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Obituary - Torkel Falkenberg. 讣告 - Torkel Falkenberg.
IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-08-13 DOI: 10.1159/000540742
Harald Walach
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引用次数: 0
Effect of Long-Snake Moxibustion on Gut Microbiota of Patients with Ankylosing Spondylitis. 长蛇灸对强直性脊柱炎患者肠道微生物群的影响
IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-08-09 DOI: 10.1159/000540271
Xijing Yu, Mengyu Jin, Hui Huang, Fenfen Qiu, Lele Geng, Rong Guo, Xiaoyan Zhu, Xiuwu Hu

Objective: The objectively was to study the effect of long-snake moxibustion intervention on gut microbiota of patients with ankylosing spondylitis (AS) by 16S rDNA sequencing technology.

Methods: Thirty AS patients and 30 healthy volunteers were recruited and treated with long-snake moxibustion once a week for 12 weeks. AS patients were divided into pretreatment and posttreatment groups. VAS, BASDAI, and BASFI scores of AS patients before and after treatment were collected. 16S rDNA high-throughput sequencing technology was used to analyze the characteristics and differences of gut microbiota in AS patients before and after treatment and in healthy volunteers.

Results: VAS, BASDAI, and BASFI scores of AS patients after long-snake moxibustion treatment were lower than those of pretreatment group (p < 0.05). The results of gut microbiota alpha diversity showed that Ace and Chao1 index of the posttreatment group were higher than those of the health group (p < 0.05), but there was no statistical significance in Ace and Chao1 index between the pretreatment group and the posttreatment group (p > 0.05). Beta diversity analysis showed that mild classification aggregation occurred between the health group and the pretreatment group but did not reach a significant level, and there was no significant difference between the pretreatment group and the posttreatment group. The results of species abundance showed that, at the phylum level, compared with the health group, the relative abundance of Firmicutes and Proteobacteria decreased in the pretreatment group, while the relative abundance of Bacteroidetes and Actinobacteria increased. Compared with the pretreatment group, the relative abundance of Firmicutes increased and the relative abundance of Actinobacteria decreased in the posttreatment group, but there were no statistically significant differences in the above changes (p > 0.05). At the genus level, compared with the health group, the relative abundances of Subdoligranulum in the pretreatment group were increased (p < 0.05), while the relative abundances of Bifidobacterium and Streptococcus were decreased (p < 0.05). Compared with the pretreatment group, the relative abundance of Romboutsia in the posttreatment group was increased (p < 0.05).

Conclusion: Long-snake moxibustion can obviously improve the clinical symptoms of AS patients. The possible mechanism of action is related to regulating the abundance of gut microbiota, increasing beneficial bacteria, and restoring the homeostasis of gut microorganisms.

