Pub Date : 2025-06-13DOI: 10.1016/j.fhfh.2025.100226
Ruth Picó-Munyoz, Amparo Tarrega, Laura Laguna
Thickened drinks can be prescribed to ensure the safety of individuals with swallowing difficulties. However, these beverages, especially those with starch-based thickeners, are often less appealing because of their texture and taste. Previous research has indicated that carbonation in water can improve beverage likeability and stimulate muscular activity, potentially helping in safer swallowing. This study investigates the potential of adding carbonation to thickened drinks to enhance oral hydration and alleviate dry mouth and thirst sensations. Nine different water samples prepared with or without a thickener (xanthan gum-based or starch-based) and with still or carbonated water (powder- sparkling water and sparkling commercial water) were studied. Oral moisture, dry mouth, and thirst-quenching sensations were measured before, immediately after, and 5 min after consumption. The two types of carbonation created resulted in different distribution of bubbles. Oral moisture was reduced after consuming thickened water. In addition, the thickened water, with or without carbonation, did not alleviate thirst or dry mouth. Despite the potential safety benefits of carbonation, it did not improve thirst or dry mouth sensations. Future research should explore other stimuli to enhance thirst-quenching capacity, like flavour addition to carbonation to enhance adherence to thickened beverages and body stimulation.
{"title":"The thirst-quenching capacity of carbonated thickened drinks","authors":"Ruth Picó-Munyoz, Amparo Tarrega, Laura Laguna","doi":"10.1016/j.fhfh.2025.100226","DOIUrl":"10.1016/j.fhfh.2025.100226","url":null,"abstract":"<div><div>Thickened drinks can be prescribed to ensure the safety of individuals with swallowing difficulties. However, these beverages, especially those with starch-based thickeners, are often less appealing because of their texture and taste. Previous research has indicated that carbonation in water can improve beverage likeability and stimulate muscular activity, potentially helping in safer swallowing. This study investigates the potential of adding carbonation to thickened drinks to enhance oral hydration and alleviate dry mouth and thirst sensations. Nine different water samples prepared with or without a thickener (xanthan gum-based or starch-based) and with still or carbonated water (powder- sparkling water and sparkling commercial water) were studied. Oral moisture, dry mouth, and thirst-quenching sensations were measured before, immediately after, and 5 min after consumption. The two types of carbonation created resulted in different distribution of bubbles. Oral moisture was reduced after consuming thickened water. In addition, the thickened water, with or without carbonation, did not alleviate thirst or dry mouth. Despite the potential safety benefits of carbonation, it did not improve thirst or dry mouth sensations. Future research should explore other stimuli to enhance thirst-quenching capacity, like flavour addition to carbonation to enhance adherence to thickened beverages and body stimulation.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"8 ","pages":"Article 100226"},"PeriodicalIF":4.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Obesity is a chronic condition and a global epidemic, associated with impaired intestinal permeability owing to dysbiosis. Gut microbiota reportedly plays a potential role in obesity treatment. Probiotics have emerged as the most widely used approach for treating dysbiosis. This study explored the effect of oral probiotic supplementation on intestinal permeability in individuals with obesity.
Methods
A Systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses. PubMed, ScienceDirect, PLOS One, and Cochrane databases were searched to identify articles published between 2014 and September 2024. The Cochrane risk-of-bias tool for randomized trials was used to assess publication bias.
Results
A total of 690 human RCTs (randomized controlled trials) were identified, of which nine were eligible for this review. Probiotics (Akkermansia, Bifidobacterium, Enterococcus, Lactobacillus, Streptococcus, and a combination of Saccharomyces yeast) used for over 8 weeks may decrease gut permeability outcomes, including plasma zonulin, fecal zonulin, plasma or serum LPS, urinary lactulose, and urinary mannitol; however, BMI (body mass index) levels exhibited inconsistent measurements across all groups.
Conclusions
Probiotic supplementation for a minimum of 8 weeks may reduce gut permeability. However, further studies are required to develop standardized protocols for probiotic strains, dosages, durations, and delivery methods, to better understand their effects on intestinal permeability and related outcomes in individuals with obesity.
