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Cinacalcet HCl Loaded PLGA Nanoparticles Using the Porous Carrier 利用多孔载体负载氯化钠的PLGA纳米颗粒
Q3 Materials Science Pub Date : 2022-04-18 DOI: 10.2174/2405461507666220418113115
Dipthi Shree, C. Patra, D. Ghose, G. Jena, B. Sahoo, K. C. Panigrahi, J. Sruti
Cinacalcet HCl, a calcimimetic, BCS class IV drug with low oral bioavailability. Polymeric nanoparticles are widely used as biomaterials owing to their biocompatibility, biodegradability, varied structures, low toxicity, simple and easy formulation process.To enhance the oral bioavailability of poorly water soluble drug i.e., Cinacalcet HCl by using a suitable particulate nanocarrier system i.e., Polymeric Nanoparticles.A Biodegradable Cinacalcet HCl (CH) loaded Poly (Lactic-co-glycolic acid) (PLGA) nanoparticles were prepared by nano precipitation method using Poloxamer-188 as stabilizer. The experimental parameters like polymer concentration, stabilizer concentration, temperature and RPM speed were optimized. An optimized Polymeric nanoparticles (PNP F8) was solidified by adsorption to porous carrier sylysia 350.PNP F8 exhibited particle size 155 nm with low PDI (0.231) and high zeta potential (-21.3 mV). In vitro diffusion study revealed sustain release of CH for 24 h for both PNP (F8) and solidified PNP (F8). Pharmacokinetics after oral administration of PNP (F8) and solidified PNP (F8) exhibited 5 fold increases in bioavailability. Thus, both PNP (F8) and solidified PNP (F8) showed significant improvement in oral bioavailability.Adsorption to polymeric nanoparticles to porous carriers like sylysia 350 can be considered as a promising approach for its long term stability.
盐酸Cinacalcet,一种含钙的BCS IV类药物,口服生物利用度低。聚合物纳米粒子具有生物相容性、生物降解性、结构多样、低毒性强、配制工艺简单易行等优点,被广泛用作生物材料。为了提高难溶性药物Cinacalcet HCl的口服生物利用度,使用合适的颗粒纳米载体系统,即聚合物纳米颗粒。以泊洛沙姆-188为稳定剂,通过纳米沉淀法制备了可生物降解的Cinacalcet-HCl(CH)负载的聚乳酸(PLGA)纳米颗粒。对聚合物浓度、稳定剂浓度、温度和转速等实验参数进行了优化。优化的聚合物纳米颗粒(PNP F8)通过吸附到多孔载体sylysia 350上而固化。PNP F8表现出具有低PDI(0.231)和高ζ电位(-21.3mV)的155nm的颗粒尺寸。体外扩散研究显示,对于PNP(F8)和固化的PNP(F8-),CH持续释放24小时。口服PNP(F8)和固化PNP(F8-)后的药代动力学显示生物利用度增加了5倍。因此,PNP(F8)和固化PNP(F8-)都显示出口服生物利用度的显著提高。将聚合物纳米颗粒吸附到像sylysia 350这样的多孔载体上可以被认为是一种有前途的方法,因为它具有长期稳定性。
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引用次数: 0
Study of multilayered Cobalt Silicide Nanostructured Thin films prepared by Ion Beam Sputtering 离子束溅射制备多层硅化钴纳米薄膜的研究
Q3 Materials Science Pub Date : 2022-04-17 DOI: 10.2174/2405461507666220417003137
Karamjit Kaur, Anil Kumar
This work focuses on the different existing techniques for synthesis of nanomaterials, the selec-tion of potential process for preparation of Co/Si and Co/Si/Co such that material with optimum charac-teristics may be obtainedThe process of synthesis plays a crucial role in physical properties and associated phenom-ena acquired by them and hence is a deciding factor in various potential applications of the materials.To study the properties of multi-layered Cobalt Silicide Nanostructured Thin films prepared by Ion Beam Sputtering.The cobalt silicide is selected for synthesis using IBS technique owing to vast scope of its application in manufacturing microelectronic devices.The formation of nanostructured layers is confirmed through XRD and XRR patterns.The role of substrate thickness, interface quality and crystalline structure is very important in deciding properties of multilayers nano-structured thin films.
