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Effects of Dihuang Yinzi Decoction on Alzheimer's Disease: A Systematic Review and Meta-Analysis. 地黄印子汤治疗阿尔茨海默病疗效的系统评价和Meta分析。
IF 1.8 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2023-01-01 Epub Date: 2023-08-11 DOI: 10.1159/000531931
Zheng Zhang, Yousong Zhu, Chao Zhu, Shaochuang Li, Yuting Zhao, Jie Yang, Yali Qin, Jiangqi Hou, Junlong Zhang, Cheng Han
<p><strong>Objective: </strong>The aim of this study was to systematically evaluate the therapeutic effects of Dihuang Yinzi decoction on Alzheimer's disease (AD) and provide a medical evidence-based clinical application of traditional Chinese medicine (TCM).</p><p><strong>Methods: </strong>A comprehensive search was conducted across multiple databases, including PubMed, Embase, Cochrane Library, China National Journals Full-text Database, VIP Database for Chinese Technical Periodicals, Wan Fang database, and SinoMed database, to collect clinical randomized controlled trials of Dihuang Yinzi decoction in the treatment of AD. Strict literature screening was performed based on predefined inclusion and exclusion criteria. The Cochrane Collaboration risk of bias assessment tool and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system recommendation-level method was used to assess the quality of the included studies. Review Manager 5.4 and Stata 17 software were used for data synthesis and processing, while GRADE Profiler 3.6 software was used to evaluate the quality of evidence for outcome indicators (risk ratio, standardized mean difference, and weighted mean difference).</p><p><strong>Results: </strong>A total of 11 studies involving 798 patients met the inclusion criteria. Dihuang Yinzi decoction, whether used alone or in combination with conventional Western medicine, demonstrated superior efficacy compared to conventional Western medicine alone in improving the clinical effective rate, TCM syndrome score, activity of daily living score, Mini-Mental State Examination score, and Hasegawa Dementia Scale score in AD treatment. Furthermore, it exhibited a favorable safety profile. However, the GRADE evidence quality rating for the included studies was low.</p><p><strong>Conclusions: </strong>Dihuang Yinzi decoction, either used alone or in combination with conventional Western medicine, shows promising results in enhancing cognitive and memory functions as well as the self-care ability of patients with AD. However, the low GRADE evidence quality rating highlights the need for focused advancements in the planning and execution of clinical randomized controlled trials during future research attempts.</p><p><p><title>ZIEL</title>Ziel dieser Studie ist es, die therapeutischen Effekte von Dihuang Yinzi-Dekokt auf die Alzheimer-Krankheit systematisch zu bewerten und eine evidenzbasierte klinische Anwendung der traditionellen chinesischen Medizin (TCM) bereitzustellen.<title>Methoden</title>Es wurde eine umfassende Suche in mehreren Datenbanken, darunter PubMed, Embase, Cochrane Library, China National Journals Volltext-Datenbank, VIP Database for Chinese Technical Periodicals, Wan Fang Datenbank und SinoMed-Datenbank durchgeführt, um randomisierte, kontrollierte klinische Studien zu Dihuang Yinzi-Dekokt in der Behandlung der Alzheimer-Krankheit zu erfassen. Die strenge Literatursuche erfolgte auf Grundlage von vordefinierte
目的:系统评价地黄印子汤治疗阿尔茨海默病的疗效,为中医药临床循证应用提供依据,中文技术期刊VIP数据库、万方数据库和中药数据库,收集地黄印子汤治疗AD的临床随机对照试验。根据预先确定的纳入和排除标准进行严格的文献筛选。使用Cochrane协作偏倚风险评估工具和建议分级评估、发展和评估(GRADE)系统推荐水平方法来评估纳入研究的质量。Review Manager 5.4和Stata 17软件用于数据合成和处理,GRADE Profiler 3.6软件用于评估结果指标(风险比、标准化平均差和加权平均差)的证据质量。结果:共有11项研究涉及798名符合纳入标准的患者。地黄印子汤无论单独使用还是与传统西药联合使用,在改善AD的临床有效率、中医证候积分、日常生活活动度积分、迷你精神状态检查积分和长谷川痴呆量表积分方面均优于传统西药。此外,它表现出良好的安全性。然而,纳入研究的GRADE证据质量评级较低。结论:地黄印子汤无论是单独使用还是与常规西药联合使用,对提高AD患者的认知记忆功能和生活自理能力都有很好的疗效,低等级证据质量评级突出表明,在未来的研究尝试中,需要在临床随机对照试验的规划和执行方面取得重点进展。本研究旨在系统评价地黄印子汤治疗阿尔茨海默病的疗效,并为中医药的循证临床应用提供依据。方法在PubMed、Embase、Cochrane Library、中国国家期刊全文数据库、中国科技期刊VIP数据库、万方数据库和SinoMed数据库等多个数据库中进行全面检索,以获取地黄印子汤治疗阿尔茨海默病的随机对照临床试验。严格的文献检索是基于预先定义的纳入和排除标准。使用Cochrane的偏倚风险工具和GRADE(建议评估、发展和评估分级)系统来评估纳入研究的质量。使用Review Manager 5.4和Stata 17软件进行数据合成和处理,同时使用GRADE Profiler 3.6软件对结果指标(风险比、标准化平均差和加权平均差)的证据质量进行评估。结果共有11项研究符合入选标准,涉及798名患者。从临床总有效率、中医证候积分、日常活动积分、,迷你精神状态检查分数和Hasegawa痴呆量表在阿尔茨海默病治疗中的分数。此外,它具有良好的安全性。然而,根据GRADE,纳入研究的证据质量被归类为低。结论地黄印子汤单独或与传统西药联合应用,对改善阿尔茨海默病患者的认知记忆功能和自给自足能力有良好效果。然而,GRADE对证据质量的低评估强调了在未来的研究项目中,在随机对照临床试验的规划和执行方面需要有针对性的进一步发展。
{"title":"Effects of Dihuang Yinzi Decoction on Alzheimer's Disease: A Systematic Review and Meta-Analysis.","authors":"Zheng Zhang,&nbsp;Yousong Zhu,&nbsp;Chao Zhu,&nbsp;Shaochuang Li,&nbsp;Yuting Zhao,&nbsp;Jie Yang,&nbsp;Yali Qin,&nbsp;Jiangqi Hou,&nbsp;Junlong Zhang,&nbsp;Cheng Han","doi":"10.1159/000531931","DOIUrl":"10.1159/000531931","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The aim of this study was to systematically evaluate the therapeutic effects of Dihuang Yinzi decoction on Alzheimer's disease (AD) and provide a medical evidence-based clinical application of traditional Chinese medicine (TCM).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A comprehensive search was conducted across multiple databases, including PubMed, Embase, Cochrane Library, China National Journals Full-text Database, VIP Database for Chinese Technical Periodicals, Wan Fang database, and SinoMed database, to collect clinical randomized controlled trials of Dihuang Yinzi decoction in the treatment of AD. Strict literature screening was performed based on predefined inclusion and exclusion criteria. The Cochrane Collaboration risk of bias assessment tool and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system recommendation-level method was used to assess the quality of the included studies. Review Manager 5.4 and Stata 17 software were used for data synthesis and processing, while GRADE Profiler 3.6 software was used to evaluate the quality of evidence for outcome indicators (risk ratio, standardized mean difference, and weighted mean difference).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 11 studies involving 798 patients met the inclusion criteria. Dihuang Yinzi decoction, whether used alone or in combination with conventional Western medicine, demonstrated superior efficacy compared to conventional Western medicine alone in improving the clinical effective rate, TCM syndrome score, activity of daily living score, Mini-Mental State Examination score, and Hasegawa Dementia Scale score in AD treatment. Furthermore, it exhibited a favorable safety profile. However, the GRADE evidence quality rating for the included studies was low.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Dihuang Yinzi decoction, either used alone or in combination with conventional Western medicine, shows promising results in enhancing cognitive and memory functions as well as the self-care ability of patients with AD. However, the low GRADE evidence quality rating highlights the need for focused advancements in the planning and execution of clinical randomized controlled trials during future research attempts.&lt;/p&gt;&lt;p&gt;&lt;p&gt;&lt;title&gt;ZIEL&lt;/title&gt;Ziel dieser Studie ist es, die therapeutischen Effekte von Dihuang Yinzi-Dekokt auf die Alzheimer-Krankheit systematisch zu bewerten und eine evidenzbasierte klinische Anwendung der traditionellen chinesischen Medizin (TCM) bereitzustellen.&lt;title&gt;Methoden&lt;/title&gt;Es wurde eine umfassende Suche in mehreren Datenbanken, darunter PubMed, Embase, Cochrane Library, China National Journals Volltext-Datenbank, VIP Database for Chinese Technical Periodicals, Wan Fang Datenbank und SinoMed-Datenbank durchgeführt, um randomisierte, kontrollierte klinische Studien zu Dihuang Yinzi-Dekokt in der Behandlung der Alzheimer-Krankheit zu erfassen. Die strenge Literatursuche erfolgte auf Grundlage von vordefinierte","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"440-452"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9980966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Medical Cannabinoids as Treatment for Hypophosphatasia-Related Symptoms. 医用大麻素治疗磷酸酶减退症相关症状
IF 1.8 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2023-01-01 DOI: 10.1159/000528069
Jan Moritz Fischer, Michael Jeitler, Sarah Beverly Blakeslee, Christian Kessler

