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Herbal Treatment of Female Urogenital Atrophy: A Retrospective Cohort Analysis. 女性泌尿生殖器萎缩的草药治疗:回顾性队列分析
IF 1.8 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-01-01 Epub Date: 2024-01-11 DOI: 10.1159/000536193
Dorin Ritzmann
<p><strong>Introduction: </strong>Urogenital atrophy and its sequelae, particularly genital dryness, urological problems, and pain on genital touching, are common medical problems for menopausal women and women undergoing antihormonal cancer treatment. To meet the requirements for a nonhormonal local treatment, a compounded herbal preparation was developed as a vaginal ovule (Dioscorea comp. ovulum), and the efficacy and applicability of this herbal treatment were investigated.</p><p><strong>Methods: </strong>This was a retrospective chart review of patients' records. The study was approved by the Ethics Committee of the Canton of Zurich (project number BASEC 2016-01982). Between 2007 and 2011, patients with urogenital atrophy and related symptoms, who wanted to initiate herbal treatment, were asked for consent to be interviewed (4-point rating scale) and examined gynecologically with photo documentation of their vaginal discharge. A total of 26 patients met the enrollment criteria and consented to the procedure. The first 8 weeks consisted of a daily application of low-dose Dioscorea comp. ovulum followed by high-dose Dioscorea comp. ovule twice weekly for at least 3 months.</p><p><strong>Result: </strong>A total of 23 patients completed the trial. Of the 19 patients in the subgroup with an atrophic vaginal maturation index (VMI), 16 achieved a eutrophic VMI. Four patients began therapy with hypotrophy. There was a 96% decrease in complaints (22/23). The genital dryness score decreased from 1.80 to 0.25 points, urological problems from 2.38 to 0.85 points, and pain on genital touching from 1.70 to 0.60 points. Application, tolerability, and medical safety of the formula were good.</p><p><strong>Conclusion: </strong>The phytotherapeutic compounded preparation Dioscorea comp. ovule (Dioscorea villosa, Glycine max, Salvia officinalis) is suitable for the treatment of urogenital atrophy and its sequelae.</p><p><p><title>Hintergrund</title>Urogenitale Atrophie und ihre Folgeerscheinungen, insbesondere genitale Trockenheit, urologische Probleme und schmerzhafte genitale Berührungen, sind ein häufiges medizinisches Problem bei menopausalen Frauen und Frauen unter antihormoneller Krebstherapie. Um den Bedarf an einer nicht-hormonellen lokalen Behandlung zu decken, wurde ein pflanzliches Präparat in Form eines Vaginal-Ovulum (<italic>Dioscorea</italic> comp. Ovulum) entwickelt. Wirksamkeit und Anwendbarkeit dieser pflanzlichen Behandlung werden untersucht.<title>Patientinnen und Methoden</title>Es handelt sich um eine retrospektive Analyse. Das Studienprotokoll wurde von der Ethikkommission des Kantons Zürich genehmigt (Projekt Nummer BASEC 2016-01982). Zwischen 2007 und 2011 wurden geeignete Patientinnen mit urogenitaler Atrophie und assoziierten Beschwerden, die mit einer pflanzlichen Behandlung beginnen wollten, um ihr Einverständnis zu einer Befragung (4-Punkte-Score) und gynäkologischen Untersuchungen mit Fotodokumentation des Vaginalausflusses (Nat
背景:泌尿生殖器萎缩及其后遗症,尤其是生殖器干涩、泌尿系统问题和生殖器触摸疼痛,是更年期妇女和接受抗激素癌症治疗的妇女常见的医学问题。为了满足非激素局部治疗的要求,我们开发了一种复方草药制剂--阴道卵巢(薯蓣皂苷卵巢),并对这种草药治疗的疗效和适用性进行了研究:这是一项回顾性病历审查。研究获得了苏黎世州伦理委员会的批准(项目编号 BASEC 2016-01982)。2007 年至 2011 年间,研究人员征得了希望开始接受草药治疗的泌尿生殖器萎缩及相关症状患者的同意,对其进行了访谈(4 分制评分表),并对其进行了妇科检查,同时提供了阴道分泌物的照片记录。共有 26 名患者符合入选标准并同意接受治疗。治疗:前 8 周每天使用低剂量的薯蓣皂苷,然后使用高剂量的薯蓣皂苷,每周两次,持续至少 3 个月:结果:共有 23 名患者完成了试验。在萎缩性阴道成熟指数(VMI)亚组的 19 名患者中,有 16 名患者的 VMI 达到了中度萎缩。四名患者在开始治疗时阴道萎缩。主诉减少了 96%(22/23)。生殖器干涩评分从 1.80 分降至 0.25 分,泌尿系统问题评分从 2.38 分降至 0.85 分,生殖器触摸疼痛评分从 1.70 分降至 0.60 分。该配方的应用性、耐受性和医疗安全性良好:植物疗法复方制剂 Di-oscorea comp. ovule(薯蓣、甘草、丹参)适用于治疗泌尿生殖器萎缩及其后遗症。该研究的预印本已于2020年7月16日在www.authorea.com [DOI: 10.22541/au.159493095.52457248]。
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引用次数: 0
Effectiveness of Alternative Nostril Breathing on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 替代鼻孔呼吸对血压的影响:随机对照试验的系统回顾和元分析》。
IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-01-01 Epub Date: 2024-07-15 DOI: 10.1159/000539707
Tae Gwang Nam, Hyein Jeong, Kyeong Han Kim, Insoo Jang

Introduction: Hypertension, a significant risk factor for cardiovascular disease, has a high prevalence rate globally. While drug use is the most common approach, lifestyle improvements are crucial. Recently, there has been a notable upsurge of interest in various breathing methods, including device-induced breathing techniques like Resperate. However, the reliance on a device for these techniques has prompted the popularity of alternative breathing methods that can be performed without any external devices. One such method that has gained significant attention is alternative nostril breathing, which serves as an alternative medical treatment known for its effectiveness in reducing blood pressure. Therefore, this study aimed to systematically investigate the therapeutic effects of alternate nostril breathing.

Methods: We selected 16 articles published in English, Korean, and Chinese databases, of which 14 met the eligibility criteria, and a systematic literature review was conducted. A meta-analysis was conducted on six qualified studies. Meta and sensitivity analyses were conducted using a random effects model of six randomized clinical trials (RCTs).

