Refaettin Şahi̇n, Atakan Tanacan, Hakkı Şerbetçi̇, Osman Onur Özkavak, Murat Haksever, Mehmet Utku Başarir, Özgür Kara, Dilek Sahi̇n
Objective: Our aim is to evaluate the role of the ratio of first-trimester CRL (crown rump length) measurement to NT (nuchal translucency) measurements in predicting early-onset fetal growth restriction (FGR) and to contribute to the existing literature. Methods: In the present case-control study, fetuses with early-onset FGR were compared to a frequency matched low risk control group. This study was conducted in the perinatology clinic of Ankara Bilkent City Hospital between 2020 and 2023. Maternal age, gravidity, parity, crown-rump length (CRL), and nuchal translucency (NT) measurements were compared between pregnant women with early onset FGR (n=39) and pregnant women without FGR (n=50). Results: The mean age of pregnant women with FGR who participated in the study was 27.1±0.8, and the mean age of pregnant women without FGR was 26.3±0.6, and no statistically significant difference was found between the two groups (p=0.4)). Mean CRL was 54.98±1.08 mm in the group with FGR and 56.99±1.11 mm in the group without FGR; there was no significant difference between the two groups (p=0.2). The NT value was 1.11 ± 0.04 mm in the FGR group and 1.13 ± 0.02 mm in the without FGR group, there was no significant difference between the two groups (p=0.73). The mean CRL/NT ratio was 52.00±2.33 in the group with early onset FGR and 51.46±1.48 in the group without FGR and there was no statistically significant difference between the two groups (p=0.83). When the early developing FGR group is evaluated within itself, the mean age at diagnosis was 31.7±0.3 weeks. EFW mean percentile at diagnosis was 4.5±0.6 and ac percentile was 2.9±0.4. The mean umbilical artery systole/diastole ratio (UA-SD) was 2.9±0.16 and the mean umbilical artery pulsatility index (UA-PI) was 1.02±0.05. Conclusion: Crown-rump length to nuchal translucency ratio is not clinically useful to predict early-onset FGR.
{"title":"Erken başlangıçlı fetal büyüme kısıtlamasını (FGR) öngörmede ilk trimester CRL (baş popo mesafesi) ölçümünün NT (ense saydımlığı) ölçümlerine oranının rolü","authors":"Refaettin Şahi̇n, Atakan Tanacan, Hakkı Şerbetçi̇, Osman Onur Özkavak, Murat Haksever, Mehmet Utku Başarir, Özgür Kara, Dilek Sahi̇n","doi":"10.38136/jgon.1397142","DOIUrl":"https://doi.org/10.38136/jgon.1397142","url":null,"abstract":"Objective: Our aim is to evaluate the role of the ratio of first-trimester CRL (crown rump length) measurement to NT (nuchal translucency) measurements in predicting early-onset fetal growth restriction (FGR) and to contribute to the existing literature. \u0000Methods: In the present case-control study, fetuses with early-onset FGR were compared to a frequency matched low risk control group. This study was conducted in the perinatology clinic of Ankara Bilkent City Hospital between 2020 and 2023. Maternal age, gravidity, parity, crown-rump length (CRL), and nuchal translucency (NT) measurements were compared between pregnant women with early onset FGR (n=39) and pregnant women without FGR (n=50). \u0000Results: The mean age of pregnant women with FGR who participated in the study was 27.1±0.8, and the mean age of pregnant women without FGR was 26.3±0.6, and no statistically significant difference was found between the two groups (p=0.4)). Mean CRL was 54.98±1.08 mm in the group with FGR and 56.99±1.11 mm in the group without FGR; there was no significant difference between the two groups (p=0.2). The NT value was 1.11 ± 0.04 mm in the FGR group and 1.13 ± 0.02 mm in the without FGR group, there was no significant difference between the two groups (p=0.73). The mean CRL/NT ratio was 52.00±2.33 in the group with early onset FGR and 51.46±1.48 in the group without FGR and there was no statistically significant difference between the two groups (p=0.83). \u0000When the early developing FGR group is evaluated within itself, the mean age at diagnosis was 31.7±0.3 weeks. EFW mean percentile at diagnosis was 4.5±0.6 and ac percentile was 2.9±0.4. The mean umbilical artery systole/diastole ratio (UA-SD) was 2.9±0.16 and the mean umbilical artery pulsatility index (UA-PI) was 1.02±0.05. \u0000Conclusion: Crown-rump length to nuchal translucency ratio is not clinically useful to predict early-onset FGR.","PeriodicalId":119624,"journal":{"name":"Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140494904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zehra ÖZTÜRK BAŞARIR, S. Ayhan, T. Arslanca, Bülent Özdal