目的方法:招募30名强直性脊柱炎(AS)患者和30名健康志愿者,对其进行长蛇灸治疗,每周一次,连续12周。将 AS 患者分为治疗前和治疗后两组。收集治疗前后 AS 患者的 VAS、BASDAI 和 BASFI 评分。采用16S rDNA高通量测序技术分析了治疗前后强直性脊柱炎患者和健康志愿者肠道微生物群的特征和差异:结果:长蛇灸治疗后强直性脊柱炎患者的VAS、BASDAI和BASFI评分均低于治疗前(P<0.05)。肠道微生物群Alpha多样性结果显示,治疗后组的ace和chao1指数高于健康组(P<0.05),但治疗前组与治疗后组的ace和chao1指数差异无统计学意义(P>0.05)。Beta 多样性分析表明,健康组与处理前组之间存在轻度分类聚集,但未达到显著水平,处理前组与处理后组之间无显著差异。物种丰度结果表明,与健康组相比,在门的层次上,处理前组的固着菌和变形菌相对丰度下降,而类杆菌和放线菌相对丰度上升。与治疗前相比,治疗后组的固缩菌相对丰度增加,放线菌相对丰度减少,但上述变化差异无统计学意义(P>0.05)。在菌属水平上,与健康组相比,治疗前组 Subdoligranulum 的相对丰度升高(P<0.05),而双歧杆菌和链球菌的相对丰度降低(P<0.05)。与治疗前相比,治疗后组的隆突菌相对丰度增加(P<0.05):结论:长蛇灸能明显改善强直性脊柱炎患者的临床症状。结论:长蛇灸能明显改善强直性脊柱炎患者的临床症状,其作用机制可能与调节肠道微生物群的丰度、增加有益菌、恢复肠道微生物的平衡有关。
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引用次数: 0
What a Study Is about Should Be Clear. 研究的目的应该是明确的。
IF 1.1 4区 医学 Q2 Medicine Pub Date : 2024-06-10 DOI: 10.1159/000539409
Axel Wiebrecht
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引用次数: 0
The Use of Music-based Interventions in Persian Medicine. 在波斯医学中使用音乐干预。
IF 1.8 4区 医学 Q2 Medicine Pub Date : 2024-04-22 DOI: 10.1159/000538920
Majid Dadmeher, Elham Akhtari, Mohammad Sadr, M. Haqiqi
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引用次数: 0
Development of the Blood Stasis Questionnaire for gynecological diseases: an analytical cross-sectional study. 妇科疾病血瘀调查问卷的开发:一项横断面分析研究。
IF 1.8 4区 医学 Q2 Medicine Pub Date : 2024-04-17 DOI: 10.1159/000538568
Byoung-Kab Kang, Soobin Jang, Mi Mi Ko, Jeeyoun Jung
OBJECTIVESBlood stasis is the slowing or stagnation of blood and can cause metabolic, musculoskeletal, and gynecological diseases. This study developed the Blood Stasis Questionnaire for gynecological disease (BSQ-GD) by extracting clinical indicators related to gynecological diseases using the Blood Stasis Questionnaires I and II (BSQ-I and II, respectively) and analyzed the clinical data of a cross-sectional study.PATIENTS AND METHODSIn total, 103 women aged between 25-65 years who met gynecological disease criteria were enrolled in this study. Blood stasis scores (BSS) were evaluated using the BSQ-II and categorized into BSS and non-BSS groups.To assess the reliability of BSQ-GD, the internal consistency coefficient was employed using Cronbach's α. Furthermore, correlation analyses were conducted for the clinical symtoms related to gynecological diseases and and the discriminant validity was confirmed by comparing the two groups. The prediction accuracy was determined using logistic regression and the cut-off value of the BSQ-GD was established via the sensitivity and specificity cacluations.RESULTSThe BSQ-GD showed satisfactory internal consistency (Cronbach's α coefficient = 0.71) and validity, with significant differences in mean scores between blood stasis (22.30±3.34) and non-blood stasis (14.93±3.49) groups. The cut-off value of the BSQ-GD score was 19 points when the Youden index (73.45) and the concordance probability (0.75) were at their maximum. The area under the receiver operating characteristic curve was approximately 96%, and the sensitivity and specificity of the diagnostic accuracy according to the cut-off value are 80.95% and 92.50%, respectively.CONCLUSIONThe BSQ-GD can be an appropriate instrument to estimate blood stasis in patients with gynecological diseases; its diagnostic sensitivity according to the cut-off value is high.
目的 血瘀是指血液运行缓慢或停滞,可引起代谢性疾病、肌肉骨骼疾病和妇科疾病。本研究通过使用血瘀问卷 I 和 II(分别为 BSQ-I 和 II)提取与妇科疾病相关的临床指标,并分析横断面研究的临床数据,编制了妇科疾病血瘀问卷(BSQ-GD)。使用 BSQ-II 评估血瘀评分(BSS),并将其分为 BSS 组和非 BSS 组。为了评估 BSQ-GD 的可靠性,使用 Cronbach's α 计算内部一致性系数。此外,还对与妇科疾病相关的临床症状进行了相关性分析,并通过比较两组的临床症状确认了其区分效度。结果BSQ-GD显示出令人满意的内部一致性(Cronbach's α系数=0.71)和有效性,血瘀组(22.30±3.34)和非血瘀组(14.93±3.49)的平均得分差异显著。当尤登指数(73.45)和一致性概率(0.75)达到最大值时,BSQ-GD 评分的临界值为 19 分。结论 BSQ-GD 可作为估测妇科疾病患者血瘀程度的合适工具;根据临界值,其诊断灵敏度较高。
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引用次数: 0
Validierung eines Fragebogeninstrumentes zur Erfassung des Erlebens von Natur: Die Experience of Nature Scale. 验证记录自然体验的问卷工具:自然体验量表。
IF 1.8 4区 医学 Q2 Medicine Pub Date : 2024-04-17 DOI: 10.1159/000538807
Arndt Büssing, D. R. Recchia, M. Ortiz
Hintergrund: In den letzten Jahren ist insbesondere die Natur als Ressource in das Interesse der gesundheitspsychologischen Forschung gerückt. In Ergänzung zum etablierten Konzept der Naturzuwendung als Haltung wurde ein Forschungsinstrument zum Naturerleben entwickelt, welches das subjektive, teilweise intentionale Erleben von Natur unter unterschiedlichen Aspekten beleuchtet. Dazu gehören insbesondere Natur als Erlebensraum, um sich von der Alltagsbelastung distanzieren zu können, um Auszeit durch Ruhe und Stille finden zu können, um emotionale Ausgeglichenheit zu erlangen, Natur als Ort der Faszination und des Staunens, Naturerleben als Basis für einen verantwortlichen Umgang mit der Natur. Das Manuskript zeigt die Ergebnisse der Validierung des neu entwickelte Fragebogeninstrument zum Naturerleben. Methoden: Anonyme Online-Querschnittsstudie unter 441 Teilnehmenden mit standardisierten Fragebogeninstrumenten zur Validierung der Experience of Nature Scale (ENS) mittels explorativer Faktoren- (Hauptkomponentenanalyse mit Varimax-Rotation) und Reliabilitätsanalysen (Cronbachs alpha). Ergebnisse: Die explorative Faktorenanalyse der