这项工作的重点是合成纳米材料的不同现有技术,选择制备Co/Si和Co/Si/Co的潜在工艺,以获得具有最佳特性的材料。合成工艺对它们获得的物理性能和相关现象起着至关重要的作用,因此是材料各种潜在应用的决定因素。研究离子束溅射制备的多层硅化钴纳米结构薄膜的性能。由于硅化钴在微电子器件制造中的广泛应用,选择采用IBS技术合成硅化钴。通过XRD和XRR图谱证实了纳米结构层的形成。衬底厚度、界面质量和晶体结构在决定多层纳米结构薄膜性能方面起着非常重要的作用。
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引用次数: 0
A review of nanoparticles characterization techniques 纳米颗粒表征技术综述
Q3 Materials Science Pub Date : 2022-04-05 DOI: 10.2174/2405461507666220405113715
P. Wadhwa, Sushant Sharma, S. Sahu, A. Sharma, D. Kumar
Nanoparticles (NPs) are small materials of sizes 1 to 100 nm and can be divided into different categories according to their properties, shapes, or sizes. They can be classified as metal nanoparticles, carbon-based nanoparticles, semiconductor nanoparticles, ceramics nanoparticles, polymeric nanoparticles, and lipid-based nanoparticles. The basic characteristics used while characterizing the nanoparticles are morphology, size, surface charge, and optical properties. SEM, environmental SEM (ESEM), tip-enhanced Raman spectroscopy (TERS), scanning tunneling microscopy (STM), and TEM are used to study the topography and morphology of nanoparticles. Spectral analysis is employed to check optical properties, while, X-ray crystallography (XRD), energy-dispersive X-ray (EDX) spectroscopy, Fourier transform infrared spectroscopy (FTIR), and fluorescence correlation spectroscopy (FCS) are used for learning the fundamental properties of nanoparticles (NPs). This review will focus on the utilization of these techniques in the characterization of nanoparticles.
纳米颗粒(NP)是尺寸为1至100nm的小材料,根据其性质、形状或尺寸可分为不同类别。它们可以分为金属纳米颗粒、碳基纳米颗粒、半导体纳米颗粒、陶瓷纳米颗粒、聚合物纳米颗粒和脂质基纳米颗粒。表征纳米颗粒时使用的基本特征是形态、尺寸、表面电荷和光学性质。使用SEM、环境SEM(ESEM)、尖端增强拉曼光谱(TERS)、扫描隧道显微镜(STM)和TEM来研究纳米颗粒的形貌和形态。光谱分析用于检查光学性质,而X射线晶体学(XRD)、能量色散X射线(EDX)光谱、傅立叶变换红外光谱(FTIR)和荧光相关光谱(FCS)用于学习纳米颗粒(NP)的基本性质。这篇综述将集中于这些技术在纳米颗粒表征中的应用。
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引用次数: 2
Optimization of Nano Science Parameters for Extracting Phenolic Compounds from Ficus religiosa by Three-Phase Partitioning (TPP) Method 三相分割法提取榕中酚类化合物的纳米科学参数优化
Q3 Materials Science Pub Date : 2022-03-21 DOI: 10.2174/1573401318666220321140651
N. Rane, S. Shewale
The phenolic compounds are generally found in different parts of the plants such as leaves, barks, seeds, fruits, and so on. These compounds show numerous nanoscience-based bioactive properties including antioxidant characteristics. The phenolic compounds obtained from beneficial herbs and dietary plants include total phenolic compounds, flavonoids, and tannins. In recent times, nanoscience has proved to be extensively reliable in extracting bioactive components. Additionally, nanomaterials have made a considerable contribution in the development of methodical techniques to retain superiority in processing foods and medicines.Of late, extracting nano-bioactive composites from natural resources have gained high interest as these composites are used in manufacturing a wide range of products such as foods, paints, and pharmaceuticals. Therefore, there is a requirement to separate natural products and identify new nano-bioactive compounds that have the potential to improve the importance of logical and developed techniques.This research is focused on optimizing the experimental parameters to extract the phenolic compounds from Ficus religiosa (banyan leaves) by the Three-Phase Partitioning (TPP) method. TPP is an advanced method that has been used for the extraction, concentration, and purification of various nano-based bioactive compounds and enzymes.During the investigation, various experimental parameters have been studied to obtain the maximum concentration of phenolic compounds from the dried powder of the Ficus religiosa leaves. The optimised results were found as ammonium sulphate by 30%, solute to the solvent ratio in 1:20 (v/v), and slurry to t-butanol ratio in 1:1 proportions.