{"title":"Role of oral probiotic supplementation on gut permeability in obesity: A systematic review of randomized controlled trials","authors":"Alpha Fardah Athiyyah , Triska Susila Nindya , Reza Gunadi Ranuh , Andy Darma , Khadijah Rizky Sumitro , Purwo Sri Rejeki , Lilik Djuari , Subijanto Marto Sudarmo , Rina Agustina","doi":"10.1016/j.fhfh.2025.100225","DOIUrl":"10.1016/j.fhfh.2025.100225","url":null,"abstract":"<div><h3>Background</h3><div>Obesity is a chronic condition and a global epidemic, associated with impaired intestinal permeability owing to dysbiosis. Gut microbiota reportedly plays a potential role in obesity treatment. Probiotics have emerged as the most widely used approach for treating dysbiosis. This study explored the effect of oral probiotic supplementation on intestinal permeability in individuals with obesity.</div></div><div><h3>Methods</h3><div>A Systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses. PubMed, ScienceDirect, PLOS One, and Cochrane databases were searched to identify articles published between 2014 and September 2024. The Cochrane risk-of-bias tool for randomized trials was used to assess publication bias.</div></div><div><h3>Results</h3><div>A total of 690 human RCTs (randomized controlled trials) were identified, of which nine were eligible for this review. Probiotics (<em>Akkermansia, Bifidobacterium, Enterococcus, Lactobacillus, Streptococcus,</em> and a combination of <em>Saccharomyces</em> yeast) used for over 8 weeks may decrease gut permeability outcomes, including plasma zonulin, fecal zonulin, plasma or serum LPS, urinary lactulose, and urinary mannitol; however, BMI (body mass index) levels exhibited inconsistent measurements across all groups.</div></div><div><h3>Conclusions</h3><div>Probiotic supplementation for a minimum of 8 weeks may reduce gut permeability. However, further studies are required to develop standardized protocols for probiotic strains, dosages, durations, and delivery methods, to better understand their effects on intestinal permeability and related outcomes in individuals with obesity.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"8 ","pages":"Article 100225"},"PeriodicalIF":4.6,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144291447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Despite extensive research on protein-based nanoparticles for nutrient delivery, the structural features that govern bile salt interactions and subsequently enhance intestinal absorption and metabolic transformation remain insufficiently clarified. In this study, soy protein isolate nanoparticles enzymatically modified by Alcalase, Neutrase, and Flavorzyme (SPIH-A@NP, SPIHN@NP, SPIH-F@NP) were constructed as structural models to explore the relationship between nanoparticle interfacial properties, bile salt adsorption, and nutrient transport efficiency, using simulated gastrointestinal digestion and Caco-2/HT29 co-culture models. Compared with undigested nanoparticles and free β-carotene, digested nanoparticles exhibited significantly improved cellular uptake and transport efficiencies. Among them, SPIHN@NP and SPIH-F@NP retained more hydrophobic peptides and acidic subunits from 11S globulin, which enhanced bile salt adsorption, maintained smaller particle sizes post-digestion, and facilitated more efficient delivery of β-carotene and its metabolites. Additionally, the digestion process altered uptake pathways, with macropinocytosis contributing more prominently post-digestion. These findings provide mechanistic insight into structure–function relationships that can guide the rational design of protein-based nanocarriers for targeted absorption and metabolic modulation of lipophilic nutrients.
{"title":"Impact of partial enzymatic hydrolysis on the transport and uptake of SPI nanoparticles post-digestion","authors":"Ling Chen , Yuan Lv , Xiaoyong Wang , Maoshen Chen , Hui Zhang","doi":"10.1016/j.fhfh.2025.100223","DOIUrl":"10.1016/j.fhfh.2025.100223","url":null,"abstract":"<div><div>Despite extensive research on protein-based nanoparticles for nutrient delivery, the structural features that govern bile salt interactions and subsequently enhance intestinal absorption and metabolic transformation remain insufficiently clarified. In this study, soy protein isolate nanoparticles enzymatically modified by Alcalase, Neutrase, and Flavorzyme (SPIH-A@NP, SPIH<img>N@NP, SPIH-F@NP) were constructed as structural models to explore the relationship between nanoparticle interfacial properties, bile salt adsorption, and nutrient transport efficiency, using simulated gastrointestinal digestion and Caco-2/HT29 co-culture models. Compared with undigested nanoparticles and free <em>β</em>-carotene, digested nanoparticles exhibited significantly improved cellular uptake and transport efficiencies. Among them, SPIH<img>N@NP and SPIH-F@NP retained more hydrophobic peptides and acidic subunits from 11S globulin, which enhanced bile salt adsorption, maintained smaller particle sizes post-digestion, and facilitated more efficient delivery of <em>β</em>-carotene and its metabolites. Additionally, the digestion process altered uptake pathways, with macropinocytosis contributing more prominently post-digestion. These findings provide mechanistic insight into structure–function relationships that can guide the rational design of protein-based nanocarriers for targeted absorption and metabolic modulation of lipophilic nutrients.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"7 ","pages":"Article 100223"},"PeriodicalIF":4.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01DOI: 10.1016/j.fhfh.2025.100224