Naturerlebens-Skala mit 11 Items ergab drei Hauptfaktoren mit guter interner Kongruenz, die 71% der Varianz erklären: 1) Alltagsdistanzierung/Entspannung (Cronbachs α = 0,87), 2) Faszination Natur/Staunen (Cronbachs α = 0,82) und 3) Verantwortungsempfinden für Natur (Cronbachs α = 0,85) Diese Faktoren korrelierten stark mit der Naturverbundenheit (NR-6) und moderat bis stark mit Ehrfurcht/Dankbarkeit (GrAw-7) im Sinne der Konvergenzvalidität, aber nur marginal bis schwach mit psychologischem Wohlbefinden (WHO-5). Schlussfolgerungen: Die Experience of Nature Scale zur Erfassung des affektiven Erlebens von Natur hat gute psychometrische Qualitätsindizes und kann in künftigen Studien zur Bedeutung dieses Erlebens von Natur zum Beispiel als Prädiktor- oder Prozessvariable eingesetzt werden.
背景:近年来,自然作为一种资源已成为健康心理学研究的一个特别关注点。除了作为一种态度的 "欣赏自然 "这一既定概念外,还开发了一种关于自然体验的研究工具,从多个方面研究对自然的主观、部分有意的体验。这些方面尤其包括:自然是一个体验空间,在其中可以远离日常生活的压力,在宁静中寻找时间,实现情感平衡;自然是一个令人着迷和惊奇的地方;自然体验是对自然采取负责任态度的基础。手稿展示了新开发的自然体验问卷工具的验证结果。研究方法对 441 名参与者进行匿名在线横断面研究,使用标准化的问卷工具,通过探索性因子分析(主成分分析与 Varimax 旋转)和可靠性分析(Cronbach's alpha)对自然体验量表(ENS)进行验证。结果:通过对自然体验量表的 11 个项目进行探索性因子分析,发现了三个具有良好内部一致性的主因子,它们解释了 71% 的方差:这些因子与亲近自然(NR-6)和敬畏/感恩(GrAw-7)的相关性较强,但与心理健康(WHO-5)的相关性较弱。结论记录自然情感体验的自然体验量表具有良好的心理测量质量指标,可用于未来有关自然体验重要性的研究,例如作为预测变量或过程变量。
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引用次数: 0
An acupuncture protocol for the treatment of erectile dysfunction (ED) - a Delphi-process. 针灸治疗勃起功能障碍(ED)方案--德尔菲过程。
IF 1.8 4区 医学 Q2 Medicine Pub Date : 2024-04-17 DOI: 10.1159/000538750
Merete Lindén Dahle, T. Alræk, Frauke Musial
INTRODUCTIONErectile Dysfunction (ED) is a widespread disorder, and the worldwide incidence is rapidly increasing. Acupuncture, an intervention out of the spectrum of Traditional Chinese Medicine (TCM) has a long tradition as treatment for ED. Nonetheless, a best practice treatment protocol is currently missing. A recent systematic review and meta-analysis confirmed a huge diversity of acupuncture treatments for ED and concluded that there is an urgent need to standardize acupuncture treatment for ED. Consequently, the authors conducted a Delphi process with the aim to achieve an expert consensus as a basis for the development of a best practice protocol.METHODSThe Delphi process consisted of four rounds of questionnaires with closed and open-ended questions. Eleven acupuncture experts participated. The therapeutic aim was defined as "to achieve an erection sufficient for sexual satisfaction".RESULTSConsensus was achieved on 24 acupoints corresponding to 12 TCM syndromes. The syndromes were KI Yang xu, KI Yin xu, KI Qi xu, Ki and HT not harmonised, LR Qi Stagnation, LR Qi stagnation and Heat, Liver Blood xu, Liver Blood xu and Liver Qi stagnation, Damp-heat sinking to the lower Jiao5, HT and GB Qi xu, SP xu and HT Blood xu, Yin xu. The suggested optimal dose was between11-15 treatments given once or twice a week.CONCLUSIONAn expert consensus-based, semi-standardized best practice treatment protocol for the treatment of ED was developed. Moreover, the Delphi process also revealed inconsistencies as to which signs and symptoms constitute a TCM syndrome. Further Delphi studies including a broader range of experts from various acupuncture traditions are needed to establish further agreement. Nonetheless, the best practice protocol introduced in this paper provides a first point of departure for the implementation of a more standardized treatment approach. Moreover, since a recent meta-analysis concluded that more high-quality clinical studies on the topic are needed, this paper provides a first standardized acupuncture treatment protocol for ED.
简介:勃起功能障碍(ED)是一种普遍存在的疾病,其发病率在全球范围内迅速上升。针灸作为传统中医(TCM)的一种干预手段,在治疗勃起功能障碍方面有着悠久的传统。然而,目前尚无最佳治疗方案。最近的一项系统综述和荟萃分析证实,针灸治疗 ED 的方法多种多样,并得出结论:迫切需要规范针灸治疗 ED 的方法。因此,作者开展了德尔菲进程,旨在达成专家共识,为制定最佳实践方案奠定基础。11 位针灸专家参与了这一过程。治疗目的被定义为 "使阴茎勃起达到性满足"。这些证候包括:祺阳虚、祺阴虚、祺气虚、祺与 HT 不协调、LR 气滞、LR 气滞热、肝血虚、肝血虚与肝气郁结、湿热下注下焦5、HT 与 GB 气虚、SP 虚与 HT 血虚、阴虚。建议的最佳剂量为 11-15 个疗程,每周 1-2 次。此外,德尔菲法还揭示了哪些体征和症状构成中医综合征的不一致之处。要进一步达成一致意见,还需要更多来自不同针灸传统的专家参与德尔菲研究。尽管如此,本文介绍的最佳实践方案为实施更加标准化的治疗方法提供了第一个出发点。此外,由于最近的一项荟萃分析得出结论认为需要对该主题进行更多高质量的临床研究,因此本文提供了首个针对 ED 的标准化针灸治疗方案。
{"title":"An acupuncture protocol for the treatment of erectile dysfunction (ED) - a Delphi-process.","authors":"Merete Lindén Dahle, T. Alræk, Frauke Musial","doi":"10.1159/000538750","DOIUrl":"https://doi.org/10.1159/000538750","url":null,"abstract":"INTRODUCTION\u0000Erectile Dysfunction (ED) is a widespread disorder, and the worldwide incidence is rapidly increasing. Acupuncture, an intervention out of the spectrum of Traditional Chinese Medicine (TCM) has a long tradition as treatment for ED. Nonetheless, a best practice treatment protocol is currently missing. A recent systematic review and meta-analysis confirmed a huge diversity of acupuncture treatments for ED and concluded that there is an urgent need to standardize acupuncture treatment for ED. Consequently, the authors conducted a Delphi process with the aim to achieve an expert consensus as a basis for the development of a best practice protocol.