Background: Hypophosphatasia (HPP) is a rare congenital disease caused by a mutation affecting tissue nonspecific alkaline phosphatase, an enzyme involved in phosphate metabolism. The clinical manifestation usually includes bone mineralization disorders, neurological symptoms, and persistent muscle pain.

Case report: This case involves a woman in her sixties of Central European descent who suffers from lifelong chronic pain and muscle weakness due to HPP and concomitant degenerative changes of the lumbar spine. The patient is physically impaired and limited in her ability to walk as a result. HPP-specific and guideline-based multimodal pain management including enzyme replacement therapy with asfotase alfa, opioids, invasive orthopedic and neurosurgical procedures, long-term physiotherapy, and psychotherapy did not yield sufficient treatment results. The average pain was given as 8.5 on a numerical rating scale (NRS, 0-10) for the last 3 years. Treatment with a cannabidiol-predominant, full-spectrum, prescription cannabis extract led to a clinically meaningful pain reduction to 2.5/10 NRS, a discontinuation of opioids, and a recent resumption of employment as a physician.

Conclusion: A more widespread consideration of medical cannabinoids in the treatment of complex chronic pain is proposed. Cannabinoids may pose a particularly potent treatment option for HPP-related symptoms and inflammation due to their known anti-inflammatory properties.

