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Sociocultural and perinatal health factors associated with Autism spectrum disorder (ASD) in children 与儿童自闭症谱系障碍(ASD)相关的社会文化和围产期健康因素
IF 4.3 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-01-19 DOI: 10.1016/j.comppsych.2025.152576
Phone Myat (Eric) , James Rufus John , Alicia Montgomery , Valsamma Eapen
While previous research has examined perinatal factors in the context of Autism Spectrum Disorder (ASD), studies focusing on sociocultural factors is limited. We conducted a cross-sectional analysis utilizing data from the Australian Autism Biobank (AAB), which encompasses autistic children aged 2–17, their siblings, parents, and unrelated controls. Employing multivariable regression analyses, we aimed to identify factors associated with ASD across various domains, spanning health and lifestyle, perinatal, and postnatal contexts. Importantly, our analyses were adjusted for critical sociodemographic covariates. Advanced maternal age, male sex at birth, and identifying as from culturally and linguistically diverse (CALD) background, were found to be associated with risk of ASD. Pre-existing chronic health conditions in both parents and paternal medication use before conception were also associated with ASD risk in children. Associations with complications during pregnancy, caesarean delivery, and maternal medication use during pregnancy were also found. Postnatal factors of interest included the presence of health conditions (e.g., epilepsy), infections in early-life (e.g., respiratory infections), and atypical development in the first six months of life (e.g., hypotonia). These insights can guide closer monitoring and support for those with pre-existing vulnerabilities especially in terms of certain perinatal and sociocultural characteristics.
虽然以前的研究已经检查了自闭症谱系障碍(ASD)背景下的围产期因素,但关注社会文化因素的研究有限。我们利用澳大利亚自闭症生物银行(AAB)的数据进行了横断面分析,其中包括2-17岁的自闭症儿童、他们的兄弟姐妹、父母和不相关的对照组。采用多变量回归分析,我们旨在确定与ASD相关的各个领域的因素,包括健康和生活方式、围产期和产后环境。重要的是,我们的分析针对关键的社会人口协变量进行了调整。研究发现,高龄产妇、出生时为男性以及来自文化和语言多样性(CALD)背景与自闭症谱系障碍的风险相关。父母双方已有的慢性健康状况和父亲在怀孕前使用药物也与儿童患自闭症的风险有关。还发现与妊娠期并发症、剖腹产和孕妇妊娠期用药有关。值得关注的产后因素包括健康状况(如癫痫)、生命早期感染(如呼吸道感染)和生命前6个月的非典型发育(如张力低下)。这些见解可以指导更密切地监测和支持那些预先存在脆弱性的人,特别是在某些围产期和社会文化特征方面。
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引用次数: 0
Hikikomori (prolonged social withdrawal) and co-occurring psychiatric disorders and symptoms in adolescents and young adults: A scoping review 青少年和年轻人中“隐蔽青年”(长时间社交退缩)和共同发生的精神疾病和症状:范围综述
IF 4.3 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-01-09 DOI: 10.1016/j.comppsych.2024.152573
Virginia Pupi , Cinzia Bressi , Paola Maria Porcelli , Maria Gloria Rossetti , Marcella Bellani , Antonio Trabacca , Paolo Brambilla , Antonella Delle Fave , the SOLITAIRE group

Background

Hikikomori, or prolonged social withdrawal, is a clinical condition usually emerging during adolescence or young adulthood, characterized by severe self-isolation in one's home, and often associated with other psychiatric disorders and symptoms.

Objective

The study summarized evidence of hikikomori diagnostic criteria, clinical manifestations, and comorbidity with psychiatric disorders and symptoms in adolescents and young adults.

Methods

A scoping review was conducted following PRISMA guidelines, with four electronic databases searched for original works in English, French, and Italian published since 2010.

Results

A total of 15 studies were selected, 7 involved adolescents, 4 young adults, and 4 participants from both age groups. Most studies relied on the diagnostic criteria proposed for hikikomori inclusion in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Differences in hikikomori and comorbidity profiles were identified between adolescents and young adults.

