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Morphology of carotid sinus wall under the influence of monosodium glutamate and following its withdrawal: an experimental study 谷氨酸钠作用下及停药后颈动脉窦壁形态的实验研究
IF 0.3 Q4 ANATOMY & MORPHOLOGY Pub Date : 2023-07-01 DOI: 10.52083/ebsh2762
O. Sodomora, L. Mateshuk-Vatseba, T. Harapko, Vasyl Kovalyhyn, M. Kolishetska
The aim of this experimental study was to evaluate micro- and ultrastructural changes of the carotid sinus wall during oral consumption of low doses of monosodium glutamate (MG) and following its withdrawal. Adult male albino rats (n=39) were enrolled into the study. Carotid sinus wall morphology was assessed by light and electron microscopy at the end of week 4 and week 8 of MG oral consumption, as well as 2 weeks after its withdrawal; the results were compared with the control group. After 8 weeks of MG consumption, the wall of the carotid sinus was disorganized, endothelial layer of intima deformed, often without clear margins, the media edematous and dissected with thickened elastic membranes, and the cells of the vascular wall were showing signs of apoptosis while extra fat was present in the adventitia. Upon discontinuation of MG after 4 weeks of its consumption, the structural organization of carotid sinus wall was partially preserved, whereas no compensatory processes were registered after 8 weeks of MG administration followed by 2 weeklong withdrawal. Therefore, 8-week-long lowdose MG consumption resulted in pronounced changes of the micro- and ultra-structure of the carotid sinus wall of albino rats. Discontinuation of MG following 4 weeks of its administration partially improved the morphologic characteristics of the carotid sinus wall within 2 weeks. Withdrawal of MG after 8 weeks of its administration did not result in any improvement of the micro- and ultra- structure
本实验研究的目的是评估口服低剂量谷氨酸钠(MG)期间和停药后颈动脉窦壁的超微结构变化。选取成年雄性白化大鼠39只。在口服MG的第4周和第8周结束时以及停药后2周,通过光镜和电镜观察颈动脉窦壁形态;结果与对照组进行比较。MG消耗8周后,颈动脉窦壁组织紊乱,内膜内皮层变形,常无明显边缘,中膜水肿剥离,弹性膜增厚,血管壁细胞凋亡,外膜脂肪增多。服用MG 4周后停药,颈动脉窦壁结构组织部分保留,而服用MG 8周后停药2周后未见代偿过程。因此,持续8周的低剂量MG使白化大鼠颈动脉窦壁超微结构发生明显变化。MG在给药4周后停用,在2周内部分改善了颈动脉窦壁的形态学特征。MG在给药8周后停药并没有导致超微结构的任何改善
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引用次数: 0
The clinical and operative impact of the hexafurcation of the celiac trunk - Report of an extremely rare case 腹腔干六岔的临床及手术影响-一例极为罕见的病例报告
IF 0.3 Q4 ANATOMY & MORPHOLOGY Pub Date : 2023-07-01 DOI: 10.52083/vqme8067
Athina Anagnou, Alexandra Pentheroudaki, E. Lolis
The celiac trunk is a main splanchnic artery that supplies the intra-abdominal organs of the upper gastrointestinal system. Anatomic variations of the celiac trunk are encountered in 10% of the population, but can pose challenges to many surgical and interventional procedures. We present here a case of hexafurcation of the celiac trunk discovered preoperatively after image staging for gastric cancer. The branches of the celiac trunk were: left and right inferior