Pub Date : 2023-06-01DOI: 10.2174/2215083810666230601144116
Geethu Balakrishnan, A. Shukla
Immunity can be defined as the ability of the human body to resist almost all types of organisms or toxins that tend to damage tissues and organs. Ayurveda, one of the oldest health sciences has its perspectives and practices on immunology delineated under the heads of Vyadhikshmatwa (tolerance against disease), Ojas (the quintessence of all bodily tissues that is responsible for natural bio-strength, vitality and immunity), Bala (strength), and Vikaravighata Bhavas (disease-resisting factors). For the present review, the materials were collected from the Ayurvedic literature, including the three major classical texts Brihatrayees Charaka Samhita, Sushruta Samhita, Ashtanga Samgraha and Ashtanga Hridaya, and their important commentaries by Chakrapani, Arunadutta, Hemadri, Indu, and Dalhana. Information from the current scientific literature, articles published in PubMed, and authentic webpages has also been incorporated into this study. Subsequently, an independent analysis of immunology from Ayurvedic classical texts is presented in this review. Ayurvedic compendia have vividly described the perspectives and practices of immunity and the promotion of disease-resisting factors. In addition to being the repository of age-old medical practices and the treasure trove of herbal drugs, the immunomodulatory effects of these disease-resisting factors hold up even when bridging with new models based on modern science and technology. Rather than being a complementary science, Ayurveda is enriched with the concepts and practices of immunology. In order to free humanity from the grip of infections, it is important to explore the standalone and integrative aspects of science now.
{"title":"The Immunology – Ayurveda Perspective","authors":"Geethu Balakrishnan, A. Shukla","doi":"10.2174/2215083810666230601144116","DOIUrl":"https://doi.org/10.2174/2215083810666230601144116","url":null,"abstract":"\u0000\u0000Immunity can be defined as the ability of the human body to resist almost all types of organisms or toxins that tend to damage tissues and organs. Ayurveda, one of the oldest health sciences has its perspectives and practices on immunology delineated under the heads of Vyadhikshmatwa (tolerance against disease), Ojas (the quintessence of all bodily tissues that is responsible for natural bio-strength, vitality and immunity), Bala (strength), and Vikaravighata Bhavas (disease-resisting factors).\u0000\u0000\u0000\u0000For the present review, the materials were collected from the Ayurvedic literature, including the three major classical texts Brihatrayees Charaka Samhita, Sushruta Samhita, Ashtanga Samgraha and Ashtanga Hridaya, and their important commentaries by Chakrapani, Arunadutta, Hemadri, Indu, and Dalhana. Information from the current scientific literature, articles published in PubMed, and authentic webpages has also been incorporated into this study. Subsequently, an independent analysis of immunology from Ayurvedic classical texts is presented in this review.\u0000\u0000\u0000\u0000Ayurvedic compendia have vividly described the perspectives and practices of immunity and the promotion of disease-resisting factors. In addition to being the repository of age-old medical practices and the treasure trove of herbal drugs, the immunomodulatory effects of these disease-resisting factors hold up even when bridging with new models based on modern science and technology.\u0000\u0000\u0000\u0000Rather than being a complementary science, Ayurveda is enriched with the concepts and practices of immunology. In order to free humanity from the grip of infections, it is important to explore the standalone and integrative aspects of science now.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42826128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-31DOI: 10.2174/2215083810666230531163053
Srikala Kamireddy, S. Sangeetha, Sreya Kosanam
