K. Yıldız, S. K. Uzunçakmak, Z. Halıcı, C. Özçelik, A. Yazici
Sedentary life brings risks that include osteoporosis, while physical activity has many benefits for health in general and the skeletal system. Irisin is a hormone-like myokine regulated by mechanical force and it contributes to cortical and trabecular bone mineral density. This study aimed to investigate the effects of different types of sports on bone health by measuring elite athletes’ fibronectin type III domain 5 (FNDC5), N-terminal collagen type I extension propeptide (PINP), and C-terminal cross-linking telopeptide of type I collagen (CTXI) levels. Combat sports athletes, team sports athletes, and sedentary control subjects were enrolled. Serum levels of proteins were measured by ELISA. FNDC5 levels of elite athletes were higher compared to the sedentary controls (P=0.0014). The highest FNDC5 level was measured in wrestlers among all considered groups. The PINP levels of the athletes were also higher than those of the sedentary control group (P=0.1431). The highest PINP level was determined in boxers. The CTXI levels of the athletes were lower than those of the sedentary control (P<0.0001). The lowest CTXI level was seen in boxers. The FNDC5 and PINP levels of combat sports athletes were higher than those of team sports athletes (P=0.0134 and P=0.0262, respectively), while the CTXI levels of combat sports athletes were lower than those of team sports athletes (P<0.0001). Our results indicated that FNDC5, PINP, and CTXI levels are associated with physical activity. The effect of the exercises performed by athletes of specific sports on bone health has not been studied in much detail before. Combining different exercises for athletes of a particular sport may be more beneficial for bone health.
{"title":"A comparison of the associations between bone turnover markers and different sports fields: combat versus team sports","authors":"K. Yıldız, S. K. Uzunçakmak, Z. Halıcı, C. Özçelik, A. Yazici","doi":"10.3920/cep220047","DOIUrl":"https://doi.org/10.3920/cep220047","url":null,"abstract":"Sedentary life brings risks that include osteoporosis, while physical activity has many benefits for health in general and the skeletal system. Irisin is a hormone-like myokine regulated by mechanical force and it contributes to cortical and trabecular bone mineral density. This study aimed to investigate the effects of different types of sports on bone health by measuring elite athletes’ fibronectin type III domain 5 (FNDC5), N-terminal collagen type I extension propeptide (PINP), and C-terminal cross-linking telopeptide of type I collagen (CTXI) levels. Combat sports athletes, team sports athletes, and sedentary control subjects were enrolled. Serum levels of proteins were measured by ELISA. FNDC5 levels of elite athletes were higher compared to the sedentary controls (P=0.0014). The highest FNDC5 level was measured in wrestlers among all considered groups. The PINP levels of the athletes were also higher than those of the sedentary control group (P=0.1431). The highest PINP level was determined in boxers. The CTXI levels of the athletes were lower than those of the sedentary control (P<0.0001). The lowest CTXI level was seen in boxers. The FNDC5 and PINP levels of combat sports athletes were higher than those of team sports athletes (P=0.0134 and P=0.0262, respectively), while the CTXI levels of combat sports athletes were lower than those of team sports athletes (P<0.0001). Our results indicated that FNDC5, PINP, and CTXI levels are associated with physical activity. The effect of the exercises performed by athletes of specific sports on bone health has not been studied in much detail before. Combining different exercises for athletes of a particular sport may be more beneficial for bone health.","PeriodicalId":10709,"journal":{"name":"Comparative Exercise Physiology","volume":"1 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90909805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Exercise-induced muscle damage (EIMD) and repeated bout effect (RBE) are widely researched across various populations. EIMD is the muscle damage occurring after one bout of unaccustomed exercise while RBE is the attenuation of the same muscle damage in subsequent second bout. RBE seems to have significant implications for exercise prescription. Despite existence of vast literature, there is lack of clarity on the effects of EIMD and RBE in a healthy population. The purpose of this study is to review the literature on EIMD and RBE in healthy participants published during the last 10 years. The search of major databases (including Scopus, Google Scholar and PubMed) was conducted using specific keywords ‘Exercise induced muscle damage’, ‘Repeated bout effect’, ‘Healthy participants’ ‘Pre-conditioning’, ‘Eccentric exercise’. Studies published from 2011 onwards which included EIMD and RBE assessment in healthy participants were included in this review. Database searching revealed a total of 38 studies on EIMD and RBE in healthy participants. Three major themes of papers were identified that focused on EIMD and RBE along with (1) age related differences, (2) sex-based differences, and (3) response in athletes. Findings of this comprehensive review suggests that both EIMD and RBE are age, and sex specific. Delayed onset muscle soreness played a major role in both EIMD and RBE in all the population types. Female participants are less susceptible to EIMD as compared to age-matched male counterparts. Moreover, both EIMD and RBE are more elicited in middle aged and younger adults as compared to children and older adults while the magnitude of RBE turns out to be minimal in trained individuals due to persisting adaptations.
