Pub Date : 2021-01-01DOI: 10.36648/1791-809X.15.3.819
Edvaldo Virgínio da Silva Junior, Inaldo Freire Cavalcanti, Caio Ferreira Santos, T. M. P. Prazeres, W. S. Gomes, Matheus Santos de Sousa Fern, es, José Raphael Leandro da Costa Silva, Jéssica Gomes Gonçalves, M. Santos, R. Henrique
Aim: The aim of this study was to examine the differences in anthropometric characteristics and body composition of elite soccer athletes, according to playing position and function performed. Methods: Ninety-seven elite athletes (24.68 ± 4.21 years) from a first division team of Brazilian soccer were assessed for body mass, stature and seven skinfolds, to determine body mass index, fat percentage, as well as fat mass and fat-free mass. Differences in the anthropometric characteristics and body composition, according to playing positions and function performed were evaluated with the Multivariate Analysis of Variance (MANOVA).Quantitative chances of finding differences and effect sizes (ES) were also interpreted. Results: Goalkeepers (GO) and central defenders (CD) had likely to most likely higher stature and body mass than fullbacks (FB), defensive (DM) and offensive (OM) midfielders, and forwards (FW) (ES varying between 0.92 and 2.62); DM had also higher body mass than OM (ES=1.04). GO likely to very likely had higher body fat percentage and fat-free mass than other positions (ES varying between 1.49 and 2.07). OM likely to very likely had lower fat mass than GO, CD and DM (ES varying between 1.04 to 2.06). FB likely to very likely had also lower fat mass than GO and CD (ES=1.29 and 1.73, respectively). Conclusion: Our results provide useful information for help coaches and other soccer professionals in the planning and control of training and nutrition in elite Brazilian soccer athletes.
目的:本研究的目的是研究优秀足球运动员的人体测量特征和身体组成的差异,根据比赛位置和功能进行。方法:对97名巴西足球甲级球队优秀运动员(24.68±4.21岁)进行体重、身高、7个皮肤褶的测定,测定体重指数、脂肪率、脂肪质量和无脂肪质量。采用多元方差分析(Multivariate Analysis of Variance, MANOVA)评估不同运动位置和运动功能的人体测量特征和身体组成差异。还解释了发现差异的定量机会和效应大小(ES)。结果:守门员(GO)和中卫(CD)最有可能比边后卫(FB)、防守中场(DM)和进攻中场(OM)和前锋(FW)具有更高的身高和体重(ES在0.92 ~ 2.62之间);DM的体重也高于OM (ES=1.04)。与其他体位相比,GO体位的体脂率和无脂质量很可能更高(ES在1.49和2.07之间变化)。与氧化石墨烯、乳糜酐和糖尿病相比,氧化石墨烯极有可能具有更低的脂肪量(ES在1.04至2.06之间变化)。与氧化石墨烯和乳糜泻相比,氧化石墨烯极有可能具有更低的脂肪量(ES分别为1.29和1.73)。结论:本研究结果为巴西优秀足球运动员的训练和营养的规划和控制提供了有益的信息。
{"title":"Anthropometry and Body Composition of Elite Brazilian Soccer Players according to the Playing Position","authors":"Edvaldo Virgínio da Silva Junior, Inaldo Freire Cavalcanti, Caio Ferreira Santos, T. M. P. Prazeres, W. S. Gomes, Matheus Santos de Sousa Fern, es, José Raphael Leandro da Costa Silva, Jéssica Gomes Gonçalves, M. Santos, R. Henrique","doi":"10.36648/1791-809X.15.3.819","DOIUrl":"https://doi.org/10.36648/1791-809X.15.3.819","url":null,"abstract":"Aim: The aim of this study was to examine the differences in anthropometric characteristics and body composition of elite soccer athletes, according to playing position and function performed. Methods: Ninety-seven elite athletes (24.68 ± 4.21 years) from a first division team of Brazilian soccer were assessed for body mass, stature and seven skinfolds, to determine body mass index, fat percentage, as well as fat mass and fat-free mass. Differences in the anthropometric characteristics and body composition, according to playing positions and function performed were evaluated with the Multivariate Analysis of Variance (MANOVA).Quantitative chances of finding differences and effect sizes (ES) were also interpreted. Results: Goalkeepers (GO) and central defenders (CD) had likely to most likely higher stature and body mass than fullbacks (FB), defensive (DM) and offensive (OM) midfielders, and forwards (FW) (ES varying between 0.92 and 2.62); DM had also higher body mass than OM (ES=1.04). GO likely to very likely had higher body fat percentage and fat-free mass than other positions (ES varying between 1.49 and 2.07). OM likely to very likely had lower fat mass than GO, CD and DM (ES varying between 1.04 to 2.06). FB likely to very likely had also lower fat mass than GO and CD (ES=1.29 and 1.73, respectively). Conclusion: Our results provide useful information for help coaches and other soccer professionals in the planning and control of training and nutrition in elite Brazilian soccer athletes.","PeriodicalId":12868,"journal":{"name":"Health science journal","volume":"219 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77696461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/1791-809X.21.15.853
Ayenew Assefa, D. Geremew, Tadelo Wondmagegn