Nature contains a diverse range of phytoconstituents that possess several pharmacological properties. However, the effectiveness of herbal formulations is limited due to the poor bioavailability of phytoconstituents, which makes it difficult for them to pass through the cell membrane. Phytosomes are a modern type of herbal formulation that comprises therapeutically active phytoconstituents extracted from medicinal plants and enclosed by phospholipids. By combining phytoconstituents with phospholipids, phytosomes are able to enhance bioavailability and reduce side effects. Various techniques such as solvent evaporation, rotatory evaporation, anti-solvent precipitation, freeze-drying, and solvent ether injection can be used to prepare phytosomes. Phytosomes can be evaluated using methods such as UV-Spectra, DSC, drug entrapment and loading capacity, surface tension activity measurement, and in-vitro/in-vivo studies. This review discusses different methods for preparing phytosomal formulations and their advantages, which have been found to significantly improve the bioavailability of phytoconstituents. Phytosomes have high entrapment efficiency and do not compromise the safety of nutrients. By utilizing phytosomal drug delivery, issues associated with conventional drug delivery may be overcome. Therefore, it is important to combine Indian Ayurvedic medicine with novel drug delivery systems to improve drug delivery technologies
{"title":"Phytosomal Drug Delivery System: A detailed study","authors":"Srikala Kamireddy, S. Sangeetha, Sreya Kosanam","doi":"10.2174/2215083810666230531163053","DOIUrl":"https://doi.org/10.2174/2215083810666230531163053","url":null,"abstract":"\u0000\u0000Nature contains a diverse range of phytoconstituents that possess several pharmacological properties. However, the effectiveness of herbal formulations is limited due to the poor bioavailability of phytoconstituents, which makes it difficult for them to pass through the cell membrane. Phytosomes are a modern type of herbal formulation that comprises therapeutically active phytoconstituents extracted from medicinal plants and enclosed by phospholipids. By combining phytoconstituents with phospholipids, phytosomes are able to enhance bioavailability and reduce side effects. Various techniques such as solvent evaporation, rotatory evaporation, anti-solvent precipitation, freeze-drying, and solvent ether injection can be used to prepare phytosomes. Phytosomes can be evaluated using methods such as UV-Spectra, DSC, drug entrapment and loading capacity, surface tension activity measurement, and in-vitro/in-vivo studies. This review discusses different methods for preparing phytosomal formulations and their advantages, which have been found to significantly improve the bioavailability of phytoconstituents. Phytosomes have high entrapment efficiency and do not compromise the safety of nutrients. By utilizing phytosomal drug delivery, issues associated with conventional drug delivery may be overcome. Therefore, it is important to combine Indian Ayurvedic medicine with novel drug delivery systems to improve drug delivery technologies\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44751968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-29DOI: 10.2174/2215083810666230529123939
R. Salari, Rahele Kargozar, H. Azizi, M. Yousefi, Seyedeh Azam Pourhoseini, Hamideh Naghedi-Baghdar, S. Ghazanfari
Menopause is a biopsychosocial phenomenon in a woman’s life, and it occurs at about the age of 48-55 years. Factors such as smoking, the number of children, early puberty, and social class can cause early natural menopause. Symptoms that occur during menopause include headache, mood disorders, insomnia, distraction, hot flashes, vaginal dryness, and sweating. The most common symptom is hot flashes, which affect 85% of women with menopause. Recently, people are showing more tendencies toward alternative therapies and herbs phytoestrogens. This review aims to introduce the mechanism of herbal phytoestrogens controlling hot flashes during menopause. Our searches were performed in the databases of PubMed, Scopus, and Cochrane. English clinical trials, that investigated the effects of phytoestrogen plants individually or in combination on the treatment of hot flashes in menopause were analyzed. After reviewing articles and meeting the inclusion and exclusion criteria, 18 articles were selected. In this study, 18 clinical trials of 2351 female patients were analyzed. The phytoestrogen plants studied include soy, red clover, cohosh, hops, flax, pomegranate, anise, and Vitex Agnus. Studies have shown the beneficial effects of phytoestrogens in controlling hot flashes, but in some cases, including soybeans, there are contradictory effects. Therefore, more clinical trials are needed to achieve reliable results to confirm the phytoestrogen effects of herbal medicines.
