The part of the nanomaterials or secondary compounds in the Bajakah Tampala plant has an important influence on humans. Significantly, in its use as a solution to problems that often occur in health. Biofilm growth on catheters is associated with urinary tract nosocomial infections and causes an increase in mortality every year worldwide. Urinary catheters are a significant factor in CAUTI, with 70 to 80% of infections currently attributable to biofilms. Bajakah Tampala is a native plant of Kalimantan, which has antibacterial activity, but no one has reported its antibiofilm activity. The effectiveness of the Bajakah Tampala antibiofilm against polymicrobial biofilms was analyzed by calculating the minimum biofilm inhibitor concentration (MBIC50) and the minimum biofilm eradication concentration (MBEC50). Flavonoid, alkaloids, and terpenoids compounds are nanomaterials that play an essential role in Bajakah Tampala, where the ethanol extract of Bajakah Tampala has antibacterial and antifungal activity. The ethanol extract of Bajakah Tampala also had antibiofilm activity against mono-species S. aureus, E. coli, and C. albicans in the middle phase (24 hours). It exerted activity against polymicrobial biofilms on the catheter in the middle (24 hours) and maturation phases (48 hours). The results also provide evidence that Bajakah Tampala ethanol extract can eradicate polymicrobial biofilms on catheters. Therefore, Bajakah Tampala can be developed as a candidate for a new antibiofilm agent against polymicrobial biofilms with a nanoparticle approach.
{"title":"Antibiofilm Activity of Polymicrobial Catheters From Bajakah Tampala Plant (Spatholobus littoralis Hassk) Against Staphylococcus aureus, Escherichia coli and Candida albicans","authors":"H. Hamzah, Lysa Oktaviani Saleh, Risca Ainun Jariah, Islamitri Luthfiyah, Qur’anni Akhwatun Husna, Novini, Wirnawati, Khalish Arsy Al Khairy Siregar, Fitriani","doi":"10.2174/2405461507666220627141500","DOIUrl":"https://doi.org/10.2174/2405461507666220627141500","url":null,"abstract":"\u0000\u0000The part of the nanomaterials or secondary compounds in the Bajakah Tampala plant has an important influence on humans. Significantly, in its use as a solution to problems that often occur in health. Biofilm growth on catheters is associated with urinary tract nosocomial infections and causes an increase in mortality every year worldwide. Urinary catheters are a significant factor in CAUTI, with 70 to 80% of infections currently attributable to biofilms. Bajakah Tampala is a native plant of Kalimantan, which has antibacterial activity, but no one has reported its antibiofilm activity.\u0000\u0000\u0000\u0000The effectiveness of the Bajakah Tampala antibiofilm against polymicrobial biofilms was analyzed by calculating the minimum biofilm inhibitor concentration (MBIC50) and the minimum biofilm eradication concentration (MBEC50).\u0000\u0000\u0000\u0000Flavonoid, alkaloids, and terpenoids compounds are nanomaterials that play an essential role in Bajakah Tampala, where the ethanol extract of Bajakah Tampala has antibacterial and antifungal activity. The ethanol extract of Bajakah Tampala also had antibiofilm activity against mono-species S. aureus, E. coli, and C. albicans in the middle phase (24 hours). It exerted activity against polymicrobial biofilms on the catheter in the middle (24 hours) and maturation phases (48 hours). The results also provide evidence that Bajakah Tampala ethanol extract can eradicate polymicrobial biofilms on catheters.\u0000\u0000\u0000\u0000Therefore, Bajakah Tampala can be developed as a candidate for a new antibiofilm agent against polymicrobial biofilms with a nanoparticle approach.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45026302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-06DOI: 10.2174/2405461507666220606164446
Iti Chauhan, Lubhan Singh
Lipid nanocarriers are reaching new heights in the field of drug delivery. The core of this technology resides in simple molecules i.e. lipids. Solid and liquid lipids of biocompatible and generally recognized as safe (GRAS) status are employed for developing lipid nanoparticles along with surfactant(s), solvents, and drug molecules. Researchers have practiced a variety of solid and liquid lipids with acceptable profiles in the formulation of lipid nanoparticles. Solid lipids like triglycerides, fatty acids, fatty alcohols, waxes, and butter have been used in designing lipid nanocarriers. The potential of various plant-based oils has also been tested in designing nanostructured lipid carriers (NLC). With the exponential advancement in lipid-based delivery systems, there exists a need for an appropriate lipid system to obtain an effective product. This review gives a brief insight into lipids which has been exploited by researchers for designing solid lipid nanoparticles (SLN) and nanostructured lipid carriers. A tabular presentation of important key points of past studies exploiting these lipids for preparing SLN/NLC is the highlight of the article.