Background: Asthma is a chronic respiratory disorder having both genetic and environmental underlying risk factors. Immunoglobulin E (IgE) is known to play a critical role in asthma pathogenesis and has also main function in immune response to parasites such as helminths. In this research, we aimed to assess total serum IgE level and associated factors among asthmatic patients at the University of Gondar Hospital, Gondar, Northwest Ethiopia. Methods: A comparative cross-sectional study was conducted from June to August 2019 at the University of Gondar Hospital among asthmatic patients. A structured questionnaire was used to collect socio-demographic characteristics of patients. Venous blood was collected from asthmatic patients to determine total IgE and cholesterol levels. A stool examination was also done among the patients. Stored serum sample from blood donors was used as control. Data was analyzed using SPSS version 20. ANOVA, Kruskal Wallis test, spearman’s correlation, chi-square, and binary logistic regressions were used in data analysis. P-value ≤ 0.05 was considered statistically significant. Results: A total of 88 study subjects were included. The geometric mean of total IgE level was 366.6 ± 5.4 IU/ml and 52.2 ± 3.6 IU/ml for patients and controls respectively (p<0.001). The geometric mean total IgE levels of patients with positive and negative helminth infection were 1282.9 ± 3.6 IU/ml and 294.4 ± 5.6 IU/ml respectively (p=0.237). The geometric mean total IgE level for moderate-severe groups of asthmatics was 367.4 ± 5.6 IU/ml and intermittent-mild groups were 321.2 ± 5.4 IU/ml (p=0.803). The association of cholesterol level and total IgE level among patients was found to be negative and non-significant (with an odds ratio of 0.995 and 95% confidence interval (CI) of 0.982-1.009) (p=0.507). Conclusion: This study showed significantly higher total IgE levels in asthmatics than controls. Hence, assessment of total IgE level in asthmatics is a direct measurement of airway inflammation and estimation of total IgE level should be included in routine practice. Non-significant differences and associations were found between total IgE levels and associated factors among patients.
{"title":"Assessment of Total Serum IgE Level and Associated Factors among Asthmatic Patients at University of Gondar Hospital, Gondar, Northwest Ethiopia","authors":"Ayenew Assefa, D. Geremew, Tadelo Wondmagegn","doi":"10.36648/1791-809X.21.15.853","DOIUrl":"https://doi.org/10.36648/1791-809X.21.15.853","url":null,"abstract":"Background: Asthma is a chronic respiratory disorder having both genetic and environmental underlying risk factors. Immunoglobulin E (IgE) is known to play a critical role in asthma pathogenesis and has also main function in immune response to parasites such as helminths. In this research, we aimed to assess total serum IgE level and associated factors among asthmatic patients at the University of Gondar Hospital, Gondar, Northwest Ethiopia. Methods: A comparative cross-sectional study was conducted from June to August 2019 at the University of Gondar Hospital among asthmatic patients. A structured questionnaire was used to collect socio-demographic characteristics of patients. Venous blood was collected from asthmatic patients to determine total IgE and cholesterol levels. A stool examination was also done among the patients. Stored serum sample from blood donors was used as control. Data was analyzed using SPSS version 20. ANOVA, Kruskal Wallis test, spearman’s correlation, chi-square, and binary logistic regressions were used in data analysis. P-value ≤ 0.05 was considered statistically significant. Results: A total of 88 study subjects were included. The geometric mean of total IgE level was 366.6 ± 5.4 IU/ml and 52.2 ± 3.6 IU/ml for patients and controls respectively (p<0.001). The geometric mean total IgE levels of patients with positive and negative helminth infection were 1282.9 ± 3.6 IU/ml and 294.4 ± 5.6 IU/ml respectively (p=0.237). The geometric mean total IgE level for moderate-severe groups of asthmatics was 367.4 ± 5.6 IU/ml and intermittent-mild groups were 321.2 ± 5.4 IU/ml (p=0.803). The association of cholesterol level and total IgE level among patients was found to be negative and non-significant (with an odds ratio of 0.995 and 95% confidence interval (CI) of 0.982-1.009) (p=0.507). Conclusion: This study showed significantly higher total IgE levels in asthmatics than controls. Hence, assessment of total IgE level in asthmatics is a direct measurement of airway inflammation and estimation of total IgE level should be included in routine practice. Non-significant differences and associations were found between total IgE levels and associated factors among patients.","PeriodicalId":12868,"journal":{"name":"Health science journal","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83619058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/1791-809X.21.15.824
Joyce Souza Santana, Thamires Beatriz Belo Serrão, C. Dias, M. Paixão, C. Mendes, Breno Henrique Silva da Silva, Luciane Lobato Sobral Santos, Rodrigo Santiago Barbosa Rocha, Larissa Salgado de Oliveira Rocha
Objective: To verify the influence of paramedical micro pigmentation on areolas on the quality of life of mastectomized women with breast reconstruction. Method: The study was conducted with fifteen volunteers with a mean age of 51.87 ± 12.13 years, submitted to mastectomy in an average time of 12.9± 35 months, followed by breast reconstruction with a mean time of 9.6± 9.91 months and who underwent the treatment of areolar paramedical micro pigmentation with an average time of 18.31 ± 10.45 months. In the micro pigmentation of the areolas was using the needle of one and three tips, with pigments. Later, they were evaluated by analysis of photographic images, by the Breast Cancer Scale - FACT-B. In addition, the volunteers answered a questionnaire that corresponded to the quality of life after breast reconstruction - EORTC QLQ - BRECON23. Descriptive analysis and the ANOVA test followed by Tukey (p<0.05) were used. Results: It was verified in the EORTC-BR23 questionnaire that the volunteers presented scores that indicated the side effects of treatment and symptoms at the place of withdrawal, low level of symptomatology or problems. However, for the scores satisfaction with the nipples and sexual function there was a low degree of satisfaction. Regarding the FACT-B questionnaire, in the additional concerns domain, an average value of 215.16 was observed, while the satisfaction of the volunteers was lower in the social/family well-being domains with significant mean values of 23.64, and functional well-being of 18.13 (p<0.05). Conclusion: It is concluded that micro pigmentation after breast reconstruction becomes acceptable with regard to the self-esteem of volunteers, allowing (re)inclusion in society for improvement of their self-esteem, self-image and thus promoting improvement in quality of life.
{"title":"Paramedic Micropigmentation in Areols as a Factor in The Improvement of the Quality of Life of Mastectomized Women","authors":"Joyce Souza Santana, Thamires Beatriz Belo Serrão, C. Dias, M. Paixão, C. Mendes, Breno Henrique Silva da Silva, Luciane Lobato Sobral Santos, Rodrigo Santiago Barbosa Rocha, Larissa Salgado de Oliveira Rocha","doi":"10.36648/1791-809X.21.15.824","DOIUrl":"https://doi.org/10.36648/1791-809X.21.15.824","url":null,"abstract":"Objective: To verify the influence of paramedical micro pigmentation on areolas on the quality of life of mastectomized women with breast reconstruction. Method: The study was conducted with fifteen volunteers with a mean age of 51.87 ± 12.13 years, submitted to mastectomy in an average time of 12.9± 35 months, followed by breast reconstruction with a mean time of 9.6± 9.91 months and who underwent the treatment of areolar paramedical micro pigmentation with an average time of 18.31 ± 10.45 months. In the micro pigmentation of the areolas was using the needle of one and three tips, with pigments. Later, they were evaluated by analysis of photographic images, by the Breast Cancer Scale - FACT-B. In addition, the volunteers answered a questionnaire that corresponded to the quality of life after breast reconstruction - EORTC QLQ - BRECON23. Descriptive analysis and the ANOVA test followed by Tukey (p<0.05) were used. Results: It was verified in the EORTC-BR23 questionnaire that the volunteers presented scores that indicated the side effects of treatment and symptoms at the place of withdrawal, low level of symptomatology or problems. However, for the scores satisfaction with the nipples and sexual function there was a low degree of satisfaction. Regarding the FACT-B questionnaire, in the additional concerns domain, an average value of 215.16 was observed, while the satisfaction of the volunteers was lower in the social/family well-being domains with significant mean values of 23.64, and functional well-being of 18.13 (p<0.05). Conclusion: It is concluded that micro pigmentation after breast reconstruction becomes acceptable with regard to the self-esteem of volunteers, allowing (re)inclusion in society for improvement of their self-esteem, self-image and thus promoting improvement in quality of life.","PeriodicalId":12868,"journal":{"name":"Health science journal","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85020409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/1791-809X.15.1.791
Bruno Caio Silva Souza, João Marcos Rodrigues de Lucena, Dhianey de Almeida Neves, L. Pereira, E. Barros, Laís Tonello, Elaine Vieira, R. M. Cunha, Fábio Santana, I. O. Silva
Introduction: Post Activation Potentiation (PAP) is the effect caused by a conditioning exercise with maximum or submaximal loads that promotes increased explosive strength in the subsequent activity. This phenomenon is due to the phosphorylation of light chain regulatory myosin manifesting in fast-twitch type II fibers. Electro-stimulation is a method that uses electric currents to promote involuntary muscle contraction, and its higher incidence in type II fibers because they have thicker and more superficial nerve endings. Objective: To compare the effects of an electro-stimulation protocol with a plyometric protocol to induce PAP on vertical jump performance. Methods: Plyometric Protocol (PP) - 2 sets of 10 ankle hops, 3 sets of 5 hundle hops, and 5 cold jumps. Electro-stimulation Protocol (EP) - Protocol 32 Neurodyn device 4 channels, Russian current, 90% of pain threshold with 3 "rise, 12" on, 3 "decay and 18" off with 70Hz frequency burst during 5 'and control condition (CC). 5 'after each protocol the Jump Power Test (JPT) was performed and 3' after the jump resistance test (RS). Results: Only the PP produced a significant effect when compared to the other protocols (p ≤ 0.05) PP+EP (290,49 ± 14,28 e 280,36 ± 10,26) (p=0.016) and PP+CC (290,49 ± 14,28 e 280,18 ± 12,07) (p=0.006). Regarding the% fatigue, the PP protocol had indices higher than the EP protocol (p=0.054) and CC (p=0.050). Conclusion: It was concluded that the electro-stimulation did not produce PAP effect nor in greater magnitude than the Plyometric protocol, but had the highest jump resistance compared to the control condition and plyometrics.
