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Effect of Tuina Combined with Chinese Herbal Compress on Primary Dysmenorrhea with Cold Coagulation and Blood Stasis Syndrome: A Study Protocol for a Randomized Controlled Trial. 推拿配合中药敷贴治疗寒凝血瘀型原发性痛经的随机对照研究方案
IF 1.8 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-01-01 Epub Date: 2023-11-27 DOI: 10.1159/000534335
Paphawarin Asawadethmetakul, Fangfang Xie, Chaoqun Xie, Jianwen Ma, Yanli You, Fei Yao
<p><strong>Indroduction: </strong>Primary dysmenorrhea (PD) is a very common issue in young women that reduces the quality of women's lives. Both Western medicine and traditional Chinese medicine (TCM) provide several ways to treat PD; however, TCM treatment exhibits fewer side effects for the patient. Tuina massage and Chinese herbal compresses are considered forms of external TCM therapy that have been widely used to treat PD, especially in China. Therefore, to provide the most effective and safe treatment for PD, we combined Tuina and Chinese herbal compresses together in this observational study.</p><p><strong>Methods: </strong>A randomized controlled trial (RCT) consisting of 114 participants from the Shanghai University of Traditional Chinese Medicine who meet inclusion criteria will be divided into two groups in a 1:1 allocation ratio. The intervention group will receive Tuina combined with Chinese herbal compress therapy, while the control group will only receive Chinese herbal compress therapy. The treatment will be given 3 days before menstruation (once per day, 3 times per menstrual cycle). The primary outcome will be measured with the Visual Analog Scale (VAS). The secondary outcomes will be measured by the Dysmenorrhea Symptom Score, the Chinese Medical Dysmenorrhea Symptom Score, the Self-Rating Anxiety Scale (SAS), the Self-Rating Depression Scale (SDS), and the pain threshold at Guanyuan (CV4).</p><p><strong>Conclusion: </strong>This study will be the first RCT that will entail the combination of Tuina and Chinese herbal compresses to treat PD in the category of cold coagulation and blood stasis syndrome. If the results demonstrate that Tuina combined with a Chinese herbal compress is effective, we posit that this study will provide evidence-based references for a potential alternative treatment to treat PD in the future.</p><p><p><title>Einleitung</title>Die primäre Dysmenorrhoe (PD) ist ein Problem, das bei jungen Frauen sehr häufig auftritt und ihre Lebensqualität beeinträchtigt. Sowohl die westliche Medizin als auch die traditionelle chinesische Medizin (TCM) bieten verschiedene Therapiemöglichkeiten zur Behandlung der PD, allerdings ist die TCM mit weniger Nebenwirkungen für die Patientin verbunden. Tuina-Massage und chinesische Kräuterkompressen gelten als Formen der äußerlichen TCM-Therapie, die besonders in China zur Behandlung der PD weit verbreitet sind. Daher haben wir in dieser Beobachtungsstudie Tuina und chinesische Kräuterkompressen kombiniert, um eine möglichst wirksame und sichere Behandlung der PD bereitzustellen.<title>Methoden</title>Es handelt sich um eine randomisierte kontrollierte Studie (randomized controlled trial, RCT), bei der 114 Teilnehmerinnen der Shanghai University of Traditional Chinese Medicine, die die Einschlusskriterien erfüllen, im Verhältnis 1:1 in zwei Gruppen aufgeteilt werden. Die Interventionsgruppe erhält Tuina in Kombination mit chinesischen Kräuterkompressen, während die Kontrollgrupp
原发性痛经(PD)是年轻女性中非常常见的问题,降低了女性的生活质量。西医和中医都提供了几种治疗帕金森病的方法;然而,中医治疗对患者的副作用更少。推拿按摩和中药敷贴被认为是治疗帕金森病的中医外治形式,尤其在中国被广泛使用。因此,为了给PD提供最有效、最安全的治疗方法,我们在本观察性研究中将推拿与中药敷药相结合。方法:随机对照试验(RCT)选取114名来自上海中医药大学符合纳入标准的受试者,按1:1的比例分为两组。干预组采用推拿结合中药热敷疗法,对照组仅采用中药热敷疗法。治疗在月经前3天开始(每天1次,每个月经周期3次)。主要结果将用视觉模拟量表(VAS)测量。次要结局采用痛经症状评分、中医痛经症状评分、焦虑自评量表(SAS)、抑郁自评量表(SDS)和痛经阈值(CV4)进行测量。结论:本研究将是首个采用推拿结合中药敷贴治疗寒凝血瘀型帕金森病的RCT研究。如果结果表明推拿联合中药敷贴是有效的,我们认为本研究将为未来治疗PD的潜在替代疗法提供循证参考。EinleitungDie primäre痛经(PD) ist in Problem, das bei jungen Frauen sehr häufig auftritt und ire Lebensqualität beeinträchtigt。Sowohl die westliche Medizin也auch die traditionelle chinese Medizin (TCM) bieten verschiedene Therapiemöglichkeiten zur Behandlung der PD, allerdings ist die TCM mit weniger Nebenwirkungen fre die Patientin verbunden。推拿推拿与中医Kräuterkompressen gelten als Formen der äußerlichen中医治疗,中国中医治疗专家,中国中医治疗专家。她在北京的研究中心研究了中国和中国的关系Kräuterkompressen kombiniert,以及möglichst workksame and where Behandlung der PD bereitzustellen。方法:采用随机对照试验(RCT),在上海中医药大学进行随机对照试验,在上海中医药大学进行随机对照试验,在上海中医药大学进行随机对照试验,在上海中医药大学进行随机对照试验,在上海中医药大学进行随机对照试验,在上海中医药大学进行随机对照试验,在上海中医药大学进行随机对照试验。模具干预组erhält中医联合推拿组Kräuterkompressen, während模具控制组,中医联合推拿组Kräuterkompressen erhält。Die Behandlung erfolt drei age vor der menstrual(末梢täglich,月经前梦)。Das primäre Zielkriterium wind and hand der visuellen Analogskala (VAS) gemessen。Die sekundären zielkriteren werden mithilfe des痛经症状-评分,des中医痛经症状-评分,der焦虑自评量表(SAS), der抑郁自评量表(SDS)和der Schmerzschwelle am ganyan - akupunkturpunkt (CV4)。临床研究:随机对照研究:中医与中医联合研究:黄萎病与黄萎病联合研究:黄萎病与黄萎病联合研究:黄萎病与黄萎病联合研究:黄萎病分类:Kältekoagulation[1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1] [1]
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引用次数: 0
Yoga as a Complementary Therapy for Cancer Patients: From Clinical Observations to Biochemical Mechanisms. 瑜伽作为癌症患者的辅助疗法:从临床观察到生化机制。
IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-01-01 Epub Date: 2024-07-18 DOI: 10.1159/000540213
Stéphanie Blockhuys, Pernilla Wittung-Stafshede

Background: Integrative oncology combines conventional and complementary, or integrative, therapies for a holistic treatment of cancer patients. Yoga is increasingly used as a complementary therapy for cancer patients, but there is no direct evidence for its effect on cancer pathophysiology like tumor response, or patient outcome like overall survival.

Summary: In this narrative review, we present in detail published studies from randomized clinical trials on complementary yoga therapy for cancer patients, including details about the biochemical mechanisms involved. Medicinal hatha yoga with breathing, postures, meditation, and relaxation enhances the quality of life of cancer patients by providing both psychological and physiological health benefits, highlighting the interconnectedness of mind and body. Yoga therapy reduces stress levels improving heart rate variability, leading to changes in hormonal regulation (e.g., cortisol), reduced oxidative stress, and improved immune function with reduced inflammation. Still, the biochemical effects of yoga on the cancer disease itself are unrevealed.

Key messages: More clinical and basic research is needed for further establishment of yoga as complementary therapy in oncology.

背景:中西医结合肿瘤学将传统疗法和辅助疗法或综合疗法结合起来,对癌症患者进行整体治疗。瑜伽越来越多地被用作癌症患者的辅助疗法,但目前还没有直接证据表明瑜伽对肿瘤反应等癌症病理生理学或总生存期等患者预后的影响。摘要:在这篇叙述性综述中,我们详细介绍了已发表的关于癌症患者辅助瑜伽疗法的随机临床试验研究,包括其中涉及的生化机制细节。药用哈达瑜伽包括呼吸、体位、冥想和放松,可提高癌症患者的生活质量,为心理和生理健康带来益处,突出了身心的相互关联性。瑜伽疗法可降低压力水平,改善心率变异性,从而改变荷尔蒙调节(如皮质醇),减少氧化应激,改善免疫功能,减少炎症。然而,瑜伽对癌症疾病本身的生化影响尚未揭示:关键信息:要进一步将瑜伽确立为肿瘤学的辅助疗法,还需要更多的临床和基础研究。
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引用次数: 0
Exploring Traditional Medicine Diagnostic Classification for Parkinson's Disease Using Hierarchical Clustering. 利用层次聚类探索帕金森病的传统医学诊断分类。
IF 1.8 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-01-01 Epub Date: 2024-02-08 DOI: 10.1159/000536047
HuiYan Zhao, Ojin Kwon, Jiyun Cha, In Chul Jung, Purumea Jun, Jae Young Jang, Jung-Hee Jang
<p><strong>Introduction: </strong>Personalized diagnosis and therapy for Parkinson's disease (PD) are needed due to the clinical heterogeneity of PD. Syndrome differentiation (SD) in traditional medicine (TM) is a diagnostic method for customized therapy that comprehensively analyzes various symptoms and systemic syndromes. However, research identifying PD classification based on SD is limited.</p><p><strong>Methods: </strong>Ten electronic databases were systematically searched from inception to August 10, 2021. Clinical indicators, including 380 symptoms, 98 TM signs, and herbal medicine for PD diagnosed with SD, were extracted from 197 articles; frequency statistics on clinical indicators were conducted to classify several subtypes using hierarchical clustering.</p><p><strong>Results: </strong>Four distinct cluster groups were identified, each characterized by significant cluster-specific clinical indicators with 95% confidence intervals of distribution. Subtype 2 had the most severe progression, longest progressive duration, and highest association with greater late-stage PD-associated motor symptoms, including postural instability and gait disturbance. The action properties of the herbal formula and original SD presented in the data sources for subtype 2 were associated with Yin deficiency syndrome.</p><p><strong>Discussion/conclusion: </strong>Hierarchical clustering analysis distinguished various symptoms and TM signs among patients with PD. These newly identified PD subtypes may optimize the diagnosis and treatment with TM and facilitate prognosis prediction. Our findings serve as a cornerstone for evidence-based guidelines for TM diagnosis and treatment.</p><p><p><title>Einleitung</title>Eine personalisierte Diagnose und Therapie des Morbus Parkinson (MP) ist angesichts der ausgeprägten klinischen Heterogenität des MP unerlässlich. Die Syndromdifferenzierung (SD) ist in der traditionellen Medizin (TM) eine diagnostische Methode für eine maßgeschneiderte Therapie, bei der verschiedene Symptome und systemische Syndrome umfassend analysiert werden. Es liegen jedoch nur begrenzt Forschungsergebnisse in Bezug auf eine SD-basierte Klassifikation des MP vor.<title>Methoden</title>Zehn elektronische Datenbanken wurden systematisch durchsucht, von der Einrichtung bis zum 10. August 2021. Klinische Indikatoren einschließlich von 380 Symptomen, 98 TM-Zeichen sowie pflanzlichen Heilmitteln für mittels SD diagnostiziertem MP wurden aus 197 Artikeln extrahiert, und Häufigkeitsstatistiken der klinischen Indikatoren wurden erstellt, um mittels hierarchischem Clustering eine Reihe von Subtypen zu klassifizieren.<title>Ergebnisse</title>Vier verschiedene Cluster-Gruppen wurden identifiziert, die jeweils durch signifikante, Cluster-spezifische klinische Indikatoren mit 95% Konfidenzintervall der Verteilung gekennzeichnet waren. Subtyp 2 hatte den schwersten Verlauf, die längste Progressionsdauer und die stärkste Assoziation mit einem höheren Ausmaß von mot