背景:低磷酸症(HPP)是一种罕见的先天性疾病,由影响组织非特异性碱性磷酸酶(一种参与磷酸盐代谢的酶)的突变引起。临床表现通常包括骨矿化障碍、神经系统症状和持续性肌肉疼痛。病例报告:该病例涉及一名60多岁的中欧血统妇女,由于HPP和伴随的腰椎退行性改变,她终生患有慢性疼痛和肌肉无力。病人身体受损,行走能力受到限制。hpp特异性和基于指南的多模式疼痛管理,包括用asfotase α、阿片类药物、侵入性骨科和神经外科手术、长期物理治疗和心理治疗的酶替代治疗,没有产生足够的治疗效果。过去3年的平均疼痛评分为8.5分(NRS, 0-10分)。以大麻二酚为主的全谱处方大麻提取物治疗导致临床有意义的疼痛减少到2.5/10 NRS,停止使用阿片类药物,最近恢复了医生的工作。结论:医用大麻素在复杂慢性疼痛的治疗中应得到更广泛的考虑。大麻素由于其已知的抗炎特性,可能对hp相关症状和炎症提供特别有效的治疗选择。
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引用次数: 1
Evaluating "Comparing the Effects of Massage Therapy and Aromatherapy on Knee Pain, Morning Stiffness, Daily Life Function, and Quality of Life in Patients with Knee Osteoarthritis". 评估“按摩疗法和芳香疗法对膝骨关节炎患者膝关节疼痛、晨僵、日常生活功能和生活质量的影响比较”。
IF 1.8 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2023-01-01 Epub Date: 2022-01-05 DOI: 10.1159/000521783
Menghua Li, Zhaoxi Liu, Yunxuan Huang
Dear Editor, We are very happy to read this article named "Comparing the Effects of Massage Therapy and Aromatherapy on Knee Pain, Morning Stiffness, Daily Life Function, and Quality of Life in Patients with Knee Osteoarthritis" [1]. The study confirmed that massage can effectively improve the quality of life of patients with knee osteoarthritis. This provides clinicians with good health advice. We greatly appreciate the author's research. If the research design can be improved, then the research power will be stronger. The authors used simple randomization for patient assignments. Although simple randomization is inexpensive and easy to implement, it is easy to trigger imbalances in terms of important baseline[2]. Furthermore, simple randomization may lead to i=imbalances in the number of participants randomized for each group [3]. In a small samples trial, simple randomization is not a good option for the trial. Blocked randomization may be a better choice for a small sample trial, for example, this study. On the other hand, authors should report the basis for the calculation of sample size according to the CONSORT statement [4]. The authors should consider the balance between medicine and statistics, which will be a bridge of scientific study and ethical requirements. The authors did not disclose how they determined the sample size, so we cannot evaluate whether the study reached a reasonable balance.
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引用次数: 0
Dissolvable Microneedle Patch Increases the Therapeutic Effect of Jawoongo on DNCB-Induced Atopic Dermatitis in Mice. 可溶微针贴片增强紫虫虫草对dcb诱导小鼠特应性皮炎的治疗作用。
IF 1.8 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2023-01-01 DOI: 10.1159/000525451
Hye Min Jang, Haejoong Kim, Soo-Yeon Park, Eun Jin An, Chang Yub Sung, Do Hyeon Jeong, Gihyun Lee

Background: Jawoongo (JW) is a topical herbal ointment that has been used as an alternative treatment option for atopic dermatitis. Topical ointments are known to have less bioavailability because the stratum corneum allows only lipophilic and low molecular weight drugs to pass across it. This study aimed to investigate whether applying microneedle patches (MNP) increases the therapeutic effect of 2,4-dinitrochlorobenzene (DNCB)+JW for atopic dermatitis by enhancing transdermal delivery.

Methods: Atopic dermatitis was induced by DNCB in BALB/c mice. The combination treatment of JW and MNP was estimated to study the effect of MNP in improving transdermal delivery. Histological analysis, quantitative real-time PCR (qPCR), and immunofluorescence were performed to verify the effect of MNP in enhancing the therapeutic effects of DNCB+JW on atopic dermatitis in mice.

Results: Both combination treatment and DNCB+JW treatment ameliorated histological alterations and reduced skin thickness and infiltration of CD4+ T cells in atopic dermatitis-like skin lesions in DNCB-exposed BALB/c mice. However, the improvement of histological alterations was better in the combination treatment, which was almost normal. Furthermore, the combination treatment exhibited a larger decrease in mRNA levels of IL-4, IL-6, IL-13, iNOS, and TNF-α, compared to DNCB+JW only. In addition, skin thickness and infiltration of CD4+ T cells in the sensitized skin were significantly lower using the combination treatment than using DNCB+JW only.

Conclusion: Combination treatment with JW and MNP further decreased skin thickness and several inflammatory cytokines in atopic dermatitis like skin lesions compared to treatment using JW alone. These findings suggest that applying a dissolvable MNP after JW application could be useful for treating atopic dermatitis.