激活后增强(PAP)是由最大或次最大负荷的调节运动引起的效应,在随后的活动中促进爆炸强度的增加。这种现象是由于轻链调节肌球蛋白的磷酸化表现在快速收缩的II型纤维中。电刺激是一种利用电流促进不随意肌收缩的方法,它在II型纤维中发病率更高,因为它们有更厚、更浅的神经末梢。目的:比较电刺激方案和增力方案诱导PAP对垂直跳跃性能的影响。方法:增强训练方案(PP) - 2组10次踝跳,3组5百跳,5次冷跳。电刺激方案(EP) -方案32 Neurodyn装置4通道,俄罗斯电流,90%疼痛阈值3“上升,12”开,3“衰减和18”关,在5 '和控制条件(CC)期间70Hz频率突发。每个方案结束后5 '进行跳跃能力测试(JPT), 3'进行跳跃阻力测试(RS)。结果:只有PP与其他方案相比(p≤0.05)PP+EP(290,49±14,28 e 280,36±10,26)(p=0.016)和PP+CC(290,49±14,28 e 280,18±12,07)(p=0.006)有显著影响。在%疲劳指数方面,PP方案高于EP方案(p=0.054)和CC方案(p=0.050)。结论:电刺激不产生PAP效应,也不产生更大程度的PAP效应,但与对照和增强方案相比,电刺激具有最高的跳跃阻力。
{"title":"The Effect of Potentialization afterElectro-Stimulation Activation on VerticalHeel Performance","authors":"Bruno Caio Silva Souza, João Marcos Rodrigues de Lucena, Dhianey de Almeida Neves, L. Pereira, E. Barros, Laís Tonello, Elaine Vieira, R. M. Cunha, Fábio Santana, I. O. Silva","doi":"10.36648/1791-809X.15.1.791","DOIUrl":"https://doi.org/10.36648/1791-809X.15.1.791","url":null,"abstract":"Introduction: Post Activation Potentiation (PAP) is the effect caused by a conditioning exercise with maximum or submaximal loads that promotes increased explosive strength in the subsequent activity. This phenomenon is due to the phosphorylation of light chain regulatory myosin manifesting in fast-twitch type II fibers. Electro-stimulation is a method that uses electric currents to promote involuntary muscle contraction, and its higher incidence in type II fibers because they have thicker and more superficial nerve endings. Objective: To compare the effects of an electro-stimulation protocol with a plyometric protocol to induce PAP on vertical jump performance. Methods: Plyometric Protocol (PP) - 2 sets of 10 ankle hops, 3 sets of 5 hundle hops, and 5 cold jumps. Electro-stimulation Protocol (EP) - Protocol 32 Neurodyn device 4 channels, Russian current, 90% of pain threshold with 3 \"rise, 12\" on, 3 \"decay and 18\" off with 70Hz frequency burst during 5 'and control condition (CC). 5 'after each protocol the Jump Power Test (JPT) was performed and 3' after the jump resistance test (RS). Results: Only the PP produced a significant effect when compared to the other protocols (p ≤ 0.05) PP+EP (290,49 ± 14,28 e 280,36 ± 10,26) (p=0.016) and PP+CC (290,49 ± 14,28 e 280,18 ± 12,07) (p=0.006). Regarding the% fatigue, the PP protocol had indices higher than the EP protocol (p=0.054) and CC (p=0.050). Conclusion: It was concluded that the electro-stimulation did not produce PAP effect nor in greater magnitude than the Plyometric protocol, but had the highest jump resistance compared to the control condition and plyometrics.","PeriodicalId":12868,"journal":{"name":"Health science journal","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85211796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/1791-809X.21.15.844
Edy Parwanto
The SARS-CoV-2 genome consists of the: 5’ UTR, ORF 1ab gene, S gene, ORF 3a gene, E gene, M gene, ORF 6 gene, ORF 7a gene, ORF 7b gene, ORF 8 gene, N gene, ORF 10 gene and 3’ UTR. Gene mutations in SARS-CoV-2 can occur in all genes that make up the genome of SARS-CoV-2. Due to mutations in the SARS-CoV-2 gene, various variants of SARS-CoV-2 appear. Several variants of SARS-CoV-2 recorded since December 2020 include of B.1.1.7, B.1.351, B. 1.429, B.1.1.28, B.1.617 and B.1.618 variants. Due to the emergence of various variants of SARS-CoV-2, we must be more careful to avoid COVID-19. People who have co-morbidities of COVID-19 should be more careful to avoid COVID-19. We must continue to apply health protocols at the community level to prevent the transmission of SARS-CoV-2
{"title":"Genom and Gene Mutation of SARS-CoV-2","authors":"Edy Parwanto","doi":"10.36648/1791-809X.21.15.844","DOIUrl":"https://doi.org/10.36648/1791-809X.21.15.844","url":null,"abstract":"The SARS-CoV-2 genome consists of the: 5’ UTR, ORF 1ab gene, S gene, ORF 3a gene, E gene, M gene, ORF 6 gene, ORF 7a gene, ORF 7b gene, ORF 8 gene, N gene, ORF 10 gene and 3’ UTR. Gene mutations in SARS-CoV-2 can occur in all genes that make up the genome of SARS-CoV-2. Due to mutations in the SARS-CoV-2 gene, various variants of SARS-CoV-2 appear. Several variants of SARS-CoV-2 recorded since December 2020 include of B.1.1.7, B.1.351, B. 1.429, B.1.1.28, B.1.617 and B.1.618 variants. Due to the emergence of various variants of SARS-CoV-2, we must be more careful to avoid COVID-19. People who have co-morbidities of COVID-19 should be more careful to avoid COVID-19. We must continue to apply health protocols at the community level to prevent the transmission of SARS-CoV-2","PeriodicalId":12868,"journal":{"name":"Health science journal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84221561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/1791-809X.21.15.828
