European journal of medicinal plants最新文献

{"title":"Top Edible Wild Plants of Eastern Mediterranean Region. Part III: Antidiabetic Activity","authors":"Abdullatif Azab","doi":"10.9734/ejmp/2023/v34i91160","DOIUrl":"https://doi.org/10.9734/ejmp/2023/v34i91160","url":null,"abstract":"In the first two parts of this series of review articles, we presented the anticancer and anti-inflammatory activities of the most important wild edible plants of eastern Mediterranean region, which we named as the “Deca-plants” (D-P). In this review article, we will present the antidiabetic activities of these very important plants. Comparing with anticancer and anti-inflammatory activities, the overall antidiabetic activity of the D-P is moderate, but there are clear differences between the ten species. Based on this fact and on the knowledge that the D-P contain several natural products with proven antidiabetic activity, in the discussion section (4), possible future research directions will be indicated. In addition to presenting the reported antidiabetic activity of the plants, some important statistical facts about diabetes will be presented, as well as ethnomedicinal use of these plants for diabetes treatment, in the reviewed region. For the purpose of comparison and comprehensiveness, in the last part of this article, four Non-Deca-Plants with reported antidiabetic activity will be shortly reviewed, when the criteria of selection are wild and edible.","PeriodicalId":11969,"journal":{"name":"European journal of medicinal plants","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135883848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacognostic Evaluation of Simarouba glauca DC Bark","authors":"Ramachandra Mohan Rao Pandhari, Tarikere Chandrashekharappa Taranath","doi":"10.9734/ejmp/2023/v34i91158","DOIUrl":"https://doi.org/10.9734/ejmp/2023/v34i91158","url":null,"abstract":"Simarouba glauca DC also known as ‘Dysentery Bark’ is an important ethnomedicinal plant native to Tropical America. Later introduced India as “Lakshmi-Taru.” Bark is a potent anti-microbial, anti-diabetic, anti-cancer, and hemolytic drug. This study presents a pharmacognostic evaluation of Simarouba glauca DC bark, mainly shedding light on its macroscopic and microscopic characteristics. Identification, authentication, macroscopic observation, and TLS, RLS and Powder microscopical examinations have been carried out.
 The macroscopic examination of the bark revealed distinctive features, including a rough, fissured surface, and a yellowish-brown colour. Microscopic analysis showcased the presence of a thick periderm with small flakes raised above the periderm surface. The outer part of phellem is crushed and the inner portion is modified into a thick cylinder of sclereids. The Phelloderm becomes thick walled and dark coloured and stores calcium oxalate crystals. Large prismatic calcium oxalate crystals located in uniseriate vertical row within thin parenchyma cells. TLS revealed that the phloem fibers in dense compact bundles. The fibers being highly thick walled and lignified with narrow cell lumen. The rays are 250-280 µm in height and 40-60µm. RLS showed the rays are rentered heterocellular. Parenchyma cells and fibers are vertical position at right angles to the rays. Bark powder microscopy exhibited the presence of narrow and wide fibers, fiber-sclereids, long sieve elements, thick brachy sclereids, and large quantity of quadrangular, rectangular, and polygonal Calcium oxalate crystals. These observations provide valuable diagnostic tools for the authentication and quality control of S. glauca DC bark.