Results: Results of alternative nostril breathing (ANB) on 1,377 participants have been reported based on the effects of systolic and diastolic blood pressure (SBP and DBP). Both the lone ANB and combined yoga programs resulted in significant reductions in SBP and DBP. Meta-analysis of the 6 trials with 525 participants demonstrated that ANB was better in reducing SBP than that of the control group (nonintervention or placebo) (mean difference [MD]: -7.16, 95% confidence interval [CI]: -7.86 to -6.45, I2: 93%). Moreover, ANB was better in reducing DBP than that of the control group (nonintervention or placebo) (MD: -5.16, 95% CI: -5.89 to -4.44, I2: 87%).

Conclusion: The results of the study are valid; however, attention is needed when interpreting the results because the heterogeneity exceeds 75%. A systematic review of 14 studies found that ANB can improve cardiovascular indicators, such as SBP and DBP, as well as non-cardiovascular factors, such as fatigue, intraocular pressure, and memory. However, the review noted that implementing double blinding in studies on yoga breathing intervention is difficult, and most studies were not double-blinded, suggesting the need for high-quality RCTs in the future.

高血压是心血管疾病的重要风险因素,在全球的发病率很高。虽然药物治疗是最常见的方法,但改善生活方式也至关重要。最近,人们对各种呼吸方法的兴趣明显增加,包括 Resperate 等设备诱导呼吸技术。然而,这些技术对设备的依赖促使无需任何外部设备即可进行的替代呼吸方法大受欢迎。替代鼻孔呼吸法就是其中一种备受关注的方法,它是一种以有效降低血压而闻名的替代医疗方法。因此,本研究旨在系统地调查替代鼻孔呼吸法的治疗效果。我们选择了发表在英文、韩文和中文数据库中的 16 篇文章,其中 14 篇符合资格标准,并进行了系统的文献综述。对 6 项合格的研究进行了荟萃分析。使用随机效应模型对六项随机临床试验(RCT)进行了元分析和敏感性分析。根据收缩压和舒张压(SBP 和 DBP)的影响,对 1,377 名参与者进行了替代鼻孔呼吸(ANB)的结果报告。单独的替代鼻孔呼吸和组合瑜伽计划都能显著降低收缩压和舒张压。对 6 项有 525 名参与者的试验进行的 Meta 分析表明,ANB 在降低 SBP 方面优于对照组(非干预或安慰剂)(平均差 [MD]:-7.16,95% 置信区间 [CI]:-7.86 至 -6.45,I2:93%)。此外,ANB 在降低 DBP 方面的效果优于对照组(非干预组或安慰剂组)(MD:-5.16,95% 置信区间:-5.89 至 -4.44,I2:87%)。研究结果是有效的,但在解释结果时需要注意,因为异质性超过了 75%。一项针对 14 项研究的系统性综述发现,ANB 可以改善 SBP 和 DBP 等心血管指标,以及疲劳、眼压和记忆力等非心血管因素。然而,综述指出,在瑜伽呼吸干预研究中实施双盲很困难,而且大多数研究都没有双盲,这表明今后需要进行高质量的 RCT 研究。注册:注册号:CRD42023401177。
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引用次数: 0
Society Bulletins · Gesellschaftsmitteilungen. 学会公告 - 学会公告。
IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-01-01 Epub Date: 2024-08-06 DOI: 10.1159/000540201
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引用次数: 0
Efficacy and Safety of Acupuncture Combined with Herbal Medicine for Children and Adolescents with Tourette Syndrome: A Systematic Review and Meta-Analysis. 针灸结合中药治疗儿童青少年抽动秽语综合征的疗效和安全性:系统综述和荟萃分析。
IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-01-01 Epub Date: 2023-10-16 DOI: 10.1159/000534115
Jiawei Li, Chuncai Li, Yuqi Ma, Mingxing Yuan, Yuan Liu
<p><strong>Background: </strong>With the increasing prevalence of Tourette syndrome (TS), the search for alternative therapy for TS is a growing public concern. In recent years, a growing number of randomized controlled trials (RCTs) have revealed the value of acupuncture combined with herbal medicine for the treatment of TS; however, its holistic efficacy and safety remains unclear. This study aimed to evaluate the efficacy and safety of acupuncture combined with herbal medicine and to provide preliminary evidence for clinical practice.</p><p><strong>Methods: </strong>Eight databases were searched from their establishment to November 27, 2022, to collect RCTs of acupuncture combined with herbal medicine for TS treatment. Two researchers independently completed the study screening, data extraction, and risk of bias assessment by using NoteExpress, Excel, and Cochrane Risk of Bias Tool 2.0 (RoB 2.0). Stata 15.0 software was applied to conduct meta-analysis.</p><p><strong>Results: </strong>A total of 1,400 participants in 18 RCTs were included. Compared with the Western medicine, acupuncture combined with herbal medicine had better curative effect in the field of effective rate (risk ratio [RR] = 1.18, 95% CI: [1.12, 1.23], p < 0.05, I2 = 0%), Yale Global Tic Severity Scale (YGTSS) total score (mean difference [MD] = -3.91, 95% CI: [-5.49, -2.33], p < 0.05, I2 = 96.4%), TCM syndrome total score (MD = -2.42, 95% CI: [-3.71, -1.13], p < 0.05, I2 = 87.1%), and serum IgE negative rate (RR = 3.41, 95% CI: [1.69, 6.87], p < 0.05, I2 = 0%). Furthermore, acupuncture combined with herbal medicine reduced the adverse reaction rate (RR = 0.20, 95% CI: [0.14, 0.30], p < 0.05, I2 = 0%) and the recurrence rate (RR = 0.27, 95% CI: [0.13, 0.52], p < 0.05, I2 = 0%).</p><p><strong>Conclusion: </strong>This study demonstrated the efficacy and safety of acupuncture combined with herbal medicine, which is probably a better alternative therapy for TS. However, the small number, low quality, and potential bias of the included studies caused the limitations of our results. More high-quality RCTs are required to provide supplementary evidence in the future.</p><p><p><title>Hintergrund</title>Mit der steigenden Prävalenz des Tourette-Syndroms (TS) ist die Suche nach alternativen Therapien für TS zunehmend zu einer Angelegenheit von öffentlichem Interesse geworden. In den vergangenen Jahren zeigte eine immer größer werdende Zahl randomisierter, kontrollierter Studien den Nutzen der Akupunktur in Kombination mit Heilkräutern; ihre ganzheitliche Wirksamkeit und Sicherheit ist jedoch weiterhin nicht klar. Mit dieser Studie sollten die Wirksamkeit und Sicherheit von Akupunktur in Kombination mit Heilkräutern beurteilt und erste Belege für die klinische Praxis gewonnen werden.<title>Methoden</title>Acht (8) Datenbanken wurden ab ihrer Einrichtung bis zum 27. November 2022 nach randomisierten kontrollierten Studien (RCTs) über Akupunktur in Kombination mit Heilkr
背景:随着抽动秽语综合征(TS)的日益流行,寻找TS的替代治疗方法越来越受到公众的关注。近年来,越来越多的随机对照试验揭示了针灸结合中药治疗TS的价值;然而,其整体疗效和安全性尚不清楚。本研究旨在评价针药结合的疗效和安全性,为临床实践提供初步依据。方法:检索从建立到2022年11月27日的8个数据库,收集针灸联合中药治疗TS的随机对照试验。两名研究人员使用NoteExpress、Excel和Cochrane risk of bias Tool 2.0(RoB 2.0)独立完成了研究筛选、数据提取和偏倚风险评估。应用Stata 15.0软件进行荟萃分析。结果:共有1400名参与者参加了18项随机对照试验。针药结合治疗有效率(RR=1.18,95%CI[1.12,1.23],P<0.05,I²=0%)、耶鲁综合Tic严重程度量表(YGTSS)总分(MD=-3.91,95%CI[5.49,-2.33],P>0.05,中医证候总分(MD=2.42,95%CI[-3.71,-1.13],P<0.05,I²=87.1%)和血清IgE阴性率(RR=3.41,95%CI[1.69,6.87],P<0.01,I²=0%)。此外,针药结合降低了不良反应发生率(RR=0.20,95%CI[0.14,0.30],P<0.05,I²=0%)和复发率(RR=0.027,95%CI[0.13,0.52],P<05,I²=0%),纳入的研究数量少、质量低、潜在的偏倚导致了我们研究结果的局限性。未来需要更多高质量的随机对照试验来提供补充证据。
