首页 > 最新文献

Forensic science international最新文献

英文 中文
Benchmarking of proficiency tests for the fingerprint field
IF 2.2 3区 医学 Q1 MEDICINE, LEGAL Pub Date : 2025-02-01 DOI: 10.1016/j.forsciint.2025.112384
Andy Bécue , Alexandre Anthonioz , Guy Harris , Roger Heredia , Aldo Mattei , Christophe Rion , Alina Saggau
Since 2015, European fingerprint service providers carrying out laboratory activities must be EN ISO/IEC 17025 accredited. Consequently, relevant and reliable proficiency tests are required by those accredited forensic laboratories to regularly assess and certify their analytical capabilities. In this context, Work package #10 of the ENFSI-EU funded project named "Competency, Education, Research, Testing, Accreditation, and Innovation in Forensic Science" (Grant #101051099) aimed at proposing guidance to forensic laboratories for the selection of proficiency tests in the fields of fingermark visualization, imaging, and comparison/identification. In this paper, the methodology that has been set and followed is described, and the resulting guidance document presented. Additionally, a critical overview of the current market of commercial proficiency tests dedicated to the fingerprint field is proposed.
{"title":"Benchmarking of proficiency tests for the fingerprint field","authors":"Andy Bécue ,&nbsp;Alexandre Anthonioz ,&nbsp;Guy Harris ,&nbsp;Roger Heredia ,&nbsp;Aldo Mattei ,&nbsp;Christophe Rion ,&nbsp;Alina Saggau","doi":"10.1016/j.forsciint.2025.112384","DOIUrl":"10.1016/j.forsciint.2025.112384","url":null,"abstract":"<div><div>Since 2015, European fingerprint service providers carrying out laboratory activities must be EN ISO/IEC 17025 accredited. Consequently, relevant and reliable proficiency tests are required by those accredited forensic laboratories to regularly assess and certify their analytical capabilities. In this context, Work package #10 of the ENFSI-EU funded project named \"Competency, Education, Research, Testing, Accreditation, and Innovation in Forensic Science\" (Grant #101051099) aimed at proposing guidance to forensic laboratories for the selection of proficiency tests in the fields of fingermark visualization, imaging, and comparison/identification. In this paper, the methodology that has been set and followed is described, and the resulting guidance document presented. Additionally, a critical overview of the current market of commercial proficiency tests dedicated to the fingerprint field is proposed.</div></div>","PeriodicalId":12341,"journal":{"name":"Forensic science international","volume":"367 ","pages":"Article 112384"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
“Body farm time machine”: Results from taphonomic study of burial and underwater contexts “尸体农场时光机”:埋藏和水下环境的埋藏学研究结果。
IF 2.2 3区 医学 Q1 MEDICINE, LEGAL Pub Date : 2025-02-01 DOI: 10.1016/j.forsciint.2024.112313
A. Macho-Callejo , L. Huidobro-Pasero , E. Honrubia-Clemente , J. Santos-González , Y. Fernández-Jalvo , A. Gutiérrez
Experimental taphonomy and neotaphonomic monitoring have become two relevant tools in interpreting modifications, and most especially in forensic investigations. Research facilities, where human decomposition experiments are carried out under controlled situations, provide a better understanding of the tapho–forensic history of cadaveric remains under specific environments and in different situations or even climates. There are, however, limitations of time to monitoring, such as space for experimentation and ethics, that do not always allow to carry out these types of investigations. The study presented here investigates the early post mortem modifications of the cadaveric state using animal models (pig autopods) simulating different forensic scenarios in accelerated time, under controlled climatic parameters, in different environmental contexts. This study was carried out under semi-arid conditions programmed in a climatic chamber. The aim of this study is to open a new range of knowledge in experimental taphonomy. As results of this experiment, different types of cadaveric states (such as total skeletonization, skeletonization with dry putrid matter, saponification and mummification) were obtained related to the type of contexts in which animal models were deposited (submerged or buried in wet or dry sediment).