Amaç: Hipertermik intraperitoneal kemoterapi (HİPEK), ileri evre over kanserlerinde uygulanan tedavi yöntemidir. Isı ile birlikte kanser ilaçlarının doğrudan periton içerisine verilerek sitoredüktif cerrahi ile birlikte peritoneal metastazların kontrolünü amaçlar. Çalışmamızda ileri evre over kanseri tanısı alıp primer sitoredüktif cerrahi ile tedavi edilen ve nüks sonrası sekonder sitoredüksiyon + HİPEK uygulaması ile tedavi edilen hastaların ilk tedavi sırasındaki klinikopatolojik özellikleri ile sağkalım arasındaki ilişkiyi incelemeyi amaçlamaktadır Gereç ve Yöntem: İleri evre over kanserinin primer tedavisi sonrası nüks tespit edilen ve sekonder sitoredüktif cerrahi ve beraberinde HİPEK ile tedavi edilen hastalar retrospektif olarak incelenmiştir. Hastaların demografik özellikleri, evreleri, laboratuvar ve klinik seyirleri retrospektif olarak incelenmiştir. Bulgular: HİPEK ile tedavi edilen toplam 29 nüks ileri evre over kanseri hastası dahil edilmiştir. Primer cerrahi sırasında sekiz olguda R0, 20 olguda R1 ve bir hastada R2 rezeksiyon mevcuttur.. R0 rezeksiyon uygulanan hastalarda istatistiksel olarak anlamlı şekilde daha yüksek sağkalım oranı gözlenmiştir (p
{"title":"Factors Effecting on Hyperthermic Intraperitoneal Chemotherapy in Advanced Recurrent Ovarian Cancer","authors":"Zehra ÖZTÜRK BAŞARIR, S. Ayhan, T. Arslanca, Bülent Özdal","doi":"10.38136/jgon.1397682","DOIUrl":"https://doi.org/10.38136/jgon.1397682","url":null,"abstract":"Amaç: Hipertermik intraperitoneal kemoterapi (HİPEK), ileri evre over kanserlerinde uygulanan tedavi yöntemidir. Isı ile birlikte kanser ilaçlarının doğrudan periton içerisine verilerek sitoredüktif cerrahi ile birlikte peritoneal metastazların kontrolünü amaçlar. Çalışmamızda ileri evre over kanseri tanısı alıp primer sitoredüktif cerrahi ile tedavi edilen ve nüks sonrası sekonder sitoredüksiyon + HİPEK uygulaması ile tedavi edilen hastaların ilk tedavi sırasındaki klinikopatolojik özellikleri ile sağkalım arasındaki ilişkiyi incelemeyi amaçlamaktadır \u0000Gereç ve Yöntem: İleri evre over kanserinin primer tedavisi sonrası nüks tespit edilen ve sekonder sitoredüktif cerrahi ve beraberinde HİPEK ile tedavi edilen hastalar retrospektif olarak incelenmiştir. Hastaların demografik özellikleri, evreleri, laboratuvar ve klinik seyirleri retrospektif olarak incelenmiştir. \u0000Bulgular: HİPEK ile tedavi edilen toplam 29 nüks ileri evre over kanseri hastası dahil edilmiştir. Primer cerrahi sırasında sekiz olguda R0, 20 olguda R1 ve bir hastada R2 rezeksiyon mevcuttur.. R0 rezeksiyon uygulanan hastalarda istatistiksel olarak anlamlı şekilde daha yüksek sağkalım oranı gözlenmiştir (p","PeriodicalId":119624,"journal":{"name":"Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140524455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: The rapidly increasing prevalence of gynecological diseases worldwide emphasizes the need for a combination of effective surgical procedures and other treatments. Therefore, this study was conducted to evaluate the urodynamic changes of laparoscopic and vaginal hysterectomy. Materials and Method: A total of 86 participants who underwent hysterectomy for benign reasons between 2017 and 2021 in a tertiary hospital were selected and divided into two groups. Group I included 43 participants treated with vaginal hysterectomy, while group II included 43 participants treated with laparoscopic hysterectomy. ICIQ-FLUTS questionnaire was used and statistical analysis was performed to determine flow rate, voiding time and other factors in both groups. Results: The results from this study showed that there was no change in the initial sensory context in both groups (p = 3.63). Bladder capacity also did not differ in both groups. However, postoperatively, excessive activity in the detrusor muscle was observed in 8 participants (18.6%) in group I, while it was observed in 2 participants (4.6%) in group II. Similarly, the flow rate and residual volume of urine were within the clinical range in both groups. Conclusion: This study has been effective in providing several implications for improving treatment procedures for patients with gynecological diseases.
