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Evaluating the Antidepressant-like Properties of Melatonin and Vitamin D3 Combination in Mice Subjected to Restraint Stress: Investigating the Involvement of Oxidative Stress 褪黑激素和维生素D3联合应用对约束应激小鼠抗抑郁作用的评价:氧化应激参与的研究
IF 0.6 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-08-11 DOI: 10.2174/1574885518666230811121026
A. Hosseinzadeh, S. Mehrzadi, A. Hosseini, S. Hassani, Fahimeh Azimirad
Increased levels of oxidative stress are connected with depression. Due to the melatonin's antioxidant effects and vitamin D3 (Vit D3)'s regulatory effect on the biosynthesis of neurotransmitters and neurotrophic factors, the present study investigated the possible protective effect of melatonin and Vit D3 combination on restraint stress-induced depression-like behaviors in mice.After being subjected to restraint stress, mice were divided into six groups using a randomization process. These groups included non-stressed and stressed vehicle-treated groups, as well as groups treated with Vit D3 (25 μg/kg/day), melatonin (10 mg/kg) or fluoxetine. A group also received a combination of both melatonin and Vit D3. The forced swimming test (FST), and open field test (OFT) were conducted to evaluate behavioural changes. The malondialdehyde (MDA) level and catalase (CAT), superoxide dismutase (SOD) activity, and ADP/ATP ratio were evaluated in the hippocampus of mice.Restraint stress lengthened the immobility period in FST, while melatonin, Vit D3, and their combination all significantly reversed this impact. Co-administration of melatonin and Vit D3 was more effective than melatonin or Vit D3 administration alone at reducing immobility time. The exposure of mice to restraint stress has been linked to an elevation in the ADP/ATP ratio and oxidative stress in their hippocampus; however, these effects are reversed by the administration of melatonin and Vit D3 (10 mg/kg) alone or in combination. Melatonin and Vit D3 combination increased the hippocampus CAT activity compared with melatonin and Vit D3 alone.The current study's findings suggested that Vit D3 may enhance melatonin's potential as an antidepressant in FST.
氧化应激水平的升高与抑郁症有关。由于褪黑素的抗氧化作用和维生素D3(Vit D3)对神经递质和神经营养因子生物合成的调节作用,本研究探讨了褪黑素和Vit D3组合对小鼠约束应激诱导的抑郁样行为的可能保护作用。在受到约束应激后,使用随机化过程将小鼠分为六组。这些组包括非应激组和应激载体治疗组,以及维生素D3治疗组(25 μg/kg/天)、褪黑素(10mg/kg)或氟西汀。一组还接受了褪黑素和维生素D3的组合。进行强迫游泳测试(FST)和开放场地测试(OFT)来评估行为变化。测定小鼠海马丙二醛(MDA)水平、过氧化氢酶(CAT)、超氧化物歧化酶(SOD)活性和ADP/ATP比值。约束应激延长了FST的不动期,而褪黑素、维生素D3及其组合都显著逆转了这种影响。褪黑素和维生素D3的联合给药在减少静止时间方面比褪黑素或单独给药维生素D3更有效。小鼠暴露于约束应激与其海马中ADP/ATP比率和氧化应激的升高有关;然而,通过单独或组合施用褪黑素和维生素D3(10mg/kg)来逆转这些作用。与单独使用褪黑素和维生素D3相比,褪黑激素和维生素D3组合增加了海马CAT活性。目前的研究结果表明,维生素D3可能增强褪黑激素作为FST抗抑郁药的潜力。
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引用次数: 0
Dietary Phytoactives in the Management of Gastric Cancer -A Mini Review 饮食中的植物活性物质在癌症治疗中的应用——综述
IF 0.6 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-08-09 DOI: 10.2174/1574885518666230809121536
Vivek Sharma, M. Ashawat, Pravin Kumar
Gastric cancer is the fourth leading cause of morbidity worldwide and is known to affect various gastric organs, including the esophagus, intestine, colon, and pancreas. There are variable factors responsible for the development of gastric tumors, such as environmental factors, EPV, hepatitis B and C, and other genetic factors. Phytoactives, or secondary metabolites of plants, have a wide range of biological impacts, including the capacity to prevent cancer in humans. They have this anti-cancerous impact because of their multi-target mechanism of action, which also includes antioxidant, anti-proliferative, cell apoptosis, and anti-mutagenic effects. To epitomize the role of vital dietary phytoactives as a new approach for treating gastric cancer and explains various mechanisms for their anti-cancerous activity. H. pylori-associated gastric tumors are the most common, and Phytoactives such as curcumin, piperine, walnut oil, tea, and others possess anticancer properties. They have shown anticancer activity against gastric tumor cell lines via different mechanisms like cell cycle arrest, apoptosis, inhibition of cell proliferation, adhesion, colonization of cancer cells, inhibition of inflammatory mediators, tumor cell bioenergetics, up and down-regulation of various gene and protein expression, and chelation and scavenging of ROS.
