Pub Date : 2023-06-26DOI: 10.2174/2215083810666230626115456
R. Sharma, Nisha Singh, A. Kushwah, Manish Kumar
Chronic fatigue syndrome (CFS) is a complex condition marked by severe exhaustion that lasts at least 6 months. The global prevalence of CFS ranging between 0.4% and 2.5% is growing. Women are affected by CFS more often than men. It is considered a common condition in developed countries. There is no approved treatment for CFS but symptoms can be managed and controlled persistent exhaustion causes significant impairment in daily routine activities. Lowered ATP synthesis, mitochondrial impairment, decreased oxidative phosphorylation, disruption of the hypothalamic–pituitary–adrenal (HPA) axis, and an imbalance of brain neurotransmitters play a major role in the pathophysiology of CFS. The purpose of the present study is to figure out the several plants that are used as a source of medication in chronic fatigue syndrome (CFS) and its current therapeutic approach. The Indian medicinal herbs described in this article are very efficacious in the management of chronic fatigue syndrome symptoms due to the presence of phytochemicals. This review article also covers the current therapeutic approach for chronic fatigue syndrome in a concise form that comprises CBT (Cognitive based therapy), GET (Graded exercise therapy), usage of immunoglobins, psychodynamic counseling, and yoga therapy that includes isometric yoga and yoga nidra are very beneficial in alleviating the symptoms of chronic fatigue syndrome. Antidepressants, immunomodulatory agents, and corticosteroids come under conventional medication for CFS. This article explores different Indian medicinal herbs, their pharmacological properties, and their potential role and current treatments for reducing the severity of symptoms of chronic fatigue syndrome.
{"title":"Therapeutic Potential of Indian Medicinal Herbs and Current Therapeutic Approach Used to Mitigate the Symptoms of Chronic Fatigue Syndrome: A Review","authors":"R. Sharma, Nisha Singh, A. Kushwah, Manish Kumar","doi":"10.2174/2215083810666230626115456","DOIUrl":"https://doi.org/10.2174/2215083810666230626115456","url":null,"abstract":"\u0000\u0000Chronic fatigue syndrome (CFS) is a complex condition marked by severe exhaustion that lasts at least 6 months. The global prevalence of CFS ranging between 0.4% and 2.5% is growing. Women are affected by CFS more often than men. It is considered a common condition in developed countries. There is no approved treatment for CFS but symptoms can be managed and controlled persistent exhaustion causes significant impairment in daily routine activities. Lowered ATP synthesis, mitochondrial impairment, decreased oxidative phosphorylation, disruption of the hypothalamic–pituitary–adrenal (HPA) axis, and an imbalance of brain neurotransmitters play a major role in the pathophysiology of CFS. The purpose of the present study is to figure out the several plants that are used as a source of medication in chronic fatigue syndrome (CFS) and its current therapeutic approach. The Indian medicinal herbs described in this article are very efficacious in the management of chronic fatigue syndrome symptoms due to the presence of phytochemicals. This review article also covers the current therapeutic approach for chronic fatigue syndrome in a concise form that comprises CBT (Cognitive based therapy), GET (Graded exercise therapy), usage of immunoglobins, psychodynamic counseling, and yoga therapy that includes isometric yoga and yoga nidra are very beneficial in alleviating the symptoms of chronic fatigue syndrome. Antidepressants, immunomodulatory agents, and corticosteroids come under conventional medication for CFS. This article explores different Indian medicinal herbs, their pharmacological properties, and their potential role and current treatments for reducing the severity of symptoms of chronic fatigue syndrome.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68187760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-23DOI: 10.2174/2215083810666230623160622
Sonia Singh, Nikhil Gupta
Dementia is a brain disorder with progressive neurological disease. It destroys essential brain cells, impairing memory, thinking, and behavior in a severe way to impact health, enduring interests, and social life. Memory, cognition, orientation, learning capacity, language, and judgments gradually get impaired. Dementia results from anatomical and functional abnormalities, cerebral ischemia, energy deficits, calcium excess, glutamate-mediated excitotoxicity, and oxidative stress. Vascular dementia (VaD), which accounts for 10-15% of dementia cases, is the second most frequent form of dementia after Alzheimer's disease (AD). There are currently no approved pharmaceutical treatments for VaD, and traditional anti-AD therapies only offer modest, temporary relief from the symptoms of VaD. Since herbal remedies have a multicomponent and multitarget approach, they may provide effective treatments for VaD. Herbal remedies have been used for centuries to address dementia-like symptoms. This author describes some preliminary research that supports using herbal drugs in managing vascular dementia and dementia.