{"title":"Exercise induced muscle damage and repeated bout effect: an update for last 10 years and future perspectives","authors":"A. Rai, P. Bhati, P. Anand","doi":"10.3920/cep220025","DOIUrl":"https://doi.org/10.3920/cep220025","url":null,"abstract":"Exercise-induced muscle damage (EIMD) and repeated bout effect (RBE) are widely researched across various populations. EIMD is the muscle damage occurring after one bout of unaccustomed exercise while RBE is the attenuation of the same muscle damage in subsequent second bout. RBE seems to have significant implications for exercise prescription. Despite existence of vast literature, there is lack of clarity on the effects of EIMD and RBE in a healthy population. The purpose of this study is to review the literature on EIMD and RBE in healthy participants published during the last 10 years. The search of major databases (including Scopus, Google Scholar and PubMed) was conducted using specific keywords ‘Exercise induced muscle damage’, ‘Repeated bout effect’, ‘Healthy participants’ ‘Pre-conditioning’, ‘Eccentric exercise’. Studies published from 2011 onwards which included EIMD and RBE assessment in healthy participants were included in this review. Database searching revealed a total of 38 studies on EIMD and RBE in healthy participants. Three major themes of papers were identified that focused on EIMD and RBE along with (1) age related differences, (2) sex-based differences, and (3) response in athletes. Findings of this comprehensive review suggests that both EIMD and RBE are age, and sex specific. Delayed onset muscle soreness played a major role in both EIMD and RBE in all the population types. Female participants are less susceptible to EIMD as compared to age-matched male counterparts. Moreover, both EIMD and RBE are more elicited in middle aged and younger adults as compared to children and older adults while the magnitude of RBE turns out to be minimal in trained individuals due to persisting adaptations.","PeriodicalId":10709,"journal":{"name":"Comparative Exercise Physiology","volume":"9 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84469898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Surface electromyography (EMG) and mean force can be used to identify motor unit excitation and fatigue. Low-load resistance training with blood flow restriction (LL+BFR) may result in earlier fatigue and maximal muscle fibre recruitment compared to low-load resistance training (LL). The purpose of this investigation was to examine EMG and force responses during LL versus LL+BFR. Thirteen males (mean ± standard deviation = 24±4 years) completed a bout (1×30) of leg extension muscle actions at 30% of their 1 repetition maximum LL and LL+BFR while force, EMG amplitude, and EMG mean power frequency (EMG MPF) were recorded. EMG amplitude increased (74.2%) and EMG MPF decreased (22.6%) similarly during both conditions. There was no significant difference in mean force during the first 3 repetitions between LL+BFR (477.3±132.3 N) and LL (524.3±235.1 N) conditions, but mean force was lower during the last 3 repetitions for LL+BFR (459.7±179.3 N) compared to LL (605.4±276.4 N). The results of the present study indicated that a fatiguing bout of leg extension muscle actions performed LL and LL+BFR elicited similar neuromuscular responses. There was a significant difference in mean force during the last 3 repetitions (LL>LL+BFR) that may have been due to differences in the time spent near peak force.