背景:Jawoongo (JW)是一种局部草药软膏,已被用作特应性皮炎的替代治疗选择。众所周知,局部软膏的生物利用度较低,因为角质层只允许亲脂性和低分子量药物通过。本研究旨在探讨微针贴剂(MNP)是否通过促进透皮给药来提高2,4-二硝基氯苯(DNCB)+JW对特应性皮炎的治疗效果。方法:采用DNCB诱导BALB/c小鼠特应性皮炎。估计JW与MNP联合治疗,研究MNP改善透皮给药的效果。采用组织学分析、定量实时PCR (qPCR)和免疫荧光法验证MNP增强DNCB+JW对小鼠特应性皮炎的治疗作用。结果:联合治疗和DNCB+JW治疗均能改善DNCB暴露的BALB/c小鼠特应性皮炎样皮损的组织学改变,减少皮肤厚度和CD4+ T细胞的浸润。然而,联合治疗对组织学改变的改善更好,几乎是正常的。此外,与DNCB+JW相比,联合治疗组IL-4、IL-6、IL-13、iNOS和TNF-α的mRNA水平下降幅度更大。此外,与单用DNCB+JW相比,联合治疗致敏皮肤的皮肤厚度和CD4+ T细胞浸润明显降低。结论:与单用JW治疗相比,JW与MNP联合治疗可进一步降低特应性皮炎样皮损的皮肤厚度和几种炎性细胞因子。这些发现表明,在JW应用后应用可溶性MNP可能对治疗特应性皮炎有用。
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引用次数: 0
Homeopathic Treatment of Ramsay Hunt Syndrome: A Case Report. 拉姆齐-亨特综合征的顺势疗法:病例报告
IF 1.8 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2023-01-01 Epub Date: 2023-09-01 DOI: 10.1159/000533849
Puja Bhakta, Abhijit Dutta
<p><strong>Introduction: </strong>Ramsay Hunt syndrome (RHS) is an uncommon neurological complication resulting from the reactivation of latent herpes zoster virus. The condition often presents with facial paralysis, palatal ulcers, dysphagia, and altered taste sensation, leading to reduced quality of life. Standard therapeutic options for RHS have limitations, prompting the exploration of alternative treatments with improved prognostic outcomes. This case report aims to present a noteworthy clinical observation of RHS managed with individualized homeopathic treatment, emphasizing its potential therapeutic effect.</p><p><strong>Case description: </strong>A 24-year-old female patient exhibited left-sided facial weakness, along with palatal ulcers, dysphagia, and ageusia, prompting the diagnosis of RHS. Following the principles of homeopathy, a personalized therapeutic regimen was formulated, consisting tailored administration of Rhus toxicodendron, Spigelia anthelmia, and Sulfur. The House-Brackmann scale was employed to objectively assess the severity of facial palsy, while photographic documentation tracked the progression of palatal ulcers and facial paralysis. Over a carefully monitored observation period of 14 days, the patient demonstrated notable therapeutic response. There was a significant reduction in the extent of palatal ulceration and left-sided facial palsy exhibited marked improvement. Subsequent days of follow-up witnessed a consistent amelioration of the patient's condition, substantiating the effect of the individualized homeopathic treatment.</p><p><strong>Conclusion: </strong>This case report highlights an exceptional instance of RHS recovery within a relatively short timeframe, achieved through the administration of individualized homeopathic therapy. The favorable outcomes observed in this case underscore the potential of homeopathy as a promising intervention for RHS management. Nevertheless, further systematic investigations are imperative to comprehensively evaluate the scope and applicability of homeopathy in the treatment of RHS.</p><p><p><title>Einleitung</title>Das Ramsay‐Hunt‐Syndrom (RHS) ist eine seltene neurologische Komplikation, die durch die Reaktivierung einer latenten Herpes‐Zoster‐Virusinfektion verursacht wird. Die Krankheit manifestiert sich häufig mit Gesichtslähmung, Ulcerationen am Gaumen, Dysphagie und verändertem Geschmacksempfinden und ist mit einer Einschränkung der Lebensqualität verbunden. Die Standardtherapieoptionen für RHS sind begrenzt, weshalb nach alternativen Behandlungsmöglichkeiten mit besseren prognostischen Ergebnissen gesucht wird. Im vorliegenden Fallbericht wird eine interessante klinische Beobachtung bei RHS vorgestellt, das mit individualisierter Homöopathie behandelt wurde, und deren potenzielle therapeutische Wirksamkeit wird hervorgehoben.<title>Der Fall</title>Eine 24-jährige Patientin zeigte eine linksseitige Gesichtsschwäche in Verbindung mit Ulcerationen am Gaumen, Dysphagie
导言:拉姆齐-亨特综合征(Ramsay Hunt syndrome,RHS)是一种不常见的神经系统并发症,由潜伏的带状疱疹病毒重新激活引起。该病通常表现为面瘫、腭部溃疡、吞咽困难和味觉改变,导致生活质量下降。RHS的标准治疗方案存在局限性,这促使人们探索可改善预后的替代疗法。病例描述:一名 24 岁的女性患者表现出左侧面部无力,同时伴有腭部溃疡、吞咽困难和老年性咽喉炎,因此被诊断为 RHS。根据顺势疗法的原则,制定了个性化的治疗方案,包括量身定制的毒玫瑰、刺五加和硫磺。采用 House-Brackmann 量表对面瘫的严重程度进行客观评估,同时用照片记录腭溃疡和面瘫的进展情况。经过 14 天的仔细观察,患者表现出明显的治疗反应。腭溃疡程度明显减轻,左侧面瘫也有明显改善。结论:本病例报告强调了通过个性化顺势疗法在较短时间内实现 RHS 恢复的特殊案例。本病例中观察到的良好疗效凸显了顺势疗法作为一种很有前景的治疗方法的潜力。引言拉姆塞-亨特综合征(Ramsay-Hunt Syndrome,RHS)是一种罕见的神经系统并发症,由潜伏的带状疱疹病毒感染再次激活引起。该病通常表现为面瘫、腭部溃疡、吞咽困难和味觉改变,并伴有生活质量下降。RHS的标准治疗方案有限,因此人们正在寻求预后效果更好的替代治疗方案。在本病例报告中,介绍了采用个体化顺势疗法治疗 RHS 的一个有趣的临床观察结果,并强调了其潜在的疗效。病例一名 24 岁的女性患者因左侧面部无力伴有上颚溃疡、吞咽困难和老年痴呆症而被诊断为 RHS。根据顺势疗法的原则,为患者制定了个性化的治疗方案,其中包括根据患者的具体情况服用毒性杜鹃花、刺五加和硫磺。使用 House-Brackmann 量表对面瘫的严重程度进行了客观评估,同时用照片记录了腭溃疡和面瘫的进展情况。在 14 天的仔细观察期间,患者表现出了明显的治疗反应。腭部溃疡程度明显减轻,左侧面瘫明显改善。结论本病例报告强调了一个不寻常的病例,即通过实施个性化的顺势疗法,患者在相对较短的时间内恢复了口腔颌面部溃疡。在本病例中观察到的良好结果凸显了顺势疗法作为一种治疗 RHS 的干预措施的潜力。然而,要全面评估顺势疗法在治疗 RHS 方面的范围和适用性,还需要进一步的系统研究。
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引用次数: 0
Influence of Comminution Methods and Air Exposure in the Production of Melissa officinalis Mother Tincture. 粉碎方法和空气暴露对茉莉母酊剂生产的影响。
IF 1.8 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2023-01-01 DOI: 10.1159/000528219
Didier Barmaverain, Samuel Hasler, Christoph Kalbermatten, Matthias Plath, Roger Kalbermatten