{"title":"Cerrahi Yaklaşımın İdrar Yolu Fonksiyonuna Etkisi: Laparoskopik ve Vajinal Histerektomi Sonrası Ürodinamik Değişikliklerin Karşılaştırılması","authors":"Aylin ÖNDER DİRİCAN, Tezcan Sezgi̇n","doi":"10.38136/jgon.1406137","DOIUrl":"https://doi.org/10.38136/jgon.1406137","url":null,"abstract":"Aim: The rapidly increasing prevalence of gynecological diseases worldwide emphasizes the need for a combination of effective surgical procedures and other treatments. Therefore, this study was conducted to evaluate the urodynamic changes of laparoscopic and vaginal hysterectomy. Materials and Method: A total of 86 participants who underwent hysterectomy for benign reasons between 2017 and 2021 in a tertiary hospital were selected and divided into two groups. Group I included 43 participants treated with vaginal hysterectomy, while group II included 43 participants treated with laparoscopic hysterectomy. ICIQ-FLUTS questionnaire was used and statistical analysis was performed to determine flow rate, voiding time and other factors in both groups. Results: The results from this study showed that there was no change in the initial sensory context in both groups (p = 3.63). Bladder capacity also did not differ in both groups. However, postoperatively, excessive activity in the detrusor muscle was observed in 8 participants (18.6%) in group I, while it was observed in 2 participants (4.6%) in group II. Similarly, the flow rate and residual volume of urine were within the clinical range in both groups. Conclusion: This study has been effective in providing several implications for improving treatment procedures for patients with gynecological diseases.","PeriodicalId":119624,"journal":{"name":"Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi","volume":" 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139139993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yüksel Oğuz, Can Ozan Ulusoy, Recep Taha Agaoglu, Kadriye Yakut Yücel, Zehra Yilmaz
Objectives The modified myocardial performance index (Mod‐MPI) is a new technique that is used to assess myocardial function. Gestational Diabetes can affect myocardial function and may lead to change Mod –MPI value. We aimed to evaluate fetal cardiac function with Mod-MPI in pregnant with GDM and compare with healthy pregnant. Material and Methods Totally 60 pregnant; 30 with GDM and 30 without disease were included into this prospective case control study. Demographic characteristics of the study group were recorded. Mod-MPI and obstetric Doppler parameters were calculated for each fetus by an experienced perinatologist. The results of the two groups were compared. Results There was no difference in demographic characteristics terms of age, parity and BMI. The mean Mod-MPI value was found significantly higher in pregnant with GDM when compared with healthy pregnant. The obstetric Doppler parameters were found similar between groups. Conclusion The utility of the Mod‐MPI in GDM pregnant is unclear in literature. Future prospective studies with larger number of cases are needed to to evaluate the utility of the Mod‐MPI as a predictor of cardiac function in fetuses of GDM mothers.