\u0000\u0000\u0000METHODS\u0000The Delphi process consisted of four rounds of questionnaires with closed and open-ended questions. Eleven acupuncture experts participated. The therapeutic aim was defined as \"to achieve an erection sufficient for sexual satisfaction\".\u0000\u0000\u0000RESULTS\u0000Consensus was achieved on 24 acupoints corresponding to 12 TCM syndromes. The syndromes were KI Yang xu, KI Yin xu, KI Qi xu, Ki and HT not harmonised, LR Qi Stagnation, LR Qi stagnation and Heat, Liver Blood xu, Liver Blood xu and Liver Qi stagnation, Damp-heat sinking to the lower Jiao5, HT and GB Qi xu, SP xu and HT Blood xu, Yin xu. The suggested optimal dose was between11-15 treatments given once or twice a week.\u0000\u0000\u0000CONCLUSION\u0000An expert consensus-based, semi-standardized best practice treatment protocol for the treatment of ED was developed. Moreover, the Delphi process also revealed inconsistencies as to which signs and symptoms constitute a TCM syndrome. Further Delphi studies including a broader range of experts from various acupuncture traditions are needed to establish further agreement. Nonetheless, the best practice protocol introduced in this paper provides a first point of departure for the implementation of a more standardized treatment approach. Moreover, since a recent meta-analysis concluded that more high-quality clinical studies on the topic are needed, this paper provides a first standardized acupuncture treatment protocol for ED.","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140691701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How effective is drinking natural mineral water against heartburn from functional dyspepsia, gastroesophageal reflux disease or other causes? A systematic review of clinical intervention studies. 饮用天然矿泉水对功能性消化不良、胃食管反流病或其他原因引起的胃灼热有多大效果?临床干预研究的系统回顾。
IF 1.8 4区 医学 Q2 Medicine Pub Date : 2024-01-03 DOI: 10.37766/inplasy2024.1.0007
Arun D'Souza, K. Zink, Jost Langhorst, Manfred Wildner, C. Stupp, Thomas Keil
Background For centuries, spring and other natural waters have been recommended as external or internal remedies for numerous diseases. For studies that examined the effects of drinking mineral waters against heartburn, gastroesophageal reflux disease (GERD), or functional dyspepsia a systematic review is lacking. Objectives The main aim of this systematic review was to examine the effects of drinking natural mineral waters on heartburn from various causes by identifying all published intervention studies and critically appraising their methods as well as summarizing their results. Methods We systematically searched the largest medical literature database MEDLINE, further relevant web sources and gray literature for randomized and non-randomized trials, with or without control groups, up to September 2021 and no language restrictions. Further inclusion criteria were adult patients with heartburn, drinking cure with natural mineral water as intervention, compared to no or other interventions (care-as-usual, waiting list). We defined the reduction of heartburn symptoms and duration of disease episodes as primary and quality of life as secondary outcomes. Two reviewers independently carried out the study quality assessments (risk of bias) using the National Institutes of Health-Study Quality Assessment Tools. Results Nine trials comprising 393 patients from Italy, Russia, Ukraine, and Germany fulfilled all inclusion criteria. We identified three randomized controlled trials (all with poor methodological quality), plus six before-after (pre/post) intervention studies without a control group. The intervention groups of the three comparative trials seemed to show a stronger reduction of self-reported heartburn symptoms, and duration of heartburn episodes than the respective control groups, however they all had a poor methodological quality. Conclusion Based on the best available evidence of clinical studies, we cannot recommend or advise against drinking natural mineral waters as a treatment for heartburn. The potential benefits of natural mineral waters that were reported in some studies with a lower evidence level (e.g., lacking a control group) should be verified by good quality randomized clinical trials with adequate comparison groups and longer follow-up periods. .
背景几个世纪以来,人们一直建议将矿泉水和其他天然水作为治疗多种疾病的外用或内服疗法。关于饮用矿泉水对胃灼热、胃食管反流病(GERD)或功能性消化不良的影响,目前还缺乏系统性综述。目的 本系统综述的主要目的是通过识别所有已发表的干预研究,对其方法进行批判性评估并总结其结果,从而研究饮用天然矿泉水对各种原因引起的胃灼热的影响。方法 我们系统地检索了最大的医学文献数据库 MEDLINE、其他相关网络资源和灰色文献,以查找截至 2021 年 9 月的随机和非随机试验,无论是否有对照组,且无语言限制。进一步的纳入标准是患有胃灼热的成年患者,以饮用天然矿泉水作为干预措施,与不采取或其他干预措施(照常护理、等待名单)进行比较。我们将减少胃灼热症状和疾病发作持续时间定义为主要结果,将生活质量定义为次要结果。两名评审员使用美国国立卫生研究院的研究质量评估工具独立进行了研究质量评估(偏倚风险)。结果 来自意大利、俄罗斯、乌克兰和德国的九项试验(包括 393 名患者)符合所有纳入标准。我们确定了三项随机对照试验(方法质量均较差),以及六项无对照组的前后(前/后)干预研究。与对照组相比,三项比较试验的干预组似乎更能减轻自我报告的胃灼热症状,缩短胃灼热发作的持续时间,但它们的方法质量都很差。结论 根据现有的最佳临床研究证据,我们不能建议或反对饮用天然矿泉水来治疗胃灼热。一些证据水平较低的研究(如缺乏对照组)中报告的天然矿泉水的潜在益处,应通过质量良好的随机临床试验进行验证,这些试验应具有充分的对比组和较长的随访期。.
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引用次数: 0
Ayurveda for a Type 1 Diabetes Patient with Peripheral Arterial Occlusive Disease: A Case Report. 阿育吠陀治疗患有外周动脉闭塞性疾病(PAOD)的1型糖尿病患者。
IF 1.8 4区 医学 Q2 Medicine Pub Date : 2024-01-01 Epub Date: 2023-11-09 DOI: 10.1159/000534992
Elmar Stapelfeldt, Bettina Berger, Christa K Raak, Shivenarain Gupta