导言:由于帕金森病(PD)的临床异质性,需要对其进行个性化诊断和治疗。传统医学(TM)中的综合征分型(SD)是一种综合分析各种症状和系统综合征的诊断方法,可用于定制化治疗。然而,基于SD对PD进行分类的研究还很有限:方法:系统检索了从开始到 2021 年 8 月 10 日的 10 个电子数据库。从197篇文章中提取了临床指标,包括380个症状、98个TM体征,以及诊断为SD的PD的中药;对临床指标进行频数统计,采用分层聚类法对几个亚型进行分类:结果:发现了四个不同的聚类组,每个组都有显著的特定临床指标,其分布的置信区间为95%。亚型2的病情发展最严重,进展持续时间最长,与晚期帕金森病相关运动症状(包括姿势不稳和步态障碍)的关联度最高。亚型2数据源中的中药配方和原始SD的作用特性与阴虚综合征有关:分层聚类分析区分了PD患者的各种症状和TM体征。这些新发现的 PD 亚型可优化 TM 的诊断和治疗,并有助于预后预测。我们的研究结果可作为 TM 诊断和治疗循证指南的基石。
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引用次数: 0
The Use of Evening Primrose Oil for Cervical Ripening in Low-Risk Women with Term Pregnancy: A Randomized Double-Blinded Controlled Trial. 使用月见草油促进低风险足月妊娠妇女宫颈成熟:随机双盲对照试验
IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-01-01 Epub Date: 2024-02-20 DOI: 10.1159/000535585
Shideh Ariana, Nooshin Amjadi, Seyyedeh Neda Kazemi, Zahra Ahmadli
<p><strong>Background: </strong>Several methods have been developed for cervical ripening. The data regarding the efficiency of evening primrose oil (EPO) are inconsistent. The purpose of this study was to investigate the outcomes of EPO use on cervical ripening in low-risk women with term pregnancy.</p><p><strong>Patients and methods: </strong>Low-risk term pregnant women referred to the obstetrics clinic of Imam Hossein Hospital in Tehran who were eligible according to the inclusion were randomized either to the case or control group. The case group received 1,000 mg vaginal EPO capsule, and the other group received a vaginal placebo capsule daily, similar to the original drug. The primary outcome was Bishop score, while the duration of labor phases and the inducing procedures were the secondary outcomes.</p><p><strong>Results: </strong>Forty-eight participants were randomized to each group and were considered for data analysis. Although Bishop score was not statistically different before the intervention, it was significantly higher in case group compared to the placebo group after the intervention (EPO = 5.83 ± 1.68, placebo = 5.19 ± 1.52, p value = 0.002). Four participants in the case group and two in the control group underwent cesarean section (p value = 0.677). The need for labor induction was significantly higher in the placebo group than EPO group (oxytocin injection: 10.4% vs. 31.3%, p value = 0.012, amniotomy: 75% vs. 41.7, p value = 0.001).</p><p><strong>Conclusion: </strong>The vaginal use of EPO could be considered as a safe and efficient approach for cervical ripening in low-risk term pregnant women.</p><p><p><title>Hintergrund</title>Es wurden verschiedene Methoden zur Zervixreifung entwickelt. Die Daten zur Wirksamkeit von Nachtkerzenöl (evening primrose oil, EPO) sind uneinheitlich. Mit dieser Studie sollen die Ergebnisse der Anwendung von EPO zur Zervixreifung bei Frauen mit niedrigem Risiko und termingerechter Schwangerschaft untersucht werden.<title>Patientinnen und Methoden</title>Schwangere Frauen mit niedrigem Risiko und termingerechter Schwangerschaft, die in die Geburtsklinik des Imam-Hossein-Krankenhauses in Teheran eingewiesen wurden und gemäss den Einschlusskriterien für die Teilnahme infrage kamen, wurden randomisiert der Fall- oder der Kontrollgruppe zugewiesen. Die Fallgruppe erhielt 1.000 mg EPO als Vaginalkapseln, während die andere Gruppe täglich eine vaginale Placebokapsel erhielt, die dem Originalpräparat ähnelte. Primäres Zielkriterium war der Bishop-Score und sekundäre Zielkriterien waren die Dauer der Wehenphasen sowie die Verfahren zur Geburtseinleitung.<title>Ergebnisse</title>Jeder Gruppe wurden randomisiert 48 Teilnehmerinnen zugewiesen und bei der Datenanalyse berücksichtigt. Während vor der Intervention kein statistisch signifikanter Unterschied im Bishop-Score bestand, fiel dieser nach der Intervention in der Fallgruppe signifikant höher aus als in der Placebogruppe (EPO = 5,83 ± 1,68, Placebo = 5,
背景:目前已开发出多种宫颈成熟的方法。有关月见草油(EPO)功效的数据并不一致。本研究旨在调查使用月见草油对低风险足月妊娠妇女宫颈成熟的效果:德黑兰伊玛目侯赛因医院产科诊所转诊的低风险足月妊娠妇女,符合纳入条件者被随机分为病例组和对照组。病例组每天服用 1000 毫克阴道 EPO 胶囊,另一组每天服用与原药相似的阴道安慰剂胶囊。主要结果为Bishop评分,次要结果为产程持续时间和引产过程:48名参与者被随机分为两组,并被纳入数据分析。虽然干预前 Bishop 评分没有统计学差异,但干预后病例组的 Bishop 评分明显高于安慰剂组(EPO= 5.83 ± 1.68,安慰剂= 5.19 ± 1.52,P 值= 0.002)。病例组和对照组分别有 4 人和 2 人接受了剖宫产手术(P 值= 0.677)。安慰剂组的引产需求明显高于 EPO 组(催产素注射:10.4% 对 31.3%,p 值= 0.002):10.4% vs 31.3%,p-value= 0.012;羊膜切开术:75% vs 41.7,p-value= 0.001):结论:阴道使用 EPO 可被视为低风险足月孕妇宫颈成熟的一种安全有效的方法。
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引用次数: 0
Effect of Music-Based Interventions on Maternal and Fetal Parameters during Pregnancy: A Systematic Review. 音乐干预对孕期母体和胎儿参数的影响:系统回顾
IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-01-01 Epub Date: 2024-08-22 DOI: 10.1159/000540263
Aliye Dogan-Gangal, Belgin Akin, Deniz Kocoglu-Tanyer