{"title":"Efficacy and Safety of Acupuncture Combined with Herbal Medicine for Children and Adolescents with Tourette Syndrome: A Systematic Review and Meta-Analysis.","authors":"Jiawei Li, Chuncai Li, Yuqi Ma, Mingxing Yuan, Yuan Liu","doi":"10.1159/000534115","DOIUrl":"10.1159/000534115","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;With the increasing prevalence of Tourette syndrome (TS), the search for alternative therapy for TS is a growing public concern. In recent years, a growing number of randomized controlled trials (RCTs) have revealed the value of acupuncture combined with herbal medicine for the treatment of TS; however, its holistic efficacy and safety remains unclear. This study aimed to evaluate the efficacy and safety of acupuncture combined with herbal medicine and to provide preliminary evidence for clinical practice.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Eight databases were searched from their establishment to November 27, 2022, to collect RCTs of acupuncture combined with herbal medicine for TS treatment. Two researchers independently completed the study screening, data extraction, and risk of bias assessment by using NoteExpress, Excel, and Cochrane Risk of Bias Tool 2.0 (RoB 2.0). Stata 15.0 software was applied to conduct meta-analysis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 1,400 participants in 18 RCTs were included. Compared with the Western medicine, acupuncture combined with herbal medicine had better curative effect in the field of effective rate (risk ratio [RR] = 1.18, 95% CI: [1.12, 1.23], p &lt; 0.05, I2 = 0%), Yale Global Tic Severity Scale (YGTSS) total score (mean difference [MD] = -3.91, 95% CI: [-5.49, -2.33], p &lt; 0.05, I2 = 96.4%), TCM syndrome total score (MD = -2.42, 95% CI: [-3.71, -1.13], p &lt; 0.05, I2 = 87.1%), and serum IgE negative rate (RR = 3.41, 95% CI: [1.69, 6.87], p &lt; 0.05, I2 = 0%). Furthermore, acupuncture combined with herbal medicine reduced the adverse reaction rate (RR = 0.20, 95% CI: [0.14, 0.30], p &lt; 0.05, I2 = 0%) and the recurrence rate (RR = 0.27, 95% CI: [0.13, 0.52], p &lt; 0.05, I2 = 0%).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;This study demonstrated the efficacy and safety of acupuncture combined with herbal medicine, which is probably a better alternative therapy for TS. However, the small number, low quality, and potential bias of the included studies caused the limitations of our results. More high-quality RCTs are required to provide supplementary evidence in the future.&lt;/p&gt;&lt;p&gt;&lt;p&gt;&lt;title&gt;Hintergrund&lt;/title&gt;Mit der steigenden Prävalenz des Tourette-Syndroms (TS) ist die Suche nach alternativen Therapien für TS zunehmend zu einer Angelegenheit von öffentlichem Interesse geworden. In den vergangenen Jahren zeigte eine immer größer werdende Zahl randomisierter, kontrollierter Studien den Nutzen der Akupunktur in Kombination mit Heilkräutern; ihre ganzheitliche Wirksamkeit und Sicherheit ist jedoch weiterhin nicht klar. Mit dieser Studie sollten die Wirksamkeit und Sicherheit von Akupunktur in Kombination mit Heilkräutern beurteilt und erste Belege für die klinische Praxis gewonnen werden.&lt;title&gt;Methoden&lt;/title&gt;Acht (8) Datenbanken wurden ab ihrer Einrichtung bis zum 27. November 2022 nach randomisierten kontrollierten Studien (RCTs) über Akupunktur in Kombination mit Heilkr","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"40-55"},"PeriodicalIF":1.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41232921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Huanglian Jiedu Decoction for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. 黄连解毒汤对 2 型糖尿病的疗效:系统回顾与元分析》。
IF 1.8 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-01-01 Epub Date: 2024-01-29 DOI: 10.1159/000536453
Menglong Wang, Tongrui Wang, Feng Gu
<p><strong>Objective: </strong>Type 2 diabetes mellitus (T2DM) is a prevalent metabolic disorder, and there is an increasing interest in the potential benefits of traditional Chinese medicine, such as Huanglian Jiedu decoction (HJD), for its management. This meta-analysis aimed to determine the efficacy and safety of HJD in the treatment of T2DM.</p><p><strong>Methods: </strong>A systematic review was conducted across six databases including PubMed, Embase, Cochrane, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang, from their inception to August 24, 2023. We focused on randomized controlled trials (RCTs) that evaluated HJD as both a monotherapy and in combination treatments for T2DM patients. Data analysis was performed using RevMan 5.3 and Stata 17.0, with evaluations for heterogeneity and publication bias. Additionally, subgroup analyses were stratified based on the duration of treatment.</p><p><strong>Results: </strong>A total of 40 studies involving 3,934 participants were included in the meta-analysis. Both HJD monotherapy and combined with other therapies significantly reduced hemoglobin A1C (HbA1c) fasting blood glucose (FBG) and 2-h postprandial glucose (2hPG) levels, as well as improved insulin resistance. Furthermore, combination therapy enhanced the efficacy rate and favorably altered lipid profiles, including increasing HDL-C and decreasing LDL-C, TC, and TG levels. It was worth noting that the results of the subgroup analysis indicated that, in terms of reducing HbA1c and 2hPG, the efficacy of HJD alone for a duration of less than 3 months was found to be potentially superior to that observed in treatments exceeding 3 months. Adverse event assessment suggested that HJD did not increase the incidence of side effects, including diarrhea, affirming its safety.</p><p><strong>Conclusion: </strong>HJD appears to be an effective and safe alternative or adjunctive therapy for T2DM, showing significant improvements in glycemic control and lipid profiles without increasing adverse events. Further rigorous, multicenter RCTs outside China are warranted to validate these findings.</p><p><p><title>Ziel</title>Diabetes mellitus Typ 2 (DMT2) ist eine weit verbreitete Stoffwechselerkrankung, und es besteht ein steigendes Interesse an den potenziellen Vorteilen der traditionellen chinesischen Medizin, wie beispielsweise Huanglian Jiedu-Dekokt (HJD), zu seiner Behandlung. Mit dieser Metaanalyse sollten die Wirksamkeit und Sicherheit von HJD zur Behandlung von DMT2 ermittelt werden.<title>Methoden</title>Es wurde eine systematische Recherche in sechs Datenbanken durchgeführt, darunter PubMed, Embase, Cochrane, Web of Science, China National Knowledge Infrastructure (CNKI) und Wanfang, für die Zeit vom Beginn der Datenbank bis zum 24. August 2023. Dabei lag unser Hauptaugenmerk auf randomisierten kontrollierten Studien (RCTs), die HJD sowohl als Monotherapie als auch in Kombinationstherapien bei Patienten mit DMT2 untersuchten