Shilei Wang, Jinlei Ye, Ying Chen, Z. Cui, Qiping Zheng, S. Shen, Lichun Sun
Gastric carcinoma is a refractory disease that seriously threatens human health globally. Unfortunately, its mortality is still high among common cancers. In order to develop a new type of anti-gastric cancer drug and avoid side effects of traditional chemotheray, a new drug-targeting strategy was considered in our studies. We firstly selected certain classic cytotoxic compounds such as ansamitocin P-3 (AP-3), colchicine and paclitaxel and investigated their efficacy in the suppression of gastric cancer cell growth and tumor growth. We found that these compounds displayed their potent suppressive activities. Particularly, AP-3 showed its significant tumor suppression in xenograft mouse model, and was also observed with its severe side effects. The results supported that AP-3 itself most likely was not druggable, but might be applied for drug conjugates via coupling it to a drug delivery vehicle to enhance its anti-tumor efficacy and reduce its side effects.
{"title":"The Potential Applications of the Potent Cytotoxic Ansamitocin P-3 in the Treatment of Gastric Carcinoma","authors":"Shilei Wang, Jinlei Ye, Ying Chen, Z. Cui, Qiping Zheng, S. Shen, Lichun Sun","doi":"10.36648/1791-809X.21.15.828","DOIUrl":"https://doi.org/10.36648/1791-809X.21.15.828","url":null,"abstract":"Gastric carcinoma is a refractory disease that seriously threatens human health globally. Unfortunately, its mortality is still high among common cancers. In order to develop a new type of anti-gastric cancer drug and avoid side effects of traditional chemotheray, a new drug-targeting strategy was considered in our studies. We firstly selected certain classic cytotoxic compounds such as ansamitocin P-3 (AP-3), colchicine and paclitaxel and investigated their efficacy in the suppression of gastric cancer cell growth and tumor growth. We found that these compounds displayed their potent suppressive activities. Particularly, AP-3 showed its significant tumor suppression in xenograft mouse model, and was also observed with its severe side effects. The results supported that AP-3 itself most likely was not druggable, but might be applied for drug conjugates via coupling it to a drug delivery vehicle to enhance its anti-tumor efficacy and reduce its side effects.","PeriodicalId":12868,"journal":{"name":"Health science journal","volume":"87 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91517678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/1791-809X.15.1.792
Pallavi Kaulwar
People living with pre- existing medical conditions (such as heart disease, diabetes and respiratory conditions) are at higher risk of complications and death due to COVID- 19 * In 2021 top priority is to achieve access to safe and effective vaccines, tests, and treatments and to make sure that health systems are strong enough to deliver them * Targets for the ACT- Accelerator in 2021 include: distributing 2 billion vaccines;245 million treatments;establishing testing for 500 million people in low and middle income countries;and strengthening the health systems needed to support them * Health organizations will endorse and reinforce the high quality, safety and efficacy of our own core technical functions, to provide globally with the best evidencebased recommendations for public health on issues ranging from Alzheimers to zika * Health Organization will confirm work with partners to enforce the new 10 year health map for Neglected Tropical Diseases (NTDs), with its global targets and milestones to prevent, control, knock out and extinguish 20 NTDs * And they will concentrate efforts to end AIDS, tuberculosis and malaria and to eliminate viral hepatitis by 2030 According to recent report globally COVID-19 has emphasized more than 93 8 million active cases, 51 7 million recoveries, 2 01 million deaths According to recent study, it's estimated that 1 in 15 adults will experience depression or have at least one major depressive episode According to report published in perspectives on psychological science