phrenic artery, arc of Buhler along with the common pattern of common hepatic, left gastric and splenic artery. The highlight of the case is the rarity of this specific pattern, which is seen in less than 1% of the population, and also the presence of an anastomotic path, the arc of Bühler, as a branch of the celiac trunk. It is evident that the variations of the celiac trunk play a major role in operations of the upper abdomen, radiological interventional procedures and other uncommon cases. Thus, the surgeon must be aware of these variations and their frequency to avoid complications. Also, any physician should report any variation discovered, accidentally or not, to help the literature to be updated. Key words: Computed tomography – Arc of Bühler – Inferior phrenic arteries variations – Celiac trunk variations – Celiac trunk hexafurcation
腹腔干是主要的内脏动脉,供应上消化道系统的腹腔内器官。10%的人会遇到腹腔干的解剖变异,但这给许多外科和介入性手术带来了挑战。我们在此报告一例在胃癌影像分期后术前发现的腹腔干六岔。腹腔干的分支有:左、右膈下动脉、Buhler弧伴肝总动脉、左胃动脉和脾动脉的共同模式。该病例的重点是这种特殊模式的罕见性,在不到1%的人群中可见,并且存在吻合路径,b hler弧线,作为腹腔干的分支。显然,腹腔干的变异在上腹部手术、放射介入手术和其他罕见病例中起主要作用。因此,外科医生必须了解这些变异及其发生的频率,以避免并发症。此外,任何医生都应报告发现的任何变异,无论是否偶然,以帮助文献更新。关键词:计算机断层扫描-膈下动脉弧-腹腔干变异-腹腔干六分叉
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引用次数: 0
Long-term supplementation with young coconut juice help prevent bone loss of orchidectomized rats by increasing connectivity density, percentage bone volume and osteoblast-/osteocyte-(ERα-/ ERβ-) immunoreactive cells of the L5 vertebra and femur 长期补充椰汁可以通过增加L5椎体和股骨的连接密度、骨体积百分比和成骨细胞/骨细胞(ERα-/ ERβ-)免疫反应细胞来预防兰花切除大鼠的骨质流失
IF 0.3 Q4 ANATOMY & MORPHOLOGY Pub Date : 2023-07-01 DOI: 10.52083/cjwj5539
Asma Asae, A. Hutapea, Jirawat Saetan, N. Radenahmad
Adult male rats were orchidectomized (ORX) and treated with 17β-estradiol or young coconut juice (YCJ) for ten weeks. Their femur and L5 vertebra were dissected, and the percentage of bone volume was measured using a Micro-CT scan. Immunohistochemistry was used to detect ERα and ERβ to determine if the osteoporotic protective effects of YCJ were due to the attachment of the YCJ active components(s) to estrogen receptors. It was found that both ERα and ERβ were found in osteocytes and osteoblasts, but not osteoclasts. Compared to normal rats, the percentage of bone volume and number of osteoblast- and osteocyte- reactive cells of both femur and L5 were significantly reduced in ORX rats. Those numbers in the ORX rats were restored to normal by injecting estradiol benzoate or by feeding YCJ to the rats, which was not dose-related. Significant correlations were detected between osteoblast-/osteocyte- (ERα-/ERβ)-reactive cells vs. serum E2 level. The optimal dose of this study was 10 mL/kg BW/ day for ERα-of both osteoblasts and osteocytes and 40 mL/kg BW/day for ERβ-of both osteoblasts and osteocytes. The results suggest that YCJ may be as efficient as estradiol benzoate in attenuating osteoporosis, probably by being a selective estrogen receptor moderator.