目的:2型糖尿病(T2DM)是一种常见的代谢性疾病,人们越来越关注传统中药(如黄连解毒汤)对治疗T2DM的潜在益处。本荟萃分析旨在确定黄连解毒汤治疗 T2DM 的有效性和安全性:方法:我们在 PubMed、Embase、Cochrane、Web of Science、中国国家知识基础设施(CNKI)和万方等六个数据库中进行了系统综述,时间跨度从开始到 2023 年 8 月 24 日。我们重点研究了评估 HJD 作为 T2DM 患者单一疗法或联合疗法的随机对照试验 (RCT)。我们使用 RevMan 5.3 和 Stata 17.0 进行了数据分析,并对异质性和发表偏倚进行了评估。此外,还根据治疗持续时间进行了亚组分析:荟萃分析共纳入了 40 项研究,涉及 3,934 名参与者。HJD单药治疗和与其他疗法联合治疗均能显著降低HbA1c空腹血糖(FBG)和餐后2小时血糖(2hPG)水平,并改善胰岛素抵抗。此外,联合疗法提高了有效率,并有利地改变了血脂状况,包括增加高密度脂蛋白胆固醇(HDL-C),降低低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)和总胆固醇(TG)水平。值得注意的是,亚组分析结果表明,在降低 HbA1c 和 2hPG 方面,疗程少于 3 个月的单用 HJD 的疗效可能优于疗程超过 3 个月的疗效。不良事件评估表明,HJD 不会增加腹泻等副作用的发生率,这肯定了其安全性:结论:HJD 似乎是治疗 T2DM 的一种有效而安全的替代或辅助疗法,可显著改善血糖控制和血脂状况,且不会增加不良反应。有必要在中国以外地区进一步开展严格的多中心 RCT 研究,以验证这些研究结果。
{"title":"Efficacy of Huanglian Jiedu Decoction for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.","authors":"Menglong Wang, Tongrui Wang, Feng Gu","doi":"10.1159/000536453","DOIUrl":"10.1159/000536453","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Type 2 diabetes mellitus (T2DM) is a prevalent metabolic disorder, and there is an increasing interest in the potential benefits of traditional Chinese medicine, such as Huanglian Jiedu decoction (HJD), for its management. This meta-analysis aimed to determine the efficacy and safety of HJD in the treatment of T2DM.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A systematic review was conducted across six databases including PubMed, Embase, Cochrane, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang, from their inception to August 24, 2023. We focused on randomized controlled trials (RCTs) that evaluated HJD as both a monotherapy and in combination treatments for T2DM patients. Data analysis was performed using RevMan 5.3 and Stata 17.0, with evaluations for heterogeneity and publication bias. Additionally, subgroup analyses were stratified based on the duration of treatment.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 40 studies involving 3,934 participants were included in the meta-analysis. Both HJD monotherapy and combined with other therapies significantly reduced hemoglobin A1C (HbA1c) fasting blood glucose (FBG) and 2-h postprandial glucose (2hPG) levels, as well as improved insulin resistance. Furthermore, combination therapy enhanced the efficacy rate and favorably altered lipid profiles, including increasing HDL-C and decreasing LDL-C, TC, and TG levels. It was worth noting that the results of the subgroup analysis indicated that, in terms of reducing HbA1c and 2hPG, the efficacy of HJD alone for a duration of less than 3 months was found to be potentially superior to that observed in treatments exceeding 3 months. Adverse event assessment suggested that HJD did not increase the incidence of side effects, including diarrhea, affirming its safety.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;HJD appears to be an effective and safe alternative or adjunctive therapy for T2DM, showing significant improvements in glycemic control and lipid profiles without increasing adverse events. Further rigorous, multicenter RCTs outside China are warranted to validate these findings.&lt;/p&gt;&lt;p&gt;&lt;p&gt;&lt;title&gt;Ziel&lt;/title&gt;Diabetes mellitus Typ 2 (DMT2) ist eine weit verbreitete Stoffwechselerkrankung, und es besteht ein steigendes Interesse an den potenziellen Vorteilen der traditionellen chinesischen Medizin, wie beispielsweise Huanglian Jiedu-Dekokt (HJD), zu seiner Behandlung. Mit dieser Metaanalyse sollten die Wirksamkeit und Sicherheit von HJD zur Behandlung von DMT2 ermittelt werden.&lt;title&gt;Methoden&lt;/title&gt;Es wurde eine systematische Recherche in sechs Datenbanken durchgeführt, darunter PubMed, Embase, Cochrane, Web of Science, China National Knowledge Infrastructure (CNKI) und Wanfang, für die Zeit vom Beginn der Datenbank bis zum 24. August 2023. Dabei lag unser Hauptaugenmerk auf randomisierten kontrollierten Studien (RCTs), die HJD sowohl als Monotherapie als auch in Kombinationstherapien bei Patienten mit DMT2 untersuchten","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"187-200"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139575453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Society Bulletins · Gesellschaftsmitteilungen. 学会公告 - 学会公告。
IF 1.8 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-01-01 Epub Date: 2024-03-18 DOI: 10.1159/000538325
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引用次数: 0
The Tibetan Formula Cong zhi 6 in the ORL (ENT) Practice: Experiences with Laryngopharyngeal Reflux. 藏方从治六在喉喉科(耳鼻喉科)实践中的应用:治疗喉咽反流(LPR)的体会。
IF 1.8 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-01-01 Epub Date: 2023-11-11 DOI: 10.1159/000534212
Barbara Friederike Zürcher
<p><strong>Background: </strong>Laryngopharyngeal reflux (LPR) is a frequent condition; in European countries, the prevalence can be estimated as 10-30% of the general population. Treatment includes lifestyle measures and highly dosed proton pump inhibitors (PPIs) over at least 4 weeks. However, PPIs are not unproblematic due to their potential side effects and the known phenomenon of rebound acid hypersecretion. Cong zhi 6 is a multi-herbal Tibetan formula additionally containing calcium carbonate and is available in several European countries as a food supplement Padma Aciben/Padma AciTib.</p><p><strong>Case report: </strong>Ten patients with LPR took Cong zhi 6. The course of the complaints was documented, and the data were retrospectively analysed. Clinical symptoms as assessed with the Reflux Symptom Index (RSI) questionnaire and the findings in laryngoscopy with the Reflux Finding Score (RFS) both showed marked improvement of several symptoms. The number of patients with pathological LPR sum score was significantly reduced from 8 to 2 patients and from 10 to 1 patient in RSI and RFS, respectively. The mean sum scores were reduced from 18.1 to 8.4 (RSI) and from 12.9 to 4.4 (RFS), respectively. Also, other gastrointestinal symptoms, such as abdominal pain, bloating, feeling of fullness, and nausea, which are usually associated with functional dyspepsia and irritable bowel syndrome, were markedly improved (reduction of mean score of the 3 most frequent symptoms by 77-87%).