酚类化合物通常存在于植物的不同部位,如叶子、树皮、种子、果实等。这些化合物表现出许多基于纳米科学的生物活性,包括抗氧化特性。从有益草药和膳食植物中获得的酚类化合物包括总酚类化合物、黄酮类化合物和单宁。近年来,纳米科学已被证明在提取生物活性成分方面具有广泛的可靠性。此外,纳米材料在发展系统技术以保持食品和药品加工优势方面做出了相当大的贡献。最近,从自然资源中提取纳米生物活性复合材料引起了人们的高度兴趣,因为这些复合材料用于制造食品、涂料和药品等广泛的产品。因此,需要分离天然产物并鉴定新的纳米生物活性化合物,这些化合物有可能提高逻辑和开发技术的重要性。本研究采用三相分配法(TPP)对榕树叶中酚类化合物的提取工艺参数进行了优化。TPP是一种先进的方法,已被用于提取、浓缩和纯化各种纳米生物活性化合物和酶。在研究过程中,研究了各种实验参数,以获得宗教榕叶干粉中酚类化合物的最大浓度。优化的结果发现,硫酸铵为30%,溶质与溶剂的比例为1:20(v/v),浆液与叔丁醇的比例为1:1。
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引用次数: 0
NANOSILVER-REINFORCED AgSn ALLOYS FOR DENTAL APPLICATIONS: MECHANICAL BEHAVIOR AND HARDNESS 牙科用纳米增强AgSn合金的力学行为和硬度
Q3 Materials Science Pub Date : 2022-03-09 DOI: 10.2174/2405461507666220309114149
L. Ortega-Arroyo, Eduardo San-Martín-Martínez, Federico H. Barceló, Jorge H. Vargas-Aparicio, Fabio A. Vengoechea-Gómez, V. Castaño
AgSn alloys of different compositions were prepared by direct mixing with silver nanoparticles, synthesized, in turn, by an environmentally-friendly method.The procedure was carried out by following the standard technique for preparing dental materials and devices. A detailed mechanical characterization, including the maximum elongation at break, the ultimate tensile strength and the hardness of the resulting nanocomposites, was obtained and numerically fitted by statistically-significant equationsThe results show improved mechanical performance, as compared to standard materials used in dentistry, in particular amalgams.The procedure described allows to produce low cost materials with tailored mechanical properties.
通过与银纳米颗粒直接混合制备不同成分的AgSn合金,然后通过环保方法合成。该程序是按照制备牙科材料和装置的标准技术进行的。获得了详细的机械特性,包括所得纳米复合材料的最大断裂伸长率、极限拉伸强度和硬度,并通过具有统计学意义的方程进行了数值拟合。结果表明,与牙科中使用的标准材料,特别是汞合金相比,机械性能有所改善。所描述的程序允许生产具有定制机械性能的低成本材料。
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引用次数: 0
A Review on Properties, Synthesis, Surface Functionalization and Application of Nanodiamonds for Antimicrobial Activity 纳米金刚石抗菌性能、合成、表面功能化及应用研究进展
Q3 Materials Science Pub Date : 2022-03-08 DOI: 10.2174/2405461507666220308143436
V. Tyagi, A. Chandra, Neelam Dhankhar, Bhavna Tyagi
Diamond is a metastable carbon allotrope. Nanodiamond is a monocrystalline diamonds having a particle sizes of smaller than 100 nm are known as microdiamonds that has been extensively explored over the last few decades. Nanodiamonds are particularly appealing in order to provide variety of possible applications due to their superior mechanical and optical qualities, wide surface area, ease of bioconjugation, and high biocompatibility. In recent years, NDs have gotten a lot of attention in nanomedicine, and some significant progress has been made. The methods for creating various kinds of nanodiamonds are generalized, including detonation, CVD, hydrothermal and High-Pressure, High-Temperature Microdiamond Milling procedures. The characteristics, properties, synthesis, structure and surface functionalization and applications of nanodiamonds for antimicrobial activity are discussed in this review paper.