 The pharmacognostic characterization presented in this study serves as a foundation for further research and development of S. glauca DC bark-based herbal medicines and pharmaceutical formulations. The insights provided in this article contribute to the understanding and utilization of this valuable botanical resource, fostering a bridge between traditional knowledge and contemporary scientific approaches in pharmacognosy.","PeriodicalId":11969,"journal":{"name":"European journal of medicinal plants","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135884947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventive and Healing Effects of the Total Aqueous Extract of the Trunk Bark of Zanthoxylum gilletii (De Wild.) P. G. Waterman (Rutaceae) on Gastric Acid Reflux and Non-reflux Induced Esophagitis in Rats","authors":"Oussou N’Guessan Jean-Baptistea, Goze Nomane Bernarda, Ehilé Ehilé Hervéa, Grahouan Pizito Stéphanea, Kouakou Kouakou Léandrea, Yapo Angoué Paula","doi":"10.9734/ejmp/2023/v34i81153","DOIUrl":"https://doi.org/10.9734/ejmp/2023/v34i81153","url":null,"abstract":"Zanthozylum gilletii is a medicinal plant well known for its richness in phytochemicals and its use in Côte d’Ivoire in the traditional treatment of burns in esophagus. However, its bioactive anti-reflux and non-reflux oesophagitis potential has not yet been scientifically proven. This work aims at evaluating the preventive and curative anti-esophagitis potential of a total aqueous extract of Z. gilletii trunk bark (TAEZg) in rats. Thirty-six rats were subjected to 24 hours fast and divided into six groups of six rats each were used for each model of esophagitis induction, in particular the preventive model (acute, chronic, chronic exposure to naproxen followed by forced swimming test) and the healing model. Rats received as a pretreatment (preventive model) and treatment (healing model), TAEZg at 125, 250 and 500 mg / kg of body weight (b.w.) as well as omeprazole (preventive model) and misoprostol (healing model) at 30 and 0.012 mg / kg b.w respectively. As for the control groups, they received distilled water at 1 mL/ 100 g b.w. The animals were sacrificed by over dose of ether and then the ulcer macroscopic parameters (ulceration surface, ulceration index, scores and inhibition percentages) and gastric secretion parameters (gastric volume, gastric acidity and gastric pH) were assessed. Biochemical parameters such as total proteins and some oxidative stress parameters (Malondialdehyde (MDA) and catalase (CAT)) were assessed. The results showed that pretreatment and treatment of rats with TAEZg at doses ranging from 125 to 500 mg / kg b.w significantly (P <0.001) and dose dependently reduced ulceration surface, ulceration index, gastric volume, gastric acidity, score and significantly (P <0.001) increase pH and inhibition percentage compared to control group 2. The inhibition percentages such as 93.71; 95.89; 91.03 and 98.20 % were recorded at 500 mg / kg in preventive model (acute, chronic and chronic exposure to naproxen followed by forced swimming test) and healing model respectively. Biochemical analysis showed a significant (P <0.001) increase in total protein, CAT levels and a significant decrease (P <0.001) in MDA level of the treated groups compared to the control group 2. In conclusion, TAEZg possessed a real preventive and healing anti-esophagitis effects in rats.","PeriodicalId":11969,"journal":{"name":"European journal of medicinal plants","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136183503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimation of Oleanolic Acid by HPTLC and HPLC Methods in Successive Leaf Extracts of Leucas aspera and Tridax procumbens and their In vitro Anti-Inflammatory Activity","authors":"None Jayaprakasam R., None Abinaya R., None Gandhimathi M., None Ravi T. K.","doi":"10.9734/ejmp/2023/v34i81157","DOIUrl":"https://doi.org/10.9734/ejmp/2023/v34i81157","url":null,"abstract":"Aims: The study was started with the goal of quantifying the oleanolic acid from consecutive leaf extracts of Leucas aspera and Tridax procumbens using a marker oleanolic acid by utilizing HPTLC and HPLC techniques, as well as to perform an evaluation of their antiinflammatory activity.&#x0D; Place and Duration of Study: The study was carried out between October 2022 and June 2023 in the Department of Pharmaceutical Analysis and Pharmacognosy, Sri Ramakrishna Institute of Paramedical Sciences, College of Pharmacy, Coimbatore-44, Tamil nadu, India.