Conclusions

Heterogeneity characterized hikikomori diagnostic criteria, comorbidity, demographic and clinical features of the study samples. Studies adopting more homogeneous populations, shared diagnostic criteria, consistent assessment tools and longitudinal designs are needed to better clarify the clinical features of hikikomori in young people.
背景:“隐蔽青年”(Hikikomori),或称长时间社交退缩,是一种通常出现在青春期或青年期的临床状况,其特征是在家中严重自我隔离,通常伴有其他精神疾病和症状。目的:总结青少年和青壮年中“隐蔽青年”的诊断标准、临床表现以及与精神疾病和症状的合并症。方法:根据PRISMA指南进行范围综述,检索自2010年以来出版的英语、法语和意大利语的四个电子数据库。结果:共选取了15项研究,其中7项涉及青少年,4项涉及青壮年,两个年龄组各有4名参与者。大多数研究依赖于第五版《精神疾病诊断与统计手册》(DSM-5)中提出的“隐蔽青年”诊断标准。青少年和青壮年在隐蔽青年和合并症方面存在差异。结论:研究样本中隐蔽青年的诊断标准、合并症、人口学和临床特征具有异质性。研究需要采用更均匀的人群、共同的诊断标准、一致的评估工具和纵向设计,以更好地阐明年轻人“隐蔽青年”的临床特征。
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引用次数: 0
Adequacy of treatment in outpatients with obsessive-compulsive disorder 强迫症门诊患者治疗的充分性。
IF 4.3 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-11-17 DOI: 10.1016/j.comppsych.2024.152546
S.E. Cohen , B.W. Storosum , N.C. Vulink , P.P. De Koning , Y. Namavar , J.B. Zantvoord , D. Denys

Objective

To examine whether patients with obsessive-compulsive disorder (OCD) are adequately treated with pharmacotherapy before referral to a specialized center for OCD.

Methods

We performed a retrospective chart review of patients with OCD who were seen for intake at an academic outpatient center in The Netherlands between 2016 and 2023. We collected data on age, gender, illness severity using the Yale-Brown Obsessive-Compulsive Scale, duration of illness, comorbidity and past pharmacotherapy and psychotherapy. Following the international treatment guidelines, we calculated percentages of patients treated with one SSRI, two or more SSRIs, clomipramine and/or antipsychotic augmentation treatments. Using multiple regression, we analyzed if patient and illness characteristics influenced the adequacy of treatment.

Results

We included 673 patients with an average YBOCS score of 27. 76 % had taken at least one SSRI, and 35 % at least two SSRIs before admission. Only 29 % received a high SSRI-dose and 4 % had taken at least two SSRIs in high dose. Clomipramine and antipsychotics augmentation had been taken by less than one-third of patients. Only 3 % of referred patients followed all guideline-recommended treatment steps. Although the vast majority of patients had received some form of psychotherapy, a minority had received exposure and response prevention treatment. Multiple regression showed that illness duration and having received psychotherapy were independent moderators of the adequacy of pharmacological treatment.

Conclusion

Patients with OCD are not being treated adequately according to the pharmacological guidelines. Poor pharmacological treatment may lead to increased duration of illness, suboptimal recovery and unnecessary societal costs. Further research could clarify barriers for patients and caregivers, and facilitate improvement of pharmacological treatment for OCS.
摘要研究强迫症(OCD)患者在转诊至强迫症专科中心之前是否接受了充分的药物治疗:我们对2016年至2023年间在荷兰一家学术门诊中心就诊的强迫症患者进行了回顾性病历审查。我们使用耶鲁-布朗强迫症量表(Yale-Brown Obsessive-Compulsive Scale)收集了患者的年龄、性别、病情严重程度、病程、合并症、既往药物治疗和心理治疗等数据。根据国际治疗指南,我们计算了接受一种 SSRI、两种或两种以上 SSRI、氯米帕明和/或抗精神病药物增强治疗的患者百分比。我们使用多元回归法分析了患者和疾病特征是否会影响治疗的充分性:入院前,76%的患者至少服用过一种SSRI,35%的患者至少服用过两种SSRI。只有 29% 的患者服用过大剂量的 SSRI,4% 的患者至少服用过两种大剂量的 SSRI。服用氯米帕明和抗精神病药物的患者不到三分之一。只有 3% 的转诊患者遵循了指南建议的所有治疗步骤。虽然绝大多数患者都接受过某种形式的心理治疗,但只有少数患者接受过暴露和反应预防治疗。多元回归显示,病程长短和是否接受过心理治疗是药物治疗是否充分的独立调节因素:结论:强迫症患者并没有按照药物治疗指南得到充分治疗。药物治疗不当可能会导致病程延长、康复效果不理想以及不必要的社会成本。进一步的研究可以澄清患者和护理人员面临的障碍,促进改善对强迫症的药物治疗。
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引用次数: 0
A comparison of firefighter mental health education programs: A descriptive thematic analysis of firefighter experiences 消防员心理健康教育计划比较:对消防员经历的描述性专题分析。
IF 4.3 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-11-16 DOI: 10.1016/j.comppsych.2024.152547
Sara M. Stretton , Joy C. MacDermid , Margaret Lomotan , Shannon C. Killip

Background

In response to the inherent critical incident exposures experienced by firefighters, various mental health education programs have been developed. The purpose of this study was to explore the perceptions of firefighters who took such programs to understand differences/similarities across these programs.