Introduction: During the processing of fresh plants, prolonged exposure to the air can cause rapid oxidative changes, and this is further accelerated if they have large surface areas. These changes can ultimately lead to losses in valuable ingredients and deterioration of the final product. Consequently, in the food, cosmetics, and pharmaceutical industries, oxidation and the use of antioxidant conservatives are major considerations during processing and production. However, similar considerations are not currently made for herbal medicines. The differences in the UV-Vis spectra of several commercial herbal mother tinctures were investigated here to determine if the oxidation process occurred and should thus be considered during their production.

Methods: The impact of air exposure on comminuted fresh Melissa officinalis and on the quality of the resulting mother tincture was evaluated using UV-Vis spectrophotometric analysis, antioxidant tests (potassium permanganate and FOLIN-Ciocalteu), and high-performance thin-layer chromatography.

Results: A time-dependent decrease in phenolic compounds, UV absorbance, and antioxidant capacity of the Melissa officinalis mother tincture were observed. Specifically, the antioxidant capacity of ground Melissa officinalis in the resulting herbal mother tincture was reduced by 40.47% and 55.52% after 5 and 30 min of air exposure, respectively.

Conclusions: The results indicate that the Melissa officinalis mother tincture is affected if its comminuted starting material is exposed to air during the manufacturing process and that this should be considered when producing fresh herbal medicine plant products in the future.

在新鲜植物的加工过程中,长时间暴露在空气中会导致快速的氧化变化,如果它们的表面积很大,这种氧化变化会进一步加速。这些变化最终会导致有价值成分的损失和最终产品的变质。因此,在食品、化妆品和制药工业中,氧化和抗氧化剂的使用是加工和生产过程中的主要考虑因素。然而,目前还没有对草药进行类似的考虑。本文研究了几种商业草药母酊剂的紫外可见光谱差异,以确定是否发生了氧化过程,从而在生产过程中应考虑氧化过程。方法:采用紫外-可见分光光度法、抗氧化试验(高锰酸钾试验和福林- ciocalteu试验)和高效薄层色谱法评价空气暴露对新鲜茉莉粉及其母酊剂质量的影响。结果:梅丽莎母酊剂的酚类化合物含量、紫外吸光度和抗氧化能力呈时间依赖性下降。实验结果表明,经5 min和30 min的空气暴露后,沙蚕母酊剂的抗氧化能力分别下降了40.47%和55.52%。结论:实验结果表明,Melissa officinalis母酊剂的粉碎原料在生产过程中暴露在空气中会对其产生影响,在今后生产新鲜植物药材产品时应予以考虑。
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引用次数: 0
Effects of Transcutaneous Electrical Nerve Stimulation on Chronic Pelvic Pain in Women: A Systematic Review and Meta-Analysis. 经皮神经电刺激对女性慢性盆腔疼痛的影响:一项系统回顾和荟萃分析。
IF 1.8 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2023-01-01 DOI: 10.1159/000528133
Seyedeh Saeideh Babazadeh-Zavieh, Siamak Bashardoust Tajali, Seyed Mohammad Jafar Haeri, Amirhossein Shamsi

Introduction: The study aimed to identify the effects of transcutaneous electrical nerve stimulation (TENS) in women with chronic pelvic pain (CPP) by conducting a systematic review and meta-analysis of randomized controlled trials.

