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2009 14th National Biomedical Engineering Meeting最新文献

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Estimation of state transition matrix in the Kalman filter based inverse ECG solution with the help of training sets 基于训练集的卡尔曼滤波心电反解状态转移矩阵估计
Pub Date : 2009-05-20 DOI: 10.1109/BIYOMUT.2009.5130254
Umit Aydin, Y. Serinağaoğlu
At this study the main motivation is to solve inverse problem of ECG with Kalman filter. In order to obtain feasible solutions determination of the state transition matrix (STM) correctly is vital. In literature the STM is usually found by using the test data itself which is not a realistic scenario. The major goal of this study is to determine STM without using test data. For that purpose a two stage method is suggested. At the first step the probability density function (pdf) is calculated using training sets and then this pdf is used to find Bayes-MAP solution which uses only spatial information. At the second step, the Bayes-MAP solution is used to find STM and later on, that STM is used in Kalman filter to obtain final results. It is seen that the results obtained with this method are better then normal Bayes-MAP results and the errors are within acceptable limits. So it is concluded that the usage of Bayes-MAP solutions in STM determination is a serious alternative for STM estimation.
本研究的主要目的是利用卡尔曼滤波解决心电信号的逆问题。为了得到可行的解,正确确定状态转移矩阵至关重要。在文献中,STM通常是通过使用测试数据本身来发现的,这不是一个现实的场景。本研究的主要目的是在不使用测试数据的情况下确定STM。为此,建议采用两阶段方法。首先使用训练集计算概率密度函数(pdf),然后使用该pdf找到仅使用空间信息的Bayes-MAP解。第二步,使用Bayes-MAP解找到STM,然后将STM用于卡尔曼滤波,得到最终结果。结果表明,该方法得到的结果优于普通的Bayes-MAP结果,误差在可接受的范围内。因此,在STM确定中使用Bayes-MAP解是STM估计的重要替代方案。
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引用次数: 1
Extraction of the liver vessels from the abdomen CTA images by Hessian-based vessel filter 基于hessian的血管滤波从腹部CTA图像中提取肝脏血管
Pub Date : 2009-05-20 DOI: 10.1109/BIYOMUT.2009.5130311
H. Dogan, O. Dicle, C. Guzelis
Prior to the liver transplantation and tumor resection operations, the extraction of the vessel system which specifies the segments of the liver, from the Computed Tomography Angiography (CTA) images is an important organ segmentation task. In this paper, the computer experiment results on the application of the Hessian based vessel filter for the extraction of the liver vessels and the labeling of the main vessels are presented.
在肝移植和肿瘤切除手术之前,从ct血管造影(CTA)图像中提取指定肝脏各部分的血管系统是一项重要的器官分割任务。本文给出了基于Hessian的血管过滤器在肝脏血管提取和主要血管标记中的计算机实验结果。
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引用次数: 2
Examining the relevance with sleep stages of time domain features of EEG, EOG, and chin EMG signals 研究脑电图、眼电图和颏肌电图信号的时域特征与睡眠阶段的相关性
Pub Date : 2009-05-20 DOI: 10.1109/BIYOMUT.2009.5130256
S. Gune, K. Polat, M. Dursun, Ş. Yosunkaya
Sleep staging has an important role in determining sleep disorders such as sleepiness, human fatigue etc. Sleep staging is generally done according to Rechtschaffen and Kales standard (RKS) using EEG signal obtained from PSG signals taken from patient subjects who come with any sleep disorders. Sleep stages are generally divided into three stages including awake, REM and N-REM (stage 1, stage 2, and stage 3). In this study, time domain features of EEG, EOG of right and left eyes, and chin EMG signals belonging to sleep stages were investigated and correlation between these time domain features and sleep stages was calculated. The used time domain features are mean value, standard deviation, peak value, skewness, kurtosis, and shape factor belonging to EEG, EOG of right and left eyes, and chin EMG signals. In experimental studies, PSG recordings of 3 subjects were taken and average recording time of 6.22 h, total recording time was 18.67 h. When investigated correlation coefficients, it is seen that skewness feature in time domain features of EEG signal, standard deviation feature in time domain features of EOG signals belonging to right and left eyes, and mean value feature in time domain features of chin EMG signal were more correlated with sleep stages than other features. Consequently, a feature vector can be constituted combining features determined from time domain features of EEG, EOG belonging to right and left eyes, and chin EMG signals. This obtained feature vector can be easily used in distinguishing sleep stages.
