European Journal of Dermatology最新文献

Autoimmune diseases have been linked to keloids in observational studies. Yet, the causality underlying this association remains ambiguous. To investigate the causal effects of selected autoimmune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), type 1 diabetes (T1D), inflammatory bowel disease (IBD), Crohn's disease (CD), and ulcerative colitis (UC), on keloids. We conducted a bidirectional two-sample Mendelian randomization (MR) analysis utilizing publicly released genome-wide association studies summary statistics. The inverse-variance weighted (IVW) method served as the primary analysis tool, supplemented by other methods such as weighted median, weighted mode, and MR Egger regression. Outliers, heterogeneity, and pleiotropy were assessed using the MR-PRESSO outlier test, Cochran's Q test, and MR-Egger regression, respectively. The IVW analysis revealed that genetically determined autoimmune diseases do not causally effect keloids (RA: OR=0.95, 95% CI: 0.89-1.00, p=0.07; SLE: OR=0.98, 95% CI: 0.93-1.02, p=0.34; IBD: OR=1.01, 95% CI: 0.90-1.03, p=0.27; CD: OR=1.02, 95% CI: 0.96-1.09, p=0.56; UC: OR=0.97, 95% CI: 0.90-1.04, p=0.34; T1D: OR=0.98, 95% CI: 0.95-1.01, p=0.27). Reverse IVW MR analysis showed no significant causal effect of keloids on autoimmune diseases. The results from MR-Egger regression, weighted median, and weighted mode methods were consistent with those obtained from the IVW method, and sensitivity analysis suggested that horizontal pleiotropy was unlikely to distort the causal estimates. Our MR analysis does not provide strong evidence supporting causal associations between autoimmune diseases and keloids in the European population.

Hidradenitis suppurativa has emerged from therapeutic obscurity only in the last few years. Initially, the purulent and infectious nature of the lesions naturally lead to first-line treatment with antibiotics, some of which are indeed highly effective, particularly for moderate forms, or when used to overcome a highly inflammatory acute flare. Subsequent advances in physiopathology have emphasised the significant value of immunomodulatory therapies, mainly via the blockade of the TNF-α and IL-17 cytokine pathways. Modulation of these nonspecific immune and inflammatory signalling pathways is thus becoming increasingly important in numerous on-going therapeutic trials: JAK pathway and complement inhibition, IL-1 blockade, and even inhibition of B-lymphocyte activation pathways. In this article we detail the currently available data and drugs, and their indications in relation to disease stage, while being constantly aware that presently optimal results require multidisciplinary collaboration and often the use of combination therapies.

Photoelectric therapies (or non-invasive energy-based device treatment), especially picosecond lasers and intense pulsed light (IPL) treatments, are widely used to manage various cutaneous conditions, including pigmentation, inflammation, and signs of aging. However, these treatments can also impair the integrity of the skin barrier, making post-treatment repair of skin barrier function essential to maintain perioperative curative effects. To evaluate the safety and efficacy of Eucerin® UltraSensitive Soothing Care Gel (GEL) and co-use of GEL and Eucerin® UltraSensitive Repair Intensive Source Serum (CO-USE) during the perioperative procedure. This study was designed with a four-week follow-up period, in which the first two weeks represented a pre-treatment phase. Self-assessment, clinical evaluation, and non-invasive skin testing were used at each visit after treatments to determine the efficacy of the two products. Compared to the placebo (PBO) group, both the GEL and CO-USE groups exhibited a significantly greater reduction in transepidermal water loss (TEWL) and a notable increase in stratum corneum hydration (SCH) 24 hours post treatment. Regarding facial redness, there was a significantly greater decrease in the GEL and CO-USE groups compared to the PBO group at all follow-up time points on the picosecond laser side. Moreover, the CO-USE group showed superior efficacy in alleviating skin sensitivity symptoms following the interventions. Both products were well tolerated and exhibited favourable safety profiles. Both commercially available skincare products tested in the present study were found to be clinically effective in inhibiting laser-induced skin barrier damage, and reducing skin redness and skin sensitivity.