Introduction: Music is a non-pharmacological intervention often used to improve maternal mental health during pregnancy. However, there is limited evidence regarding the effectiveness of music-based interventions on maternal and fetal parameters during pregnancy. We present a systematic review of the available research literature on the effects of music interventions on maternal and fetal parameters.

Methods: A comprehensive literature search was conducted on the Web of Science, PubMed, ScienceDirect, Scopus, CINAHL, MEDLINE, Cochrane, ProQuest, and Turkish databases. The review included randomized controlled and quasi-experimental studies. Two independent authors evaluated the methodological quality of each study using the Quality Assessment Tool for Quantitative Studies. The study was registered in PROSPERO (CRD42018102914).

Results: The literature review yielded a total of 723 studies. Among these studies, 13 were included in this study. Most of the studies involving low-risk pregnant women reported that music had no effect on stress but reduced anxiety and depression. The effect of music on pregnant women's blood pressure varied depending on the presence of medical conditions that could affect their blood pressure. While some studies showed that music interventions effectively increased fetal movement and acceleration, the available findings were limited.

Conclusion: Healthcare professionals can use simple, cost-effective, and practical music interventions to improve maternal mental health during pregnancy without neglecting medical treatment. Future well-designed studies are recommended to investigate the effects of music on maternal psychological, physiological parameters and fetal parameters in high-risk pregnancies.

简介音乐是一种非药物干预措施,常用来改善孕期孕产妇的心理健康。然而,关于音乐干预对孕期孕产妇和胎儿参数的有效性的证据却很有限。我们对现有关于音乐干预对母体和胎儿参数影响的研究文献进行了系统性回顾:我们在 Web of Science、PubMed、Science Direct、Scopus、CINAHL、Medline、Cochrane、ProQuest 和 Turkish 数据库中进行了全面的文献检索。综述包括随机对照研究和准实验研究。两位独立作者使用定量研究质量评估工具对每项研究的方法学质量进行了评估。该研究已在 PROSPERO(CRD42018102914)上注册:结果:文献综述共收集到 723 项研究。结果:文献综述共收集到 723 项研究,其中 13 项被纳入本研究。大多数涉及低风险孕妇的研究报告称,音乐对压力没有影响,但能减轻焦虑和抑郁。音乐对孕妇血压的影响因孕妇是否患有可能影响血压的疾病而异。虽然一些研究表明音乐干预能有效增加胎动和加速,但现有研究结果有限:结论:医护人员可以使用简单、经济、实用的音乐干预措施来改善孕期孕产妇的心理健康,同时又不会忽视医疗。建议今后开展精心设计的研究,探讨音乐对高危妊娠中孕产妇心理、生理参数和胎儿参数的影响。
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引用次数: 0
Low Inter-Rater Reliability and Reproducibility of Neck Reflex/"Adler-Langer" Points in Neural Therapy Diagnostics but Increased Pressure Pain Threshold after Therapy: Results of a Randomized Controlled Observer-Blind Trial. 神经疗法诊断中颈部反射/"阿德勒-朗格 "点的评分者间可靠性和可重复性较低,但治疗后压力-疼痛阈值提高--随机对照观察者-盲法试验结果。
IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-01-01 Epub Date: 2024-05-14 DOI: 10.1159/000539230
Kyung-Eun Choi, Jan Grünert, Marc Werner, Holger Cramer, Dennis Anheyer, Gustav Dobos, Felix J Saha