&#x0D; Methodology: The extraction of leaves is done using successive extractions by Continuous hot percolation method using soxhlet extractor. Petroleum ether, ethyl acetate and methanol fractions for which the phytochemical analysis were conducted. Standardization of oleanolic acid was performed by using HPTLC and HPLC techniques. Quantification of oleanolic acid in the two plants sequential leaf extracts were done. In vitro study of antiinflammatory activity was performed by Xanthine oxidase inhibitory activity in the ethyl acetate fraction.&#x0D; Results: Alkaloids, glycosides, terpenoids, steroids, flavonoids, saponins, carbohydrates, and proteins were all found in the two plant extracts by using phytochemical screening. In HPTLC method, petroleum ether, ethyl acetate and methanol leaf extracts of Leucas aspera and Tridax procumbens were developed in suitable mobile phase of toluene: ethyl acetate: formic acid (7:3:0.2%v/v/v) followed by derivatizing with anisaldehyde sulphuric acid derivatizing agent and scanned under 530nm. HPLC of standard marker and successive leaf extracts of Leucas aspera and Tridax procumbens were carried out using methanol: 25mM phosphate buffer (pH-3) in the ratio of 90:10% v/v at flow rate of 1ml/min and chromatograms were recorded at 202nm. Xanthine oxidase inhibitory activity of combined leaf extracts of ethyl acetate showed IC50 value of 0.026μg/ml. &#x0D; Conclusion: Standardization of oleanolic acid was conducted by HPTLC and HPLC methods and linearity were found to be 0.9964 and 0.9998 respectively. Quantification of oleanolic acid in successive leaf extracts of the two plants were conducted. In vitro study using xanthine oxidase inhibitory activity showed that combined extracts of ethyl acetate fractions exhibited better antiinflammatory property than the individual extracts of the selected plants.","PeriodicalId":11969,"journal":{"name":"European journal of medicinal plants","volume":"152 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135295971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Top Edible Wild Plants of Eastern Mediterranean Region Part II: Anti-inflammatory Activity","authors":"Abdullatif Azab","doi":"10.9734/ejmp/2023/v34i91155","DOIUrl":"https://doi.org/10.9734/ejmp/2023/v34i91155","url":null,"abstract":"In the first part of this series of review articles, we presented the anticancer activities of the most important wild edible plants of eastern Mediterranean region, which we named as the “Deca-plants” (D-P). In this review article, we will present the anti-inflammatory activities of these very important plants. After a brief introduction, anti-inflammatory activities of the D-P will be introduced in both traditional medicine of the peoples of this region, and in published scientific literature. Methods of use will be presented in the first part, and methods of testing and results, for modern research. In both cases, some of the D-P have notable anti-inflammatory activities. In the extensive discussion section of this article, a major focus will be presented for anti-inflammatory activities of natural products contained in these plants, and some comparisons will be made with other plants. At this point, it is worth mentioning that the D-P have notably different number of anti-inflammatory activity reports, where on the top of them Foeniculum vulgare can be found. Contrary to that and to the best of our knowledge, Cyclamen persicum was not published for anti-inflammatory activity, even though some of its secondary metabolites are very well known for having this activity. Typical search methods were used for finding relevant literature. Finally, the conclusions of this article will be accompanied with recommendations for future research.","PeriodicalId":11969,"journal":{"name":"European journal of medicinal plants","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135245717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analyses of the Antimicrobial, Antioxidant, and Phytochemical Composition of Two Species of Moringa in Ghana","authors":"Salifu Faisal, Christopher Larbie, John Mensah, Afua Kobi Ampem Genfi, Abena Amponsaa Brobbey","doi":"10.9734/ejmp/2023/v34i91156","DOIUrl":"https://doi.org/10.9734/ejmp/2023/v34i91156","url":null,"abstract":"Moringa oleifera and M. stenopetala have been used to cure a variety of ailments in around the world. The phytochemical profile, antioxidant and antibacterial activity of the leaves, roots and stem bark were investigated. Elements were analysed and bioactive components were characterised using FTIR and GC/MS methods. Total phenolics, tannins, and flavonoids were assessed while radical scavenging activity was