睡眠阶段在决定睡眠障碍(如嗜睡、人体疲劳等)方面起着重要作用。睡眠分期通常根据Rechtschaffen和Kales标准(RKS)进行,使用从患有任何睡眠障碍的患者受试者的PSG信号中获得的脑电图信号。睡眠阶段一般分为清醒、快速眼动和n -快速眼动三个阶段(第一阶段、第二阶段和第三阶段)。本研究研究了属于睡眠阶段的EEG、左右眼EOG和颏肌电信号的时域特征,并计算了这些时域特征与睡眠阶段的相关性。所使用的时域特征是EEG、左右眼EOG和颏肌电信号的均值、标准差、峰值、偏度、峰度和形状因子。在实验研究中,采集了3名被试的PSG记录,平均记录时间为6.22 h,总记录时间为18.67 h。在研究相关系数时,发现脑电信号时域特征的偏态特征、右眼和左眼EEG信号时域特征的标准差特征以及颏肌电信号时域特征的均值特征与睡眠阶段的相关性大于其他特征。由此,将EEG、左右眼EOG和颏肌电信号的时域特征组合成特征向量。得到的特征向量可以很容易地用于睡眠阶段的区分。
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引用次数: 11
Design and fabrication of a chaotic mixer for BioMEMS applications 生物机械系统混沌混频器的设计与制造
Pub Date : 2009-05-20 DOI: 10.1109/BIYOMUT.2009.5130268
G. Yilmaz, E. Bayraktar, H. Kulah
Since fabrication of microchips by MEMS technology has emerged, microchips that can interact with biological samples like virus, bacteria, DNA has been developed. Considering the advantages such as cost, dimension and compatibility with IC fabrication, these chips have found specific application areas. Microfluids and microfluidics constitute one of the major research areas of this emerging field, BioMEMS. Micro mixers have become an important component of BioMEMS which are designed for microfluidics applications. Fluids demonstrate two types of flow regime, laminar and turbulent. Turbulent flow is more advantageous than laminar flow when mixing is considered. Creating turbulent flow within microchannels, commonly used in BioMEMS devices, is a challenging task as scaling into the micro domain causes fluids to mix solely by diffusion. This study presents a method for mixing in micro environment based on chaotic advection. The proposed micro mixer makes use of the turbulent flow induced by bubbles which are created by thermal actuation based on joule heating principle on gold electrodes.
随着利用MEMS技术制造微芯片的出现,可以与病毒、细菌、DNA等生物样品相互作用的微芯片已经被开发出来。考虑到成本、尺寸和与集成电路制造的兼容性等优势,这些芯片已经找到了特定的应用领域。微流体和微流体构成了生物医学领域这个新兴领域的主要研究领域之一。微混合器已成为生物医学系统的重要组成部分,它是为微流体应用而设计的。流体表现出两种流动形式,层流和湍流。当考虑混合时,湍流比层流更有利。通常用于BioMEMS设备的微通道内产生湍流是一项具有挑战性的任务,因为缩放到微域会导致流体仅通过扩散混合。提出了一种基于混沌平流的微环境混合方法。本文提出的微型混合器利用了基于焦耳加热原理的热致动在金电极上产生气泡所引起的湍流。
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引用次数: 0
Improvement of mechanical performances by plasma polymerisation technique for composite biomaterials 等离子体聚合技术对复合生物材料力学性能的改善
Pub Date : 2009-05-20 DOI: 10.1109/BIYOMUT.2009.5130313
Tuba Durmaz, S. Erkut, Dilek Cokeliler
In recent years, fibers are used for improving mechanical strength of acrylic-based resin which used for construction of protheses frequently. Improvement of the fiber- matrix interfase is a very important approach at redevelopment of mechanical properties. In this study, glass fibers are modified by radiofrequency (RF) plasma technique with using different monomers. Silane based monomer glisitoxypropyltrimethiloxysilane and amine based ethylenediamine (EDA)are polimerized on the glass fibers in plasma environment for application of two different approaches (hydrophobic/hydrophobic). Surface modification application is optimized with increasing power and exposure time parameters, which are used for low vacuum RF glow discharge. The change of surface properties for glass fibers are characterized by measurement of static contact angle and bending strain of fiber-acrylic composites are measured with 3 point bending device. While the cost of bending strain of the composites, which is prepared by virgin glass fibers, is 127.9±9 MPa, the maximum mechanical strength has been obtained at amine based plasma polymerization technique (150.2±4 MPa). The mechanical strenght is improved according to the working parameters that are used in silane based plasma polymerisation technique (141.2±7 MPa, power: 40W, Exposure Time: 30 min) It's proved with contact angle measurement that gaining less hydrofobic property to the surface is an appropriate approach.
