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Global Fluoride Toxicology Landscape: Bibliometric Approaches and Scientific Mapping 全球氟化物毒理学景观:文献计量方法和科学制图
IF 4.5 3区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2025-11-17 DOI: 10.1002/tox.24600
Maria Karolina Martins Ferreira, Deiweson Souza‐Monteiro, Priscila Cunha Nascimento, Luciana Eiró‐Quirino, Leonardo Oliveira Bittencourt, Fatemeh Vida Zohoori, Esperanza Angeles Martinez‐Mier, Marilia Afonso Rabelo Buzalaf, Rafael Rodrigues Lima
This study analyzed research trends in the 100 most‐cited articles on fluoride toxicology, a topic widely debated due to the toxic effects associated with levels deemed safe for human exposure. A bibliometric analysis was conducted using the Web of Science‐Core Collection, extracting data such as citation count, authors, keywords, journal, publication year, country, and continent. After reviewing the studies, additional information—including study design, investigated organs and tissues, main outcomes, and fluoride levels—was obtained. The initial search retrieved 5983 articles, from which the 100 most‐cited were selected, totaling 16 813 citations. The journal Fluoride published the highest number of articles ( n = 9), with keywords like “fluoride,” “fluorosis,” “dental fluorosis,” and “oxidative stress” being the most prevalent. India and China accounted for the largest share of publications. The most common study types were observational studies, literature reviews, and in vitro studies. Several studies reported fluoride's effects on dental and skeletal fluorosis, as well as damage to the brain, thyroid, gastrointestinal tract, heart, liver, kidneys, and specific cell types. This study highlights significant concerns regarding excessive fluoride exposure and identifies key research trends and gaps, particularly in the understanding of molecular mechanisms underlying fluoride‐induced damage.
本研究分析了100篇被引用最多的氟化物毒理学文章的研究趋势,由于与人体暴露安全水平相关的毒性影响,氟化物毒理学是一个广泛争论的话题。使用Web of Science‐Core Collection进行文献计量学分析,提取引文计数、作者、关键词、期刊、出版年份、国家和大洲等数据。在回顾了这些研究之后,获得了更多的信息,包括研究设计、调查的器官和组织、主要结果和氟化物水平。最初的检索检索了5983篇文章,从中选出了被引用次数最多的100篇,共被引用16813次。《氟化物》杂志发表的文章数量最多(n = 9),其中“氟化物”、“氟中毒”、“氟牙症”和“氧化应激”等关键词最为普遍。印度和中国占据了出版物的最大份额。最常见的研究类型是观察性研究、文献综述和体外研究。几项研究报告了氟化物对牙齿和骨骼氟中毒的影响,以及对大脑、甲状腺、胃肠道、心脏、肝脏、肾脏和特定细胞类型的损害。本研究强调了对过量氟化物暴露的重大关注,并确定了关键的研究趋势和差距,特别是在理解氟化物诱导损伤的分子机制方面。
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引用次数: 0
EXPRESSION OF CONCERN: CircWHSC1 Serves as a Prognostic Biomarker and Promotes Malignant Progression of Non-Small-Cell Lung Cancer Via miR-590-5p/SOX5 Axis 关注的表达:CircWHSC1作为预后生物标志物,通过miR‐590‐5p/ SOX5轴促进非小细胞肺癌的恶性进展
IF 3.2 3区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2025-11-12 DOI: 10.1002/tox.70001

EXPRESSION OF CONCERN: B. Wu, X. Wang, R. Yu, and X. Xue, “ CircWHSC1 Serves as a Prognostic Biomarker and Promotes Malignant Progression of Non-Small-Cell Lung Cancer Via miR-590-5p/SOX5 Axis,” Environmental Toxicology 38, no. 10 (2023): 24402449, https://doi.org/10.1002/tox.23879.