胃癌是世界上第四大致病原因,已知会影响胃的各个器官,包括食道、肠、结肠和胰腺。胃肿瘤的发生有多种因素,如环境因素、EPV、乙肝和丙肝,以及其他遗传因素。植物活性物质或植物的次生代谢产物具有广泛的生物学影响,包括预防人类癌症的能力。它们具有这种抗癌作用是因为它们的多靶点作用机制,包括抗氧化、抗增殖、细胞凋亡和抗诱变作用。概述重要膳食植物活性物质作为治疗胃癌新途径的作用,并解释其抗癌作用的各种机制。幽门螺杆菌相关的胃肿瘤是最常见的,而姜黄素、胡椒碱、核桃油、茶等植物活性物质具有抗癌特性。它们通过细胞周期阻滞、细胞凋亡、抑制细胞增殖、粘附、癌细胞定植、抑制炎症介质、肿瘤细胞生物能量、上调和下调各种基因和蛋白表达、螯合和清除活性氧等不同机制对胃肿瘤细胞系显示出抗癌活性。
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引用次数: 0
Preclinical Appraisal of the aphrodisiac effects of Emblica officinalis seed extract on stress-induced sexual behavior in albino rats 榆子提取物对白化大鼠应激性行为壮阳作用的临床前评价
IF 0.6 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-08-04 DOI: 10.2174/1574885518666230804113303
D. Khobragade, Sunil Kumar Kadiri, Samaresh Pal Roy
The king of herbs, Emblica officinalis, is one of the most important herbs in Ayurveda. It contains significant amounts of Vitamin C and has been reported to have antioxidant, anticancer, antiretroviral, antidepressant, antiulcerogenic, wound healing, and many other medicinal propertiesThe current study is designed to investigate the aphrodisiac effects of E.officinalis seed extract on albino Wistar rats as well as its effects on stress-related sexual behaviour.The aphrodisiac effect of E. officinalis was evaluated by mating the pretreated male rats with female rats. For 30 days, test group rats (n=6) were given methanolic extracts (95%) from E.officinalis seeds (500 and 1000 mg/kg). Control rats received saline. Standard group rats received testosterone (0.5 mg/ kg, i.m). The sexual behavior study tracked mount latency (ML), intromission latency (IL), mounting frequency (MF), intromission frequency (IF), sniffing, and licking on days 0 through 30. After 30 days, rats were sacrificed, and the anabolic effect was assessed using body weight, reproductive organ weight, sperm concentration, and histopathology of the testes. The stress was induced by immobilization stress in the stress-affected alteration in the sexual behavior model, and the above procedure was repeated for evaluation.The 95% methanolic extract (1000 mg/kg) of E. officinalis significantly reduced ML and IL while significantly increasing MF, IF, sniffing, licking, body weight, reproductive organ weight, and sperm concentration. Methanolic extract of E. officinalis increased sexual activities in the stress-free group and restored the stress-affected group's altered sexual behaviour.The current study's findings indicate that 95% methanolic extract of E. officinalis has dose-dependent aphrodisiac activity and restores sexual behavior in a stress-induced group.