实验:触音学和新触音学监测已经成为解释修饰的两种相关工具,尤其是在法医调查中。在受控情况下进行人体分解实验的研究设施,可以更好地了解在特定环境和不同情况甚至气候下的尸体遗骸的tapho-forensic历史。然而,监测的时间有限,例如实验空间和伦理方面的限制,并不总是允许进行这类调查。本研究采用动物模型(猪自残体),在不同的环境背景下,在可控的气候参数下,在加速时间内模拟不同的法医场景,研究了尸体状态的早期死后改变。这项研究是在半干旱条件下进行的,在一个气候室进行编程。本研究的目的是在实验地形学中开辟一个新的知识范围。实验结果表明,不同类型的尸体状态(如完全骨骼化、带有干腐物质的骨骼化、皂化和木乃伊化)与动物模型沉积的环境类型(淹没或埋在湿或干沉积物中)有关。
{"title":"“Body farm time machine”: Results from taphonomic study of burial and underwater contexts","authors":"A. Macho-Callejo ,&nbsp;L. Huidobro-Pasero ,&nbsp;E. Honrubia-Clemente ,&nbsp;J. Santos-González ,&nbsp;Y. Fernández-Jalvo ,&nbsp;A. Gutiérrez","doi":"10.1016/j.forsciint.2024.112313","DOIUrl":"10.1016/j.forsciint.2024.112313","url":null,"abstract":"<div><div>Experimental taphonomy and neotaphonomic monitoring have become two relevant tools in interpreting modifications, and most especially in forensic investigations. Research facilities, where human decomposition experiments are carried out under controlled situations, provide a better understanding of the tapho–forensic history of cadaveric remains under specific environments and in different situations or even climates. There are, however, limitations of time to monitoring, such as space for experimentation and ethics, that do not always allow to carry out these types of investigations. The study presented here investigates the early p<em>ost mortem</em> modifications of the cadaveric state using animal models (pig autopods) simulating different forensic scenarios in accelerated time, under controlled climatic parameters, in different environmental contexts. This study was carried out under semi-arid conditions programmed in a climatic chamber. The aim of this study is to open a new range of knowledge in experimental taphonomy. As results of this experiment, different types of cadaveric states (such as total skeletonization, skeletonization with dry putrid matter, saponification and mummification) were obtained related to the type of contexts in which animal models were deposited (submerged or buried in wet or dry sediment).</div></div>","PeriodicalId":12341,"journal":{"name":"Forensic science international","volume":"367 ","pages":"Article 112313"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do migrants better in reintegration? A multicenter follow-up study on re-delinquency, addiction-related behavior and resocialization after German Forensic Addiction Treatment 移民能否更好地融入社会?德国法医学成瘾治疗后再犯罪、成瘾相关行为及再社会化的多中心随访研究。
IF 2.2 3区 医学 Q1 MEDICINE, LEGAL Pub Date : 2025-02-01 DOI: 10.1016/j.forsciint.2024.112311
Jan Querengässer , Adelheid Bezzel
In Germany, Forensic Addiction Treatment serves the purpose of reintegration into society. Patients with a migration background are over-represented, show slightly higher rates of premature termination and exhibit less successful outcomes. However, outcome research was often limited by conceptual ambiguities and insufficient control for confounding variables. In the present article, we defined reintegration as a comprehensive concept comprising three domains (re-delinquency, addiction-related behavior, resocialization). In a multicenter approach, 466 migrant patients were compared on 35 catamnestic variables to a group of non-migrants matched on the variables sex, main offense, main diagnostic group and age at discharge. For to seek evidence for and against interrelation, we applied both inferential and Bayesian statistics. Both groups show almost the same substance use behaviors and identical re-delinquency rates, with some tendency toward more serious re-offenses among non-migrants. The migrant-group combines more favorable patterns on relevant indicators of resocialization. However, while treatment is proving equally successful in terms of its core purpose of reintegration, it does not succeed in overcoming systemic barriers to accessing the general health care system, as migrants show more reluctant help-seeking behaviors. This, in turn, could increase the risk of long-term re-delinquency due to a lack of adequate post-forensic support. Hence, barriers should be reduced and treatment offers should be adapted to migrants’ needs.
在德国,法医成瘾治疗服务于重新融入社会的目的。具有移民背景的患者比例过高,早产率略高,成功率较低。然而,结果研究经常受到概念模糊和对混杂变量控制不足的限制。在本文中,我们将重返社会定义为一个综合概念,包括三个领域(再犯罪,成瘾相关行为,再社会化)。在一项多中心方法中,466名移民患者与一组非移民患者在35个动态变量上进行了比较,这些变量在性别、主要罪行、主要诊断组和出院年龄上匹配。为了寻找支持和反对相互关系的证据,我们同时应用了推理统计和贝叶斯统计。这两个群体表现出几乎相同的药物使用行为和相同的再犯罪率,非移民群体有更严重的再犯罪趋势。移民群体在重新社会化的相关指标上结合了更有利的模式。然而,尽管治疗在实现重返社会这一核心目标方面取得了同样的成功,但由于移徙者表现出更不愿意寻求帮助的行为,治疗未能成功克服进入一般卫生保健系统的系统性障碍。反过来,由于缺乏足够的法医后支持,这可能会增加长期再犯罪的风险。因此,应减少障碍,提供的治疗应适应移徙者的需要。
{"title":"Do migrants better in reintegration? A multicenter follow-up study on re-delinquency, addiction-related behavior and resocialization after German Forensic Addiction Treatment","authors":"Jan Querengässer ,&nbsp;Adelheid Bezzel","doi":"10.1016/j.forsciint.2024.112311","DOIUrl":"10.1016/j.forsciint.2024.112311","url":null,"abstract":"<div><div>In Germany, Forensic Addiction Treatment serves the purpose of reintegration into society. Patients with a migration background are over-represented, show slightly higher rates of premature termination and exhibit less successful outcomes. However, outcome research was often limited by conceptual ambiguities and insufficient control for confounding variables. In the present article, we defined reintegration as a comprehensive concept comprising three domains (re-delinquency, addiction-related behavior, resocialization). In a multicenter approach, 466 migrant patients were compared on 35 catamnestic variables to a group of non-migrants matched on the variables sex, main offense, main diagnostic group and age at discharge. For to seek evidence for and against interrelation, we applied both inferential and Bayesian statistics. Both groups show almost the same substance use behaviors and identical re-delinquency rates, with some tendency toward more serious re-offenses among non-migrants. The migrant-group combines more favorable patterns on relevant indicators of resocialization. However, while treatment is proving equally successful in terms of its core purpose of reintegration, it does not succeed in overcoming systemic barriers to accessing the general health care system, as migrants show more reluctant help-seeking behaviors. This, in turn, could increase the risk of long-term re-delinquency due to a lack of adequate post-forensic support. Hence, barriers should be reduced and treatment offers should be adapted to migrants’ needs.