{"title":"A comprehensive literature review of lipids used in formulation of lipid nanoparticles","authors":"Iti Chauhan, Lubhan Singh","doi":"10.2174/2405461507666220606164446","DOIUrl":"https://doi.org/10.2174/2405461507666220606164446","url":null,"abstract":"\u0000\u0000Lipid nanocarriers are reaching new heights in the field of drug delivery. The core of this technology resides in simple molecules i.e. lipids. Solid and liquid lipids of biocompatible and generally recognized as safe (GRAS) status are employed for developing lipid nanoparticles along with surfactant(s), solvents, and drug molecules. Researchers have practiced a variety of solid and liquid lipids with acceptable profiles in the formulation of lipid nanoparticles. Solid lipids like triglycerides, fatty acids, fatty alcohols, waxes, and butter have been used in designing lipid nanocarriers. The potential of various plant-based oils has also been tested in designing nanostructured lipid carriers (NLC). With the exponential advancement in lipid-based delivery systems, there exists a need for an appropriate lipid system to obtain an effective product. This review gives a brief insight into lipids which has been exploited by researchers for designing solid lipid nanoparticles (SLN) and nanostructured lipid carriers. A tabular presentation of important key points of past studies exploiting these lipids for preparing SLN/NLC is the highlight of the article.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48333873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-03DOI: 10.2174/2405461507666220603115619
Soamyaa Srivastava, J. Manjhi
Zinc oxide nanoparticles belong to the new age nanomaterials, they are being used tremendously for the advancements of biomedicine and modern therapeutic intervensions. Since, the current antimicrobial treatment methods are failing on various levels. Thus, The recent study is dedicated to synthesizing stable zinc oxide nanoparticles . Therefore, the application of zinc oxide nanoparticles as an alternative treatment option is explored. In the current research fabrication of zinc oxide nanoparticlesis carried out via the wet chemical method. To further confirm the purity and stability of the synthesized material, characterization was performed via zeta potential analysis, Thermogravimetric analysis, Differential Scanning calorimetry, Transmission Electron Microscopy and Scanning Electron Microscopy. SEM and TEM revealed the spherical structure of zinc oxide nanoparticles, also having slight agglomeration at a few points. The thermal stability was tested via thermogravimetric analysis and differential Scanning Calorimetry depicting the strength of the nanomaterial at a very high temperature. Elemental composition was evaluated using Energy Dispersive X-ray Spectroscopy showing 96.01% zinc and 3.99% oxygen, demonstrating the purity of the synthesized zinc oxide nanoparticles. It confirms that no other elements are present apart from zinc and oxygen. Zinc oxide nanoparticles were synthesized via wet chemical method using zinc nitrate and sodium hydroxide. This fabrication procedure is reliable, cheap, and yields the most stable by-products. Characterization was carried out via several analytical techniques to check the authenticity of the synthesized nanomaterial, thus revealing that the obtained ZnO nanoparticles could be used in medical interventions as a safe option.