Introduction: The effect of Ayurvedic therapy in type 2 diabetes (T2D) is well documented. For people with type 1 diabetes (T1D), there is little evidence on the applicability of Ayurvedic therapy. This case illustrates the course of Ayurvedic treatment in a person with T1D accompanied by peripheral arterial occlusive disease (PAOD).

Case presentation: The patient had insulin-dependent T1D since the age of 6 years. At 39 years of age, he developed progressive bilateral PAOD of the femoral arteries. He presented claudication symptoms at a walking distance of 150 m. Ten surgical interventions for recanalization have been performed. The PAOD put heavy psychological strains on the patient. He developed moderate depression with anxiety and complained of tinnitus and sleep disturbances. Through an initial outpatient Ayurvedic treatment mainly focused on dietary, lifestyle changes and phytotherapeutics, and a subsequent 6-week inpatient Ayurvedic treatment in India, a weight reduction of 12 kg, a reduction in insulin requirement to 65% of baseline, as well as a walking performance without restriction at a medium load could be achieved. The depression and inner tension retreated, and one-sided tinnitus and existing sleep disturbances dissolved completely. The lasting effect was still perceptible 5 months after the inpatient stay.

Conclusions: For this person with T1D with PAOD, outpatient and inpatient Ayurvedic therapy could generate a significant improvement of his situation. The case demonstrates that people with T1D can benefit from using individualized Ayurvedic therapy. This case motivates to invest in Ayurvedic research for people with T1D and complications.