{"title":"Therapeutic Approach of Phytomedicine for Dementia: A Review","authors":"Sonia Singh, Nikhil Gupta","doi":"10.2174/2215083810666230623160622","DOIUrl":"https://doi.org/10.2174/2215083810666230623160622","url":null,"abstract":"\u0000\u0000Dementia is a brain disorder with progressive neurological disease. It destroys essential brain cells, impairing memory, thinking, and behavior in a severe way to impact health, enduring interests, and social life. Memory, cognition, orientation, learning capacity, language, and judgments gradually get impaired. Dementia results from anatomical and functional abnormalities, cerebral ischemia, energy deficits, calcium excess, glutamate-mediated excitotoxicity, and oxidative stress. Vascular dementia (VaD), which accounts for 10-15% of dementia cases, is the second most frequent form of dementia after Alzheimer's disease (AD). There are currently no approved pharmaceutical treatments for VaD, and traditional anti-AD therapies only offer modest, temporary relief from the symptoms of VaD. Since herbal remedies have a multicomponent and multitarget approach, they may provide effective treatments for VaD. Herbal remedies have been used for centuries to address dementia-like symptoms. This author describes some preliminary research that supports using herbal drugs in managing vascular dementia and dementia.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44803441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-22DOI: 10.2174/2215083810666230622111859
Jasmine Chaudhary, M. Bhatia, Akash Jain, Sonam, A. Dhingra, B. Chopra
Asthma is a chronic heterogeneous airway obstruction disorder defined by a complex cascade of pathophysiological conditions that lead to recurring bronchial hyper-responsiveness and underlying inflammation, lowering the patient’s quality of life. Despite the availability of various synthetic medications for the management of asthma, it has become one of the leading causes of death worldwide. Furthermore, the present allopathic treatment possesses severe long-term negative effects, which make people more attracted to the safer and easily available indigenous traditional and Ayurvedic system of medicine. Ayurveda is regarded as the “Mother of all healing” and “Science of Life,” which treats all the ailments, including asthma, by restoring a balance between three main components of the body- Vata, Pitta, and Dosha. Various clinically effective and less toxic anti-asthmatic Ayurvedic herbal preparations are available for the management of asthma and related complications which act by causing mast cell deactivation, inhibition of Th1, Th2, Th7 response, T-cell suppression, etc., therefore, efforts have been made to compile all the relevant literature related to the ayurvedic anti-asthmatic formulations and scrutinize the efficacy of selected plants present in the majority in those formulations in asthma along with the structure and mode of action of phytoconstituent responsible for designing novel molecules with better efficacy. Research on these selected plants can also have economic significance as various constituents isolated from these plants for their anti-asthmatic effect can further be explored to discover their potential in medicinal, diagnostic and cosmetic field.
