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Drug utilization studies in Turkiye: A systematic review. 土耳其的药物使用研究:系统回顾。
IF 1 2区 物理与天体物理 Q1 PHYSICS, MULTIDISCIPLINARY Pub Date : 2024-02-01 eCollection Date: 2024-01-01 DOI: 10.14744/nci.2023.60134
Ahmet Akici, Dieudonné Havyarimana, Ertan Direnc, Volkan Aydin

Objective: Drug utilization studies (DUS) provide a framework for drug utilization at the national or targeted population level and important information on unmet medical needs, particularly in assessing the rationality of drug use. We aimed to systematically review DUS conducted in Turkiye.

Methods: We examined 162 DUS with an accessible full-text, published as "research articles" and conducted in Turkiye between 2000 and 2021 using medical records and prescription data. We included English or Turkish papers with English abstracts. We examined the scientific characteristics of the publications, source of the data, place/time of collection, research designs, and studied drug groups.

Results: We found that 79.6% of articles were in English, 45.1% were listed in SCI/SCIE, and 63.0% were on the WOS platform with 3.5 (interquartile range: 1-15) citations. The mean study period and publication time were 2.9±3.1 and 2.9±2.1 years, respectively. The highest number of studies (17.9%) were published in 2021 and (26.5%) were conducted nationwide. We identified that 93.8% of the studies had retrospective design, 67.8% were conducted in secondary/tertiary health-care institutions, and 54.9% used direct hospital data. We detected that 68.5% of the studies were conducted on the general population, 19.1% on adults, 12.4% on children, and 44.4% were antibiotic oriented.

Conclusion: Our study showed that a significant portion of the DUS, the trend of which has gained momentum in recent years, was antibiotic focused and conducted with a retrospective design from hospital-based data collected on the general patient population. This situation points to the necessity of expanding the existing DUS range by effectively using the new advantages provided by medical record databases and conducting more DUS that can provide critical clues for specific patients and drug groups.

目的:药物利用研究(DUS)为全国或目标人群的药物利用提供了一个框架,并提供了有关未满足医疗需求的重要信息,尤其是在评估药物使用的合理性方面。我们旨在对土耳其进行的 DUS 进行系统回顾:我们利用医疗记录和处方数据,对 2000 年至 2021 年期间在土耳其进行的 162 篇可查阅全文的 DUS 进行了研究。我们收录了附有英文摘要的英文或土耳其文论文。我们研究了出版物的科学特征、数据来源、收集地点/时间、研究设计和研究药物组别:结果:我们发现79.6%的文章为英文,45.1%的文章被SCI/SCIE收录,63.0%的文章在WOS平台上发表,引用次数为3.5次(四分位间范围:1-15次)。平均研究时间(2.9±3.1)年,平均发表时间(2.9±2.1)年。发表于 2021 年的研究数量最多(17.9%),在全国范围内开展的研究数量最多(26.5%)。我们发现,93.8%的研究采用回顾性设计,67.8%的研究在二级/三级医疗机构进行,54.9%的研究直接使用医院数据。我们发现,68.5%的研究针对普通人群,19.1%针对成人,12.4%针对儿童,44.4%以抗生素为导向:我们的研究表明,近年来DUS的发展趋势是以抗生素为重点,并根据医院收集的普通患者数据进行回顾性设计。这种情况表明,有必要有效利用病历数据库提供的新优势,扩大现有的 DUS 范围,开展更多的 DUS,为特定患者和药物组提供重要线索。
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引用次数: 0
Heteronuclear Magnetisms with Ultracold Spinor Bosonic Gases in Optical Lattices 光晶格中的超冷自旋玻色气异核磁性
IF 3.5 2区 物理与天体物理 Q1 PHYSICS, MULTIDISCIPLINARY Pub Date : 2024-02-01 DOI: 10.1088/0256-307x/41/2/026701
Yongqiang Li, Chengkun Xing, Ming Gong, Guangcan Guo, Jianmin Yuan
Motivated by recent realizations of spin-1 NaRb mixtures in the experiments [Phys. Rev. Lett. 114, 255301 (2015); Phys. Rev. Lett. 128, 223201 (2022)], we investigate heteronuclear magnetism in the Mott-insulating regime. Different from the identical mixtures where the boson statistics only admits even parity states from angular momentum composition, for heteronuclear atoms in principle all angular momentum states are allowed, which can give rise to new magnetic phases. While various magnetic phases can be developed over these degenerate spaces, the concrete symmetry breaking phases depend on not only the degree of degeneracy but also the competitions from many-body interactions. We unveil these rich phases using the bosonic dynamical mean-field theory approach. These phases are characterized by various orders, including spontaneous magnetization order, spin magnitude order, singlet pairing order, and nematic order, which may coexist specially in the regime with odd parity. Finally we address the possible parameter regimes for observing these spin-ordered Mott phases.