Methods: We used five international databases from 2000 to 2020 and selected the clinical trials that reported the effects of TENS on CPP. We excluded the case reports, acute pelvic pain reports, men-related, animal-related, and intravaginal and intrarectal electrical stimulation articles. The level of pain (based on the visual analog scale) was considered for pooling data through the meta-analysis.

Results: Ten studies met the inclusion criteria, and three articles were included in the meta-analysis. The results showed that TENS application mildly reduced pain in women with primary dysmenorrhea (mean difference = -1.29; 95% CI: -2.57 to -0.01; Z = 1.98, p = 0.05). Also, to reduce pain in patients with CPP, the TENS must be applied at least for 20 min, with a pulse duration of 50-400 μs, at a frequency of 2-120 Hz. The meta-analysis was followed by assessing the risk of bias, including publication bias. Based on the Cochrane risk of bias evaluation, the majority of the included trials were assessed with moderate methodological quality.

Conclusion: TENS application can mildly improve the level of pain in patients with CPP caused by primary dysmenorrhea. Although no distinct agreement was observed among the effective parameters, the high-frequency mode with maximum tolerated intensity was more effective compared to the low-frequency mode.

前言:本研究旨在通过对随机对照试验的系统回顾和荟萃分析,确定经皮神经电刺激(TENS)对女性慢性盆腔痛(CPP)的影响。方法:使用2000年至2020年的5个国际数据库,选择报道TENS对CPP影响的临床试验。我们排除了病例报告、急性盆腔疼痛报告、男性相关、动物相关以及阴道内和直肠内电刺激的文章。通过荟萃分析,考虑疼痛水平(基于视觉模拟量表)以汇集数据。结果:10项研究符合纳入标准,3篇文章被纳入meta分析。结果显示,应用TENS可轻度减轻原发性痛经妇女的疼痛(平均差值= -1.29;95% CI: -2.57 ~ -0.01;Z = 1.98, p = 0.05)。此外,为了减轻CPP患者的疼痛,脉冲持续时间至少为20分钟,脉冲持续时间为50-400 μs,频率为2-120 Hz。荟萃分析之后评估偏倚风险,包括发表偏倚。根据Cochrane偏倚风险评价,大多数纳入的试验的方法学质量评价为中等。结论:应用TENS可轻度改善原发性痛经所致CPP患者的疼痛程度。虽然有效参数之间没有明显的一致性,但具有最大容忍强度的高频模式比低频模式更有效。
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引用次数: 0
Effectiveness of Eupatorium perfoliatum 30C in Prevention of Dengue Fever and Acute Febrile Illness during 2017 Dengue Outbreak in Urban Slums of Delhi: A Prospective, Open-Label, Community-Based, Parallel Cohort Study. 枯叶泽兰30C在2017年德里城市贫民窟登革热暴发期间预防登革热和急性发热性疾病的有效性——一项前瞻性、开放标签、基于社区的平行队列研究
IF 1.8 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2023-01-01 Epub Date: 2023-11-10 DOI: 10.1159/000534461
Debadatta Nayak, Ruchika Bhalla, Rupali Bhalerao, Lovepreet Kaur, Ankit Gupta, Vanee Dev, Smita Singh, Anil Khurana, Raj Kumar Manchanda
<p><strong>Objective: </strong>This study was undertaken to assess the effectiveness of Eupatorium perfoliatum (EP) 30C on the incidence of dengue fever and acute febrile illness (AFI) during the 2017 dengue outbreak.</p><p><strong>Methods: </strong>We conducted a prospective, open-label, community-based parallel cohort study involving apparently healthy individuals residing in 06 urban slums (JJ colony) of Delhi. The participants were enrolled in two cohorts - the medicine cohort (MC) and the control cohort (CC). Participants in MC were given weekly one dose of EP 30C for 10 weeks along with Information, Education and Communication (IEC) material regarding dengue. Participants in the CC were provided with the IEC material only. The primary outcome measure was the incidence of dengue fever as per case definitions notified in the national guidelines for clinical management of dengue fever by the Government of India during the 10 weeks follow-up period. The secondary outcome measures were the incidence of AFI and the hospitalization of confirmed dengue cases.</p><p><strong>Results: </strong>The analysis included 40,769 participants residing in 06 slum clusters of Delhi out of which 28,321 participants were in MC and 12,448 participants were in CC. The incidence of laboratory-confirmed dengue in the MC was 2.57 per 10,000 person-weeks (95% confidence interval [CI], 2.02-3.22) in comparison with 7.55 per 10,000 person-weeks (95% CI, 6.12-9.21) in the CC. The incidence of AFI in the MC was 19.66 per 10,000 person-weeks (95% CI, 18.07-21.36) in comparison with 40.96 per 10,000 person-weeks (95% CI, 37.48-44.67) in the CC. The overall protective effect of EP against laboratory-confirmed dengue was 65.77% (95% CI, 53.37-74.87; p = 0.0001) and against AFI was 52.58% (95% CI, 46.37-58.07; p = 0.0001). Hospitalization reported in the MC was nil as against 4.35% in the CC. No dengue-related case fatalities were reported from either cohort. None of the participants from the MC reported any adverse events owing to the prophylactic intervention.</p><p><strong>Conclusion: </strong>The study concludes that EP 30C was able to prevent dengue significantly. Randomized controlled trials are needed to confirm or refute our findings.</p><p><p><title>Ziel</title>Das Ziel dieser Studie war die Beurteilung der Wirksamkeit von <italic>Eupatorium perfoliatum</italic> (EP) 30C auf die Inzidenz von Dengue-Fieber und akuter fiebriger Erkrankung (AFE) während des Dengue-Ausbruchs 2017.<title>Methoden</title>Wir führten eine prospektive, unverblindete, Bevölkerungs-Parallelgruppen-Kohortenstudie mit augenscheinlich gesunden Bewohnern von 6 städtischen Slums (JJ-Kolonie) in Delhi durch. Die Teilnehmer wurden in 2 Kohorten aufgenommen, einer Medizinkohorte (MK) und einer Kontrollkohorte (KK). Die Teilnehmer in der MK erhielten 10 Wochen lang wöchentlich eine Dosis EP 30C und dazu Aufklärungsmaterialien über Dengue. Die Teilnehmer in der KK erhielten nur die Aufklärungsmaterialien.
