevance</h3>\u0000 \u0000 <p>Thai adults, particularly those with lower education levels and living in rural areas, demonstrated considerable gaps in periodontal health knowledge. Addressing these gaps through tailored educational interventions is important for improving population-level periodontal health outcomes.</p>\u0000 </section>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12834507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Open Proximal Contacts on Peri-Implant Diseases: A Systematic Review and Meta-Analysis 开放近端接触对种植体周围疾病的影响：系统回顾和荟萃分析。

IF 2.2 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research

Pub Date : 2026-01-26 DOI: 10.1002/cre2.70278

Momen A. Atieh, Maanas Shah, Abeer Hakam, Khaleifa Bohamedi, Andrew Tawse-Smith, Nabeel H. M. Alsabeeha

Objectives

The aim of this systematic review and meta-analysis was to evaluate the impact of open proximal contacts on peri-implant tissue changes, specifically marginal bone levels, probing pocket depth, and the incidence of peri-implant diseases.

Methods

Electronic databases were searched to identify non-randomized observational studies comparing open and closed proximal contacts. Risk of bias was assessed using the Cochrane Collaboration's tool and data were analyzed with a statistical software.

Results

Out of 276 studies initially identified, five met the inclusion criteria, involving 4882 dental implants. Meta-analysis indicated that open proximal contacts were associated with greater, but not statistically significant, marginal bone changes (mean difference (MD) 0.07; 95% confidence interval (CI) −0.09 to 0.24; p = 0.38); probing pocket depths (MD 0.11; 95% CI −0.29 to 0.51; p = 0.59) and a higher incidence of peri-implantitis (relative risk (RR) 1.63; 95% CI 0.88–3.02; p = 0.12) compared to closed contacts. Open proximal contact was associated with a significant increase in incidence of peri-implant mucositis (RR 1.74; 95% CI 1.06–2.86; p = 0.03).

Conclusions

Open proximal contacts are associated with increased probing pocket depths and marginal bone changes and could be a risk indicator for peri-implant mucositis. Further research is needed to assess long-term effects and to develop preventive measures.

目的：本系统综述和荟萃分析的目的是评估开放近端接触对种植体周围组织变化的影响，特别是边缘骨水平、探查袋深度和种植体周围疾病的发生率。方法：检索电子数据库，以确定比较开放和封闭近端接触的非随机观察性研究。使用Cochrane协作工具评估偏倚风险，并使用统计软件分析数据。结果：在最初确定的276项研究中，有5项符合纳入标准，涉及4882种种植体。meta分析显示，开放近端接触与较大但无统计学意义的边缘骨改变相关(平均差值（MD） 0.07；95%置信区间(CI) -0.09 ~ 0.24；p = 0.38)；探查袋深度（MD = 0.11; 95% CI = -0.29 ~ 0.51; p = 0.59）和种植体周围炎的发生率较高(相对危险度（RR） 1.63；95% ci 0.88-3.02；P = 0.12)。开放近端接触与种植体周围粘膜炎发生率显著增加相关（RR 1.74; 95% CI 1.06-2.86; p = 0.03）。结论：开放近端接触与探查袋深度增加和边缘骨改变有关，可能是种植体周围粘膜炎的危险指标。需要进一步的研究来评估长期影响和制定预防措施。

{"title":"Impact of Open Proximal Contacts on Peri-Implant Diseases: A Systematic Review and Meta-Analysis","authors":"Momen A. Atieh, Maanas Shah, Abeer Hakam, Khaleifa Bohamedi, Andrew Tawse-Smith, Nabeel H. M. Alsabeeha","doi":"10.1002/cre2.70278","DOIUrl":"10.1002/cre2.70278","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The aim of this systematic review and meta-analysis was to evaluate the impact of open proximal contacts on peri-implant tissue changes, specifically marginal bone levels, probing pocket depth, and the incidence of peri-implant diseases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Electronic databases were searched to identify non-randomized observational studies comparing open and closed proximal contacts. Risk of bias was assessed using the Cochrane Collaboration's tool and data were analyzed with a statistical software.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Out of 276 studies initially identified, five met the inclusion criteria, involving 4882 dental implants. Meta-analysis indicated that open proximal contacts were associated with greater, but not statistically significant, marginal bone changes (mean difference (MD) 0.07; 95% confidence interval (CI) −0.09 to 0.24; <i>p</i> = 0.38); probing pocket depths (MD 0.11; 95% CI −0.29 to 0.51; <i>p</i> = 0.59) and a higher incidence of peri-implantitis (relative risk (RR) 1.63; 95% CI 0.88–3.02; <i>p</i> = 0.12) compared to closed contacts. Open proximal contact was associated with a significant increase in incidence of peri-implant mucositis (RR 1.74; 95% CI 1.06–2.86; <i>p</i> = 0.03).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Open proximal contacts are associated with increased probing pocket depths and marginal bone changes and could be a risk indicator for peri-implant mucositis. Further research is needed to assess long-term effects and to develop preventive measures.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12834509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An 18-Month Randomized Controlled Clinical Trial Evaluating the Clinical Success of IPS e.max Conventional Crowns and Endocrowns in Extensively Restored Molars 评价IPS e.max常规冠和内冠在磨牙广泛修复中的临床成功的18个月随机对照临床试验。

IF 2.2 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research

Pub Date : 2026-01-26 DOI: 10.1002/cre2.70298

Rand Essa Dalol, Jihad Nouman Abou Nassar, Mohammad Y. Hajeer

Objectives

This RCT study aimed to investigate the clinical performance of IPS e.max endocrowns as an alternative option compared to conventional crowns to restore damaged molar teeth after an 18-month follow-up.

