Dermatology Reports最新文献

Dermatitis herpetiformis (DH) is an uncommon autoimmune blistering skin disorder linked to gluten sensitivity. This report describes the line-field confocal optical coherence tomography (LC-OCT) features in a DH case, correlating with histopathological findings. A 60-year-old man exhibited erythematous papules and vesicles on the trunk with itching and burning, alongside alternating bowel issues. LC-OCT revealed subepidermal hypo-reflective areas with hyper-reflective floating cells at the dermal papillae tips. Histopathology showed subepidermal vesiculation and neutrophilic microabscesses, confirmed by granular IgA deposits in the dermal papillae via direct immunofluorescence. The patient tested positive for anti-tissue transglutaminase antibodies, was referred to a gastroenterologist, and began dapsone treatment, resolving the skin lesions. LC-OCT findings were consistent with histopathology, supporting its utility in diagnosing DH. Despite clinical similarities between DH and other blistering disorders, LC-OCT offers a non-invasive diagnostic approach, aiding in identifying optimal biopsy sites and expediting treatment. Further studies are warranted to validate LC-OCT's potential.

Dear Editor, A 50-year-old Caucasian male presented with a 30-year history of facial vitiligo, primarily affecting the chin and the perioral and periorbital regions. He had undergone multiple treatments over the years, including targeted phototherapy, topical corticosteroids, and calcineurin inhibitors, with limited success. [...].

The landscape of dermatology is undergoing a significant transformation as the field grapples with the implications of diversity, equity, and inclusion (DEI) initiatives. These efforts are pivotal in addressing and reducing disparities in patient outcomes, particularly for people of color (POC). This summary examines the disparities in dermatology, the importance of DEI initiatives, the impact of a recent Supreme Court decision, and the ongoing debates within the American Academy of Dermatology (AAD) regarding DEI policies. [...].

Psoriasis is a dermatological disorder whose clinical manifestations have attracted the interest of physicians since ancient times. Hippocrates of Cos in the 5th century B.C. and later Galen in the 1st century A.D. were the first to refer to skin lesions characterized by scales and itching. In the 19th century, dermatology progressed, gaining scientific autonomy and leading to improvements both in the clinical study of psoriasis and in the search for new treatment methodologies. The dermatological schools established in this century, located in London, Paris, and Vienna, dedicated themselves to studying skin diseases, adopting unique methodological approaches and creating dermatological nomenclature. The English school focused on the objective description of lesions, while the French school was the first to approach the study of evolutionary processes, formulating theories not always based on experimental methods. Finally, the Austrian school based its research entirely on the study of diseases through the use of instruments and laboratory tests. Representatives of all three schools played a crucial role in the scientific progress of dermatology, leading to the subsequent evolution and improvement of therapies, which gradually replaced the use of ancient remedies and archaic administration methods. The treatments promoted by the different 19th-century European dermatologists reflected both their scientific thinking and the medical beliefs of the time. For this reason, the following historical-medical reconstruction of the evolution of psoriasis therapies in the 19th century can contribute to enriching the studies of dermatology.

This study assessed the implementation of a tele-genetic counseling (TGC) pathway for hereditary melanoma risk using the culturally adapted Italian Melanoma Intergroup Tele-Genomics Outcome Scale (IMI-TGOS) questionnaire. Among 278 eligible patients, 177 (64%) completed the survey across three Italian centers. Responses showed high comprehension and perceived utility: 88% of participants reported understanding the information received, 96% recognized familial implications, and over 85% felt confident in managing risk and making decisions. While emotional responses were more varied, most respondents expressed confidence in future planning. These findings confirm the feasibility, acceptability, and informativeness of the IMI-TGOS in a remote counseling setting. The study supports the comparability of tele-genetic and in-person counseling in terms of understanding, retention, and decision-making. Moreover, the IMI-TGOS emerged as a promising tool for evaluating real-world genetic services. Broader adoption may help monitor outcomes and improve quality and equity in the expanding landscape of digital genetic care.

Melasma is a benign skin condition characterized by hyperpigmented patches, primarily affecting the face, and significantly reducing patients' quality of life. Treatment is challenging due to its recurrent nature, with no single modality proving universally effective. The combination of Q-switched Nd:YAG laser treatment and FOB® Tri-White Serum (Hong Nhung Cosmetics Co., Ltd., Can Tho, Vietnam) may represent a promising new therapeutic approach. This cross-sectional descriptive study involved 85 female patients with melasma treated at two dermatological centers between July 2023 and June 2024. Patients underwent four Q-switched Nd:YAG laser sessions (1064 nm, 1.5-1.7 J/cm2) at three-week intervals and applied FOB® Tri-White Serum twice or three times daily. Treatment effectiveness was assessed using the Melasma Area Severity Index (MASI) score and the Felix Von Luschan skin color chart. Data were analyzed using Stata 17.0 MP, with p<0.05 considered statistically significant. The mean MASI score improved significantly from 7.5±4.7 to 4.9±3.5 (p<0.05), with a 69.4% response rate. Younger patients (<45 years), individuals with a shorter disease duration (≤36 months), and cases of mild to moderate melasma exhibited more favorable outcomes. Adverse effects from both the laser and serum were mild and transient. The combination of Q-switched Nd:YAG laser and FOB® Tri-White Serum is a safe and effective treatment for melasma, demonstrating significant improvement in pigmentation with minimal side effects. Further research is needed to validate these findings with larger sample sizes and control groups.