Lei Zhang , Minglu Hao , Liang Yao , Linyuan Xue , Jingmou Yu , Dongming Xing , Pu Chen
In this study, we investigated the potential of a food derivative sericin nanogel-anthocyanin (SNG-C3G) nanocomposite to enhance the anticancer effects of various chemotherapeutic drugs, including irinotecan (IRI), paclitaxel (PTX), and oxaliplatin (OXA), on different cell lines such as HeLa, HSEC, and HEK293T. The SNG-C3G nanocomposites exhibited a uniform spherical morphology, and upon co-encapsulation with either IRI or PTX, the particle size and zeta potential remained relatively consistent, ranging from 24.96 to 29.44 nm and −18.37 to −23.67 mV, respectively. Our findings indicate a marked increase in the anticancer effectiveness when these drugs are combined with the SNG-C3G nanocomposite. Focusing on the interaction with PTX, our proteomic analysis revealed significant changes in cell behavior, including cytoprotective mechanisms, ligand interactions, stress response, and pathways associated with oxidative and metabolic detoxification. Specifically, 13 proteins were upregulated and 10 were downregulated in the SNG-C3G-PTX group compared to the PTX-only group. The strong antioxidant properties of C3G might stand out as a key factor in enhancing these effects. This study suggests the potential for developing new cancer treatment strategies that utilize anthocyanins to boost the effectiveness of traditional chemotherapy protocols.
{"title":"Synergistic anticancer enhancement: Sericin nanogels co-delivery of anthocyanin and cancer drugs irinotecan, paclitaxel, and oxaliplatin","authors":"Lei Zhang , Minglu Hao , Liang Yao , Linyuan Xue , Jingmou Yu , Dongming Xing , Pu Chen","doi":"10.1016/j.fhfh.2025.100224","DOIUrl":"10.1016/j.fhfh.2025.100224","url":null,"abstract":"<div><div>In this study, we investigated the potential of a food derivative sericin nanogel-anthocyanin (SNG-C3G) nanocomposite to enhance the anticancer effects of various chemotherapeutic drugs, including irinotecan (IRI), paclitaxel (PTX), and oxaliplatin (OXA), on different cell lines such as HeLa, HSEC, and HEK293T. The SNG-C3G nanocomposites exhibited a uniform spherical morphology, and upon co-encapsulation with either IRI or PTX, the particle size and zeta potential remained relatively consistent, ranging from 24.96 to 29.44 nm and −18.37 to −23.67 mV, respectively. Our findings indicate a marked increase in the anticancer effectiveness when these drugs are combined with the SNG-C3G nanocomposite. Focusing on the interaction with PTX, our proteomic analysis revealed significant changes in cell behavior, including cytoprotective mechanisms, ligand interactions, stress response, and pathways associated with oxidative and metabolic detoxification. Specifically, 13 proteins were upregulated and 10 were downregulated in the SNG-C3G-PTX group compared to the PTX-only group. The strong antioxidant properties of C3G might stand out as a key factor in enhancing these effects. This study suggests the potential for developing new cancer treatment strategies that utilize anthocyanins to boost the effectiveness of traditional chemotherapy protocols.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"7 ","pages":"Article 100224"},"PeriodicalIF":4.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144253535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-20DOI: 10.1016/j.fhfh.2025.100222
F. Morovat , M. Karimi , R. Dehdari Vais , M. Negahdary , S.A. Dastgheib , H. Heli
Nanocarriers based on (natural) lipids have been extensively studied to improve the oral bioavailability of anticancer compounds/drugs with poor water solubility. Self-nanoemulsifying drug delivery systems (SNEDDSs) are a route to improve the solubility and bioavailability of lipophilic compounds. In a present study, an SNEDDS using the oil extract of Mentha spicata L. leaves, Tween 80, and PEG 600 (SMO) was prepared. Pseudo-ternary phase diagrams were constructed to find suitable surfactant, solubilizer with the oil extract that form self-nanoemulsion after dilution in water. SMO comprised Tween 80:PEG 600:the oil with 2:3:5 in volume ratios or 2.1:3.4:4.5 in mass ratios. It comprised nanodroplets of 82.5 ± 4.7 nm in diameter and had a stability of >45 days. SMO led to enhanced cytotoxicity of the oil extract with IC-50 values of 1.9 ± 0.1 and 2.0 ± 0.1 mg mL−1 for MDA-MB-231 and MCF-7 cells, respectively. SMO would be applicable for delivery of either water insoluble chemotherapeutic drugs or natural anticancer oils upon more investigations.