金刚石是一种亚稳碳同素异形体。纳米金刚石是一种粒径小于100纳米的单晶金刚石,被称为微金刚石,在过去的几十年里得到了广泛的探索。纳米金刚石由于其优越的机械和光学品质、广泛的表面积、易于生物偶联和高生物相容性,在提供各种可能的应用方面尤其具有吸引力。近年来,纳米nd在纳米医学领域受到了广泛的关注,并取得了一些重大进展。概括了各种制备纳米金刚石的方法,包括爆轰法、气相沉积法、水热法和高压、高温微金刚石铣削法。本文综述了纳米金刚石的特点、性质、合成、结构、表面功能化及其在抗菌方面的应用。
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引用次数: 0
A Review on Unknown Repercussions Associated with Metallic Nanoparticles and their Rectification Techniques 金属纳米粒子的未知反应及其矫正技术综述
Q3 Materials Science Pub Date : 2022-03-04 DOI: 10.2174/2405461507666220304204152
Saman Aqeel, Aparna Gupta, L. Singh
The wide use of metallic nanoparticles (MNPs) has toxic effects on the human body affecting vital organs such as brain, liver and kidney. Therefore it is necessary to develop approaches to eradicate such health issues without compromising plus the potential benefits of the respective metallic nanoparticles including silver, gold, zinc, copper, etc.This study aimed to assess methods which can mutually reduce the nanotoxicity while retaining the therapeutic benefits of metal-based nanocarriers.The implementation of certain methods, such as the addition of chelating agents, providing protective coatings and surface modification during the synthesis of metallic nanoparticles can subsequently minimize metallic toxicity.Through extensive and exhaustive literature survey it was proved that the above strategies are effective in reducing nanotoxic effects which can be further assessed by toxicity assessment tools as biochemistry, histopathology, etc.Metallic nanoparticles have emerged as a beneficial tool for treating various diseases such as cancer, hepatitis, etc. Scientists are also preserving their efficacy by escorting novel techniques for limiting its toxicity, in the world of nanotechnology.
金属纳米颗粒(MNPs)的广泛使用对人体有毒性影响,影响大脑、肝脏和肾脏等重要器官。因此,有必要开发在不损害银、金、锌、铜等相应金属纳米颗粒的潜在益处的情况下根除此类健康问题的方法。本研究旨在评估在保留金属基纳米载体的治疗益处的同时,可以相互降低纳米毒性的方法。在金属纳米颗粒的合成过程中,实施某些方法,如添加螯合剂、提供保护涂层和表面改性,可以随后将金属毒性降至最低。通过广泛而详尽的文献调查,证明上述策略在减少纳米毒性方面是有效的,可以通过生物化学、组织病理学等毒性评估工具进行进一步评估。金属纳米颗粒已成为治疗癌症、肝炎等各种疾病的有益工具。在纳米技术的世界里,科学家们也在为限制其毒性的新技术保驾护航,以保持其功效。
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引用次数: 1
Nanotechnology Applications in Biomedical Systems 纳米技术在生物医学系统中的应用
Q3 Materials Science Pub Date : 2022-03-01 DOI: 10.2174/2405461507666220301121135
I. Buniyamin, R. Akhir, N. Asli, Z. Khusaimi, M. F. Malek, M. Mahmood
Today’s nanotechnology progress in biomedical and biotechnology is to design novel materials with exclusive properties of nanoscale structures. The application of nano-structured materials into biomedical systems has received much attention due to its remarkable resolution in assisting diagnoses and treating medical difficulties. The variety of nanostructured materials produced could be easily controlled and manipulated. Moreover, they could be designed to provide a new property in a predictable manner, whereby the modified biological characteristic and functionalities are compatible with biomedical systems for various applications and purposes. All-inclusive, nanotechnology has an enormous impact on health care and undeniably shaping the future pathway. This paper reviews research methods in nanotechnology developments, which convey benefits to the biomedical application on nano-network and communication, biosensor, nanoprobe, drug delivery system and nano implants.
当今生物医学和生物技术领域的纳米技术进展是设计具有纳米结构特性的新型材料。纳米结构材料在生物医学系统中的应用因其在辅助诊断和治疗医疗困难方面的显着解决方案而受到广泛关注。生产的各种纳米结构材料可以很容易地控制和操纵。此外,它们可以被设计成以可预测的方式提供新的特性,从而修改的生物特性和功能与各种应用和目的的生物医学系统兼容。纳米技术包罗万象,对医疗保健产生了巨大影响,不可否认,它塑造了未来的道路。综述了纳米技术在生物医学领域的研究进展,包括纳米网络与通信、生物传感器、纳米探针、给药系统和纳米植入物等。
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引用次数: 5
Green synthesis of copper oxide nanoparticle using Eichhornia crassipes leaf extract, its Antibacterial and Photocatalytic Activities 绿色氧化铜纳米颗粒的合成及其抑菌和光催化活性研究
Q3 Materials Science Pub Date : 2022-03-01 DOI: 10.2174/2405461507666220301122316
Tamene S. Saligedo, Gutta G. Muleta, T. Tsega, Kirubel Teshome Tadele
Green approach is among the most preferable methods for metal-based nanoparticles synthesis due to its simplicity, cost effectiveness, eco-friendly reagents and broad spectrum of biological activities. The aim of this study is to synthesize copper oxide nanoparticles using Eichhornia Crassipes (Water hyacinth) leaf extract in an eco-friendly manner.Copper oxide nanoparticles were synthesized using Eichhornia Crassipes (Water hyacinth) leaf extract. The effect of different parameters such as concentration of the plant extract, time, light and pH on the formation of the nanoparticles was investigated. The synthesized nanoparticles were characterized by UV-Vis, FTIR, TEM and P-XRD spectroscopic techniques. The antibacterial and photocatalytic activities of the synthesized copper oxide nanoparticles were determined.Powder X Ray diffraction analysis (PXRD) showed that the copper oxide nanoparticles have a size of 9.1 nm. Transmission electron microscopy (TEM) images displayed that the Nps were spherical, polydispersed and well crystallized. The nanoparticles displayed good antibacterial activity against Escherichia coli, Staphylococcus, Bacillus stabtilus and Salmonella typhi with the highest activity against Salmonella typhi.Copper oxide nanoparticles were effectively synthesized and secondary metabolites such as flavonoids, alkaloids, tannins, phenols acted as both capping and stabilizing agents. The good antibacterial and photocatalytic activities of the synthesized nanoparticles indicated their potential for applications in pharmacology and environmental protections respectively. However, the product needs further investigation to enhance its antibacterial potential for efficient pharmacological application.
