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Effect of Music-Based Interventions on Maternal and Fetal Parameters during Pregnancy: A Systematic Review. 音乐干预对孕期母体和胎儿参数的影响:系统回顾
IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-08-22 DOI: 10.1159/000540263
Aliye Dogan-Gangal, Belgin Akin, Deniz Kocoglu-Tanyer

Introduction: Music is a non-pharmacological intervention often used to improve maternal mental health during pregnancy. However, there is limited evidence regarding the effectiveness of music-based interventions on maternal and fetal parameters during pregnancy. We present a systematic review of the available research literature on the effects of music interventions on maternal and fetal parameters.

Methods: A comprehensive literature search was conducted on the Web of Science, PubMed, ScienceDirect, Scopus, CINAHL, MEDLINE, Cochrane, ProQuest, and Turkish databases. The review included randomized controlled and quasi-experimental studies. Two independent authors evaluated the methodological quality of each study using the Quality Assessment Tool for Quantitative Studies. The study was registered in PROSPERO (CRD42018102914).

Results: The literature review yielded a total of 723 studies. Among these studies, 13 were included in this study. Most of the studies involving low-risk pregnant women reported that music had no effect on stress but reduced anxiety and depression. The effect of music on pregnant women's blood pressure varied depending on the presence of medical conditions that could affect their blood pressure. While some studies showed that music interventions effectively increased fetal movement and acceleration, the available findings were limited.

Conclusion: Healthcare professionals can use simple, cost-effective, and practical music interventions to improve maternal mental health during pregnancy without neglecting medical treatment. Future well-designed studies are recommended to investigate the effects of music on maternal psychological, physiological parameters and fetal parameters in high-risk pregnancies.

简介音乐是一种非药物干预措施,常用来改善孕期孕产妇的心理健康。然而,关于音乐干预对孕期孕产妇和胎儿参数的有效性的证据却很有限。我们对现有关于音乐干预对母体和胎儿参数影响的研究文献进行了系统性回顾:我们在 Web of Science、PubMed、Science Direct、Scopus、CINAHL、Medline、Cochrane、ProQuest 和 Turkish 数据库中进行了全面的文献检索。综述包括随机对照研究和准实验研究。两位独立作者使用定量研究质量评估工具对每项研究的方法学质量进行了评估。该研究已在 PROSPERO(CRD42018102914)上注册:结果:文献综述共收集到 723 项研究。结果:文献综述共收集到 723 项研究,其中 13 项被纳入本研究。大多数涉及低风险孕妇的研究报告称,音乐对压力没有影响,但能减轻焦虑和抑郁。音乐对孕妇血压的影响因孕妇是否患有可能影响血压的疾病而异。虽然一些研究表明音乐干预能有效增加胎动和加速,但现有研究结果有限:结论:医护人员可以使用简单、经济、实用的音乐干预措施来改善孕期孕产妇的心理健康,同时又不会忽视医疗。建议今后开展精心设计的研究,探讨音乐对高危妊娠中孕产妇心理、生理参数和胎儿参数的影响。
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引用次数: 0
Regional Perspectives on Complementary and Alternative Medicine: Results of a Regional Survey. 地区对补充和替代医学的看法:地区调查的结果。
IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-08-20 DOI: 10.1159/000540663
Mikael Källman, Stefan Bergström, Georg Holgersson, Jacob Järås, Ruth Randén Engqvist, Michael Bergqvist

Background: Complementary and alternative medicine (CAM) is widely used by patients with cancer. Research indicates that the use of CAM is more prevalent in rural areas compared to urban areas. There is currently a lack of information regarding the scope and specifics of CAM use among patients in Sweden, particularly in rural areas. The aim of this study was to estimate the extent and characteristics of CAM use among cancer patients in the rural areas of Region Gävleborg.

Methods: A total of 631 questionnaires were sent out, and 376 of those were returned, corresponding to a response rate of 59.6%. Oncology patients received questionnaires at their initial appointment for curative care at Gävle Hospital's Department of Oncology. When enrolling in palliative outpatient care in their homes, palliative patients were sought out. Standard descriptive statistics were used to present the characteristics of the respondents. To determine odds ratios and potential factors (age, gender, diagnosis, and education) affecting CAM use after cancer diagnosis, a multivariable logistic model was constructed.