This Expression of Concern is for the above article, published online on 7 July 2023 in Wiley Online Library (http://wileyonlinelibrary.com), and has been issued by agreement between the journal Editor-in-Chief, April Rodd; and Wiley Periodicals LLC. Following publication, concerns were raised regarding the animal experimental data and Figure 2. Discrepancies were noted because the figure shows data beyond the “4 weeks after implantation” described for euthanasia in the main text. Additionally, the authors did not respond to the publisher's request to provide the original data, the ethics approval codes, and proof of patient consent. In the absence of the original data, the journal and publisher are unable to fully investigate the discrepancies. Therefore, the journal has decided to issue an Expression of Concern to inform and alert readers.

关注表达:吴波,王晓霞,于瑞仁,薛晓霞,”,环境毒理学38,no. 1。(2023): 2440 - 2449, https://doi.org/10.1002/tox.23879。此关注表达是针对上述文章,该文章于2023年7月7日在线发表在Wiley在线图书馆(http://wileyonlinelibrary.com)上,并经期刊主编April Rodd;和Wiley期刊有限责任公司。发表后,人们对动物实验数据和图2提出了担忧。之所以注意到差异,是因为图中显示的数据超出了正文中描述的安乐死的“植入后4周”。此外,作者没有回应出版商提供原始数据、伦理批准代码和患者同意证明的要求。在没有原始数据的情况下,期刊和出版商无法全面调查这些差异。因此,该杂志决定发布一份关注表达,以通知和提醒读者。
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引用次数: 0
RETRACTION: Long Noncoding RNA CASC9 Promotes Pancreatic Cancer Progression by Acting as a ceRNA of miR-497-5p to Upregulate Expression of CCND1 摘要:长链非编码RNA CASC9通过作为miR‐497‐5p的ceRNA上调CCND1的表达来促进胰腺癌的进展
IF 3.2 3区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2025-11-12 DOI: 10.1002/tox.70000

RETRACTION: J. Zhou, G. Song, M. Su, H. Zhang, T. Yang, and Z. Song, “ Long Noncoding RNA CASC9 Promotes Pancreatic Cancer Progression by Acting as a ceRNA of miR-497-5p to Upregulate Expression of CCND1,” Environmental Toxicology 38, no. 6 (2023): 12511264, https://doi.org/10.1002/tox.23761.

The above article, published online on 22 March 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, April Rodd; and Wiley Periodicals LLC. Following publication, duplications were noted in Figures 6G; in multiple panels within Figures 6F and 5O; in multiple panels between Figures 2D and 5O; and between Figures 4J and 5O. Additionally, the western blots in Figure 6H were duplicated from an earlier publication by different authors (Tang et al., 2020 [https://doi.org/10.18632/aging.103833]); Figure 3B is duplicated from an earlier publication by different authors (Zhou et al., 2020 [https://doi.org/10.2147/CMAR.S276297]); and Figure 5E is duplicated from an earlier publication by different authors (Yang et al., 2019 [https://doi.org/10.1186/s11658-019-0192-7]). The retraction has been agreed to because of evidence that significant portions of multiple figures were duplicated, affecting the interpretation of the data and results presented.

The authors agree with the retraction.