取成年雄性大鼠去兰科(ORX),用17β-雌二醇或幼椰子汁(YCJ)治疗10周。解剖股骨和L5椎体,使用Micro-CT扫描测量骨体积百分比。采用免疫组化法检测ERα和ERβ,以确定YCJ的骨质疏松保护作用是否与YCJ活性成分附着于雌激素受体有关。在成骨细胞和骨细胞中均可见ERα和ERβ,而破骨细胞中不可见ERα和ERβ。与正常大鼠相比,ORX大鼠股骨和L5骨体积百分比、成骨细胞和骨细胞反应细胞数量均显著减少。通过注射苯甲酸雌二醇或喂食YCJ, ORX大鼠的这些数字恢复正常,与剂量无关。成骨细胞/骨细胞(ERα-/ERβ)反应细胞与血清E2水平显著相关。成骨细胞和骨细胞er α-的最佳剂量为10 mL/kg体重/天,成骨细胞和骨细胞er β-的最佳剂量为40 mL/kg体重/天。结果表明,YCJ可能与雌二醇苯甲酸酯一样有效地减轻骨质疏松症,可能是一种选择性雌激素受体调节剂。
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引用次数: 0
Analysis of the use of human remains as teaching materials in higher education: examining differing opinions between population subgroups 在高等教育中使用人类遗骸作为教材的分析:检查人口亚群之间的不同意见
IF 0.3 Q4 ANATOMY & MORPHOLOGY Pub Date : 2023-07-01 DOI: 10.52083/ewhy1593
Georgina A Goodison, Christopher Aris
Human components have been used as teaching resources for centuries. This study aimed to investigate the ethics and practicality surrounding this resource by analysing the opinions of students and professionals with exposure to human remains. Three questions were posed relating to the use of synthetic cadavers, the use of replicated bones, and the overall opinion regarding the ethics of using human material in teaching. These questions were disseminated through a survey aimed at students and professionals working with/studying using human remains in the UK, with 477 respondents. Kruskal-Wallis, Jonckheere Terpstra and Mann-Whitney U tests were used to identify any differences within the participants according to age and gender. Overall, all groups lent towards supporting the use of human remains in teaching. However, significant differences were noted between gender groupings and age categories, in particular between the 21-40 and 61+ age categories regarding the use of cadavers in teaching, and between male and female groups regarding the use of synthetic cadavers and replica bone. Even though multiple differences were noted, there was a consensus that use of human remains in teaching is ethical. The differences related to the degree to which materials should be used across different fields, with medical students and professionals believing that they should have sole access to real materials, whilst both archaeology and heritage professionals and non-professionals believed that all subjects should have access if it will help with students’ education.
几个世纪以来,人体成分一直被用作教学资源。本研究旨在通过分析接触人类遗骸的学生和专业人员的意见,调查这一资源的伦理和实用性。提出了三个问题,涉及使用合成尸体,使用复制骨骼,以及关于在教学中使用人类材料的道德规范的总体意见。这些问题是通过一项针对英国从事人类遗骸工作/研究的学生和专业人士的调查传播的,共有477名受访者。使用Kruskal-Wallis, Jonckheere Terpstra和Mann-Whitney U测试来确定参与者根据年龄和性别的差异。总的来说,所有团体都支持在教学中使用人类遗骸。然而,性别分组和年龄类别之间存在显著差异,特别是在21-40岁和61岁以上年龄组之间,在使用尸体进行教学方面,以及在使用合成尸体和复制骨方面,男性和女性组之间存在显著差异。尽管存在诸多差异,但人们一致认为,在教学中使用人体遗骸是合乎道德的。这些差异与材料在不同领域的使用程度有关,医科学生和专业人士认为他们应该只有机会接触到真实的材料,而考古学和遗产专业人士和非专业人士都认为,如果有助于学生的教育,所有学科都应该有机会接触到材料。
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引用次数: 0
Willingness toward donation in Mexico and the influence of personality 墨西哥的捐赠意愿与个性的影响
IF 0.3 Q4 ANATOMY & MORPHOLOGY Pub Date : 2023-05-01 DOI: 10.52083/xxes3736
Daniela C. Gonzalez-Cruz, Rodrigo E Elizondo Omaña, Alejandro Quiroga Garza, J. H. Martínez Garza, D. de la Fuente Villarreal, Oscar de la Garza Castro, Katia Guzman Avilan, Jorge Gutierrez de la O, Santos Guzmán López
Organ and body donation are key elements in health sciences. This study examines the perception of the population toward organ and body donation and how it may be influenced by personality traits. A cross-sectional study was designed, in which a questionnaire including items of demographic data and attitudes toward organ and body donation were distributed among the general population. A validated questionnaire for the screening of personality disorders was applied as well. 202 questionnaires were obtained, 76 (37.6%) from men and 126 (62.4%) from women. A total of 95.2% of women and 93.4% of men responded to be in favor of organ donation (p>0.05). However, only 40.3 % of women and 37.8% of men were in favor of body donation. Sixty-eight percent of participants had a probable personality disorder. Of those against body donation, 67% had a probable personality disorder. Body donation is not a well-known option among the Mexican population. However, for a program to be feasible, it is necessary to raise public awareness regarding donation and its implications to achieve greater engagement.