草药之王,Emblica officinalis,是阿育吠陀最重要的草药之一。它含有大量的维生素C,据报道具有抗氧化、抗癌、抗逆转录病毒、抗抑郁、抗溃疡、伤口愈合和许多其他药用特性。目前的研究旨在调查officinalis种子提取物对白化Wistar大鼠的壮阳作用,以及它对压力相关性行为的影响。通过将预处理后的雄性大鼠与雌性大鼠交配来评价officinalis的壮阳作用。试验组大鼠(n=6)连续30 d,分别给予马齿苋种子甲醇提取物(95%)500、1000 mg/kg。对照组大鼠接受生理盐水。标准组大鼠给予睾酮0.5 mg/ kg, ig。性行为研究从第0天到第30天,追踪了上马潜伏期(ML)、进宫潜伏期(IL)、上马频率(MF)、进宫频率(IF)、嗅探和舔舐。30 d后处死大鼠,通过体重、生殖器官重量、精子浓度和睾丸组织病理学来评估合成代谢效果。在性行为模型的应力影响改变中,采用固定应力诱导应激,并重复上述过程进行评价。95%甲醇提取物(1000 mg/kg)显著降低ML和IL,显著增加MF、IF、嗅、舔、体重、生殖器官重量和精子浓度。officinalis甲醇提取物增加了无压力组的性活动,并恢复了受压力影响组的性行为改变。目前的研究结果表明,95%的甲醇提取物具有剂量依赖性的壮阳活性,并恢复应激诱导组的性行为。
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引用次数: 0
Preparation of Ketoconazole-Loaded Nanoemulsions for Ophthalmic Delivery: Characterization and in-vitro Antifungal Activity Evaluation 酮康唑负载纳米眼科乳剂的制备、表征及体外抗菌活性评价
IF 0.6 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-08-04 DOI: 10.2174/1574885518666230804120659
Mohammad Mehdi Mahboobian, Negin Azadi, Shabnam Pourmoslemi
Nanoemulsions (N.E.s) capable of ocular bioavailability elevation can be used for poor water-soluble drugs such as ketoconazole (K.Z.). The current investigation was designed for the purpose of overcoming this issue by developing K.Z. containing N.E.s for ophthalmic drug delivery with appropriate therapeutic efficiency.The preparation of ketoconazole N.E.s was performed by the low-energy technique. According to the phase diagram, three stable formulations were selected for more physicochemical analyses, including particle size, polydispersity index, pH, refractive index, osmolality, and viscosity. Finally, drug release patterns and in-vitro antifungal activity were assessed for the final selected formulation.The developed N.E. formulations with droplet sizes less than 20nm showed appropriate physicochemical characteristics for ocular delivery. The selected formulation released 100% of the encapsulated drug during 24 h. Moreover, antifungal assessments showed that prepared N.E. had acceptable in vitro antifungal activity.Based on our findings, it can be concluded that N.E.s could be applied as effective carriers for the ophthalmic delivery of ketoconazole.
能够提高眼部生物利用度的纳米乳液(N.E.s)可用于水溶性差的药物,如酮康唑(K.Z.)。目前的研究旨在通过开发具有适当治疗效率的含K.Z.的N.E.s用于眼科药物递送来克服这一问题。酮康唑N.E.的制备采用低能耗技术。根据相图,选择了三种稳定的配方进行更多的物理化学分析,包括粒度、多分散指数、pH、折射率、渗透压和粘度。最后,对最终选择的制剂的药物释放模式和体外抗真菌活性进行了评估。所开发的液滴尺寸小于20nm的N.E.制剂显示出适合眼部递送的物理化学特性。所选制剂在24小时内释放出100%的包封药物。此外,抗真菌评估表明,制备的N.E.具有可接受的体外抗真菌活性。根据我们的研究结果,可以得出结论,N.E.可以作为酮康唑眼科给药的有效载体。
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引用次数: 0
COVID-19 Research, Public Health, and Biomedical Basis COVID-19研究,公共卫生和生物医学基础
IF 0.6 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-08-01 DOI: 10.2174/1574885518666230801091246
Da Yong Lu, Ting Ren Lu