最近在实验中实现了自旋-1 NaRb 混合物[Phys. Rev. Lett. 114, 255301 (2015);Phys. Rev. Lett. 128, 223201 (2022)],受此激励,我们研究了莫特绝缘体系中的异核磁性。在相同的混合物中,玻色子统计只允许角动量组成的偶奇偶态,而对于异核原子,原则上允许所有角动量态,这就可能产生新的磁相。虽然在这些退化空间中可以发展出各种磁相,但具体的对称性破缺相不仅取决于退化程度,还取决于多体相互作用的竞争。我们利用玻色动力学均场理论方法揭示了这些丰富的相位。这些阶段具有不同的阶数特征,包括自发磁化阶数、自旋幅度阶数、单子配对阶数和向列阶数,这些阶数在奇奇偶性机制中可能会特别共存。最后,我们探讨了观察这些自旋有序莫特相的可能参数机制。
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引用次数: 0
High Temperature Superconductivity in La3Ni2O7 La3Ni2O7 中的高温超导性
IF 3.5 2区 物理与天体物理 Q1 PHYSICS, MULTIDISCIPLINARY Pub Date : 2024-01-05 DOI: 10.1088/0256-307x/41/1/017402
Kun Jiang, Ziqiang Wang, Fu-chun Zhang
Motivated by the recent discovery of high-temperature superconductivity in bilayer La3Ni2O7 under pressure, we study its electronic properties and superconductivity due to strong electron correlation. Using the inversion symmetry, we decouple the low-energy electronic structure into block-diagonal symmetric and antisymmetric sectors. We find that the antisymmetric sector can be reduced to a one-band system near half filling, while the symmetric bands occupied by about two electrons are heavily overdoped individually. Using the strong coupling mean field theory, we obtain strong superconducting pairing with B 1g symmetry in the antisymmetric sector. We propose that due to the spin-orbital exchange coupling between the two sectors, B 1g pairing is induced in the symmetric bands, which in-turn boosts the pairing gap in the antisymmetric band and enhances the high-temperature superconductivity with a congruent d-wave symmetry in pressurized La3Ni2O7.
受最近在双层 La3Ni2O7 中发现的压力下高温超导现象的启发,我们研究了它的电子特性和强电子相关性导致的超导现象。利用反转对称性,我们将低能电子结构解耦为块对角对称和非对称扇区。我们发现,反对称扇区可以简化为接近半填充的单带系统,而由大约两个电子占据的对称带则单独存在严重的过掺杂。利用强耦合均场理论,我们在非对称扇区获得了具有 B 1g 对称性的强超导配对。我们提出,由于两个扇区之间的自旋轨道交换耦合,对称带中诱发了 B 1g 配对,这反过来又提高了非对称带中的配对间隙,增强了加压 La3Ni2O7 中具有同位 d 波对称性的高温超导能力。
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引用次数: 0
Localization Dynamics at the Exceptional Point of Non-Hermitian Creutz Ladder 非ermitian Creutz Ladder 异常点的定位动力学
IF 3.5 2区 物理与天体物理 Q1 PHYSICS, MULTIDISCIPLINARY Pub Date : 2024-01-05 DOI: 10.1088/0256-307x/41/2/027201
S. M. Zhang, T. Y. He, L. Jin
We propose a quasi-one-dimensional non-Hermitian Creutz ladder with entirely flat spectrum by introducing alternating gain and loss components while maintaining inversion symmetry. Destructive interference generates flat spectrum at the exceptional point, where the Creutz ladder maintains coalesced and degenerate eigenvalues with compact localized states distributed in single plaquette. All excitations are completely confined within the localization area, unaffected by gain and loss. Single-site excitations exhibit nonunitary dynamics with intensities increasing due to level coalescence, while multiple-site excitations may display oscillating or constant intensities at the exceptional point. These results provide insights into the fascinating dynamics of non-Hermitian localization, where level coalescence and degeneracy coexist at the exceptional point.