{"title":"Development of a self-nanoemulsifying system for the oil extract of Mentha spicata L. and evaluation of its anticancer efficacy in vitro","authors":"F. Morovat , M. Karimi , R. Dehdari Vais , M. Negahdary , S.A. Dastgheib , H. Heli","doi":"10.1016/j.fhfh.2025.100222","DOIUrl":"10.1016/j.fhfh.2025.100222","url":null,"abstract":"<div><div>Nanocarriers based on (natural) lipids have been extensively studied to improve the oral bioavailability of anticancer compounds/drugs with poor water solubility. Self-nanoemulsifying drug delivery systems (SNEDDSs) are a route to improve the solubility and bioavailability of lipophilic compounds. In a present study, an SNEDDS using the oil extract of <em>Mentha spicata</em> L. leaves, Tween 80, and PEG 600 (SMO) was prepared. Pseudo-ternary phase diagrams were constructed to find suitable surfactant, solubilizer with the oil extract that form self-nanoemulsion after dilution in water. SMO comprised Tween 80:PEG 600:the oil with 2:3:5 in volume ratios or 2.1:3.4:4.5 in mass ratios. It comprised nanodroplets of 82.5 ± 4.7 nm in diameter and had a stability of >45 days. SMO led to enhanced cytotoxicity of the oil extract with IC-50 values of 1.9 ± 0.1 and 2.0 ± 0.1 mg mL<sup>−1</sup> for MDA-MB-231 and MCF-7 cells, respectively. SMO would be applicable for delivery of either water insoluble chemotherapeutic drugs or natural anticancer oils upon more investigations.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"7 ","pages":"Article 100222"},"PeriodicalIF":4.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-20DOI: 10.1016/j.fhfh.2025.100221
Rhowell Navarro Tiozon Jr. , Glenn Vincent P. Ong , Kristel June D. Sartagoda , Sheba Mae M. Duque , Saleh Alseekh , Aldrin P. Bonto , Shem Gempesaw Jr. , Vipin Pratap , Florencio C. Reginio Jr. , Jonina Marie J. Tengco , Christian Seagan , Joel H G Tolentino , Dennis Marvin O. Santiago , Alisdair R. Fernie , Nese Sreenivasulu
Pigmented paddy rice is rich in a diverse array of phytochemicals that confer notable antioxidant and anticancer properties. However, the stability and bioaccessibility of these bioactive compounds present significant challenges. In this study, 542 brown (including pigmented and non-pigmented) whole grain rice samples were screened for their antioxidant components and capacity, leading to the identification of three superior cultivars: Balatinao variable purple rice, Ketan Hitam variable purple rice, and Kintuman red rice. Using response surface methodology, rice bran extracts from these cultivars were subjected to microencapsulation to stabilize the phytochemicals. Among the microencapsulated rice bran extracts (MRBEs), Ketan Hitam MRBE demonstrated significantly higher total phenolic content (TPC) and antioxidant capacity. This enhancement is likely due to the increased concentrations of isovitexin, luteolin 7-glucoside, and vitexin following microencapsulation. Furthermore, compared to non-encapsulated rice bran extracts, MRBEs exhibited significantly improved anticancer activity against HCT116 (colon) and A549 (lung) cancer cell lines (P < 0.05). Subsequent fractionation of the MRBE allowed for the identification of the most bioactive fractions, which contained metabolites effective against these cancer cell lines. In addition, in vitro bioaccessibility assays revealed a controlled release of 19 targeted phenolic compounds. This release profile was characterized by an initial increase during the gastric digestion phase, followed by a decrease in the intestinal phase. Notably, phenolic compounds such as chlorogenic acid, gallic acid, and vanillin were preserved across the three rice varieties after microencapsulation. These findings underscore the potential of MRBEs as functional food ingredients or supplements, offering improved bioaccessibility of phenolics, enhanced antioxidant properties, and promising anticancer activity. The results support the integration of rice bran extracts into the rice value chain, promoting their use in functional health applications.