</div></div>","PeriodicalId":12341,"journal":{"name":"Forensic science international","volume":"367 ","pages":"Article 112311"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FIGG at 5: An update on U.S. public perspectives on forensic investigative genetic genealogy five years after its introduction to criminal investigations
IF 2.2 3区 医学 Q1 MEDICINE, LEGAL Pub Date : 2025-02-01 DOI: 10.1016/j.forsciint.2025.112372
Christi J. Guerrini , Jill O. Robinson , Mohamed I. Elsaid , Whitney Bash Brooks , Ariel Levchenko , Stephanie M. Fullerton , Sara Huston , Norah L. Crossnohere , John F.P. Bridges , Jacklyn M. Dahlquist , Louiza Kalokairinou , Diana Madden , CeCe Moore , Amy L. McGuire
In 2018, after law enforcement announced it had used a technique called forensic investigative genetic genealogy (FIGG) to identify the Golden State Killer, we conducted a U.S. general population survey and found most respondents supported using FIGG to solve violent crimes. Since then, FIGG has helped close hundreds of criminal cases, but it also has weathered controversies. On FIGG's fifth anniversary, we conducted an expanded, follow-up survey with U.S.-based participants to determine if public opinion had changed and found continued support for FIGG across most applications. The same proportion (91 %) of respondents in the 2018 and 2023 surveys endorsed using FIGG in genetic genealogy databases to help identify perpetrators of violent crimes. Similar to the 2018 survey, only 57 % of respondents supported FIGG to help identify perpetrators of non-violent crimes. The results indicate that U.S. policies that have been adopted for FIGG are generally consistent with the opinions of our survey respondents over time. Nonetheless, there are opportunities to strengthen FIGG governance with the goal of maintaining public trust in the technique.
{"title":"FIGG at 5: An update on U.S. public perspectives on forensic investigative genetic genealogy five years after its introduction to criminal investigations","authors":"Christi J. Guerrini ,&nbsp;Jill O. Robinson ,&nbsp;Mohamed I. Elsaid ,&nbsp;Whitney Bash Brooks ,&nbsp;Ariel Levchenko ,&nbsp;Stephanie M. Fullerton ,&nbsp;Sara Huston ,&nbsp;Norah L. Crossnohere ,&nbsp;John F.P. Bridges ,&nbsp;Jacklyn M. Dahlquist ,&nbsp;Louiza Kalokairinou ,&nbsp;Diana Madden ,&nbsp;CeCe Moore ,&nbsp;Amy L. McGuire","doi":"10.1016/j.forsciint.2025.112372","DOIUrl":"10.1016/j.forsciint.2025.112372","url":null,"abstract":"<div><div>In 2018, after law enforcement announced it had used a technique called forensic investigative genetic genealogy (FIGG) to identify the Golden State Killer, we conducted a U.S. general population survey and found most respondents supported using FIGG to solve violent crimes. Since then, FIGG has helped close hundreds of criminal cases, but it also has weathered controversies. On FIGG's fifth anniversary, we conducted an expanded, follow-up survey with U.S.-based participants to determine if public opinion had changed and found continued support for FIGG across most applications. The same proportion (91 %) of respondents in the 2018 and 2023 surveys endorsed using FIGG in genetic genealogy databases to help identify perpetrators of violent crimes. Similar to the 2018 survey, only 57 % of respondents supported FIGG to help identify perpetrators of non-violent crimes. The results indicate that U.S. policies that have been adopted for FIGG are generally consistent with the opinions of our survey respondents over time. Nonetheless, there are opportunities to strengthen FIGG governance with the goal of maintaining public trust in the technique.</div></div>","PeriodicalId":12341,"journal":{"name":"Forensic science international","volume":"367 ","pages":"Article 112372"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating the protein modification and degradation under the influence of petrol and kerosene
IF 2.2 3区 医学 Q1 MEDICINE, LEGAL Pub Date : 2025-02-01 DOI: 10.1016/j.forsciint.2025.112379
Jennifer Johnson , Satish Kumar