Results: Based on clinical observations, the authors' hypothesis that CAM use is particularly common in small towns in the Hälsingland region was verified in this study. This was particularly pronounced among younger people and residents of small towns in the province of Halsingland. The higher level of CAM use appears to apply to both men and women.

Conclusions: CAM appears to be used more frequently by patients residing in rural areas. It is crucial that care providers enquire about all of the patient's health-seeking activities. Further research is needed on the usage of CAM in rural areas and the potential cultural influences contributing to CAM use. From a sociological standpoint, it is crucial to draw attention to the fact that CAM use may be more prevalent in certain rural areas, particularly in centralized societies where it is more difficult to access healthcare in remote regions.

背景:癌症患者广泛使用补充和替代医学(CAM)。有研究表明,与城市地区相比,农村地区使用 CAM 的情况更为普遍。关于瑞典(尤其是农村地区)患者使用 CAM 的范围和具体情况,目前还缺乏相关信息。本研究旨在估算耶夫勒堡地区农村地区癌症患者使用 CAM 的程度和特点:共发出 631 份问卷,收回 376 份,回复率为 59.6%。肿瘤患者在耶夫勒医院肿瘤科接受首次治疗预约时收到了调查问卷。姑息治疗患者在家中接受姑息治疗门诊服务时,以及在初次就诊时,都会收到调查问卷。我们使用标准的描述性统计来描述受访者的特征。为了确定癌症确诊后使用 CAM 的几率比(ORs)和潜在因素(年龄、性别、诊断和教育程度),构建了一个多变量逻辑模型:根据临床观察,作者的假设得到了验证,即补充和替代医学(CAM)的使用在海尔辛兰地区的小城镇尤为普遍。此外,大多数使用 CAM 的人都比较年轻,而且居住在海尔辛兰的小城镇。结论:结论:居住在农村地区的患者似乎更经常使用 CAM。照顾者必须询问病人的所有保健活动。有必要对农村地区使用补充和替代医学(CAM)的情况以及对这种使用的潜在文化影响开展进一步研究。从社会学的角度来看,至关重要的是要引起人们的注意,在一些农村地区,尤其是在集中化社会中,使用 CAM 的情况可能更为普遍,因为在这些地区获得医疗保健服务更为困难。
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引用次数: 0
Torkel Falkenberg *September 17th, 1962 to †July 9th, 2024. 托克尔-法肯伯格 *1962年9月17日至†2024年7月9日。
IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-08-13 DOI: 10.1159/000540742
Harald Walach
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引用次数: 0
Obituary - Torkel Falkenberg. 讣告 - Torkel Falkenberg.
IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-08-13 DOI: 10.1159/000540742
Harald Walach
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引用次数: 0
Effect of Long-Snake Moxibustion on Gut Microbiota of Patients with Ankylosing Spondylitis. 长蛇灸对强直性脊柱炎患者肠道微生物群的影响
IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-08-09 DOI: 10.1159/000540271
Xijing Yu, Mengyu Jin, Hui Huang, Fenfen Qiu, Lele Geng, Rong Guo, Xiaoyan Zhu, Xiuwu Hu

Objective: The objectively was to study the effect of long-snake moxibustion intervention on gut microbiota of patients with ankylosing spondylitis (AS) by 16S rDNA sequencing technology.

Methods: Thirty AS patients and 30 healthy volunteers were recruited and treated with long-snake moxibustion once a week for 12 weeks. AS patients were divided into pretreatment and posttreatment groups. VAS, BASDAI, and BASFI scores of AS patients before and after treatment were collected. 16S rDNA high-throughput sequencing technology was used to analyze the characteristics and differences of gut microbiota in AS patients before and after treatment and in healthy volunteers.