</p><p><strong>Conclusion: </strong>Standard medical treatment for LPR consists in high dosed PPI for at least 4 weeks, which is known for several side effects and does not treat reliable the nonacid component of LPR of pepsin or other gastric enzymes. Therefore, other medical treatment options are urgently needed. The promising data of this case series suggest that the Tibetan herbal formula Cong zhi 6 may be a treatment option in LPR and related gastrointestinal symptoms and warrant further research.</p><p><p><title>Hintergrund</title>Der laryngopharyngeale Reflux (LPR) ist eine häufige Erkrankung. In europäischen Ländern wird die Prävalenz in der Gesamtbevölkerung auf 10–30% geschätzt. Die Behandlung beinhaltet Ernährungs- und Verhaltensänderung sowie die Gabe hochdosierter Protonen-Pumpen-Hemmer (PPI) über mindestens 4 Wochen. PPI sind jedoch aufgrund ihrer hohen potenziellen Nebenwirkungen und des bekannten Rebound-Phänomens der sauren Magensafthypersekretion nicht unproblematisch. Cong zhi 6 ist eine tibetische Rezeptur aus einem Vielpflanzengemisch sowie zusätzlich Calciumcarbonat und ist in einigen europäischen Ländern als Nahrungsergänzungsmittel Padma Aciben/Padma AciTib erhältlich.<title>Case Report</title>Zehn Patienten mit laryngo-pharyngealem Reflux (LPR) nahmen Cong zhi 6 ein. Der Beschwerdeverlauf wurde dokumentiert und die Daten retrospektiv analysiert. Die klinischen Symptome, die mithilfe des Reflux Symptom Index (RSI) Fragebogens erfasst wurden und die mi
背景:喉咽反流(LPR)是一种常见的疾病,估计患病率为10-30%。治疗包括生活方式措施和高剂量质子泵抑制剂(PPI)至少4周。然而,由于其潜在的副作用和已知的反跳酸分泌过多的现象,PPI并非没有问题。聪芝是一种藏式复方草药,另外含有碳酸钙,在一些欧洲国家作为食品补充剂可以买到。病例报告:喉咽反流(LPR)患者10例。对投诉过程进行记录,并对数据进行回顾性分析。用反流症状指数(RSI)问卷评估的临床症状和用反流发现评分(RFS)进行喉镜检查的结果都显示了一些症状的显著改善。RSI组病理LPR总评分从8例减少到2例,RFS组从10例减少到1例。平均和评分分别从18.1分(RSI)和12.9分(RFS)降至8.4分和4.4分。此外,通常与功能性消化不良和肠易激综合征相关的其他胃肠道症状,如腹痛、腹胀、饱腹感和恶心均明显改善(3种最常见症状的平均评分降低77-87%)。结论:LPR的标准药物治疗包括高剂量PPI,持续至少4周,这是已知的几种副作用,并且不能可靠地治疗LPR的胃蛋白酶或其他胃酶的非酸成分。因此,迫切需要其他医疗选择。本病例系列的数据表明,藏药复方聪栀6可能是治疗LPR及相关胃肠道症状的一种有价值的选择。
{"title":"The Tibetan Formula Cong zhi 6 in the ORL (ENT) Practice: Experiences with Laryngopharyngeal Reflux.","authors":"Barbara Friederike Zürcher","doi":"10.1159/000534212","DOIUrl":"10.1159/000534212","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Laryngopharyngeal reflux (LPR) is a frequent condition; in European countries, the prevalence can be estimated as 10-30% of the general population. Treatment includes lifestyle measures and highly dosed proton pump inhibitors (PPIs) over at least 4 weeks. However, PPIs are not unproblematic due to their potential side effects and the known phenomenon of rebound acid hypersecretion. Cong zhi 6 is a multi-herbal Tibetan formula additionally containing calcium carbonate and is available in several European countries as a food supplement Padma Aciben/Padma AciTib.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Case report: &lt;/strong&gt;Ten patients with LPR took Cong zhi 6. The course of the complaints was documented, and the data were retrospectively analysed. Clinical symptoms as assessed with the Reflux Symptom Index (RSI) questionnaire and the findings in laryngoscopy with the Reflux Finding Score (RFS) both showed marked improvement of several symptoms. The number of patients with pathological LPR sum score was significantly reduced from 8 to 2 patients and from 10 to 1 patient in RSI and RFS, respectively. The mean sum scores were reduced from 18.1 to 8.4 (RSI) and from 12.9 to 4.4 (RFS), respectively. Also, other gastrointestinal symptoms, such as abdominal pain, bloating, feeling of fullness, and nausea, which are usually associated with functional dyspepsia and irritable bowel syndrome, were markedly improved (reduction of mean score of the 3 most frequent symptoms by 77-87%).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Standard medical treatment for LPR consists in high dosed PPI for at least 4 weeks, which is known for several side effects and does not treat reliable the nonacid component of LPR of pepsin or other gastric enzymes. Therefore, other medical treatment options are urgently needed. The promising data of this case series suggest that the Tibetan herbal formula Cong zhi 6 may be a treatment option in LPR and related gastrointestinal symptoms and warrant further research.&lt;/p&gt;&lt;p&gt;&lt;p&gt;&lt;title&gt;Hintergrund&lt;/title&gt;Der laryngopharyngeale Reflux (LPR) ist eine häufige Erkrankung. In europäischen Ländern wird die Prävalenz in der Gesamtbevölkerung auf 10–30% geschätzt. Die Behandlung beinhaltet Ernährungs- und Verhaltensänderung sowie die Gabe hochdosierter Protonen-Pumpen-Hemmer (PPI) über mindestens 4 Wochen. PPI sind jedoch aufgrund ihrer hohen potenziellen Nebenwirkungen und des bekannten Rebound-Phänomens der sauren Magensafthypersekretion nicht unproblematisch. Cong zhi 6 ist eine tibetische Rezeptur aus einem Vielpflanzengemisch sowie zusätzlich Calciumcarbonat und ist in einigen europäischen Ländern als Nahrungsergänzungsmittel Padma Aciben/Padma AciTib erhältlich.&lt;title&gt;Case Report&lt;/title&gt;Zehn Patienten mit laryngo-pharyngealem Reflux (LPR) nahmen Cong zhi 6 ein. Der Beschwerdeverlauf wurde dokumentiert und die Daten retrospektiv analysiert. Die klinischen Symptome, die mithilfe des Reflux Symptom Index (RSI) Fragebogens erfasst wurden und die mi","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"84-88"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89717262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Involving Voters and Consumers in Decision-Making about the Health Care System - The Swiss Case: A Review. 让选民和消费者参与医疗保健系统的决策:瑞士案例。评论。
IF 1.8 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-01-01 Epub Date: 2023-09-25 DOI: 10.1159/000534268
Robert Jütte