Methods

We recruited 14 participants, who had taken or delivered two or more programs for firefighters (Resilient Minds (RM), Road to Mental Readiness (R2MR), and Before Operational Stress (BOS)). Participants participated in semi-structured interviews, which explored information that they learned, recalled, used, and their preferences. Data was analysed using thematic analysis.

Results

Participants believed that all programs had some shared teaching methods, goals, skills, and topics; however, each program had key focuses/distinctive features. RM was said to be largely group participation and focused on assisting yourself, peers, and citizens. R2MR and BOS was said to be largely lecture style with a focus on the self. 70 % of participants who took RM (n = 7) and one other course preferred RM due to the specificity of training to firefighters, more active teaching methods, and focus on practical skill development. Others (43 %) had no program preference. Participants suggest that a tiered approach to mental health education would benefit firefighters.

Conclusions

All programs were seen as helpful. Despite some congruency in goals and content, most firefighters preferred RM because the content was fire-specific, and the pedagogical approach was seen as more active and engaging. Program characteristics are important to facilitate appropriate program selection, as such, programs should be explicit about these aspects.
背景:为了应对消防员固有的突发事件风险,人们开发了各种心理健康教育计划。本研究旨在探讨参加过此类项目的消防员的看法,以了解这些项目之间的差异/相似之处:我们招募了 14 名参加者,他们参加过或提供过两个或两个以上的消防员项目(Resilient Minds (RM)、Road to Mental Readiness (R2MR) 和 Before Operational Stress (BOS))。参与者参加了半结构式访谈,访谈内容包括他们学到的、回忆起的、使用过的信息以及他们的偏好。采用主题分析法对数据进行了分析:结果:参与者认为,所有项目都有一些共同的教学方法、目标、技能和主题;但是,每个项目都有重点/独特之处。据说,RM 主要是集体参与,侧重于帮助自己、同伴和公民。据说,R2MR 和 BOS 主要是讲座式的,侧重于自我。70% 参加过 RM(n = 7)和一门其他课程的学员更喜欢 RM,因为它针对消防员的培训更具体,教学方法更活跃,而且注重实际技能的培养。其他学员(43%)对课程没有偏好。学员们建议,采用分层方法开展心理健康教育将使消防员受益匪浅:结论:所有项目都被认为是有益的。尽管在目标和内容上有一些相同之处,但大多数消防员更喜欢 RM,因为其内容是针对消防工作的,而且教学方法被认为更积极、更吸引人。项目的特点对于促进适当的项目选择非常重要,因此,项目应明确这些方面。
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引用次数: 0
Acceptability, tolerability and safety of the BRIGhTMIND trial: Connectivity-guided intermittent theta-burst stimulation versus F3- repetitive transcranial magnetic stimulation for treatment-resistant depression BRIGhTMIND 试验的可接受性、耐受性和安全性:连接引导的间歇θ-脉冲刺激与 F3-重复经颅磁刺激治疗耐药抑郁症的对比
IF 4.3 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-11-04 DOI: 10.1016/j.comppsych.2024.152544
Lucy Webster , Clement Boutry , Louise Thomson , Mohamed Abdelghani , Shaun Barber , Paul M. Briley , Micheal Kurkar , Sudheer Lankappa , R. Hamish McAllister-Williams , Ana Suazo Di Paola , Richard Morriss , BRIGhTMIND study and LEAP team

Background

The BRIGhTMIND study was a double-blind RCT comparing repetitive transcranial magnetic stimulation at a standard simulation site (the “F3” location given by the International 10–20 system, F3-rTMS) versus connectivity-guided intermittent theta burst stimulation (cgiTBS) for treatment-resistant depression. This present study reports the acceptability, safety, and tolerability of F3-rTMS versus cgiTBS.