{"title":"Phytoestrogens in menopausal hot flashes: A review Article","authors":"R. Salari, Rahele Kargozar, H. Azizi, M. Yousefi, Seyedeh Azam Pourhoseini, Hamideh Naghedi-Baghdar, S. Ghazanfari","doi":"10.2174/2215083810666230529123939","DOIUrl":"https://doi.org/10.2174/2215083810666230529123939","url":null,"abstract":"\u0000\u0000Menopause is a biopsychosocial phenomenon in a woman’s life, and it occurs at about the age of 48-55 years. Factors such as smoking, the number of children, early puberty, and social class can cause early natural menopause. Symptoms that occur during menopause include headache, mood disorders, insomnia, distraction, hot flashes, vaginal dryness, and sweating. The most common symptom is hot flashes, which affect 85% of women with menopause. Recently, people are showing more tendencies toward alternative therapies and herbs phytoestrogens.\u0000\u0000\u0000\u0000This review aims to introduce the mechanism of herbal phytoestrogens controlling hot flashes during menopause.\u0000\u0000\u0000\u0000Our searches were performed in the databases of PubMed, Scopus, and Cochrane. English clinical trials, that investigated the effects of phytoestrogen plants individually or in combination on the treatment of hot flashes in menopause were analyzed. After reviewing articles and meeting the inclusion and exclusion criteria, 18 articles were selected.\u0000\u0000\u0000\u0000In this study, 18 clinical trials of 2351 female patients were analyzed. The phytoestrogen plants studied include soy, red clover, cohosh, hops, flax, pomegranate, anise, and Vitex Agnus.\u0000\u0000\u0000\u0000Studies have shown the beneficial effects of phytoestrogens in controlling hot flashes, but in some cases, including soybeans, there are contradictory effects. Therefore, more clinical trials are needed to achieve reliable results to confirm the phytoestrogen effects of herbal medicines.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48411175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-25DOI: 10.2174/2215083810666230525153908
R. Garg, Mona Piplani, Yogendra Pratap Singh, Pankaj Bhateja, R. Rana
Bronchial asthma is one of the most common chronic illnesses in childhood, adulthood and pregnancy with a current occurrence of 6-9 percent, but at an alarming rate of increase. Asthma is a complex genetic disorder that is heavily affected by the environment. In association with significant morbidity, quality of life, and healthcare costs, it is putting an increasing strain on our society. Some factors related to pregnancy, i.e., diet-related, antibiotic uses, and stress; childhood risk factors, i.e., lung function, exposure to smoking, animal etc. and adulthood risk factor, i.e., pollution-related etc., are responsible for trends in incidence and mortality due to asthma at a Global level and Indian population. Data were collected from PubMed, Web of Sciences, CINHAL, WHO Clinical trial register, Google Scholar, and official websites of various asthma societies and statistically analyzed using ANOVA tests. Data were analyzed for India and the specific population of the northern region of India during the last five years. Risk factors related to asthma at different stages, i.e., genetic, pregnancy, childhood, and adulthood, were reviewed, and the prevalence of asthma at the Global level, India and northern India, was analyzed and compared. The mean Global prevalence of asthma was found to be 281.3±14.7 (SD), whereas, for India, it was 22.78±8.605. After applying One Way ANOVA, a significant difference (t=48.44, df=4) was found between the Global and Indian prevalence of asthma, i.e., the mean difference of 259.7±11.99. The mean value was found highest in Delhi and Rajasthan, having values of 19.74±11.79 and 13.58±9.47, whereas Chandigarh and Uttar Pradesh recorded asthma’s prevalence as 11.87±7.83 and 4.32±2.32 respectively. Himachal and Haryana acquired almost equal values of asthma at 1.67±0.13 and 1.23±0.33.
支气管哮喘是儿童、成年和妊娠期最常见的慢性疾病之一，目前发病率为6- 9%，但正以惊人的速度增长。哮喘是一种复杂的遗传疾病，受环境影响很大。它与显著的发病率、生活质量和医疗费用有关，正给我们的社会带来越来越大的压力。与怀孕有关的一些因素，即饮食相关、抗生素使用和压力;儿童期风险因素，即肺功能、接触吸烟、接触动物等，以及成年期风险因素，即与污染有关等，是全球和印度人口哮喘发病率和死亡率趋势的原因。数据收集自PubMed、Web of Sciences、CINHAL、WHO临床试验注册、谷歌Scholar和各哮喘学会官方网站，并采用方差分析(ANOVA)进行统计分析。数据分析了印度和印度北部地区的特定人口在过去五年中。回顾了不同阶段哮喘的相关危险因素，即遗传、妊娠、儿童期和成年期，并分析和比较了全球、印度和印度北部哮喘的患病率。全球平均哮喘患病率为281.3±14.7 (SD)，而印度为22.78±8.605。采用单因素方差分析(One Way ANOVA)，发现全球哮喘患病率与印度哮喘患病率之间存在显著差异(t=48.44, df=4)，即平均差异为259.7±11.99。德里和拉贾斯坦邦的平均值最高，分别为19.74±11.79和13.58±9.47，昌迪加尔和北方邦的平均值分别为11.87±7.83和4.32±2.32。喜马偕尔邦和哈里亚纳邦的哮喘指数几乎相等，分别为1.67±0.13和1.23±0.33。