{"title":"The Modified Myocardial Index for Evaluation of Fetal Cardiac Function in Gestational Diabetes Mellitus","authors":"Yüksel Oğuz, Can Ozan Ulusoy, Recep Taha Agaoglu, Kadriye Yakut Yücel, Zehra Yilmaz","doi":"10.38136/jgon.1378081","DOIUrl":"https://doi.org/10.38136/jgon.1378081","url":null,"abstract":"Objectives The modified myocardial performance index (Mod‐MPI) is a new technique that is used to assess myocardial function. Gestational Diabetes can affect myocardial function and may lead to change Mod –MPI value. We aimed to evaluate fetal cardiac function with Mod-MPI in pregnant with GDM and compare with healthy pregnant. Material and Methods Totally 60 pregnant; 30 with GDM and 30 without disease were included into this prospective case control study. Demographic characteristics of the study group were recorded. Mod-MPI and obstetric Doppler parameters were calculated for each fetus by an experienced perinatologist. The results of the two groups were compared. Results There was no difference in demographic characteristics terms of age, parity and BMI. The mean Mod-MPI value was found significantly higher in pregnant with GDM when compared with healthy pregnant. The obstetric Doppler parameters were found similar between groups. Conclusion The utility of the Mod‐MPI in GDM pregnant is unclear in literature. Future prospective studies with larger number of cases are needed to to evaluate the utility of the Mod‐MPI as a predictor of cardiac function in fetuses of GDM mothers.","PeriodicalId":119624,"journal":{"name":"Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi","volume":"3 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139157930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
İ. Aral, Havva Beyaz, S. AYTAÇ ARSLAN, Sedef GÖKHAN AÇIKGÖZ, Y. Tezcan
Fertility is an important component of quality of life and oncological patients should be questioned about their expectations before treatment. Radiotherapy (RT) can adversely affect fertility irreversibly and progressively. Therefore, patients with expectation of fertility should be evaluated before RT and guided for appropriate interventions. Radiotherapy negatively affects fertility in many aspects. Cranial RT disrupts the hypothalamus-pituitary-ovarian (H-P-O) axis, pelvic RT directly affects the ovary and uterus. Because of the long latent period of endocrinopathies caused by cranial RT, these patients should be followed up for a long time. Due to dose-dependent uterine and ovarian toxicities that develop after abdominopelvic RT, patients are at high risk for infertility and pregnancy complications. Uterus and ovaries have different radiosensitivity depending on age. With aging, radiosensitivity of the uterus decreases, while radiosensitivity of the ovaries increase. Although there is no consensus on the threshold doses that can cause RT-related infertility, according to current data, the threshold value for the hypothalamo-pituitary axis is 30 Gy; 25 Gy for young women and 45 Gy for adult women for the uterus; 10 Gy for acute ovarian failure in the ovary and 25 Gy for premature ovarian failure under 35 years of age. There is no significant relationship between parental radiation exposure and inherited genetic disease in their infants.
{"title":"Radiotherapy, Female Fertility and Ootoxicity","authors":"İ. Aral, Havva Beyaz, S. AYTAÇ ARSLAN, Sedef GÖKHAN AÇIKGÖZ, Y. Tezcan","doi":"10.38136/jgon.1327944","DOIUrl":"https://doi.org/10.38136/jgon.1327944","url":null,"abstract":"Fertility is an important component of quality of life and oncological patients should be questioned about their expectations before treatment. Radiotherapy (RT) can adversely affect fertility irreversibly and progressively. Therefore, patients with expectation of fertility should be evaluated before RT and guided for appropriate interventions. Radiotherapy negatively affects fertility in many aspects. Cranial RT disrupts the hypothalamus-pituitary-ovarian (H-P-O) axis, pelvic RT directly affects the ovary and uterus. Because of the long latent period of endocrinopathies caused by cranial RT, these patients should be followed up for a long time. Due to dose-dependent uterine and ovarian toxicities that develop after abdominopelvic RT, patients are at high risk for infertility and pregnancy complications. Uterus and ovaries have different radiosensitivity depending on age. With aging, radiosensitivity of the uterus decreases, while radiosensitivity of the ovaries increase. Although there is no consensus on the threshold doses that can cause RT-related infertility, according to current data, the threshold value for the hypothalamo-pituitary axis is 30 Gy; 25 Gy for young women and 45 Gy for adult women for