evaluated by the DPPH assay. Some organic compounds like phenols and aromatics were present, along with iron, zinc, and copper. The total phenolic and tannin concentrations varied from 98.73 to 255.57 mg GAE/100 g, and from 29.45 to 243.27 mg GAE/100 g, respectively. The total flavonoid content ranged from 717.90 to 73052.62 g QE/100 g. The methanolic extract of M. oleifera roots had the best DPPH scavenging efficacy. The extracts showed some antibacterial and antifungal activity. Therefore, M. oleifera and M. stenopetala contain phytochemicals and may be beneficial to health.","PeriodicalId":11969,"journal":{"name":"European journal of medicinal plants","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135199218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of Pharmacological Profile of Chloroform Leaf Extract of Ludwigia perennis - A Wetland Plant","authors":"None Syamkumar T. S., Geethalakshmi. S, Anu Augustine","doi":"10.9734/ejmp/2023/v34i81154","DOIUrl":"https://doi.org/10.9734/ejmp/2023/v34i81154","url":null,"abstract":"Aim: The main objective of this study was to find out various therapeutic properties of chloroform leaf extract of the wetland plant Ludwigia perennis.&#x0D; Place and Duration of Study: Department of Biotechnology, Sree Narayana Guru College, Coimbatore, Tamilnadu, Scigen Research and Innovation in Thanjavur, Tamil Nadu; and the Sri Lakshmi Narayana Institute of Medical Sciences in Osudu, Pondicherry between April 2023 and August 2023.&#x0D; Methodology: Chloroform leaf extract of Ludwigia perennis was employed for evaluating the antioxidant, antidiabetic, anti-nutritional, anticancer, anti-inflammatory, and antipyretic properties, respectively.&#x0D; Results: The DPPH assay found that the IC50 for the leaf extract was 48.78µg/mL, while the IC50 for the standard was 49.74µg/mL. The IC50 for the phosphomolybdenum test was 32.31µg/mL for the leaf extract and 33.73µg/mL for the standard. The IC50 values for the hydroxyl radical scavenging experiment were 55.6µg/mL for the standard and 47.54µg/mL for the leaf extract. The IC50 of the standard in the α-amylase inhibitory assay is 394.48µg/mL, and the extract's IC50 is 330.38µg/mL, respectively. The IC50 of the standard in the α-glucosidase inhibitory assay was 394.06µg/mL, and the extract's IC50 was 335.45µg/mL, respectively. Antinutrient content such as alkaloids was 21.4%, oxalate was 6.6%, phytate was 4.18%, and saponin was 30%, respectively. The IC50 of HeLa cells treated with leaf extract was 180µg/mL. After 4hours of treatment with chloroform leaf extract, the inhibition was 51.75% when 50mg/kg was used and 58.74% when 250mg/kg was used. Here, the inhibitory percentage of indomethacin is 59.45%. This means that the leaf extract has anti-inflammatory activity. Chloroform leaf extracts produced significant antipyretic effects in 250 and 500mg/kg doses.&#x0D; Conclusion: Therefore, the chloroform leaf extract of Ludwigia perennis has shown to have anti-oxidant, anti-diabetic, anti-nutrient, anti-cancer, anti-inflammatory, and anti-pyretic activities. These evidences suggest the plant is a potential source for developing new drugs.","PeriodicalId":11969,"journal":{"name":"European journal of medicinal plants","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135247290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Diversity of Coffee Genotypes Using Simple Sequence Repeat (SSR) Markers","authors":"A. F. Adepoju, I. O. Sobowale, O. Adenuga","doi":"10.9734/ejmp/2023/v34i81151","DOIUrl":"https://doi.org/10.9734/ejmp/2023/v34i81151","url":null,"abstract":"Coffee plays an important role in the global economy, human health and society. It is one of the major cash crops constituting the backbone of the Nigerian economy before the emergence and re-emergence of petroleum oil. Molecular markers are reliable and valuable tool for analyzing polymorphism, screening and selection of desirable genotypes in breeding programs. The study aimed at determining the genetic diversity among coffee genotypes. Fifty genotypes of coffee (Coffea spp) collected from Cocoa Research Institute of Nigeria (CRIN) germplasm were assessed using 12 simple sequence repeat (SSR) markers. The findings revealed that polymorphic information content (PIC) ranged between 0.311 and 0.882 with an average of 0.545. The gene diversity (0.602) was high and the Unweighted Pair Group Method of Analysis using arithmetic averages (UPGMA) dendrogram grouped the genotypes into four major clusters with subclusters. The results revealed high levels of polymorphism indicating genetic diversity and confirm