{"title":"A recent update on Ayurvedic anti-asthmatic formulations: Highlighting the role of major anti-asthmatic plants","authors":"Jasmine Chaudhary, M. Bhatia, Akash Jain, Sonam, A. Dhingra, B. Chopra","doi":"10.2174/2215083810666230622111859","DOIUrl":"https://doi.org/10.2174/2215083810666230622111859","url":null,"abstract":"\u0000\u0000Asthma is a chronic heterogeneous airway obstruction disorder defined by a complex cascade of pathophysiological conditions that lead to recurring bronchial hyper-responsiveness and underlying inflammation, lowering the patient’s quality of life. Despite the availability of various synthetic medications for the management of asthma, it has become one of the leading causes of death worldwide. Furthermore, the present allopathic treatment possesses severe long-term negative effects, which make people more attracted to the safer and easily available indigenous traditional and Ayurvedic system of medicine. Ayurveda is regarded as the “Mother of all healing” and “Science of Life,” which treats all the ailments, including asthma, by restoring a balance between three main components of the body- Vata, Pitta, and Dosha. Various clinically effective and less toxic anti-asthmatic Ayurvedic herbal preparations are available for the management of asthma and related complications which act by causing mast cell deactivation, inhibition of Th1, Th2, Th7 response, T-cell suppression, etc., therefore, efforts have been made to compile all the relevant literature related to the ayurvedic anti-asthmatic formulations and scrutinize the efficacy of selected plants present in the majority in those formulations in asthma along with the structure and mode of action of phytoconstituent responsible for designing novel molecules with better efficacy. Research on these selected plants can also have economic significance as various constituents isolated from these plants for their anti-asthmatic effect can further be explored to discover their potential in medicinal, diagnostic and cosmetic field.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43560128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-13DOI: 10.2174/2215083810666230613091337
P. Wal, Namra Aziz, Anushka Verma, Sunil Kumar, H. B. Samal
In recent times, herbal medicines have experienced an expansion in both developing and developed countries due to their natural origin and low incidence of adverse effects. A systematic review was performed to gather information regarding herbal plants used to treat diabetes mellitus. The aim of this article was to review evidence from preclinical and clinical trials and the proposed mechanism of herbal drugs in diabetes mellitus. A literature survey was carried out mainly focused on scientific papers published in recent years. The search strategy involved interrelated keywords, like “Diabetes mellitus,” “Herbs,” “Hyperglycaemia,” and other uniterms. Electronic databases used were Scopus, Web of Science, PubMed, and Elsevier. Twenty studies, including preclinical and clinical trials, were selected for evaluating the mechanism of the anti-hyperglycaemic effect of herbal drugs in diabetes mellitus. Through clinical and preclinical research as well as an analysis of the mechanism of action of herbs, the current review provides preliminary evidence for possible anti-diabetic benefits of herbal medicines.
近年来，由于草药的天然来源和不良反应的低发生率，草药在发展中国家和发达国家都经历了扩张。进行了一项系统综述，以收集有关用于治疗糖尿病的草药植物的信息。本文的目的是回顾临床前和临床试验的证据，以及草药治疗糖尿病的机制。对近年来发表的科学论文进行了文献调查。搜索策略包括相互关联的关键词，如“糖尿病”、“草药”、“高血糖症”和其他单位词。使用的电子数据库包括Scopus、Web of Science、PubMed和Elsevier。选择了20项研究，包括临床前和临床试验，来评估草药对糖尿病抗高血糖作用的机制。通过临床和临床前研究以及对草药作用机制的分析，本综述为草药可能具有的抗糖尿病作用提供了初步证据。
{"title":"Herbs for the Therapy of Diabetes Mellitus: A Thorough Analysis with Particular Emphasis on Preclinical, Clinical Trials, and their Hypothesised Mechanisms","authors":"P. Wal, Namra Aziz, Anushka Verma, Sunil Kumar, H. B. Samal","doi":"10.2174/2215083810666230613091337","DOIUrl":"https://doi.org/10.2174/2215083810666230613091337","url":null,"abstract":"\u0000\u0000In recent times, herbal medicines have experienced an expansion in both developing and developed countries due to their natural origin and low incidence of adverse effects. A systematic review was performed to gather information regarding herbal plants used to treat diabetes mellitus.\u0000\u0000\u0000\u0000The aim of this article was to review evidence from preclinical and clinical trials and the proposed mechanism of herbal drugs in diabetes mellitus.\u0000\u0000\u0000\u0000A literature survey was carried out mainly focused on scientific papers published in recent years. The search strategy involved interrelated keywords, like “Diabetes mellitus,” “Herbs,” “Hyperglycaemia,” and other uniterms. Electronic databases used were Scopus, Web of Science, PubMed, and Elsevier.\u0000\u0000\u0000\u0000Twenty studies, including preclinical and clinical trials, were selected for evaluating the mechanism of the anti-hyperglycaemic effect of herbal drugs in diabetes mellitus.\u0000\u0000\u0000\u0000Through clinical and preclinical research as well as an analysis of the mechanism of action of herbs, the current review provides preliminary evidence for possible anti-diabetic benefits of herbal medicines.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47984882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-09DOI: 10.2174/2215083810666230609163404