the uterus; 10 Gy for acute ovarian failure in the ovary and 25 Gy for premature ovarian failure under 35 years of age. There is no significant relationship between parental radiation exposure and inherited genetic disease in their infants.","PeriodicalId":119624,"journal":{"name":"Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139167889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giriş: Erken gebelik kayıpları en yaygın görülen gebelik komplikasyonlarındandır. Etyolojisi tam bilinmemektedir. Artmış koagülabilite tekrarlayan gebelik kayıplarına sebep olmakta ve antikoagülan tedavi nedeni bilinmeyen gebelik kayıplarında canlı doğum oranını artırmaktadır. Mean Platelet Volume (Ortalama trombosit hacmi, MPV) trombosit agregasyonu ve koagülasyon hakkında bilgi verebilmektedir. Bu çalışmada amaç sağlıklı gebelerle abortus imminens tanısı almış gebelerin MPV değerlerinin karşılaştırılmasıdır. Gereç ve Yöntem: Bu retrospektif çalışmaya 64 abortus imminens (AI) tanısı almış ve 49 sağlıklı gebe olmak üzere toplam 113 hasta dahil edildi. İki grubun tam kan sayımı parametreleri karşılaştırıldı. Data analizleri için One-Sample Kolmogorov-Smirnov Test, Independent Samples Test, Mann-Whitney Test kullanıldı. Sonuçlar: AI tanısı almış hastaların MPV değeri kontrol grubuna oranla anlamlı düşük tespit edildi (p:0.004). Htc değeri AI grubunda anlamlı olarak yüksek bulundu (p:0,006). Diğer tam kan sayımı parametreleri açısından iki grup arasında anlamlı bir fark tespit edilmedi. Tartışma: Çalışmamızda MPV değeri AI tanılı hastalarda anlamlı olarak daha düşük bulundu. Literatürde tekrarlayan gebelik kayıpları olan hastalarda MPV değerinin sağlıklı kontrol grubuna oranla daha yüksek bulunduğunu gösteren çalışmalar mevcuttur. MPV’nin etkili olmadığını ifade eden çalışmalar da mevcuttur. Htc ise diğer çalışmalara paralel olarak AI tanısı almış grupta kontrol grubuna oranla daha yüksek tespit edildi.
{"title":"10-12 Hafta Arası Abortus İmminens Tanısı Almış Gebeler ile Sağlıklı Gebelerde Ortalama Trombosit Hacmi Değerlerinin Karşılaştırılması","authors":"Selver Kübra Akkaya, Rahime BEDİR FINDIK, Eyüp Gökhan Turmuş, Burak Elmas, Özlem Moraloğlu Tekin","doi":"10.38136/jgon.857356","DOIUrl":"https://doi.org/10.38136/jgon.857356","url":null,"abstract":"Giriş: Erken gebelik kayıpları en yaygın görülen gebelik komplikasyonlarındandır. Etyolojisi tam bilinmemektedir. Artmış koagülabilite tekrarlayan gebelik kayıplarına sebep olmakta ve antikoagülan tedavi nedeni bilinmeyen gebelik kayıplarında canlı doğum oranını artırmaktadır. Mean Platelet Volume (Ortalama trombosit hacmi, MPV) trombosit agregasyonu ve koagülasyon hakkında bilgi verebilmektedir. Bu çalışmada amaç sağlıklı gebelerle abortus imminens tanısı almış gebelerin MPV değerlerinin karşılaştırılmasıdır. Gereç ve Yöntem: Bu retrospektif çalışmaya 64 abortus imminens (AI) tanısı almış ve 49 sağlıklı gebe olmak üzere toplam 113 hasta dahil edildi. İki grubun tam kan sayımı parametreleri karşılaştırıldı. Data analizleri için One-Sample Kolmogorov-Smirnov Test, Independent Samples Test, Mann-Whitney Test kullanıldı. Sonuçlar: AI tanısı almış hastaların MPV değeri kontrol grubuna oranla anlamlı düşük tespit edildi (p:0.004). Htc değeri AI grubunda anlamlı olarak yüksek bulundu (p:0,006). Diğer tam kan sayımı parametreleri açısından iki grup arasında anlamlı bir fark tespit edilmedi. Tartışma: Çalışmamızda MPV değeri AI tanılı hastalarda anlamlı olarak daha düşük bulundu. Literatürde tekrarlayan gebelik kayıpları olan hastalarda MPV değerinin sağlıklı kontrol grubuna oranla daha yüksek bulunduğunu gösteren çalışmalar mevcuttur. MPV’nin etkili olmadığını ifade eden çalışmalar da mevcuttur. Htc ise diğer çalışmalara paralel olarak AI tanısı almış grupta kontrol grubuna oranla daha yüksek tespit edildi.","PeriodicalId":119624,"journal":{"name":"Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi","volume":"547 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139177233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Betül Akgün Aktaş, Petek Feriha Uzuner, A. Tanaçan, D. Şahın