Methods

The present study used quantitative and qualitative methods. Two hundred fifty-four participants were included in the quantitative BRIGhTMIND acceptability and safety analysis (n = 126 F3-rTMS, n = 128 cgiTBS). Qualitative analysis included interviews for 15 participants (n = 7 F3-rTMS, n = 8 cgiTBS) and 582 written comments made by any participant randomised to the BRIGhTMIND trial regarding their experience of TMS and the study. Statistical analyses were used to explore differences between F3-rTMS and cgiTBS, as well as associations between acceptability, impression of change and safety. Qualitative data was analysed using an inductive thematic framework approach.

Outcomes

Acceptability, TMS benefits/negative effects and impression of improvement ratings did not differ across the two treatment protocols, with ratings maintained long-term (71.4 % rated TMS acceptable, 48.8 % indicated benefits of TMS outweighed negative effects and 52.2 % feeling somewhat or much better at 26 week follow-up n = 203). Impression of improvement was positively associated with acceptability and TMS benefits. Qualitative themes included participants' TMS experience, TMS response variability, and lay theories of effectiveness. Safety profiles were comparable between F3-rTMS and cgiTBS, with 74.5 % of participants (n = 190/254) experiencing at least one adverse event possibly, probably, or definitely related to TMS. The majority of adverse events were transient and mild, with a sizeable number requiring simple treatments or small adjustments to TMS intensity and coil positioning. The F3-rTMS group had a significantly greater proportion of participants that required small adjustments to TMS to tolerate treatment compared to the cgiTBS group. Serious adverse events were rare, with one serious event in each treatment arm possibly related to TMS (F3-rTMS- psychotic episode, cgiTBS-manic episode).