Background: Neck reflex points or Adler-Langer points are commonly used in neural therapy to detect so-called interference fields. Chronic irritations or inflammations in the sinuses, teeth, tonsils, or ears are supposed to induce tension and tenderness of the soft tissues and short muscles in the upper cervical spine. The individual treatment strategy is based on the results of diagnostic Adler-Langer point palpation. This study investigated the inter- and intra-rater reliability and explored treatment effects.

Methods: We performed a randomized controlled trial with 104 inpatients (80.8% female, 51.8 ± 12.74 years) of a German department for internal and integrative medicine. Patients were randomized to individual neural therapy according to the pathological findings (n = 48) or no treatment (n = 56). In each patient, three experienced raters (20-45 years of experience in neural therapy) and two novice raters (medical students) rated Adler-Langer points rigidity on a standardized rating scale ("strong," "weak," "none"). The patients independently evaluated the tenderness on palpation of the eight points using the same scale. Pressure pain thresholds were assessed at the eight Adler-Langer points. All patients were retested after 30 min. The five raters were blinded to treatment allocation and assessments of the other raters. Video recordings were obtained to assess the consistency of the areas tested by the different raters.

Results: Agreement between patients and raters (Cohen's kappa = 0.161-0.400) and inter-rater reliability were low (Fleiss kappa = 0.132-0.150). Moreover, the individual agreement (pre-post comparisons in untreated patients) was similarly low even in experienced raters (Cohen's kappa = 0.099-0.173). Video documentation suggests that raters do not place their fingers in the correct segments (percentage of correct position: 42.0-60.6%). Pressure pain thresholds at five of the eight Adler-Langer points showed significant changes after treatment compared to none in the control group.

Conclusion: Under this artificial experimental setting, this method of Adler-Langer point palpation has not proven to be a reliable diagnostic tool. But it could be shown that, as claimed by the method, the tenderness in five of eight Adler-Langer points decreased after neural therapy.