Aim: The aim of this study was to investigate the pregnancy prognosis of patients taking beta-blockers for the treatment of cardiac arrhythmias. Materials and Method: This study was a retrospective observational study involving 50 pregnant women with cardiac arrhythmias and 55 healthy pregnant women, admitted between January 1, 2020 and January 1, 2022, to Ankara City Hospital. Beta-blockers were classified into three groups: metaprolol, propranolol, and bisoprolol. The use of beta-blockers was examined in two groups: high-dose and low-dose. For pregnancy outcome, birth week, birth weight and birth weight Z-score, the bHCG MoM and PAPP-A MoM, neonatal APGAR score, and neonatal intensive care unit admission rates were determined. Statistical analysis was performed using IBM SPSS Statistics 26.0 (IBM Corp, Armonk, NY, USA). Shapiro-Wilk and Kolmogorov-Smirnov tests were both used to evaluate normality of variables. Groups were compared using the Student t-test and the Mann-Whitney U test. P-values < 0.05 were considered as statistically significant. Results: The patient group taking beta-blockers had a statistically significant earlier delivery week than the group without beta-blocker use (p=0.000). The rate of primary cesarean deliveries was higher in the study group (p=0.007). Birth weight and APGAR score at the fifth minute was significantly lower in the study group, and NICU admission rate was significantly higher (p=0.006, p=0.000 and p=0.000, respectively). Conclusion: Beta-blockers, a first-line therapy for maternal arrhythmias, may affect fetal development and pregnancy outcomes. İt is recommended that these drugs to be administered are meticulously selected for appropriate subgroups, with lowest effective doses
{"title":"Obstetrics and fetal outcomes in pregnant women with beta-blocker treatment in maternal arrhythmia","authors":"Betül Akgün Aktaş, Petek Feriha Uzuner, A. Tanaçan, D. Şahın","doi":"10.38136/jgon.1275121","DOIUrl":"https://doi.org/10.38136/jgon.1275121","url":null,"abstract":"Aim: The aim of this study was to investigate the pregnancy prognosis of patients taking beta-blockers for the treatment of cardiac arrhythmias. Materials and Method: This study was a retrospective observational study involving 50 pregnant women with cardiac arrhythmias and 55 healthy pregnant women, admitted between January 1, 2020 and January 1, 2022, to Ankara City Hospital. Beta-blockers were classified into three groups: metaprolol, propranolol, and bisoprolol. The use of beta-blockers was examined in two groups: high-dose and low-dose. For pregnancy outcome, birth week, birth weight and birth weight Z-score, the bHCG MoM and PAPP-A MoM, neonatal APGAR score, and neonatal intensive care unit admission rates were determined. Statistical analysis was performed using IBM SPSS Statistics 26.0 (IBM Corp, Armonk, NY, USA). Shapiro-Wilk and Kolmogorov-Smirnov tests were both used to evaluate normality of variables. Groups were compared using the Student t-test and the Mann-Whitney U test. P-values < 0.05 were considered as statistically significant. Results: The patient group taking beta-blockers had a statistically significant earlier delivery week than the group without beta-blocker use (p=0.000). The rate of primary cesarean deliveries was higher in the study group (p=0.007). Birth weight and APGAR score at the fifth minute was significantly lower in the study group, and NICU admission rate was significantly higher (p=0.006, p=0.000 and p=0.000, respectively). Conclusion: Beta-blockers, a first-line therapy for maternal arrhythmias, may affect fetal development and pregnancy outcomes. İt is recommended that these drugs to be administered are meticulously selected for appropriate subgroups, with lowest effective doses","PeriodicalId":119624,"journal":{"name":"Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi","volume":"61 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139237204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Erdal Şeker, Mustafa Koçar, Coskun Umi̇t, Hasan Süt, Koray Görkem Saçinti, Gülşah AYNAOĞLU YILDIZ, Esra Özkavukcu, Acar Koç
Objective: Craniorachischisis is a rare and severe variant of neural tube defects (NTDs). It occurs in 0.51 of every 10,000 pregnancies. There is no reported etiology for this fetal abnormality. It frequently coexists with other anomalies and is believed to result from a genetic defect. To our knowledge, this report will be the first reported from a single institution in the literature on craniorachischisis. Material and methods: We present six cases diagnosed with craniorachisis in our clinic in the last 13 years, whose definitive diagnosis was clarified by necroscopy. Results: Craniorachisis is still a vital anomaly because it is a severe anomaly itself and the rate of accompanying other abnormalities is high. Fully elucidating the cause can also be a guide for other. Conclusion: Craniorachischisis can be diagnosed in the first trimester. The vertebral column should especially be examined in patients diagnosed with exencephaly. The heart, extremities, and thoracic-abdomen should be carefully examined when craniorachischisis is diagnosed. The rate of other anomalies accompanying is high. In future research, if the cause of craniorachischisis is understood, it will provide an understanding of the cause of other accompanying this anomaly.