目的评价peropatorium perfoliatum (EP) 30C在2017年登革热暴发期间对登革热和急性发热性疾病(AFI)发病率的影响。方法我们进行了一项前瞻性、开放标签、基于社区的平行队列研究,纳入了居住在德里06个城市贫民窟(JJ殖民地)的表面健康个体。参与者被分为两个队列——药物队列(MC)和对照队列(CC)。MC参与者每周服用一剂ep30c,持续10周,同时服用有关登革热的信息、教育和传播(IEC)材料。委员会的与会者只获得了独立选举委员会的材料。主要结果衡量指标是在10周随访期间,根据印度政府在《登革热临床管理国家指南》中通报的病例定义,登革热发病率。次要结局指标是AFI的发生率和确诊登革热病例的住院率。结果分析了居住在德里06个贫民窟群的40,769名参与者,其中28,321名参与者为MC, 12,448名参与者为CC. MC的实验室确诊登革热发病率为2.57 / 10,000人周(95%置信区间[CI], 2.02至3.22),而CC的发病率为7.55 / 10,000人周(95% CI, 6.12至9.21)。18.07 ~ 21.36),而CC为40.96例(95% CI, 37.48 ~ 44.67)。EP对实验室确诊登革热的总体保护效果(PE)为65.77% (95% CI, 53.37 ~ 74.87;p = 0.001),与AFI的比值为52.58% (95% CI, 46.37 ~ 58.07;P = 0.0001)。MC报告的住院率为零,而CC报告的住院率为4.35%。两个队列均未报告与登革热有关的死亡病例。没有来自MC的参与者报告由于预防性干预而发生任何不良事件。结论peropiatum 30C对登革热有明显的预防作用。需要随机对照试验来证实或反驳我们的发现。
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引用次数: 0
The Effect of Yoga on Maternal Anxiety in Women with Excessive Gestational Weight Gain: A Randomized Controlled Trial. 瑜伽对孕期体重过度增加的孕妇焦虑的影响:一项随机对照试验。
IF 1.8 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2023-01-01 Epub Date: 2023-11-15 DOI: 10.1159/000534776
Tuqa Jalal Jumaah, Shahla Faal Siahkal, Zahra Behboodi Moghadam, Elham Ebrahimi
<p><strong>Background: </strong>Excessive gestational weight gain (EGWG) and anxiety are comorbid conditions that increase the risk of adverse maternal and neonatal outcomes. This study was conducted to investigate the effect of yoga on the anxiety of women with EGWG.</p><p><strong>Materials and methods: </strong>This randomized controlled trial was performed on EGWG pregnant women referring to comprehensive health centers in Qom city, Iran, between October 2021 and August 2022. Eighty-eight participants were assigned to the intervention (N = 44) and control (N = 44) groups. The experimental group participated in six sessions of 90-min yoga classes, and the control group only received routine care. Two questionnaires including a demographic information questionnaire and the State-Trait Anxiety Inventory (STAI) questionnaire were used for data collection. Data were analyzed using SPSS software version 22.</p><p><strong>Results: </strong>The results of this study showed a statistically significant difference between the two groups in terms of trait anxiety (25.84 ± 3.45 vs. 57.38 ± 8.07; p < 0.05) and state anxiety (27.93 ± 3.72 vs. 60.13 ± 8.13; p < 0.05) after intervention. On the other hand, the trait and state anxiety rates were stable in the experimental group before and after intervention, while they increased to the severe form of anxiety in the control group (effect size = -21.84 ± 10.66 vs. -19.43 ± 8.44).</p><p><strong>Conclusion: </strong>The result of this study showed that yoga has a positive effect on the anxiety of pregnant women with EGWG and can be used as a preventive or complementary solution to control the anxiety of these mothers.</p><p><p><title>Hintergrund</title>Exzessive Gewichtszunahme in der Schwangerschaft (EGWG) und Angst sind Komorbiditäten, die das Risiko für einen ungünstigen Verlauf für Mutter und Kind erhöhen. Diese Studie wurde durchgeführt, um die Auswirkung von Yoga auf Angst bei Frauen mit exzessiver Gewichtszunahme in der Schwangerschaft zu untersuchen.<title>Material und Methoden</title>Diese randomisierte, kontrollierte Studie wurde bei Schwangeren mit EGWG durchgeführt, die sich zwischen Oktober 2021 und August 2022 an Zentren für ganzheitliche Gesundheit in der Stadt Ghom im Iran vorstellten. 88 Teilnehmerinnen wurden einer Interventions- (<italic>N</italic> = 44) und einer Kontrollgruppe (<italic>N</italic> = 44) zugeteilt. Die experimentelle Gruppe nahm an einem Yogakurs von sechsmal 90 minuten Dauer teil, die Kontrollgruppe erhielt lediglich die Standardversorgung. Die Datenerhebung erfolgte mit zwei Fragebögen: einem Fragebogen zu demografischen Angaben und dem State-Trait-Angstinventar (STAI). Die Auswertung der Daten erfolgte mit SPSS-Software, Version 22.<title>Ergebnisse</title>Die Ergebnisse dieser Studie zeigten einen statistisch signifikanten Unterschied zwischen beiden Gruppen im Hinblick auf Eigenschaftsangst (25.84 ± 3.45 vs. 57.38 ± 8.07; <italic>p</italic> < 0.05) und Zustandsangst
背景:妊娠期体重增加过多(EGWG)和焦虑是增加孕产妇和新生儿不良结局风险的合并症。本研究旨在探讨瑜伽对孕期过度增重女性焦虑的影响。材料和方法本随机对照试验于2021年10月至2022年8月在伊朗库姆市综合保健中心进行的EGWG孕妇进行。88名参与者被分为干预组(N=44)和对照组(N=44)。实验组参加六节90分钟的瑜伽课,对照组只接受常规护理。采用人口统计信息问卷和状态-特质焦虑量表(STAI)两份问卷进行数据收集。数据采用SPSS软件22进行分析。结果两组患者特质焦虑得分差异有统计学意义(25.84±3.45∶57.38±8.07;p
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引用次数: 0
Bioenergy Treatment for Improving Well-Being: A Meta-Analysis. 生物能源治疗改善幸福感:一项荟萃分析。
IF 1.8 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2023-01-01 DOI: 10.1159/000529339
Harald Walach, Peter Marmann