EinleitungDie Wirkung der ayurvedischen Therapie bei Typ-2-Diabetes (T2D) ist gut dokumentiert. Für Menschen mit Typ-1-Diabetes (T1D) gibt es kaum Belege für die Anwendbarkeit der ayurvedischen Therapie. Dieser Fall veranschaulicht den Verlauf einer ayurvedischen Behandlung bei einer Person mit T1D, begleitet von einer peripheren arteriellen Verschlusskrankheit (pAVK).FallberichtDer Patient hatte seit seinem 6. Lebensjahr einen insulinabhängigen 'T1D'. Im Alter von 39 Jahren entwickelte er eine fortschreitende bilaterale periphere arterielle Verschlusskrankheit (pAVK) der Oberschenkelarterien. Bei einer Gehstrecke von 150 m zeigte er Claudicatio-Symptome. Es wurden 10 chirurgische Eingriffe zur Rekanalisation durchgeführt. Die pAVK stellte für den Patienten eine starke psychische Belastung dar. Er entwickelte eine mittelschwere Depression mit Angstzuständen und klagte über Tinnitus und Schlafstörungen. Durch eine erste ambulante ayurvedische Behandlung, die sich hauptsächlich auf Ernährungs-, Lebensstiländerungen und Phytotherapeutika konzentrierte, und eine anschließende 6-wöchige stationäre ayurvedische Behandlung in Indien wurde eine Gewichtsreduktion um 12 kg, eine Reduzierung des Insul

引言:阿育吠陀治疗2型糖尿病(t2d)的效果有充分的文献记载。对于1型糖尿病(t1d)患者,几乎没有证据表明阿育吠陀疗法的适用性。该病例说明了一名t1d伴外周动脉闭塞性疾病(PAOD)患者的阿育吠陀治疗过程。病例介绍:该患者自6岁起就患有胰岛素依赖性t1d。39岁时,他患上了进行性双侧股动脉外周动脉闭塞性疾病(PAOD)。他在步行150米时出现跛行症状。已经进行了10次再通手术干预。PAOD给病人带来了沉重的心理压力。他出现了中度抑郁和焦虑,并抱怨耳鸣和睡眠障碍。通过最初的门诊阿育吠陀治疗,重点是饮食和生活方式的改变,植物疗法,以及随后在印度进行的为期6周的住院阿育吠吠陀治疗可以减轻12公斤的体重,将胰岛素需求降低到基线的65%,以及在中等负荷下无限制的行走性能。抑郁和内心紧张完全消退,单侧耳鸣,现有的睡眠障碍完全消失。住院5个月后,仍能感觉到持续的效果。结论:对于患有PAOD的t1d患者,门诊和住院阿育吠陀治疗可以显著改善他的情况。该案例表明,t1d患者可以从个性化的阿育吠陀治疗中受益。这个案例促使人们投资于针对t1d和并发症患者的阿育吠陀研究。
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引用次数: 0
Individualized Homeopathic Medicines in the Treatment of Post-COVID-19 Fatigue in Adults: Single-Blind, Randomized, Placebo-Controlled Trial. 个体化顺势疗法药物治疗成人covid -19后疲劳:一项单盲、随机、安慰剂对照试验
IF 1.8 4区 医学 Q2 Medicine Pub Date : 2024-01-01 Epub Date: 2023-11-26 DOI: 10.1159/000535279
Sangita Saha, Rakesh Singh, Ishika Mani, Kalyan Chakraborty, Paulami Sarkar, Subhranil Saha, Abhijit Rana, Rajat Chattopadhyay