{"title":"Surface Characterization of Zinc Oxide Nanoparticles Synthesized Via Chemical Route.","authors":"Soamyaa Srivastava, J. Manjhi","doi":"10.2174/2405461507666220603115619","DOIUrl":"https://doi.org/10.2174/2405461507666220603115619","url":null,"abstract":"\u0000\u0000Zinc oxide nanoparticles belong to the new age nanomaterials, they are being used tremendously for the advancements of biomedicine and modern therapeutic intervensions.\u0000\u0000\u0000\u0000Since, the current antimicrobial treatment methods are failing on various levels. Thus, The recent study is dedicated to synthesizing stable zinc oxide nanoparticles . Therefore, the application of zinc oxide nanoparticles as an alternative treatment option is explored.\u0000\u0000\u0000\u0000In the current research fabrication of zinc oxide nanoparticlesis carried out via the wet chemical method. To further confirm the purity and stability of the synthesized material, characterization was performed via zeta potential analysis, Thermogravimetric analysis, Differential Scanning calorimetry, Transmission Electron Microscopy and Scanning Electron Microscopy.\u0000\u0000\u0000\u0000SEM and TEM revealed the spherical structure of zinc oxide nanoparticles, also having slight agglomeration at a few points. The thermal stability was tested via thermogravimetric analysis and differential Scanning Calorimetry depicting the strength of the nanomaterial at a very high temperature. Elemental composition was evaluated using Energy Dispersive X-ray Spectroscopy showing 96.01% zinc and 3.99% oxygen, demonstrating the purity of the synthesized zinc oxide nanoparticles. It confirms that no other elements are present apart from zinc and oxygen.\u0000\u0000\u0000\u0000Zinc oxide nanoparticles were synthesized via wet chemical method using zinc nitrate and sodium hydroxide. This fabrication procedure is reliable, cheap, and yields the most stable by-products. Characterization was carried out via several analytical techniques to check the authenticity of the synthesized nanomaterial, thus revealing that the obtained ZnO nanoparticles could be used in medical interventions as a safe option.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44398764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-31DOI: 10.2174/2405461507666220531111906
Bunu Khatiwara, Simran Singh, Samarpan Sarangi, Arnab Das, Jigyasha Dhakal, P. Chakraborty
Green synthesis of nanoparticles is an emerging topic with many significant applications in environmental and biomedical fields. The main aim of green synthesis is the development of eco-friendly nanoparticles using biological materials like plants and microbes and thus, reducing the practice of utilizing toxic substances. Different plant-derived materials are regularly utilized to synthesise sustainable nanoparticles with almost comparable properties yet utilize less hazardous manufacturing processes. This review aims to update these green synthetic processes for developing nanoparticles.
{"title":"Application of Plant Extracts for the Synthesis of Nanoparticles in Green Chemistry: A Concise Update","authors":"Bunu Khatiwara, Simran Singh, Samarpan Sarangi, Arnab Das, Jigyasha Dhakal, P. Chakraborty","doi":"10.2174/2405461507666220531111906","DOIUrl":"https://doi.org/10.2174/2405461507666220531111906","url":null,"abstract":"\u0000\u0000Green synthesis of nanoparticles is an emerging topic with many significant applications in environmental and biomedical fields. The main aim of green synthesis is the development of eco-friendly nanoparticles using biological materials like plants and microbes and thus, reducing the practice of utilizing toxic substances. Different plant-derived materials are regularly utilized to synthesise sustainable nanoparticles with almost comparable properties yet utilize less hazardous manufacturing processes. This review aims to update these green synthetic processes for developing nanoparticles.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46050549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-20DOI: 10.2174/2405461507666220520153752
Bekan Bogale, Tsegaye Girma Asere, Tilahun Yai, F. Melak
To study photocatalytic degradation of methylene blue dye on cuprous oxide/graphene nanocomposite. Cuprous oxide (Cu2O) nanoparticles are among the metal oxides that demonstrated photocatalytic activity. However, the stability of Cu2O nanoparticles due to the fast recombination rate of electron/hole pairs remains a significant challenge in their photocatalytic applications. This in turn leads to mismatching of the effective bandgap separation, tending to reduce the photocatalytic activity of the desired organic waste (MB). To overcome these limitations, graphene has been added to make nanocomposites with cuprous oxides. In this study, Cu2O/graphene nanocomposite was synthesized and evaluated for its photocatalytic performance of methylene blue (MB) dye degradation. :Cu2O/graphene nanocomposites were synthesized from graphite powder and copper nitrate using facile sol-gel method. Batch experiments have been conducted to assess the applications of the nanocomposites for MB degradation. Parameters such as contact time, catalyst dosage, and pH of the solution were optimized for maximum MB degradation. The prepared nanocomposites were characterized by using UV-Vis, FTIR, XRD, and SEM. The photocatalytic performance of Cu2O/graphene nanocomposites were compared against Cu2O nanoparticles for cationic MB dye degradation. Cu2O/graphene nanocomposite exhibits higher photocatalytic activity for MB degradation (with a degradation efficiency of 94%) than pure Cu2O nanoparticle (67%).This has been accomplished after 180 min of irradiation under visible light. The kinetics of MB degradation by Cu2O/graphene composites can be demonstrated by the second-order kinetic model. The synthesized nanocomposite can be used for more than three cycles of phtocatalytic MB degradation. This work indicated new insights into Cu2O/graphene nanocomposite as high-performance in photocatalysis to degrade MB, playing a great role in environmental protection in relation to MB dye.