Materials and Methods

A sample of 30 patients with 40 molars, who needed a single-tooth restoration, was enrolled to receive either a conventional crown (n = 20) or an endocrown (n = 20). After molar preparation, all crowns were manufactured with the IPS e.max press system, then cemented using dual-cure resin. All crowns were assessed using the modified United States Public Health Service criteria (USPHS) at baseline, 6, 12, and 18 months following placement. Patient satisfaction was evaluated using a questionnaire. Statistical analyses were performed using Mann-Whitney U and Friedman tests (95% confidence interval).

Results

All teeth in the conventional crown group and endocrown group showed 100% clinical success with no failure at 6, 12, and 18 months after placement in terms of marginal adaptation, contact points, and surface texture. No significant difference was found between endocrowns and conventional crowns in adhesive failure at 6 months (p = 0.075), 12 months (p = 0.317), and 18 months (p = 1.000). 100% of patients were very satisfied with the esthetics and comfort of the prosthesis. The function percentage was 93.3%.

Conclusions

Both restorative options are durable and maintain their integrity. Adhesive failure occurred in a notable number of cases in the endocrown group compared to the conventional crown group. Patient satisfaction was high with both restoration types.

目的：通过18个月的随访，研究IPS e.max内冠与传统牙冠修复受损磨牙的临床表现。材料与方法：选取30例需要单牙修复的40颗磨牙患者，分别接受常规冠（n = 20）和内冠（n = 20）。磨牙制备完成后，采用IPS e.max压制系统制作全冠，并用双固化树脂粘接。在放置后的基线、6个月、12个月和18个月，使用修改后的美国公共卫生服务标准（USPHS）对所有冠进行评估。采用问卷调查评估患者满意度。采用Mann-Whitney U和Friedman检验进行统计分析（95%置信区间）。结果：常规冠组和内冠组在放置后6、12、18个月的边缘适应、接触点和表面质地方面均取得100%的临床成功。在6个月（p = 0.075）、12个月（p = 0.317）和18个月（p = 1.000）时，内冠与常规冠的粘接失效无显著差异。100%的患者对假体的美观和舒适性非常满意。功能百分率为93.3%。结论：两种修复方法都是持久的，并保持其完整性。与常规冠组相比，内冠组粘接剂失效的发生率显著高于常规冠组。两种修复方式的患者满意度均较高。

{"title":"An 18-Month Randomized Controlled Clinical Trial Evaluating the Clinical Success of IPS e.max Conventional Crowns and Endocrowns in Extensively Restored Molars","authors":"Rand Essa Dalol, Jihad Nouman Abou Nassar, Mohammad Y. Hajeer","doi":"10.1002/cre2.70298","DOIUrl":"10.1002/cre2.70298","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This RCT study aimed to investigate the clinical performance of IPS e.max endocrowns as an alternative option compared to conventional crowns to restore damaged molar teeth after an 18-month follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A sample of 30 patients with 40 molars, who needed a single-tooth restoration, was enrolled to receive either a conventional crown (<i>n</i> = 20) or an endocrown (<i>n</i> = 20). After molar preparation, all crowns were manufactured with the IPS e.max press system, then cemented using dual-cure resin. All crowns were assessed using the modified United States Public Health Service criteria (USPHS) at baseline, 6, 12, and 18 months following placement. Patient satisfaction was evaluated using a questionnaire. Statistical analyses were performed using Mann-Whitney U and Friedman tests (95% confidence interval).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>All teeth in the conventional crown group and endocrown group showed 100% clinical success with no failure at 6, 12, and 18 months after placement in terms of marginal adaptation, contact points, and surface texture. No significant difference was found between endocrowns and conventional crowns in adhesive failure at 6 months (<i>p</i> = 0.075), 12 months (<i>p</i> = 0.317), and 18 months (<i>p</i> = 1.000). 100% of patients were very satisfied with the esthetics and comfort of the prosthesis. The function percentage was 93.3%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Both restorative options are durable and maintain their integrity. Adhesive failure occurred in a notable number of cases in the endocrown group compared to the conventional crown group. Patient satisfaction was high with both restoration types.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12834506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Orthodontic Appliance-Related Mucosal Ulcerations in Newborns and Infants With Craniofacial Disorders 新生儿和颅面疾病患儿正畸矫治器相关粘膜溃疡。