Results: VAS, BASDAI, and BASFI scores of AS patients after long-snake moxibustion treatment were lower than those of pretreatment group (p < 0.05). The results of gut microbiota alpha diversity showed that Ace and Chao1 index of the posttreatment group were higher than those of the health group (p < 0.05), but there was no statistical significance in Ace and Chao1 index between the pretreatment group and the posttreatment group (p > 0.05). Beta diversity analysis showed that mild classification aggregation occurred between the health group and the pretreatment group but did not reach a significant level, and there was no significant difference between the pretreatment group and the posttreatment group. The results of species abundance showed that, at the phylum level, compared with the health group, the relative abundance of Firmicutes and Proteobacteria decreased in the pretreatment group, while the relative abundance of Bacteroidetes and Actinobacteria increased. Compared with the pretreatment group, the relative abundance of Firmicutes increased and the relative abundance of Actinobacteria decreased in the posttreatment group, but there were no statistically significant differences in the above changes (p > 0.05). At the genus level, compared with the health group, the relative abundances of Subdoligranulum in the pretreatment group were increased (p < 0.05), while the relative abundances of Bifidobacterium and Streptococcus were decreased (p < 0.05). Compared with the pretreatment group, the relative abundance of Romboutsia in the posttreatment group was increased (p < 0.05).

Conclusion: Long-snake moxibustion can obviously improve the clinical symptoms of AS patients. The possible mechanism of action is related to regulating the abundance of gut microbiota, increasing beneficial bacteria, and restoring the homeostasis of gut microorganisms.