<p><strong>Background: </strong>Behind the principle of involving users and voters directly in decision-making about the health care system are ideas relating to empowerment. This implies a challenge to the traditional view that scientific knowledge is generally believed to be of higher value than empirical knowledge, as it is the case with CAM. The objectives of this review are (a) to show that this assumption disregards the fact that CAM is as scientific as conventional medicine but has different basic assumptions what the world is being made of and consequently uses different/adapted scientific methods; (b) to demonstrate how a perspective of the history of medicine and science as well as direct democracy mechanisms such as stipulated in the Swiss constitution can be used to achieve the acceptance of CAM in a modern medical health care system. A public health care system financed by levies from the population should also reflect the widely documented desire in the population for medical pluralism (provided that therapeutical alternatives are not risky). Otherwise, the problem of social inequality arises because only people with a good financial background can afford this medicine.</p><p><strong>Summary: </strong>From the perspective of scientific theory and the history of science, the answer to the question of whether complementary medicine and conventional medical procedures must provide proof of efficacy according to a uniform scientific is quite controversial according to epistemologically oriented studies on this issue.</p><p><strong>Key messages: </strong>This review found strong evidence for involving voters and consumers directly in decision-making about the provision of CAM in the health care system. It also seems necessary to step back in the debate on evidence-based medicine, taking a history of medicine and science perspective, as the role which the proper method occupies and plays in medicine is defined by the scientific nature of the world view.</p><p><p>Hinter dem Grundsatz, Nutzer und Wähler direkt in die Entscheidungsfindung über das Gesundheitssystem einzubeziehen, stehen Vorstellungen von Empowerment. Dies impliziert eine Infragestellung der traditionellen Ansicht, dass wissenschaftliches Wissen im Allgemeinen als wertvoller angesehen wird als empirisches Wissen und erprobte Erfahrung, wie es bei der Komplementärmedizin der Fall ist. Die Ziele dieser Übersichtsarbeit sind: (a) zu zeigen, dass diese Annahme die Tatsache außer Acht lässt, dass die Komplementärmedizin ebenso wissenschaftlich ist wie die Schulmedizin, aber von anderen Grundannahmen ausgeht, wie die Welt beschaffen ist, und folglich andere/angepasste wissenschaftliche Methoden anwendet; (b) aufzuzeigen, wie eine medizin- und wissenschaftsgeschichtliche Perspektive sowie Mechanismen der direkten Demokratie, wie sie in der Schweizer Verfassung vorgesehen sind, genutzt werden können, um die Akzeptanz der Komplementärmedizin in einem modernen medizinischen Gesundheits
让用户和选民直接参与医疗保健系统决策的原则背后是与赋权有关的理念。这意味着对传统观点的挑战,即科学知识通常被认为比久经考验的经验更有价值,就像CAM的情况一样。这篇综述的目的是展示如何从医学和科学史的角度以及瑞士宪法中规定的直接民主机制来实现CAM在现代医疗保健系统中的接受。由民众征税资助的公共卫生保健系统也应反映出民众对医疗多元化的广泛渴望(前提是治疗替代品没有风险)。否则,社会不平等的问题就会出现,因为只有有良好经济背景的人才能负担得起这种药。
{"title":"Involving Voters and Consumers in Decision-Making about the Health Care System - The Swiss Case: A Review.","authors":"Robert Jütte","doi":"10.1159/000534268","DOIUrl":"10.1159/000534268","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Behind the principle of involving users and voters directly in decision-making about the health care system are ideas relating to empowerment. This implies a challenge to the traditional view that scientific knowledge is generally believed to be of higher value than empirical knowledge, as it is the case with CAM. The objectives of this review are (a) to show that this assumption disregards the fact that CAM is as scientific as conventional medicine but has different basic assumptions what the world is being made of and consequently uses different/adapted scientific methods; (b) to demonstrate how a perspective of the history of medicine and science as well as direct democracy mechanisms such as stipulated in the Swiss constitution can be used to achieve the acceptance of CAM in a modern medical health care system. A public health care system financed by levies from the population should also reflect the widely documented desire in the population for medical pluralism (provided that therapeutical alternatives are not risky). Otherwise, the problem of social inequality arises because only people with a good financial background can afford this medicine.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Summary: &lt;/strong&gt;From the perspective of scientific theory and the history of science, the answer to the question of whether complementary medicine and conventional medical procedures must provide proof of efficacy according to a uniform scientific is quite controversial according to epistemologically oriented studies on this issue.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Key messages: &lt;/strong&gt;This review found strong evidence for involving voters and consumers directly in decision-making about the provision of CAM in the health care system. It also seems necessary to step back in the debate on evidence-based medicine, taking a history of medicine and science perspective, as the role which the proper method occupies and plays in medicine is defined by the scientific nature of the world view.&lt;/p&gt;&lt;p&gt;&lt;p&gt;Hinter dem Grundsatz, Nutzer und Wähler direkt in die Entscheidungsfindung über das Gesundheitssystem einzubeziehen, stehen Vorstellungen von Empowerment. Dies impliziert eine Infragestellung der traditionellen Ansicht, dass wissenschaftliches Wissen im Allgemeinen als wertvoller angesehen wird als empirisches Wissen und erprobte Erfahrung, wie es bei der Komplementärmedizin der Fall ist. Die Ziele dieser Übersichtsarbeit sind: (a) zu zeigen, dass diese Annahme die Tatsache außer Acht lässt, dass die Komplementärmedizin ebenso wissenschaftlich ist wie die Schulmedizin, aber von anderen Grundannahmen ausgeht, wie die Welt beschaffen ist, und folglich andere/angepasste wissenschaftliche Methoden anwendet; (b) aufzuzeigen, wie eine medizin- und wissenschaftsgeschichtliche Perspektive sowie Mechanismen der direkten Demokratie, wie sie in der Schweizer Verfassung vorgesehen sind, genutzt werden können, um die Akzeptanz der Komplementärmedizin in einem modernen medizinischen Gesundheits","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"78-83"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41117150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Fundamental Question for Complementary Medicine: Are There Other Forces in the Natural World Besides the Physical Forces? 补充医学的一个基本问题是:自然界中除了物理力之外还有其他力量吗?