{"title":"An Overview of Integrated Risk Factors with Prevention and Prevalence of Asthma at the Global Level","authors":"R. Garg, Mona Piplani, Yogendra Pratap Singh, Pankaj Bhateja, R. Rana","doi":"10.2174/2215083810666230525153908","DOIUrl":"https://doi.org/10.2174/2215083810666230525153908","url":null,"abstract":"\u0000\u0000Bronchial asthma is one of the most common chronic illnesses in childhood, adulthood and pregnancy with a current occurrence of 6-9 percent, but at an alarming rate of increase. Asthma is a complex genetic disorder that is heavily affected by the environment. In association with significant morbidity, quality of life, and healthcare costs, it is putting an increasing strain on our society. Some factors related to pregnancy, i.e., diet-related, antibiotic uses, and stress; childhood risk factors, i.e., lung function, exposure to smoking, animal etc. and adulthood risk factor, i.e., pollution-related etc., are responsible for trends in incidence and mortality due to asthma at a Global level and Indian population. Data were collected from PubMed, Web of Sciences, CINHAL, WHO Clinical trial register, Google Scholar, and official websites of various asthma societies and statistically analyzed using ANOVA tests. Data were analyzed for India and the specific population of the northern region of India during the last five years. Risk factors related to asthma at different stages, i.e., genetic, pregnancy, childhood, and adulthood, were reviewed, and the prevalence of asthma at the Global level, India and northern India, was analyzed and compared. The mean Global prevalence of asthma was found to be 281.3±14.7 (SD), whereas, for India, it was 22.78±8.605. After applying One Way ANOVA, a significant difference (t=48.44, df=4) was found between the Global and Indian prevalence of asthma, i.e., the mean difference of 259.7±11.99. The mean value was found highest in Delhi and Rajasthan, having values of 19.74±11.79 and 13.58±9.47, whereas Chandigarh and Uttar Pradesh recorded asthma’s prevalence as 11.87±7.83 and 4.32±2.32 respectively. Himachal and Haryana acquired almost equal values of asthma at 1.67±0.13 and 1.23±0.33.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47562768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-23DOI: 10.2174/2215083810666230523155650
D. Patel, K. Patel
Daphnane-type diterpenes are an important class of phytochemicals found to be present in the family Euphorbiaceae and Thymelaeaceae. It has anti-leukaemic, anti-hyperglycaemic, and anti-fertility activities in medicine. Daphne genkwa is indigenous to the Yangtze River and Yellow River of China. Daphne genkwa contains significant amounts of daphnane-type diterpenes. Phytochemical analysis of Daphne genkwa led to the isolation of flavonoids, lignins, coumarins, caffeotannic acids, and genkwadaphnin. Present review highlighted the biological potential of genkwadaphnin in medicine. All the scientific data of Daphne genkwa, and genkwadaphnin were collected from Google, Google Scholar, Science Direct, Scopus, and PubMed and analyzed in the present work to know the therapeutic potential of genkwadaphnin in medicine. Detailed pharmacological activities of genkwadaphnin were analyzed in the present work through scientific data analysis of various research works. Genkwadaphnin is a daphnane diterpene ester molecule mainly isolated from the Daphne genkwa, Dendrostellera lessertii, Daphne odorata, Gnidia latifolia, and Gnidia glaucus. Genkwadaphnin has been reported to exert therapeutic potential against hepatocellular carcinoma, human colon cancer, squamous cell carcinoma, and leukemia. Further, it has a significant role in innate immunity, melanogenesis, skeletal diseases, inflammatory cytokines, and natural killer cell. However, pharmacokinetics and metabolomics aspects of genkwadaphnin were also discussed in the present work. Further, more scientific data on human clinical trials is needed to ensure the safety and efficacy of genkwadaphnin in medicine. In the present work, a successful review had been achieved by the above-mentioned scientific data, which signified the therapeutic potential of genkwadaphnin in medicine.