{"title":"Photocatalytic degradation of methylene blue dye using cuprous oxide/graphene nanocomposite","authors":"Bekan Bogale, Tsegaye Girma Asere, Tilahun Yai, F. Melak","doi":"10.2174/2405461507666220520153752","DOIUrl":"https://doi.org/10.2174/2405461507666220520153752","url":null,"abstract":"\u0000\u0000To study photocatalytic degradation of methylene blue dye on cuprous oxide/graphene nanocomposite.\u0000\u0000\u0000\u0000Cuprous oxide (Cu2O) nanoparticles are among the metal oxides that demonstrated photocatalytic activity. However, the stability of Cu2O nanoparticles due to the fast recombination rate of electron/hole pairs remains a significant challenge in their photocatalytic applications. This in turn leads to mismatching of the effective bandgap separation, tending to reduce the photocatalytic activity of the desired organic waste (MB). To overcome these limitations, graphene has been added to make nanocomposites with cuprous oxides.\u0000\u0000\u0000\u0000In this study, Cu2O/graphene nanocomposite was synthesized and evaluated for its photocatalytic performance of methylene blue (MB) dye degradation.\u0000\u0000\u0000\u0000:Cu2O/graphene nanocomposites were synthesized from graphite powder and copper nitrate using facile sol-gel method. Batch experiments have been conducted to assess the applications of the nanocomposites for MB degradation. Parameters such as contact time, catalyst dosage, and pH of the solution were optimized for maximum MB degradation. The prepared nanocomposites were characterized by using UV-Vis, FTIR, XRD, and SEM. The photocatalytic performance of Cu2O/graphene nanocomposites were compared against Cu2O nanoparticles for cationic MB dye degradation.\u0000\u0000\u0000\u0000Cu2O/graphene nanocomposite exhibits higher photocatalytic activity for MB degradation (with a degradation efficiency of 94%) than pure Cu2O nanoparticle (67%).This has been accomplished after 180 min of irradiation under visible light. The kinetics of MB degradation by Cu2O/graphene composites can be demonstrated by the second-order kinetic model. The synthesized nanocomposite can be used for more than three cycles of phtocatalytic MB degradation.\u0000\u0000\u0000\u0000This work indicated new insights into Cu2O/graphene nanocomposite as high-performance in photocatalysis to degrade MB, playing a great role in environmental protection in relation to MB dye.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48256582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-16DOI: 10.2174/2405461507666220516093922
S. Balamurugan, N. Giribha, S. A. Ashika
Amongst the different spinel cobaltites investigated to date, the FeCo2O4 phase has been relatively less studied in detail despite the potential applications in several areas. As the nanostructured spinels are sensitive to the processing conditions, we have extended our research interest in FeCo2O4 phase materials. (i)To synthesize the FeCo2O4 nanomaterials by different approaches using different precursors and (ii) To investigate the structural, thermal, optical, and micro-structural properties of different materials by various characterization techniques. Different approaches such as hexamine-assisted combustion synthesis, co-precipitation, and solvothermal methods were employed to obtain FeCo2O4 nanomaterials using different precursors. The XRD pattern of the as-prepared product of the solvothermal method is significantly different from other processed as-prepared products. The annealed FeCo2O4 materials obtained by co-precipitation using nitrates and/or chlorides showed nearly a single phase of FeCo2O4 nanomaterials. The phase formation of FeCo2O4 materials is sensitive to the presently employed synthesis conditions. The XRD patterns confirmed the deficient crystalline nature of the as-prepared materials produced by sol-gel combustion and co-precipitation methods. The annealed materials obtained by the co-precipitation using nitrates and chlorides showed nearly a singleFeCo2O4 phase. The observed particle sizes of the FeCo2O4 phase materials are octahedral shaped with different sizes of 89 to 344 nm. The optical property studied using the FT-IR technique shows IR bands at 500 ~ 630 cm-1.