Deepa S. Mandlik, R. Patil, S. Mandlik
Medicinal plants have significant therapeutic value and are a gift to humanity in pursuing healthy living. The discovery of numerous rejuvenating compounds that can stop or reduce the pathology of many diseases will be a crucial advancement in the coming years. Synthetic compounds can cause health issues and side effects, necessitating the development of molecules derived from plants and other natural resources as viable substitutes for synthetic compounds. Several plant phytochemicals and extracts have been found to have significant effects on traditional medical therapy. Murraya koenigii (M. Koenigii) is a member of the Rutaceae family, well-known in the Ayurvedic system of medicine as a therapeutically important herb of Indian origin. M. Koenigii has been used in several ancient systems of medicine, including Siddha and Unani, as a multi-potential medicinal plant. Previous research has shown that this plant's bark, roots, and leaves are abundant sources of carbazole alkaloids, which have beneficial pharmacological and biological effects. These include antioxidant, antibacterial, antidiabetic, anti-inflammatory, antihypertensive, antifungal, antiprotozoal, hepatoprotective, anti-hypercholesterolemic, antiulcer, cytotoxic, antidiarrheal, phagocytic, neuroprotective, and antitumor activities. The key components of the M. koenigii plant and their pharmacological activities against various diseases using preclinical models are discussed in this review. Exhaustive studies on the molecular mechanism of action of M. koenigii are needed to validate the effectiveness of curry tree and their constituents as potent therapeutic agents. However, serious efforts are required to identify, isolate and evaluate the chemical components for nutritional and medicinal potentials.
{"title":"Murraya koenigii (Curry tree): A review of its Phytochemistry, Ethnomedicinal uses, and Pharmacology with Respect to Molecular Mechanisms","authors":"Deepa S. Mandlik, R. Patil, S. Mandlik","doi":"10.2174/2215083810666230609163404","DOIUrl":"https://doi.org/10.2174/2215083810666230609163404","url":null,"abstract":"\u0000\u0000Medicinal plants have significant therapeutic value and are a gift to humanity in pursuing healthy living. The discovery of numerous rejuvenating compounds that can stop or reduce the pathology of many diseases will be a crucial advancement in the coming years. Synthetic compounds can cause health issues and side effects, necessitating the development of molecules derived from plants and other natural resources as viable substitutes for synthetic compounds. Several plant phytochemicals and extracts have been found to have significant effects on traditional medical therapy. Murraya koenigii (M. Koenigii) is a member of the Rutaceae family, well-known in the Ayurvedic system of medicine as a therapeutically important herb of Indian origin. M. Koenigii has been used in several ancient systems of medicine, including Siddha and Unani, as a multi-potential medicinal plant. Previous research has shown that this plant's bark, roots, and leaves are abundant sources of carbazole alkaloids, which have beneficial pharmacological and biological effects. These include antioxidant, antibacterial, antidiabetic, anti-inflammatory, antihypertensive, antifungal, antiprotozoal, hepatoprotective, anti-hypercholesterolemic, antiulcer, cytotoxic, antidiarrheal, phagocytic, neuroprotective, and antitumor activities. The key components of the M. koenigii plant and their pharmacological activities against various diseases using preclinical models are discussed in this review. Exhaustive studies on the molecular mechanism of action of M. koenigii are needed to validate the effectiveness of curry tree and their constituents as potent therapeutic agents. However, serious efforts are required to identify, isolate and evaluate the chemical components for nutritional and medicinal potentials.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43958653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-08DOI: 10.2174/2215083810666230608104601
D. Patel
{"title":"Biological importance and therapeutic potential of delicaflavone against cancerous disorders: A rare naturally occurring biflavonoids of Selaginella species","authors":"D. Patel","doi":"10.2174/2215083810666230608104601","DOIUrl":"https://doi.org/10.2174/2215083810666230608104601","url":null,"abstract":"<jats:sec>\u0000<jats:title />\u0000<jats:p />\u0000</jats:sec>","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46715833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-07DOI: 10.2174/2215083810666230607151656
N. Agrawal, Deepika Goyal, Dimple Bansal
