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The Tibetan Formula Cong zhi 6 in the ORL (ENT) Practice: Experiences with Laryngopharyngeal Reflux. 藏方从治六在喉喉科(耳鼻喉科)实践中的应用:治疗喉咽反流(LPR)的体会。
IF 1.8 4区 医学 Q2 Medicine Pub Date : 2024-01-01 Epub Date: 2023-11-11 DOI: 10.1159/000534212
Barbara Friederike Zürcher

Background: Laryngopharyngeal reflux (LPR) is a frequent condition; in European countries, the prevalence can be estimated as 10-30% of the general population. Treatment includes lifestyle measures and highly dosed proton pump inhibitors (PPIs) over at least 4 weeks. However, PPIs are not unproblematic due to their potential side effects and the known phenomenon of rebound acid hypersecretion. Cong zhi 6 is a multi-herbal Tibetan formula additionally containing calcium carbonate and is available in several European countries as a food supplement Padma Aciben/Padma AciTib.

Case report: Ten patients with LPR took Cong zhi 6. The course of the complaints was documented, and the data were retrospectively analysed. Clinical symptoms as assessed with the Reflux Symptom Index (RSI) questionnaire and the findings in laryngoscopy with the Reflux Finding Score (RFS) both showed marked improvement of several symptoms. The number of patients with pathological LPR sum score was significantly reduced from 8 to 2 patients and from 10 to 1 patient in RSI and RFS, respectively. The mean sum scores were reduced from 18.1 to 8.4 (RSI) and from 12.9 to 4.4 (RFS), respectively. Also, other gastrointestinal symptoms, such as abdominal pain, bloating, feeling of fullness, and nausea, which are usually associated with functional dyspepsia and irritable bowel syndrome, were markedly improved (reduction of mean score of the 3 most frequent symptoms by 77-87%).

Conclusion: Standard medical treatment for LPR consists in high dosed PPI for at least 4 weeks, which is known for several side effects and does not treat reliable the nonacid component of LPR of pepsin or other gastric enzymes. Therefore, other medical treatment options are urgently needed. The promising data of this case series suggest that the Tibetan herbal formula Cong zhi 6 may be a treatment option in LPR and related gastrointestinal symptoms and warrant further research.

HintergrundDer laryngopharyngeale Reflux (LPR) ist eine häufige Erkrankung. In europäischen Ländern wird die Prävalenz in der Gesamtbevölkerung auf 10–30% geschätzt. Die Behandlung beinhaltet Ernährungs- und Verhaltensänderung sowie die Gabe hochdosierter Protonen-Pumpen-Hemmer (PPI) über mindestens 4 Wochen. PPI sind jedoch aufgrund ihrer hohen potenziellen Nebenwirkungen und des bekannten Rebound-Phänomens der sauren Magensafthypersekretion nicht unproblematisch. Cong zhi 6 ist eine tibetische Rezeptur aus einem Vielpflanzengemisch sowie zusätzlich Calciumcarbonat und ist in einigen europäischen Ländern als Nahrungsergänzungsmittel Padma Aciben/Padma AciTib erhältlich.Case ReportZehn Patienten mit laryngo-pharyngealem Reflux (LPR) nahmen Cong zhi 6 ein. Der Beschwerdeverlauf wurde dokumentiert und die Daten retrospektiv analysiert. Die klinischen Symptome, die mithilfe des Reflux Symptom Index (RSI) Fragebogens erfasst wurden und die mi

背景:喉咽反流(LPR)是一种常见的疾病,估计患病率为10-30%。治疗包括生活方式措施和高剂量质子泵抑制剂(PPI)至少4周。然而,由于其潜在的副作用和已知的反跳酸分泌过多的现象,PPI并非没有问题。聪芝是一种藏式复方草药,另外含有碳酸钙,在一些欧洲国家作为食品补充剂可以买到。病例报告:喉咽反流(LPR)患者10例。对投诉过程进行记录,并对数据进行回顾性分析。用反流症状指数(RSI)问卷评估的临床症状和用反流发现评分(RFS)进行喉镜检查的结果都显示了一些症状的显著改善。RSI组病理LPR总评分从8例减少到2例,RFS组从10例减少到1例。平均和评分分别从18.1分(RSI)和12.9分(RFS)降至8.4分和4.4分。此外,通常与功能性消化不良和肠易激综合征相关的其他胃肠道症状,如腹痛、腹胀、饱腹感和恶心均明显改善(3种最常见症状的平均评分降低77-87%)。结论:LPR的标准药物治疗包括高剂量PPI,持续至少4周,这是已知的几种副作用,并且不能可靠地治疗LPR的胃蛋白酶或其他胃酶的非酸成分。因此,迫切需要其他医疗选择。本病例系列的数据表明,藏药复方聪栀6可能是治疗LPR及相关胃肠道症状的一种有价值的选择。
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引用次数: 0
How Physicians and Nursing Staff Perceive Effectiveness and Tolerability of Bryophyllum Preparations: An Online Survey in an Anthroposophic Hospital. 医生和护理人员如何看待金银花制剂的有效性和耐受性:一家人类医院的在线调查。
IF 1.8 4区 医学 Q2 Medicine Pub Date : 2024-01-01 Epub Date: 2024-01-06 DOI: 10.1159/000536015
Tiffany Huber, Daniel Krüerke, Ana Paula Simões-Wüst

Background: Bryophyllum preparations are widely used in anthroposophic medicine, most often for mental and behavioural disorders. Three prospective studies have revealed positive effects of Bryophyllum pinnatum on sleep quality, and various trials have shown very good tolerability. Results from animal models have indicated CNS depressant and anxiolytic effects. This survey was conducted at the hospital "Klinik Arlesheim" in Switzerland to find out how the physicians and the nursing staff perceive the effectiveness and the tolerability of the Bryophyllum preparations they most frequently use.

Design: Internal, anonymous online survey of healthcare professionals (April 8-May 31, 2022). The questionnaire comprised 105 multiple-choice questions. Answering the questions was taken as consent to participate in the survey.

Participants and methods: All physicians and nursing staff with a valid email address at the hospital "Klinik Arlesheim AG" were invited via email to participate in this REDCap survey. The data were analysed descriptively.