我们通过引入交替增益和损耗成分,同时保持反转对称性,提出了一种具有完全平坦频谱的准一维非赫米梯形克雷兹梯形。破坏性干扰在例外点产生平坦频谱,克雷兹梯形图在该点保持凝聚和退化特征值,并在单块板上分布紧凑的局部态。所有激发都完全限制在局部区域内,不受增益和损耗的影响。单位点激发表现出非单元动态,其强度会因位点凝聚而增加,而多位点激发则可能在特殊点上表现出振荡或恒定的强度。这些结果让我们深入了解了非赫米提局部化的迷人动态,在这种动态中,电平凝聚和退行性在超常点并存。
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引用次数: 0
A search for radio pulsars in supernova remnants using FAST with one pulsar discovered 利用 FAST 搜寻超新星遗迹中的射电脉冲星,发现一颗脉冲星
IF 3.5 2区 物理与天体物理 Q1 PHYSICS, MULTIDISCIPLINARY Pub Date : 2024-01-04 DOI: 10.1088/0256-307x/41/2/029701
Zhen Zhang, Wenming Yan, J. Yuan, Na Wang, Juntao Bai, Zhigang Wen, Baoda Li, Jintao Xie, De Zhao, Yubin Wang, Nannan Zhai
We report on the results of a search for radio pulsars in five supernova remnants (SNRs) with FAST. The observations were made using the 19-beam receiver in the Snapshot mode. The integration time for each pointing is 10 min. We discovered a new pulsar PSR J1845$-$0306 which has a spin period of 983.6 ms and a dispersion measure of 444.6$pm$2.0 cm$^{-3}$ pc in observations of SNR G29.6+0.1. To judge the association between the pulsar and the SNR, further verification is needed. We also re-detected some known pulsars in the data from SNRs G29.6+0.1 and G29.7$-$0.3. No pulsars were detected in observations of other three SNRs.
我们报告了利用 FAST 在五个超新星遗迹(SNR)中搜索射电脉冲星的结果。观测是在快照模式下使用 19 波束接收器进行的。每个测点的积分时间为 10 分钟。我们在对 SNR G29.6+0.1 的观测中发现了一颗新的脉冲星 PSR J1845$-$0306,它的自旋周期为 983.6 ms,色散测量值为 444.6$pm$2.0 cm$^{-3}$ pc。要判断脉冲星和SNR之间的联系,还需要进一步的验证。我们还在 SNR G29.6+0.1 和 G29.7$-$0.3 的数据中重新探测到了一些已知的脉冲星。在对其他三个自发核变星的观测中没有发现脉冲星。
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引用次数: 0
Profiling Electronic and Phononic Band Structures of Semiconductors at Finite Temperatures: Methods and Applications 在有限温度下剖析半导体的电子和声带结构:方法与应用
IF 3.5 2区 物理与天体物理 Q1 PHYSICS, MULTIDISCIPLINARY Pub Date : 2024-01-02 DOI: 10.1088/0256-307x/41/2/026301
Xie Zhang, Jun Kang, Su-Huai Wei
Semiconductor devices are often operated at elevated temperatures that are well above zero Kelvin, which is the temperature in most first-principles density functional calculations. Computational approaches to computing and understanding the properties of semiconductors at finite temperatures are thus in critical demand. In this review, we discuss the recent progress in computationally assessing the electronic and phononic band structures of semiconductors at finite temperatures. As an emerging semiconductor with particularly strong temperature-induced renormalization of the electronic and phononic band structures, halide perovskites are used as a representative example to demonstrate how computational advances may help to understand the band structures at elevated temperatures. Finally, we briefly illustrate the remaining computational challenges and outlook promising research directions that may help to guide future research in this field.