{"title":"Kranioraşizis vakalarının değerlendirilmesi.","authors":"Erdal Şeker, Mustafa Koçar, Coskun Umi̇t, Hasan Süt, Koray Görkem Saçinti, Gülşah AYNAOĞLU YILDIZ, Esra Özkavukcu, Acar Koç","doi":"10.38136/jgon.1141686","DOIUrl":"https://doi.org/10.38136/jgon.1141686","url":null,"abstract":"Objective: Craniorachischisis is a rare and severe variant of neural tube defects (NTDs). It occurs in 0.51 of every 10,000 pregnancies. There is no reported etiology for this fetal abnormality. It frequently coexists with other anomalies and is believed to result from a genetic defect. To our knowledge, this report will be the first reported from a single institution in the literature on craniorachischisis. Material and methods: We present six cases diagnosed with craniorachisis in our clinic in the last 13 years, whose definitive diagnosis was clarified by necroscopy. Results: Craniorachisis is still a vital anomaly because it is a severe anomaly itself and the rate of accompanying other abnormalities is high. Fully elucidating the cause can also be a guide for other. Conclusion: Craniorachischisis can be diagnosed in the first trimester. The vertebral column should especially be examined in patients diagnosed with exencephaly. The heart, extremities, and thoracic-abdomen should be carefully examined when craniorachischisis is diagnosed. The rate of other anomalies accompanying is high. In future research, if the cause of craniorachischisis is understood, it will provide an understanding of the cause of other accompanying this anomaly.","PeriodicalId":119624,"journal":{"name":"Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi","volume":"15 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139237570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Inci Halilzade, Mohammad İbrahim Halilzade, M. Karslı, Ömer Ata, T. Küçüközkan
Aim: Cartilage destruction has been associated with many factors such as overweight, excessive use of joints and forced movements, abrasion due to the aging process, and genetic factors. Obesity is a modifiable risk factor for osteoarthritis. This study aimed to determine the thickness of knee joint cartilage and demonstrate the impact of the pregnancy process on osteoarthritis development during pregnancy. Matherial and Method: Fifty pregnant women aged 15-42 years, were included in this study. The ultrasound image of dominant knee distal femoral cartilage was measured at the 1st and 3rd trimesters in the lateral condyle, intercondylar area, and medial condyle from the strong anechoic area between the bone cortex and the suprapatellar fat pad. Results: We found that the third trimester cartilage measurements for each of the nulliparous and multiparous pregnant women were significantly thinner than the first trimester cartilage measurements (p=0.001, p=0.005, p
{"title":"THE IMPACT OF PREGNANCY ON DISTAL FEMORAL CARTILAGE- A PROSPECTIVE COHORT STUDY","authors":"Inci Halilzade, Mohammad İbrahim Halilzade, M. Karslı, Ömer Ata, T. Küçüközkan","doi":"10.38136/jgon.1392969","DOIUrl":"https://doi.org/10.38136/jgon.1392969","url":null,"abstract":"Aim: Cartilage destruction has been associated with many factors such as overweight, excessive use of joints and forced movements, abrasion due to the aging process, and genetic factors. Obesity is a modifiable risk factor for osteoarthritis. This study aimed to determine the thickness of knee joint cartilage and demonstrate the impact of the pregnancy process on osteoarthritis