The coronavirus outbreak (COVID-19, SARS-CoV-2) greatly impacts the world. Despite great biomedical efforts, approximately 30-50% global population was at least once infected with COVID. Human life expectancy is reduced by COVID-19 epidemics worldwide. It is indispensable to prevent and treat COVID-19 as effectively as possible. In order to well prevent and treat the coronavirus infection, clinical diagnostic or therapeutic paradigms should be updated. Since the outside condition of COVID-19 prevention is imbalanced among regions and countries, global prevention and treatment action should be aimed. Despite global vaccination for COVID, a significant proportion of humans still constantly exposes and infected with viruses. Advanced viral biological knowledge and vaccine techniques can alleviate viral spread and promote therapeutics. Universal and specific preventive and treatment paradigms should be designed, integrated, and introduced. The origin and hidden nature of COVID-19 biology and pathogenesis are broadly understood now. Viral vaccines, pathogenesis, diagnosis, treatment, and personalized medicine are progressing rapidly. Many viral vaccines and personalized medicine should be especially emphasized. To speed up global efforts against COVID-19, new knowledge and breakthroughs of viral transmissibility, vaccine technique innovation, diagnostic widening, and therapeutic variability worldwide are discussed. Different strategic platforms and landscapes can reach different outcomes. By facilitating global machinery against different variants of COVID, viral-induced socioeconomic burden and imbalance could be reduced.
新型冠状病毒疫情(COVID-19, SARS-CoV-2)对世界产生了巨大影响。尽管在生物医学方面做出了巨大努力,但全球约有30-50%的人口至少感染过一次COVID。全球范围内的COVID-19流行病降低了人类的预期寿命。尽可能有效地预防和治疗COVID-19是必不可少的。为了更好地预防和治疗冠状病毒感染,需要更新临床诊断或治疗模式。各地区、各国疫情防控的外部条件不平衡,应着眼于全球防控行动。尽管全球接种了COVID疫苗,但仍有很大一部分人不断接触和感染病毒。先进的病毒生物学知识和疫苗技术可以减轻病毒的传播,促进治疗。应该设计、整合和引入普遍和具体的预防和治疗范例。COVID-19的起源和隐蔽性、生物学和发病机制已被广泛了解。病毒疫苗、发病机制、诊断、治疗和个性化医疗正在迅速发展。许多病毒疫苗和个性化医疗应特别强调。为加快全球抗击COVID-19的努力,讨论了病毒传播的新知识和突破、疫苗技术创新、诊断范围扩大和全球治疗变异性。不同的战略平台和景观可以达到不同的结果。通过促进针对不同变体COVID的全球机制,可以减少病毒引起的社会经济负担和不平衡。
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引用次数: 0
Analysis of Research Publications on Leprosy Drugs Related Adverse Drug Reactions – A Scinetometric Study 麻风病药物相关不良反应研究报告分析——一项科学计量研究
IF 0.6 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-07-31 DOI: 10.2174/1574885518666230731090607
P. Thangaraju, Himanshu Nirmal Chandu, Hemasri Velmurugan, S. Venkatesan
Leprosy is curable and can be treated with multidrug therapy in the early stages. As a result,we chose a Scientometrics evaluation of leprosy research guides on adverse drug reactions to bettergrasp the current popularity of drug-related responses. During the 2010-2021 a study with a total of 48publications was selected. This study aims to analyze scientometric tools such as frequency distribution, percentage analysis, double-related growth rate, and interaction rate. During the study period, 7(14.58%) study publications were submitted in 2018. The related growth rate is identified by decreasing trend and the double time is growing from 2010 to 2021. The 11 published study sizes (22.92%)were provided by top writers, the average Degree of Collaboration is 0.96, and 19 (39.58%) publishedresearch articles by headers. India is the largest supplier of 21 leprosy research publications (43.75%).As India is the most productive country in leprosy research, hence there are four out of the top five institutions that are from the Indian center that is listed among the most productive institutions.
