European urology focus最新文献

{"title":"The Urinary Microbiome Is a Potential Driver of Urinary Tract Pathology Through Multiple Mechanisms Including Deglucuronidation and DNA Damage","authors":"Julian R. Marchesi , Marcus J. Drake","doi":"10.1016/j.euf.2024.08.009","DOIUrl":"10.1016/j.euf.2024.08.009","url":null,"abstract":"","PeriodicalId":12160,"journal":{"name":"European urology focus","volume":"10 5","pages":"Pages 683-685"},"PeriodicalIF":4.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “A systematic review and meta-analysis on the impact of infertility on men’s general health” [Eur. Urol. Focus (2023) 10(1):98–106.]","authors":"Giuseppe Fallara , Edoardo Pozzi , Federico Belladelli , Luca Boeri , Paolo Capogrosso , Giovanni Corona , Alessia D'Arma , Massimo Alfano , Francesco Montorsi , Andrea Salonia","doi":"10.1016/j.euf.2024.01.001","DOIUrl":"10.1016/j.euf.2024.01.001","url":null,"abstract":"","PeriodicalId":12160,"journal":{"name":"European urology focus","volume":"10 5","pages":"Pages 869-871"},"PeriodicalIF":4.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139110927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic-sparing Strategies for Prevention of Recurrent Urinary Tract Infection","authors":"Guglielmo Mantica , Tommaso Cai , José Medina , Jennifer Kranz , Gernot Bonkat , European Association of Urology Guidelines Panel on Urological Infections","doi":"10.1016/j.euf.2024.07.008","DOIUrl":"10.1016/j.euf.2024.07.008","url":null,"abstract":"","PeriodicalId":12160,"journal":{"name":"European urology focus","volume":"10 5","pages":"Pages 700-701"},"PeriodicalIF":4.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Fabrizio Di Maida, Anna Cadenar, Andrea Mari, and Andrea Minervini’s Letter to the Editor re: Xuesong Li, Weifeng Xu, Shubo Fan, et al. Robot-assisted Partial Nephrectomy with the Newly Developed KangDuo Surgical Robot Versus the da Vinci Si Surgical System: A Double-center Prospective Randomized Controlled Noninferiority Trial. Eur Urol Focus 2023:9:133–40","authors":"Xuesong Li , Weifeng Xu , Shubo Fan , Shengwei Xiong , Jie Dong , Jie Wang , Xiaofei Dai , Kunlin Yang , Yi Xie , Guanghua Liu , Chang Meng , Zheng Zhang , Lin Cai , Cuijian Zhang , Zhongyuan Zhang , Zhigang Ji , Cheng Shen , Liqun Zhou","doi":"10.1016/j.euf.2023.03.022","DOIUrl":"10.1016/j.euf.2023.03.022","url":null,"abstract":"","PeriodicalId":12160,"journal":{"name":"European urology focus","volume":"10 5","pages":"Pages 860-861"},"PeriodicalIF":4.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review on the Impact of Quality Assurance Programs on Outcomes after Radical Prostatectomy","authors":"Sophia H. van der Graaf ,&nbsp;Marinus J. Hagens ,&nbsp;Hans Veerman ,&nbsp;Ton A. Roeleveld ,&nbsp;Jakko A. Nieuwenhuijzen ,&nbsp;Esther M.K. Wit ,&nbsp;Michel W.J.M. Wouters ,&nbsp;Stevie van der Mierden ,&nbsp;R. Jeroen A. van Moorselaar ,&nbsp;Harrie P. Beerlage ,&nbsp;André N. Vis ,&nbsp;Pim J. van Leeuwen ,&nbsp;Henk G. van der Poel","doi":"10.1016/j.euf.2024.03.004","DOIUrl":"10.1016/j.euf.2024.03.004","url":null,"abstract":"<div><h3>Background and objective</h3><div>The implementation of quality assurance programs (QAPs) within urological practice has gained prominence; yet, their impact on outcomes after radical prostatectomy (RP) remains uncertain. This paper aims to systematically review the current literature regarding the implementation of QAPs and their impact on outcomes after robot-assisted RP, laparoscopic RP, and open prostatectomy, collectively referred to as RP.</div></div><div><h3>Methods</h3><div>A systematic Embase, Medline (OvidSP), and Scopus search was conducted, according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) process, on January 12, 2024. Studies were identified and included if these covered implementation of QAPs and their impact on outcomes after RP. QAPs were defined as any intervention seeking quality improvement through critically reviewing, analyzing, and discussing outcomes. Included studies were assessed critically using the Risk of Bias in Nonrandomized Studies of Interventions (ROBINS-I) tool, with results summarized narratively.</div></div><div><h3>Key findings and limitations</h3><div>Ten included studies revealed two methodological strategies: periodic performance feedback and surgical video assessments. Despite conceptual variability, QAPs improved outcomes consistently (ie, surgical margins, urine continence, erectile function, and hospital readmissions). Of the two strategies, video assessments better identified suboptimal surgical practice and technical errors. Although the extent of quality improvements did not appear to correlate with the frequency of QAPs, there was an apparent correlation with whether or not outcomes were evaluated collectively.</div></div><div><h3>Conclusions and clinical implications</h3><div>Current findings suggest that QAPs have a positive impact on outcomes after RP. Caution in interpretation due to limited data is advised. More extensive research is required to explore how conceptual differences impact the extent of quality improvements.