During any crime scene investigation, forensic experts gather a variety of evidence in various forms, often degraded, contaminated, or fragmentary in nature. Arson-associated suicide or homicidal cases often result in partial or complete burning of this evidence, making the acquisition of crucial information more challenging. Proteins found in biological samples serve as crucial sources of evidence in criminal investigations due to their abundance within the body and greater stability than another biological macromolecule. Protein based technologies are gaining momentum for investigating wide range of forensic cases. In the present study, we probed different modifications in chicken protein subjecting after burning with petrol and kerosene individually. Structural changes and modifications in burnt chicken meat protein samples were analyzed by various biophysical techniques, such as absorption and fluorescence spectroscopy. Gel-based method such as electrophoresis was performed which showed different degradation patterns under the influence of petrol and kerosene. Our results showed that petrol-exposed meat sample caused higher rate of protein degradation than kerosene exposed samples, over a period of 12 days. Prevalent oxidative modifications, including increased carbonylation and decreased thiol levels were observed in both petrol and kerosene treated sample attributing oxidative stress environment caused by burning. Present study highlights that petrol is more potent in causing damage and protein modification than kerosene. Furthermore, this study elucidates the application of protein-based methods in forensic science, which can serve as a corroborative approach in ascertaining the cause of death in cases of burning, particularly where fuel has been utilized.
{"title":"Investigating the protein modification and degradation under the influence of petrol and kerosene","authors":"Jennifer Johnson ,&nbsp;Satish Kumar","doi":"10.1016/j.forsciint.2025.112379","DOIUrl":"10.1016/j.forsciint.2025.112379","url":null,"abstract":"<div><div>During any crime scene investigation, forensic experts gather a variety of evidence in various forms, often degraded, contaminated, or fragmentary in nature. Arson-associated suicide or homicidal cases often result in partial or complete burning of this evidence, making the acquisition of crucial information more challenging. Proteins found in biological samples serve as crucial sources of evidence in criminal investigations due to their abundance within the body and greater stability than another biological macromolecule. Protein based technologies are gaining momentum for investigating wide range of forensic cases. In the present study, we probed different modifications in chicken protein subjecting after burning with petrol and kerosene individually. Structural changes and modifications in burnt chicken meat protein samples were analyzed by various biophysical techniques, such as absorption and fluorescence spectroscopy. Gel-based method such as electrophoresis was performed which showed different degradation patterns under the influence of petrol and kerosene. Our results showed that petrol-exposed meat sample caused higher rate of protein degradation than kerosene exposed samples, over a period of 12 days. Prevalent oxidative modifications, including increased carbonylation and decreased thiol levels were observed in both petrol and kerosene treated sample attributing oxidative stress environment caused by burning. Present study highlights that petrol is more potent in causing damage and protein modification than kerosene. Furthermore, this study elucidates the application of protein-based methods in forensic science, which can serve as a corroborative approach in ascertaining the cause of death in cases of burning, particularly where fuel has been utilized.</div></div>","PeriodicalId":12341,"journal":{"name":"Forensic science international","volume":"367 ","pages":"Article 112379"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomass loss during decomposition – A new tool in improving PMI estimation?
IF 2.2 3区 医学 Q1 MEDICINE, LEGAL Pub Date : 2025-02-01 DOI: 10.1016/j.forsciint.2025.112389
Natalie Gasz, Michelle Harvey
Determining the minimum post-mortem interval (minPMI) is a useful tool in the investigation of recovered human remains. Though typically based on temperature of remains in the early stages, and insect activity later in the decomposition process, attempts at concealment of remains can hinder these processes. Concealment can affect not only the immediate temperature remains are exposed to but may also result in an inability for insect colonisation to occur. This in turn will hinder the ability to estimate an accurate minPMI, and therefore timeline of events. As such, an understanding of the decomposition patterns where insect access is restricted through physical exclusion may assist in establishing a minPMI. This study utilised still born piglets (n = 48) over a 14-day period in November 2019 – 2022, in Geelong, Victoria, Australia. Piglets were either exposed, (controls), or had complete insect exclusion through a mechanical barrier which still allowed air flow and sampling to occur, with a total of 6 replicates of each condition per year. Piglets were observed daily, with temperature of remains, stage of decomposition, weight, and any insect activity present recorded. Physical barriers successfully excluded insects for the duration of the trial, however produced a greenhouse effect, producing a total of 4500 – 6000 accumulated degree hours (ADH) during the trial while controls only reached 3000–4500ADH in the same period. Bloat phase was severely prolonged in insect exclusion replicates, and subjects did not reach the dry phase by 2700ADH across all years, compared to control piglets which all had entered dry phase by this time. When comparing percentage biomass loss, consistency in overall biomass loss was noted in control piglets, as well as insect exclusion piglets in all trials. Control piglets showed a standard deviation of 5 % biomass loss at any given ADH. Exclusion of insects reduced overall biomass loss in comparison to ADH, however trends in the rate of loss could be established within the corresponding years. This study highlights that biomass loss can occur in the absence of insect exclusion through other decomposition processes, such as bacterial interactions, and may be a useful tool in the estimation of minPMI.