Results: Out of 266 invited participants, 48 answered some and 36 answered all questions (response rate between 18.0% and 13.5%). The participants had long experience with Bryophyllum preparations and were comprised approximately equal numbers of physicians and nursing staff. Various Bryophyllum preparations from the hospital's own production and Wala Heilmittel GmbH (in both cases produced from the species B. daigremontianum) and from Weleda AG (species B. pinnatum) were used. The indications for which most participants had prescribed or administered Bryophyllum preparations "very frequently" were anxiety, sleep disorders, crisis situations in oncology, posttraumatic stress disorder, benzodiazepine dependence/withdrawal, and depression. Improvements such as relief from restlessness, decreased anxiety, balance, easier falling asleep, better sleeping through, increased resilience, mood elevation, and less urge to move one's legs were reported "frequently" or "very frequently." Almost all participants agreed that Bryophyllum can be used to reduce the intake of synthetic sedatives or psychotropic drugs, but only approximately half believed that it could replace them. The majority of participants mentioned good tolerability of the various products, but a few reported occasional stomach or intestinal irritation, daytime fatigue, drowsiness, diarrhoea, and nausea.

Conclusion: Bryophyllum preparations are perceived as helpful in the treatment of various mental disorders, particularly anxiety, and are generally well tolerated. Most of these preparations are used for indications that have not yet been clinically investigated.

HintergrundBryophyllum-Präparate werden in der Anthroposophischen Medizin sehr häufig zur Behandlung von psychischen und Verhaltensstörungen eingesetzt.

背景:睡茄制剂在人类医学中被广泛使用,最常用于治疗精神和行为障碍。三项前瞻性研究显示,羽叶甘草对睡眠质量有积极影响,各种试验也表明其耐受性非常好。动物模型的研究结果表明,它具有抑制中枢神经系统和抗焦虑的作用。这项调查是在瑞士的 "Klinik Arlesheim "医院进行的,目的是了解医生和护理人员如何看待他们最常用的红景天制剂的有效性和耐受性:设计:对医护人员进行内部匿名在线调查(2022年4月8日至5月31日)。问卷由 105 道选择题组成。回答问题即视为同意参与调查:我们通过电子邮件邀请 "Klinik Arlesheim AG "医院所有拥有有效电子邮件地址的医生和护理人员参与此次 REDCap 调查。对数据进行了描述性分析:在266名受邀参与者中,48人回答了部分问题,36人回答了所有问题(回答率介于18.0%和13.5%之间)。参与者都有长期使用白藓皮制剂的经验,其中医生和护理人员的人数大致相当。参试者使用了医院自产和 Wala Heilmittel GmbH 公司生产的各种叶枯素制剂(两种制剂均为 B. daigremontianum 品种),以及 Weleda AG 公司生产的各种叶枯素制剂(B. pinnatum 品种)。大多数参与者 "经常 "处方或使用茶树制剂的适应症是焦虑症、睡眠障碍、肿瘤危机情况、创伤后应激障碍、苯二氮卓类药物依赖/戒断和抑郁症。"经常 "或 "非常频繁 "报告的改善情况包括:缓解烦躁不安、减少焦虑、保持平衡、更容易入睡、睡得更香、复原力增强、情绪高涨、腿部活动的冲动减少。几乎所有参与者都认为茶树叶可以用来减少合成镇静剂或精神药物的摄入量,但只有大约一半的人认为茶树叶可以替代这些药物。大多数参与者提到各种产品具有良好的耐受性,但也有少数人表示偶尔会出现胃肠不适、白天疲劳、嗜睡、腹泻和恶心等症状:结论:人们认为叶枯素制剂有助于治疗各种精神疾病,尤其是焦虑症,而且一般都能很好地耐受。这些制剂大多用于尚未进行临床研究的适应症。
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引用次数: 0
Use of Complementary and Alternative Medicine by Patients Treated for Systemic Lupus Erythematosus, Primary Sjögren's Syndrome, or Systemic Sclerosis in a French Rural Region. 法国农村地区接受系统性红斑狼疮、原发性斯约格伦综合征或系统性硬化症治疗的患者使用补充和替代医学的情况。
IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-01-01 Epub Date: 2024-02-12 DOI: 10.1159/000536580
Florence Couillard, Simon Parreau, Stéphanie Dumonteil, Nina Ratti, Sylvain Palat, Holy Bezanahary, Eric Liozon, Kim-Heang Ly, Anne-Laure Fauchais, Guillaume Gondran
<p><strong>Background: </strong>Complementary and alternative medicine (CAM) is composed of a wide range of interventions and frequently used in parallel with conventional medicine. The aim of this study was to assess the prevalence, modalities, and association factors of CAM utilization in patients treated for systemic lupus erythematosus, primary Sjögren's syndrome, or systemic sclerosis.</p><p><strong>Patients and methods: </strong>This was a prospective single-center observational study conducted in a French university hospital center. Inclusion criteria were patients followed for systemic lupus erythematosus, primary Sjögren's syndrome, or systemic sclerosis. Data were collected with a survey which assessed sociodemographic, disease characteristics, CAM use details, life quality, and anxiety score.</p><p><strong>Results: </strong>A total of 121 patients were included, mostly women (87%), with an average age of 56 years. Proportion of patients seeking CAM was 55%. A total of 186 CAM interventions were recorded: most common were osteopathy, homeopathy, and acupuncture. Patients were looking for well-being (22%), reducing their fatigue (18%) and pain (33%). Concerning physical and mental feeling after CAM use, a subjective improvement was reported in 89% of cases. In multivariate analysis, CAM use by patient was associated with these 3 variables: coming from a Western culture, being professionally active, and having a poor quality of life and anxiety scores.</p><p><strong>Conclusion and outlook: </strong>This is the first study to focus on CAM use in patients followed for three AID in a French rural region. The current challenge is to enrich conventional medicine with CAM that is effective and safe through supervised programs to move toward an integrative medicine.</p><p><p><title>Hintergrund</title>Die Komplementär- und Alternativmedizin (CAM) umfasst ein breites Spektrum an Interventionen und wird häufig parallel zur konventionellen Medizin angewendet. Das Ziel dieser Studie war die Beurteilung der Prävalenz, Modalitäten und Assoziationsfaktoren der CAM-Anwendung bei Patienten, die wegen systemischem Lupus erythematodes, primärem Sjögren-Syndrom oder systemischer Sklerose behandelt werden.<title>Patienten und Methoden</title>Es handelte sich um eine prospektive monozentrische Beobachtungsstudie, die an einem französischen Universitätsklinikum durchgeführt wurde. Eingeschlossen wurden Patienten, die dort wegen systemischem Lupus erythematodes, primärem Sjögren-Syndrom oder systemischer Sklerose in Behandlung waren. Die Datenerhebung erfolgte mittels eines Fragebogens, der soziodemografische Merkmale, Krankheitsmerkmale, Einzelheiten der CAM-Anwendung, Lebensqualität- und Angst-Scores umfasste.<title>Ergebnisse</title>Insgesamt wurden 121 Patienten randomisiert, überwiegend Frauen (87%); das Durchschnittsalter betrug 56 Jahre. Der Anteil der Patienten, die CAM wünschten, betrug 55%. Insgesamt 186 CAM-Interventionen wurden erfasst; am häufigsten
背景:补充和替代医学(CAM)由多种干预措施组成,经常与传统医学并行使用。本研究旨在评估系统性红斑狼疮、原发性斯约格伦综合征或系统性硬化症患者使用 CAM 的流行率、方式和相关因素:这是一项在法国一所大学医院中心进行的前瞻性单中心观察研究。纳入标准为系统性红斑狼疮、原发性斯约格伦综合征或系统性硬化症患者。通过调查收集数据,评估社会人口学、疾病特征、使用 CAM 的详情、生活质量和焦虑评分:共纳入 121 名患者,其中大部分为女性(87%),平均年龄为 56 岁。寻求 CAM 的患者比例为 55%。共记录了 186 项 CAM 干预:最常见的是骨疗法、顺势疗法和针灸。患者希望获得健康(22%)、减轻疲劳(18%)和疼痛(33%)。关于使用 CAM 后的身心感受,89% 的病例报告了主观上的改善。在多变量分析中,患者使用 CAM 与以下 3 个变量有关:来自西方文化、从事职业活动、生活质量差和焦虑评分:这是第一项关注法国农村地区三种艾滋病患者使用 CAM 的研究。目前面临的挑战是,如何通过监督计划,用有效、安全的 CAM 来丰富传统医学,向综合医学迈进。
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引用次数: 0
Effectiveness of Mud-Pack Therapy and Mud-Bath Therapy in Osteoarthritis: A Systematic Review. 泥包法和泥浴法治疗骨关节炎的疗效观察。系统回顾。
IF 1.8 4区 医学 Q2 Medicine Pub Date : 2024-01-01 Epub Date: 2023-11-24 DOI: 10.1159/000535437
Gerrit Steffen Maier, Gilbert Rosar, Günther Dietz, Norbert Hemken, Konstantinos Kafchitsas, Jörn Bengt Seeger, Konstantin Horas

