Food Hydrocolloids for Health最新文献_第2页

Enhanced oral delivery of zeaxanthin via chitosan/alginate nanoparticles: Optimizing stability and antioxidant efficacy in retinal cells 壳聚糖/海藻酸盐纳米颗粒增强玉米黄质口服递送：优化视网膜细胞的稳定性和抗氧化功效

IF 5.1 Q1 CHEMISTRY, APPLIED

Food Hydrocolloids for Health

Pub Date : 2025-12-01 DOI: 10.1016/j.fhfh.2025.100254

Feuangthit Niyamissara Sorasitthiyanukarn , Chawanphat Muangnoi , Nonthaneth Nalinratana , Pranee Rojsitthisak , Pornchai Rojsitthisak

Zeaxanthin (ZT), a lipophilic carotenoid with strong antioxidant potential, suffers from poor aqueous solubility and low oral bioavailability, which limits its therapeutic application. In this study, chitosan/alginate nanoparticles (CS/ALG-NPs) were developed and optimized for oral ZT delivery using a Box-Behnken design. The optimized NPs showed a particle size of 268 ± 35 nm, a zeta potential of −25.2 ± 0.8 mV, and an encapsulation efficiency of 75.4 ± 3.4%. In vitro release under simulated gastrointestinal (GI) conditions exhibited sustained release with improved digestive stability and bioaccessibility compared to free ZT. The optimized ZT-CS/ALG-NPs exhibited favorable stability, maintaining particle size, surface charge, and encapsulation efficiency during storage at 4 °C, and retained their spherical morphology and uniform dispersion after simulated GI digestion, supporting their potential for oral delivery applications. In ARPE-19 cells, ZT-CS/ALG-NPs significantly reduced intracellular reactive oxygen species, restored antioxidant enzyme activities (SOD, CAT, GPx), and increased intracellular glutathione (GSH) levels compared to free ZT. Under H₂O₂-induced oxidative stress, ZT-CS/ALG-NPs reduced the expression of pro-apoptotic proteins (Bax and cytochrome c) and increased the expression of anti-apoptotic protein (Bcl-2) in ARPE-19 cells (vs H₂O₂ group). Transmission electron microscopy and flow cytometry confirmed cellular uptake. These findings demonstrate the potential of CS/ALG-NPs as a polysaccharide-based oral delivery system to enhance the stability, bioaccessibility, and antioxidant efficacy of hydrophobic bioactives such as zeaxanthin.

玉米黄质（ZT）是一种亲脂性类胡萝卜素，具有较强的抗氧化潜力，但其水溶性差，口服生物利用度低，限制了其治疗应用。在这项研究中，壳聚糖/海藻酸盐纳米颗粒（CS/ALG-NPs）被开发和优化，用于口服ZT。优化后的NPs粒径为268±35 nm， zeta电位为−25.2±0.8 mV，包封效率为75.4±3.4%。与游离ZT相比，在模拟胃肠道（GI）条件下的体外释放表现出持续释放，并改善了消化稳定性和生物可及性。优化后的ZT-CS/ alg - np具有良好的稳定性，在4°C储存期间保持了粒径、表面电荷和包封效率，并且在模拟胃肠道消化后保持了其球形形态和均匀分散，支持其口服给药应用的潜力。在ARPE-19细胞中，与游离ZT相比，ZT- cs /ALG-NPs显著降低细胞内活性氧，恢复抗氧化酶活性（SOD、CAT、GPx），增加细胞内谷胱甘肽（GSH）水平。在H2O2诱导的氧化应激下，ZT-CS/ALG-NPs降低了ARPE-19细胞中促凋亡蛋白（Bax和细胞色素c）的表达，增加了抗凋亡蛋白（Bcl-2）的表达（与H2O2组相比）。透射电镜和流式细胞术证实细胞摄取。这些发现表明，CS/ALG-NPs作为一种基于多糖的口服给药系统，具有增强玉米黄质等疏水生物活性物质的稳定性、生物可及性和抗氧化功效的潜力。

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引用次数: 0

Exploring the prebiotic potential of dietary fibre concentrates from artichoke, red pepper, cucumber, and carrot by-products 探索从朝鲜蓟、红辣椒、黄瓜和胡萝卜副产品中提取的膳食纤维浓缩物的益生元潜力