引用本文:周建军,宋国光,苏明,张慧,杨涛,宋忠,",环境毒理学38,no。(2023): 1251 - 1264, https://doi.org/10.1002/tox.23761。上述文章于2023年3月22日在线发表在Wiley在线图书馆(http://onlinelibrary.wiley.com/)上,经期刊主编April Rodd;和Wiley期刊有限责任公司。出版后,图6G中注明了重复;在图6F和图50内的多个面板中;在图2D和图50之间的多个面板中;介于图4J和图50之间。此外,图6H中的western blots是由不同作者从早期发表的文章中复制的(Tang et al., 2020 [https://doi.org/10.18632/aging.103833]);图3B复制自不同作者的早期出版物(Zhou et al., 2020 [https://doi.org/10.2147/CMAR.S276297]);图5E复制自不同作者的早期出版物(Yang et al., 2019 [https://doi.org/10.1186/s11658‐019‐0192‐7])。由于有证据表明多个数字的重要部分被重复,影响了对所呈现的数据和结果的解释,因此同意撤回。作者同意撤稿。
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引用次数: 0
Profiles of Phthalic Acid Esters ( PAEs ) in Various Water Matrices and the Associated Ecological and Health Risk Assessments 邻苯二甲酸酯(PAEs)在不同水基质中的分布及相关的生态和健康风险评估
IF 4.5 3区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2025-11-11 DOI: 10.1002/tox.24580
Qian Wang, Li Huang, Wei Huang, Qingkun Yang, Ling Wu, Qiurong He, Zunzhen Zhang, Xiu Huang, Jing Zhang
Phthalic acid esters (PAEs) exhibit ubiquitous contamination across aquatic systems, yet their spatiotemporal dynamics and associated risks remain poorly characterized. To address this, this study measured the concentrations of 13 PAEs in river samples collected from various locations along the Jinjiang River in Chengdu at different times, as well as in tap water samples from five different floors of a building and bottled water from five brands. Additionally, ecological risks were assessed using SSD curves, and health risks were evaluated based on USEPA‐validated health risk models. The results indicated that surface water ΣPAEs ranged from 0.016 to 9.36 μg/L, with DBP (9.36 ± 2.46 μg/L) and DIBP (5.66 ± 1.49 μg/L) being the primary contributors, and significantly higher concentrations were observed upstream (most p < 0.05). Bottled and tap water ΣPAEs ranged from 0.015 to 7.42 and 0.019 to 7.79 μg/L, respectively, both dominated by DBP (bottled: 7.41 ± 0.35; tap: 7.79 ± 0.35 μg/L). Natural mineral bottled water showed the highest ΣPAEs, whereas ΣPAEs in tap water decreased with increasing building floor height. Furthermore, ecological risks to shellfish were identified, yet human health risks (oral/dermal) for adults/children remained low across all water types. Despite the high detection rates of PAEs, the dangers of population exposure were minimal. However, natural mineral bottled water and tap water from lower floors require prioritized monitoring due to higher PAE levels in surface water associated with human activities.
邻苯二甲酸酯(PAEs)在水生系统中表现出普遍的污染,但其时空动态和相关风险的特征仍然很差。为了解决这个问题,本研究测量了在成都晋江沿岸不同地点在不同时间采集的河流样本中13种PAEs的浓度,以及一栋建筑的五个不同楼层的自来水样本和五个品牌的瓶装水样本。此外,采用SSD曲线评估生态风险,基于USEPA验证的健康风险模型评估健康风险。结果表明:地表水ΣPAEs在0.016 ~ 9.36 μg/L范围内,DBP(9.36±2.46 μg/L)和DIBP(5.66±1.49 μg/L)是主要贡献源,上游浓度显著高于上游(p < 0.05);瓶装水和自来水ΣPAEs的浓度范围分别为0.015 ~ 7.42和0.019 ~ 7.79 μg/L,均以DBP为主(瓶装:7.41±0.35;自来水:7.79±0.35)。天然矿物瓶装水的ΣPAEs含量最高,而自来水的ΣPAEs含量随着建筑楼层高度的增加而降低。此外,确定了贝类的生态风险,但在所有类型的水中,成人/儿童的人类健康风险(口腔/皮肤)仍然很低。尽管PAEs的检出率很高,但人群接触的危险很小。然而,由于与人类活动有关的地表水中PAE含量较高,天然矿物瓶装水和来自较低楼层的自来水需要优先监测。