</div></div><div><h3>Patient summary</h3><div>In this paper, we review the available scientific literature regarding the implementation of quality assurance programs and their impact on outcomes after radical prostatectomy. The included studies offered substantial support for the implementation of quality assurance programs as an incentive to improve the quality of care continuously.</div></div>","PeriodicalId":12160,"journal":{"name":"European urology focus","volume":"10 5","pages":"Pages 754-760"},"PeriodicalIF":4.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140780729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacterial Vaccines for the Management of Recurrent Urinary Tract Infections: A Systematic Review and Meta-analysis","authors":"Quentin Mak ,&nbsp;Julian Greig ,&nbsp;Prokar Dasgupta ,&nbsp;Sachin Malde ,&nbsp;Nicholas Raison","doi":"10.1016/j.euf.2024.04.002","DOIUrl":"10.1016/j.euf.2024.04.002","url":null,"abstract":"<div><h3>Background and objective</h3><div>Several bacterial immunisations have been developed to reduce the socioeconomic burden of urinary tract infections (UTIs) and the use of prophylactic antibiotics in the management of recurrent UTIs (rUTIs). This systematic review evaluates the effectiveness of vaccinations in preventing rUTIs.</div></div><div><h3>Methods</h3><div>Medline, Embase, and Web of Science were searched from inception to December 2023. Data were collected from cohort studies with a comparator arm and randomised controlled trials (RCTs) investigating vaccination efficacy in adult rUTI patients according to predefined selection criteria (PROSPERO registration: CRD42022356662). A pooled analysis took place for RCTs, with a subgroup analysis for vaccine types and booster regimens. Other studies were synthesised narratively. The risk of bias was assessed using Cochrane Risk-of-Bias tools. The Grading of Recommendations, Assessment, Development, and Evaluations framework evaluated the quality of evidence.</div></div><div><h3>Key findings and limitations</h3><div>Fourteen comparative studies were selected, including 2822 patients across five vaccination types. The pooled risk ratio of eight placebo-controlled studies of the percentage of patients UTI free in the short term (6–12 mo) was 1.52 (95% confidence interval [CI] 1.05–2.20) with a number needed to treat of 6.45 (95% CI 2.80–64.80). There is substantial heterogeneity and a slight risk of a publication bias.</div></div><div><h3>Conclusions and clinical implications</h3><div>There is limited evidence to suggest that vaccinations are effective at reducing UTI recurrence in adult female patients in the short term. Owing to low quality of evidence, the literature requires further long-term RCTs with large sample sizes utilising standardised definitions for conclusive evidence of the long-term efficacy of vaccination in rUTI prevention.</div></div><div><h3>Patient summary</h3><div>We explored whether vaccines could help stop urinary tract infections (UTIs) from happening again. The latest information shows that these vaccines are safe and may help lower the chances of women getting UTIs again for about 6–12 mo.</div></div>","PeriodicalId":12160,"journal":{"name":"European urology focus","volume":"10 5","pages":"Pages 761-769"},"PeriodicalIF":4.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140783245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benign Prostatic Hyperplasia Surgery: A Snapshot of Trends, Costs, and Surgical Retreatment Rates in the USA","authors":"Francesco Ditonno ,&nbsp;Celeste Manfredi ,&nbsp;Leslie Claire Licari ,&nbsp;Eugenio Bologna ,&nbsp;Antonio Franco ,&nbsp;Savio D. Pandolfo ,&nbsp;Marco De Sio ,&nbsp;Cosimo De Nunzio ,&nbsp;Cristian Fiori ,&nbsp;Edward E. Cherullo ,&nbsp;Ephrem O. Olweny ,&nbsp;Alessandro Antonelli ,&nbsp;Riccardo Autorino","doi":"10.1016/j.euf.2024.04.006","DOIUrl":"10.1016/j.euf.2024.04.006","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;An increasing number of novel surgical treatments (NSTs) for benign prostatic hyperplasia (BPH) have been proposed over time to achieve similar functional outcomes, but better perioperative and sexual outcomes than traditional procedures.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To assess the trends in the utilization and costs of BPH surgical procedures over the past decade, and to analyze the need for surgical retreatment after each procedure.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Design, setting, and participants&lt;/h3&gt;&lt;div&gt;A retrospective observational population-based analysis was conducted using the PearlDiver Mariner (PearlDiver Technologies, Colorado Springs, CO, USA) database, including all-payer nationally available claims records collected from 2011 to 2022.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Outcome measurements and statistical analysis&lt;/h3&gt;&lt;div&gt;The number and type of BPH surgical procedures per year, costs associated with each BPH surgical treatment, incidence of BPH surgical retreatment rate, and time to BPH surgical retreatment were assessed. Negative binomial regression and Cochran-Armitage test were used for the temporal trend analysis. A multivariable logistic regression analysis evaluated the predictors of BPH surgical retreatment.