IF 2.2 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research

Pub Date : 2026-01-20 DOI: 10.1002/cre2.70291

Christina Weismann, Kathrin Heise, Katharina Peters, Marit Bockstedte, Matthias C. Schulz, Cornelia Wiechers, Mirja Quante, Christian F. Poets, Bernd Koos, Maite Aretxabaleta

Objectives

In craniofacial disorders (CD) like cleft lip and/or palate (CL/P), Robin sequence (RS) or Down syndrome (DS), an early orthodontic intervention with different palatal plate devices is often applied. However, there are no data on complications such as mucosal ulcerations (MU).To determine the frequency and location of MU and evaluate associations with potential risk factors such as CD type, sex, appliance type, cleft location, underlying syndrome, and anatomical cleft morphology.

Materials and Methods

In a retrospective analysis, we searched our electronic patient records of newborn patients with CD admitted 01/2020-12/2022 for documented MU. For comparisons, Pearson's Chi-square or Fisher's Exact test were used, statistical significance was set at p < 0.05.

Results

A total of 248 patients (132 female, age range: 0–580 days) receiving 510 palatal plates were treated (51% CL/P, 26% RS; 24% DS); 81/248 (33%) infants had MU, occurring with 112/510 appliances (22%). MU were most common in RS patients (61/69; 88%), followed by CL/P (21/111; 19%). No MU were found in DS. MU occurrence differed significantly by type of orthodontic palatal plate (p < 0.0001). There was no significant association between sex, cleft location, presence of an underlying syndrome or cleft morphology and the occurrence of MU.

Conclusions

MU are common during palatal plate therapy. Our findings suggest that MU are correlated with both, the device's function and the mucosal load it applies. Parental training in device use and oral inspection, along with regular clinical check-ups, is advised to identify MU early, increase appliance quality and patient comfort.

目的：在唇裂/腭裂（CL/P）、罗宾序列（RS）或唐氏综合征（DS）等颅面疾病（CD）中，经常采用不同的腭板装置进行早期正畸干预。然而，没有关于粘膜溃疡（MU）等并发症的数据。确定MU的频率和位置，并评估其与CD类型、性别、器具类型、唇裂位置、潜在综合征和唇裂解剖形态等潜在危险因素的关系。材料和方法：通过回顾性分析，我们检索了2020年1月1日- 2022年12月收治的新生儿CD患者的电子病历，查找有MU记录的病例。结果：共有248例患者（女性132例，年龄0 ~ 580天）接受了510块腭板治疗（51% CL/ p, 26% RS, 24% DS）；81/248例（33%）患儿发生MU，其中112/510例（22%）患儿发生MU。MU在RS患者中最常见（61/69;88%），其次是CL/P（21/111; 19%）。DS未发现MU。结论：在腭板治疗中，MU是常见的。我们的研究结果表明，MU与设备的功能和它所应用的粘膜负荷都相关。建议对父母进行器械使用和口腔检查方面的培训，以及定期的临床检查，以尽早发现MU，提高器械质量和患者舒适度。

{"title":"Orthodontic Appliance-Related Mucosal Ulcerations in Newborns and Infants With Craniofacial Disorders","authors":"Christina Weismann, Kathrin Heise, Katharina Peters, Marit Bockstedte, Matthias C. Schulz, Cornelia Wiechers, Mirja Quante, Christian F. Poets, Bernd Koos, Maite Aretxabaleta","doi":"10.1002/cre2.70291","DOIUrl":"10.1002/cre2.70291","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>In craniofacial disorders (CD) like cleft lip and/or palate (CL/P), Robin sequence (RS) or Down syndrome (DS), an early orthodontic intervention with different palatal plate devices is often applied. However, there are no data on complications such as mucosal ulcerations (MU).To determine the frequency and location of MU and evaluate associations with potential risk factors such as CD type, sex, appliance type, cleft location, underlying syndrome, and anatomical cleft morphology.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>In a retrospective analysis, we searched our electronic patient records of newborn patients with CD admitted 01/2020-12/2022 for documented MU. For comparisons, Pearson's Chi-square or Fisher's Exact test were used, statistical significance was set at <i>p</i> < 0.05.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 248 patients (132 female, age range: 0–580 days) receiving 510 palatal plates were treated (51% CL/P, 26% RS; 24% DS); 81/248 (33%) infants had MU, occurring with 112/510 appliances (22%). MU were most common in RS patients (61/69; 88%), followed by CL/P (21/111; 19%). No MU were found in DS. MU occurrence differed significantly by type of orthodontic palatal plate (<i>p</i> < 0.0001). There was no significant association between sex, cleft location, presence of an underlying syndrome or cleft morphology and the occurrence of MU.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>MU are common during palatal plate therapy. Our findings suggest that MU are correlated with both, the device's function and the mucosal load it applies. Parental training in device use and oral inspection, along with regular clinical check-ups, is advised to identify MU early, increase appliance quality and patient comfort.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"12 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12820415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146009140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0