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引用次数: 0
Acute Inhalation Exposure to Ultrafine Carbon Black Alters Mitochondrial Substrate Utilization in the Heart 急性吸入超细炭黑会改变心脏线粒体底物的利用
IF 4.5 3区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2025-10-31 DOI: 10.1002/tox.24582
William E. Mullen, Jackson E. Stewart, Rahatul Islam, Salik Hussain, Dharendra Thapa
A majority of deaths associated with air pollution are attributed to cardiovascular and heart diseases. Carbon black that represents the carbon core of particulate matter, a major component of air pollution, has been shown to result in cardiac mitochondrial dysfunction. The goal of this study was to identify mechanisms that potentially regulate cardiac mitochondrial function in acute carbon black exposure. Specifically, we examined whether lysine acetylation, a post‐translational modification, impacts cardiac mitochondrial function and contributes to mitochondrial dysfunction observed with carbon black exposure. C57BL/6J animals exposed to 10 mg/m 3 CB for 3 h resulted in a significant increase in acetylation of fatty acid oxidation proteins—long and short chain acyl‐CoA dehydrogenase and hydroxyacyl‐CoA dehydrogenase—which correlated with decreased enzymatic activities. Further, a significant decrease in fatty acid import protein carnitine palmitoyl‐transferase 1b was observed. An increase in acetylation of electron transport chain complexes I and V along with increased Complex V activity was observed in carbon black exposed animals. This decrease in import and utilization of fatty acid metabolism was counteracted by an increase in protein and activity level of glucose oxidation protein pyruvate dehydrogenase. These findings suggest that acute exposure to carbon black results in a switch in substrate utilization from fatty acids to glucose that in turn feeds the electron transport chain process in the exposed heart. Finally, these findings present the potential role of lysine acetylation mediated regulation of mitochondrial dysfunction in the acute carbon black exposed model.
大多数与空气污染有关的死亡归因于心血管和心脏疾病。炭黑是空气污染的主要组成部分,它代表颗粒物质的碳核,已被证明会导致心脏线粒体功能障碍。本研究的目的是确定急性炭黑暴露中可能调节心脏线粒体功能的机制。具体来说,我们研究了赖氨酸乙酰化(一种翻译后修饰)是否会影响心脏线粒体功能,并导致炭黑暴露后观察到的线粒体功能障碍。C57BL/6J动物暴露于10 mg/m的3cb环境3小时后,脂肪酸氧化蛋白(长链和短链酰基-辅酶a脱氢酶和羟基酰基-辅酶a脱氢酶)的乙酰化显著增加,与酶活性降低相关。此外,脂肪酸进口蛋白肉碱棕榈酰转移酶1b显著减少。炭黑暴露动物的电子传递链复合物I和V的乙酰化程度随着复合物V活性的增加而增加。脂肪酸代谢的进口和利用的减少被葡萄糖氧化蛋白丙酮酸脱氢酶的蛋白质和活性水平的增加所抵消。这些发现表明,急性暴露于炭黑会导致底物利用从脂肪酸到葡萄糖的转换,从而为暴露的心脏中的电子传递链过程提供营养。最后,这些发现提出了在急性炭黑暴露模型中赖氨酸乙酰化介导的线粒体功能障碍调节的潜在作用。
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引用次数: 0
RETRACTION: Diallyl Disulfide Antagonizes DJ-1 Mediated Proliferation, Epithelial–Mesenchymal Transition, and Chemoresistance in Gastric Cancer Cells 回顾:二烯丙基二硫醚可拮抗DJ-1介导的胃癌细胞增殖、上皮-间质转化和化疗耐药。
IF 3.2 3区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2025-10-28 DOI: 10.1002/tox.24601