背景介绍颈部反射点或阿德勒-朗格点通常用于神经疗法,以检测所谓的干扰场。鼻窦、牙齿、扁桃体或耳朵的慢性刺激或炎症会引起上颈椎软组织和短肌肉的紧张和疼痛。个人治疗策略以诊断性阿德勒-朗格穴触诊结果为基础。本研究调查了评分者之间和评分者内部的可靠性,并探讨了治疗效果:我们对德国一家内科和综合科的 104 名住院患者(80.8% 为女性,51.812.74 岁)进行了随机对照试验。患者根据病理结果随机接受个体神经疗法(48 人)或不接受治疗(56 人)。每名患者均由三名经验丰富的评定者(神经疗法经验 20-45 年)和两名新手评定者(医科学生)根据标准化评分表("强"、"弱"、"无")对阿德勒-朗格穴僵硬度进行评分。患者使用相同的量表独立评估触诊八个穴位时的压痛感。对八个阿德勒-朗格穴的压痛阈值进行评估。30 分钟后对所有患者进行复测。五位评定者对治疗分配和其他评定者的评定结果都是盲测。为评估不同评分者测试区域的一致性,还进行了录像:患者与评分者之间的一致性(Cohen's Kappa=.161-.400)和评分者之间的可靠性均较低(Fleiss-Kappa=.132-.150)。此外,即使是经验丰富的评分员,其个人一致性(未经治疗患者的前后比较)也同样较低(科恩卡帕=.099-.173)。视频记录表明,评分者并没有将手指放在正确的区段(正确位置百分比为 42.0-60.6%)。八个阿德勒-朗格穴中有五个穴位的压痛阈值在治疗后出现了显著变化,而对照组则没有:在这种人工实验环境下,阿德勒-朗格穴触诊法并未被证明是一种可靠的诊断工具。但可以证明的是,正如该方法所声称的那样,经过神经疗法后,八个阿德勒-朗格穴中有五个穴位的压痛有所减轻。
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引用次数: 0
Forest Therapy as a Nature-Based Intervention: An Option for Neurological Rehabilitation? 森林疗法作为一种基于自然的干预:神经康复的选择?
IF 1.8 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-01-01 Epub Date: 2023-10-12 DOI: 10.1159/000534533
Josef G Heckmann, Martin Kiem, Gisela Immich
<p><strong>Background: </strong>Forest therapy demonstrates positive effects on mood, immune system, stress levels, and general well-being. Studies on depression, stress-related illnesses, sleep disorders, and arterial hypertension have provided evidence-based proof of this.</p><p><strong>Summary: </strong>The aim of this review was to examine the possible effects of forest therapy with regard to its evidence in the treatment of chronic neurological diseases such as stroke in the rehabilitation phase, Parkinson's disease, dementia, and multiple sclerosis. Therefore, the electronic databases Medline, Scopus, and Cochrane were searched for such clinical trials for the years 1970 to mid-2023 without language restriction. The literature search revealed only few studies with positive indications but too few cases to be able to make generalizable evidence-based statements. In terms of improvement in the Hamilton Depression Scale analysis of two studies in stroke patients showed slight benefits in the forest therapy group (standard mean difference -0.43; 95% CI: -0.76 to -0.10; p < 0.01). One observational study revealed a higher rate of stroke survival in patients living in marked greenness. Few nature-based interventions in dementia patients showed certain benefits in particular details.</p><p><strong>Key messages: </strong>There are no evidence-based results on the benefit of forest therapy for chronic neurological diseases. However, there are hints that forest therapy could have a positive benefit. Therefore, a proposal for forest therapy as a component of multimodal neurological rehabilitation is presented.</p><p><p><title>Hintergrund</title>Die Waldtherapie zeigt positive Auswirkungen auf die Stimmung, das Immunsystem, das Stressniveau und das allgemeine Wohlbefinden. Studien zu Depressionen, stressbedingten Erkrankungen, Schlafstörungen und arteriellem Bluthochdruck haben dies evidenzbasiert belegt.<title>Zusammenfassung</title>Ziel dieser Übersichtsarbeit war es, die möglichen Wirkungen der Waldtherapie im Hinblick auf ihre Evidenz bei der Behandlung chronischer neurologischer Erkrankungen wie Schlaganfall in der Rehabilitationsphase, Morbus Parkinson, Demenz und Multiple Sklerose zu untersuchen. Dazu wurden die elektronischen Datenbanken Medline, Scopus und Cochrane für die Jahre 1970 bis Mitte 2023 ohne sprachliche Einschränkung nach solchen klinischen Studien durchsucht. Die Literaturrecherche ergab nur wenige Studien mit positiven Indikationen, aber zu wenigen Fällen, um verallgemeinerbare evidenzbasierte Aussagen machen zu können. Im Hinblick auf Verbesserung in der Hamilton Depressionsskala zeigte die Analyse von 2 Studien bei Schlaganfallpatienten leichte Vorteile der Waldtherapiegruppen (Standard Mean Difference −0.43; 95% CI: -0.76- -0,10; <italic>p</italic> < 0.01). Eine Beobachtungsstudie ergab eine höhere Schlaganfall-Überlebensrate bei Patienten, die in ausgeprägtem Grün leben. Einige naturbasierte Interventionen bei Demenzpat
背景:森林疗法对情绪、免疫系统、压力水平和总体健康有积极影响。对抑郁症、压力相关疾病、睡眠障碍和动脉高压的研究已经提供了循证证据。综述:本综述的目的是研究森林疗法在治疗慢性神经系统疾病方面的可能效果,如康复期中风、帕金森病、痴呆症和多发性硬化症。因此,在电子数据库Medline、Scopus和Cochrane中搜索了1970年至2023年年中的此类临床试验,没有语言限制。文献检索显示,只有少数研究具有积极的适应症,但病例太少,无法做出普遍的循证声明。就汉密尔顿抑郁量表的改善而言,对两项针对中风患者的研究的分析显示,森林治疗组略有益处(标准平均差-0.43;95%置信区间-0.76--0.10;p关键信息:森林疗法对慢性神经系统疾病的益处没有循证结果。然而,有迹象表明森林疗法可能具有积极的益处。因此,提出了将森林疗法作为多模式神经康复的一个组成部分的建议。
{"title":"Forest Therapy as a Nature-Based Intervention: An Option for Neurological Rehabilitation?","authors":"Josef G Heckmann, Martin Kiem, Gisela Immich","doi":"10.1159/000534533","DOIUrl":"10.1159/000534533","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Forest therapy demonstrates positive effects on mood, immune system, stress levels, and general well-being. Studies on depression, stress-related illnesses, sleep disorders, and arterial hypertension have provided evidence-based proof of this.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Summary: &lt;/strong&gt;The aim of this review was to examine the possible effects of forest therapy with regard to its evidence in the treatment of chronic neurological diseases such as stroke in the rehabilitation phase, Parkinson's disease, dementia, and multiple sclerosis. Therefore, the electronic databases Medline, Scopus, and Cochrane were searched for such clinical trials for the years 1970 to mid-2023 without language restriction. The literature search revealed only few studies with positive indications but too few cases to be able to make generalizable evidence-based statements. In terms of improvement in the Hamilton Depression Scale analysis of two studies in stroke patients showed slight benefits in the forest therapy group (standard mean difference -0.43; 95% CI: -0.76 to -0.10; p &lt; 0.01). One observational study revealed a higher rate of stroke survival in patients living in marked greenness. Few nature-based interventions in dementia patients showed certain benefits in particular details.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Key messages: &lt;/strong&gt;There are no evidence-based results on the benefit of forest therapy for chronic neurological diseases. However, there are hints that forest therapy could have a positive benefit. Therefore, a proposal for forest therapy as a component of multimodal neurological rehabilitation is presented.&lt;/p&gt;&lt;p&gt;&lt;p&gt;&lt;title&gt;Hintergrund&lt;/title&gt;Die Waldtherapie zeigt positive Auswirkungen auf die Stimmung, das Immunsystem, das Stressniveau und das allgemeine Wohlbefinden. Studien zu Depressionen, stressbedingten Erkrankungen, Schlafstörungen und arteriellem Bluthochdruck haben dies evidenzbasiert belegt.&lt;title&gt;Zusammenfassung&lt;/title&gt;Ziel dieser Übersichtsarbeit war es, die möglichen Wirkungen der Waldtherapie im Hinblick auf ihre Evidenz bei der Behandlung chronischer neurologischer Erkrankungen wie Schlaganfall in der Rehabilitationsphase, Morbus Parkinson, Demenz und Multiple Sklerose zu untersuchen. Dazu wurden die elektronischen Datenbanken Medline, Scopus und Cochrane für die Jahre 1970 bis Mitte 2023 ohne sprachliche Einschränkung nach solchen klinischen Studien durchsucht. Die Literaturrecherche ergab nur wenige Studien mit positiven Indikationen, aber zu wenigen Fällen, um verallgemeinerbare evidenzbasierte Aussagen machen zu können. Im Hinblick auf Verbesserung in der Hamilton Depressionsskala zeigte die Analyse von 2 Studien bei Schlaganfallpatienten leichte Vorteile der Waldtherapiegruppen (Standard Mean Difference −0.43; 95% CI: -0.76- -0,10; &lt;italic&gt;p&lt;/italic&gt; &lt; 0.01). Eine Beobachtungsstudie ergab eine höhere Schlaganfall-Überlebensrate bei Patienten, die in ausgeprägtem Grün leben. Einige naturbasierte Interventionen bei Demenzpat","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"56-63"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41193814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gegen Qinlian Decoction Combined with Conventional Western Medicine for the Treatment of Infectious Diarrhea: A Systematic Review and Trial Sequential Analysis. 格根秦连煎联合常规西药治疗感染性腹泻:系统回顾与试验序列分析》。
IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-01-01 Epub Date: 2024-08-13 DOI: 10.1159/000540793
Fei Wang, Qianyan Wu, Qingyuan Zhang, Shuaishuai Ma, Kangyi Wang, Hui Jian, Ying Zhang