{"title":"Neuromuscular and mean force changes during a fatiguing bout of exercise with and without blood flow restriction","authors":"C. Proppe, P. Rivera, E. Beltran, E. Hill","doi":"10.3920/cep220023","DOIUrl":"https://doi.org/10.3920/cep220023","url":null,"abstract":"Surface electromyography (EMG) and mean force can be used to identify motor unit excitation and fatigue. Low-load resistance training with blood flow restriction (LL+BFR) may result in earlier fatigue and maximal muscle fibre recruitment compared to low-load resistance training (LL). The purpose of this investigation was to examine EMG and force responses during LL versus LL+BFR. Thirteen males (mean ± standard deviation = 24±4 years) completed a bout (1×30) of leg extension muscle actions at 30% of their 1 repetition maximum LL and LL+BFR while force, EMG amplitude, and EMG mean power frequency (EMG MPF) were recorded. EMG amplitude increased (74.2%) and EMG MPF decreased (22.6%) similarly during both conditions. There was no significant difference in mean force during the first 3 repetitions between LL+BFR (477.3±132.3 N) and LL (524.3±235.1 N) conditions, but mean force was lower during the last 3 repetitions for LL+BFR (459.7±179.3 N) compared to LL (605.4±276.4 N). The results of the present study indicated that a fatiguing bout of leg extension muscle actions performed LL and LL+BFR elicited similar neuromuscular responses. There was a significant difference in mean force during the last 3 repetitions (LL>LL+BFR) that may have been due to differences in the time spent near peak force.","PeriodicalId":10709,"journal":{"name":"Comparative Exercise Physiology","volume":"12 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2022-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79608356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
W. Liu, M. Akbarpour-Beni, S. Movahed, A. Gorzi, E. Cheraghi, H. Amini
The objective of this study was to investigate the effect of eight weeks of propolis and chicory on oxidative stress of uterine tissue in rats consuming testosterone enanthate. Thirty-five female Wistar rats (8 weeks old and weighing 200±12 g) were randomly divided between five groups (n=8) resistance training+ testosterone enanthate (RT+TE), resistance training+ testosterone enanthate+ chicory (RT+TE+CH), resistance training+ testosterone enanthate+ propolis (RT+TE+PR), control (CO), and sham (RT). The protocols were as follows: exercise protocol including climb on a 1-meter ladder with 26 steps five days a week for eight weeks, received a dose of 20 mg/kg of body weight of testosterone weekly for eight weeks, and received a dose of 400 mg/kg proplis and 6 g/kg chicory of body weight all days a week for eight weeks. Superoxide dismutase (SOD), glutathione peroxidase (GPX), and malondialdehyde (MDA) were measured as oxidative stress markers. Testosterone treatment resulted in a significant decrease in the amount of SOD and GPX only in RT+TE group compared to the RT+TE+CH and RT+TE+PR groups (P=0.001). There was no significant difference in mean SOD and GPX levels between RT+TE+CH and RT+TE+PR with CO and RT groups (P>0.05). MDA level was significantly higher in RT+TE group compared to the other groups (P=0.001). This level was also significantly higher in RT+TE+CH group compared to the CO group (P=0.000) and in RT+TE+PR group compared to CO (P=0.000) and RT (P=0.003) groups. Although testosterone enanthate leads to oxidative stress in uterine tissue, propolis and chicory reduced this oxidative stress. It seems that more research can be done on the potential effects of natural antioxidants to neutralise the harmful effects of steroids.