近年来,纤维被广泛用于提高丙烯酸基树脂的机械强度,丙烯酸基树脂经常用于假体的建造。改善纤维基界面是提高材料力学性能的重要途径。本研究采用射频等离子体技术,采用不同的单体对玻璃纤维进行改性。以硅烷基单体glisitoxypropyltrimethiloxysilane和胺基乙二胺(EDA)为材料,在等离子体环境下在玻璃纤维上进行了疏水/疏水两种不同途径的聚合。随着功率和曝光时间参数的增加,优化了表面改性应用,用于低真空射频辉光放电。通过静态接触角的测量来表征玻璃纤维表面性能的变化,并利用三点弯曲装置测量了纤维-丙烯酸复合材料的弯曲应变。由原始玻璃纤维制备的复合材料的弯曲应变成本为127.9±9 MPa,而胺基等离子体聚合技术获得的最大机械强度为150.2±4 MPa。根据硅烷基等离子体聚合技术的工作参数(141.2±7 MPa,功率:40W,曝光时间:30 min),提高了材料的机械强度,并通过接触角测量证明了减少表面的疏水性是一种合适的方法。
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引用次数: 1
Design and Implementation of Electrospinning System 静电纺丝系统的设计与实现
Pub Date : 2009-05-20 DOI: 10.1109/BIYOMUT.2009.5130365
Mustafa Doğan, Okan Karatay, Dilek Cokeliler, I. Kocum
Various methods for fabricating nanoscale polymeric fibers are investigated at large, e.g. tissue engineering . Electrospinning is the most versatile process among them. Materials such as polymer, composites and metal nanofibres have been fabricated with electrospinning techniques. It is important that many parameters and post, pre-processes should be investigated thoroughly to be able to optimize the method. Characteristics of the electrostatic field, and polymer solution constitute the main design criteria. The proposed experimental setup has been implemented with newly designed high voltage power suply which can be adjusted resiliently in frequency and power amplitude.
各种制造纳米级聚合物纤维的方法被广泛研究,例如组织工程。静电纺丝是其中用途最广的一种工艺。聚合物、复合材料和金属纳米纤维等材料已经用静电纺丝技术制造出来。重要的是,许多参数和后,预处理应彻底调查,以便能够优化方法。静电场和聚合物溶液的特性构成了主要的设计准则。实验装置采用新设计的可弹性调节频率和功率幅值的高压电源。
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引用次数: 1
The effects of classical and turkish music samples on the Autonomic Nervous System 古典和土耳其音乐样本对自主神经系统的影响
Pub Date : 2009-05-20 DOI: 10.1109/BIYOMUT.2009.5130363
M. Yıldız, D. Yilmaz
In this study, 27 young and healthy subjects was listening to the classical and Turkish music samples which are believed to changeable the subject's emotional state. Their effects on Autonomic Nervous System (ANS) are investigated by using the heart rate variability (HRV) analysis which is accepted as a non-invasive indicator of ANS. The electrocardiogram (ECG) and respiration records were made before and during the listening music samples. Heart rate variability (HRV) signals are obtained form records and power spectral densities (PSD) of HRV are estimated. According to the results of calculated parameters, during the listening to classical music samples some statistically significant changes were occurred in sympathetic and parasympathetic activities of ANS. Turkish music samples were not causes significant differences on the ANS related HRV parameters.