{"title":"Biomass loss during decomposition – A new tool in improving PMI estimation?","authors":"Natalie Gasz,&nbsp;Michelle Harvey","doi":"10.1016/j.forsciint.2025.112389","DOIUrl":"10.1016/j.forsciint.2025.112389","url":null,"abstract":"<div><div>Determining the minimum post-mortem interval (<sub>min</sub>PMI) is a useful tool in the investigation of recovered human remains. Though typically based on temperature of remains in the early stages, and insect activity later in the decomposition process, attempts at concealment of remains can hinder these processes. Concealment can affect not only the immediate temperature remains are exposed to but may also result in an inability for insect colonisation to occur. This in turn will hinder the ability to estimate an accurate <sub>min</sub>PMI, and therefore timeline of events. As such, an understanding of the decomposition patterns where insect access is restricted through physical exclusion may assist in establishing a <sub>min</sub>PMI. This study utilised still born piglets (n = 48) over a 14-day period in November 2019 – 2022, in Geelong, Victoria, Australia. Piglets were either exposed, (controls), or had complete insect exclusion through a mechanical barrier which still allowed air flow and sampling to occur, with a total of 6 replicates of each condition per year. Piglets were observed daily, with temperature of remains, stage of decomposition, weight, and any insect activity present recorded. Physical barriers successfully excluded insects for the duration of the trial, however produced a greenhouse effect, producing a total of 4500 – 6000 accumulated degree hours (ADH) during the trial while controls only reached 3000–4500ADH in the same period. Bloat phase was severely prolonged in insect exclusion replicates, and subjects did not reach the dry phase by 2700ADH across all years, compared to control piglets which all had entered dry phase by this time. When comparing percentage biomass loss, consistency in overall biomass loss was noted in control piglets, as well as insect exclusion piglets in all trials. Control piglets showed a standard deviation of 5 % biomass loss at any given ADH. Exclusion of insects reduced overall biomass loss in comparison to ADH, however trends in the rate of loss could be established within the corresponding years. This study highlights that biomass loss can occur in the absence of insect exclusion through other decomposition processes, such as bacterial interactions, and may be a useful tool in the estimation of <sub>min</sub>PMI.</div></div>","PeriodicalId":12341,"journal":{"name":"Forensic science international","volume":"367 ","pages":"Article 112389"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Point-of-care β-hydroxybutyrate and glucose as candidate screening methods for ketoacidosis-associated death in forensic autopsy investigations
IF 2.2 3区 医学 Q1 MEDICINE, LEGAL Pub Date : 2025-02-01 DOI: 10.1016/j.forsciint.2024.112358
Victoria Higgins , Matthew Nichols , Helen Jo , Rawan Alsafadi , Amber Manocchio , Paul M. Yip , Jennifer M. Dmetrichuk

Objectives

Ketone bodies, like β-hydroxybutyrate (BHB), derived from fatty acid breakdown, can cause fatal ketoacidosis if levels are excessively high. Postmortem diagnosis of ketoacidosis is challenging due to non-specificity of rapid chromogenic tests and the time required for LC-MS/MS analysis. This study investigates the feasibility of using point-of-care (POC) BHB and glucose testing to diagnose ketoacidosis-related deaths and distinguish between diabetic and other types of ketoacidosis, post-mortem.

Design and methods

This study evaluated the Nova StatStrip meter’s analytical and post-mortem performance for measuring BHB and glucose in decedent whole blood and vitreous humor. Precision, linearity, and recovery were assessed. BHB and glucose were measured in whole blood and vitreous humor from 100 autopsy cases (both ketoacidosis and non-ketoacidosis deaths). Results were compared quantitatively and qualitatively with standard laboratory methods to determine the meter's accuracy and reliability in predicting ketoacidosis-related deaths. Receiver operating characteristic (ROC) curves were constructed for each matrix/analyte combination to evaluate screening capabilities for ketoacidosis- and diabetic ketoacidosis-related deaths.

Results

Imprecision was highest in decedent vitreous humor samples for both BHB and glucose and both assays exhibited acceptable linearity. ROC curve analysis indicated comparable post-mortem performance between methods and matrices. Whole blood BHB showed the best performance for predicting all-cause ketoacidosis on the meter, despite exhibiting a higher device error messages than vitreous humor. Glucose in vitreous humor exhibited the most optimal performance (100 % sensitivity and specificity) but showed the highest rate of error messages (64 %). Thus, whole blood glucose (80 % sensitivity, 98 % specificity) would be the preferred matrix to identify potential DKA-related deaths. Agreement between meter and laboratory methods was excellent despite differing thresholds (96–100 %).