{"title":"Neutralising the testosterone enanthate-induced oxidative stress in rats uterine tissue by propolis and chicory as natural antioxidants","authors":"W. Liu, M. Akbarpour-Beni, S. Movahed, A. Gorzi, E. Cheraghi, H. Amini","doi":"10.3920/cep220010","DOIUrl":"https://doi.org/10.3920/cep220010","url":null,"abstract":"The objective of this study was to investigate the effect of eight weeks of propolis and chicory on oxidative stress of uterine tissue in rats consuming testosterone enanthate. Thirty-five female Wistar rats (8 weeks old and weighing 200±12 g) were randomly divided between five groups (n=8) resistance training+ testosterone enanthate (RT+TE), resistance training+ testosterone enanthate+ chicory (RT+TE+CH), resistance training+ testosterone enanthate+ propolis (RT+TE+PR), control (CO), and sham (RT). The protocols were as follows: exercise protocol including climb on a 1-meter ladder with 26 steps five days a week for eight weeks, received a dose of 20 mg/kg of body weight of testosterone weekly for eight weeks, and received a dose of 400 mg/kg proplis and 6 g/kg chicory of body weight all days a week for eight weeks. Superoxide dismutase (SOD), glutathione peroxidase (GPX), and malondialdehyde (MDA) were measured as oxidative stress markers. Testosterone treatment resulted in a significant decrease in the amount of SOD and GPX only in RT+TE group compared to the RT+TE+CH and RT+TE+PR groups (P=0.001). There was no significant difference in mean SOD and GPX levels between RT+TE+CH and RT+TE+PR with CO and RT groups (P>0.05). MDA level was significantly higher in RT+TE group compared to the other groups (P=0.001). This level was also significantly higher in RT+TE+CH group compared to the CO group (P=0.000) and in RT+TE+PR group compared to CO (P=0.000) and RT (P=0.003) groups. Although testosterone enanthate leads to oxidative stress in uterine tissue, propolis and chicory reduced this oxidative stress. It seems that more research can be done on the potential effects of natural antioxidants to neutralise the harmful effects of steroids.","PeriodicalId":10709,"journal":{"name":"Comparative Exercise Physiology","volume":"09 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2022-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85984129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Migraine is a type of primary headache with a high degree of associated disability that can present with a variety of indications and co-morbidities. The role of physical therapy treatment in migraine management is largely obscure. To investigate the combine effect of aerobic exercises and therapeutic pain neuroscience education on disability, pain pressure threshold, head posture and quality of life (QoL) in patients having migraine. Subjects were screened by using Migraine Disability Assessment (MIDAS) and after screening total sample of 50 subjects were randomly assigned into two groups: Group A (Experimental, n=25) and Group B (Control, n=25). Migraine disability assessment, pressure algometer, craniovertebral angle (CVA) and migraine specific quality of life were examined before and after 6 weeks of the intervention. Group A were given aerobic exercises and therapeutic pain neuroscience education along with conventional treatment for 45 min 3 days/week for 6 weeks, whereas participants in the Group B performed conventional exercises alone for 20 min 3 days/week for 6 weeks. Significant differences were observed in migraine disability score (P=0.003) and pain pressure threshold (P=0.039, P=0.030 and P=0.025) and improvement in forward head posture (P=0.001) between the groups after the intervention period, signifying greater improvement in the group A. QoL also improved in both the groups after intervention. Main findings of the present study suggest that the therapeutic pain neuroscience education and aerobic exercises combined with conventional treatment together maybe helpful to give better quality of life, reduced disability, increased pain pressure threshold and increased CVA to patients with migraine.
{"title":"Effect of aerobic exercises and therapeutic pain neuroscience education on disability, pain, head posture and QOL in migraine patients","authors":"A. Gupta, S Kumar, P. Rishi","doi":"10.3920/cep220029","DOIUrl":"https://doi.org/10.3920/cep220029","url":null,"abstract":"Migraine is a type of primary headache with a high degree of associated disability that can present with a variety of indications and co-morbidities. The role of physical therapy treatment in migraine management is largely obscure. To investigate the combine effect of aerobic exercises and therapeutic pain neuroscience education on disability, pain pressure threshold, head posture and quality of life (QoL) in patients having migraine. Subjects were screened by using Migraine Disability Assessment (MIDAS) and after screening total sample of 50 subjects were randomly assigned into two groups: Group A (Experimental, n=25) and Group B (Control, n=25). Migraine disability assessment, pressure algometer, craniovertebral angle (CVA) and migraine specific quality of life were examined before and after 6 weeks of the intervention. Group A were given aerobic exercises and therapeutic pain neuroscience education along with conventional treatment for 45 min 3 days/week for 6 weeks, whereas participants in the Group B performed conventional exercises alone for 20 min 3 days/week for 6 weeks. Significant differences were observed in migraine disability score (P=0.003) and pain pressure threshold (P=0.039, P=0.030 and P=0.025) and improvement in forward head posture (P=0.001) between the groups after the intervention period, signifying greater improvement in the group A. QoL also improved in both the groups