麻风病是可以治愈的,可以在早期进行多药治疗。因此,我们选择了一份科学计量学评估麻风病药物不良反应研究指南,以更好地了解当前药物相关反应的流行情况。2010-2021年期间,选择了一项共有48份出版物的研究。本研究旨在分析科学计量工具,如频率分布、百分比分析、双相关增长率和交互作用率。在研究期间,2018年提交了7份(14.58%)研究出版物。相关增长率呈下降趋势,从2010年到2021年,两倍时间在增长。11篇已发表的研究规模(22.92%)由顶尖作家提供,平均合作度为0.96,19篇(39.58%)已发表的按标题搜索文章。印度是21种麻风病研究出版物的最大供应国(43.75%)。由于印度是麻风病科研成果最丰富的国家,因此前五名中有四家机构来自印度中心,被列为最具成果的机构之一。
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引用次数: 0
A brief insight into Nanotherapeutic approaches in the management of Analgesia 浅谈纳米治疗方法在镇痛管理中的应用
IF 0.6 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-07-27 DOI: 10.2174/1574885518666230727125109
Kritika Garg, G. S. Kumar, Arunesh Soni, S. Pawar
Growing public awareness of chronic pain resulting from illness and injury has prompted pharmaceutical researchers and drug corporations to create better, more targeted painkillers. For effective pain management, prolonged analgesic medication delivery at the intended areas continues to be a major problem such as addiction, tolerance and other serious side effects, which can prolong suffering and decrease painkiller effectiveness.The present paper focuses on review of current advances in the field of pain treatment by different nanoparticles formulations of various drugs, by enhancing their pharmacokinetic factors and diminishing associated adverse effects.According to literature survey, usage of nano-carriers enables the delivery of these drugs to target locations with less systemic toxicity. Nanotechnology for varied therapeutic purposes, different analgesics have been loaded onto different nano carriers, including those that are natural, synthetic, and polymeric and proven to be beneficial in pain management.Overall, new nano based preparations and new ways to utilize existing medications in a variety of circumstances is a multimodal approach to pain relief, have resulted in recent advancements in the pharmacological management of pain.
公众对由疾病和伤害引起的慢性疼痛的意识日益增强,这促使制药研究人员和制药公司开发出更好、更有针对性的止痛药。对于有效的疼痛管理,在预期区域长时间的镇痛药物递送仍然是一个主要问题,如成瘾,耐受性和其他严重的副作用,这可以延长痛苦并降低止痛药的有效性。本文重点综述了不同药物的纳米颗粒配方,通过增强其药代动力学因子和减少相关不良反应来治疗疼痛领域的最新进展。根据文献调查,纳米载体的使用使得这些药物能够以更小的全身毒性递送到目标位置。纳米技术用于不同的治疗目的,不同的镇痛药被装载到不同的纳米载体上,包括那些天然的、合成的和聚合物的,并被证明对疼痛管理有益。总的来说,新的纳米基制剂和利用现有药物在各种情况下的新方法是缓解疼痛的多模式方法,导致了疼痛的药理学管理的最新进展。
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引用次数: 0
Intranasal drug delivery of antiviral agents - a revisit and way forward 抗病毒药物的鼻内给药——回顾和前进的方向
IF 0.6 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-07-27 DOI: 10.2174/1574885518666230727100812
S. Narayan, J. Affrald. R
Even to this date, oral drug delivery in the form of tablets, capsules, and syrups is considered as the most accepted one. However, oral delivery as a methodology requires that the active molecules and their formulations are water-soluble. Nasal drug delivery is characterized by ease of permeability through the epithelial mucosa, low enzyme activity, and a wide range of immunocompetentcells. For the transfer of drugs and active molecules through the nasal route, it is often essential to resort to nanodelivery methods, such as liposomes, microspheres, nanoemulsions, and so on. The use ofnanodelivery vehicles has become more important in the modern context of viral infections, includingthose of the respiratory tract. Nanoformulations are developed in the form of nasal gels, sprays, drops,rinses, etc. Nanoformulations of antigens, vaccine and immune adjuvants, and antivirals are now gaining importance. There are promising reports on nanoparticles of metals, metal oxides, polymers, andso on that have the potential to detect and inhibit viruses by themselves. This review looks into the nasal nanoformulations in detail and provides an insight into how their efficacy can be improved. Toovercome known drawbacks, such as degradation and active mucociliary clearance by antigenpresenting cells at the site of administration, polymers, such as PEG, are incorporated in the nanoformulation. Polymeric systems also provide better tunability of physicochemical properties. The mechanism of nasal spray-based drug delivery systems is also discussed in this paper. The review, thus, provides a detailed insight into the way forward for the development of nasal formulations.