{"title":"A Meta- Analysis of various Medical Condition with Usability evaluation of Human Health Research Web Based Portal Study involving 500 Participants Data Analysis of Medical Condition","authors":"Pallavi Kaulwar","doi":"10.36648/1791-809X.15.1.792","DOIUrl":"https://doi.org/10.36648/1791-809X.15.1.792","url":null,"abstract":"People living with pre- existing medical conditions (such as heart disease, diabetes and respiratory conditions) are at higher risk of complications and death due to COVID- 19 * In 2021 top priority is to achieve access to safe and effective vaccines, tests, and treatments and to make sure that health systems are strong enough to deliver them * Targets for the ACT- Accelerator in 2021 include: distributing 2 billion vaccines;245 million treatments;establishing testing for 500 million people in low and middle income countries;and strengthening the health systems needed to support them * Health organizations will endorse and reinforce the high quality, safety and efficacy of our own core technical functions, to provide globally with the best evidencebased recommendations for public health on issues ranging from Alzheimers to zika * Health Organization will confirm work with partners to enforce the new 10 year health map for Neglected Tropical Diseases (NTDs), with its global targets and milestones to prevent, control, knock out and extinguish 20 NTDs * And they will concentrate efforts to end AIDS, tuberculosis and malaria and to eliminate viral hepatitis by 2030 According to recent report globally COVID-19 has emphasized more than 93 8 million active cases, 51 7 million recoveries, 2 01 million deaths According to recent study, it's estimated that 1 in 15 adults will experience depression or have at least one major depressive episode According to report published in perspectives on psychological science","PeriodicalId":12868,"journal":{"name":"Health science journal","volume":"8 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84569832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Importance: Coronavirus disease (COVID-19) is an infectious disease which caused by a newly discovered coronavirus. Objective: In this study we aimed to evaluation of burnout and job stress in care worker and comparison between front-line and second-line in care worker during coronavirus epidemic. Design, Settings, and Participants: This study is a cross-sectional, hospital-based survey conducted via a region-stratified, 2-stage cluster sampling from Sep 15, 2020, to Dec 10, 2020, The purpose of this research is applied research and in terms of survey method. The main tool used to collect information in this study is a questionnaire, which was also used to study the evidence to obtain human resource information Census method was used to determine the number of participants in the study. In this study, the researchers conducted their research on all people. They gave the questionnaire to all front-line care worker (nurse, assistant nurse, secretary) second-line care workers (Services, security, chefs and hostesses, facilities) of Jam Hospital, which was 537 people, and 342 questionnaires were filled in by the staff. Main Outcomes and Measures: We focused on symptoms of Job burnout and job stress in Jam Hospital staff. In this method, demographic data such as job, place of work, gender, age, level of education and work shifts were asked and two questionnaires were used. 1- COPSOQ Persian Questionnaire2- Stress assesses. Results: In the study, 537 health care workers were asked to participate, 342 respondents (63.6%) completed the survey (242 [70.7%] (front-line and) 100 [29.3%] (second-line). The occupational data of nonrespondents were similar to those of respondents. Most participants were women (207 [60.2%]), were aged 20 to 40 years (260 [76%]), had an educational level postgraduate (199 [58.1,were work night (193 [56.2%]), Of the 342 responding participants, 242 (70.7%) were front-line health care workers directly engaged in diagnosing, treating, or caring for patients with or suspected to have COVID-19 , and 100(29.3%) were socend-line. A considerable proportion of front-line participants had symptoms of occupational stress (P=0.03) & Job burnout) P=0.08). Job stress and burnout were higher in front-line staff who were in direct contact with patients with COVID 19 than in staff who were not in direct contact with the patient (P=0.02). There was no significant relationship between gender (P=0.5), education (P=0.3), job shift (P=0.06) and job stress and burnout.