after intervention. Main findings of the present study suggest that the therapeutic pain neuroscience education and aerobic exercises combined with conventional treatment together maybe helpful to give better quality of life, reduced disability, increased pain pressure threshold and increased CVA to patients with migraine.","PeriodicalId":10709,"journal":{"name":"Comparative Exercise Physiology","volume":"46 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2022-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83675524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Previous research has reported significant psychological consequences of injury on rehabilitation success, performance, and wellbeing in athletes, although little is known within horse-based sports. There is a high prevalence of injury reported in point-to-point (P2P) jockeys, but despite this, comparatively little research exists examining the psychological implications resulting from physical trauma within horseracing. The aim of this study was to investigate the psychological responses to personal injury in British amateur P2P jockeys. Five amateur P2P jockeys (two male, three female, x- age 25 years old) were interviewed about their experiences post an injury sustained during racing in the preceding 12 months. Interview questions explored their pre-injury career, the rehabilitation phase, pre-return to racing phase issues and coping strategies used by jockeys. Thematic analysis revealed three higher order themes: emotional responses, coping strategies, and factors affecting recovery. Subjects universally cited negative emotional responses following injury, including grief, a sense of loss, and frustration, and all experienced denial at the onset of injury. Typical coping strategies included strong support networks of family, friends and racing staff, and goal setting. Fear of reinjury was identified by all athletes, particularly on return to the saddle, and the attitudes towards injury management, such as denial, seen in this study may provide opportunities to develop targeted education campaigns for P2P jockeys on injury services. Targeted marketing for P2P jockeys on available injury support is recommended, such as seen for professional jockeys, as well as the creation of career development resources to offer alternative routes for P2P jockeys following injury.
{"title":"The psychological responses of British amateur point-to-point jockeys to personal injury","authors":"Ewan Davies, L. Steel","doi":"10.3920/cep220028","DOIUrl":"https://doi.org/10.3920/cep220028","url":null,"abstract":"Previous research has reported significant psychological consequences of injury on rehabilitation success, performance, and wellbeing in athletes, although little is known within horse-based sports. There is a high prevalence of injury reported in point-to-point (P2P) jockeys, but despite this, comparatively little research exists examining the psychological implications resulting from physical trauma within horseracing. The aim of this study was to investigate the psychological responses to personal injury in British amateur P2P jockeys. Five amateur P2P jockeys (two male, three female, x- age 25 years old) were interviewed about their experiences post an injury sustained during racing in the preceding 12 months. Interview questions explored their pre-injury career, the rehabilitation phase, pre-return to racing phase issues and coping strategies used by jockeys. Thematic analysis revealed three higher order themes: emotional responses, coping strategies, and factors affecting recovery. Subjects universally cited negative emotional responses following injury, including grief, a sense of loss, and frustration, and all experienced denial at the onset of injury. Typical coping strategies included strong support networks of family, friends and racing staff, and goal setting. Fear of reinjury was identified by all athletes, particularly on return to the saddle, and the attitudes towards injury management, such as denial, seen in this study may provide opportunities to develop targeted education campaigns for P2P jockeys on injury services. Targeted marketing for P2P jockeys on available injury support is recommended, such as seen for professional jockeys, as well as the creation of career development resources to offer alternative routes for P2P jockeys following injury.","PeriodicalId":10709,"journal":{"name":"Comparative Exercise Physiology","volume":"210 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2022-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77588978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prolonged multiday exercise in dogs is often associated with a caloric deficit that can lead to changes in body composition but may also result in an increase in lean body mass due to a conditioning effect. To test the hypothesis that multiday exercise decreases fat mass but increases lean body mass, body composition was measured using deuterium oxide dilution in a team of racing Alaskan sled dogs competing in a multiday race. Twelve dogs completed 961 km in 6 days, resulting in a 3% decrease in body mass (P=0.003) and 16% decrease in body fat (P=0.005), and an increase in total body water as a fraction of body mass (P=0.01). Within the study population, there was considerable dog-to-dog variation, with 2 dogs gaining fat mass and 2 dogs losing over 40% of their pre-race fat mass during the measurement period. These results confirm that dogs participating in multiday exercise events are at risk for loss of body fat reserve, likely due to a net calorie deficit. However, individual dog responses to an exercise challenge can be highly variable, emphasizing the need for careful assessment of individual dogs.