RETRACTION: J. Su, H. Xia, H. He, H. Tang, J. Zhou, Y. Xun, F. Liu, B. Su, and Q. Su, “ Diallyl Disulfide Antagonizes DJ-1 Mediated Proliferation, Epithelial–Mesenchymal Transition, and Chemoresistance in Gastric Cancer Cells,” Environmental Toxicology 39, no. 8 (2024): 41054119, https://doi.org/10.1002/tox.24300.

The above article, published online on 20 April 2024, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, April Rodd; and Wiley Periodicals LLC. Following publication, duplications were noted in Figures 2A, 3E, 6A, and in multiple panels within Figures 5C and 7. Additionally, duplicated panels were discovered for Figure 1 with an earlier publication by some of the same authors (Su et al., 2016 [https://doi.org/10.18632/oncotarget.7252]), and multiple panels in Figure 4D were duplicated from an earlier publication by different authors (Guo et al., 2018 [https://doi.org/10.1002/jcp.26828]). The retraction has been agreed to because of evidence that significant portions of multiple figures were duplicated, affecting the interpretation of the data and results presented.

The authors did not respond to communications from the Publisher regarding the retraction.

引用本文:苏军,夏红,何红,唐红,周军,孙勇,刘峰,苏斌,苏强,“二烯丙基二硫酯对胃癌细胞增殖、上皮-间质转化和化疗耐药的拮抗作用”,《环境毒理学杂志》,第39期,no。8 (2024): 4105-4119, https://doi.org/10.1002/tox.24300。上述文章于2024年4月20日在线发表在Wiley在线图书馆(http://onlinelibrary.wiley.com/)上,经期刊主编April Rodd;和Wiley期刊有限责任公司。出版后,重复在图2A、3E、6A以及图5C和7的多个面板中都有标注。此外,在图1中发现了一些相同作者较早发表的重复面板(Su et al., 2016 [https://doi.org/10.18632/oncotarget.7252]]),图4D中的多个面板是不同作者较早发表的重复面板(Guo et al., 2018 [https://doi.org/10.1002/jcp.26828]])。由于有证据表明多个数字的重要部分被重复,影响了对所呈现的数据和结果的解释,因此同意撤回。作者没有回应出版商关于撤稿的联系。
{"title":"RETRACTION: Diallyl Disulfide Antagonizes DJ-1 Mediated Proliferation, Epithelial–Mesenchymal Transition, and Chemoresistance in Gastric Cancer Cells","authors":"","doi":"10.1002/tox.24601","DOIUrl":"10.1002/tox.24601","url":null,"abstract":"<p>\u0000 \u0000 <b>RETRACTION</b>: <span>J. Su</span>, <span>H. Xia</span>, <span>H. He</span>, <span>H. Tang</span>, <span>J. Zhou</span>, <span>Y. Xun</span>, <span>F. Liu</span>, <span>B. Su</span>, and <span>Q. Su</span>, “ <span>Diallyl Disulfide Antagonizes DJ-1 Mediated Proliferation, Epithelial–Mesenchymal Transition, and Chemoresistance in Gastric Cancer Cells</span>,” <i>Environmental Toxicology</i> <span>39</span>, no. <span>8</span> (<span>2024</span>): <span>4105</span>–<span>4119</span>, https://doi.org/10.1002/tox.24300.\u0000 </p><p>The above article, published online on 20 April 2024, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, April Rodd; and Wiley Periodicals LLC. Following publication, duplications were noted in Figures 2A, 3E, 6A, and in multiple panels within Figures 5C and 7. Additionally, duplicated panels were discovered for Figure 1 with an earlier publication by some of the same authors (Su et al., 2016 [https://doi.org/10.18632/oncotarget.7252]), and multiple panels in Figure 4D were duplicated from an earlier publication by different authors (Guo et al., 2018 [https://doi.org/10.1002/jcp.26828]). The retraction has been agreed to because of evidence that significant portions of multiple figures were duplicated, affecting the interpretation of the data and results presented.</p><p>The authors did not respond to communications from the Publisher regarding the retraction.</p>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"41 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/tox.24601","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145376558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cabomba caroliniana and Schoenoplectus californicus as Antifouling Candidates: Anti-Attachment and Toxicological Effects in Aurelia coerulea (Cnidaria, Scyphozoa). 作为防污候选者的卡罗莱纳卡龙巴和加利福尼亚Schoenoplectus:在刺胞目、棘虫目的蓝纹蝽(Aurelia coerulea)中的抗附着和毒理学效应。
IF 4.5 3区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2025-10-25 DOI: 10.1002/tox.24579
Mikael Luiz Pereira Morales,Laís Olivera das Neves,Ayman Shaik,Hafizah Chenia,Maximiliano Manuel Maronna,Sanye Soroldoni,Renato Mitsuo Nagata,Ng Haig They,Vanessa Ochi Agostini,Grasiela Lopes Leães Pinho