Conclusion

F3-rTMS and cgiTBS are comparably safe, tolerable and highly acceptable interventions for treatment-resistant depression. BRIGhTMIND systematically collected data from a large sample, providing evidence to meet the information needs of patients, clinicians and policy makers.
背景BRIGhTMIND研究是一项双盲RCT研究,比较了在标准模拟部位(国际10-20系统给出的 "F3 "位置,即F3-rTMS)重复经颅磁刺激与连接引导间歇θ脉冲刺激(cgiTBS)治疗耐药抑郁症的效果。本研究报告了 F3-rTMS 与 cgiTBS 的可接受性、安全性和耐受性。254 名参与者被纳入 BRIGhTMIND 可接受性和安全性定量分析(n = 126 F3-rTMS,n = 128 cgiTBS)。定性分析包括对 15 名参与者(n = 7 名 F3-rTMS,n = 8 名 cgiTBS)的访谈,以及 582 份由任何随机参加 BRIGhTMIND 试验的参与者就其 TMS 体验和研究发表的书面意见。统计分析用于探讨 F3-rTMS 和 cgiTBS 之间的差异,以及可接受性、变化印象和安全性之间的关联。结果两种治疗方案的可接受性、TMS的益处/负面影响和改善印象评分没有差异,并且评分长期保持不变(71.4%的人认为TMS是可接受的,48.8%的人表示TMS的益处大于负面影响,52.2%的人在26周的随访中感觉有所好转或好转很多,n = 203)。改善印象与可接受性和 TMS 的益处呈正相关。定性主题包括参与者的 TMS 体验、TMS 反应变异性和非专业的有效性理论。F3-rTMS 和 cgiTBS 的安全性相当,74.5% 的参与者(n = 190/254)至少经历过一次可能、大概或肯定与 TMS 有关的不良事件。大多数不良事件都是短暂和轻微的,其中相当一部分需要简单治疗或对 TMS 强度和线圈位置进行小幅调整。与 cgiTBS 组相比,F3-rTMS 组需要对 TMS 进行小幅调整才能耐受治疗的参与者比例明显更高。结论F3-rTMS和cgiTBS是治疗耐药性抑郁症的安全性、耐受性和可接受性相当高的干预方法。BRIGhTMIND 系统地收集了大量样本数据,为满足患者、临床医生和政策制定者的信息需求提供了证据。
{"title":"Acceptability, tolerability and safety of the BRIGhTMIND trial: Connectivity-guided intermittent theta-burst stimulation versus F3- repetitive transcranial magnetic stimulation for treatment-resistant depression","authors":"Lucy Webster ,&nbsp;Clement Boutry ,&nbsp;Louise Thomson ,&nbsp;Mohamed Abdelghani ,&nbsp;Shaun Barber ,&nbsp;Paul M. Briley ,&nbsp;Micheal Kurkar ,&nbsp;Sudheer Lankappa ,&nbsp;R. Hamish McAllister-Williams ,&nbsp;Ana Suazo Di Paola ,&nbsp;Richard Morriss ,&nbsp;BRIGhTMIND study and LEAP team","doi":"10.1016/j.comppsych.2024.152544","DOIUrl":"10.1016/j.comppsych.2024.152544","url":null,"abstract":"<div><h3>Background</h3><div>The BRIGhTMIND study was a double-blind RCT comparing repetitive transcranial magnetic stimulation at a standard simulation site (the “F3” location given by the International 10–20 system, F3-rTMS) versus connectivity-guided intermittent theta burst stimulation (cgiTBS) for treatment-resistant depression. This present study reports the acceptability, safety, and tolerability of F3-rTMS versus cgiTBS.</div></div><div><h3>Methods</h3><div>The present study used quantitative and qualitative methods. Two hundred fifty-four participants were included in the quantitative BRIGhTMIND acceptability and safety analysis (<em>n</em> = 126 F3-rTMS, <em>n</em> = 128 cgiTBS). Qualitative analysis included interviews for 15 participants (<em>n</em> = 7 F3-rTMS, <em>n</em> = 8 cgiTBS) and 582 written comments made by any participant randomised to the BRIGhTMIND trial regarding their experience of TMS and the study. Statistical analyses were used to explore differences between F3-rTMS and cgiTBS, as well as associations between acceptability, impression of change and safety. Qualitative data was analysed using an inductive thematic framework approach.</div></div><div><h3>Outcomes</h3><div>Acceptability, TMS benefits/negative effects and impression of improvement ratings did not differ across the two treatment protocols, with ratings maintained long-term (71.4 % rated TMS acceptable, 48.8 % indicated benefits of TMS outweighed negative effects and 52.2 % feeling somewhat or much better at 26 week follow-up <em>n</em> = 203). Impression of improvement was positively associated with acceptability and TMS benefits. Qualitative themes included participants' TMS experience, TMS response variability, and lay theories of effectiveness. Safety profiles were comparable between F3-rTMS and cgiTBS, with 74.5 % of participants (<em>n</em> = 190/254) experiencing at least one adverse event possibly, probably, or definitely related to TMS. The majority of adverse events were transient and mild, with a sizeable number requiring simple treatments or small adjustments to TMS intensity and coil positioning. The F3-rTMS group had a significantly greater proportion of participants that required small adjustments to TMS to tolerate treatment compared to the cgiTBS group. Serious adverse events were rare, with one serious event in each treatment arm possibly related to TMS (F3-rTMS- psychotic episode, cgiTBS-manic episode).</div></div><div><h3>Conclusion</h3><div>F3-rTMS and cgiTBS are comparably safe, tolerable and highly acceptable interventions for treatment-resistant depression. BRIGhTMIND systematically collected data from a large sample, providing evidence to meet the information needs of patients, clinicians and policy makers.</div></div>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"136 ","pages":"Article 152544"},"PeriodicalIF":4.3,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exercise moderates longitudinal group psychopathology networks in individuals with eating disorders 运动可调节饮食失调症患者的纵向群体心理病理学网络。