uniqueness among the coffee genotypes.","PeriodicalId":11969,"journal":{"name":"European journal of medicinal plants","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84278256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shoot Culture of Ocimum sp. and Its Phytochemical Profile","authors":"R. Mastuti, A. Munawarti, D. Siswanto","doi":"10.9734/ejmp/2023/v34i81150","DOIUrl":"https://doi.org/10.9734/ejmp/2023/v34i81150","url":null,"abstract":"The success of the in vitro culture technique is influenced by many factors, including the type of explants, culture medium and exogenous plant growth regulators (PGR). These factors greatly influence the speed and effectiveness of plant regeneration as well as the profile of the phytochemical compounds produced. Therefore, this study aims to determine the effect of the PGR combination on the growth response of in vitro node explants as well as the phytochemical profiles of Ocimum sp. Node explants obtained from 2 weeks old in vitro seedlings were cultured on MS medium with the addition of PGR, namely BAP and Kinetin (0.2 and 5 mg/l) combined with NAA (0.1 and 0.2 mg/l) and synthetic cytokinins alone namely Thidiazuron (TDZ) (1, 3, and 5 mg/l). The growth response of the explants and the potential for regeneration were observed for 8 weeks of culture. Effects of adding activated charcoal (AC) to root media were observed on growth of plantlets aged 2 weeks. Phytochemical profile of In vitro shoot was analyzed using GC-MS and LC-MS to be compared with its profile in in vitro callus tissue. The results showed that MS medium with the addition of a combination of cytokinin and auxin was able to induce shoot regeneration in node explants of Ocimum sp. in vitro. The Kinetin/NAA combination produced better shoot height growth, while the BAP/NAA combination produced a higher leaves number. Thidiazuron at all concentrations was able to induce shoots that were more likely to form rosettes. The addition of AC to the rooting medium did not have a positive effect on the response of shoot and plantlet growth. Chromatographic screening showed different profiles of secondary compounds in the callus and shoot tissues of Ocimum sp. in vitro. Callus composed of actively dividing cells do not produce some of the secondary compounds as produced by in vitro shoots. This shows the difference in the potential of cells or tissues in synthesizing secondary metabolites.","PeriodicalId":11969,"journal":{"name":"European journal of medicinal plants","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87033650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Effect of the Fermented Seeds of Parkia biglobosa on Rabbits Oryctolagus cuniculus","authors":"Komlavi Mawuto Benjamin Apedjinou, Sabrina Sanvee, Komlan M Dossou-Yovo, Mindédé Assih, Essotolom Badjabaissi, Aboudoulatif Diallo, B. Bakoma","doi":"10.9734/ejmp/2023/v34i71149","DOIUrl":"https://doi.org/10.9734/ejmp/2023/v34i71149","url":null,"abstract":"Background and Objectives: Fermented seeds of Parkia biglobosa or “African mustard” are widely consumed in Togo. These fermented seeds are known to have a protective effect against the occurrence of cardiovascular diseases. The objective of the present study is to evaluate the effect of the decoction of fermented seeds on cardiovascular system. \u0000Methods: The fermented seeds have been subjected to physicochemical tests. A decoction was prepared and underwent qualitative and quantitative phytochemical tests. The decoction was also administered intravenously to rabbits at cumulative doses (17.5 mg / kg; 35 mg / kg; 70 mg / kg and 140 mg / kg) to assess the effect of Parkia biglobosa fermented seeds on the cardiovascular system. Parameters such as blood pressure, heart rate, and electrocardiogram (ECG) were then recorded. \u0000Results: The fermented seeds had a water content of 8.1 ± 0.2%, the total ash content was 21 ± 0.4% and the content of ash insoluble in hydrochloric acid of 2.3 ± 0.1%. The extract contained alkaloids, cardiac glycosides (with a content of 13.9 ± 0.2 µg equivalent of Digoxin / mg of extract) and saponins. The decoction causes a dose-dependent hypotension and bradycardia at 140mg / kg. The ECG shows a decrease of the amplitude of QRS complex at doses of 70 mg / kg and 140 mg / kg. \u0000Conclusion: The decoction has a dose-dependent hypotensive effect probably linked to its cardiotonic glycosides.","PeriodicalId":11969,"journal":{"name":"European journal of medicinal plants","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84150470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}