{"title":"Octahedron-shaped nano FeCo2O4 phase materials: Wet chemical synthesis and characterization studies","authors":"S. Balamurugan, N. Giribha, S. A. Ashika","doi":"10.2174/2405461507666220516093922","DOIUrl":"https://doi.org/10.2174/2405461507666220516093922","url":null,"abstract":"\u0000\u0000Amongst the different spinel cobaltites investigated to date, the FeCo2O4 phase has been relatively less studied in detail despite the potential applications in several areas. As the nanostructured spinels are sensitive to the processing conditions, we have extended our research interest in FeCo2O4 phase materials.\u0000\u0000\u0000\u0000(i)To synthesize the FeCo2O4 nanomaterials by different approaches using different precursors and (ii) To investigate the structural, thermal, optical, and micro-structural properties of different materials by various characterization techniques.\u0000\u0000\u0000\u0000Different approaches such as hexamine-assisted combustion synthesis, co-precipitation, and solvothermal methods were employed to obtain FeCo2O4 nanomaterials using different precursors.\u0000\u0000\u0000\u0000The XRD pattern of the as-prepared product of the solvothermal method is significantly different from other processed as-prepared products. The annealed FeCo2O4 materials obtained by co-precipitation using nitrates and/or chlorides showed nearly a single phase of FeCo2O4 nanomaterials.\u0000\u0000\u0000\u0000The phase formation of FeCo2O4 materials is sensitive to the presently employed synthesis conditions. The XRD patterns confirmed the deficient crystalline nature of the as-prepared materials produced by sol-gel combustion and co-precipitation methods. The annealed materials obtained by the co-precipitation using nitrates and chlorides showed nearly a singleFeCo2O4 phase. The observed particle sizes of the FeCo2O4 phase materials are octahedral shaped with different sizes of 89 to 344 nm. The optical property studied using the FT-IR technique shows IR bands at 500 ~ 630 cm-1.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45116843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-16DOI: 10.2174/2405461507666220516092814
S. Rakshit, P. Jana, T. Kamilya
In recent years, the green synthesis of different metal nanoparticles has become a substantial technique for the synthesis of different essential nanoparticles and their potential applications in technological, industrial along with biomedical fields. Among the several essential nanoparticles, copper nanoparticles (CuNPs) have been attracted enormous attention for their wide range of applications like production of gas sensors, solar cells, high temperature superconductors as well as drug delivery materials and catalysis owing to its distinctive optical, electrical, dielectric, imaging and catalytic, etc. properties. Herein, in this review, our aim is to find out the recent progress of synthesis as well as different optical and structural characterizations of green synthesized CuNPs along with their broad-spectrum biomedical applications, mainly antibacterial, antifungal, antiviral and anticancer as well as the future perspective of research trends in the green synthesis of CuNPs. CuNPs have been synthesized by different researchers using three methods, namely, physical, chemical, and biological. In this review, the eco-friendly, efficient and low cost different established biological/green synthesis methods of CuNPs using different plant extracts like leaves, flowers, fruits, seeds, latex, etc., as capping and reducing agents have been briefly discussed along with reaction conditions together with their optical as well as structural analysis. Effects of different parameters on the green synthesis of CuNPs like presence of phytochemicals and confirmation of phytochemicals, temperperature, pH, etc. are elucidated. Studies of the antibacterial activity of biomolecules capped CuNPs by different researchers against both Gram positive and Gram-negative bacterial strains along with minimum inhibitory concentration (MIC) values have been summarized. Furthermore, antifungal and antiviral effects of green synthesized CuNPs studied by different researchers are mentioned with minimum inhibitory concentration (MIC) values. The anticancer activity of green synthesized CuNPs against different cancer cells that studied by different researchers are summarized with corellation sizes of CuNPs on anticancer activity. The review also focuses on in vivo applications of green synthesized CuNPs along with clinical trails. Furthermore, an emphasis is given on effectiveness of CuNPs to combating COVID-19.