{"title":"Optimization of phenolic extraction method and in vitro bioaccessibility of microencapsulated pigmented rice bran extracts and their antioxidant and anticancer properties","authors":"Rhowell Navarro Tiozon Jr. , Glenn Vincent P. Ong , Kristel June D. Sartagoda , Sheba Mae M. Duque , Saleh Alseekh , Aldrin P. Bonto , Shem Gempesaw Jr. , Vipin Pratap , Florencio C. Reginio Jr. , Jonina Marie J. Tengco , Christian Seagan , Joel H G Tolentino , Dennis Marvin O. Santiago , Alisdair R. Fernie , Nese Sreenivasulu","doi":"10.1016/j.fhfh.2025.100221","DOIUrl":"10.1016/j.fhfh.2025.100221","url":null,"abstract":"<div><div>Pigmented paddy rice is rich in a diverse array of phytochemicals that confer notable antioxidant and anticancer properties. However, the stability and bioaccessibility of these bioactive compounds present significant challenges. In this study, 542 brown (including pigmented and non-pigmented) whole grain rice samples were screened for their antioxidant components and capacity, leading to the identification of three superior cultivars: Balatinao variable purple rice, Ketan Hitam variable purple rice, and Kintuman red rice. Using response surface methodology, rice bran extracts from these cultivars were subjected to microencapsulation to stabilize the phytochemicals. Among the microencapsulated rice bran extracts (MRBEs), Ketan Hitam MRBE demonstrated significantly higher total phenolic content (TPC) and antioxidant capacity. This enhancement is likely due to the increased concentrations of isovitexin, luteolin 7-glucoside, and vitexin following microencapsulation. Furthermore, compared to non-encapsulated rice bran extracts, MRBEs exhibited significantly improved anticancer activity against HCT116 (colon) and A549 (lung) cancer cell lines (<em>P</em> < 0.05). Subsequent fractionation of the MRBE allowed for the identification of the most bioactive fractions, which contained metabolites effective against these cancer cell lines. In addition, <em>in vitro</em> bioaccessibility assays revealed a controlled release of 19 targeted phenolic compounds. This release profile was characterized by an initial increase during the gastric digestion phase, followed by a decrease in the intestinal phase. Notably, phenolic compounds such as chlorogenic acid, gallic acid, and vanillin were preserved across the three rice varieties after microencapsulation. These findings underscore the potential of MRBEs as functional food ingredients or supplements, offering improved bioaccessibility of phenolics, enhanced antioxidant properties, and promising anticancer activity. The results support the integration of rice bran extracts into the rice value chain, promoting their use in functional health applications.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"7 ","pages":"Article 100221"},"PeriodicalIF":4.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144130942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-16DOI: 10.1016/j.fhfh.2025.100219
Juan Carlos SOLOMANDO, Teresa ANTEQUERA, Abraham Pajuelo, Jorge RUIZ-CARRASCAL, Trinidad PEREZ-PALACIOS
This study aimed to develop salt microcapsules using different wall materials to achieve stable encapsulated salt systems with optimal water solubilization and controlled salt release in the oral cavity, leading to an acceptable saltiness perception in food matrices. Six types of salt microcapsules were prepared, uncoated salt (CONT) and coated with maltodextrin (MALT), chitosan (QUIT), double emulsion (DOBL), alginate (ALGI), and liposomes (LIPO).
Significant differences were observed in size distribution, intermolecular forces, solubility index, salt release during oral digestion, and sensory evaluation. MALT microcapsules exhibited the most homogeneous size distribution, while ALGI showed the smallest particle size (D(4.3) = 0.27 μm). QUIT and DOBL microcapsules demonstrated the strongest intermolecular interactions between Na+ and Cl− ions and their respective wall materials, giving the lowest solubility (77.95 and 58.74 %) and oral salt release values (39.51 and 45.87 %). Contrarily, CONT, MALT, ALGI, and LIPO microcapsules exhibited higher solubility (99.77, 90.33, 92.65 and 86.01 %) and salt release (96.62, 83.08, 88.22 and 86.01 %).
Sensory analysis revealed that coated salt microcapsules enhanced the perception of saltiness compared to uncoated samples, demonstrating the potential of salt encapsulation as a strategy to reduce overall sodium content in foods without compromising taste. However, QUIT and ALGI microcapsules received the lowest hedonic scores, possibly due to undesirable sensory attributes associated with their wall materials.