IF 4.3 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-11-03 DOI: 10.1016/j.comppsych.2024.152543
David R. Kolar , Christina Ralph-Nearman , Trevor Swanson , Cheri A. Levinson
Individuals with eating disorders (EDs) often engage in exercise no matter potential negative long-term outcomes (e.g., weight loss, injury). Yet exercising may temporarily attenuate ED symptoms, but whether exercise also affects network structure and pairwise associations of ED symptoms remained unclear. We used a novel approach called Moderated Multilevel Graphical Vector Autoregression to estimate changes in psychopathology networks from before to after exercising in ecological momentary assessment data from 102 individuals with EDs across multiple days (M = 22.14, SD = 5.40; range: 6–22 days) at 4 times daily. Between-person and within-person temporal networks were computed, obtaining stable centrality coefficients for temporal networks only. In those, autoregressive effects of several symptoms, including binge-eating, overeating, or weighing oneself, were attenuated when participants previously exercised. Exercise mostly downregulated temporal effects of ED symptoms on other symptoms, including effects of binge eating and other compensatory behaviors on feeling guilty after the most recent meal, vomiting on weighing oneself, and overeating on fear of weight gain. Our study highlights the complex dynamic effects of exercise on ED symptoms in daily life and calls for novel studies investigating mechanisms of exercise to inform treatments targeting detrimental long-term effects of exercise in EDs.
患有饮食失调症(ED)的人经常参加锻炼,不管可能产生的长期负面结果(如体重减轻、受伤)如何。然而,运动可能会暂时减轻进食障碍症状,但运动是否也会影响进食障碍症状的网络结构和配对关联仍不清楚。我们采用了一种名为 "调节多层次图形向量自回归 "的新方法,从102名ED患者的生态瞬间评估数据中估算出运动前到运动后精神病理学网络的变化,这些数据来自多天(中=22.14,标差=5.40;范围:6-22天),每天运动4次。计算了人与人之间和人与人之间的时间网络,仅在时间网络中获得了稳定的中心系数。在这些网络中,当参与者之前进行过运动时,包括暴饮暴食、暴饮暴食或自重在内的几种症状的自回归效应都会减弱。运动在很大程度上降低了 ED 症状对其他症状的时间效应,包括暴饮暴食和其他补偿行为对最近一次进餐后内疚感的影响、呕吐对称量体重的影响以及暴饮暴食对担心体重增加的影响。我们的研究强调了运动对日常生活中 ED 症状的复杂动态影响,并呼吁对运动机制进行新的研究,为针对运动对 ED 的长期不利影响的治疗提供依据。
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引用次数: 0
The deer mouse (Peromyscus maniculatus bairdii) as a model organism to explore the naturalistic psychobiological mechanisms contributing to compulsive-like rigidity: A narrative overview of advances and opportunities 以鹿鼠(Peromyscus maniculatus bairdii)为模式生物,探索导致强迫性僵化的自然心理生物学机制:进展与机遇综述。
IF 4.3 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-11-02 DOI: 10.1016/j.comppsych.2024.152545
Vasti Theron , Chrstine Lochner , Dan J. Stein , Brian H Harvey , De Wet Wolmarans
Deer mice (Peromyscus maniculatus bairdii), a wildtype species native to North America, have been investigated for their spontaneous compulsive-like behaviour. The repetitive and persistence nature of three unique compulsive-like phenotypes in deer mice, i.e., high stereotypy (HS), large nesting behaviour (LNB) and high marble burying (HMB), are characterized by behavioural and cognitive rigidity. In this narrative review, we summarize key advances in the model's application to study obsessive-compulsive disorder (OCD), emphasizing how it may be used to investigate neurobiological and neurocognitive aspects of rigidity. Indeed, deer mice provide the field with a unique naturalistic and spontaneous model system of behavioural and cognitive rigidity that is useful for investigating the psychobiological mechanisms that underpin a range of compulsive-like phenotypes. Throughout the review, we highlight new opportunities for future research.
鹿小鼠(Peromyscus maniculatus bairdii)是一种原产于北美洲的野生型物种,其自发性强迫行为已被研究过。鹿小鼠有三种独特的强迫行为表型,即高度刻板行为(HS)、大型筑巢行为(LNB)和高度大理石埋藏行为(HMB),其重复性和持续性的特点是行为和认知僵化。在这篇叙述性综述中,我们总结了将该模型应用于研究强迫症(OCD)的主要进展,强调了如何利用该模型来研究僵化的神经生物学和神经认知方面。事实上,鹿小鼠为该领域提供了一个独特的自然和自发的行为和认知僵化模型系统,有助于研究支撑一系列强迫症表型的心理生物学机制。在整篇综述中,我们强调了未来研究的新机遇。
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引用次数: 0
Identifying factors strongest associated with clinical, societal and personal recovery in people with psychosis with a long duration of illness 确定与病程较长的精神病患者的临床、社会和个人康复最密切相关的因素。
IF 4.3 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-28 DOI: 10.1016/j.comppsych.2024.152540
Stynke Castelein , Ellen Visser , PHAMOUS-investigators , Maarten F. Brilman , Klaas J. Wardenaar , Jojanneke Bruins