{"title":"Herbal Medicines Genkwadaphnin as Therapeutic Agent for Cancers and Other Human Disorders: A Review of Pharmacological Activities through Scientific Evidence","authors":"D. Patel, K. Patel","doi":"10.2174/2215083810666230523155650","DOIUrl":"https://doi.org/10.2174/2215083810666230523155650","url":null,"abstract":"\u0000\u0000Daphnane-type diterpenes are an important class of phytochemicals found to be present in the family Euphorbiaceae and Thymelaeaceae. It has anti-leukaemic, anti-hyperglycaemic, and anti-fertility activities in medicine. Daphne genkwa is indigenous to the Yangtze River and Yellow River of China. Daphne genkwa contains significant amounts of daphnane-type diterpenes. Phytochemical analysis of Daphne genkwa led to the isolation of flavonoids, lignins, coumarins, caffeotannic acids, and genkwadaphnin.\u0000\u0000\u0000\u0000Present review highlighted the biological potential of genkwadaphnin in medicine. All the scientific data of Daphne genkwa, and genkwadaphnin were collected from Google, Google Scholar, Science Direct, Scopus, and PubMed and analyzed in the present work to know the therapeutic potential of genkwadaphnin in medicine. Detailed pharmacological activities of genkwadaphnin were analyzed in the present work through scientific data analysis of various research works.\u0000\u0000\u0000\u0000Genkwadaphnin is a daphnane diterpene ester molecule mainly isolated from the Daphne genkwa, Dendrostellera lessertii, Daphne odorata, Gnidia latifolia, and Gnidia glaucus. Genkwadaphnin has been reported to exert therapeutic potential against hepatocellular carcinoma, human colon cancer, squamous cell carcinoma, and leukemia. Further, it has a significant role in innate immunity, melanogenesis, skeletal diseases, inflammatory cytokines, and natural killer cell. However, pharmacokinetics and metabolomics aspects of genkwadaphnin were also discussed in the present work. Further, more scientific data on human clinical trials is needed to ensure the safety and efficacy of genkwadaphnin in medicine.\u0000\u0000\u0000\u0000In the present work, a successful review had been achieved by the above-mentioned scientific data, which signified the therapeutic potential of genkwadaphnin in medicine.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46903563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-23DOI: 10.2174/2215083810666230523145738
M. Bora, S. Mandal, P. Singh, Himangi Das, Girindra Kumar Bora, D. Bora, D. Baruah, M. Gautam
Desmodium gangeticum (L.) DC., commonly known as Shalparni in Ayurveda, has been used for treating various diseases. The plant is one among ten ingredients of classical Ayurvedic formulations Dasamula. Decoctions of root and leaf, root powder and leaf juice of D. gangeticum are used as tonics, febrifuge, digestive, antiemetic, astringent, anti-asthmatic, anti-diarrhoeal and anti-inflammatory agents in traditional medicinal practices of India and its neighbouring countries. Phytochemical investigations of this plant revealed the presence of many bioactive phytoconstituents. The present review was prepared with the objective of documenting the phytochemical and pharmacological profiles of D. gangeticum. The data presented here were collected from various sources like books, journals, various online databases, and monographs and internet search engines Google Scholar, PubMed, Science Direct, etc. Studies reported from phytochemical screening revealed that D. Gangeticum leaves and roots are rich in flavonoids, alkaloids, terpenoids, tannins, phenols, carbohydrates, steroids, phenylpropanoids, pterocarpans, coumarins, and volatile oil. Among the isolated compounds, major bio-active constituents are alkaloids, flavonoids and pterocarpans. All these phytochemicals are widely distributed in various parts of D. gangeticum. The other active constituents like desmodin, hordenine and gangetin are largely responsible for its broad spectrum of therapeutic potentiality. Desmodin belongs to the class of pterocarpans and is reported to have antifungal and antibacterial activities. Gangetin, which also belongs to the pterocarpans, is reported to have anti-inflammatory and analgesic effects. FTIR spectroscopy showed that D. gangeticum extracts are mainly rich in phenolic derivatives. Scientific experiments carried out in vitro as well as preclinical animal experimentations, showed that the plant and its bioactive chemicals exhibit various therapeutic activities. It is reported that D. gangeticum extracts showed potent antioxidant, antibacterial, hypoglycaemic, analgesic, hepatoprotective, anti-inflammatory and antiarthritic activities. Studies reported that D. gangeticum or its formulations are safe when used in appropriate therapeutic dosage.