Overall, MALT, DOBL, and LIPO microcapsules emerged as the most promising formulations, offering a balance of favorable characteristics across multiple parameters and highlighting their potential application in the development of reduced-sodium food products.
{"title":"Development of sodium chloride microcapsules as saltiness enhancement strategy","authors":"Juan Carlos SOLOMANDO, Teresa ANTEQUERA, Abraham Pajuelo, Jorge RUIZ-CARRASCAL, Trinidad PEREZ-PALACIOS","doi":"10.1016/j.fhfh.2025.100219","DOIUrl":"10.1016/j.fhfh.2025.100219","url":null,"abstract":"<div><div>This study aimed to develop salt microcapsules using different wall materials to achieve stable encapsulated salt systems with optimal water solubilization and controlled salt release in the oral cavity, leading to an acceptable saltiness perception in food matrices. Six types of salt microcapsules were prepared, uncoated salt (CONT) and coated with maltodextrin (MALT), chitosan (QUIT), double emulsion (DOBL), alginate (ALGI), and liposomes (LIPO).</div><div>Significant differences were observed in size distribution, intermolecular forces, solubility index, salt release during oral digestion, and sensory evaluation. MALT microcapsules exhibited the most homogeneous size distribution, while ALGI showed the smallest particle size (D(4.3) = 0.27 μm). QUIT and DOBL microcapsules demonstrated the strongest intermolecular interactions between Na+ and Cl− ions and their respective wall materials, giving the lowest solubility (77.95 and 58.74 %) and oral salt release values (39.51 and 45.87 %). Contrarily, CONT, MALT, ALGI, and LIPO microcapsules exhibited higher solubility (99.77, 90.33, 92.65 and 86.01 %) and salt release (96.62, 83.08, 88.22 and 86.01 %).</div><div>Sensory analysis revealed that coated salt microcapsules enhanced the perception of saltiness compared to uncoated samples, demonstrating the potential of salt encapsulation as a strategy to reduce overall sodium content in foods without compromising taste. However, QUIT and ALGI microcapsules received the lowest hedonic scores, possibly due to undesirable sensory attributes associated with their wall materials.</div><div>Overall, MALT, DOBL, and LIPO microcapsules emerged as the most promising formulations, offering a balance of favorable characteristics across multiple parameters and highlighting their potential application in the development of reduced-sodium food products.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"7 ","pages":"Article 100219"},"PeriodicalIF":4.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aimed to develop an optimal formulation for an orodispersible film containing essential oil from Zanthoxylum rhetsa (ZR film) using response surface methodology with a Box-Behnken design experiment and to evaluate its antioxidant and antiglycation activities. Three independent variables—gelatin (1–3 % w/v), carrageenan (0.5–1.5 % w/v), and essential oil from Z. rhetsa fruits (1–3 % w/v)—were utilized to design a ZR film with desirable characteristics. Dependent variables, including film thickness, moisture content, and disintegration time, were assessed. The optimized formulation contained 1 % w/v gelatin, 0.5 % w/v carrageenan, and 2.6 % w/v essential oil from Z. rhetsa fruits. The optimized ZR film exhibited a thickness of 14.2 ± 2.12 µm, a disintegration time of 6.34 ± 0.53 min, and a moisture content of 3.32 ± 0.56 %. Total phenolic content was 55.3 ± 0.4 mg GAE/g, and ABTS radical scavenging capacity was 0.06 ± 0.02 g TEAC/g. Additionally, the ZR film inhibited the formation of advanced glycation end products (AGEs) by 66.97 ± 0.58 %. This ZR film shows promise as a potential oral healthcare product for managing oxidative stress and glycation-related pathologies.
