Maria Karolina Martins Ferreira, Deiweson Souza‐Monteiro, Priscila Cunha Nascimento, Luciana Eiró‐Quirino, Leonardo Oliveira Bittencourt, Fatemeh Vida Zohoori, Esperanza Angeles Martinez‐Mier, Marilia Afonso Rabelo Buzalaf, Rafael Rodrigues Lima
This study analyzed research trends in the 100 most‐cited articles on fluoride toxicology, a topic widely debated due to the toxic effects associated with levels deemed safe for human exposure. A bibliometric analysis was conducted using the Web of Science‐Core Collection, extracting data such as citation count, authors, keywords, journal, publication year, country, and continent. After reviewing the studies, additional information—including study design, investigated organs and tissues, main outcomes, and fluoride levels—was obtained. The initial search retrieved 5983 articles, from which the 100 most‐cited were selected, totaling 16 813 citations. The journal Fluoride published the highest number of articles ( n = 9), with keywords like “fluoride,” “fluorosis,” “dental fluorosis,” and “oxidative stress” being the most prevalent. India and China accounted for the largest share of publications. The most common study types were observational studies, literature reviews, and in vitro studies. Several studies reported fluoride's effects on dental and skeletal fluorosis, as well as damage to the brain, thyroid, gastrointestinal tract, heart, liver, kidneys, and specific cell types. This study highlights significant concerns regarding excessive fluoride exposure and identifies key research trends and gaps, particularly in the understanding of molecular mechanisms underlying fluoride‐induced damage.
本研究分析了100篇被引用最多的氟化物毒理学文章的研究趋势,由于与人体暴露安全水平相关的毒性影响,氟化物毒理学是一个广泛争论的话题。使用Web of Science‐Core Collection进行文献计量学分析,提取引文计数、作者、关键词、期刊、出版年份、国家和大洲等数据。在回顾了这些研究之后,获得了更多的信息,包括研究设计、调查的器官和组织、主要结果和氟化物水平。最初的检索检索了5983篇文章,从中选出了被引用次数最多的100篇,共被引用16813次。《氟化物》杂志发表的文章数量最多(n = 9),其中“氟化物”、“氟中毒”、“氟牙症”和“氧化应激”等关键词最为普遍。印度和中国占据了出版物的最大份额。最常见的研究类型是观察性研究、文献综述和体外研究。几项研究报告了氟化物对牙齿和骨骼氟中毒的影响,以及对大脑、甲状腺、胃肠道、心脏、肝脏、肾脏和特定细胞类型的损害。本研究强调了对过量氟化物暴露的重大关注,并确定了关键的研究趋势和差距,特别是在理解氟化物诱导损伤的分子机制方面。
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