绿色方法由于其简单、成本效益、环保试剂和广泛的生物活性,是合成金属基纳米颗粒的最优选方法之一。本研究的目的是以环保的方式使用凤眼莲叶提取物合成氧化铜纳米颗粒。利用水葫芦叶提取物合成了氧化铜纳米粒子。研究了植物提取物浓度、时间、光照和pH等不同参数对纳米颗粒形成的影响。用紫外-可见光谱、红外光谱、透射电镜和X-射线衍射对合成的纳米颗粒进行了表征。测定了合成的氧化铜纳米粒子的抗菌和光催化活性。粉末X射线衍射分析(PXRD)显示氧化铜纳米颗粒具有9.1nm的尺寸。透射电子显微镜(TEM)图像显示Nps是球形的、多分散的并且结晶良好。纳米颗粒对大肠杆菌、葡萄球菌、稳定芽孢杆菌和伤寒沙门氏菌具有良好的抗菌活性,对伤寒沙门氏杆菌的抗菌活性最高。有效地合成了氧化铜纳米颗粒,次生代谢产物如黄酮类、生物碱、单宁、酚类既可作为封端剂又可作为稳定剂。合成的纳米颗粒具有良好的抗菌活性和光催化活性,分别表明其在药理学和环境保护方面的应用潜力。然而,该产品需要进一步研究,以增强其有效药理应用的抗菌潜力。
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引用次数: 3
Effect of conditions of the pulsed plasma-chemical synthesis on physicochemical properties of the CuxOy/TiO2 nanocomposite 脉冲等离子体化学合成条件对CuxOy/TiO2纳米复合材料物理化学性能的影响
Q3 Materials Science Pub Date : 2022-02-21 DOI: 10.2174/2405461507666220221095932
R. Sazonov, G. Kholodnaya, D. Ponomarev, O. Lapteva
This work presents the results of study on the effect of multi-pulse electron beam and additional heating of the reaction mixture on the structural and morphological characteristics of the CuxOy/TiO2 nanocomposite prepared by the pulsed plasma-chemical method.The CuxOy/TiO2 nanocomposites were characterized by transmission electron microscopy (TEM), energy dispersive X-ray analysis (EDX), and X-ray diffraction (XRD).It was found that an increase in the impact of a pulsed electron beam on the synthesized composite affected the degree of its agglomeration and the geometric mean particle diameter. Additional heating of the reaction mixture increased the geometric diameter of the synthesized particles (up to 200 nm).The phase composition of the CuxOy/TiO2 nanocomposite changed depending on the synthesis conditions.
本工作介绍了多脉冲电子束和反应混合物的额外加热对通过脉冲等离子体化学方法制备的CuxOy/TiO2纳米复合材料的结构和形态特征的影响的研究结果。通过透射电子显微镜(TEM)、能量色散X射线分析(EDX)和X射线衍射(XRD)对CuxOy/TiO2纳米复合材料进行了表征。发现脉冲电子束对合成的复合材料的冲击增加会影响其团聚程度和几何平均粒径。反应混合物的额外加热增加了合成颗粒的几何直径(高达200nm)。CuxOy/TiO2纳米复合材料的相组成根据合成条件而变化。
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引用次数: 0
期刊
Current Nanomaterials
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