即使到目前为止,片剂、胶囊和糖浆形式的口服药物也被认为是最受欢迎的药物。然而,口服给药作为一种方法要求活性分子及其制剂是水溶性的。鼻腔给药的特点是易于通过上皮粘膜渗透,酶活性低,免疫活性细胞范围广。对于通过鼻腔途径转移药物和活性分子,通常必须采用纳米递送方法,如脂质体、微球、纳米乳液等。在现代病毒感染(包括呼吸道感染)的背景下,纳米递送载体的使用变得更加重要。纳米制剂以鼻凝胶、喷雾剂、滴剂、冲洗剂等形式开发。抗原、疫苗和免疫佐剂以及抗病毒药物的纳米制剂现在越来越重要。关于金属、金属氧化物、聚合物等纳米颗粒有可能自行检测和抑制病毒的报道很有希望。这篇综述详细研究了鼻腔纳米制剂,并深入了解了如何提高其疗效。为了克服已知的缺点,如在给药部位抗原呈递细胞的降解和活性粘液纤毛清除,将聚合物(如PEG)掺入纳米制剂中。聚合物系统还提供了更好的物理化学性质的可调谐性。本文还讨论了基于鼻喷雾剂的药物递送系统的机理。因此,这篇综述为鼻腔制剂的发展提供了详细的见解。
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引用次数: 0
Nanobots: Revolutionizing the next generation of biomedical technology and drug therapy 纳米机器人:革新下一代生物医学技术和药物治疗
IF 0.6 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-07-26 DOI: 10.2174/1574885518666230726123433
Vandana Panda, Akash Saindane, Aditya Pandey
Nanoscale machines called “nanorobots” that were hitherto only futuristic ideas are set to storm healthcare and pharmaceuticals with newer technologies for minimally invasive diagnosis, quick and precise surgeries, and targeted drug delivery, which is challenging to achieve by conventional drug delivery systems. Nanobots can be defined as controllable nano-sized mechanical or electromechanical devices which are easily incorporated into cells and used for a variety of cellular functions like combating bacteria and viruses, disposing away dead cells/tissue at the place of a wound, cell/tissue repair and destruction of cancer cells, and also for transporting drugs to cells. Nanorobots can help avoid the untoward effects of traditional drug delivery systems and ameliorate the efficiency of drug delivery by quickly entering the desired cells without affecting other organs. With the advent of mobile communication, artificial neural networks, and Information Technology, futuristic and more advanced nanobots with artificial intelligence are in the offing. However, the challenges to this revolutionary technology are umpteen, the major concern being their interaction inside the human body. This review explicitly expounds on nanobots and their applications to medicine, biomedical research, and drug delivery.