Objectives: Osteoarthritis has a tremendous socioeconomic impact in terms of drug spending, hospital admissions, work productivity, and temporary or permanent incapacity. Mud therapy has been discussed as potential conservative treatment options for osteoarthritis. However, findings from several trials still remain controversial. For this reason, we aimed to systematically review the highest evidence provided by published trials to estimate the clinical effect of mud-pack and mud-bath therapy for the treatment of osteoarthritis.

Methods: We searched PubMed, PEDro, and the Cochrane CENTRAL Register for Controlled Trials for articles published between 2000 and 2020 using the terms "orthopedics," "orthopaedics," "musculoskeletal," "osteoarthritis," and "mud bath," "mud pack."

Results: Of the 19 studies included, 15 examined the effects of mud-bath therapy in knee osteoarthritis treatment. One study focused on the treatment effect of mud bath on hand osteoarthritis, another study examined treatment effects in hip and knee osteoarthritis, and two studies enrolled patients with chronic low back pain caused by lumbar spine osteoarthritis. We systematically reviewed the data obtained from the literature and summarized the results on the basis of the main outcomes. The results show significant improvements in function, quality of life, and perceived pain for patients with osteoarthritis.

Conclusion: Results of randomized controlled trials suggest that mud therapy is part of a promising integrated and synergistic multidisciplinary approach in combination with other treatment forms like pharmacotherapy or physiotherapy.

ZieleDie sozio-ökonomischen Auswirkungen der Arthrose sind immens. Heiltorfbehandlungen sind seit einiger Zeit als mögliche Ergänzung der konservativen Therapieoptionen dieser Erkrankung Gegenstand wissenschaftlicher Untersuchungen. Ziel dieser Studie war es, die aktuellen Erkenntnisse zur Heiltorftherapie bei Arthrose zusammenzufassen.MethodenWir führten eine systematische Literaturrecherche der Datenbanken Pubmed, PEDro und Cochrane CENTRAL Register of Controlled Trials durch. Hierbei wurden Artikel, die zwischen 2000 und 2020 publiziert wurden und mit den Schlagwörtern “orthopedics”, “orthopaedics”, “musculoskeletal”, “osteoarthritis” und “mud-bath”, “mud-pack” assoziiert waren, erfasst.ErgebnisseVon den 19 näher untersuchten Studien beschäftigten sich 15 mit den Effekten der Heiltorftherapie bei Patienten mit Kniearthrose, eine Studie untersuchte Patienten mit Arthrose der Hand, eine weitere Studie untersuchte die Auswirkung der Therapie bei Arthrose der Hüfte. 2 Studien untersuchten den Effekt der Moorbäder bei Patienten mit chronischen Rückenschmerzen. Insgesamt zeigten sich signifikante Verbesserungen der Funktion, Lebensqualität und Schmerzlinderung bei den Patienten unter Heiltorftherapie.

骨关节炎在药物支出、住院率、工作效率和暂时或永久丧失工作能力方面具有巨大的社会经济影响。泥浆疗法被认为是骨关节炎的一种潜在的保守治疗选择。然而,几项试验的结果仍然存在争议。方法系统回顾泥疗法治疗骨关节炎的文献,探讨泥疗法治疗骨关节炎的有效性。结果纳入的19项研究中,有15项研究考察了泥浴疗法治疗膝关节骨关节炎的效果。最后,我们系统地回顾了文献资料,并在主要结果的基础上对结果进行了总结。结果显示骨关节炎患者在功能、生活质量和感知疼痛方面有显著改善。结论:随机对照试验结果表明,泥浆疗法与药物治疗或物理治疗等其他治疗形式相结合,是一种有前景的综合和协同多学科方法的一部分。据报道,令人印象深刻的药物减少了常规治疗剂量,可能导致更低的成本和药物相关的不良事件。
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引用次数: 0
The Role of Objective Movement Analysis in the Control of Yoga Asanas: A Case Study. 客观动作分析在瑜伽体式控制中的作用。案例研究。
IF 1.8 4区 医学 Q2 Medicine Pub Date : 2024-01-01 Epub Date: 2024-02-08 DOI: 10.1159/000535312
Magdalena Fronczek, Karolina Kopacz, Łukasz Kopacz, Gianluca Padula

Introduction: Yoga is classified as a form of complementary and alternative medicine. It can be used in many disciplines including physiotherapy, medicine, and sport. The objective of the study was to identify possible biomechanical problems during yoga practice and to minimize the risk of injury.