器官和遗体捐赠是健康科学的关键要素。本研究考察了人们对器官和身体捐赠的看法,以及它如何受到人格特质的影响。设计了一项横断面研究,在普通人群中分发了一份调查问卷,其中包括人口统计数据和对器官和遗体捐赠的态度。同时采用了一份有效的人格障碍筛查问卷。共获得问卷202份,其中男性76份(37.6%),女性126份(62.4%)。95.2%的女性和93.4%的男性表示赞成器官捐献(p>0.05)。然而,只有40.3%的女性和37.8%的男性赞成捐献遗体。68%的参与者可能有人格障碍。在反对遗体捐献的人中,67%的人可能有人格障碍。在墨西哥民众中,遗体捐赠并不是一个广为人知的选择。然而,要使一个项目可行,必须提高公众对捐赠及其影响的认识,以实现更大的参与。
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引用次数: 0
Velamentous cord insertion - Gross and histological examination 静脉索插入-大体和组织学检查
IF 0.3 Q4 ANATOMY & MORPHOLOGY Pub Date : 2023-05-01 DOI: 10.52083/ytkg6205
Fariha Sabeen
Velamentous cord insertion is an abnormal cord insertion in which the umbilical vessels diverge as they traverse between the amnion and chorion before reaching the placenta. The present case study is an incidental finding during a cesarean section. A 30-year-old woman with 37 weeks of pregnancy, gravid 1, presented with bleeding per vagina. Previous ultrasonography reports confirmed the presence of a low-lying placenta. However, the site of cord insertion was not mentioned in her reports. On cesarean section, a healthy male baby was delivered. The placenta had velamentous cord insertion. Approximately 12 cm of vessels traversed the membranes. In the present case study, the umbilical cord was thoroughly examined, both grossly and histologically. For better understanding, the umbilical cord was also compared with a normal umbilical cord. Morphologically, the length and diameter of the cord were in normal range and blood vessels were patent. Histologically, the slides showed the absence of Wharton’s jelly on the cord. Velamentous cord insertion can lead to many unwanted complications like preterm birth, post-partum hemorrhage, and even fetal death. Abdominal ultrasound can be used to visualize the insertion of the cord; however, it often goes unnoticed, as the insertion site is usually obscured by the fetus. Moreover, maternal obesity and posterior placenta make the diagnosis even more difficult. This case study highlights the necessity to pre-diagnose velamentous cord insertion. It can be done with the help of trans-vaginal ultrasound and color Doppler imaging of the cord vessels.