Conclusions

This study suggests that post-mortem BHB levels in whole blood and vitreous humor can be conveniently obtained using the StatStrip meter and have comparable performance to current standards, making it suitable as a screening tool for ketoacidosis-related death. Screening thresholds recommended are vitreous humor (≥ 0.9 mmol/L) or whole blood (≥ 1.6 mmol/L) BHB for ketoacidosis-related death, followed by whole blood glucose (≥ 27.3 mmol/L) for DKA-related death.
{"title":"Point-of-care β-hydroxybutyrate and glucose as candidate screening methods for ketoacidosis-associated death in forensic autopsy investigations","authors":"Victoria Higgins ,&nbsp;Matthew Nichols ,&nbsp;Helen Jo ,&nbsp;Rawan Alsafadi ,&nbsp;Amber Manocchio ,&nbsp;Paul M. Yip ,&nbsp;Jennifer M. Dmetrichuk","doi":"10.1016/j.forsciint.2024.112358","DOIUrl":"10.1016/j.forsciint.2024.112358","url":null,"abstract":"<div><h3>Objectives</h3><div>Ketone bodies, like β-hydroxybutyrate (BHB), derived from fatty acid breakdown, can cause fatal ketoacidosis if levels are excessively high. Postmortem diagnosis of ketoacidosis is challenging due to non-specificity of rapid chromogenic tests and the time required for LC-MS/MS analysis. This study investigates the feasibility of using point-of-care (POC) BHB and glucose testing to diagnose ketoacidosis-related deaths and distinguish between diabetic and other types of ketoacidosis, post-mortem.</div></div><div><h3>Design and methods</h3><div>This study evaluated the Nova StatStrip meter’s analytical and post-mortem performance for measuring BHB and glucose in decedent whole blood and vitreous humor. Precision, linearity, and recovery were assessed. BHB and glucose were measured in whole blood and vitreous humor from 100 autopsy cases (both ketoacidosis and non-ketoacidosis deaths). Results were compared quantitatively and qualitatively with standard laboratory methods to determine the meter's accuracy and reliability in predicting ketoacidosis-related deaths. Receiver operating characteristic (ROC) curves were constructed for each matrix/analyte combination to evaluate screening capabilities for ketoacidosis- and diabetic ketoacidosis-related deaths.</div></div><div><h3>Results</h3><div>Imprecision was highest in decedent vitreous humor samples for both BHB and glucose and both assays exhibited acceptable linearity. ROC curve analysis indicated comparable post-mortem performance between methods and matrices. Whole blood BHB showed the best performance for predicting all-cause ketoacidosis on the meter, despite exhibiting a higher device error messages than vitreous humor. Glucose in vitreous humor exhibited the most optimal performance (100 % sensitivity and specificity) but showed the highest rate of error messages (64 %). Thus, whole blood glucose (80 % sensitivity, 98 % specificity) would be the preferred matrix to identify potential DKA-related deaths. Agreement between meter and laboratory methods was excellent despite differing thresholds (96–100 %).</div></div><div><h3>Conclusions</h3><div>This study suggests that post-mortem BHB levels in whole blood and vitreous humor can be conveniently obtained using the StatStrip meter and have comparable performance to current standards, making it suitable as a screening tool for ketoacidosis-related death. Screening thresholds recommended are vitreous humor (≥ 0.9 mmol/L) or whole blood (≥ 1.6 mmol/L) BHB for ketoacidosis-related death, followed by whole blood glucose (≥ 27.3 mmol/L) for DKA-related death.</div></div>","PeriodicalId":12341,"journal":{"name":"Forensic science international","volume":"367 ","pages":"Article 112358"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) in forensic science – A review 飞行时间二次离子质谱法(ToF-SIMS)在法医学中的应用综述。
IF 2.2 3区 医学 Q1 MEDICINE, LEGAL Pub Date : 2025-02-01 DOI: 10.1016/j.forsciint.2024.112347
Elżbieta Maćkiewicz, Jacek Rogowski, Małgorzata Iwona Szynkowska-Jóźwik
The paper presents the possibilities of using the ToF-SIMS technique in the examination of a range of samples as forensic evidence. These include the analysis of documents, the examination of writing media, the analysis of crossing lines, the analysis of cosmetics, hair analysis, the examination of automobile paints, and the analysis of fingerprints and their contamination with exogenous substances. The advantages and disadvantages of this method were analysed with reference to the information that any forensic investigator would wish to obtain when examining highly significant evidence.