迄今为止,被称为“纳米机器人”的纳米机器只是一种未来主义的想法,它将用微创诊断、快速精确的手术和靶向给药的新技术冲击医疗保健和制药,而传统给药系统很难实现这一点。纳米机器人可以被定义为可控的纳米尺寸机械或机电设备,这些设备可以容易地结合到细胞中,并用于各种细胞功能,如对抗细菌和病毒、处理伤口处的死细胞/组织、细胞/组织修复和破坏癌症细胞,以及将药物输送到细胞。纳米机器人可以帮助避免传统药物递送系统的不良影响,并通过快速进入所需细胞而不影响其他器官来提高药物递送效率。随着移动通信、人工神经网络和信息技术的出现,未来派和更先进的人工智能纳米机器人即将问世。然而,这项革命性技术面临着无数挑战,主要关注的是它们在人体内的相互作用。这篇综述明确阐述了纳米机器人及其在医学、生物医学研究和药物递送方面的应用。
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引用次数: 0
Trojan microparticles: A composite nanoparticle delivery system 特洛伊微粒:一种复合纳米粒子输送系统
IF 0.6 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-07-26 DOI: 10.2174/1574885518666230726142855
S. Shukla, Vinay Pandit
In recent years, microparticulate systems have drawn growing attention as a viable strategy for delivering cells, proteins, and medications to target areas. The Nanoparticles-in-Microparticles System (NiMS) is a drug delivery method that combines nano- and microparticles to deliver medications or genes to particular bodily regions with precision. A promising method for achieving dual or multiple functions inside a formulation is the development of nanoparticle-in-microparticle systems (NiMS). NiMS comprises a microparticle (M.P.) matrix and one or more nanoparticles (N.P.s). The N.P.s can be designed to provide specific functionality, such as targeted drug delivery or imaging, while the M.P. matrix can be tailored to provide sustained release or protect the N.P.s from degradation. NiMS offer several advantages over traditional formulations, including the ability to control release profiles and achieve site-specific delivery. By combining different types of N.P.s and M.P.s, it is possible to create formulations that release drugs at different rates or with different kinetics, allowing for tailored treatment regimens.Additionally, by lowering off-target effects and boosting efficacy, the site-specific targeting offered by NiMS can enhance the therapeutic index of medications. Microparticles are small, micron-sized particles that can be loaded with therapeutic agents and designed to deliver them to specific tissues in the body. The pharmaceutical sector is developing microparticulate delivery systems for oral, pulmonary, and cutaneous administration. For instance, a promising strategy for treating respiratory conditions, including asthma and chronic obstructive pulmonary disease, is the development of inhalable microparticles (COPD). Moreover, the use of microparticles for topical drug delivery is being studied, where they can be formulated into creams, gels, or patches for treating skin disorders. The composition of microparticles is crucial for successful tissue regeneration because the particles must be biocompatible and able to interact with the cells in the targeted tissue. In addition, the size and shape of the particles can affect their behavior and how they interact with cells. Chemical and biological sensors and devices, optical detectors, electronic components, and nanoscale production depend on nanostructures because they offer unique properties, such as increased surface area and enhanced reactivity, which can be exploited to create more efficient and effective devices.
近年来,微粒系统作为一种将细胞、蛋白质和药物输送到靶区的可行策略,引起了越来越多的关注。微颗粒系统中的纳米颗粒(NiMS)是一种药物递送方法,它将纳米颗粒和微米颗粒相结合,将药物或基因精确地递送到特定的身体区域。在配方中实现双重或多重功能的一种有前途的方法是开发微粒系统中的纳米颗粒(NiMS)。NiMS包括微粒(M.P.)基质和一种或多种纳米颗粒(N.P.s)。N.P.s可设计用于提供特定功能,如靶向药物递送或成像,而M.P.基质可定制用于提供持续释放或保护N.P.s免受降解。与传统配方相比,NiMS提供了几个优势,包括控制释放特性和实现位点特异性递送的能力。通过结合不同类型的N.P.s和M.P.s,可以创造出以不同速率或不同动力学释放药物的制剂,从而实现量身定制的治疗方案。此外,通过降低脱靶效应和提高疗效,NiMS提供的位点特异性靶向可以提高药物的治疗指数。微粒是微米大小的小颗粒,可以装载治疗剂,并将其输送到体内的特定组织。制药部门正在开发用于口服、肺部和皮肤给药的微粒递送系统。例如,一种治疗呼吸系统疾病(包括哮喘和慢性阻塞性肺病)的有前景的策略是开发可吸入微粒(COPD)。此外,正在研究微粒用于局部给药的用途,可以将其配制成乳膏、凝胶或贴片,用于治疗皮肤疾病。微粒的组成对于成功的组织再生至关重要,因为微粒必须具有生物相容性,并且能够与靶组织中的细胞相互作用。此外,颗粒的大小和形状会影响它们的行为以及它们如何与细胞相互作用。化学和生物传感器和设备、光学探测器、电子元件以及纳米级生产都依赖于纳米结构,因为它们具有独特的特性,如增加的表面积和增强的反应性,可以用来制造更高效的设备。
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Current Drug Therapy
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