半导体器件通常在远高于零开尔文的高温下运行,而零开尔文正是大多数第一原理密度泛函计算的温度。因此,在有限温度下计算和理解半导体特性的计算方法需求量很大。在这篇综述中,我们将讨论在计算评估有限温度下半导体的电子和声带结构方面的最新进展。作为一种新兴的半导体,卤化物过氧化物具有特别强的温度诱导的电子和声波能带结构重正化,我们以这种半导体为例,说明计算的进步如何有助于理解高温下的能带结构。最后,我们简要说明了剩余的计算挑战,并展望了可能有助于指导该领域未来研究的前景光明的研究方向。
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引用次数: 0
Predicted Critical State Based on Invariance of the Lyapunov Exponent in Dual Spaces 基于双重空间中 Lyapunov 指数不变性的临界状态预测
IF 3.5 2区 物理与天体物理 Q1 PHYSICS, MULTIDISCIPLINARY Pub Date : 2024-01-01 DOI: 10.1088/0256-307x/41/1/017102
Tong Liu, Xu Xia
Critical states in disordered systems, fascinating and subtle eigenstates, have attracted a lot of research interests. However, the nature of critical states is difficult to describe quantitatively, and in general, it cannot predict a system that hosts the critical state. We propose an explicit criterion whereby the Lyapunov exponent of the critical state should be 0 simultaneously in dual spaces, namely the Lyapunov exponent remains invariant under the Fourier transform. With this criterion, we can exactly predict a one-dimensional quasiperiodic model which is not of self-duality, but hosts a large number of critical states. Then, we perform numerical verification of the theoretical prediction and display the self-similarity of the critical state. Due to computational complexity, calculations are not performed for higher dimensional models. However, since the description of extended and localized states by the Lyapunov exponent is universal and dimensionless, utilizing the Lyapunov exponent of dual spaces to describe critical states should also be universal. Finally, we conjecture that some kind of connection exists between the invariance of the Lyapunov exponent and conformal invariance, which can promote the research of critical phenomena.
无序系统中的临界状态是一种迷人而微妙的特征状态,吸引了大量的研究兴趣。然而,临界状态的性质很难定量描述,一般来说,无法预测承载临界状态的系统。我们提出了一个明确的标准,即临界状态的李亚普诺夫指数在对偶空间中应同时为 0,即李亚普诺夫指数在傅立叶变换下保持不变。有了这个标准,我们就能准确预测一个不具有自对偶性、但存在大量临界状态的一维准周期模型。然后,我们对理论预测进行了数值验证,并显示了临界状态的自相似性。由于计算的复杂性,我们没有对高维模型进行计算。不过,既然用李雅普诺夫指数描述扩展态和局部态是普遍的、无维的,那么利用对偶空间的李雅普诺夫指数来描述临界态也应该是普遍的。最后,我们猜想,李雅普诺夫指数的不变性与保角不变性之间存在某种联系,可以促进临界现象的研究。
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引用次数: 0
Two-body hadronic weak decays of bottomed hadrons 底层强子的二体强子弱衰变
IF 3.5 2区 物理与天体物理 Q1 PHYSICS, MULTIDISCIPLINARY Pub Date : 2023-12-29 DOI: 10.1088/0256-307x/41/2/021301
Ying Zhang, Guangzhao He, Quanxing Ye, Da-Cheng Yan, Jun Hua, Qian Wang
The structure of light diquarks plays a crucial role in the formation of exotic hadrons beyond the conventional quark model, especially in their line shapes of bottomed hadron decays. We study the two-body hadronic weak decays of bottomed baryons and bottomed mesons to probe the light diquark structure and pin down the quark-quark correlations in the diquark picture. We find that the light diquark does not favor a compact structure. For instance, the isoscalar diquark $[ud]$ in $Lambda_{b}^{0}$ can be easily split and rearranged to form $Sigma_{c}^{(*)}bar{D}^{(*)}$ via the color-suppressed transition. This provides a hint that the hidden charm pentaquark states produced in $Lambda^0_b$ decays could be the $Sigma_{c}^{(*)}bar{D}^{(*)}$ hadronic molecular candidates. This quantitative study resolves the apparent conflicts between the production mechanism and molecular nature of these $P_c$ states observed in experiment.