{"title":"Formulation optimization of orodispersible film containing essential oil from fruits of Zanthoxylum rhetsa (Roxb.) DC. using response surface methodology and evaluation of its antioxidant, and antiglycation activities","authors":"Pimpikar Kanchanadumkerng , Vilasinee Hirunpanich Sato , Nattawut Charoenthai , Thongtham Suksawat , Pattamapan Lomarat , Savita Chewchinda","doi":"10.1016/j.fhfh.2025.100220","DOIUrl":"10.1016/j.fhfh.2025.100220","url":null,"abstract":"<div><div>This study aimed to develop an optimal formulation for an orodispersible film containing essential oil from <em>Zanthoxylum rhetsa</em> (ZR film) using response surface methodology with a Box-Behnken design experiment and to evaluate its antioxidant and antiglycation activities. Three independent variables—gelatin (1–3 % w/v), carrageenan (0.5–1.5 % w/v), and essential oil from <em>Z. rhetsa</em> fruits (1–3 % w/v)—were utilized to design a ZR film with desirable characteristics. Dependent variables, including film thickness, moisture content, and disintegration time, were assessed. The optimized formulation contained 1 % w/v gelatin, 0.5 % w/v carrageenan, and 2.6 % w/v essential oil from <em>Z. rhetsa</em> fruits. The optimized ZR film exhibited a thickness of 14.2 ± 2.12 µm, a disintegration time of 6.34 ± 0.53 min, and a moisture content of 3.32 ± 0.56 %. Total phenolic content was 55.3 ± 0.4 mg GAE/g, and ABTS radical scavenging capacity was 0.06 ± 0.02 g TEAC/g. Additionally, the ZR film inhibited the formation of advanced glycation end products (AGEs) by 66.97 ± 0.58 %. This ZR film shows promise as a potential oral healthcare product for managing oxidative stress and glycation-related pathologies.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"7 ","pages":"Article 100220"},"PeriodicalIF":4.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-13DOI: 10.1016/j.fhfh.2025.100218
Felipe Galvez-Jiron , Lucas de Freitas Pedrosa , Luis Silva Lagos , Xin Tang , Traudy Wandersleben , Rodrigo Navia , Stephan Drusch , Francisca Acevedo , Paul de Vos
Wound healing and gut epithelial barrier regulation are crucial for intestinal homeostasis. Effective repair of gut epithelial wounds is crucial for re-establishing the mucosal barrier and resolving inflammation. Pectins, versatile polysaccharides in food, protect sensitive components, such as living bacteria, during gastrointestinal transit and support wound healing by promoting cell proliferation and migration.
This study investigated the effects of encapsulated Lactobacillus plantarum WCFS1 on cell proliferation and migration during epithelial wound healing, using pectin-based beads stabilized with alginate or chitosan. Pectin from lemon, with two degrees of methyl esterification (DM18 and DM88), produced four microbead types. T84 cells were incubated with these beads for 24 hours. The results revealed that cell proliferation and migration were influenced by the bead type, the degree of methyl esterification of the pectin, and the inclusion of L. plantarum. Empty DM88 pectin beads improved cell proliferation while reducing migration tendencies, whereas DM18 beads delayed migration.Beads containing L. plantarum demonstrated different effects: DM18 beads enhanced proliferation without inhibiting migration, while DM88 beads reduced migration. Both empty and L. plantarum-loaded beads decreased CCL20 production. Alginate/pectin beads with L. plantarum increased IL-8, while chitosan/pectin beads delayed migration, reduced CCL20 secretion, and modulated IL-8 levels.
In conclusion, DM88 pectin beads without L. plantarum and DM18 beads containing L. plantarum supported cell proliferation over migration during epithelial wound healing. These findings suggest that pectin-based encapsulation systems may play a role in promoting gut health, protecting barrier integrity, and delivering therapeutic agents.
{"title":"Lactobacillus plantarum in high methoxylated pectin-based encapsulation systems supports gut epithelial wound healing in vitro","authors":"Felipe Galvez-Jiron , Lucas de Freitas Pedrosa , Luis Silva Lagos , Xin Tang , Traudy Wandersleben , Rodrigo Navia , Stephan Drusch , Francisca Acevedo , Paul de Vos","doi":"10.1016/j.fhfh.2025.100218","DOIUrl":"10.1016/j.fhfh.2025.100218","url":null,"abstract":"<div><div>Wound healing and gut epithelial barrier regulation are crucial for intestinal homeostasis. Effective repair of gut epithelial wounds is crucial for re-establishing the mucosal barrier and resolving inflammation. Pectins, versatile polysaccharides in food, protect sensitive components, such as living bacteria, during gastrointestinal transit and support wound healing by promoting cell proliferation and migration.