IF 5.1 Q1 CHEMISTRY, APPLIED

Food Hydrocolloids for Health

Pub Date : 2025-12-01 DOI: 10.1016/j.fhfh.2025.100257

Ana A. Vaz , Isabel Odriozola-Serrano , Gemma Oms-Oliu , Olga Martín-Belloso , Gemma Bellí

The agri-food industry exerts a considerable environmental impact while contributing to substantial losses of functional nutrients, particularly dietary fibre. Developing dietary fibre concentrates (DFCs) as novel functional food ingredients offers a dual opportunity: reducing environmental impact and delivering health-promoting prebiotic ingredients. This study evaluated the prebiotic potential of DFCs from artichoke, carrot, cucumber, and red pepper by assessing their impact on targeted gut microbiota composition and short-chain fatty acid (SCFA) production during 48 h of in vitro colonic digestion.

All DFCs reduced the Firmicutes/Bacteroidetes ratio from 0.5 to 0.8 at 24 h to below 0.4 at 48 h, indicating shifts towards microbial profiles favoring fibre degradation. Artichoke DFC induced the most pronounced effect, markedly stimulating Lactobacillus populations (>100-fold at 24 h and 14-fold increase at 48 h), likely linked to its chlorogenic acid and inulin content. Carrot DFC also promoted Lactobacillus spp. growth at 24 h, while both artichoke and carrot DFCs enhanced Bifidobacterium abundance. SCFA analysis revealed acetic acid as the dominant metabolite, with peak concentrations in cucumber (35.85 mM), red pepper (32.18 mM), and carrot (22.85 mM) fermentations at 48 h. Remarkably, artichoke DFC yielded the highest butyric acid concentration (13.30 mM), a key metabolite for colonocyte energy supply and intestinal barrier integrity.

These findings establish vegetable-derived DFCs, particularly artichoke and carrot, as promising prebiotic ingredients that can be selectively utilised by microorganisms to confer health benefits, while also highlighting a sustainable strategy to transform agricultural by-products into valuable functional foods ingredients with possible impacts on gut health.

农业食品工业对环境造成相当大的影响，同时造成功能性营养素，特别是膳食纤维的大量损失。开发膳食纤维浓缩物（dfc）作为新型功能性食品成分提供了双重机会：减少对环境的影响并提供促进健康的益生元成分。本研究通过评估朝鲜蓟、胡萝卜、黄瓜和红辣椒中dfc在48 h体外结肠消化过程中对目标肠道菌群组成和短链脂肪酸（SCFA）产生的影响，评估了dfc的益生元潜力。所有的dfc都将厚壁菌门/拟杆菌门的比值从24小时的0.5 - 0.8降低到48小时的0.4以下，这表明微生物分布向有利于纤维降解的方向转变。洋蓟DFC诱导的效果最为显著，显著刺激乳酸菌数量（24小时增加100倍，48小时增加14倍），可能与其绿原酸和菊粉含量有关。胡萝卜DFC还能促进乳酸菌在24 h的生长，而朝鲜蓟和胡萝卜DFC均能提高双歧杆菌的丰度。SCFA分析显示乙酸是主要代谢物，在48 h时，黄瓜（35.85 mM）、红辣椒（32.18 mM）和胡萝卜（22.85 mM）的发酵浓度达到峰值。值得注意的是，朝鲜蓟DFC产生的丁酸浓度最高（13.30 mM），这是结肠细胞能量供应和肠道屏障完整性的关键代谢物。这些发现证实了蔬菜衍生的无营养食品，特别是洋蓟和胡萝卜，是有前途的益生元成分，微生物可以选择性地利用它们来带来健康益处，同时也强调了将农业副产品转化为可能对肠道健康产生影响的有价值的功能性食品成分的可持续战略。

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引用次数: 0

Topical nanogel of glutathione and coenzyme Q10 in sodium alginate for chronic and inflammatory skin conditions: A synergistic antioxidant and anti-inflammatory delivery platform 外用海藻酸钠谷胱甘肽和辅酶Q10纳米凝胶治疗慢性和炎症性皮肤疾病：一种协同抗氧化和抗炎的递送平台

IF 5.1 Q1 CHEMISTRY, APPLIED

Food Hydrocolloids for Health

Pub Date : 2025-12-01 DOI: 10.1016/j.fhfh.2025.100258

Samaa Abdullah , Samar Thiab , Alaa A. Al-Masud , Sarah Fahmi Faludah , Abeer A. Altamimi

Background

Chronic wounds and oxidative stress–related skin disorders, such as diabetic ulcers, burns, surgical wounds, and inflammatory dermatoses, require sustained topical delivery of antioxidant and anti-inflammatory agents. Glutathione (GSH) and Coenzyme Q10 (CoQ10) offer synergistic therapeutic effects but suffer from poor stability and limited skin permeability. This study developed and evaluated a sodium alginate (SA)-based nanogel co-delivering GSH and CoQ10 for enhanced wound healing.