膜状脐带插入是一种异常的脐带插入,其中脐带血管在到达胎盘之前在羊膜和绒毛膜之间发散。本病例是在剖宫产术中偶然发现的。一位30岁女性,怀孕37周,妊娠1,表现为每个阴道出血。先前的超声检查报告证实了低胎盘的存在。然而,在她的报告中没有提到脐带插入的位置。通过剖宫产,生下了一个健康的男婴。胎盘有膜状脐带插入。大约12厘米的血管穿过膜。在本病例研究中,脐带进行了彻底的检查,包括肉眼检查和组织学检查。为了更好地理解,脐带也与正常脐带进行了比较。形态学上,脐带长度和直径在正常范围内,血管通畅。组织学上,幻灯片显示脊髓上没有沃顿氏胶质。静脉脐带插入可导致许多不必要的并发症,如早产,产后出血,甚至胎儿死亡。腹部超声可以用来观察脐带的插入;然而,它经常被忽视,因为插入位置通常被胎儿遮挡。此外,产妇肥胖和后胎盘使诊断更加困难。本病例研究强调了预先诊断膜状脊髓插入的必要性。它可以通过阴道超声和脐带血管的彩色多普勒成像来完成。
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引用次数: 0
Complete thyrohyoid calcification: a case from the 18th century and literature review 18世纪甲状腺舌骨完全钙化1例及文献回顾
IF 0.3 Q4 ANATOMY & MORPHOLOGY Pub Date : 2023-05-01 DOI: 10.52083/mzzj8543
L. Canales, A. Malgosa, José Soto Liria, J. Sañudo, A. Isidro
Calcifications in the thyrohyoid ligament are uncommon and usually involve triticeal cartilage. This report analyzes an uncommon thyrohyoid ossification in an individual from the 18th century. To study this ossification, an X-ray analysis was made and the measurements of the different segments of the bone were taken to compare to other cases. The radiographic images show a complete thyrohyoid ossification arising from the great horn of the hyoid with the non-clear presence of the triticeal cartilage. This form is rarely taken into account in typology studies so far, although its etiology is theorized. Different types of calcifications must be considered when clarifying terminologies, investigating their etiology, and whether they involve the triticeal cartilage. Literature review has been carried out to clarify the different types of calcifications in the thyrohyoid ligament and its terminology.
甲状舌骨韧带的钙化并不常见,通常累及三角软骨。本报告分析了一例来自18世纪的罕见甲状腺舌骨骨化。为了研究这种骨化,进行了x射线分析,并对骨头的不同部分进行了测量,以与其他病例进行比较。x线图像显示完整的甲状舌骨骨化,起源于舌骨大角,并可见不清楚的小软骨。迄今为止,这种形式在类型学研究中很少被考虑到,尽管它的病因是理论化的。不同类型的钙化必须考虑在澄清术语,调查其病因,以及他们是否涉及小臼齿软骨。本文对甲状舌骨韧带钙化的不同类型及其术语进行了综述。
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引用次数: 0
ANTONIO DE GIMBERNAT Y ARBOS (1734-1816) 安东尼奥·德·金伯纳特和阿尔博斯(1734-1816)
IF 0.3 Q4 ANATOMY & MORPHOLOGY Pub Date : 2023-05-01 DOI: 10.52083/tkfp3489
Pedro Mestres Ventura
BOOK REVIEW
书评
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引用次数: 0
Anatomical Sciences from a translational perspective: Bibliometric analysis 翻译视角下的解剖学:文献计量学分析
IF 0.3 Q4 ANATOMY & MORPHOLOGY Pub Date : 2023-05-01 DOI: 10.52083/dlwg3599
Pablo Álvarez, Arturo Argüello, Marta Reyes
In the field of human morphology, despite its growing interest in translational anatomy research, its contributions are often unknown. Scientific articles and patents are highly reliable sources of knowledge for measuring scientific progress and technology transfer. The aim of this article is a bibliometric study of the potential of anatomical translational research. Our methodological framework has consisted of a combination of the analysis of two variables: 1) academic papers, and 2) patents of anatomical scientific achievements. The established time range has been 2000-2020 and the database used The Lens (https://www.lens.org), establishing “anatomical science” as the keyword. In the systematic analysis, 11,547 scientific documents and 1,511 patent registrations have been carried out; inclusion criteria were applied to both groups to identify their quantitative and qualitative trends. Our results identified that scientific articles on translational anatomical achievements have an exponential growth rate similar to the growth of patent applications for translational anatomical sciences. The maximum number of contributions of journal articles and patents corresponds to the temporal range of 2010 and 2020, with 2020 being the most productive year; academic documents represented 54.90% and patents produced represented 45.08%, which are significant data if they are compared with the year 2000, when the respective percentages were 76.40% and 23.50%, an indicator of a clear increase in the culture of patentability and the growing interest in translational anatomical research. The records of granted patents were 747 and 487 patent applications, which are significant data for the growth of the culture of patentability as well as the quality of the patents, since those granted represent 60.40%. These results identify the strong growth of anatomical science and its interest in the transfer of scientific achievements.