Introduction: Infectious diarrhea (ID) is a highly prevalent disease worldwide that poses a substantial risk to human well-being. In China, numerous clinical studies have investigated the efficacy of Gegen Qinlian decoction (GGQLD) in treating ID. However, there is a need for additional rigorous and evidence-based medical research to enhance physicians' confidence in their prescribing practices.

Methods: Seven Chinese and English databases were systematically searched. The Cochrane Risk of Bias tool was used to assess the quality of the included studies. Meta-analysis was conducted using RevMan 5.3, and Stata 16.0 was used for the sensitivity analysis. Trial sequential analysis was performed using TSA v0.9, and GRADEprofiler was utilized to evaluate the quality of evidence.

Results: A total of 12 randomized controlled trials (RCTs) involving 1,240 patients were included. The meta-analysis demonstrated that the combination of GGQLD with conventional Western medicine had better effects on clinical efficacy (relative risk [RR] = 1.15, 95% confidence interval [CI] [1.10, 1.20]), duration of diarrhea symptoms (weighted mean difference [WMD] = -10.96, 95% CI [-11.97, -9.96]), duration of abdominal pain symptoms (WMD = -12.01, 95% CI [-14.12, -9.90]), duration of fever symptoms (WMD = -11.91, 95% CI [-13.39, -10.43]), interleukin-6 levels (WMD = -113.59, 95% CI [-113.03, -108.14]), and tumor necrosis factor-α levels (WMD = -62.18, 95% CI [-65.25, -59.11]) and that no significant adverse reactions occurred (RR = 0.45, 95% CI [0.10, 1.97]). The sample size of the included studies reached the expected size. The quality of evidence for outcome indicators was rated as low or very low.

Conclusions: The combination of GGQLD with conventional Western medicine demonstrates promising efficacy and safety in treating ID. Nonetheless, more high-quality RCTs are required to confirm this conclusion.