目的方法:招募30名强直性脊柱炎(AS)患者和30名健康志愿者,对其进行长蛇灸治疗,每周一次,连续12周。将 AS 患者分为治疗前和治疗后两组。收集治疗前后 AS 患者的 VAS、BASDAI 和 BASFI 评分。采用16S rDNA高通量测序技术分析了治疗前后强直性脊柱炎患者和健康志愿者肠道微生物群的特征和差异:结果:长蛇灸治疗后强直性脊柱炎患者的VAS、BASDAI和BASFI评分均低于治疗前(P<0.05)。肠道微生物群Alpha多样性结果显示,治疗后组的ace和chao1指数高于健康组(P<0.05),但治疗前组与治疗后组的ace和chao1指数差异无统计学意义(P>0.05)。Beta 多样性分析表明,健康组与处理前组之间存在轻度分类聚集,但未达到显著水平,处理前组与处理后组之间无显著差异。物种丰度结果表明,与健康组相比,在门的层次上,处理前组的固着菌和变形菌相对丰度下降,而类杆菌和放线菌相对丰度上升。与治疗前相比,治疗后组的固缩菌相对丰度增加,放线菌相对丰度减少,但上述变化差异无统计学意义(P>0.05)。在菌属水平上,与健康组相比,治疗前组 Subdoligranulum 的相对丰度升高(P<0.05),而双歧杆菌和链球菌的相对丰度降低(P<0.05)。与治疗前相比,治疗后组的隆突菌相对丰度增加(P<0.05):结论:长蛇灸能明显改善强直性脊柱炎患者的临床症状。结论:长蛇灸能明显改善强直性脊柱炎患者的临床症状,其作用机制可能与调节肠道微生物群的丰度、增加有益菌、恢复肠道微生物的平衡有关。
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引用次数: 0
What a Study Is about Should Be Clear. 研究的目的应该是明确的。
IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-06-10 DOI: 10.1159/000539409
Axel Wiebrecht
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引用次数: 0
Ayurveda for a Type 1 Diabetes Patient with Peripheral Arterial Occlusive Disease: A Case Report. 阿育吠陀治疗患有外周动脉闭塞性疾病(PAOD)的1型糖尿病患者。
IF 1.8 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-01-01 Epub Date: 2023-11-09 DOI: 10.1159/000534992
Elmar Stapelfeldt, Bettina Berger, Christa K Raak, Shivenarain Gupta
<p><strong>Introduction: </strong>The effect of Ayurvedic therapy in type 2 diabetes (T2D) is well documented. For people with type 1 diabetes (T1D), there is little evidence on the applicability of Ayurvedic therapy. This case illustrates the course of Ayurvedic treatment in a person with T1D accompanied by peripheral arterial occlusive disease (PAOD).</p><p><strong>Case presentation: </strong>The patient had insulin-dependent T1D since the age of 6 years. At 39 years of age, he developed progressive bilateral PAOD of the femoral arteries. He presented claudication symptoms at a walking distance of 150 m. Ten surgical interventions for recanalization have been performed. The PAOD put heavy psychological strains on the patient. He developed moderate depression with anxiety and complained of tinnitus and sleep disturbances. Through an initial outpatient Ayurvedic treatment mainly focused on dietary, lifestyle changes and phytotherapeutics, and a subsequent 6-week inpatient Ayurvedic treatment in India, a weight reduction of 12 kg, a reduction in insulin requirement to 65% of baseline, as well as a walking performance without restriction at a medium load could be achieved. The depression and inner tension retreated, and one-sided tinnitus and existing sleep disturbances dissolved completely. The lasting effect was still perceptible 5 months after the inpatient stay.</p><p><strong>Conclusions: </strong>For this person with T1D with PAOD, outpatient and inpatient Ayurvedic therapy could generate a significant improvement of his situation. The case demonstrates that people with T1D can benefit from using individualized Ayurvedic therapy. This case motivates to invest in Ayurvedic research for people with T1D and complications.</p><p><p><title>Einleitung</title>Die Wirkung der ayurvedischen Therapie bei Typ-2-Diabetes (T2D) ist gut dokumentiert. Für Menschen mit Typ-1-Diabetes (T1D) gibt es kaum Belege für die Anwendbarkeit der ayurvedischen Therapie. Dieser Fall veranschaulicht den Verlauf einer ayurvedischen Behandlung bei einer Person mit T1D, begleitet von einer peripheren arteriellen Verschlusskrankheit (pAVK).<title>Fallbericht</title>Der Patient hatte seit seinem 6. Lebensjahr einen insulinabhängigen 'T1D'. Im Alter von 39 Jahren entwickelte er eine fortschreitende bilaterale periphere arterielle Verschlusskrankheit (pAVK) der Oberschenkelarterien. Bei einer Gehstrecke von 150 m zeigte er Claudicatio-Symptome. Es wurden 10 chirurgische Eingriffe zur Rekanalisation durchgeführt. Die pAVK stellte für den Patienten eine starke psychische Belastung dar. Er entwickelte eine mittelschwere Depression mit Angstzuständen und klagte über Tinnitus und Schlafstörungen. Durch eine erste ambulante ayurvedische Behandlung, die sich hauptsächlich auf Ernährungs-, Lebensstiländerungen und Phytotherapeutika konzentrierte, und eine anschließende 6-wöchige stationäre ayurvedische Behandlung in Indien wurde eine Gewichtsreduktion um 12 kg, eine Reduzierung des Insul