{"title":"Green Synthesis of Copper Nanoparticles by using Plant Extracts and their Biomedical Applications – An Extensive Review","authors":"S. Rakshit, P. Jana, T. Kamilya","doi":"10.2174/2405461507666220516092814","DOIUrl":"https://doi.org/10.2174/2405461507666220516092814","url":null,"abstract":"\u0000\u0000In recent years, the green synthesis of different metal nanoparticles has become a substantial technique for the synthesis of different essential nanoparticles and their potential applications in technological, industrial along with biomedical fields. Among the several essential nanoparticles, copper nanoparticles (CuNPs) have been attracted enormous attention for their wide range of applications like production of gas sensors, solar cells, high temperature superconductors as well as drug delivery materials and catalysis owing to its distinctive optical, electrical, dielectric, imaging and catalytic, etc. properties. Herein, in this review, our aim is to find out the recent progress of synthesis as well as different optical and structural characterizations of green synthesized CuNPs along with their broad-spectrum biomedical applications, mainly antibacterial, antifungal, antiviral and anticancer as well as the future perspective of research trends in the green synthesis of CuNPs. CuNPs have been synthesized by different researchers using three methods, namely, physical, chemical, and biological. In this review, the eco-friendly, efficient and low cost different established biological/green synthesis methods of CuNPs using different plant extracts like leaves, flowers, fruits, seeds, latex, etc., as capping and reducing agents have been briefly discussed along with reaction conditions together with their optical as well as structural analysis. Effects of different parameters on the green synthesis of CuNPs like presence of phytochemicals and confirmation of phytochemicals, temperperature, pH, etc. are elucidated. Studies of the antibacterial activity of biomolecules capped CuNPs by different researchers against both Gram positive and Gram-negative bacterial strains along with minimum inhibitory concentration (MIC) values have been summarized. Furthermore, antifungal and antiviral effects of green synthesized CuNPs studied by different researchers are mentioned with minimum inhibitory concentration (MIC) values. The anticancer activity of green synthesized CuNPs against different cancer cells that studied by different researchers are summarized with corellation sizes of CuNPs on anticancer activity. The review also focuses on in vivo applications of green synthesized CuNPs along with clinical trails. Furthermore, an emphasis is given on effectiveness of CuNPs to combating COVID-19.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45830297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-16DOI: 10.2174/2405461507666220516152840
Ameen Abdelrahman, F. Erchiqui, B. M. Nedil
In that work, we get to enhance the unique conductive of imidazole from (>1 × 10−5 S cm−1 to 1.2 × 10−4 S•cm−1 using Graphene and grafting silver and copper Nano metals, which it worked as active sites and charge transfer based on Graphene barrier. Studying the electrochemical behaviors and reaction mechanism using cycle voltammetry (CVT) electrochemical technique. Results: It was reported multiple electrochemical reaction (redox) series between imidazole and their complex, in order to justify the imidazole complex. We conduct various characterization like EIS, Raman, FTIR, 1HNMR, and particle size analyzer has been performed to imidazole and their composite mixture to evaluated the conductive solution to be ready in future work as an application for the fluidic antenna device.