Case presentation: Objective evaluation of the symmetry of asanas, balance, stability, and muscle tension was provided in case of a 37-year-old woman, practicing mainly aerial and Hatha yoga for 6 years. The bigger body tilt and deviations in center of pressure (COP) parameters were observed in tadasana during forward examinations. In tadasana, the highest muscle activity was observed in the rectus femoris. In case of forward tadasana observation, the highest activity was found in the gastrocnemius and in the lumbar portion of the erector spinae. During backward tadasana trial, the most active were the tibialis anterior and rectus femoris muscles. In garudasana and natarajasana, the symmetry of the trunk position in relation to the lower limbs was observed, regardless of the supporting limb. In the same way, COP parameters in garudasana were similar regardless of the supporting limb. However, in natarajasana, the higher COP displacement parameters were observed in the case of the nondominant supporting limb. As for the electromyographic evaluation of garudasana and natarajasana, the highest muscle activity was observed in the lumbar portion of the erector spinae. In chakrasana, a slightly greater angle of the hip extension was observed in the left hip. A higher muscle activity in chakrasana was observed in the lumbar portion of the right erector spinae. In sirsasana, no significant displacements of the cervical spine were observed, but a higher activity of the left sternocleidomastoid muscle was found.

Conclusion: With the use of objective movement analysis, possible biomechanical problems were identified. Attention should be paid to the normalization of the tension in the lumbar part of the right erector spinae and the right sternocleidomastoid muscle, as well as to the balance training in positions on the nondominant lower limb. Objective movement analysis can be a useful tool for instructors or physiotherapists to adjust yoga programs and correct asanas in order to avoid future injuries.

EinleitungYoga gilt als Form der Komplementär- und Alternativmedizin. Es ist in vielen Disziplinen einsetzbar, von Physiotherapie über Medizin bis Sport. Das Ziel dieser Studie war es, mögliche biomechanische Probleme bei der Ausübung von Yoga zu identifizieren, um das Verletzungsrisiko zu minimieren.Vorstellung des FallsEine objektive Beurteilung der Symmetrie der Asanas, des Gleichgewichts, der Stabilität und der Muskelspannung erfolgte bei einer 37-jährigen Frau, die seit 6 Jahren hauptsächlich Aerial- und Hatha-Yoga praktiziert. Stärkere Körperneigung und Abwe

简介瑜伽被归类为一种补充和替代医学。它可用于许多学科,包括物理治疗、医学和体育。本研究的目的是找出瑜伽练习过程中可能存在的生物力学问题,以尽量减少受伤的风险:对一名 37 岁女性的体式对称性、平衡性、稳定性和肌肉张力进行了客观评估,该女性主要练习空中瑜伽和哈他瑜伽已有 6 年之久。在前方检查时,观察到身体倾斜度和压力中心参数的偏差在塔达萨纳式中较大。在蝌蚪式中,股直肌的肌肉活动量最大。在向前式的观察中,腓肠肌和竖脊肌腰部的肌肉活动量最大。在后仰式试验中,最活跃的是胫骨前肌和股直肌。在加鲁达式和纳塔拉加式中,无论支撑肢体是什么,躯干与下肢的位置都是对称的。同样,无论支撑肢是什么,伽鲁达萨纳式中的压力中心参数也相似。然而,在纳塔拉伽马式中,非优势支撑肢的COP位移参数较高。至于伽鲁达式和纳塔拉贾萨式的肌电图评估,在竖脊肌的腰部观察到了最高的肌肉活动。在查克拉萨纳式中,左侧髋关节的伸展角度略大。在脉动式中,右竖脊肌腰部的肌肉活动较高。在Sirsasana式中,没有观察到颈椎有明显的位移,但发现左侧胸锁乳突肌的活动度较高:结论:通过客观的动作分析,发现了可能存在的生物力学问题。结论:通过客观运动分析,发现了可能存在的生物力学问题,应注意使右侧竖脊肌腰部和右侧胸锁乳突肌的张力恢复正常,并进行非优势下肢体位的平衡训练。客观的动作分析可以成为教练或理疗师调整瑜伽课程和纠正体式的有用工具,以避免将来受伤。
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引用次数: 0
Efficacy of Acupuncture Combined with Traditional Chinese Medicine Fumigation Therapy in Sequelae of Pelvic Inflammatory Disease: A Systematic Review and Meta-Analysis. 针灸结合中药熏蒸疗法对盆腔炎后遗症的疗效:系统回顾与元分析》。
IF 1.8 4区 医学 Q2 Medicine Pub Date : 2024-01-01 Epub Date: 2024-02-08 DOI: 10.1159/000536101
Li Yang, Yajun Li, Shuang Zhang, Haiqing Qian, Wenting Xu, Jinfen Yu

Background and objective: Acupuncture combined with traditional Chinese medicine fumigation is increasingly being used in treating sequelae of pelvic inflammatory disease (SPID). However, there is a lack of meta-analysis on the effectiveness of acupuncture combined with traditional Chinese medicine fumigation in treating SPID. The aim of this study was to assess the feasibility of combining acupuncture with traditional Chinese medicine fumigation in the treatment of SPID.

Methods: We searched eight databases for studies on acupuncture combined with traditional Chinese medicine fumigation for the treatment of SPID from the date of establishment to October 29, 2022. We assessed the quality of included studies by using the Cochrane bias risk tool. Pooled results were expressed as risk ratios (RRs), with a 95% confidence interval (CI). In addition, we identified sources of heterogeneity by sensitivity analysis, assessed publication bias by Egger's test, and assessed the quality of the evidence by Grades of Recommendation, Assessment, Development, and Evaluation (GRADE). All statistical analyses were performed by Review Manager 5.3 and Stata 14.

Results: Finally, seven studies with a total of 663 participants were included. We found a significant difference in the total effective rate in the acupuncture combined with the fumigation group compared with the acupuncture group in the treatment of SPID (RR = 1.17, 95% CI [1.09, 1.25], p = 0.0001 < 0.05; I2 = 0%; 6 trials), and a significant difference in the total effective rate in the acupuncture combined with fumigation group compared with the fumigation group in the treatment of SPID (RR = 1.42, 95% CI [1.21, 1.66], p = 0.0001 < 0.05; 5 trials).