IF 1.8 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-01-01 Epub Date: 2023-10-19 DOI: 10.1159/000534592
Helmut Kiene, Harald Johan Hamre
<p><strong>Background: </strong>The integration of conventional and complementary medicine reflects the pluralism in science. Still, a critical issue is the conception of the natural world. Many complementary therapy systems seem to contradict the reductionist-atomistic paradigm that all of natural reality is essentially based on the physical interactions of atoms and molecules. Thus, a fundamental question about the natural world is: Do other than the physical forces exist?</p><p><strong>Summary: </strong>The assumption that no other than physical forces exist and work in the natural world is not tenable. For example, the formation and maintenance of the functional Gestalt of organisms cannot possibly be explained by molecular processes (e.g., from DNA to RNA and further to amino acids and proteins). The processes on each structural level - from molecules, organelles, cells, organs up to the whole organism - are regulated in regard to the formation of the next higher level. Specific Gestalt-forming forces exist and can be systematically investigated. Their existence implies an extended conception of matter. The Gestalt-forming forces and the extended concept of matter may be relevant for the scientific assessment of complementary therapies.</p><p><strong>Key messages: </strong>(i) In the natural world, specific Gestalt-forming forces exist in addition to the physical forces, and can be systematically investigated. (ii) The existence of these forces implies an extended conception of matter. (iii) These forces and this extended concept of matter may be relevant for the scientific assessment of complementary therapies, e.g., homeopathy.</p><p><p><title>Hintergrund</title>In der Integration von konventioneller und komplementärer Medizin spiegelt sich der Methodenpluralismus der Wissenschaft. Die Ontologien vieler komplementärmedizinisches Systeme liegen allerdings außerhalb der Erklärbarkeit durch die Kräfte der Physik. Eine zentrale Frage ist deshalb: Gibt es Kräfte in der Natur, die eine materielle Wirkung haben, deren Ursprung aber nicht in Atomen oder Molekülen und in diesem Sinne nicht in der Materie liegt?<title>Zusammenfassung</title>Die Annahme, dass in der Natur keine anderen als die mit Atomen und Molekülen assoziierten physikalischen Kräfte existent und wirksam seien, ist wissenschaftlich nicht begründet. Beispielsweise ist die Bildung und Erhaltung der funktionsfähigen Gestalt von Organismen nicht durch molekulare Prozesse (z.B. von der DNA zur RNA und weiter zu Aminosäuren und Proteinen) erklärbar. Die Prozesse auf jeder strukturellen Ebene – von den Molekülen, Organellen, Zellen, Organen bis hinauf zum Gesamtorganismus – sind in Hinblick auf die Bildung der funktionsfähigen Gestalt der jeweils nächsthöheren Ebene gesteuert. Für diese Gestaltbildung gibt es spezifische Kräfte, die systematisch erforscht werden können. Ihre Existenz impliziert eine erweiterte Konzeption von Materie. Diese Gestalt-bildenden Kräfte und dieses erweiterte Ko
背景传统医学与补充医学的融合体现了科学的多元化。然而,一个关键问题是自然世界的概念。许多互补的治疗系统似乎与还原主义的原子论范式相矛盾,即所有的自然现实都是以原子和分子的物理相互作用为基础的。因此,关于自然世界的一个基本问题是:除了物理力之外,还存在吗?方法阐述:还原论原子论范式的局限性,生物体内特定格式塔形成力和格式塔维持力的存在,以及对物质概念的启示。结果和结论自然世界中除了物理力之外没有其他力量存在并起作用的假设是不成立的。例如,生物体功能格式塔的形成和维持不可能用分子过程来解释(例如从DNA到RNA,再到氨基酸和蛋白质)。从分子、细胞器、细胞、器官到整个生物体,每个结构层面的过程都受到下一个更高层次的形成的调控。格式塔形成的特定力量是存在的,可以系统地研究。它们的存在意味着对物质的延伸概念。格式塔形成力和物质的扩展概念可能与补充治疗系统的科学评估有关。
{"title":"A Fundamental Question for Complementary Medicine: Are There Other Forces in the Natural World Besides the Physical Forces?","authors":"Helmut Kiene, Harald Johan Hamre","doi":"10.1159/000534592","DOIUrl":"10.1159/000534592","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The integration of conventional and complementary medicine reflects the pluralism in science. Still, a critical issue is the conception of the natural world. Many complementary therapy systems seem to contradict the reductionist-atomistic paradigm that all of natural reality is essentially based on the physical interactions of atoms and molecules. Thus, a fundamental question about the natural world is: Do other than the physical forces exist?&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Summary: &lt;/strong&gt;The assumption that no other than physical forces exist and work in the natural world is not tenable. For example, the formation and maintenance of the functional Gestalt of organisms cannot possibly be explained by molecular processes (e.g., from DNA to RNA and further to amino acids and proteins). The processes on each structural level - from molecules, organelles, cells, organs up to the whole organism - are regulated in regard to the formation of the next higher level. Specific Gestalt-forming forces exist and can be systematically investigated. Their existence implies an extended conception of matter. The Gestalt-forming forces and the extended concept of matter may be relevant for the scientific assessment of complementary therapies.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Key messages: &lt;/strong&gt;(i) In the natural world, specific Gestalt-forming forces exist in addition to the physical forces, and can be systematically investigated. (ii) The existence of these forces implies an extended conception of matter. (iii) These forces and this extended concept of matter may be relevant for the scientific assessment of complementary therapies, e.g., homeopathy.