Methods

A GSH–CoQ10 complex was prepared via adsorption and characterised using FT-IR, DSC, XRD, and SEM. The complex was incorporated into SA gels at varying concentrations (1.5%, 2.5%, 3.5%), and formulations were analysed for particle size, polydispersity index (PDI), and zeta potential using dynamic light scattering. GSH release was measured using a DTNB assay and fitted to kinetic models. Rheological behaviour, long-term stability (12 months), and morphology (SEM/TEM) were examined. In vivo efficacy was tested in a rat excisional wound model (n = 36), with ELISA quantification of VEGF, TGF-β1, Collagen I, and IL-6.

Results

The optimal 2.5% SA nanogel exhibited 122.0 ± 4.9 nm particle size, −40.0 ± 1.3 mV zeta potential, and PDI 0.25 ± 0.02. GSH release reached 72% over 24 h, following Korsmeyer–Peppas kinetics. Rheological analysis indicated pseudoplastic behaviour. The formulation remained stable for 12 months (f₂ = 81.04). In vivo, the nanogel achieved 98.6% wound closure at day 14 and significantly improved collagen synthesis while reducing IL-6 levels.

Conclusion

The GSH–CoQ10-loaded SA nanogel offers a stable and effective platform for treating chronic and acute skin injuries through synergistic antioxidant and anti-inflammatory mechanisms.

慢性伤口和氧化应激相关的皮肤疾病，如糖尿病性溃疡、烧伤、外科伤口和炎症性皮肤病，需要持续的局部递送抗氧化剂和抗炎药。谷胱甘肽（GSH）和辅酶Q10 （CoQ10）具有协同治疗作用，但稳定性差，皮肤渗透性有限。本研究开发并评估了海藻酸钠（SA）纳米凝胶共同递送谷胱甘肽和辅酶q10以促进伤口愈合。方法采用吸附法制备GSH-CoQ10配合物，并用FT-IR、DSC、XRD、SEM对其进行表征。将该配合物以不同浓度（1.5%、2.5%、3.5%）掺入SA凝胶中，并利用动态光散射分析配方的粒径、多分散性指数（PDI）和zeta电位。用DTNB法测定谷胱甘肽释放量，并拟合动力学模型。流变行为、长期稳定性（12个月）和形貌（SEM/TEM）进行了检测。在大鼠切除伤口模型（n = 36）中检测其体内疗效，ELISA定量VEGF、TGF-β1、Collagen I和IL-6。结果优选的2.5% SA纳米凝胶粒径为122.0±4.9 nm， zeta电位为- 40.0±1.3 mV， PDI为0.25±0.02。GSH在24小时内释放达到72%，遵循Korsmeyer-Peppas动力学。流变分析表明其具有假塑性行为。配方保持稳定12个月（f₂= 81.04）。在体内，纳米凝胶在第14天达到98.6%的伤口愈合，并显著改善胶原合成，同时降低IL-6水平。结论负载gsh - coq10的SA纳米凝胶通过协同抗氧化和抗炎机制，为治疗慢性和急性皮肤损伤提供了稳定有效的平台。

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引用次数: 0

Hypoglycemic effect of W/O/W emulsion encapsulating Polygonatum sibiricum polysaccharides and saponins in a mouse model of T2DM 包埋黄精多糖和皂苷的W/O/W乳剂对T2DM小鼠模型的降糖作用