引言:阿育吠陀治疗2型糖尿病(t2d)的效果有充分的文献记载。对于1型糖尿病(t1d)患者,几乎没有证据表明阿育吠陀疗法的适用性。该病例说明了一名t1d伴外周动脉闭塞性疾病(PAOD)患者的阿育吠陀治疗过程。病例介绍:该患者自6岁起就患有胰岛素依赖性t1d。39岁时,他患上了进行性双侧股动脉外周动脉闭塞性疾病(PAOD)。他在步行150米时出现跛行症状。已经进行了10次再通手术干预。PAOD给病人带来了沉重的心理压力。他出现了中度抑郁和焦虑,并抱怨耳鸣和睡眠障碍。通过最初的门诊阿育吠陀治疗,重点是饮食和生活方式的改变,植物疗法,以及随后在印度进行的为期6周的住院阿育吠吠陀治疗可以减轻12公斤的体重,将胰岛素需求降低到基线的65%,以及在中等负荷下无限制的行走性能。抑郁和内心紧张完全消退,单侧耳鸣,现有的睡眠障碍完全消失。住院5个月后,仍能感觉到持续的效果。结论:对于患有PAOD的t1d患者,门诊和住院阿育吠陀治疗可以显著改善他的情况。该案例表明,t1d患者可以从个性化的阿育吠陀治疗中受益。这个案例促使人们投资于针对t1d和并发症患者的阿育吠陀研究。
{"title":"Ayurveda for a Type 1 Diabetes Patient with Peripheral Arterial Occlusive Disease: A Case Report.","authors":"Elmar Stapelfeldt, Bettina Berger, Christa K Raak, Shivenarain Gupta","doi":"10.1159/000534992","DOIUrl":"10.1159/000534992","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The effect of Ayurvedic therapy in type 2 diabetes (T2D) is well documented. For people with type 1 diabetes (T1D), there is little evidence on the applicability of Ayurvedic therapy. This case illustrates the course of Ayurvedic treatment in a person with T1D accompanied by peripheral arterial occlusive disease (PAOD).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Case presentation: &lt;/strong&gt;The patient had insulin-dependent T1D since the age of 6 years. At 39 years of age, he developed progressive bilateral PAOD of the femoral arteries. He presented claudication symptoms at a walking distance of 150 m. Ten surgical interventions for recanalization have been performed. The PAOD put heavy psychological strains on the patient. He developed moderate depression with anxiety and complained of tinnitus and sleep disturbances. Through an initial outpatient Ayurvedic treatment mainly focused on dietary, lifestyle changes and phytotherapeutics, and a subsequent 6-week inpatient Ayurvedic treatment in India, a weight reduction of 12 kg, a reduction in insulin requirement to 65% of baseline, as well as a walking performance without restriction at a medium load could be achieved. The depression and inner tension retreated, and one-sided tinnitus and existing sleep disturbances dissolved completely. The lasting effect was still perceptible 5 months after the inpatient stay.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;For this person with T1D with PAOD, outpatient and inpatient Ayurvedic therapy could generate a significant improvement of his situation. The case demonstrates that people with T1D can benefit from using individualized Ayurvedic therapy. This case motivates to invest in Ayurvedic research for people with T1D and complications.&lt;/p&gt;&lt;p&gt;&lt;p&gt;&lt;title&gt;Einleitung&lt;/title&gt;Die Wirkung der ayurvedischen Therapie bei Typ-2-Diabetes (T2D) ist gut dokumentiert. Für Menschen mit Typ-1-Diabetes (T1D) gibt es kaum Belege für die Anwendbarkeit der ayurvedischen Therapie. Dieser Fall veranschaulicht den Verlauf einer ayurvedischen Behandlung bei einer Person mit T1D, begleitet von einer peripheren arteriellen Verschlusskrankheit (pAVK).&lt;title&gt;Fallbericht&lt;/title&gt;Der Patient hatte seit seinem 6. Lebensjahr einen insulinabhängigen 'T1D'. Im Alter von 39 Jahren entwickelte er eine fortschreitende bilaterale periphere arterielle Verschlusskrankheit (pAVK) der Oberschenkelarterien. Bei einer Gehstrecke von 150 m zeigte er Claudicatio-Symptome. Es wurden 10 chirurgische Eingriffe zur Rekanalisation durchgeführt. Die pAVK stellte für den Patienten eine starke psychische Belastung dar. Er entwickelte eine mittelschwere Depression mit Angstzuständen und klagte über Tinnitus und Schlafstörungen. Durch eine erste ambulante ayurvedische Behandlung, die sich hauptsächlich auf Ernährungs-, Lebensstiländerungen und Phytotherapeutika konzentrierte, und eine anschließende 6-wöchige stationäre ayurvedische Behandlung in Indien wurde eine Gewichtsreduktion um 12 kg, eine Reduzierung des Insul","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"94-102"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72013778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Individualized Homeopathic Medicines in the Treatment of Post-COVID-19 Fatigue in Adults: Single-Blind, Randomized, Placebo-Controlled Trial. 个体化顺势疗法药物治疗成人covid -19后疲劳:一项单盲、随机、安慰剂对照试验