Conclusion: The clinical efficacy of acupuncture combined with herbal fumigation in the treatment of SPID is relatively good. Larger scale studies are needed in the future.

Hintergrund und ZielAkupunktur in Kombination mit Fumigation, einem Verfahren der Traditionellen Chinesischen Medizin, wird zunehmend in der Behandlung von Folgeerscheinungen von Beckenentzündungen (SPID; sequelae of pelvic inflammatory disease) eingesetzt. Es mangelt jedoch an Metaanalysen zur Wirksamkeit der Akupunktur in Kombination mit Fumigation gemäß der Traditionellen Chinesischen Medizin in der Behandlung von SPID. Das Ziel dieser Studie ist die Beurteilung der Machbarkeit der Kombination aus Akupunktur und Fumigation gemäß der Traditionellen Chinesischen Medizin in der Behandlung von SPID.MethodenWir durchsuchten acht Datenbanken nach Studien zur Akupunktur in Kombination mit Fumigation gemäß der Traditionellen Chinesischen Medizin in der Behandlung von Folgeerscheinungen von SPID von der Einrichtung bis zum 29. Oktober 2022. Wir beurteilten die Qualität der eingeschlossenen Studien mit dem Cochrane-Tool zur Bewertung des Bias-Risikos.

背景和目的:针灸结合中药熏蒸治疗盆腔炎(SPID)后遗症的应用越来越广泛。然而,关于针灸结合中药熏蒸治疗 SPID 的有效性,目前还缺乏荟萃分析。本研究旨在评估针灸结合中药熏蒸治疗 SPID 的可行性:方法:我们检索了 8 个数据库中有关针灸结合中药熏蒸治疗盆腔炎后遗症的研究,时间从数据库建立之日起至 2022 年 10 月 29 日。我们使用 Cochrane 偏倚风险工具评估了纳入研究的质量。汇总结果以风险比(RR)和 95% 置信区间(CI)表示。此外,我们还通过敏感性分析确定了异质性的来源,通过 Egger 检验评估了发表偏倚,并通过推荐、评估、发展和评价等级(GRADE)评估了证据质量。所有统计分析均由 Review Manager 5.3 和 Stata 14.Results 进行:最后,共纳入了 7 项研究,共计 663 名参与者。我们发现,在治疗 SPID 时,针灸联合熏蒸组与针灸组的总有效率有明显差异(RR = 1.17,95% CI [1.09,1.25],P = 0.0001 < 0.05;I2 = 0%;6项试验),针灸联合熏蒸组与熏蒸组治疗SPID的总有效率相比差异显著(RR = 1.42,95% CI [1.21,1.66],P = 0.0001 < 0.05;5项试验):结论:针灸联合中药熏蒸治疗 SPID 的临床疗效相对较好。结论:针灸联合中药熏蒸治疗SPID的临床疗效相对较好,今后需要进行更大规模的研究。
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引用次数: 0
Indication-Specific Effect of a Phytotherapeutic Remedy on Human Fetal Osteoblastic Cells: An in vitro Analysis. 植物疗法对人类胎儿成骨细胞的特异性影响:体外分析
IF 1.8 4区 医学 Q2 Medicine Pub Date : 2024-01-01 Epub Date: 2024-02-22 DOI: 10.1159/000535845
Victoria Franziska Struckmann, Stephanie Allouch-Fey, Ulrich Kneser, Leila Harhaus, Matthias Schulte

Background: Impaired fracture healing is a recurring interdisciplinary medical challenge. Alternative treatment concepts, apart from conventional medicine, are popular, but scientific evidence on their effects is still lacking. Plant-derived substances are widely assumed to support bone homeostasis. To clarify the effects on bone healing mechanisms, a commercially available, homeopathic-spagyric remedy, containing inter alia two herbal substances with assumed osteogenic potential, equisetum arvense and bellis perennis, was analyzed.

Methods: Human fetal osteoblastic (hFOB) 1.19 cells were incubated with the test substance in serial dilutions from 10 to 0.00001%. Cell viability has been evaluated through ATP level (CTG assay) and MTT tetrazolium reduction. Cell proliferation was analyzed by BrdU incorporation and cell migration by wound healing assay (WHA) via image analysis. Additionally, determination of the expression of key genes via real-time PCR and proteins via proteome array for inflammation, cell proliferation, and angiogenesis were performed.

Results: An incubation of hFOB 1.19 cells with the test substance for 24/72 h showed no reduction in cell number, viability, or proliferation. Cell migration was unimpaired. The test substance induced inflammatory genes and growth factors along with genes of osseous regeneration (ALP, Col1, IL-1α, IL-6, IL-8, IL-10, Osteocalcin, Osteonectin, RUMX2, TGF, VEGFA). Increased protein expression was found in multiple cytokines, chemokines, and acute phase proteins.

Conclusion: The test substance did not impair cell vitality parameters (MTT, CTG, BrdU, and WHA). A tendency to activate growth factors, bone regeneration genes, and proteins was shown for osteoblasts, indicating a possible positive effect on osteogenic processes.

HintergrundStörungen des komplexen Prozesses der Knochenheilung stellen auch heutzutage noch eine interdisziplinäre Herausforderung dar. Es existieren zahlreiche alternative Therapiekonzepte, deren Evidenz jedoch häufig nicht belegt ist. Es wird davon ausgegangen, dass pflanzliche Substanzen die Knochenheilung unterstützen können. Wir analysierten die Wirkung eines kommerziellen, homeopathisch-spagyrischen Heilmittels, welches unter anderen zwei Pflanzenstoffe enthält, denen ein osteogenes Potential zugeschrieben wird (Equisetum arvense und Bellis perennis).MethodenEs erfolgte eine Inkubation humaner fetaler Osteoblastenzellen (hFOB 1.19) mit der Testsubstanz in absteigender Verdünnung von 10 bis 0.00001%. Die Zellvitalität wurde anhand der Zellzahlbestimmung durch ATP-abhängige metabolische Aktivität mittels CellTiter-Glo® (CTG) Test sowie durch Tetrazolium Reduktion (MTT) evaluiert. Die Zellproliferation wurde durch Inkorporation von Bromdesoxyuridin (BrdU) in die DNA aktiver Zellen analysiert. Der Wound Healing Assay (WHA)