IF 5.1 Q1 CHEMISTRY, APPLIED

Food Hydrocolloids for Health

Pub Date : 2025-11-29 DOI: 10.1016/j.fhfh.2025.100259

Mi Li , Yunge Zhang , Quanlin Li , Bingzong Xie , Jian Ju , Yanli Ma

This study explores the hypoglycemic efficacy of W/O/W emulsion co-encapsulating Polygonatum sibiricum polysaccharides (PSP) and saponins (PSS). In streptozotocin/high-fat diet-induced type 2 diabetes mellitus (T2DM) mice, the encapsulated PSP/PSS exhibited excellent activity: reversing typical "three more and one less" symptoms, and significantly improving blood glucose, glucose tolerance, insulin resistance, lipids, liver oxidative stress, liver glycogen, and liver/kidney morphology. After 4 weeks of intervention, the fasting blood glucose (FBG) reduction rate of the co-encapsulation group (PPE) was 20%, the homeostasis model assessment of insulin resistance (HOMA-IR) decreased by 35%, and the hepatic glycogen content increased by 122%. Meanwhile, PSP/PSS exerted effects by regulating intestinal beneficial microbiota, Akkermansia and Lactobacillus abundances in the PPE group were 1.8-fold and 2.3-fold higher than those in the diabetic model group (DC), respectively, which was more significant than the microbial regulatory effect of the PSP-only emulsion group (PE). Compared with PE group, the co-encapsulation system showed more prominent efficacy, highlighting multi-component synergistic delivery advantages. This study first confirms that W/O/W emulsion-based PSP/PSS delivery system effectively improves diabetic pathology, providing an innovative paradigm for integrating novel functional food delivery technologies with traditional medicine-food homologous plants.

本研究探讨了黄精多糖（PSP）和皂苷（PSS）共包埋W/O/W乳液的降糖效果。在链脲佐菌素/高脂饮食诱导的2型糖尿病（T2DM）小鼠中，包封的PSP/PSS表现出优异的活性：逆转典型的“三多一少”症状，显著改善血糖、葡萄糖耐量、胰岛素抵抗、血脂、肝脏氧化应激、肝糖原和肝肾形态。干预4周后，共胶囊组（PPE）空腹血糖（FBG）降低率为20%，胰岛素抵抗稳态模型评估（HOMA-IR）降低35%，肝糖原含量升高122%。同时，PSP/PSS通过调节肠道有益菌群发挥作用，PPE组的Akkermansia和Lactobacillus丰度分别比糖尿病模型组（DC）高1.8倍和2.3倍，比仅PSP乳状液组（PE）的微生物调节作用更为显著。与PE组相比，共胶囊体系的功效更加突出，突出了多组分协同递送的优势。本研究首次证实了W/O/W乳化液为基础的PSP/PSS给药系统能有效改善糖尿病病理，为将新型功能性食品给药技术与传统药食同源植物相结合提供了创新范例。

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引用次数: 0

Development of a new self-nanoemulsifying Narcissus tazetta L. oil delivery system and study of its anti-breast and anti-pancreas cancers activities in vitro 新型自纳米乳化水仙油传递体系的研制及其体外抗乳腺癌、抗胰腺癌活性研究

IF 5.1 Q1 CHEMISTRY, APPLIED

Food Hydrocolloids for Health

Pub Date : 2025-11-14 DOI: 10.1016/j.fhfh.2025.100255

R. Nazari-Vanani , S.R. Rasouli Nasrabadi , S.A. Dastgheib , H. Heli

Administration of natural oil extracts suffers from low oral bioavailability and anti-proliferative activity. Self-nanoemulsifying drug delivery systems (SNEDDSs) are novel formulations to improvement of the efficacy of poorly water-soluble compounds. In this study, a novel Narcissus Tazetta L. oil-loaded SNEDDS (NT-SNEDDS) was used to improve the antitumor effect of the oil against MCF-7 and PANC-1 cells. 30% tween 80, 55 % PEG 600, and 15 % ethyl oleate were considered as surfactant, cosurfactant, and oil, respectively, to form a SNEDDS. When combined with water, NT-SNEDDS created a nanoemulsion consisting of oil nanodroplets of 40±8 nm. Field emission scanning electron microscopy was also utilized to examine the structure of the nanodroplets. The formulations exhibited no indications of precipitation or phase separation throughout the storage duration. Toxicity of NT-SNEDDS was evaluated, and the results suggested that it had potential as an anticancer with IC50 values of 0.17 and 0.21 % (V/V, Narcissus Tazetta L. oil content of NT-SNEDDS) against MCF-7 and PANC-1 cells, respectively. The enhanced cytotoxicity was due to the induction of DNA fragmentation and apoptosis. Further investigations through in vitro mechanistic endpoint as well as in vivo experimentations would clarify the efficacy of NT-SNEDDS.