{"title":"Effect of multiday endurance exercise on total body water and calculated body composition in racing sled dogs","authors":"M. Davis","doi":"10.3920/cep220035","DOIUrl":"https://doi.org/10.3920/cep220035","url":null,"abstract":"Prolonged multiday exercise in dogs is often associated with a caloric deficit that can lead to changes in body composition but may also result in an increase in lean body mass due to a conditioning effect. To test the hypothesis that multiday exercise decreases fat mass but increases lean body mass, body composition was measured using deuterium oxide dilution in a team of racing Alaskan sled dogs competing in a multiday race. Twelve dogs completed 961 km in 6 days, resulting in a 3% decrease in body mass (P=0.003) and 16% decrease in body fat (P=0.005), and an increase in total body water as a fraction of body mass (P=0.01). Within the study population, there was considerable dog-to-dog variation, with 2 dogs gaining fat mass and 2 dogs losing over 40% of their pre-race fat mass during the measurement period. These results confirm that dogs participating in multiday exercise events are at risk for loss of body fat reserve, likely due to a net calorie deficit. However, individual dog responses to an exercise challenge can be highly variable, emphasizing the need for careful assessment of individual dogs.","PeriodicalId":10709,"journal":{"name":"Comparative Exercise Physiology","volume":"48 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2022-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88002675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Andraini, J. Mardatillah, N. T. Kartinah, N. Paramita, Dewi Irawati Soeria Santoso, S. Yolanda, B.C. Puspasari, H. Rusli
Diabetes mellitus (DM) is a metabolic disorder associated with declining of memory function. Glucagon like peptide-1 (GLP-1) has a role on memory function; binding of GLP-1 and GLP-1 receptor (GLP-1R) can enhance synaptic plasticity. Physical exercise has effect in increasing GLP-1 levels mediated by interleukin (IL)-6 in plasma. However, the effect of physical exercise on GLP-1 and GLP-1R in hippocampus is still unclear. Therefore, we investigated the effect of continuous and interval training on memory function through GLP-1/GLP-1R and its relation to hippocampal IL-6 of DM rats. This was an experimental study using 8-week-old Wistar rats, divided into four groups: normal control (Con); DM control (ConDM); DM with continuous training (DM-CT); and DM with interval training (DM-IT). DM-CT and DM-IT rats were trained six times a week for six weeks. All rats performed the forced alteration Y-maze test to verify spatial memory function. We analysed GLP-1 and IL-6 level by ELISA and GLP-1R by RT-PCR. We found decreased spatial memory function in DM rats accompanied by decreased hippocampal GLP-1 and GLP-1R. Physical exercise promote memory function in DM rats associated with restoration of hippocampal GLP-1 or GLP-1R level. The GLP-1 level is associated with hippocampal IL-6 level. Continuous training slightly increases GLP-1 level while interval training can maintain expression of hippocampal GLP-1R in DM rats. Our findings suggest that physical exercise may promote memory function by slightly increase the level of hippocampal GLP-1 and maintaining expression hippocampal GLP-1R.
{"title":"Physical exercise promotes memory function in diabetes mellitus rats: a look at glucagon like peptide-1 and glucagon like peptide-1 receptor","authors":"T. Andraini, J. Mardatillah, N. T. Kartinah, N. Paramita, Dewi Irawati Soeria Santoso, S. Yolanda, B.C. Puspasari, H. Rusli","doi":"10.3920/cep220020","DOIUrl":"https://doi.org/10.3920/cep220020","url":null,"abstract":"Diabetes mellitus (DM) is a metabolic disorder associated with declining of memory function. Glucagon like peptide-1 (GLP-1) has a role on memory function; binding of GLP-1 and GLP-1 receptor (GLP-1R) can enhance synaptic plasticity. Physical exercise has effect in increasing GLP-1 levels mediated by interleukin (IL)-6 in plasma. However, the effect of physical exercise on GLP-1 and GLP-1R in hippocampus is still unclear. Therefore, we investigated the effect of continuous and interval training on memory function through GLP-1/GLP-1R and its relation to hippocampal IL-6 of DM rats. This was an experimental study using 8-week-old Wistar rats, divided into four groups: normal control (Con); DM control (ConDM); DM with continuous training (DM-CT); and DM with interval training (DM-IT). DM-CT and DM-IT rats were trained six times a week for six weeks. All rats performed the forced alteration Y-maze test to verify spatial memory function. We analysed GLP-1 and IL-6 level by ELISA and GLP-1R by RT-PCR. We found decreased spatial memory function in DM rats accompanied by decreased