背景 骨折愈合障碍是一个反复出现的跨学科医学难题。除传统医学外,替代治疗概念也很流行,但有关其效果的科学证据仍然缺乏。人们普遍认为植物提取物可支持骨平衡。为了阐明对骨愈合机制的影响,我们分析了一种市售的顺势疗法-槐树疗法,其中含有两种被认为具有成骨潜能的草药物质:马钱子和贝母。方法 将人胎儿成骨细胞(hFOB1.19)与测试物质一起孵育,稀释度从 10%到 0,00001% 不等。通过 ATP 水平(CTG 检测法)和 MTT 四氮唑还原法评估细胞活力。细胞增殖通过 BrdU 结合进行分析,细胞迁移通过伤口愈合试验(WHA)进行图像分析。此外,还通过实时 PCR 测定了关键基因的表达,并通过蛋白质组阵列测定了炎症、细胞增殖和血管生成方面的蛋白质。结果 hFOB 1.19 与试验物质孵育 24/72 小时后,细胞数量、活力和增殖均未减少。细胞迁移不受影响。试验物质可诱导炎症基因和生长因子以及骨再生基因。(ALP、Col1、IL-1α、IL-6、IL-8、IL-10、骨钙素、骨连蛋白、RUMX2、TGF、VEGFA)。发现多种细胞因子、趋化因子和急性期蛋白的蛋白表达量增加。结论 试验物质不会损害细胞活力参数(MTT、CTG、BrdU 和 WHA)。成骨细胞的生长因子、骨再生基因和蛋白质有被激活的趋势,这表明它可能对成骨过程产生积极影响。
{"title":"Indication-Specific Effect of a Phytotherapeutic Remedy on Human Fetal Osteoblastic Cells: An in vitro Analysis.","authors":"Victoria Franziska Struckmann, Stephanie Allouch-Fey, Ulrich Kneser, Leila Harhaus, Matthias Schulte","doi":"10.1159/000535845","DOIUrl":"10.1159/000535845","url":null,"abstract":"<p><strong>Background: </strong>Impaired fracture healing is a recurring interdisciplinary medical challenge. Alternative treatment concepts, apart from conventional medicine, are popular, but scientific evidence on their effects is still lacking. Plant-derived substances are widely assumed to support bone homeostasis. To clarify the effects on bone healing mechanisms, a commercially available, homeopathic-spagyric remedy, containing inter alia two herbal substances with assumed osteogenic potential, equisetum arvense and bellis perennis, was analyzed.</p><p><strong>Methods: </strong>Human fetal osteoblastic (hFOB) 1.19 cells were incubated with the test substance in serial dilutions from 10 to 0.00001%. Cell viability has been evaluated through ATP level (CTG assay) and MTT tetrazolium reduction. Cell proliferation was analyzed by BrdU incorporation and cell migration by wound healing assay (WHA) via image analysis. Additionally, determination of the expression of key genes via real-time PCR and proteins via proteome array for inflammation, cell proliferation, and angiogenesis were performed.</p><p><strong>Results: </strong>An incubation of hFOB 1.19 cells with the test substance for 24/72 h showed no reduction in cell number, viability, or proliferation. Cell migration was unimpaired. The test substance induced inflammatory genes and growth factors along with genes of osseous regeneration (ALP, Col1, IL-1α, IL-6, IL-8, IL-10, Osteocalcin, Osteonectin, RUMX2, TGF, VEGFA). Increased protein expression was found in multiple cytokines, chemokines, and acute phase proteins.</p><p><strong>Conclusion: </strong>The test substance did not impair cell vitality parameters (MTT, CTG, BrdU, and WHA). A tendency to activate growth factors, bone regeneration genes, and proteins was shown for osteoblasts, indicating a possible positive effect on osteogenic processes.</p><p><p><title>Hintergrund</title>Störungen des komplexen Prozesses der Knochenheilung stellen auch heutzutage noch eine interdisziplinäre Herausforderung dar. Es existieren zahlreiche alternative Therapiekonzepte, deren Evidenz jedoch häufig nicht belegt ist. Es wird davon ausgegangen, dass pflanzliche Substanzen die Knochenheilung unterstützen können. Wir analysierten die Wirkung eines kommerziellen, homeopathisch-spagyrischen Heilmittels, welches unter anderen zwei Pflanzenstoffe enthält, denen ein osteogenes Potential zugeschrieben wird (<italic>Equisetum arvense</italic> und <italic>Bellis perennis</italic>).<title>Methoden</title>Es erfolgte eine Inkubation humaner fetaler Osteoblastenzellen (hFOB 1.19) mit der Testsubstanz in absteigender Verdünnung von 10 bis 0.00001%. Die Zellvitalität wurde anhand der Zellzahlbestimmung durch ATP-abhängige metabolische Aktivität mittels CellTiter-Glo® (CTG) Test sowie durch Tetrazolium Reduktion (MTT) evaluiert. Die Zellproliferation wurde durch Inkorporation von Bromdesoxyuridin (BrdU) in die DNA aktiver Zellen analysiert. Der Wound Healing Assay (WHA)","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139930381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of Quality of Reporting in Randomized Controlled Trials of Moxibustion for Chronic Diseases Using the Consolidated Standards of Reporting Trials and Standards for Reporting Interventions in Clinical Trials of Moxibustion Statements. 使用 CONSORT 和 STRICTOM 声明评估艾灸治疗慢性病随机对照试验的报告质量。
IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-01-01 Epub Date: 2024-08-08 DOI: 10.1159/000540641
Jianrong Chen, Guihua Deng, Huilin Liu, Qiuyun Xue, Yaojun Cai, Jiao Wang, Sheng Xu, Xu Zhou, Jiancheng Wang

Introduction: Moxibustion is clinically used for treating various chronic diseases; however, the reporting quality of current published RCTs of moxibustion is unclear. The objective of this study was to assess the reporting quality of RCTs focusing on moxibustion as a treatment for chronic diseases.

Methods: Seven databases were searched to identify relevant RCTs. Criteria for evaluating the reporting quality of standard RCT elements and moxibustion intervention-related information were developed based on the CONSORT statement and its STRICTOM extension, respectively. Multivariate regression models were used to investigate factors impacting reporting quality.

Results: A total of 310 RCTs were included, with 41 (7.6%) published in English journals and 269 (92.4%) in Chinese journals. The median CONSORT and STRICTOM scores of these RCTs, with a maximum score of 100, were 41.2 and 62.9, respectively. RCTs with a later publication year and protocol registration or ethical approval exhibited significantly higher CONSORT and STRICTOM scores. Higher CONSORT scores were also significantly associated with English language publication, funding support, and inclusion of a safety evaluation, while higher STRICTOM scores were additionally associated with an active control design.