天然油提取物的口服生物利用度和抗增殖活性较低。自纳米乳化给药系统（snedds）是一种改善难水溶性化合物药效的新剂型。本研究利用一种新型水仙油负载SNEDDS （NT-SNEDDS）提高水仙油对MCF-7和PANC-1细胞的抗肿瘤作用。将30%的二甲苯80、55%的PEG 600和15%的油酸乙酯分别作为表面活性剂、助表面活性剂和油，形成SNEDDS。当与水结合时，NT-SNEDDS形成了由40±8 nm的油纳米滴组成的纳米乳液。利用场发射扫描电镜对纳米液滴的结构进行了表征。在整个贮存期间，制剂没有表现出沉淀或相分离的迹象。结果表明，NT-SNEDDS对MCF-7和PANC-1细胞的IC50值分别为0.17和0.21% （V/V，水仙油含量）。细胞毒性的增强是由于DNA断裂和细胞凋亡的诱导。通过体外机制终点和体内实验的进一步研究将阐明NT-SNEDDS的疗效。

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引用次数: 0

Encapsulation of bifidobacteria in natural biopolymers: Advances, challenges, and applications in dairy products 双歧杆菌在天然生物聚合物中的包封：进展、挑战和在乳制品中的应用

IF 5.1 Q1 CHEMISTRY, APPLIED

Food Hydrocolloids for Health

Pub Date : 2025-11-04 DOI: 10.1016/j.fhfh.2025.100252

Marko Vinceković , Lana Živković , Botagoz Mutaliyeva , Galiya Madybekova , Elmira Turkeyeva , Nenad Jalšenjak , Assem Issayeva

Encapsulation of Bifidobacteria with natural biopolymers has emerged as a promising strategy to enhance the viability of probiotics in dairy systems. While Bifidobacteria confer well-established health benefits, their industrial application is hindered by sensitivity to processing and storage conditions. This review critically evaluates encapsulation methods, including extrusion, emulsification, spray drying, and freeze drying, as well as natural polymers such as alginate, chitosan, carrageenan, gelatin, and starch, with a focus on their ability to maintain the stability of probiotics. Beyond summarizing current techniques, we highlight persisting gaps in scalability, cost efficiency, and consumer acceptance, issues often overlooked in earlier reviews. By integrating recent advances in material science with food engineering perspectives, this article outlines pathways for industrial translation. It distinguishes itself by focusing on how encapsulation strategies can be optimized to overcome these barriers, ultimately enabling broader adoption of probiotic-enriched dairy products.

用天然生物聚合物封装双歧杆菌已成为一种有前途的策略，以提高益生菌在乳制品系统中的生存能力。虽然双歧杆菌具有公认的健康益处，但它们对加工和储存条件的敏感性阻碍了它们的工业应用。本文综述了包括挤压、乳化、喷雾干燥和冷冻干燥在内的封装方法，以及海藻酸盐、壳聚糖、卡拉胶、明胶和淀粉等天然聚合物，重点介绍了它们保持益生菌稳定性的能力。除了总结当前的技术之外，我们还强调了在可伸缩性、成本效率和消费者接受度方面持续存在的差距，这些问题在早期的评论中经常被忽视。通过将材料科学的最新进展与食品工程观点相结合，本文概述了工业翻译的途径。它的特点是专注于如何优化封装策略来克服这些障碍，最终使益生菌丰富的乳制品得到更广泛的采用。

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引用次数: 0

Topical fish scale collagen cream: Formulation, skin permeation, and biocompatibility for cosmetic and therapeutic use 外用鱼鳞胶原蛋白霜：化妆品和治疗用的配方、皮肤渗透性和生物相容性

IF 5.1 Q1 CHEMISTRY, APPLIED

Food Hydrocolloids for Health

Pub Date : 2025-11-03 DOI: 10.1016/j.fhfh.2025.100253

Ismail Zainol , Ayah Rebhi Hilles , Wan Rusmawati Wan Mahamod , Hasnor Izzati Che Razali , Haniza Hanim Mohd Zain