Introduction: The coronavirus disease 2019 (COVID-19) is leading to unknown and unusual health conditions that are challenging to manage. Post-COVID-19 fatigue is one of those challenges, becoming increasingly common as the pandemic evolves, as it impairs the quality of life of an individual. This trial attempts to identify the preliminary evidence of the efficacy of individualized homeopathic medicines (IHMs) against placebos in the treatment of post-COVID-19 fatigue in adults.

Methods: A 3-month, single-blind, randomized, placebo-controlled, parallel-arm trial was conducted at the outpatient department of The Calcutta Homoeopathic Medical College and Hospital, India. Sixty participants were randomized in a 1:1 ratio to receive either IHMs (n = 30) or identical-looking placebos (n = 30). The primary and secondary outcome measures were the Fatigue Assessment Scale (FAS) and Outcome in Relation to Impact on Daily Living (ORIDL), respectively, measured every month, for up to 3 months. Comparative analysis was carried out on the intention-to-treat sample to detect group differences.

Results: Group differences in both the primary (FAS total: F1, 58 = 14.356, p < 0.001) and secondary outcomes (ORIDL: F1, 58 = 210.986, p < 0.001) after 3 months favored IHMs against placebos. Lycopodium clavatum (11.7%), sulfur (11.7%), Arsenicum album (10%), and Thuja occidentalis (10%) were the most frequently indicated medicines. No harm, unintended effects, homeopathic aggravations, or any serious adverse events were reported from either of the groups.

Conclusion: IHMs produced significantly better effects than placebos in the treatment of post-COVID-19 fatigue in adults. Definitive robust trials may be undertaken to confirm the findings.

EinleitungDie Coronainfektion (COVID-19) zieht unbekannte und ungewöhnliche gesundheitliche Probleme nach sich, deren Management oft eine Herausforderung darstellt. Das gilt unter anderem für Ermüdung nach einer COVID-19-Erkrankung, die mit zunehmender Dauer der Pandemie immer häufiger auftritt und die Lebensqualität der Betroffenen beeinträchtigt. In dieser Studie wird versucht, vorläufige Belege für die Wirksamkeit individualisierter homöopathischer Mittel (IHM) im Vergleich zu Placebo zur Behandlung von Ermüdung nach COVID-19 bei Erwachsenen zu identifizieren.MethodenEine einfach verblindete, randomisierte, placebokontrollierte Parallelgruppenstudie von 3 Monaten Dauer wurde im ambulanten Bereich des Calcutta Homoeopathic Medical College and Hospital in Indien durchgeführt. 60 Teilnehmer erhielten nach Randomisierung im Verhältnis 1:1 entweder IHM (n = 30) oder identisch aussehendes Placebo (n = 30). Die primäre und die sekundäre Zielgröße waren die Fatigue Assessment Scale (FAS) und das Outcome in Relation to Impact on Daily Living (ORIDL) für bis zu 3 Monate, je