&lt;/p&gt;&lt;p&gt;&lt;p&gt;&lt;title&gt;Hintergrund&lt;/title&gt;In der Integration von konventioneller und komplementärer Medizin spiegelt sich der Methodenpluralismus der Wissenschaft. Die Ontologien vieler komplementärmedizinisches Systeme liegen allerdings außerhalb der Erklärbarkeit durch die Kräfte der Physik. Eine zentrale Frage ist deshalb: Gibt es Kräfte in der Natur, die eine materielle Wirkung haben, deren Ursprung aber nicht in Atomen oder Molekülen und in diesem Sinne nicht in der Materie liegt?&lt;title&gt;Zusammenfassung&lt;/title&gt;Die Annahme, dass in der Natur keine anderen als die mit Atomen und Molekülen assoziierten physikalischen Kräfte existent und wirksam seien, ist wissenschaftlich nicht begründet. Beispielsweise ist die Bildung und Erhaltung der funktionsfähigen Gestalt von Organismen nicht durch molekulare Prozesse (z.B. von der DNA zur RNA und weiter zu Aminosäuren und Proteinen) erklärbar. Die Prozesse auf jeder strukturellen Ebene – von den Molekülen, Organellen, Zellen, Organen bis hinauf zum Gesamtorganismus – sind in Hinblick auf die Bildung der funktionsfähigen Gestalt der jeweils nächsthöheren Ebene gesteuert. Für diese Gestaltbildung gibt es spezifische Kräfte, die systematisch erforscht werden können. Ihre Existenz impliziert eine erweiterte Konzeption von Materie. Diese Gestalt-bildenden Kräfte und dieses erweiterte Ko","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"71-77"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49675144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of Complementary and Alternative Medicine by Patients Treated for Systemic Lupus Erythematosus, Primary Sjögren's Syndrome, or Systemic Sclerosis in a French Rural Region. 法国农村地区接受系统性红斑狼疮、原发性斯约格伦综合征或系统性硬化症治疗的患者使用补充和替代医学的情况。
IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-01-01 Epub Date: 2024-02-12 DOI: 10.1159/000536580
Florence Couillard, Simon Parreau, Stéphanie Dumonteil, Nina Ratti, Sylvain Palat, Holy Bezanahary, Eric Liozon, Kim-Heang Ly, Anne-Laure Fauchais, Guillaume Gondran
<p><strong>Background: </strong>Complementary and alternative medicine (CAM) is composed of a wide range of interventions and frequently used in parallel with conventional medicine. The aim of this study was to assess the prevalence, modalities, and association factors of CAM utilization in patients treated for systemic lupus erythematosus, primary Sjögren's syndrome, or systemic sclerosis.</p><p><strong>Patients and methods: </strong>This was a prospective single-center observational study conducted in a French university hospital center. Inclusion criteria were patients followed for systemic lupus erythematosus, primary Sjögren's syndrome, or systemic sclerosis. Data were collected with a survey which assessed sociodemographic, disease characteristics, CAM use details, life quality, and anxiety score.</p><p><strong>Results: </strong>A total of 121 patients were included, mostly women (87%), with an average age of 56 years. Proportion of patients seeking CAM was 55%. A total of 186 CAM interventions were recorded: most common were osteopathy, homeopathy, and acupuncture. Patients were looking for well-being (22%), reducing their fatigue (18%) and pain (33%). Concerning physical and mental feeling after CAM use, a subjective improvement was reported in 89% of cases. In multivariate analysis, CAM use by patient was associated with these 3 variables: coming from a Western culture, being professionally active, and having a poor quality of life and anxiety scores.</p><p><strong>Conclusion and outlook: </strong>This is the first study to focus on CAM use in patients followed for three AID in a French rural region. The current challenge is to enrich conventional medicine with CAM that is effective and safe through supervised programs to move toward an integrative medicine.</p><p><p><title>Hintergrund</title>Die Komplementär- und Alternativmedizin (CAM) umfasst ein breites Spektrum an Interventionen und wird häufig parallel zur konventionellen Medizin angewendet. Das Ziel dieser Studie war die Beurteilung der Prävalenz, Modalitäten und Assoziationsfaktoren der CAM-Anwendung bei Patienten, die wegen systemischem Lupus erythematodes, primärem Sjögren-Syndrom oder systemischer Sklerose behandelt werden.<title>Patienten und Methoden</title>Es handelte sich um eine prospektive monozentrische Beobachtungsstudie, die an einem französischen Universitätsklinikum durchgeführt wurde. Eingeschlossen wurden Patienten, die dort wegen systemischem Lupus erythematodes, primärem Sjögren-Syndrom oder systemischer Sklerose in Behandlung waren. Die Datenerhebung erfolgte mittels eines Fragebogens, der soziodemografische Merkmale, Krankheitsmerkmale, Einzelheiten der CAM-Anwendung, Lebensqualität- und Angst-Scores umfasste.<title>Ergebnisse</title>Insgesamt wurden 121 Patienten randomisiert, überwiegend Frauen (87%); das Durchschnittsalter betrug 56 Jahre. Der Anteil der Patienten, die CAM wünschten, betrug 55%. Insgesamt 186 CAM-Interventionen wurden erfasst; am häufigsten
背景:补充和替代医学(CAM)由多种干预措施组成,经常与传统医学并行使用。本研究旨在评估系统性红斑狼疮、原发性斯约格伦综合征或系统性硬化症患者使用 CAM 的流行率、方式和相关因素:这是一项在法国一所大学医院中心进行的前瞻性单中心观察研究。纳入标准为系统性红斑狼疮、原发性斯约格伦综合征或系统性硬化症患者。通过调查收集数据,评估社会人口学、疾病特征、使用 CAM 的详情、生活质量和焦虑评分:共纳入 121 名患者,其中大部分为女性(87%),平均年龄为 56 岁。寻求 CAM 的患者比例为 55%。共记录了 186 项 CAM 干预:最常见的是骨疗法、顺势疗法和针灸。患者希望获得健康(22%)、减轻疲劳(18%)和疼痛(33%)。关于使用 CAM 后的身心感受,89% 的病例报告了主观上的改善。在多变量分析中,患者使用 CAM 与以下 3 个变量有关:来自西方文化、从事职业活动、生活质量差和焦虑评分:这是第一项关注法国农村地区三种艾滋病患者使用 CAM 的研究。目前面临的挑战是,如何通过监督计划,用有效、安全的 CAM 来丰富传统医学,向综合医学迈进。
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Complementary Medicine Research
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