轻二夸克的结构在传统夸克模型之外的奇异强子的形成中起着至关重要的作用,尤其是在它们的底层强子衰变的线型中。我们研究了底层重子和底层介子的二体强子弱衰变,以探测轻二夸克结构,并确定二夸克图景中的夸克-夸克相关性。我们发现轻二夸克并不倾向于紧凑的结构。例如,$Lambda_{b}^{0}$中的等标二夸克$[ud]$可以很容易地分裂并重新排列,通过颜色抑制转变形成$Sigma_{c}^{(*)}bar{D}^{(*)}$。这就提示我们,在 $Lambda^0_b$ 衰变中产生的隐蔽粲五夸克态可能就是 $Sigma_{c}^{(*)}bar{D}^{(*)}$ 的强子分子候选态。这项定量研究解决了实验中观测到的这些$P_c$态的产生机制和分子性质之间的明显冲突。
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引用次数: 0
Modulation of high-order harmonic generation from a monolayer ZnO by co-rotating two-color circularly polarized laser fields 同向旋转双色圆偏振激光场对单层氧化锌高阶谐波产生的调制
IF 3.5 2区 物理与天体物理 Q1 PHYSICS, MULTIDISCIPLINARY Pub Date : 2023-12-22 DOI: 10.1088/0256-307x/41/1/014205
Yue Qiao, Jiaqi Chen, Shushan Zhou, Jigen Chen, Shicheng Jiang, Yu-Jun Yang
By numerically solving the two-dimensional semiconductor Bloch equation, this paper studies the high-order harmonic emission of a monolayer ZnO under the driving of co-rotating two-color circularly polarized laser pulses. By changing the relative phase between the fundamental frequency field and the second one, it is found that the harmonic intensity in the platform region can be significantly modulated. In the higher order, the harmonic intensity can be increased by about one order of magnitude. Through time-frequency analysis, it is demonstrated that the the emission trajectory of monolayer ZnO can be cotrolled by the relative phase, and the harmonic enhacment is caused by the second quantum trajectory with the higher emission probability. In addition, near-circularly polarized harmonics can be generated in the co-rotating two-color circularly polarized fields. With the change of the relative phase, the harmonics in the platform region can be altered from left-handed near-circularly polarization to right-handed one. Our results can obtain high-intensity harmonic radiation with an adjustable ellipticity, which provides an opportunity for the synthesis of circularly polarized attosecond pulses.
本文通过数值求解二维半导体布洛赫方程,研究了单层氧化锌在共旋双色圆偏振激光脉冲驱动下的高阶谐波发射。研究发现,通过改变基频场和第二基频场之间的相对相位,可以显著调制平台区的谐波强度。在高阶,谐波强度可以增加约一个数量级。通过时频分析表明,单层氧化锌的发射轨迹可以通过相对相位进行同调,谐波增强是由发射概率较高的第二量子轨迹引起的。此外,在共旋双色圆极化场中还能产生近圆极化谐波。随着相对相位的改变,平台区域的谐波可以从左旋近圆偏振变为右旋近圆偏振。我们的研究结果可以获得椭圆度可调的高强度谐波辐射,这为合成圆极化阿秒脉冲提供了机会。
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引用次数: 0
Exploring sulfur chemistry in TMC-1 with NSRT 利用 NSRT 探索 TMC-1 中的硫化学性质
IF 3.5 2区 物理与天体物理 Q1 PHYSICS, MULTIDISCIPLINARY Pub Date : 2023-12-21 DOI: 10.1088/0256-307x/41/2/029501
Wasim Iqbal, Xiaohu Li, Juan Tuo, Ryszard Szczerba, Yanan Feng, Zhenzhen Miao, Jiangchao Yang, Jixing Ge, Gleb Fedoseev, Donghui Quan, Qiang Chang, Chuan-Lu Yang, Tao Yang, Gao-Lei Hou, Yong Zhang, Xuan Fang, Xia Zhang, Fangfang Li, Rong Ma, Xiaomin Song, Zhiping Kou, Yuxuan Sun
Several studies have investigated sulfur depletion in dense cores like TMC-1, employing updated reaction networks for sulfur species to explain the missing sulfur in the gas within dense clouds. Most of these studies used a C/O ratio of 0.7 or lower. In this study, we present NSRT observations toward TMC-1 alongside results from time-dependent chemical simulations using an updated chemical network. Our findings highlight the impact of the C/O ratio on the gas-phase evolution of C2S and C3S. The simulation results show that the C/O ratio is an important parameter, playing a fundamental role in determining the gas-phase abundances of sulfur species in dense cores.
有几项研究对 TMC-1 等致密核心中的硫耗竭进行了调查,利用更新的硫物种反应网络来解释致密云内气体中缺失的硫。这些研究大多使用 0.7 或更低的 C/O 比率。在本研究中,我们在展示对 TMC-1 的 NSRT 观测结果的同时,还展示了利用更新的化学网络进行的随时间变化的化学模拟结果。我们的研究结果强调了 C/O 比率对 C2S 和 C3S 气相演变的影响。模拟结果表明,C/O比是一个重要参数,在决定致密堆芯中硫物种的气相丰度方面起着根本性的作用。
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引用次数: 0
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Chinese Physics Letters
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