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results and limitations&lt;/h3&gt;&lt;div&gt;In the study period, 274 808 patients received surgical treatment for BPH. The most common procedure was transurethral resection of the prostate (TURP; 71.7%). The overall utilization of BPH surgical treatment increased over the study period. Traditional surgery remained most performed for the entire period (87.8%), but a statistically significantly rising trend of NSTs was recorded. The mean reimbursements paid per procedure was 1.43 times higher (&lt;em&gt;p&lt;/em&gt; &lt; 0.001) for NSTs than for traditional procedures. The surgical retreatment rate was 9.4%. The mean time to surgical retreatment was 25.3 mo, with 85.5% of cases re-treated within 5 yr. At the multivariable analysis, transurethral incision of the prostate, photoselective vaporization of the prostate, prostatic urethral lift, convective water vapor energy, and prostatic artery embolization had a significantly greater likelihood of surgical retreatment than TURP. Holmium/thulium laser enucleation of the prostate (HoLEP/ThuLEP), open simple prostatectomy (SP), and laparoscopic/robot-assisted SP were associated with a lower probability of resurgery than TURP, but a similar probability between these procedures. Retrospective design and a lack of relevant clinical data were the main limitations.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;Over the past decade, there has been a progressive increase in the adoption of NSTs. The rate of surgical retreatment appears &lt;10%, with patients undergoing SP and HoLEP/ThuLEP experiencing a statistically significantly lower probability of surgical retreatment.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Patient summary&lt;/h3&gt;&lt;div&gt;We investigated the trends, costs, and surgical retreatments of ","PeriodicalId":12160,"journal":{"name":"European urology focus","volume":"10 5","pages":"Pages 826-832"},"PeriodicalIF":4.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140759313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Rano Matta, Refik Saskin, Sarah Neu, et al. Predicting Mirabegron Treatment Response in Patients with Overactive Bladder: A Post Hoc Analysis of Data from Clinical Trials. Eur Urol Focus 2023;9:957–65","authors":"Yu-Hsiang Lin ,&nbsp;Han-Yu Tsai ,&nbsp;Shu-Han Tsao","doi":"10.1016/j.euf.2024.02.009","DOIUrl":"10.1016/j.euf.2024.02.009","url":null,"abstract":"","PeriodicalId":12160,"journal":{"name":"European urology focus","volume":"10 5","pages":"Pages 866-867"},"PeriodicalIF":4.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140140080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Stamatio Katsimperis, Lazaros Tzelves, Zafer Tandogdu, et al. Complications After Radical Cystectomy: A Systematic Review and Meta-analysis of Randomized Controlled Trials with a Meta-regression Analysis. Eur Urol Focus 2023;9:920–9","authors":"Francesco Montorsi,&nbsp;Marco Moschini,&nbsp;Giuseppe Rosiello,&nbsp;Andrea Salonia,&nbsp;Alberto Briganti","doi":"10.1016/j.euf.2024.03.009","DOIUrl":"10.1016/j.euf.2024.03.009","url":null,"abstract":"","PeriodicalId":12160,"journal":{"name":"European urology focus","volume":"10 5","pages":"Page 858"},"PeriodicalIF":4.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycomimetics as Candidates for Treatment and Prevention of Catheter-associated Biofilms Formed by Pseudomonas aeruginosa","authors":"Christian Vogel ,&nbsp;Katharina Rox ,&nbsp;Florian Wagenlehner ,&nbsp;Alexander Titz","doi":"10.1016/j.euf.2024.08.011","DOIUrl":"10.1016/j.euf.2024.08.011","url":null,"abstract":"<div><div>Bacteria develop biofilms for protection and persistent colonization. Biofilms of pathogenic bacteria can lead to serious medical problems. Bacterial biofilms on catheters used in the treatment of urinary tract diseases represent a major challenge for antibiotic therapy. Several attempts to eradicate biofilms using classical antibiotics and various alternatives, including antibiotic treatment of surfaces, surfaces that release silver ions, and surfaces with anti-adhesive properties, have not shown clinical efficacy in biofilm prevention or removal. <em>Pseudomonas aeruginosa</em> is one of the most problematic biofilm-forming uropathogens and accounts for approximately 10% of urinary tract infections. Novel glycomimetics that inhibit bacterial lectins have shown promising results in the prevention of <em>P. aeruginosa</em> biofilms and in interference with bacterial virulence. This mini-review summarizes the status of glycomimetic development and provides a perspective on their use in clinical practice.</div></div><div><h3>Patient summary</h3><div>For patients with recurrent urinary tract infections and patients needing long-term catheter use to manage urinary problems, biofilms formed by bacteria can be a problem and are difficult to treat. New compounds that mimic carbohydrates, called glycomimetics, have shown promise in inhibiting these bacteria and the biofilms they form. More research on these compounds is needed before they can be used to treat patients.</div></div>","PeriodicalId":12160,"journal":{"name":"European urology focus","volume":"10 5","pages":"Pages 720-721"},"PeriodicalIF":4.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}