{"title":"Phytochemical and Pharmacological Profile of Desmodium gangeticum (L.) DC.: A Comprehensive Review","authors":"M. Bora, S. Mandal, P. Singh, Himangi Das, Girindra Kumar Bora, D. Bora, D. Baruah, M. Gautam","doi":"10.2174/2215083810666230523145738","DOIUrl":"https://doi.org/10.2174/2215083810666230523145738","url":null,"abstract":"\u0000\u0000Desmodium gangeticum (L.) DC., commonly known as Shalparni in Ayurveda, has been\u0000used for treating various diseases. The plant is one among ten ingredients of classical Ayurvedic\u0000formulations Dasamula. Decoctions of root and leaf, root powder and leaf juice of D. gangeticum\u0000are used as tonics, febrifuge, digestive, antiemetic, astringent, anti-asthmatic, anti-diarrhoeal and anti-inflammatory agents in traditional medicinal practices of India and its neighbouring countries.\u0000Phytochemical investigations of this plant revealed the presence of many bioactive phytoconstituents. The present review was prepared with the objective of documenting the phytochemical and\u0000pharmacological profiles of D. gangeticum. The data presented here were collected from various\u0000sources like books, journals, various online databases, and monographs and internet search engines\u0000Google Scholar, PubMed, Science Direct, etc. Studies reported from phytochemical screening revealed that D. Gangeticum leaves and roots are rich in flavonoids, alkaloids, terpenoids, tannins,\u0000phenols, carbohydrates, steroids, phenylpropanoids, pterocarpans, coumarins, and volatile oil.\u0000Among the isolated compounds, major bio-active constituents are alkaloids, flavonoids and pterocarpans. All these phytochemicals are widely distributed in various parts of D. gangeticum. The\u0000other active constituents like desmodin, hordenine and gangetin are largely responsible for its broad\u0000spectrum of therapeutic potentiality. Desmodin belongs to the class of pterocarpans and is reported\u0000to have antifungal and antibacterial activities. Gangetin, which also belongs to the pterocarpans, is\u0000reported to have anti-inflammatory and analgesic effects. FTIR spectroscopy showed that D. gangeticum extracts are mainly rich in phenolic derivatives. Scientific experiments carried out in vitro\u0000as well as preclinical animal experimentations, showed that the plant and its bioactive chemicals\u0000exhibit various therapeutic activities. It is reported that D. gangeticum extracts showed potent antioxidant, antibacterial, hypoglycaemic, analgesic, hepatoprotective, anti-inflammatory and antiarthritic activities. Studies reported that D. gangeticum or its formulations are safe when used in appropriate therapeutic dosage.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42150794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-22DOI: 10.2174/2215083810666230522100620
R. Adhikari, Prasamsha Panta, Asmita Khanal, S. Shrestha
Oil-yielding non-timber forest products (NTFPs), such as Diploknema butyracea (Roxb.) H. J. Lam, Saipindus mukurossi Gaertn, and Hippophae salicifolia L. are widely distributed throughout Nepal and have traditionally been used as medicines by the locals since ancient times. Extensive scientific studies have demonstrated a wide range of benefits of these plants, which can have multiple uses in the pharmaceutical, cosmeceutical, and food industries. The potential of the plants, however, has not been fully explored, and they are, thus, minimally used only by locals. These plants have the potential for the development of several value-added products, leading to commercialization. This paper aims to explore in detail the health benefits and economic values of these plants to review the entrepreneurial aspects, improved farming and processing, and value addition in the product.