IF 1.8 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-01-01 Epub Date: 2023-11-26 DOI: 10.1159/000535279
Sangita Saha, Rakesh Singh, Ishika Mani, Kalyan Chakraborty, Paulami Sarkar, Subhranil Saha, Abhijit Rana, Rajat Chattopadhyay
<p><strong>Introduction: </strong>The coronavirus disease 2019 (COVID-19) is leading to unknown and unusual health conditions that are challenging to manage. Post-COVID-19 fatigue is one of those challenges, becoming increasingly common as the pandemic evolves, as it impairs the quality of life of an individual. This trial attempts to identify the preliminary evidence of the efficacy of individualized homeopathic medicines (IHMs) against placebos in the treatment of post-COVID-19 fatigue in adults.</p><p><strong>Methods: </strong>A 3-month, single-blind, randomized, placebo-controlled, parallel-arm trial was conducted at the outpatient department of The Calcutta Homoeopathic Medical College and Hospital, India. Sixty participants were randomized in a 1:1 ratio to receive either IHMs (n = 30) or identical-looking placebos (n = 30). The primary and secondary outcome measures were the Fatigue Assessment Scale (FAS) and Outcome in Relation to Impact on Daily Living (ORIDL), respectively, measured every month, for up to 3 months. Comparative analysis was carried out on the intention-to-treat sample to detect group differences.</p><p><strong>Results: </strong>Group differences in both the primary (FAS total: F1, 58 = 14.356, p < 0.001) and secondary outcomes (ORIDL: F1, 58 = 210.986, p < 0.001) after 3 months favored IHMs against placebos. Lycopodium clavatum (11.7%), sulfur (11.7%), Arsenicum album (10%), and Thuja occidentalis (10%) were the most frequently indicated medicines. No harm, unintended effects, homeopathic aggravations, or any serious adverse events were reported from either of the groups.</p><p><strong>Conclusion: </strong>IHMs produced significantly better effects than placebos in the treatment of post-COVID-19 fatigue in adults. Definitive robust trials may be undertaken to confirm the findings.</p><p><p><title>Einleitung</title>Die Coronainfektion (COVID-19) zieht unbekannte und ungewöhnliche gesundheitliche Probleme nach sich, deren Management oft eine Herausforderung darstellt. Das gilt unter anderem für Ermüdung nach einer COVID-19-Erkrankung, die mit zunehmender Dauer der Pandemie immer häufiger auftritt und die Lebensqualität der Betroffenen beeinträchtigt. In dieser Studie wird versucht, vorläufige Belege für die Wirksamkeit individualisierter homöopathischer Mittel (IHM) im Vergleich zu Placebo zur Behandlung von Ermüdung nach COVID-19 bei Erwachsenen zu identifizieren.<title>Methoden</title>Eine einfach verblindete, randomisierte, placebokontrollierte Parallelgruppenstudie von 3 Monaten Dauer wurde im ambulanten Bereich des Calcutta Homoeopathic Medical College and Hospital in Indien durchgeführt. 60 Teilnehmer erhielten nach Randomisierung im Verhältnis 1:1 entweder IHM (<italic>n</italic> = 30) oder identisch aussehendes Placebo (<italic>n</italic> = 30). Die primäre und die sekundäre Zielgröße waren die Fatigue Assessment Scale (FAS) und das Outcome in Relation to Impact on Daily Living (ORIDL) für bis zu 3 Monate, je
新型冠状病毒病(COVID-19)正在导致未知和不寻常的健康状况,这些状况极具挑战性。covid -19后疲劳就是其中一项挑战,随着疫情的发展,这种挑战变得越来越普遍,因为它会损害个人的生活质量。本试验试图确定个体化顺势疗法药物(IHMs)在治疗成人covid -19后疲劳方面优于安慰剂的初步证据。方法:在印度加尔各答顺势疗法医学院门诊部进行了一项为期3个月的单盲、随机、安慰剂对照、平行对照试验。60名参与者以1:1的比例随机分配,接受ihm (n = 30)或相同外观的安慰剂(n = 30)。主要和次要结果测量分别是疲劳评估量表(FAS)和与日常生活影响相关的结果(ORIDL),每个月测量一次,持续3个月。对意向治疗样本进行对比分析,检测组间差异。结果:3个月后的主要结局(FAS total: F1, 58 = 14.356, P < 0.001)和次要结局(ORIDL: F1, 58 = 210.986, P < 0.001)的组间差异均有利于ihm组优于安慰剂组。最常使用的药物为石蒜(11.7%)、硫(11.7%)、砷(10%)和西花(10%)。两组均未报告任何伤害、意外效应、顺势疗法加重或任何严重不良事件。结论:IHMs治疗成人covid -19后疲劳的效果明显优于安慰剂。可以进行明确、有力的试验来证实这些发现。试验报名:CTRI/2022/03/041316。