Conclusion: The reporting quality of RCTs focusing on moxibustion treatment for chronic diseases is subpar, with gradual but limited improvement over the last 25 years. To enhance the reporting quality of moxibustion RCTs, researchers should develop a comprehensive study protocol and standardize result reporting based on CONSORT and STRICTOM statements. Registration platforms, ethical approval organizations, funders, and journals can also contribute to this improvement by bolstering structured information reporting in the review process.

背景:艾灸在临床上被用于治疗各种慢性疾病;然而,目前已发表的有关艾灸的RCT报告质量并不明确:目的:评估以艾灸治疗慢性病为重点的研究性临床试验的报告质量:方法:检索七个数据库以确定相关的 RCT。根据 CONSORT 声明及其 STRICTOM 扩展,分别制定了标准 RCT 要素和艾灸干预相关信息的报告质量评估标准。采用多变量回归模型研究影响报告质量的因素:共纳入 310 项 RCT,其中 41 项(7.6%)发表于英文期刊,269 项(92.4%)发表于中文期刊。这些 RCT 的 CONSORT 和 STRICTOM 评分中位数(最高分 100 分)分别为 41.2 分和 62.9 分。发表年份较晚、进行了方案注册或伦理批准的 RCT 的 CONSORT 和 STRICTOM 得分明显更高。较高的CONSORT得分还与英文发表、资金支持和包含安全性评价有明显关系,而较高的STRICTOM得分还与主动对照设计有关:结论:以艾灸治疗慢性病为重点的研究性临床试验的报告质量不高,在过去的 25 年中逐步改善,但改善有限。为提高艾灸 RCT 的报告质量,研究人员应制定全面的研究方案,并根据 CONSORT 和 STRICTOM 声明规范结果报告。注册平台、伦理审批机构、资助者和期刊也可以通过在审稿过程中加强结构化信息报告来促进这一改进。
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引用次数: 0
The Earth as a Living Organism: Contribution of Integrative Medicine to the Healing of Our Planet (One Health). The Earth as a Living Organism - Contribution of Integrative Medicine to the healing of our planet (One Health) Die Erde als lebendiger Organismus - Beiträge einer Integrativen Medizin zur Gesundung unseres Planeten (One Health)。
IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-01-01 Epub Date: 2024-07-26 DOI: 10.1159/000540226
Harald Matthes, Erik W Baars, Benno Brinkhaus, Moritz Christoph, Friedrich Edelhäuser, Christian Grah, Carsten Gründemann, Christian Keßler, David Martin, Andreas Michalsen, Bernd Rosslenbroich, Jana Siroka, Georg Soldner, Michael Teut, Jan Vagedes, Stefan N Willich

Background: Considering the analogies between the disruption in ecological systems and in individuals, the concept of integrative medicine is extended to the One Health concept and integrative medicine is introduced as an innovative model for guidance/correction in patients' therapy as well as in ecological realignment.

Summary: The specific elements of integrative medicine that can be applied to human health as well as to environmental health are described (e.g. self-regulation, salutogenic healing processes, transdisciplinary multimodal approaches, methodological pluralism). The need for sustainable use of limited resources in medicine and pharmacy is pointed out. As examples for urgent action, the need of taking into account the whole life cycle of pharmaceutical products as well as the impact of diet for human and planetary health are mentioned.

Key message: Self-regulation plays a crucial role in human and environmental health; sustainable promotion of self-regulation enables people to become co-creators of their own health. Such a fundamental change requires transformation of one's inner relationship to nature and to oneself. The aim of the mini-review was to concretize individual fields of action and to investigate the question of whether the concepts of integrative medicine can be transferred from humans to the environment and thus to planetary health and whether this makes sense.

背景:考虑到生态系统的破坏与个人的破坏之间的相似性,综合医学的概念被扩展到 "一体健康 "的概念,并将综合医学作为一种创新模式引入到患者治疗和生态调整的控制/纠正中。摘要:描述了可应用于人类健康和环境健康的综合医学的具体要素(如自我调节、致敏治疗过程、跨学科多模式方法、方法论多元化)。指出了在医学和药学领域可持续利用有限资源的必要性。关键信息:自我调节在人类和环境健康中发挥着至关重要的作用,可持续地促进自我调节能使人们成为自身健康的共同创造者。这种根本性的改变要求人们转变与自然和自身的内在关系。摘要 背景:根据生态系统紊乱与人类健康之间的类比关系,将 "整合医学 "的概念延伸到 "一体健康 "的概念中,并提出 "整合医学 "是控制/纠正患者治疗和调整生态方向的创新模式。摘要:介绍了可应用于人类健康和环境健康的中西医结合医学的具体要素(包括自我调节、治疗过程、跨学科多模式方法、方法论多元化)。强调了在医学和药学领域可持续利用有限资源的必要性。作为迫切需要采取行动的例子,强调了考虑医药产品整个生命周期的必要性,以及调整营养的重要性,这不仅是为了人类健康,也是为了地球健康。关键信息:自我调节在人类和环境健康方面发挥着至关重要的作用。可持续地促进自我调节能使人们成为自身健康的共同创造者。这种根本性的改变要求人们转变与自然和自身的内在关系。
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引用次数: 0
Evaluation of the Effectiveness of Wet Cupping Therapy in Fibromyalgia Patients: A Randomized Controlled Trial. 湿罐治疗纤维肌痛患者的疗效评价:一项随机对照试验。
IF 1.8 4区 医学 Q2 Medicine Pub Date : 2024-01-01 Epub Date: 2023-10-24 DOI: 10.1159/000534637
Canan Karacaoglu, Suleyman Ersoy, Emin Pala, Velittin Selcuk Engin

Introduction: The aim of this study was to investigate the efficacy of wet cupping therapy (WCT) in patients diagnosed with fibromyalgia syndrome (FMS) as a complementary method in fibromyalgia treatment.

Materials and methods: A total of 120 participants between 18 and 65 years who were diagnosed with FMS were included in the study. They were randomized into two groups: 60 patients as the intervention and 60 patients as the control group. Each participant in the intervention group received 3 sessions of WCT once a month in addition to their ongoing treatment whereas the control group received only routine medical treatment. The evaluation was conducted in both groups based on the fibromyalgia impact questionnaire (FIQ), visual analog scale (VAS), and quality of life scale (QoL) parameters initially (at 0th week) and 1 week after the WCT sessions (at the 10th week). For the comparison of quantitative variables showing a normal distribution between the two groups, the Student's t test was used, while the Mann-Whitney U test was employed for variables not showing a normal distribution. The χ2 test and Continuity (Yates) Correction were used for the comparison of qualitative data. The significance level was set at p < 0.05.