在本研究中,27名年轻健康的受试者听古典音乐和土耳其音乐样本,这些样本被认为可以改变受试者的情绪状态。采用心率变异性(HRV)分析研究其对自主神经系统(ANS)的影响,心率变异性被认为是自主神经系统(ANS)的无创指标,并在听歌前和听歌过程中记录心电图和呼吸。通过记录获得心率变异性信号,并估计心率变异性的功率谱密度(PSD)。根据计算参数的结果,在古典音乐样本的聆听过程中,ANS的交感神经和副交感神经活动发生了一些有统计学意义的变化,土耳其音乐样本在ANS相关HRV参数上没有引起显著差异。
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引用次数: 1
Frequency following brain oscillations evoked by vibrotactile stimulation of the distal phalanx in normal subjects 正常人远端指骨触觉振动刺激引起的脑振荡的频率
Pub Date : 2009-05-20 DOI: 10.1109/BIYOMUT.2009.5130376
Duygu Torun, M. Yıldız, Burak Guclu
The sensory response upon vibrotactile stimuli is still not entirely understood. Previously, the responses of single units from mechanoreceptive afferents and cortical neurons have been studied. There is a thorough psychophysical literature on judgements of the presence, magnitude, and frequency of vibrotactile stimuli [1–3]. However, non-invasive recording of evoked responses on the scalp have solely been determined for electrical stimuli.In this study, psychophysical detection thresholds of adult subjects were measured at various mechanical frequencies. These values were found to be consistent with the literature. To measure the frequency following brain responses, stimulus intensities were determined based on psychophysical sensation levels. Data recorded from the somatosensory cortex area via electrodes placed on scalp, were analysed with wavelet transform. The results show that, as the mechanical stimulus intensity was increased, the background activity was suppressed and the frequency-following activity during stimulus period increased. This finding was statistically significant
对振动触觉刺激的感觉反应仍未完全理解。在此之前,已经研究了来自机械感受传入和皮质神经元的单个单元的反应。关于触觉振动刺激的存在、大小和频率的判断,有大量的心理物理学文献[1-3]。然而,头皮上的诱发反应的非侵入性记录仅被确定为电刺激。在本研究中,测量了成人受试者在不同机械频率下的心理物理检测阈值。这些值被发现与文献一致。为了测量大脑反应后的频率,刺激强度是根据心理物理感觉水平确定的。通过放置在头皮上的电极从体感觉皮层区域记录的数据,用小波变换进行分析。结果表明,随着机械刺激强度的增加,刺激期的背景活动被抑制,频率跟随活动增加。这一发现具有统计学意义
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引用次数: 0
Design and application of a sol-gel based fluorescent glucose arrays 基于溶胶-凝胶的荧光葡萄糖阵列的设计与应用
Pub Date : 2009-05-20 DOI: 10.1109/BIYOMUT.2009.5130305
Nimet Yildirim, Dilek Odaci, Gulsiye Ozturk, S. Alp, Y. Ergun, K. Feller, K. Dornbusch, S. Timur
Here we present a new sol-gel based fluorescent glukoz biosensor. The sensor is based on the pH sensitive fluorescent dye entrapped in a tetraethoxysilane (TEOS) based sol-gel together with glukoz oxidase. Micro-analytic sustem which can measure the pH induced chance in the fluorescens intensity due to the enzymatic reaction in spotted layer on the glass surface was used as a measuring system. The system was calibrated to glukoz. As well as characterization, glukoz biosensing in such fruit juice samples were carried out.
本文提出了一种基于溶胶-凝胶的荧光葡萄糖生物传感器。该传感器是基于pH敏感的荧光染料包裹在四乙氧基硅烷(TEOS)为基础的溶胶-凝胶与葡萄糖氧化酶。采用微分析系统测量玻璃表面斑点层中酶促反应引起荧光强度pH值变化的机会。该系统被校准为glukoz。在进行表征的同时,还对此类果汁样品进行了葡萄糖生物传感。
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引用次数: 0
Effect of temperature on electrochemically deposited HAP films on CoCrMo substrate 温度对CoCrMo衬底电化学沉积HAP膜的影响
Pub Date : 2009-05-20 DOI: 10.1109/BIYOMUT.2009.5130325
Pinar Koymen Cagar, N. F. Ak Azem, U. Malayoğlu, A. Cakir
Biomaterials are compatible with neighbouring tissues while implanted in body and do not cause any undesirable reactions such as coagulation and inflammation. Metallic biomaterials have found wide spread application as orthopedic prosthesis and dental implants due to their high strength, great biocompatibility and corrosion durability. But their acceptance by the living tissues in the body is very difficult, if not impossible, as they are bioinert. It is a widespread method to coat the metallic implant surfaces with bioactive ceramic films in order to increase their compatibility and improve bone apposition in the body. Although various calcium phosphate (CaP) based bioactive ceramic compounds with structure similar to the bone exist, hydroxyapatite (HAP) coatings, that has approximately the same composition with biological apatite in the body, create interests in recent years. In this study HAP films coated by electrochemical deposition method on CoCrMo implant materials and effect of solution temperature on the films were determined.
生物材料在植入体内时与邻近组织相容,不会引起凝血和炎症等不良反应。金属生物材料以其高强度、良好的生物相容性和耐腐蚀性能在骨科修复和牙种植体中得到了广泛的应用。但由于它们是生物惰性物质,即使不是不可能,也很难被体内的活组织所接受。在金属种植体表面涂覆生物活性陶瓷膜是一种广泛的方法,以增加它们的相容性和改善骨在体内的附着。虽然存在多种结构与骨相似的磷酸钙(CaP)基生物活性陶瓷化合物,但与体内生物磷灰石成分相近的羟基磷灰石(HAP)涂层近年来引起了人们的关注。本研究采用电化学沉积法在CoCrMo植入材料上制备HAP膜,并测定了溶液温度对HAP膜的影响。
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引用次数: 0
期刊
2009 14th National Biomedical Engineering Meeting
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