{"title":"Individualized Homeopathic Medicines in the Treatment of Post-COVID-19 Fatigue in Adults: Single-Blind, Randomized, Placebo-Controlled Trial.","authors":"Sangita Saha, Rakesh Singh, Ishika Mani, Kalyan Chakraborty, Paulami Sarkar, Subhranil Saha, Abhijit Rana, Rajat Chattopadhyay","doi":"10.1159/000535279","DOIUrl":"10.1159/000535279","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The coronavirus disease 2019 (COVID-19) is leading to unknown and unusual health conditions that are challenging to manage. Post-COVID-19 fatigue is one of those challenges, becoming increasingly common as the pandemic evolves, as it impairs the quality of life of an individual. This trial attempts to identify the preliminary evidence of the efficacy of individualized homeopathic medicines (IHMs) against placebos in the treatment of post-COVID-19 fatigue in adults.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A 3-month, single-blind, randomized, placebo-controlled, parallel-arm trial was conducted at the outpatient department of The Calcutta Homoeopathic Medical College and Hospital, India. Sixty participants were randomized in a 1:1 ratio to receive either IHMs (n = 30) or identical-looking placebos (n = 30). The primary and secondary outcome measures were the Fatigue Assessment Scale (FAS) and Outcome in Relation to Impact on Daily Living (ORIDL), respectively, measured every month, for up to 3 months. Comparative analysis was carried out on the intention-to-treat sample to detect group differences.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Group differences in both the primary (FAS total: F1, 58 = 14.356, p &lt; 0.001) and secondary outcomes (ORIDL: F1, 58 = 210.986, p &lt; 0.001) after 3 months favored IHMs against placebos. Lycopodium clavatum (11.7%), sulfur (11.7%), Arsenicum album (10%), and Thuja occidentalis (10%) were the most frequently indicated medicines. No harm, unintended effects, homeopathic aggravations, or any serious adverse events were reported from either of the groups.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;IHMs produced significantly better effects than placebos in the treatment of post-COVID-19 fatigue in adults. Definitive robust trials may be undertaken to confirm the findings.&lt;/p&gt;&lt;p&gt;&lt;p&gt;&lt;title&gt;Einleitung&lt;/title&gt;Die Coronainfektion (COVID-19) zieht unbekannte und ungewöhnliche gesundheitliche Probleme nach sich, deren Management oft eine Herausforderung darstellt. Das gilt unter anderem für Ermüdung nach einer COVID-19-Erkrankung, die mit zunehmender Dauer der Pandemie immer häufiger auftritt und die Lebensqualität der Betroffenen beeinträchtigt. In dieser Studie wird versucht, vorläufige Belege für die Wirksamkeit individualisierter homöopathischer Mittel (IHM) im Vergleich zu Placebo zur Behandlung von Ermüdung nach COVID-19 bei Erwachsenen zu identifizieren.&lt;title&gt;Methoden&lt;/title&gt;Eine einfach verblindete, randomisierte, placebokontrollierte Parallelgruppenstudie von 3 Monaten Dauer wurde im ambulanten Bereich des Calcutta Homoeopathic Medical College and Hospital in Indien durchgeführt. 60 Teilnehmer erhielten nach Randomisierung im Verhältnis 1:1 entweder IHM (&lt;italic&gt;n&lt;/italic&gt; = 30) oder identisch aussehendes Placebo (&lt;italic&gt;n&lt;/italic&gt; = 30). Die primäre und die sekundäre Zielgröße waren die Fatigue Assessment Scale (FAS) und das Outcome in Relation to Impact on Daily Living (ORIDL) für bis zu 3 Monate, je","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138440346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum. 勘误。
IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-01-01 Epub Date: 2024-07-19 DOI: 10.1159/000540335
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引用次数: 0
Viscum Album Lipophilic Extract in Actinic Keratosis, Cutaneous Squamous Cell Carcinoma, and Basal Cell Carcinoma: A Retrospective Case Series. 肤黏液提取物在皮肤角化病、皮肤鳞状细胞癌和基底细胞癌中的应用:回顾性病例系列。