{"title":"Evaluation of Burnout and Job Stress in Care Worker and Comparison between Front-Line and Second-Line in Care Worker during Coronavirus Epidemic","authors":"Niki Aghdam Babak Heidari Kabiri Sahra Sadeghipour","doi":"10.36648/1791-809X.21.S3.008","DOIUrl":"https://doi.org/10.36648/1791-809X.21.S3.008","url":null,"abstract":"Importance: Coronavirus disease (COVID-19) is an infectious disease which caused by a newly discovered coronavirus. Objective: In this study we aimed to evaluation of burnout and job stress in care worker and comparison between front-line and second-line in care worker during coronavirus epidemic. Design, Settings, and Participants: This study is a cross-sectional, hospital-based survey conducted via a region-stratified, 2-stage cluster sampling from Sep 15, 2020, to Dec 10, 2020, The purpose of this research is applied research and in terms of survey method. The main tool used to collect information in this study is a questionnaire, which was also used to study the evidence to obtain human resource information Census method was used to determine the number of participants in the study. In this study, the researchers conducted their research on all people. They gave the questionnaire to all front-line care worker (nurse, assistant nurse, secretary) second-line care workers (Services, security, chefs and hostesses, facilities) of Jam Hospital, which was 537 people, and 342 questionnaires were filled in by the staff. Main Outcomes and Measures: We focused on symptoms of Job burnout and job stress in Jam Hospital staff. In this method, demographic data such as job, place of work, gender, age, level of education and work shifts were asked and two questionnaires were used. 1- COPSOQ Persian Questionnaire2- Stress assesses. Results: In the study, 537 health care workers were asked to participate, 342 respondents (63.6%) completed the survey (242 [70.7%] (front-line and) 100 [29.3%] (second-line). The occupational data of nonrespondents were similar to those of respondents. Most participants were women (207 [60.2%]), were aged 20 to 40 years (260 [76%]), had an educational level postgraduate (199 [58.1,were work night (193 [56.2%]), Of the 342 responding participants, 242 (70.7%) were front-line health care workers directly engaged in diagnosing, treating, or caring for patients with or suspected to have COVID-19 , and 100(29.3%) were socend-line. A considerable proportion of front-line participants had symptoms of occupational stress (P=0.03) & Job burnout) P=0.08). Job stress and burnout were higher in front-line staff who were in direct contact with patients with COVID 19 than in staff who were not in direct contact with the patient (P=0.02). There was no significant relationship between gender (P=0.5), education (P=0.3), job shift (P=0.06) and job stress and burnout.","PeriodicalId":12868,"journal":{"name":"Health science journal","volume":"34 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86692157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/1791-809X.15.3.813
A. Dumitrescu, R. Cobzaru, C. Rîpă, Ana-Maria Slanina, R. Șufaru, M. Gavrilescu, E. Rezus, L. Gavril, A. Sava
The fetal posterior cerebral artery (f-PCA) is an anatomical variant of the circle of Willis, which was correlated with ischemic stroke, either ipsilateral, or controlateral. We present the case of a male 82-year old patient, who was admitted in the emergency care unit of the “Prof. Dr.N.Oblu” Emergency Clinical Hospital, Iasi, for a transient ischemic attack. The patient presented several comorbidities such as diabetes mellitus, hypertension stage 2, renal hydronephrosis, atrial fibrillation, and ischemic cardiomyopathy. His first submission to the emergency unit in 2014 had been due to an episode of transient ischemic attack, but after one year of not respecting his treatment and not willing to engage enough in occupational therapy procedures, he developed a second stroke, this time a large one, with secondary reperfusion, which lead to patient's death in a short time from his admission in our hospital. The autopsy revealed an asymmetrical circle of Willis due to the presence of a left fetal PCA and right hypoplastic posterior communicating artery (PComA) and a brain infarction with reperfusion of in the territory of the right PCA. Data from literature regardingthis particular type of paradoxal stroke and the coexistence of the two anatomical variants in the circle of Willis has been researched with the selection of 13 significant articles published in the period of the last 20 years.
{"title":"Paradoxical Stroke Related toAsymmetrical Circle of Willis - CasePresentation and Literature Review","authors":"A. Dumitrescu, R. Cobzaru, C. Rîpă, Ana-Maria Slanina, R. Șufaru, M. Gavrilescu, E. Rezus, L. Gavril, A. Sava","doi":"10.36648/1791-809X.15.3.813","DOIUrl":"https://doi.org/10.36648/1791-809X.15.3.813","url":null,"abstract":"The fetal posterior cerebral artery (f-PCA) is an anatomical variant of the circle of Willis, which was correlated with ischemic stroke, either ipsilateral, or controlateral. We present the case of a male 82-year old patient, who was admitted in the emergency care unit of the “Prof. Dr.N.Oblu” Emergency Clinical Hospital, Iasi, for a transient ischemic attack. The patient presented several comorbidities such as diabetes mellitus, hypertension stage 2, renal hydronephrosis, atrial fibrillation, and ischemic cardiomyopathy. His first submission to the emergency unit in 2014 had been due to an episode of transient ischemic attack, but after one year of not respecting his treatment and not willing to engage enough in occupational therapy procedures, he developed a second stroke, this time a large one, with secondary reperfusion, which lead to patient's death in a short time from his admission in our hospital. The autopsy revealed an asymmetrical circle of Willis due to the presence of a left fetal PCA and right hypoplastic posterior communicating artery (PComA) and a brain infarction with reperfusion of in the territory of the right PCA. Data from literature regardingthis particular type of paradoxal stroke and the coexistence of the two anatomical variants in the circle of Willis has been researched with the selection of 13 significant articles published in the period of the last 20 years.","PeriodicalId":12868,"journal":{"name":"Health science journal","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79440861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/1791-809X.21.15.839