在这项工作中，我们利用石墨烯和接枝银和铜纳米金属，将咪唑的独特导电性从（>1×10−5 S cm−1）提高到1.2×10−4 S•cm−1，并将其作为活性位点和基于石墨烯势垒的电荷转移。结果：报道了咪唑与其配合物之间的多重电化学反应（氧化还原）系列，以证明咪唑配合物的合理性。我们进行了各种表征，如EIS、拉曼光谱、FTIR、1HNMR，并对咪唑及其复合混合物进行了粒度分析仪，以评估导电溶液在未来工作中作为流体天线设备的应用。
{"title":"Integrated Matrix Incorporating Imidazole Graphene Assembled Metallic Copper and Silver Nano particles to be applicable Future Fluidic Antenna device","authors":"Ameen Abdelrahman, F. Erchiqui, B. M. Nedil","doi":"10.2174/2405461507666220516152840","DOIUrl":"https://doi.org/10.2174/2405461507666220516152840","url":null,"abstract":"\u0000\u0000In that work, we get to enhance the unique conductive of imidazole from (>1 × 10−5 S cm−1 to 1.2 × 10−4 S•cm−1 using Graphene and grafting silver and copper Nano metals, which it worked as active sites and charge transfer based on Graphene barrier.\u0000\u0000\u0000\u0000Studying the electrochemical behaviors and reaction mechanism using cycle voltammetry (CVT) electrochemical technique.\u0000\u0000\u0000\u0000Results: It was reported multiple electrochemical reaction (redox) series between imidazole and their complex, in order to justify the imidazole complex.\u0000\u0000\u0000\u0000We conduct various characterization like EIS, Raman, FTIR, 1HNMR, and particle size analyzer has been performed to imidazole and their composite mixture to evaluated the conductive solution to be ready in future work as an application for the fluidic antenna device.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46473787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-16DOI: 10.2174/2405461507666220516154332
V. Patel, Unnati Joshi, Anand A. Joshi
The aim of this study was to evaluate the mechanical properties of polymer nanocomposites (PNCs) reinforced with multiwalled carbon nanotubes (MWCNT). Mixing MWCNT into the polymer at very small propositions can enrich the mechanical properties of the polymer nanocomposites. Testing Specimen fabricated with 0.1wt%, 0.5wt%, 1wt% mixing ratios using extrusion and injection molding process. Computational analysis was performed through the square RVE model and analyzed with finite element analysis (FEA) using DIGIMAT simulation tool. The specimen was evaluated by ASTM D3039 for tensile strength and ASTM D7264 for flexural. The simulated results were compared with experimental results. Scanning electron microscopy(SEM) was performed to evaluate the dispersion state of nanotubes in the matrix. The impactful improvement in mechanical properties is shown in the results after addition of functionalized MWCNTs (f-MWCNT) compared to pure polymer and non- functionalized MWCNT composites.