Results: The study included 107 female and 13 male participants, with a mean age of 45.79 ± 8.49 years. When comparing the pretreatment FIQ, VAS, and QoL scores with the scores obtained after three sessions of WCT, it was observed that in the WCT group, the FIQ and VAS values significantly decreased compared to the control group while the QoL significantly increased compared to the control group (p < 0.001 in all).

Conclusion: The findings obtained from this study indicate that WCT can be an effective treatment option for patients with FMS.

EinleitungMit dieser Studie soll die Wirksamkeit der blutigen Schröpftherapie (wet cupping therapy, WCT) bei Patienten mit diagnostiziertem Fibromyalgie-Syndrom (FMS) als komplementäre Methode in der Fibromyalgie-Behandlung untersucht werden.Material und MethodenInsgesamt wurden 120 Teilnehmer mit diagnostiziertem FMS zwischen 18 und 65 Jahren in die Studie aufgenommen. Diese wurden randomisiert zwei Gruppen zugeordnet: 60 Patienten wurden der Interventionsgruppe zugewiesen und 60 Patienten der Kontrollgruppe. Alle Teilnehmer der Interventionsgruppe erhielten einmal im Monat drei Sitzungen WCT zusätzlich zu ihrer laufenden Therapie, während die Kontrollgruppe lediglich die Standardbehandlung erhielt. Die Bewertung erfolgte in beiden Gruppen anhand des Fibromyalgia Impact Questionnaire (FIQ), der Visuellen Analogskala (VAS) und der Parameter der Quality of Life (QoL) Scale zu Beginn (in Woche 0) und eine Woche nach den WCT-Sitzungen (in Woche 10). Für den Vergleich von quantitativen Variablen, die eine Normalverteilung zwischen den beiden Gruppen aufwiesen, wurde

目的:本研究的目的是探讨湿拔罐疗法(WCT)作为纤维肌痛治疗的补充方法对诊断为纤维肌痛综合征(FMS)的患者的疗效。材料和方法:共有120名18-65岁的参与者被诊断为FMS。他们被随机分为两组:60名患者作为干预组,60名患者为对照组。干预组的每个参与者除了正在进行的治疗外,每月还接受3次WCT治疗,而对照组只接受常规药物治疗。根据纤维肌痛影响问卷(FIQ)、视觉模拟量表(VAS)和生活质量量表(QoL)参数在两组中进行评估,最初(第0周)和WCT治疗后1周(第10周)。为了比较两组之间显示正态分布的定量变量,使用了Student t检验,而Mann-Whitney U检验用于未显示正态分配的变量。卡方检验和连续性(Yates)校正用于定性数据的比较。显著性水平设定为p。结果:该研究包括107名女性和13名男性参与者,平均年龄为45.79±8.49岁。当将治疗前的FIQ、VAS和生活质量评分与WCT三个疗程后获得的评分进行比较时,观察到在WCT组中,FIQ和VAS值与对照组相比显著降低,而QoL与对照组比较显著增加(结论:本研究结果表明,WCT可以作为FMS患者的有效治疗选择。试验注册:Clinicaltrials.gov注册ID:NCT05253482日期:2022年9月2日关键词:补充医学、纤维肌痛、湿杯疗法、Hijama。
{"title":"Evaluation of the Effectiveness of Wet Cupping Therapy in Fibromyalgia Patients: A Randomized Controlled Trial.","authors":"Canan Karacaoglu, Suleyman Ersoy, Emin Pala, Velittin Selcuk Engin","doi":"10.1159/000534637","DOIUrl":"10.1159/000534637","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to investigate the efficacy of wet cupping therapy (WCT) in patients diagnosed with fibromyalgia syndrome (FMS) as a complementary method in fibromyalgia treatment.</p><p><strong>Materials and methods: </strong>A total of 120 participants between 18 and 65 years who were diagnosed with FMS were included in the study. They were randomized into two groups: 60 patients as the intervention and 60 patients as the control group. Each participant in the intervention group received 3 sessions of WCT once a month in addition to their ongoing treatment whereas the control group received only routine medical treatment. The evaluation was conducted in both groups based on the fibromyalgia impact questionnaire (FIQ), visual analog scale (VAS), and quality of life scale (QoL) parameters initially (at 0th week) and 1 week after the WCT sessions (at the 10th week). For the comparison of quantitative variables showing a normal distribution between the two groups, the Student's t test was used, while the Mann-Whitney U test was employed for variables not showing a normal distribution. The χ2 test and Continuity (Yates) Correction were used for the comparison of qualitative data. The significance level was set at p &lt; 0.05.</p><p><strong>Results: </strong>The study included 107 female and 13 male participants, with a mean age of 45.79 ± 8.49 years. When comparing the pretreatment FIQ, VAS, and QoL scores with the scores obtained after three sessions of WCT, it was observed that in the WCT group, the FIQ and VAS values significantly decreased compared to the control group while the QoL significantly increased compared to the control group (p &lt; 0.001 in all).</p><p><strong>Conclusion: </strong>The findings obtained from this study indicate that WCT can be an effective treatment option for patients with FMS.</p><p><p><title>Einleitung</title>Mit dieser Studie soll die Wirksamkeit der blutigen Schröpftherapie (wet cupping therapy, WCT) bei Patienten mit diagnostiziertem Fibromyalgie-Syndrom (FMS) als komplementäre Methode in der Fibromyalgie-Behandlung untersucht werden.<title>Material und Methoden</title>Insgesamt wurden 120 Teilnehmer mit diagnostiziertem FMS zwischen 18 und 65 Jahren in die Studie aufgenommen. Diese wurden randomisiert zwei Gruppen zugeordnet: 60 Patienten wurden der Interventionsgruppe zugewiesen und 60 Patienten der Kontrollgruppe. Alle Teilnehmer der Interventionsgruppe erhielten einmal im Monat drei Sitzungen WCT zusätzlich zu ihrer laufenden Therapie, während die Kontrollgruppe lediglich die Standardbehandlung erhielt. Die Bewertung erfolgte in beiden Gruppen anhand des Fibromyalgia Impact Questionnaire (FIQ), der Visuellen Analogskala (VAS) und der Parameter der Quality of Life (QoL) Scale zu Beginn (in Woche 0) und eine Woche nach den WCT-Sitzungen (in Woche 10). Für den Vergleich von quantitativen Variablen, die eine Normalverteilung zwischen den beiden Gruppen aufwiesen, wurde","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50157243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Complementary Medicine Research
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