本文介绍了使用ToF-SIMS技术在一系列样品作为法医证据的检查的可能性。这些包括文件分析、书写媒介检查、交叉线分析、化妆品分析、头发分析、汽车油漆检查、指纹及其外源性物质污染分析。根据任何法医调查员在审查高度重要的证据时希望获得的信息,分析了这种方法的优点和缺点。
{"title":"Application of Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) in forensic science – A review","authors":"Elżbieta Maćkiewicz,&nbsp;Jacek Rogowski,&nbsp;Małgorzata Iwona Szynkowska-Jóźwik","doi":"10.1016/j.forsciint.2024.112347","DOIUrl":"10.1016/j.forsciint.2024.112347","url":null,"abstract":"<div><div>The paper presents the possibilities of using the ToF-SIMS technique in the examination of a range of samples as forensic evidence. These include the analysis of documents, the examination of writing media, the analysis of crossing lines, the analysis of cosmetics, hair analysis, the examination of automobile paints, and the analysis of fingerprints and their contamination with exogenous substances. The advantages and disadvantages of this method were analysed with reference to the information that any forensic investigator would wish to obtain when examining highly significant evidence.</div></div>","PeriodicalId":12341,"journal":{"name":"Forensic science international","volume":"367 ","pages":"Article 112347"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Forensic feature extraction of document paper using periodic marks: PCA and t-SNE for manufacturer discrimination and document dating 使用周期标记的文件纸的法医特征提取:PCA和t-SNE用于制造商识别和文件定年。
IF 2.2 3区 医学 Q1 MEDICINE, LEGAL Pub Date : 2025-02-01 DOI: 10.1016/j.forsciint.2024.112348
Yong Ju Lee , Chang Woo Jeong , Hyoung Jin Kim
Paper differentiation can play a critical role in forensic document examination along with examinations of handwriting identification, impressed writing, and ink and printer toner analyses. If reference database to compare was constructed, paper analyses are also useful in terms of examining when document paper was produced. In this study, two datasets were utilized for principal component analysis (PCA) and t-SNE, and each dataset was constructed for the manufacturer discrimination and document paper dating tasks. A database for the angle and step data of periodic marks at top 10 intensity respectively was established by a two dimensional lab formation sensor. Model performance was evaluated using clustering indexes, i.e., the silhouette index, the normalized mutual information, the Calinski–Harabasz index, and the Davies–Bouldin index. Periodic marks analysis using an unsupervised machine learning model was performed to differentiate the manufacturers and investigate the production date in the case of forming fabric alteration. We found that forensic differentiation of paper is feasible using a combined PCA and t-SNE model on test document data and two datasets because the forming fabric of paper-making machines inevitably leaves periodic marks on the surface of the paper. Our findings demonstrate that these periodic marks can play a key role in forensic feature extraction. As a result, the combined PCA and t-SNE model has demonstrated high performance on the target tasks.
在法证文件检验中,纸张鉴别可以与笔迹鉴定、印象文字、墨水和打印机墨粉分析一起发挥关键作用。如果建立了用于比较的参考数据库,纸张分析在检查文件纸张的生产时间方面也很有用。本研究使用了两个数据集进行主成分分析(PCA)和 t-SNE,每个数据集都是为制造商鉴别和文件纸张年代鉴定任务而构建的。通过一个二维实验室形成传感器,分别建立了前 10 个强度的周期性标记的角度和阶跃数据数据库。使用聚类指数(即轮廓指数、归一化互信息、Calinski-Harabasz 指数和 Davies-Bouldin 指数)对模型性能进行评估。使用无监督机器学习模型进行周期性标记分析,以区分制造商,并调查成形织物篡改情况下的生产日期。我们发现,由于造纸机的成形网不可避免地会在纸张表面留下周期性痕迹,因此在测试文档数据和两个数据集上使用 PCA 和 t-SNE 组合模型对纸张进行取证鉴别是可行的。我们的研究结果表明,这些周期性痕迹可在法证特征提取中发挥关键作用。因此,PCA 和 t-SNE 组合模型在目标任务中表现出了很高的性能。
{"title":"Forensic feature extraction of document paper using periodic marks: PCA and t-SNE for manufacturer discrimination and document dating","authors":"Yong Ju Lee ,&nbsp;Chang Woo Jeong ,&nbsp;Hyoung Jin Kim","doi":"10.1016/j.forsciint.2024.112348","DOIUrl":"10.1016/j.forsciint.2024.112348","url":null,"abstract":"<div><div>Paper differentiation can play a critical role in forensic document examination along with examinations of handwriting identification, impressed writing, and ink and printer toner analyses. If reference database to compare was constructed, paper analyses are also useful in terms of examining when document paper was produced. In this study, two datasets were utilized for principal component analysis (PCA) and t-SNE, and each dataset was constructed for the manufacturer discrimination and document paper dating tasks. A database for the angle and step data of periodic marks at top 10 intensity respectively was established by a two dimensional lab formation sensor. Model performance was evaluated using clustering indexes, i.e., the silhouette index, the normalized mutual information, the