{"title":"Investigating the effect of hydroxyl functionalised MWCNT on the mechanical properties of PMMA based polymer nanocomposites","authors":"V. Patel, Unnati Joshi, Anand A. Joshi","doi":"10.2174/2405461507666220516154332","DOIUrl":"https://doi.org/10.2174/2405461507666220516154332","url":null,"abstract":"\u0000\u0000The aim of this study was to evaluate the mechanical properties of polymer nanocomposites (PNCs) reinforced with multiwalled carbon nanotubes (MWCNT).\u0000\u0000\u0000\u0000Mixing MWCNT into the polymer at very small propositions can enrich the mechanical properties of the polymer nanocomposites. Testing Specimen fabricated with 0.1wt%, 0.5wt%, 1wt% mixing ratios using extrusion and injection molding process. Computational analysis was performed through the square RVE model and analyzed with finite element analysis (FEA) using DIGIMAT simulation tool. The specimen was evaluated by ASTM D3039 for tensile strength and ASTM D7264 for flexural.\u0000\u0000\u0000\u0000The simulated results were compared with experimental results. Scanning electron microscopy(SEM) was performed to evaluate the dispersion state of nanotubes in the matrix.\u0000\u0000\u0000\u0000The impactful improvement in mechanical properties is shown in the results after addition of functionalized MWCNTs (f-MWCNT) compared to pure polymer and non- functionalized MWCNT composites.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46152606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-28DOI: 10.2174/2405461507666220428121823
Ayesha Siddiqua Gazi, A. Krishnasailaja
The aim of this study was to develop and characterize Methotrexate loadedsolid lipid nanoparticles by Micro emulsion technique. Methotrexate is a preferable anti metabolite drug. It is used in the treatment of certain cancers like breast cancer, skin and lung cancer. Clinical studies have revealed that the curative effect of MTX tablet regarding cancers was limited due to its toxic dose-related side effects to normal cells, nephrotoxicity, and bone marrow suppression, acute and chronic hepatotoxicity and also due to the drug resistance of the tumour cells. Hence, there is a need to develop methotrexate solid lipid nanoparticles in order to minimize the adverse effects associated with the MTX tablet dosage form. -The objective of the research work is to formulate, characterize and evaluate Methotrexate solid lipid nanoparticles by micro emulsification solidification technique. Solid lipid nanoparticles prepared by using lipids stearic acid and glycerol monostearate by varying the concentration of surfactant. Three formulations were prepared with each lipid. Micro emulsion technique was adopted for preparation of solid lipid nanoparticles. Each formulation was evaluated for drug content, entrapment efficiency, loading capacity& invitro drug release studies. Both the lipids were compared for the characterization and evaluation parameters. On comparison Glycerol monostearate was found to be a better lipid over Stearic acid for the preparation of Methotrexate solid lipid nanoparticles because of its smaller mean particle diameter (238.8 nm), higher stability (-56.5 mV) and greater entrapment efficiency. Methotrexate solid lipid nanoparticles were successfully prepared with higher stability and drug release rate.
{"title":"FORMULATION OF METHOTREXATE LOADED SOLID LIPID NANOPARTICLES BY MICRO EMULSION TECHNIQUE","authors":"Ayesha Siddiqua Gazi, A. Krishnasailaja","doi":"10.2174/2405461507666220428121823","DOIUrl":"https://doi.org/10.2174/2405461507666220428121823","url":null,"abstract":"\u0000\u0000The aim of this study was to develop and characterize Methotrexate loadedsolid lipid nanoparticles by Micro emulsion technique.\u0000\u0000\u0000\u0000Methotrexate is a preferable anti metabolite drug. It is used in the treatment of certain cancers like breast cancer, skin and lung cancer. Clinical studies have revealed that the curative effect of MTX tablet regarding cancers was limited due to its toxic dose-related side effects to normal cells, nephrotoxicity, and bone marrow suppression, acute and chronic hepatotoxicity and also due to the drug resistance of the tumour cells. Hence, there is a need to develop methotrexate solid lipid nanoparticles in order to minimize the adverse effects associated with the MTX tablet dosage form.\u0000\u0000\u0000\u0000-The objective of the research work is to formulate, characterize and evaluate Methotrexate solid lipid nanoparticles by micro emulsification solidification technique.\u0000\u0000\u0000\u0000Solid lipid nanoparticles prepared by using lipids stearic acid and glycerol monostearate by varying the concentration of surfactant. Three formulations were prepared with each lipid. Micro emulsion technique was adopted for preparation of solid lipid nanoparticles. Each formulation was evaluated for drug content, entrapment efficiency, loading capacity& invitro drug release studies. Both the lipids were compared for the characterization and evaluation parameters.\u0000\u0000\u0000\u0000On comparison Glycerol monostearate was found to be a better lipid over Stearic acid for the preparation of Methotrexate solid lipid nanoparticles because of its smaller mean particle diameter (238.8 nm), higher stability (-56.5 mV) and greater entrapment efficiency.\u0000\u0000\u0000\u0000Methotrexate solid lipid nanoparticles were successfully prepared with higher stability and drug release rate.\u0000","PeriodicalId":10924,"journal":{"name":"Current Nanomaterials","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48368286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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