hippocampal GLP-1 and GLP-1R. Physical exercise promote memory function in DM rats associated with restoration of hippocampal GLP-1 or GLP-1R level. The GLP-1 level is associated with hippocampal IL-6 level. Continuous training slightly increases GLP-1 level while interval training can maintain expression of hippocampal GLP-1R in DM rats. Our findings suggest that physical exercise may promote memory function by slightly increase the level of hippocampal GLP-1 and maintaining expression hippocampal GLP-1R.","PeriodicalId":10709,"journal":{"name":"Comparative Exercise Physiology","volume":"15 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2022-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72721651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Wright, E. Hernlund, C. Fjordbakk, B. Ytrehus, E. Law, M. Uhlhorn, M. Rhodin
Patellar ligament desmopathy in horses is regarded as an uncommon condition with unclear aetiology. Of the three patellar ligaments in the horse, the intermediate is the one most often diagnosed with desmopathy in horses presenting with chronic lameness. This structure corresponds to the patellar tendon in humans. As diagnostic imaging modalities continuously improve, changes in echogenicity of the patellar ligaments are identified ultrasonographically with increasing frequency. However, disruption of the normal fibre pattern may be present also in patellar ligaments in horses that show no signs of lameness. Similarly, there is a poor correlation between pain and diagnostic imaging findings in human patellar tendinopathy. Consequently, there appears to be a knowledge gap pertaining to normal ultrasonographic variation and diagnostic criteria for disease of the patellar ligaments in horses. Furthermore, local anaesthetic techniques to verify the diagnosis are poorly described, and due to the low number of treated cases, no specific treatment modality can be recommended on a scientific basis. The aim of this paper is to review the current knowledge regarding the pathogenesis, diagnosis and management of patellar ligament desmopathy in horses, compare this condition with patellar tendinopathy in humans, and identify areas for further research to increase the diagnostic accuracy in horses. We conclude that there is a profound need for better descriptions of ultrasonographic variation and pathological changes of the equine patellar ligaments. Identification of areas of maximal ligament strain and descriptions of early histopathological changes could render more information on the possible aetiology, preventive measurements and treatment options of desmopathy. Description of regional innervation could aid in development of methods for diagnostic anaesthesia to verify pain originating from the ligaments.
{"title":"Patellar ligament desmopathy in the horse – a review and comparison to human patellar tendinopathy (‘Jumper’s knee’)","authors":"L. Wright, E. Hernlund, C. Fjordbakk, B. Ytrehus, E. Law, M. Uhlhorn, M. Rhodin","doi":"10.3920/cep220011","DOIUrl":"https://doi.org/10.3920/cep220011","url":null,"abstract":"Patellar ligament desmopathy in horses is regarded as an uncommon condition with unclear aetiology. Of the three patellar ligaments in the horse, the intermediate is the one most often diagnosed with desmopathy in horses presenting with chronic lameness. This structure corresponds to the patellar tendon in humans. As diagnostic imaging modalities continuously improve, changes in echogenicity of the patellar ligaments are identified ultrasonographically with increasing frequency. However, disruption of the normal fibre pattern may be present also in patellar ligaments in horses that show no signs of lameness. Similarly, there is a poor correlation between pain and diagnostic imaging findings in human patellar tendinopathy. Consequently, there appears to be a knowledge gap pertaining to normal ultrasonographic variation and diagnostic criteria for disease of the patellar ligaments in horses. Furthermore, local anaesthetic techniques to verify the diagnosis are poorly described, and due to the low number of treated cases, no specific treatment modality can be recommended on a scientific basis. The aim of this paper is to review the current knowledge regarding the pathogenesis, diagnosis and management of patellar ligament desmopathy in horses, compare this condition with patellar tendinopathy in humans, and identify areas for further research to increase the diagnostic accuracy in horses. We conclude that there is a profound need for better descriptions of ultrasonographic variation and pathological changes of the equine patellar ligaments. Identification of areas of maximal ligament strain and descriptions of early histopathological changes could render more information on the possible