Biofouling on artificial surfaces in aquatic ecosystems leads to significant economic losses. Current antifouling paints, while effective, often harm the aquatic environment. This study explores ecologically safe antifouling alternatives derived from plants, focusing on the aquatic macrophytes Cabomba caroliniana (CC) and Schoenoplectus californicus (SC). While these macrophytes have shown promise against microfouling, their effectiveness against marine macrofouling remains underexplored. For marine macrofouling tests, Aurelia polyps have been recommended due to their availability and handling. Using the marine cnidarian Aurelia coerulea (AC) as a model organism, the ability of CC and SC extracts to inhibit polyp attachment was evaluated as well as their toxicological effects on polyps and ephyrae. Additionally, the sensitivity of AC to substances (surfactant, zinc, and copper) was assessed to determine its sensitivity compared to other organisms. A dose-dependent inhibition of polyp attachment was observed, with up to 65% efficacy. Toxicity tests indicated low toxicity at concentrations of up to 5% for CC and 20% for SC. The main compounds identified were n-nonadecanol-1 for CC and eicosane for SC. Additionally, AC proved to be a versatile anti-attachment assay model, offering advantages such as sensitivity to chronic and acute tests, dual life stages, and short assay times of up to 72 h. These results suggest the biotechnological potential of CC and SC as natural antifouling agents and highlight their suitability for developing environmentally friendly antifouling applications.
水生生态系统人工表面的生物污染会导致重大的经济损失。目前的防污涂料虽然有效,但往往会危害水生环境。本研究探索了从植物中提取的生态安全的防污替代品,重点是水生植物卡罗莱纳卡罗莱纳卡(CC)和加利福尼亚Schoenoplectus (SC)。虽然这些大型植物已经显示出对抗微污染的希望,但它们对抗海洋大污染的有效性仍未得到充分探讨。对于海洋大污染测试,由于其可获得性和处理性,推荐使用水螅。以海洋刺胞动物蓝纹水母(Aurelia coerulea, AC)为模型生物,研究了CC和SC提取物对息肉附着的抑制作用以及对息肉和藻的毒理学作用。此外,还评估了AC对物质(表面活性剂、锌和铜)的敏感性,以确定其与其他生物的敏感性。观察到对息肉附着的剂量依赖性抑制,疗效高达65%。毒性试验表明,CC浓度为5%时毒性较低,SC浓度为20%时毒性较低。鉴定出的主要化合物是CC的正壬烷醇-1和SC的二十烷。此外,AC被证明是一种通用的抗附着试验模型,具有对慢性和急性试验敏感、双生命阶段和短检测时间(可达72小时)等优点。这些结果表明了CC和SC作为天然防污剂的生物技术潜力,并强调了它们在开发环境友好型防污应用方面的适用性。
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引用次数: 0
Exploring the Impact of Polystyrene Microplastic Beads on Male Gonads of the Marine Mussel, Mytilus galloprovincialis. 聚苯乙烯微塑料微珠对海洋贻贝雄性性腺的影响。
IF 4.5 3区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2025-10-25 DOI: 10.1002/tox.24581
Teresa Chianese,Mariachiara Galati,Tiziana Cappello,Maria Maisano,Gennaro Lettieri,Carmela Marinaro,Marina Piscopo,Gianluca Fasciolo,Carlos Gravato,Gaetana Napolitano,Giulia Paolella,Annamaria Locascio,Rosaria Scudiero,Luigi Rosati
Plastic, with its remarkable versatility and numerous applications, has greatly benefited humanity. However, its extreme resistance to natural degradation means it persists in the environment for long periods, causing global environmental problems. Furthermore, the fragmentation of plastic waste leads to the formation of microplastics (MP), which are minuscule particles that can accumulate in aquatic ecosystems. This poses a threat to marine fauna and, indirectly, to humans, as it also endangers the reproductive health of individuals. This study aimed to investigate the effects of microplastics on the structure and function of the testis of Mytilus galloprovincialis, chosen as a model species for its ecological and commercial relevance. Mussels were exposed for 48 h to 5 μm polystyrene MPs at two concentrations (0.5 and 1 μg/mL), then the testes were subjected to morphological and molecular analyses. Morphological analyses revealed that MPs alter the structure of the sperm cyst in a dose-dependent manner, disrupting cellular interactions between germ cells. These structural deviations may be linked to contact damage and the onset of oxidative stress. Alongside specific histological staining, this condition is primarily demonstrated through biochemical, molecular, and metabolic investigations. Metabolomics, based on proton nuclear magnetic resonance (1H NMR), combined with chemometrics, made it possible to comprehensively explore the time-dependent metabolic disturbances triggered by MPs in the gonads of mussels during the short-term study. Ultimately, the dose-dependent stress condition caused by MPs also disrupts the proper chromatin folding of spermatozoa. This suggests that these particles, in addition to hindering gametogenesis, may also impact the fertilizing capacity of these cells.