This study aims to develop and characterise fish scale-collagen cream (CoC) intended for topical application. The development of CoC consists of hydrolysed collagen (molecular weight ≈ 1 kDa) dispersed into the aqueous phase of a water-in-oil (w/o) emulsion of Span 60: Tween 60/water/virgin coconut oil (VCO) system. Collagen used in this study has been extracted from Tilapia fish scales using hydrothermal extraction combined with enzymatic hydrolysis treatment. The CoC was developed using a water-in-VCO emulsion medium at water volume fractions (φ_w) of 0.74, 0.83, and 0.94. Up to 20 wt.% of hydrolysed collagen was successfully loaded into the emulsion system via the high shear homogenisation technique. The characterisation of the CoC involved a complex microscopic analysis, including optical polarising microscopy (OPM) and scanning electron microscopy (SEM), complemented by droplet size analysis, differential scanning calorimetry, and rheological evaluation. The physical characteristics of CoC were investigated to evaluate its suitability for administration on the skin. The potential of CoC to be applied on the skin was evaluated using analysis of ex vivo rat skin permeation using the Franz diffusion cell, in vitro fibroblast cell viability and in vivo toxicity to the mice. Franz diffusion cell studies revealed 3466.46 ± 21.70 μg/cm² cumulative collagen permeation over 6 h (vs. 1750 ± 319.67 μg/cm² control; p < 0.001, 95 % CI: 1580–1850 μg/cm²), with 94–97 % retention in skin layers. In vitro, 0.02 mg/mL hydrolysed collagen increased fibroblast viability by 34 % (p < 0.01, n = 3). Furthermore, Sub-acute toxicity tests of 25–50 mg/kg body weight of hydrolysed collagen for 7 days showed no significant weight changes (p > 0.05, 95 % CI: −0.5 % to +1.2 %) or mortality. It was observed that the hydrolysed collagen could pass through the rat skin easily and successfully stimulate the fibroblast cell viability. In conclusion, CoC is a suitable carrier for hydrolysed collagen in topical applications. The use of the designed emulsion-based creams can safely enhance the delivery of the hydrolysed collagen in the skin layers with additional benefits for cosmetic and therapeutic applications.

本研究旨在开发和表征用于外用的鱼鳞胶原蛋白霜（CoC）。CoC的制备由水解的胶原蛋白（分子量≈1 kDa）分散在Span 60: Tween 60/水/初榨椰子油（VCO）体系的油包水（w/o）乳液的水相中组成。本研究使用的胶原蛋白是从罗非鱼鱼鳞中提取的，采用水热萃取结合酶解处理。CoC是在水体积分数（φw）分别为0.74、0.83和0.94的水- vco乳液介质中制备的。通过高剪切均质技术，高达20%的水解胶原蛋白被成功地装入乳液系统。CoC的表征涉及复杂的显微分析，包括光学偏光显微镜（OPM）和扫描电子显微镜（SEM），辅以液滴尺寸分析、差示扫描量热法和流变学评估。研究了CoC的物理特性，以评价其在皮肤上给药的适用性。利用Franz扩散细胞分析体外大鼠皮肤渗透性、体外成纤维细胞活力和对小鼠的体内毒性，评估CoC在皮肤上的应用潜力。Franz扩散池研究显示，6小时内累积胶原渗透3466.46±21.70 μg/cm²（对照组为1750±319.67 μg/cm²；p < 0.001, 95% CI: 1580-1850 μg/cm²），在皮肤层中保留率为94 - 97%。在体外，0.02 mg/mL水解胶原可使成纤维细胞活力提高34% （p < 0.01, n = 3）。此外，25-50 mg/kg体重水解胶原蛋白7天的亚急性毒性试验显示，体重没有显著变化（p > 0.05, 95% CI: - 0.5%至+ 1.2%）或死亡率。结果表明，水解后的胶原蛋白能很容易地穿过大鼠皮肤，并能成功地刺激成纤维细胞的活力。综上所述，CoC是一种适合于外用的水解胶原蛋白载体。使用设计的乳化乳霜可以安全地增强皮肤层中水解胶原蛋白的输送，并为美容和治疗应用带来额外的好处。

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引用次数: 0

Advances and innovative applications of persian gum as a native hydrocolloid: Physicochemical properties, biopolymer compatibility, and encapsulation technologies 作为天然水胶体的波斯胶的进展和创新应用：物理化学性质、生物聚合物相容性和封装技术

IF 5.1 Q1 CHEMISTRY, APPLIED

Food Hydrocolloids for Health

Pub Date : 2025-10-24 DOI: 10.1016/j.fhfh.2025.100250

Zahra Khoshdouni Farahani , Mohammad ali Ebrahimzadeh Mousavi , Abdorreza Mohammadi Nafchi

This mini review focuses on Persian gum, a native Iranian hydrocolloid derived from the mountain almond tree (Amygdalus species), which has attracted significant interest due to its unique structural properties and potential applications across various industries, especially in food and pharmaceuticals. Despite its promising characteristics, the use of Persian gum in coating and encapsulation technologies within the food industry remains limited. This paper highlights recent advances in the development of Persian gum-based beads and capsules for encapsulation purposes. Utilizing this native gum as a cost-effective coating material not only offers a sustainable alternative to expensive imported hydrocolloids but also provides comparable quality in food formulations. Moreover, Persian gum demonstrates excellent compatibility with other biopolymers and proteins, broadening its potential applications. The review summarizes experimental findings on Persian gum’s encapsulation efficiency, interactions with other gums and proteins, and its role in various coating methods. These insights underscore Persian gum’s promising role as a versatile and economical encapsulating agent, with significant potential for broader industrial application.