产油非用材林产品，如丁酸松(Roxb.)H. J. Lam, Saipindus mukurossi Gaertn和Hippophae salicifolia L.广泛分布在尼泊尔各地，自古以来就被当地人作为传统药物使用。广泛的科学研究已经证明了这些植物的广泛益处，它们可以在制药、药妆和食品工业中有多种用途。然而，这些植物的潜力还没有得到充分的开发，因此，只有当地人很少使用它们。这些工厂具有开发几种增值产品的潜力，从而实现商业化。本文旨在详细探讨这些植物的健康效益和经济价值，以回顾其创业方面，改进耕作和加工，以及产品的附加值。
{"title":"Oil-yielding Non-timber Plants Seeds: A Review on Their Application for Health Care Products","authors":"R. Adhikari, Prasamsha Panta, Asmita Khanal, S. Shrestha","doi":"10.2174/2215083810666230522100620","DOIUrl":"https://doi.org/10.2174/2215083810666230522100620","url":null,"abstract":"\u0000\u0000Oil-yielding non-timber forest products (NTFPs), such as Diploknema butyracea (Roxb.) H. J. Lam, Saipindus mukurossi Gaertn, and Hippophae salicifolia L. are widely distributed throughout Nepal and have traditionally been used as medicines by the locals since ancient times. Extensive scientific studies have demonstrated a wide range of benefits of these plants, which can have multiple uses in the pharmaceutical, cosmeceutical, and food industries. The potential of the plants, however, has not been fully explored, and they are, thus, minimally used only by locals. These plants have the potential for the development of several value-added products, leading to commercialization. This paper aims to explore in detail the health benefits and economic values of these plants to review the entrepreneurial aspects, improved farming and processing, and value addition in the product.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43999719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-19DOI: 10.2174/2215083810666230519115233
F. Erim, Sabire Cansu Aydın, Zeynep Kalaycıoğlu
Berberine is an alkaloid found in some medicinal plants. Berberine-containing plants have traditionally been used in the treatment of diseases since ancient times. Berberine is a natural compound that has an important place in traditional Chinese medicine. Currently, berberine is being evaluated extensively in clinical trials and is one of the natural products on which most scientific research studies have been published. Numerous clinical and pharmacological research results have been published on the therapeutic effect of berberine against cancer, diabetes, and heart disease The first purpose of this review is to display the berberine content of plants found in different regions of the world, and the second purpose is to provide the amount of berberine passing into the serum. Herbal supplements and extracts prepared from plants containing berberine are commercially marketed. The content of berberine in plants varies widely, and berberine is a quality indicator for many medicinal plants. Different analytical methods have been developed for reliable berberine analysis. Plant and serum berberine levels reported between the years 2013 and 2022 in journals covered by SCI are collected in this review article. We hope that this overview of berberine amounts will be useful in future pharmaceutical and pharmacokinetic studies.
{"title":"Berberine contents as a quality marker in medicinal plants and amounts of berberine passing into serum","authors":"F. Erim, Sabire Cansu Aydın, Zeynep Kalaycıoğlu","doi":"10.2174/2215083810666230519115233","DOIUrl":"https://doi.org/10.2174/2215083810666230519115233","url":null,"abstract":"\u0000\u0000Berberine is an alkaloid found in some medicinal plants. Berberine-containing plants have traditionally been used in the treatment of diseases since ancient times. Berberine is a natural compound that has an important place in traditional Chinese medicine. Currently, berberine is being evaluated extensively in clinical trials and is one of the natural products on which most scientific research studies have been published. Numerous clinical and pharmacological research results have been published on the therapeutic effect of berberine against cancer, diabetes, and heart disease\u0000\u0000\u0000\u0000The first purpose of this review is to display the berberine content of plants found in different regions of the world, and the second purpose is to provide the amount of berberine passing into the serum.\u0000\u0000\u0000\u0000Herbal supplements and extracts prepared from plants containing berberine are commercially marketed. The content of berberine in plants varies widely, and berberine is a quality indicator for many medicinal plants.\u0000\u0000\u0000\u0000Different analytical methods have been developed for reliable berberine analysis. Plant and serum berberine levels reported between the years 2013 and 2022 in journals covered by SCI are collected in this review article.\u0000\u0000\u0000\u0000We hope that this overview of berberine amounts will be useful in future pharmaceutical and pharmacokinetic studies.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47989545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-16DOI: 10.2174/2215083810666230516113258
V. Gupta, Gunpreet Kaur, Ravinder Sharma, P. Bansal
According to the WHO, the Centers for Disease Control and Prevention (CDC), and the US Food and Drug Administration (FDA), no medications/vaccines are proven to be fully effective for the treatment/prevention of SARS-CoV-2. All are aware that the virus is acting through the respiratory system due to lowered immunity of the body and have a devastating effect on the mental health of populations worldwide. There are very remote chances of developing a drug in a short span of time, along with tested safety and efficacy. Hence there is a need to find out some home remedies accessible to all. Here authors propose a food supplement Chaywanprash (ChyPra), which has been used by populations worldwidfor ages without any established side effects. It also contains quinine in minute quantities and a number of proven antiviral active components for SARS CoV. In addition, this formula is recommended in Ayurveda for the maintenance of mental health and rejuvenation.