IF 1.8 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.1159/000537979
Karolina Königsberger, Konrad Urech, Marcus Reif, Stephan Baumgartner, David Martin, Wilfried Tröger
<p><strong>Introduction: </strong>Cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma (BCC) belong to the group of keratinocyte carcinomas (KC). Actinic keratosis (AK) is a precursor lesion of cSCC. The incidences of cSCC, BCC, and AK are currently strongly increasing. Different standard therapies exist for these conditions but are not always applicable or successful. Hydrophilic Viscum album extracts have been used in anthroposophic cancer therapy since 1917. Viscum album lipophilic extract (VALE) is prepared by means of supercritical CO2 extraction. This retrospective case series assessed the safety and clinical effects of a topical application of 10% VALE in individual cases of cSCC, BCC, and AK.</p><p><strong>Methods: </strong>For this retrospective case series, a positive vote was obtained from the Ethics Committee of the University of Witten/Herdecke (No. 146/2020). Eligible patients signed a declaration of consent prior to inclusion in the study. The main outcome parameters were the clinical response to treatment with VALE and adverse drug reactions. Risk factors, concomitant therapies and diseases, further diagnostic and therapeutic information were documented where available. Data analysis was performed on the level of patients and of individual lesions.</p><p><strong>Results: </strong>The study population consisted of 55 patients with 74 skin lesions. Individual case analysis accompanied by photographic documentation revealed typical and promising treatment courses. Clinical response rates (complete + partial remissions) for individual lesions were 78% for cSCC, 70% for BCC, and 71% for AK. Complete remission rates for individual lesions were 56% for cSCC, 35% for BCC, and 15% for AK. In cSCC and BCC, shorter times to best clinical response were observed. Adverse drug reactions were reported in 5 patients including erythema and inflammatory reactions of mostly moderate severity that resolved completely. In one case, therapy was temporarily paused, in four cases it was continued without interruption.</p><p><strong>Discussion/conclusion: </strong>The results of this study suggest that VALE is a safe and tolerable extract under whose application complete and partial remissions of KC could be observed. To improve and assess the efficacy of VALE, prospective investigations are necessary.</p><p><p><title>Einleitung</title>Das kutane Plattenepithelkarzinom (cSCC) und das Basalzellkarzinom (BCC) gehören zur Gruppe der Keratinozytenkarzinome (KC). Die aktinische Keratose (AK) ist eine Vorstufe des cSCC. Die Häufigkeit von cSCC, BCC und AK ist derzeit stark im Steigen begriffen. Es gibt verschiedene Standardtherapien für diese Erkrankungen, die jedoch nicht immer anwendbar oder erfolgreich sind. Hydrophile <italic>Viscum album</italic>-Extrakte werden seit 1917 in der anthroposophischen Krebstherapie eingesetzt. <italic>Viscum album</italic> Lipophilic Extract (VALE) wird mittels überkritischer CO2-Extraktion hergestellt. In dieser
导言 皮肤鳞状细胞癌(cSCC)和基底细胞癌(BCC)属于角质细胞癌(KC)。日光性角化病(AK)是 cSCC 的前驱病变。目前,cSCC、BCC 和 AK 的发病率正急剧上升。针对这些病症有不同的标准疗法,但并不总是适用或成功的。自 1917 年以来,亲水性粘液提取物一直被用于人类癌症疗法。粘液亲水提取物(VALE)是通过超临界二氧化碳萃取法制备的。本回顾性病例系列评估了局部使用 10% VALE 治疗 cSCC、BCC 和 AK 的安全性和临床效果。方法 本回顾性病例系列获得了威滕/赫德克大学伦理委员会的赞成票(第 146/2020 号)。符合条件的患者在加入研究前签署了同意声明。主要结果参数为对 VALE 治疗的临床反应和药物不良反应。如有风险因素、伴随治疗和疾病、其他诊断和治疗信息,则记录在案。数据分析以患者和单个病灶为单位进行。结果 研究对象包括 55 名患者,74 处皮损。通过对单个病例进行分析,并辅以照片资料,发现了典型且有希望的治疗过程。单个皮损的临床反应率(完全缓解+部分缓解)分别为:cSCC 78%、BCC 70%、AK 71%。单个病灶的完全缓解率为:cSCC 56%、BCC 35%、AK 15%。在 cSCC 和 BCC 中,观察到的最佳临床反应时间较短。据报道,有五名患者出现了药物不良反应,包括红斑和炎症反应,大多为中度,但已完全缓解。有 1 例患者暂时中止了治疗,有 4 例患者继续治疗,没有中断。讨论/结论 本研究结果表明,VALE 是一种安全、可耐受的提取物,应用后可观察到 KC 完全或部分缓解。为了提高和评估 VALE 的疗效,有必要进行前瞻性研究。
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Complementary Medicine Research
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