这篇综述主要介绍了波斯胶，一种源自山杏仁树的伊朗原生水胶体，由于其独特的结构特性和在各个行业，特别是食品和制药领域的潜在应用，引起了人们的极大兴趣。尽管具有很好的特性，波斯胶在食品工业的涂层和封装技术中的应用仍然有限。本文重点介绍了用于封装目的的波斯胶基珠和胶囊的最新进展。利用这种天然胶作为一种具有成本效益的涂层材料，不仅为昂贵的进口水胶体提供了可持续的替代品，而且在食品配方中也提供了相当的质量。此外，波斯胶与其他生物聚合物和蛋白质具有良好的相容性，扩大了其潜在的应用范围。综述了波斯胶的包封效率、与其它树胶和蛋白质的相互作用以及在各种包封方法中的作用。这些见解强调了波斯胶作为一种多功能和经济的包封剂的前景，具有更广泛的工业应用潜力。

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引用次数: 0

Advances in food-grade hydrogel encapsulation of probiotics with next-generation prebiotics for targeted synbiotic delivery 新一代益生元靶向合成给药的食品级水凝胶包封益生菌研究进展

IF 5.1 Q1 CHEMISTRY, APPLIED

Food Hydrocolloids for Health

Pub Date : 2025-10-23 DOI: 10.1016/j.fhfh.2025.100251

Vidmantė Minelgaitė, Sigita Jeznienė, Aušra Šipailienė

Background. Hydrogel-based encapsulation represents a successful method for preserving probiotics and their functionality during processing, storage, and gastrointestinal transit. Although conventional systems offer protection, advances in next-generation prebiotics such as polyphenols and non-digestible carbohydrates have shifted the focus toward multifunctional synbiotic delivery systems. These materials provide sustainable, food-grade design and improve both structural integrity and bioactivity. Additionally, fabrication and crosslinking methods such as ionic interactions, Maillard conjugation, and enzymatic or pH-responsive techniques facilitate precise hydrogel customization for targeted probiotic release. Scope and approach. This review discusses recent progress in natural and composite hydrogels for probiotic encapsulation, with particular attention to the influence of next generation prebiotics on hydrogel functionality. A decision-oriented design framework is presented, aligning target sites and release triggers with materials and crosslinking strategies, exemplified with quantitative results. This framework offers a systematic approach for selecting food-grade matrices and encapsulation methods. Key findings and conclusions. Natural and composite hydrogels provide effective protection against oxygen, heat, acidity, bile salts, and digestive enzymes, maintaining a hydrated and biocompatible microenvironment. Protein–polysaccharide combinations increase mechanical and rheological stability, while next-generation prebiotics further reinforce structural integrity and bioactivity. Encapsulation efficiencies above 90 percent and enhanced cell viability in simulated digestion demonstrate promising performance of these systems. The integration of quantitative mapping and design principles establishes a practical framework for developing scalable, food-grade, multifunctional synbiotic hydrogels, supporting advancements in probiotic delivery technology. Adopting standardized digestion models and prioritizing in vivo validation will aid the development of synbiotic hydrogels acceptable in real food systems.

背景。水凝胶包封是一种在加工、储存和胃肠道运输过程中保存益生菌及其功能的成功方法。虽然传统的系统提供保护，新一代益生元如多酚和不可消化的碳水化合物的进步已经将重点转移到多功能合成输送系统。这些材料提供了可持续的食品级设计，并提高了结构完整性和生物活性。此外，制造和交联方法，如离子相互作用、美拉德偶联、酶或ph响应技术，有助于精确定制靶向益生菌释放的水凝胶。范围和方法。本文综述了用于益生菌包封的天然和复合水凝胶的最新进展，特别关注了下一代益生元对水凝胶功能的影响。提出了一个决策导向的设计框架，将目标地点和释放触发器与材料和交联策略对齐，并以定量结果为例。该框架为选择食品级基质和封装方法提供了系统的方法。主要发现和结论。天然和复合水凝胶提供有效的保护，防止氧气，热量，酸性，胆汁盐和消化酶，维持一个水合和生物相容性的微环境。蛋白质-多糖组合增加了机械和流变稳定性，而下一代益生元进一步增强了结构完整性和生物活性。90%以上的封装效率和在模拟消化中增强的细胞活力证明了这些系统的良好性能。定量制图和设计原则的整合为开发可扩展的食品级多功能合成水凝胶建立了一个实用框架，支持益生菌输送技术的进步。采用标准化的消化模型和优先进行体内验证将有助于开发在实际食物系统中可接受的合成水凝胶。