Introduction

Most studies on recovery of psychotic disorders focus on first-episode populations using premorbid and baseline data to predict recovery. However, many patients experience a long duration of illness and many factors are dynamic and change during life.

Aims

To investigate factors strongest associated with clinical, societal and personal recovery, and recovery change scores in people with a long duration of illness using current data measured at the same assessment.

Methods

Least absolute shrinkage and selection operator regression analyses with cross-validation were used to identify the correlates of (changes in) clinical (N = 1054), societal (N = 1145) and personal recovery (N = 1187) in people with psychotic disorders. Subsequently, the identified associated factors were included in separate linear regression models, examining the associative strength of the identified variables and overall fit of the models.

Results

Better clinical recovery was associated with better societal and personal recovery, experiencing fewer problems with daily functioning and social relations. Participants had a better societal recovery when they were employed, had fewer problems in daily life, less negative symptoms, had a life partner and better clinical recovery. Personal recovery was associated with greater satisfaction with life in general, no depressive mood and increased clinical recovery. Change scores were small with minimal fluctuation and no significant associations with change scores were detected.

Conclusions

Recovery domains strongly influence each other in people with a long illness duration of psychosis and should therefore have an equally important focus during treatment.
导言:大多数有关精神病康复的研究都集中在首次发病的人群中,使用发病前和基线数据来预测康复情况。然而,许多患者的病程较长,而且许多因素是动态的,在生活中会发生变化。目的:利用在同一次评估中测量的当前数据,研究与病程较长患者的临床、社会和个人康复以及康复变化评分最密切相关的因素:方法:使用最小绝对缩减和选择算子回归分析以及交叉验证来确定精神病患者临床(1054 人)、社会(1145 人)和个人康复(1187 人)(变化)的相关因素。随后,将确定的相关因素纳入单独的线性回归模型,检查确定变量的关联强度和模型的总体拟合度:结果:较好的临床康复与较好的社会和个人康复相关,在日常功能和社会关系方面遇到的问题较少。如果参与者有工作、日常生活中遇到的问题较少、负面症状较少、有生活伴侣且临床康复情况较好,则社会康复情况较好。个人康复与总体生活满意度提高、无抑郁情绪和临床康复程度提高有关。变化分值较小,波动也很小,没有发现与变化分值有显著关联:结论:对于病程较长的精神病患者来说,康复的各个领域相互影响,因此在治疗过程中应同等重视。
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引用次数: 0
Correlates of risk-taking behaviour and suicidality among humanitarian aid workers 人道主义援助工作者冒险行为和自杀倾向的相关因素。
IF 4.3 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-28 DOI: 10.1016/j.comppsych.2024.152541
Frédérique Vallières , Hamed Seddighi , Áine Travers , Peter Varah , Nana Wiedemann , Cecilie Dinesen , Kinan Aldamman , James Lee , Bonnix Kayabu , Philip Hyland
In an era of high need for humanitarian assistance, humanitarian aid workers face increased exposure to potentially traumatic events and, correspondingly, a greater risk of psychological distress (e.g., anxiety, depression, posttraumatic stress disorder [PTSD], and burnout). Less studied among humanitarian workers, however, are other known correlates of trauma-exposure: complex PTSD, risk-taking behaviours, and suicidality. The current study examined levels of trauma exposure and rates of trauma-related mental health disorders, risk-taking behaviour, and levels of suicidality among a sample (N = 232) of humanitarian workers located across 52 countries. Multiple linear regression analysis was used to determine which demographic (i.e., sex, age, cadre, years working as an aid worker), psychological (i.e., social support, personality traits), and trauma-related (trauma exposure, complex posttraumatic stress disorder [CPTSD] symptoms, and dissociation) variables were uniquely associated with risk-taking behaviours and suicidality. Overall, 12.9 % (95 % CI = 8.5 %, 17.2 %) of humanitarian workers met the diagnostic requirements for PTSD, and 8.6 % (95 % CI = 5.0 %, 12.2 %) met requirements for CPTSD. Higher risk-taking behaviours were significantly associated with being male, an international worker, greater trauma exposure, extraversion, neuroticism, and CPTSD symptoms. Suicidality was significantly associated with being an international staff member and higher levels of dissociation. Results are consistent with previous studies citing a high risk of psychological distress among humanitarian workers. Humanitarian aid agencies have a duty of care to their workers - both professional and volunteer - and greater safeguarding measures are necessary to mitigate the risk to mental health brought on by humanitarian work-related stressors.
在人道主义援助需求高涨的时代,人道主义援助工作者面临着更多潜在创伤事件的风险,相应地,也面临着更大的心理困扰风险(如焦虑、抑郁、创伤后应激障碍(PTSD)和职业倦怠)。然而,在人道主义工作者中,对创伤暴露的其他已知相关因素研究较少:复杂创伤后应激障碍、冒险行为和自杀倾向。本研究调查了位于 52 个国家的人道主义工作者样本(样本数 = 232)中的创伤暴露程度、与创伤相关的心理健康疾病发病率、冒险行为和自杀程度。我们采用多元线性回归分析来确定哪些人口统计学变量(即性别、年龄、干部、援助工作者工作年限)、心理学变量(即社会支持、人格特质)和创伤相关变量(创伤暴露、复杂创伤后应激障碍 [CPTSD] 症状和分离)与冒险行为和自杀倾向有独特的关联。总体而言,12.9%(95% CI = 8.5%,17.2%)的人道主义工作者符合创伤后应激障碍的诊断要求,8.6%(95% CI = 5.0%,12.2%)符合复杂创伤后应激障碍的诊断要求。较高的冒险行为与男性、国际工作人员、较多的创伤暴露、外向性、神经质和 CPTSD 症状有显著关联。自杀行为与国际工作人员身份和较高的解离程度有很大关系。这些研究结果与之前的研究结果一致,即人道救援人员面临着较高的心理压力风险。人道主义援助机构有责任照顾其工作人员(包括专业人员和志愿者),因此有必要采取更多的保障措施,以降低与人道主义工作相关的压力给心理健康带来的风险。
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引用次数: 0
The prospective associations between problematic gaming and phubbing among Chinese adolescents: Insights from a cross-lagged panel network model 中国青少年问题游戏与嗜睡之间的前瞻性关联:跨滞后面板网络模型的启示。
IF 4.3 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-25 DOI: 10.1016/j.comppsych.2024.152542
Yingying Su , Yan Chen , Qian Gai , Xiangfei Meng , Tingting Gao