aetiology, preventive measurements and treatment options of desmopathy. Description of regional innervation could aid in development of methods for diagnostic anaesthesia to verify pain originating from the ligaments.","PeriodicalId":10709,"journal":{"name":"Comparative Exercise Physiology","volume":"34 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2022-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81315207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Well-developed musculature is important for performance yet difficult to quantify. Recently, we validated infrared 3-dimensional (3-D) photonic scanning as an accurate measure of body volume and proxy for regional muscle mass in horses. Our current objective was to determine the impact of body position on measures of lumbar (LV) and hindquarter (HQV) volume. Anatomic markers were placed on 8 horses, positioned at: (1) four hooves square, (2) neck turned ~25°, (3) head raised mean 17 cm, (4) one hind hoof (HH) forward 14±5 cm, (5) a front and contralateral HH ~15 cm all offset, (6) one HH resting. A handheld Occipital Structure Sensor photonic scanner, iPad, Skanect and Materialise 3-Matic programs captured LV and HQV. Measured LV and HQV for whole, same and opposite-side with altered head positions and whole LV and HQV with altered HH positions were compared to volume standing square using repeated measures ANOVA. The volumes of the opposite-side or same-side with altered HH positions were compared to the corresponding side when square using a paired t test with multiple test correction (P<0.017). Head elevated negatively impacted measured left LV (-10% difference, P=0.1) compared to square, however, differences were not significant. Head turned did not impact measured LV. Resting HH significantly increased measured whole (18%, P=0.04) and same-side LV (49%, P=0.001) versus square but not the opposite-side LV. One HH forward (whole 16%, P=0.02; same-side 19%, P=0.01) or all offset (whole 14%, P=0.002; same-side 27%, P=0.0001) significantly increased measured whole or same-side LV versus square. Measured HQV was not impacted by head elevated or limb position but was 2% higher on the opposite-side of the turned head (P=0.01). We conclude that alterations in body position have minimal impact on measured HQV, whereas accurate assessment of LV requires horses stand squarely.
{"title":"The impact of body position on measurement of equine lumbar and hindquarter volume using 3-dimensional scans","authors":"A. Borer-Matsui, C. Donnelly, S. Valberg","doi":"10.3920/cep220021","DOIUrl":"https://doi.org/10.3920/cep220021","url":null,"abstract":"Well-developed musculature is important for performance yet difficult to quantify. Recently, we validated infrared 3-dimensional (3-D) photonic scanning as an accurate measure of body volume and proxy for regional muscle mass in horses. Our current objective was to determine the impact of body position on measures of lumbar (LV) and hindquarter (HQV) volume. Anatomic markers were placed on 8 horses, positioned at: (1) four hooves square, (2) neck turned ~25°, (3) head raised mean 17 cm, (4) one hind hoof (HH) forward 14±5 cm, (5) a front and contralateral HH ~15 cm all offset, (6) one HH resting. A handheld Occipital Structure Sensor photonic scanner, iPad, Skanect and Materialise 3-Matic programs captured LV and HQV. Measured LV and HQV for whole, same and opposite-side with altered head positions and whole LV and HQV with altered HH positions were compared to volume standing square using repeated measures ANOVA. The volumes of the opposite-side or same-side with altered HH positions were compared to the corresponding side when square using a paired t test with multiple test correction (P<0.017). Head elevated negatively impacted measured left LV (-10% difference, P=0.1) compared to square, however, differences were not significant. Head turned did not impact measured LV. Resting HH significantly increased measured whole (18%, P=0.04) and same-side LV (49%, P=0.001) versus square but not the opposite-side LV. One HH forward (whole 16%, P=0.02; same-side 19%, P=0.01) or all offset (whole 14%, P=0.002; same-side 27%, P=0.0001) significantly increased measured whole or same-side LV versus square. Measured HQV was not impacted by head elevated or limb position but was 2% higher on the opposite-side of the turned head (P=0.01). We conclude that alterations in body position have minimal impact on measured HQV, whereas accurate assessment of LV requires horses stand squarely.","PeriodicalId":10709,"journal":{"name":"Comparative Exercise Physiology","volume":"84 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2022-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74187117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：