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引用次数: 0

Characterization and physicochemical properties of a novel microencapsulated bio-calcium from Asian sea bass bones 新型微囊生物钙的制备及理化性质研究

IF 5.1 Q1 CHEMISTRY, APPLIED

Food Hydrocolloids for Health

Pub Date : 2025-10-11 DOI: 10.1016/j.fhfh.2025.100247

Salinee Phengleng , Wipavadee Sangadkit , Songsak Wattanachaisaereekul , Jiraporn Sirison , Suneerat Ruangsomboon

Calcium is the most abundant mineral in the human body, yet intake remains insufficient in many populations. Fishbone-derived bio-calcium from Asian sea bass (Lates calcarifer), containing approximately 37.5 % calcium (dry weight), offers a cost-effective source. However, its primary form, hydroxyapatite, has low solubility due to high crystallinity, limiting its application in food fortification. This study aimed to enhance the physicochemical properties of bio-calcium (B) powders by encapsulating them with maltodextrin (M), gum arabic (G), and their combination (MG) at 5 %, 10 %, and 15 % (w/v) using spray drying. A 1:4 (w/w) ratio of B to wall materials was applied at 180 °C (inlet) and 60 °C (outlet) temperatures. Powder yields ranged from 25.2 % (15 % BG) to 30.3 % (15 % BM), with no significant differences (p > 0.05) among treatments. Encapsulated powders had higher lightness (L*) than B. The highest calcium content and encapsulation efficiency were observed in 5 % BG, while BM showed the lowest. Moisture content and water activity remained below 10 % and 0.6 %, respectively. BG had the highest hygroscopicity, while wall concentration had no significant (p > 0.05) impact. Encapsulation improved water solubility index (75.4–86.5 %), especially in BM. Particle sizes ranged from 0.92 µm (10 % BMG) to 2.89 µm (15 % BM), while zeta potentials ranged from -8.71 mV (15 % BM) to -20.90 mV (15 % BMG). Encapsulated powders were more spherical and smoother than B, while BG particles showed aggregation, whereas BMG showed mixed morphologies. These findings suggest that encapsulation enhanced the physicochemical properties of bio-calcium, supporting its potential application in calcium-fortified foods and dietary supplements.

钙是人体内最丰富的矿物质，但许多人的摄入量仍然不足。从亚洲黑鲈（Lates calcarifer）中提取的鱼骨生物钙含有约37.5%的钙（干重），是一种具有成本效益的来源。然而，其主要形式羟基磷灰石由于结晶度高，溶解度低，限制了其在食品强化中的应用。以5%、10%和15% （w/v）浓度的麦芽糖糊精(M)、阿拉伯树胶(G)及其组合物（MG）包封生物钙(B)粉体，采用喷雾干燥的方法提高生物钙(B)粉体的理化性能。在180°C（进口）和60°C（出口）温度下，B与壁材的比例为1:4 （w/w）。粗粉产量在25.2% (15% BG) ~ 30.3% （15% BM）之间，各处理间无显著差异（p > 0.05）。包封粉末的轻度（L*）比b高，5% BG的钙含量和包封效率最高，BM最低。水分含量和水活度分别保持在10%和0.6%以下。BG吸湿性最高，壁浓度无显著影响（p > 0.05）。包封提高了水溶性指数（75.4 - 86.5%），尤其是在BM中。粒径范围从0.92µm （10% BMG）到2.89µm (15% BMG)，而zeta电位范围从-8.71 mV （15% BMG）到-20.90 mV （15% BMG）。包封后的粉末比B更圆润、光滑，BG颗粒呈聚集状，BMG颗粒呈混合状。这些发现表明，包封增强了生物钙的物理化学性质，支持其在钙强化食品和膳食补充剂中的潜在应用。

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引用次数: 0