</div><div>This study investigated the effects of encapsulated <em>Lactobacillus plantarum WCFS1</em> on cell proliferation and migration during epithelial wound healing, using pectin-based beads stabilized with alginate or chitosan. Pectin from lemon, with two degrees of methyl esterification (DM18 and DM88), produced four microbead types. T84 cells were incubated with these beads for 24 hours. The results revealed that cell proliferation and migration were influenced by the bead type, the degree of methyl esterification of the pectin, and the inclusion of <em>L. plantarum</em>. Empty DM88 pectin beads improved cell proliferation while reducing migration tendencies, whereas DM18 beads delayed migration.Beads containing <em>L. plantarum</em> demonstrated different effects: DM18 beads enhanced proliferation without inhibiting migration, while DM88 beads reduced migration. Both empty and <em>L. plantarum</em>-loaded beads decreased CCL20 production. Alginate/pectin beads with <em>L. plantarum</em> increased IL-8, while chitosan/pectin beads delayed migration, reduced CCL20 secretion, and modulated IL-8 levels.</div><div>In conclusion, DM88 pectin beads without <em>L. plantarum</em> and DM18 beads containing <em>L. plantarum</em> supported cell proliferation over migration during epithelial wound healing. These findings suggest that pectin-based encapsulation systems may play a role in promoting gut health, protecting barrier integrity, and delivering therapeutic agents.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"7 ","pages":"Article 100218"},"PeriodicalIF":4.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bamboo shoot soluble dietary fiber (DBS-SDF) has numerous health-promoting benefits, but its protective effects and potential mechanism against obesity-related metabolic disorders remain unclear. The effects of DBS-SDF on metabolic disorders induced by a high-fat diet (HFD) in mice was studied. Supplementation with DBS-SDF alleviated the development of HFD-induced obesity and related symptoms by lowering serum lipid levels, preventing lipid degeneration, and modulating the expression levels of genes related to lipid synthesis and decomposition in the liver. At the same time, DBS-SDF reversed the enlargement of white adipose cells, prevented the whitening of brown adipose tissue, and activated fat browning to improve energy balance. In addition, DBS-SDF reshaped the structure of the gut microbiota, significantly reducing the ratio of Firmicutes/Bacteroidetes, promoting the proliferation of SCFA producing bacteria Ligilactobacillus, unclassified_Muribaculaceae, and Lachnospiraceae_NK4A136_group, while inhibiting harmful bacterial populations such as Faecalibaculum and Desulfovibrio. These effects are related to the enhancement of the intestinal barrier, such as upregulation of Intectin expression, increased secretion of mucin MUC2, and increased expression of tight junction proteins. Spearman correlation analysis revealed significant associations between obesity related indicators, intestinal barrier, and gut microbiota, emphasizing the improvement effect of DBS-SDF on metabolic disorders through a healthy gut microenvironment. These findings indicate that DBS-SDF has enormous potential in the development of prebiotics or functional foods.
{"title":"Beneficial effects of soluble dietary fiber from Dendrocalamus brandisii Munro shoots on high-fat diet-induced metabolic disorders in mice: Impact on liver, adipose tissue, and intestinal health","authors":"Mingtian Tian , Jiahong Dong , Yuhong Guo , Yihe Zhao , Jianxin Cao","doi":"10.1016/j.fhfh.2025.100217","DOIUrl":"10.1016/j.fhfh.2025.100217","url":null,"abstract":"<div><div>Bamboo shoot soluble dietary fiber (DBS-SDF) has numerous health-promoting benefits, but its protective effects and potential mechanism against obesity-related metabolic disorders remain unclear. The effects of DBS-SDF on metabolic disorders induced by a high-fat diet (HFD) in mice was studied. Supplementation with DBS-SDF alleviated the development of HFD-induced obesity and related symptoms by lowering serum lipid levels, preventing lipid degeneration, and modulating the expression levels of genes related to lipid synthesis and decomposition in the liver. At the same time, DBS-SDF reversed the enlargement of white adipose cells, prevented the whitening of brown adipose tissue, and activated fat browning to improve energy balance. In addition, DBS-SDF reshaped the structure of the gut microbiota, significantly reducing the ratio of Firmicutes/Bacteroidetes, promoting the proliferation of SCFA producing bacteria <em>Ligilactobacillus</em>, unclassified_<em>Muribaculaceae</em>, and <em>Lachnospiraceae</em>_NK4A136_group, while inhibiting harmful bacterial populations such as <em>Faecalibaculum</em> and <em>Desulfovibrio</em>. These effects are related to the enhancement of the intestinal barrier, such as upregulation of Intectin expression, increased secretion of mucin MUC2, and increased expression of tight junction proteins. Spearman correlation analysis revealed significant associations between obesity related indicators, intestinal barrier, and gut microbiota, emphasizing the improvement effect of DBS-SDF on metabolic disorders through a healthy gut microenvironment. These findings indicate that DBS-SDF has enormous potential in the development of prebiotics or functional foods.</div></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":"7 ","pages":"Article 100217"},"PeriodicalIF":4.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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