Girum Fufa, Tilahun Ermeko, A. Mohammed, A. Lette
Objective: Community-based health insurance (CBHI) schemes are an emerging tool for providing financial protection against health-related poverty. In Ethiopia, CBHI is being piloted in 13 districts and expanded to 427 but community satisfaction with the scheme and health service delivery study have yet limited. Therefore, this study aimed to assess the satisfaction of CBHI client on the public health service they acquire. Methods: A facility based cross-sectional study design was conducted from March and April, 2019 in Arsi Nagele Woreda health centers. Three hundred ninety eight participants who visited the health care facility during the study period were included for quantitative and key informants interview were conducted.Data were entered in to and analyzed using SPSS version 22 and analyzed using descriptive and logistic regression model for quantitative and thematic analysis for qualitative study. Result: A total of 399 patients were participated in the study, yielding a response rate of 95% of which, 63.1 % were male, 24.4% of the clients were illiterates and almost 50% were from Kello Dure health center. The findings of the study showed that the overall client satisfaction level of CBHI with the health services received from the targeted health centers were 63.4% (95% CI=26.1-35.2). Clients who aged from 15-24 years [AOR=0.34 (95%CI=1.34-8.00)]. Those who have level of secondary education and above [AOR=0.45 (95% CI: 1.56-4.40)], waiting time at consultation area [AOR=0.68 (95% CI: 1.01-3.87)] and drugs availability [AOR=0.71 (95% CI: 2.15-10.30)]. Clients who were informed about service available at health facilities [AOR=2.11(95% CI: 1.29- 3.47)] were less likely unsatisfied with service delivered at health facilities. Qualitative research showed that the most unsatisfactory aspect for the CBHI clients on health service was lack of human power and Drugs. Conclusion and recommendation: This study showed higher clients’ satisfaction level in Arsi Negele district health facilities when compared to similar studies in the country. Young age, lack of drugs and supplies, poor information provision, long waiting time at consultation, was found to be the major causes of dissatisfaction. Therefore, the districthealth offices better to work on the quality of the service particularly around the waiting time of patient and health care provider interaction and drug accessibility.
{"title":"Assessing Factors Associated with Poor Community Based Health Insurance Client Satisfaction Level with Public Health Care Services in Negele Arsi Woreda Health Centers, West Arsi Zone Ethiopia","authors":"Girum Fufa, Tilahun Ermeko, A. Mohammed, A. Lette","doi":"10.36648/1791-809X.21.15.839","DOIUrl":"https://doi.org/10.36648/1791-809X.21.15.839","url":null,"abstract":"Objective: Community-based health insurance (CBHI) schemes are an emerging tool for providing financial protection against health-related poverty. In Ethiopia, CBHI is being piloted in 13 districts and expanded to 427 but community satisfaction with the scheme and health service delivery study have yet limited. Therefore, this study aimed to assess the satisfaction of CBHI client on the public health service they acquire. Methods: A facility based cross-sectional study design was conducted from March and April, 2019 in Arsi Nagele Woreda health centers. Three hundred ninety eight participants who visited the health care facility during the study period were included for quantitative and key informants interview were conducted.Data were entered in to and analyzed using SPSS version 22 and analyzed using descriptive and logistic regression model for quantitative and thematic analysis for qualitative study. Result: A total of 399 patients were participated in the study, yielding a response rate of 95% of which, 63.1 % were male, 24.4% of the clients were illiterates and almost 50% were from Kello Dure health center. The findings of the study showed that the overall client satisfaction level of CBHI with the health services received from the targeted health centers were 63.4% (95% CI=26.1-35.2). Clients who aged from 15-24 years [AOR=0.34 (95%CI=1.34-8.00)]. Those who have level of secondary education and above [AOR=0.45 (95% CI: 1.56-4.40)], waiting time at consultation area [AOR=0.68 (95% CI: 1.01-3.87)] and drugs availability [AOR=0.71 (95% CI: 2.15-10.30)]. Clients who were informed about service available at health facilities [AOR=2.11(95% CI: 1.29- 3.47)] were less likely unsatisfied with service delivered at health facilities. Qualitative research showed that the most unsatisfactory aspect for the CBHI clients on health service was lack of human power and Drugs. Conclusion and recommendation: This study showed higher clients’ satisfaction level in Arsi Negele district health facilities when compared to similar studies in the country. Young age, lack of drugs and supplies, poor information provision, long waiting time at consultation, was found to be the major causes of dissatisfaction. Therefore, the districthealth offices better to work on the quality of the service particularly around the waiting time of patient and health care provider interaction and drug accessibility.","PeriodicalId":12868,"journal":{"name":"Health science journal","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91161343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}