Background: Bioenergy treatment devices for self-treatment with the aim to improve well-being are widely available, have become popular, and are used by a rather large number of persons. Yet, a systematic analysis of the assumed effect of these devices has not yet been conducted. We meta-analyzed eight very similar studies of the Healy device to assess the joint effect size.

Method: Eight studies with similar designs, some active controlled and some wait-list controlled, testing the Healy bioenergy device, were meta-analyzed. They were conducted by the producer of the device for quality assurance and further development of the application. An additional literature search revealed no additional, independent studies.

Result: The overall effect size across studies, combining all active arms and averaging outcome measures, is Hedge's g = 0.757 (random effects model, I2 = 85.8; z = 6.57; p < 0.0001). The stronger active intervention against control yields a heterogeneous g = 0.825 (random effects, I2 = 82.5; z = 7.77; p < 0.0001). Active treatments against each other result in a significant g = 0.29 (fixed effects, I2 = 0.0; z = 8.34; p < 0.0001).

Discussion: The highest effect sizes are produced by a measure of coherence, followed by the WHO5 well-being questionnaire, the Perceived Stress Scale, with the Measure Your Own Medical Outcome Profile, resulting in the smallest effect size. Heterogeneity can be partially explained by the type of control, with active control producing smaller and wait-list control producing larger outcomes. Another source of heterogeneity is the sequencing of studies. Effect sizes grew for three studies, which were similar, and then fell and remained very similar for the rest of the studies. A limitation of this analysis is the fact that all studies were conducted by the R and D Department of the producer of the device.

Conclusion: In this meta-analysis, the Healy device showed considerable effects, improving general well-being in healthy individuals. Nonetheless, an independent confirmation of these findings would be desirable. Moreover, the potential mechanisms of effect of the bioenergy device remain unclear, and further studies addressing this research question are warranted.

背景:以改善健康为目的的自我治疗的生物能源治疗装置广泛可用,已经变得流行,并被相当多的人使用。然而,还没有对这些装置的假设效果进行系统的分析。我们荟萃分析了8项非常相似的Healy器械研究,以评估关节效应大小。方法:对8项设计相似的Healy生物能源装置试验进行meta分析,其中部分为主动对照,部分为候补对照。这些测试是由设备生产商进行的,以保证质量和进一步开发应用程序。一项额外的文献检索显示没有额外的独立研究。结果:综合所有活动组和平均结果测量,各研究的总体效应大小为Hedge’s g = 0.757(随机效应模型,I2 = 85.8;Z = 6.57;P < 0.0001)。较强的主动干预对对照产生异质性g = 0.825(随机效应,I2 = 82.5;Z = 7.77;P < 0.0001)。主动处理相互对抗的结果显著g = 0.29(固定效应,I2 = 0.0;Z = 8.34;P < 0.0001)。讨论:一致性测量产生的效应量最大,其次是世卫组织5幸福问卷、感知压力量表和测量您自己的医疗结果概况,产生的效应量最小。异质性可以部分解释为控制类型,主动控制产生较小的结果,而等待列表控制产生较大的结果。异质性的另一个来源是研究的顺序。在三个相似的研究中,效应量增加,然后在其他研究中下降并保持非常相似。这一分析的一个局限性是,所有的研究都是由设备生产商的研发部门进行的。结论:在这项荟萃分析中,Healy装置显示出相当大的效果,改善了健康个体的总体幸福感。尽管如此,对这些发现的独立证实是可取的。此外,生物能源装置的潜在作用机制尚不清楚,需要进一步研究解决这一研究问题。
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引用次数: 0
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Complementary Medicine Research
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