Traditional Chinese medicine (TCM) is a complete medical system that has been used for more than 2,000 years and it is effective to use Epimedium Brevicornum (EB) Maxim, one of the Chinese herbs belonging to the family Berberidaceae is of major use because of its bioactive compound Icariin (ICA). This review aims on providing a collective report of the description, taxonomy, therapeutic uses, bioactive compounds, and the different pharmacological activities of the plant EB for future research. Data was obtained from various informative tools like PubMed, ScienceDirect, Google Scholar, and the botanical information sites for different plants. This literature review shows that the Chinese herb EB possesses various therapeutic effects and can be used in the prophylaxis of different ailments. The extract of different parts of EB contains many bioactive compounds such as phenols, flavonoids, and lignans. They show a wide range of pharmacological activities which include anti-inflammatory, anti-infertility, anti-cancer, and effective against Alzheimer’s disease and osteoporosis. ICA was found to be the major constituent of this herbal plant aiding in almost every pharmacological activity . The review covers every activity the plant holds and indicates that the plant is a useful source in eradicating a variety of ailments. Researchers have performed invitro and invivo experiments to explore plant capabilities. The plant could be of very much use in botanical and pharmacological fields. For experts aiming to research EB, this review could be a great source of information.
中国传统医学(Traditional Chinese medicine, TCM)是一个拥有2000多年历史的完整医学体系，其中以小檗科(Berberidaceae)中草药淫羊藿(Epimedium Brevicornum, EB)最为有效，因其具有生物活性化合物淫羊藿苷(Icariin, ICA)而被广泛使用。本文就植物EB的描述、分类、治疗用途、生物活性化合物及不同药理活性等方面进行综述，为今后的研究提供参考。数据来自各种信息工具，如PubMed、ScienceDirect、b谷歌Scholar和不同植物的植物信息网站。本文献综述表明，中药EB具有多种治疗作用，可用于预防不同的疾病。EB不同部位的提取物含有许多生物活性化合物，如酚类、类黄酮和木脂素。它们具有广泛的药理活性，包括抗炎、抗不孕、抗癌，并对阿尔茨海默病和骨质疏松症有效。ICA被发现是这种草药植物的主要成分，几乎有助于每一种药理活性。该综述涵盖了该植物所具有的每一种活性，并指出该植物是根除各种疾病的有用来源。研究人员已经进行了体外和体内实验来探索植物的能力。该植物在植物学和药理学领域具有广泛的应用价值。对于研究EB的专家来说，这篇综述可能是一个很好的信息来源。
{"title":"A Comprehensive Review on Chemistry and Contribution of Chinese Herb Epimedium brevicornum Maxim in Medicine","authors":"N. Agrawal, Deepika Goyal, Dimple Bansal","doi":"10.2174/2215083810666230607151656","DOIUrl":"https://doi.org/10.2174/2215083810666230607151656","url":null,"abstract":"\u0000\u0000Traditional Chinese medicine (TCM) is a complete medical system that has been used for more than 2,000 years and it is effective to use Epimedium Brevicornum (EB) Maxim, one of the Chinese herbs belonging to the family Berberidaceae is of major use because of its bioactive compound Icariin (ICA).\u0000\u0000\u0000\u0000This review aims on providing a collective report of the description, taxonomy, therapeutic uses, bioactive compounds, and the different pharmacological activities of the plant EB for future research.\u0000\u0000\u0000\u0000Data was obtained from various informative tools like PubMed, ScienceDirect, Google Scholar, and the botanical information sites for different plants.\u0000\u0000\u0000\u0000This literature review shows that the Chinese herb EB possesses various therapeutic effects and can be used in the prophylaxis of different ailments. The extract of different parts of EB contains many bioactive compounds such as phenols, flavonoids, and lignans. They show a wide range of pharmacological activities which include anti-inflammatory, anti-infertility, anti-cancer, and effective against Alzheimer’s disease and osteoporosis. ICA was found to be the major constituent of this herbal plant aiding in almost every pharmacological activity\u0000.\u0000\u0000\u0000\u0000The review covers every activity the plant holds and indicates that the plant is a useful source in eradicating a variety of ailments. Researchers have performed invitro and invivo experiments to explore plant capabilities. The plant could be of very much use in botanical and pharmacological fields. For experts aiming to research EB, this review could be a great source of information.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42920121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-07DOI: 10.2174/2215083810666230607093151
Canzhong Lu, Yuchen Xiao, Jianping Yong
Natural products provide abundant resources for the development of new drugs. Podocarpus nagi is an arbor of Podocarpus L'Hér. ex Persoon. Its fruits, leaves, and roots exhibit a broad spectrum of pharmacological activities (such as antitumor, plant growth regulation, termite killing, and insect larval toxicity), which have been used in Yao folk for a long history. Nagilactone is one of the key components discovered in Podocarpus nagi, which has a variety of structures and a broad spectrum of antitumor activities. In this mini-review, the structures and spectral characteristics, together with the antitumor activities and the structure-activity relationships of nagilactones, are summarized by searching the database in order to provide detailed references for researchers to elucidate and modify their structures.