塑料以其卓越的多功能性和众多的用途,极大地造福了人类。然而,它对自然退化的极强抵抗力意味着它会长期存在于环境中,造成全球环境问题。此外,塑料垃圾的碎片化导致微塑料(MP)的形成,这是一种可以在水生生态系统中积累的微小颗粒。这对海洋动物构成威胁,并间接对人类构成威胁,因为它也危及个人的生殖健康。本研究旨在研究微塑料对Mytilus galloprovincialis睾丸结构和功能的影响,该物种因其生态和商业意义而被选为模式物种。将5 μm聚苯乙烯MPs(0.5和1 μg/mL)对贻贝暴露48 h,对其睾丸进行形态和分子分析。形态学分析显示,MPs以剂量依赖的方式改变精子囊肿的结构,破坏生殖细胞之间的细胞相互作用。这些结构偏差可能与接触损伤和氧化应激的发生有关。除了特定的组织学染色外,这种情况主要通过生化、分子和代谢调查来证明。代谢组学以质子核磁共振(1H NMR)为基础,结合化学计量学,可以在短期研究中全面探索MPs在贻贝性腺中引发的时间依赖性代谢紊乱。最终,MPs引起的剂量依赖性应激条件也破坏了精子正常的染色质折叠。这表明,这些颗粒除了阻碍配子体发生外,还可能影响这些细胞的受精能力。
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引用次数: 0
Evaluation of Biological Effects of Nanoneedle Calcium Carbonate Crystals Used for Water Treatment. 纳米针状碳酸钙晶体用于水处理的生物效应评价。
IF 4.5 3区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2025-10-25 DOI: 10.1002/tox.24578
Masanori Horie,Nobuaki Negishi
Aragonite nanoneedles were synthesized for use in purifying drinking water via a mechano-bactericidal effect, and the biological effects of this aragonite and the calcium carbonate compounds produced during its synthesis were evaluated. Three types of cells (intestinal epithelial-derived Caco-2 cells, keratinocyte-derived HaCaT cells, and macrophage-differentiated THP-1 cells) were exposed to four types of calcium carbonate compound suspensions containing aragonite nanoneedles. No effects on cell viability were observed for any of the cells. However, at a high concentration of 1000 mg/mL, cell membrane damage was observed. In particular, cell membrane damage was observed in THP-1 cells. The acicular calcium carbonate samples also significantly induced IL-8 expression in THP-1 cells. In particular, one of the calcium carbonate compounds significantly promoted the expression of IL-8, TNF-α, MCP-1, and IL-1β. In THP-1 cells, an increase in intracellular calcium levels was also observed. These in vitro results suggest that calcium carbonate-containing aragonite nanoneedles have the potential to induce inflammation. To confirm that inflammation is actually induced in the body, in vivo examinations were performed. These acicular calcium carbonate suspensions were administered intraperitoneally to C57BL/6N mice. Serum cytokines were measured 1 and 3 months later. No significant difference in effect was observed among the samples. Pathological observations also showed no induction of inflammation. These results suggest that acicular calcium carbonate has the potential to induce cytokine secretion by macrophages, but that its in vivo effects are limited. At the levels present in drinking water, the effects of acicular calcium carbonate are likely to be small. These findings pave the way for the application of aragonite nanoneedles in water purification, potentially contributing to the resolution of drinking water challenges, particularly in developing countries.
利用机械杀菌作用合成了用于饮用水净化的文石纳米针,并评价了该文石及其合成过程中产生的碳酸钙化合物的生物效应。将三种类型的细胞(肠上皮来源的Caco-2细胞、角化细胞来源的HaCaT细胞和巨噬细胞分化的THP-1细胞)暴露于含有文石纳米针的四种碳酸钙化合物悬浮液中。未观察到任何细胞活力受到影响。然而,在1000 mg/mL的高浓度下,观察到细胞膜损伤。特别是在THP-1细胞中观察到细胞膜损伤。针状碳酸钙样品也显著诱导THP-1细胞中IL-8的表达。其中一种碳酸钙化合物显著促进了IL-8、TNF-α、MCP-1和IL-1β的表达。在THP-1细胞中,也观察到细胞内钙水平升高。这些体外实验结果表明,含碳酸钙文石纳米针具有诱导炎症的潜力。为了证实炎症实际上是在体内引起的,进行了体内检查。这些针状碳酸钙悬浮液被腹腔注射给C57BL/6N小鼠。1、3个月后测定血清细胞因子。样本间的效果无显著差异。病理观察也未见炎症诱导。这些结果表明,针状碳酸钙具有诱导巨噬细胞分泌细胞因子的潜力,但其在体内的作用有限。在饮用水中存在的水平,针状碳酸钙的影响可能很小。这些发现为文石纳米针在水净化中的应用铺平了道路,可能有助于解决饮用水挑战,特别是在发展中国家。
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引用次数: 0
RETRACTION: The Estrogen/miR-338-3p/ADAM17 Axis Enhances the Viability of Breast Cancer Cells Via Suppressing NK Cell's Function 撤回:雌激素/miR-338-3p/ADAM17轴通过抑制NK细胞功能增强乳腺癌细胞活力
IF 3.2 3区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2025-10-24 DOI: 10.1002/tox.24593