Despite new EU regulations, allergies to red ink tattoos remain an urgent public health problem. Red tattoo pigments continue to occur at a clinically relevant rate. This observation raises critical questions about the effectiveness, scope, and enforcement of the Registration, Evaluation, Authorisation, and Restriction of Chemicals (REACH) regulation. We argue that current tattoo ink restrictions fail to sufficiently protect European consumers from known allergens and that regulatory revisions are urgently needed.

The sociological and psychological consequences of premature hair greying (PHG) are significant. PHG has been linked to various intrinsic and extrinsic factors, including genetic predispositions and environmental influences. The widespread use of hair growth-stimulating products may impact the hair greying process. This cross-sectional study aimed to determine the prevalence of hair greying among rosemary users in the Saudi Arabian population. A self-administered questionnaire was distributed among the sample population in the form of an online survey. This questionnaire included sociodemographic data (e.g., age, gender, and education), the use of several types of rosemary, and the outcomes. A total of 994 participants completed the survey, the majority of whom were female (94.4%). Participants aged between 18 and 24 years represented 64% of the sample. Hair loss was reported by 75.4% of respondents. More than half (58.7%) reported using rosemary, particularly rosemary oil, as a treatment. Among those who used rosemary, 22.8% reported experiencing hair greying. Increasing age emerged as an independent risk factor for PHG. However, multivariate regression analysis showed that the use of rosemary oil was associated with a reduced likelihood of hair greying. Approximately 25% of rosemary users developed PHG, and Individuals in the early to middle-age range with a bachelor's degree or higher had a 1.5 to 3.5 times greater risk of hair greying. Nevertheless, the use of rosemary oil appeared to mitigate this risk. Additional observational studies are needed to validate the high regional prevalence of hair greying, potentially associated with rosemary use.

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by painful nodules, abscesses, and draining tunnels in areas such as the axillae, groin, and inframammary regions. It typically emerges in early adulthood, with a global prevalence of approximately 1%, though regional variations exist. HS significantly affects patients' quality of life and imposes considerable socioeconomic burdens. It is frequently associated with metabolic syndrome, inflammatory arthritis, and inflammatory bowel disease, reflecting its underlying systemic inflammatory nature. The pathogenesis of HS involves innate immune mechanisms, including macrophages, neutrophils, interleukin (IL)-1β, tumor necrosis factor-alpha (TNF-α), and granulocyte colony-stimulating factor, alongside adaptive immune responses mediated by T cells (IL-17, interferon-gamma [IFN-γ]) and B cells, which contribute to autoantibody formation and tertiary lymphoid structures. Chronic inflammation results in irreversible tissue damage, tunnel formation, and severe scarring. Treatment strategies vary based on disease severity. Early inflammatory stages benefit from pharmacological therapies, while later stages require a combination of medical and surgical interventions, with surgery often necessary for advanced cases. The introduction of targeted biologic therapies, including TNF-α (adalimumab) and IL-17 inhibitors (secukinumab, bimekizumab), has expanded treatment options beyond traditional antibiotic regimens. Effective management focuses on early intervention to prevent irreversible damage, control symptoms such as pain, and address systemic comorbidities. A timely diagnosis, along with a multidisciplinary and personalized approach, is essential for improving patient outcomes and quality of life.

Nevus of Ota is a benign pigmentation disorder that commonly affects areas of the skin and eyes innervated by the ophthalmic and maxillary branches of the trigeminal nerve. It typically presents as blue-black or gray macules, mainly in individuals with darker skin tones, and can cause significant cosmetic concerns. Treatment options include cryotherapy, dermabrasion, and laser therapy, with the Q-switched (QS) Nd:YAG (1064 nm) laser emerging as a promising option. This report describes the case of a 25-year-old woman diagnosed with unilateral nevus of Ota. After clinical examination, the patient was treated with the QS Nd:YAG laser, undergoing 12 treatment sessions over three years. A significant reduction in pigmentation was observed with no adverse effects. This case demonstrates the effectiveness of the QS Nd:YAG laser in managing nevus of Ota and highlights the importance of appropriate laser settings, patient selection, and post-treatment care. Laser therapy, particularly with the QS Nd:YAG laser, may offer a reliable and durable solution for reducing pigmentation and improving the cosmetic appearance of patients with this condition.