{"title":"A Mini-review on the Structural Characteristics and Anticancer \u0000Activity of Nagilactones","authors":"Canzhong Lu, Yuchen Xiao, Jianping Yong","doi":"10.2174/2215083810666230607093151","DOIUrl":"https://doi.org/10.2174/2215083810666230607093151","url":null,"abstract":"\u0000\u0000Natural products provide abundant resources for the development of new drugs. Podocarpus nagi is an arbor of Podocarpus L'Hér. ex Persoon. Its fruits, leaves, and roots exhibit a broad spectrum of pharmacological activities (such as antitumor, plant growth regulation, termite killing, and insect larval toxicity), which have been used in Yao folk for a long history. Nagilactone is one of the key components discovered in Podocarpus nagi, which has a variety of structures and a broad spectrum of antitumor activities. In this mini-review, the structures and spectral characteristics, together with the antitumor activities and the structure-activity relationships of nagilactones, are summarized by searching the database in order to provide detailed references for researchers to elucidate and modify their structures.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43069723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-02DOI: 10.2174/2215083810666230602152743
H. Babavalian, F. Shakeri, Hamideh Moghimi, M. Afsharian, Aida Alipashazadeh, Sahar Zuhuriyan Izadi
Ganoderma lucidum (Lingzhi), a common medicinal fungus, has been utilized in China since ancient times for health promotion and longevity. It has anti-inflammatory, antiviral, antitumor, antioxidant, and antiallergic activities. The antioxidant and immunomodulatory effects of this mushroom have shown promising impacts in the treatment of some viral diseases. COVID-19 is a life-threatening disease caused by SARS-CoV-2 that has recently been pandemic. Modern medicines have not been very efficient in the direct treatment of these viral infections, and although vaccination is effective in preventing viral infections, the incidence of acute respiratory infection can be reduced only slightly. Thus, alternative therapies are required, and in this regard, stimulating the immune system can be an effective way to prevent these infections. This study reports the potential of natural fungus-derived compounds that can possibly be used to fight SARS-CoV-2 infections.