新型冠状病毒病(COVID-19)正在导致未知和不寻常的健康状况,这些状况极具挑战性。covid -19后疲劳就是其中一项挑战,随着疫情的发展,这种挑战变得越来越普遍,因为它会损害个人的生活质量。本试验试图确定个体化顺势疗法药物(IHMs)在治疗成人covid -19后疲劳方面优于安慰剂的初步证据。方法:在印度加尔各答顺势疗法医学院门诊部进行了一项为期3个月的单盲、随机、安慰剂对照、平行对照试验。60名参与者以1:1的比例随机分配,接受ihm (n = 30)或相同外观的安慰剂(n = 30)。主要和次要结果测量分别是疲劳评估量表(FAS)和与日常生活影响相关的结果(ORIDL),每个月测量一次,持续3个月。对意向治疗样本进行对比分析,检测组间差异。结果:3个月后的主要结局(FAS total: F1, 58 = 14.356, P < 0.001)和次要结局(ORIDL: F1, 58 = 210.986, P < 0.001)的组间差异均有利于ihm组优于安慰剂组。最常使用的药物为石蒜(11.7%)、硫(11.7%)、砷(10%)和西花(10%)。两组均未报告任何伤害、意外效应、顺势疗法加重或任何严重不良事件。结论:IHMs治疗成人covid -19后疲劳的效果明显优于安慰剂。可以进行明确、有力的试验来证实这些发现。试验报名:CTRI/2022/03/041316。
{"title":"Individualized Homeopathic Medicines in the Treatment of Post-COVID-19 Fatigue in Adults: Single-Blind, Randomized, Placebo-Controlled Trial.","authors":"Sangita Saha, Rakesh Singh, Ishika Mani, Kalyan Chakraborty, Paulami Sarkar, Subhranil Saha, Abhijit Rana, Rajat Chattopadhyay","doi":"10.1159/000535279","DOIUrl":"10.1159/000535279","url":null,"abstract":"<p><strong>Introduction: </strong>The coronavirus disease 2019 (COVID-19) is leading to unknown and unusual health conditions that are challenging to manage. Post-COVID-19 fatigue is one of those challenges, becoming increasingly common as the pandemic evolves, as it impairs the quality of life of an individual. This trial attempts to identify the preliminary evidence of the efficacy of individualized homeopathic medicines (IHMs) against placebos in the treatment of post-COVID-19 fatigue in adults.</p><p><strong>Methods: </strong>A 3-month, single-blind, randomized, placebo-controlled, parallel-arm trial was conducted at the outpatient department of The Calcutta Homoeopathic Medical College and Hospital, India. Sixty participants were randomized in a 1:1 ratio to receive either IHMs (n = 30) or identical-looking placebos (n = 30). The primary and secondary outcome measures were the Fatigue Assessment Scale (FAS) and Outcome in Relation to Impact on Daily Living (ORIDL), respectively, measured every month, for up to 3 months. Comparative analysis was carried out on the intention-to-treat sample to detect group differences.</p><p><strong>Results: </strong>Group differences in both the primary (FAS total: F1, 58 = 14.356, p &lt; 0.001) and secondary outcomes (ORIDL: F1, 58 = 210.986, p &lt; 0.001) after 3 months favored IHMs against placebos. Lycopodium clavatum (11.7%), sulfur (11.7%), Arsenicum album (10%), and Thuja occidentalis (10%) were the most frequently indicated medicines. No harm, unintended effects, homeopathic aggravations, or any serious adverse events were reported from either of the groups.</p><p><strong>Conclusion: </strong>IHMs produced significantly better effects than placebos in the treatment of post-COVID-19 fatigue in adults. Definitive robust trials may be undertaken to confirm the findings.</p><p><p><title>Einleitung</title>Die Coronainfektion (COVID-19) zieht unbekannte und ungewöhnliche gesundheitliche Probleme nach sich, deren Management oft eine Herausforderung darstellt. Das gilt unter anderem für Ermüdung nach einer COVID-19-Erkrankung, die mit zunehmender Dauer der Pandemie immer häufiger auftritt und die Lebensqualität der Betroffenen beeinträchtigt. In dieser Studie wird versucht, vorläufige Belege für die Wirksamkeit individualisierter homöopathischer Mittel (IHM) im Vergleich zu Placebo zur Behandlung von Ermüdung nach COVID-19 bei Erwachsenen zu identifizieren.<title>Methoden</title>Eine einfach verblindete, randomisierte, placebokontrollierte Parallelgruppenstudie von 3 Monaten Dauer wurde im ambulanten Bereich des Calcutta Homoeopathic Medical College and Hospital in Indien durchgeführt. 60 Teilnehmer erhielten nach Randomisierung im Verhältnis 1:1 entweder IHM (<italic>n</italic> = 30) oder identisch aussehendes Placebo (<italic>n</italic> = 30). Die primäre und die sekundäre Zielgröße waren die Fatigue Assessment Scale (FAS) und das Outcome in Relation to Impact on Daily Living (ORIDL) für bis zu 3 Monate, je","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138440346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Complementary Medicine Research
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