背景:感染性腹泻(ID)是一种全球高发疾病,对人类健康构成了巨大威胁。在中国,许多临床研究都探讨了格根秦连煎(GGQLD)治疗感染性腹泻的疗效。然而,还需要更多严格的循证医学研究,以增强医生的处方信心:方法:系统检索了七个中英文数据库。方法:系统检索了 7 个中英文数据库,并使用 Cochrane Risk of Bias 工具评估纳入研究的质量。使用 RevMan 5.3 进行 Meta 分析,使用 Stata 16.0 进行敏感性分析。使用TSA v0.9进行试验序列分析,并使用GRADEprofiler评估证据质量:共纳入了 12 项随机对照试验(RCT),涉及 1240 名患者。荟萃分析表明,GGQLD与常规西药联合治疗在临床疗效(RR=1.15,95% CI [1.10,1.20])、腹泻症状持续时间(WMD=-10.96,95% CI [-11.97,-9.96])、腹痛症状持续时间(WMD=-12.01,95% CI [-14.12,-9.90])、发热症状持续时间(WMD=-11.91,95% CI [-13.39,-10.43])、白细胞介素-6(IL-6)水平(WMD=-113.59,95% CI [-113.03,-108.14])和肿瘤坏死因子-α(TNF-α)水平(WMD=-62.18,95% CI[-65.25,-59.11]),且未出现明显的不良反应(RR = 0.45,95% CI [0.10,1.97])。纳入研究的样本量达到了预期规模。结果指标的证据质量被评为低或很低:结论:GGQLD与传统西药联合治疗ID具有良好的疗效和安全性。尽管如此,还需要更多高质量的 RCT 研究来证实这一结论。
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引用次数: 0
Investigation of Herbal Therapy Methods Used by Parents of Children with Cancer for Symptom Management in Chemotherapy Process. 癌症患儿家长在化疗过程中使用草药治疗方法控制症状的调查。
IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-01-01 Epub Date: 2024-10-04 DOI: 10.1159/000541708
Nurcan Erbay, Nejla Canbulat Sahiner, Mehmet Fatih Aydın

Introduction: The number of types of cancer, which is the leading severe health problem and is frequently seen in childhood period, has steadily increased over the years. This descriptive and cross-sectional study was conducted to determine the herbal treatment methods used by parents of children with cancer during the chemotherapy process for symptom management.

Methods: The study was carried out with the parents of 126 children diagnosed with cancer. The data were collected with a questionnaire form created in line with the literature and the form for the amount and frequency of use of herbal treatment methods used by parents. The data were evaluated with descriptive statistics and χ2 test.

Results: The mean age of the children included in the study was 8.08 ± 3.15 (min = 3, max = 17) years, and the mean duration of diagnosis was 14.35 ± 13.22 (min = 6, max = 60) months. 78.6% (n = 99) of the parents included in the study stated that they used herbal treatment for the treatment of their child's disease. 79.4% (n = 100) of the parents thought that the herbal treatment they used was effective. The first reason (48.4%, n = 61) for using herbal treatment was "to do everything we could for the treatment."

Conclusion: It was determined that the use of herbal treatment methods was related to the mother's profession, the education level of the parents, and the place of residence. In particular, it is necessary to inform parents about herbal treatment methods through nurses with up-to-date information and to create the right attitude toward this issue.

导 言癌症是儿童时期常见的严重健康问题,其类型数量近年来稳步增加。这项描述性横断面研究旨在了解癌症患儿父母在化疗过程中为控制症状而使用的草药治疗方法:研究对象为 126 名癌症患儿的家长。根据文献和家长使用草药治疗方法的数量和频率制作的调查表收集数据。通过描述性统计和卡方检验对数据进行了评估:参与研究的儿童平均年龄为(8.08±3.15)岁(最小=3 岁,最大=17 岁),平均诊断时间为(14.35±13.22)个月(最小=6 个月,最大=60 个月)。78.6%(n=99)的参与研究的家长表示,他们使用中草药治疗孩子的疾病。79.4%(n=100)的家长认为他们使用的中草药治疗有效。使用中草药治疗的首要原因(48.4%,n=61)是 "尽一切可能进行治疗":结论:使用草药治疗方法与母亲的职业、父母的教育水平和居住地有关。特别是,有必要通过护士向家长介绍草药治疗方法的最新信息,并树立对这一问题的正确态度。
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引用次数: 0
Severe Itch Related to Hard Workload Treated with Acupuncture: Unexpected Results - A Case report. 针灸治疗与工作量大有关的严重瘙痒。意想不到的效果。病例报告。
IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-01-01 Epub Date: 2024-09-02 DOI: 10.1159/000541191
Lisbeth Dahlin, Anja Finn

Introduction: The effects of work-related stress (WRS) on occupational health often lead to reduced well-being and long-term sick leave. Itching or pruritus, a skin inflammation with a rash that provokes the desire to scratch, often occurs during stressful periods in patients with a history of atopic dermatitis (AD).

Case presentation: This patient suffered from severe WRS together with long-term therapeutically resistant pruritus for 8 years, resulting in severe itching. He was provided with an intervention with acupuncture treatment (AT) to prevent a long-term sick leave. The results showed an unexpected reduction in itching, skin inflammation, and eczema. Additionally, the treatment enhanced the patient's emotional and cognitive well-being and eliminated the need for sick leave.

Conclusion: Acupuncture can be an effective complementary treatment for severe itching related to WRS, in addition to standard medical treatments.

简介与工作有关的压力(WRS)对职业健康的影响往往会导致幸福感下降和长期病假。瘙痒或瘙痒症是一种皮肤炎症,伴有皮疹,会引起搔抓的欲望,经常发生在有特应性皮炎(AD)病史的患者身上:病例介绍:这位患者患有严重的 WRS,并伴有长期治疗耐受性瘙痒症,导致严重瘙痒长达八年之久。为了防止长期病假,他接受了针灸治疗(AT)干预。结果显示,瘙痒、皮肤炎症和湿疹出乎意料地减轻了。此外,治疗还增强了患者的情绪和认知能力,使其不再需要请病假:结论:针灸可作为标准医疗方法之外的一种有效辅助治疗方法,用于治疗与 WRS 相关的严重瘙痒。
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引用次数: 0
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Complementary Medicine Research
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