RETRACTION: Y. Shi, J. Pan, C. Hang, L. Tan, L. Hu, Z. Yan, and J. Zhu, “ The Estrogen/miR-338-3p/ADAM17 Axis Enhances the Viability of Breast Cancer Cells Via Suppressing NK Cell's Function,” Environmental Toxicology 38, no. 7 (2023): 16181627, https://doi.org/10.1002/tox.23791.

The above article, published online on 13 April 2023 in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, April Rodd; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted.

The authors did not respond to communications from the Publisher regarding the retraction.

引用本文:石艳,潘军,韩超,谭莉,胡丽,闫志杰,朱军,“雌激素/miR-338-3p/ADAM17轴通过抑制NK细胞功能增强乳腺癌细胞活力”,环境毒理学杂志,38,no. 6。7 (2023): 1618-1627, https://doi.org/10.1002/tox.23791。上述文章于2023年4月13日在线发表在Wiley在线图书馆(http://onlinelibrary.wiley.com/)上,经期刊主编April Rodd;和Wiley期刊有限责任公司。经过出版商的调查,双方得出结论,这篇文章完全是在妥协的同行评议过程的基础上被接受的。因此,这篇文章必须撤回。作者没有回应出版商关于撤稿的联系。
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引用次数: 0
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Environmental Toxicology
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