{"title":"Anti-viral Application of Ganoderma Lucidum in COVID-19","authors":"H. Babavalian, F. Shakeri, Hamideh Moghimi, M. Afsharian, Aida Alipashazadeh, Sahar Zuhuriyan Izadi","doi":"10.2174/2215083810666230602152743","DOIUrl":"https://doi.org/10.2174/2215083810666230602152743","url":null,"abstract":"\u0000\u0000Ganoderma lucidum (Lingzhi), a common medicinal fungus, has been utilized in China since ancient times for health promotion and longevity. It has anti-inflammatory, antiviral, antitumor, antioxidant, and antiallergic activities. The antioxidant and immunomodulatory effects of this mushroom have shown promising impacts in the treatment of some viral diseases. COVID-19 is a life-threatening disease caused by SARS-CoV-2 that has recently been pandemic. Modern medicines have not been very efficient in the direct treatment of these viral infections, and although vaccination is effective in preventing viral infections, the incidence of acute respiratory infection can be reduced only slightly. Thus, alternative therapies are required, and in this regard, stimulating the immune system can be an effective way to prevent these infections. This study reports the potential of natural fungus-derived compounds that can possibly be used to fight SARS-CoV-2 infections.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42349519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-02DOI: 10.2174/2215083810666230602163727
M. Yousefi, M. Abazari, A. Gholoobi, A. Derakhshan, Shahin Saeedinejat
Cardiovascular diseases (CVD) are the leading cause of health problems worldwide. CVD are defined as conditions affecting the heart and blood vessels. Mortality due to cardiovascular diseases has increased in recent years. However, they can be easily controlled by reducing risk factors, including lipid profile, blood pressure, tobacco, alcohol, and low physical activity. Fruits have an important role in improving the risk factors of CVD. Ancient medical sources can play an important role in generating ideas for new research. In this study, the most common fruits that have been recommended by Persian traditional physicians in patients with CVD were reviewed. New documents supporting these effects were also extracted through a search on electronic databases. The findings showed that some fruits have a therapeutic role in CVD, according to Persian traditional medicine. Old Persian traditional physicians, such as Avicenna, advised fruits, including apples, lemon, pomegranate, pineapple, quince, cucumber, plums, and citron, for the treatment of CVDs. Several studies have been carried out on the effects of the above fruits, including apple (Malus pumila), pomegranate (Punica granatum), pineapple (Ananas comosus), Quince (Cydonia oblonga Mill.), fig (Ficus carica L.), and olive (Olea europaea). Modulation of signaling pathways and molecular properties that leads to reducing lipid metabolism disorders, correcting endothelial dysfunction, reducing blood pressure, reducing oxidative stress, and suppressing inflammation responses are the major mechanisms conducted by these fruits in preventing CVD. These pieces of evidence show that the opinion of Iranian medicine physicians regarding choosing fruits for treating CVD is worthy of consideration and an entry for deriving hypotheses for future studies.
{"title":"The Role of the Most Important Fruits in the Prevention and Treatment of Cardiovascular Diseases in Persian Traditional Medicine","authors":"M. Yousefi, M. Abazari, A. Gholoobi, A. Derakhshan, Shahin Saeedinejat","doi":"10.2174/2215083810666230602163727","DOIUrl":"https://doi.org/10.2174/2215083810666230602163727","url":null,"abstract":"\u0000\u0000Cardiovascular diseases (CVD) are the leading cause of health problems worldwide. CVD are defined as conditions affecting the heart and blood vessels. Mortality due to cardiovascular diseases has increased in recent years. However, they can be easily controlled by reducing risk factors, including lipid profile, blood pressure, tobacco, alcohol, and low physical activity. Fruits have an important role in improving the risk factors of CVD. Ancient medical sources can play an important role in generating ideas for new research. In this study, the most common fruits that have been recommended by Persian traditional physicians in patients with CVD were reviewed. New documents supporting these effects were also extracted through a search on electronic databases. The findings showed that some fruits have a therapeutic role in CVD, according to Persian traditional medicine. Old Persian traditional physicians, such as Avicenna, advised fruits, including apples, lemon, pomegranate, pineapple, quince, cucumber, plums, and citron, for the treatment of CVDs. Several studies have been carried out on the effects of the above fruits, including apple (Malus pumila), pomegranate (Punica granatum), pineapple (Ananas comosus), Quince (Cydonia oblonga Mill.), fig (Ficus carica L.), and olive (Olea europaea). Modulation of signaling pathways and molecular properties that leads to reducing lipid metabolism disorders, correcting endothelial dysfunction, reducing blood pressure, reducing oxidative stress, and suppressing inflammation responses are the major mechanisms conducted by these fruits in preventing CVD. These pieces of evidence show that the opinion of Iranian medicine physicians regarding choosing fruits for treating CVD is worthy of consideration and an entry for deriving hypotheses for future studies.\u0000","PeriodicalId":11026,"journal":{"name":"Current Traditional Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41463802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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