Calinski–Harabasz index, and the Davies–Bouldin index. Periodic marks analysis using an unsupervised machine learning model was performed to differentiate the manufacturers and investigate the production date in the case of forming fabric alteration. We found that forensic differentiation of paper is feasible using a combined PCA and t-SNE model on test document data and two datasets because the forming fabric of paper-making machines inevitably leaves periodic marks on the surface of the paper. Our findings demonstrate that these periodic marks can play a key role in forensic feature extraction. As a result, the combined PCA and t-SNE model has demonstrated high performance on the target tasks.</div></div>","PeriodicalId":12341,"journal":{"name":"Forensic science international","volume":"367 ","pages":"Article 112348"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Estimating illicit production of MDMA from its production waste, a Dutch case study 从生产废物中估算亚甲二氧基甲基苯丙胺的非法产量,荷兰案例研究。
IF 2.2 3区 医学 Q1 MEDICINE, LEGAL Pub Date : 2025-02-01 DOI: 10.1016/j.forsciint.2024.112315
Thomas L. ter Laak , Jorrit van den Berg , Erik Emke , Shanna Mehlbaum , Pim de Voogt
The Netherlands plays a key role in the global production of the synthetic illicit drug MDMA. However, the actual Dutch production of MDMA is difficult to quantify. The illicit production of MDMA results in large amounts of waste. This study uses amounts of waste found in the environment and production-related MDMA residues in wastewater to estimate the amount of MDMA that is produced. The MDMA produced, associated to the amount of waste found in the environment is 4.2 and 5.8 tons per year for two common synthesis routes. The MDMA produced, associated to production-related residues in wastewater is significantly larger, with 39.2 tons per year. The estimated MDMA production associated to waste in the environment and wastewater analysis is 43.4 and 45.0 tons per year for two common synthesis routes. Even though these estimates are difficult to validate, they are feasible when compared to prevalence-based consumption estimates or production estimates based on interceptions of precursors. The current study illustrates that waste of an illicit industry can shed light on its production volumes, thereby, complementing other efforts to estimate production, trade and use of synthetically produced illicit substances.
荷兰在全球合成非法药物亚甲二氧基甲基苯丙胺的生产中发挥着关键作用。然而,荷兰亚甲二氧基甲基苯丙胺的实际产量很难量化。亚甲二氧基甲基苯丙胺的非法生产会产生大量废物。本研究利用在环境中发现的废物量和废水中与生产有关的亚甲二氧基甲基苯丙胺残留量来估算亚甲二氧基甲基苯丙胺的产量。对于两种常见的合成路线,与环境中发现的废物量相关的亚甲二氧基甲基苯丙胺产量分别为每年 4.2 吨和 5.8 吨。与废水中与生产相关的残留物有关的亚甲二氧基甲基苯丙胺产量要大得多,每年达 39.2 吨。对两种常见合成路线进行分析后,与环境中的废物和废水相关的亚甲二氧基甲基苯丙胺产量估计分别为每年 43.4 吨和 45.0 吨。尽管这些估算难以验证,但与基于流行率的消费量估算或基于前体截获量的产量估算相比,还是可行的。目前的研究表明,非法产业的废物可以揭示其生产量,从而补充其他估算合成非法物质的生产、贸易和使用的工作。
{"title":"Estimating illicit production of MDMA from its production waste, a Dutch case study","authors":"Thomas L. ter Laak ,&nbsp;Jorrit van den Berg ,&nbsp;Erik Emke ,&nbsp;Shanna Mehlbaum ,&nbsp;Pim de Voogt","doi":"10.1016/j.forsciint.2024.112315","DOIUrl":"10.1016/j.forsciint.2024.112315","url":null,"abstract":"<div><div>The Netherlands plays a key role in the global production of the synthetic illicit drug MDMA. However, the actual Dutch production of MDMA is difficult to quantify. The illicit production of MDMA results in large amounts of waste. This study uses amounts of waste found in the environment and production-related MDMA residues in wastewater to estimate the amount of MDMA that is produced. The MDMA produced, associated to the amount of waste found in the environment is 4.2 and 5.8 tons per year for two common synthesis routes. The MDMA produced, associated to production-related residues in wastewater is significantly larger, with 39.2 tons per year. The estimated MDMA production associated to waste in the environment and wastewater analysis is 43.4 and 45.0 tons per year for two common synthesis routes. Even though these estimates are difficult to validate, they are feasible when compared to prevalence-based consumption estimates or production estimates based on interceptions of precursors. The current study illustrates that waste of an illicit industry can shed light on its production volumes, thereby, complementing other efforts to estimate production, trade and use of synthetically produced illicit substances.</div></div>","PeriodicalId":12341,"journal":{"name":"Forensic science international","volume":"367 ","pages":"Article 112315"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Forensic science international
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1