在人类形态学领域,尽管人们对翻译解剖学的研究越来越感兴趣,但它的贡献往往是未知的。科学论文和专利是衡量科学进步和技术转让的高度可靠的知识来源。本文的目的是对解剖学翻译研究的潜力进行文献计量学研究。我们的方法框架由两个变量的分析组合组成:1)学术论文,2)解剖学科学成果的专利。建立的时间范围为2000-2020年,数据库使用The Lens (https://www.lens.org),以“解剖科学”为关键词。在系统分析中,共完成科学文献11547篇,专利注册1511项;纳入标准适用于两组,以确定其定量和定性趋势。我们的研究结果表明,关于转化解剖学成果的科学文章具有与转化解剖学专利申请增长相似的指数增长率。期刊论文和专利贡献的最大数量对应于2010年和2020年的时间范围,其中2020年是产出最高的年份;学术文献占54.90%,专利产生占45.08%,如果与2000年相比,这是一个重要的数据,当时的比例分别为76.40%和23.50%,这表明可专利性文化明显增加,对转化解剖学研究的兴趣日益浓厚。专利授权件数分别为747件和487件,占专利授权件数的60.40%,是促进可专利性文化发展和提高专利质量的重要数据。这些结果表明解剖科学的强劲增长及其对科学成果转移的兴趣。
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引用次数: 0
Morphological and clinical significance of the suprameatal region: a topographic study 表上区形态学和临床意义:一项地形学研究
IF 0.3 Q4 ANATOMY & MORPHOLOGY Pub Date : 2023-05-01 DOI: 10.52083/jvqj5380
B. Tuğtağ Demir, Dilara Patat, D. Akduman
The suprameatal approach, which does not require mastoidectomy, uses the method of tunneling over the facial nerve to enter the middle ear in cochlear implantation. Even if the SMA approach is also used to drain the mastoid antrum, the depth of the triangle and protrusion types may be important for surgical approaches in this region. This descriptive study was conducted with 58 dry skulls found in the laboratories of the University Faculty of Medicine. Important landmarks were used on the left and right sides of the skulls. All the distances were measured with a vernier caliper to the nearest millimeter. No statistical significance was found between the right and left sides (p>0.05). The border lengths of the suprameatal triangle were respectively 14.88±1.67 mm, 18.17±1.09 mm, 14.56±1.59 mm on the right and 15.34±1.65 mm, 19.01±0.56 mm, 15.89±0.52 mm on the left. Consequently, it was determined that the left side was wider than the right, and there was statistical significance between the sides. The mean ST area was found to be 112.7±16.90 mm2. The crest was observed mostly on the right side (n=30 (51.72%)), and the triangular suprameatal protrusion was observed mostly on the right side (n=10 (31.03%)). We think that knowing this area’s borders and morphological features well, nominated before the surgical procedure, will be a guide in preventing possible operative and postoperative complications.
在人工耳蜗植入术中,经面神经隧道入路进入中耳,不需要切除乳突。即使SMA入路也用于引流乳突腔,三角的深度和突出类型对于该区域的手术入路可能是重要的。这项描述性研究是用在大学医学院实验室里发现的58个干头骨进行的。重要的标志被用在头骨的左右两侧。所有的距离都是用游标卡尺测量的,精确到毫米。左右侧差异无统计学意义(p>0.05)。右侧为14.88±1.67 mm、18.17±1.09 mm、14.56±1.59 mm,左侧为15.34±1.65 mm、19.01±0.56 mm、15.89±0.52 mm。因此,确定左侧比右侧宽,并且两侧之间存在统计学意义。平均ST区面积为112.7±16.90 mm2。冠状突起多见于右侧(n=30(51.72%)),三角型上突多见于右侧(n=10(31.03%))。我们认为在手术前了解该区域的边界和形态特征,将对预防可能的手术和术后并发症起到指导作用。
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引用次数: 0
期刊
European journal of anatomy
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