Background and aims

Previous studies are limited in addressing the directionality of temporal relationships between problematic gaming and phubbing symptoms by exploring cross-sectional studies. Therefore, we estimated the longitudinal relationships between individual behavioral addictive symptoms including problematic gaming and phubbing in adolescence, and explored potential sex differences in these relationships.

Methods

This study included 3296 participants in Shandong Province, China. Data were collected from November 2021 (mean [SD] age: 15.17 [1.44] years) to May 2023 (mean [SD] age: 17.50 [1.18] years), with females comprising 54.5 % of the sample. Problematic gaming and phubbing were assessed using validated scales at each wave. We construct cross-sectional networks and cross-lagged panel networks (CLPN) to explore the contemptuous and temporal relationships between problematic gaming and phubbing.

Results

Contemporaneous networks revealed significant differences in problematic gaming and phubbing networks between males and females. Additionally, temporal network analyses indicated that among male adolescents, feeling anxious when unable to play games was the most influential predictor of subsequent behavioral addictive symptoms. For female adolescents, fantasizing about gaming had the most significant associations with future addictive behaviors. The strongest bridge symptom linking problematic gaming and phubbing for both sexes was focusing on phones rather than engaging in conversation.

Discussion and conclusions

The study applied network modeling to panel data from a large, population-based cohort of adolescents, identifying unique longitudinal relationships between problematic gaming and phubbing across symptom domains. It provides valuable insights into the characterization of behavioral addictive symptoms among adolescents and the potential predictive relationships among these symptoms among different sexes, guiding sex-specific targeted interventions for adolescents.
背景和目的:以往的研究局限于通过横断面研究来探讨问题游戏和嗜睡症状之间时间关系的方向性。因此,我们估计了青春期包括问题游戏和嗜睡在内的个体行为成瘾症状之间的纵向关系,并探讨了这些关系中潜在的性别差异:本研究纳入了中国山东省的 3296 名参与者。数据收集时间为 2021 年 11 月(平均 [SD] 年龄:15.17 [1.44] 岁)至 2023 年 5 月(平均 [SD] 年龄:17.50 [1.18] 岁),其中女性占样本的 54.5%。每次调查都使用经过验证的量表对有问题的游戏和网络游戏进行评估。我们构建了横截面网络和跨滞后面板网络(CLPN),以探讨问题游戏和幽会之间的蔑视和时间关系:结果:同期网络显示,男性和女性之间的问题游戏和泡吧网络存在显著差异。此外,时间网络分析显示,在男性青少年中,无法玩游戏时的焦虑感是对随后行为成瘾症状最有影响力的预测因素。对于女性青少年来说,对游戏的幻想与未来成瘾行为的关联最为显著。对于男女青少年来说,将问题游戏和嗜睡联系起来的最强烈的桥梁症状是专注于手机而不是进行交谈:该研究将网络建模应用于一个大型的、以人群为基础的青少年队列的面板数据中,发现了问题游戏和嗜睡之间在症状领域的独特纵向关系。该研究对青少年行为成瘾症状的特征以及这些症状在不同性别间的潜在预测关系提供了有价值的见解,从而为针对不同性别青少年的针对性干预措施提供指导。
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引用次数: 0
期刊
Comprehensive psychiatry
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