{"title":"Populations using Traditional Home Remedy at Low Risk for Covid-19 Infection","authors":"V. Gupta, Gunpreet Kaur, Ravinder Sharma, P. Bansal","doi":"10.2174/2215083810666230516113258","DOIUrl":"https://doi.org/10.2174/2215083810666230516113258","url":null,"abstract":"\u0000\u0000According to the WHO, the Centers for Disease Control and Prevention (CDC), and the US Food and Drug Administration (FDA), no medications/vaccines are proven to be fully effective for the treatment/prevention of SARS-CoV-2. All are aware that the virus is acting through the respiratory system due to lowered immunity of the body and have a devastating effect on the mental health of populations worldwide. There are very remote chances of developing a drug in a short span of time, along with tested safety and efficacy. Hence there is a need to find out some home remedies accessible to all. Here authors propose a food supplement Chaywanprash (ChyPra), which has been used by populations worldwidfor ages without any established side effects. It also contains quinine in minute quantities and a number of proven antiviral active components for SARS CoV. In addition, this formula is recommended in Ayurveda for the maintenance of mental health and rejuvenation.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46747502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-15DOI: 10.2174/2215083810666230515161319
Y. Tabaza, T. Aburjai
As many Jordanians include herbs in their treatment, an ethnopharmacological survey was conducted to identify the most prescribed plants for the treatment of cancer by local herbalists and traditional healers in Jordan, aiming to encourage the prescription that is based on scientific evidence, to tackle some important practices in traditional healing, and to provide candidates for the isolation of new anticancer agents. Thirty-two Jordanian herbalists and traditional healers were interviewed. Both the use value and frequency of citation were implemented as quantitative methods to demonstrate the relative importance of a chosen species for the treatment of cancer. Furthermore, literature was screened for evidences that supported or opposed the use of the plants of interest It was revealed that 31 plants are currently used in Jordan for the treatment of cancer, with Curcuma longa and Ephedra foeminea being the most used ones. It was noticed that the use of many prescribed plants could be rationalised by in vitro and/or in vivo studies. However, more attention should be paid by practitioners to some important aspects, such as the method of use and preparation of plants, their interaction with chemotherapeutic agents and the differences in their efficacy against different cancer types.
{"title":"Ethnopharmacological Survey of Medicinal Plants \u0000Used by Local Herbalists and Traditional Healers for the Treatment of Cancer in Jordan","authors":"Y. Tabaza, T. Aburjai","doi":"10.2174/2215083810666230515161319","DOIUrl":"https://doi.org/10.2174/2215083810666230515161319","url":null,"abstract":"\u0000\u0000As many Jordanians include herbs in their treatment, an ethnopharmacological survey was conducted to identify the most prescribed plants for the treatment of cancer by local herbalists and traditional healers in Jordan, aiming to encourage the prescription that is based on scientific evidence, to tackle some important practices in traditional healing, and to provide candidates for the isolation of new anticancer agents.\u0000\u0000\u0000\u0000Thirty-two Jordanian herbalists and traditional healers were interviewed. Both the use value and frequency of citation were implemented as quantitative methods to demonstrate the relative importance of a chosen species for the treatment of cancer. Furthermore, literature was screened for evidences that supported or opposed the use of the plants of interest\u0000\u0000\u0000\u0000It was revealed that 31 plants are currently used in Jordan for the treatment of cancer, with Curcuma longa and Ephedra foeminea being the most used ones.\u0000\u0000\u0000\u0000It was noticed that the use of many prescribed plants could be rationalised by in vitro and/or in vivo studies. However, more attention should be paid by practitioners to some important aspects, such as the method of use and preparation of plants, their interaction with chemotherapeutic agents and the differences in their efficacy against different cancer types.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48866614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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