development during pregnancy. Matherial and Method: Fifty pregnant women aged 15-42 years, were included in this study. The ultrasound image of dominant knee distal femoral cartilage was measured at the 1st and 3rd trimesters in the lateral condyle, intercondylar area, and medial condyle from the strong anechoic area between the bone cortex and the suprapatellar fat pad. Results: We found that the third trimester cartilage measurements for each of the nulliparous and multiparous pregnant women were significantly thinner than the first trimester cartilage measurements (p=0.001, p=0.005, p","PeriodicalId":119624,"journal":{"name":"Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139236855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amaç: Kanser hastalarının pek çok alanda destekleyici bakıma gereksinimi vardır. Çalışmada jinekolojik onkoloji hastalarının destekleyici bakım gereksinimlerinin ve etkileyen faktörlerin belirlenmesi amaçlanmıştır. Gereçler ve Yöntem: Tanımlayıcı-kesitsel tipteki çalışma jinekolojik kanser tanısı almış ve iki hastanenin gündüz ve ayaktan tedavi birimlerine kemoterapi ve/veya radyoterapi için başvuran, gönüllü 195 kadın hasta ile yürütülmüştür. Veriler “Tanıtıcı Bilgi Formu” ve “Destekleyici Bakım Gereksinimleri Ölçeği-Kısa Formu (DBGÖ-KF)” ile toplanmıştır. Bulgular: Jinekolojik onkoloji hastalarının DBGÖ-KF puan ortalaması 77,74±16,14 dür. Özellikle hastaların ruhsal/psikolojik, sağlık hizmeti ve bilgilendirme ve fiziksel/günlük yaşam alanlarında daha fazla destekleyici bakım gereksinimlerinin olduğu ve karşılanmamış olduğu belirlenmiştir. Hastaların yaş, eğitim düzeyi, çalışma durumu, maddi durum algısı, çocuk varlığı, çocuk sayısı, kemoterapi kür sayısı ve tedavi türü değişkenlerinin destekleyici bakım gereksinimleri üzerinde istatistiki yönden anlamlı bir etkinliğin olduğu saptanmıştır (p
{"title":"Supportive Care Needs of Patients With Gynecological Oncology And Affecting Factors","authors":"İzel Danişkan, Dilek Bi̇lgi̇ç, H. Okumuş","doi":"10.38136/jgon.1243416","DOIUrl":"https://doi.org/10.38136/jgon.1243416","url":null,"abstract":"Amaç: Kanser hastalarının pek çok alanda destekleyici bakıma gereksinimi vardır. Çalışmada jinekolojik onkoloji hastalarının destekleyici bakım gereksinimlerinin ve etkileyen faktörlerin belirlenmesi amaçlanmıştır. Gereçler ve Yöntem: Tanımlayıcı-kesitsel tipteki çalışma jinekolojik kanser tanısı almış ve iki hastanenin gündüz ve ayaktan tedavi birimlerine kemoterapi ve/veya radyoterapi için başvuran, gönüllü 195 kadın hasta ile yürütülmüştür. Veriler “Tanıtıcı Bilgi Formu” ve “Destekleyici Bakım Gereksinimleri Ölçeği-Kısa Formu (DBGÖ-KF)” ile toplanmıştır. Bulgular: Jinekolojik onkoloji hastalarının DBGÖ-KF puan ortalaması 77,74±16,14 dür. Özellikle hastaların ruhsal/psikolojik, sağlık hizmeti ve bilgilendirme ve fiziksel/günlük yaşam alanlarında daha fazla destekleyici bakım gereksinimlerinin olduğu ve karşılanmamış olduğu belirlenmiştir. Hastaların yaş, eğitim düzeyi, çalışma durumu, maddi durum algısı, çocuk varlığı, çocuk sayısı, kemoterapi kür sayısı ve tedavi türü değişkenlerinin destekleyici bakım gereksinimleri üzerinde istatistiki yönden anlamlı bir etkinliğin olduğu saptanmıştır (p","PeriodicalId":119624,"journal":{"name":"Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi","volume":"25 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139280496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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