Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-134-136
A. Ermolaeva, G.K. Vladimirov, S. Gordleeva, A. Zaikin, P. S. Timashev
In this work, an integrated mathematical model of the liver cell, cholesterol metabolism, and drug interactions was developed. The model reproduced the well-known biology of cholesterol regulation, which confirms its potential for minimizing cellular research in the initial testing of new drugs for cardiology.
{"title":"DIGITAL MODELING OF IN VITRO RESEARCH","authors":"A. Ermolaeva, G.K. Vladimirov, S. Gordleeva, A. Zaikin, P. S. Timashev","doi":"10.37747/2312-640x-2021-19-134-136","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-134-136","url":null,"abstract":"In this work, an integrated mathematical model of the liver cell, cholesterol metabolism, and drug interactions was developed. The model reproduced the well-known biology of cholesterol regulation, which confirms its potential for minimizing cellular research in the initial testing of new drugs for cardiology.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"224 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85559679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-142-144
V. Skripova, L. Bulatova, D. Savenkova, A. K. Nurgalieva, R. Vlasenkova, D. Reshetnikova, A. Timonina, M. Bogdanov
Using CRISPR/Cas9 and SEREX technologies we have identified and characterized more than two hundred potential molecular markers of oncological diseases. It was shown that the sodium-dependent phosphate transporter NaPi2b is a unique target for the development of antitumor targeted drugs due to its localization and tumor-specific epitope.
{"title":"MOLECULAR MARKERS FOR CANCER DIAGNOSIS AND THERAPY","authors":"V. Skripova, L. Bulatova, D. Savenkova, A. K. Nurgalieva, R. Vlasenkova, D. Reshetnikova, A. Timonina, M. Bogdanov","doi":"10.37747/2312-640x-2021-19-142-144","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-142-144","url":null,"abstract":"Using CRISPR/Cas9 and SEREX technologies we have identified and characterized more than two hundred potential molecular markers of oncological diseases. It was shown that the sodium-dependent phosphate transporter NaPi2b is a unique target for the development of antitumor targeted drugs due to its localization and tumor-specific epitope.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82579207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-207-209
K. Gorbunov
For any weighted directed chain-cycle graphs a and b (referred to as structures) and any equal costs of operations (intermergings and duplication), we obtain an algorithm which, by successively applying these operations to a, outputs b if the first structure contains no paralogs (edges with a repeated name) and the second has no more than two paralogs for each edge. The algorithm has a multiplicative error of at most 13/9 + ε, where ε is any strictly positive number, and its runtime is of the order of no(ε–2.6), where n is the size of the initial pair of graphs. We also obtain algorithms for reconstruction of the evolution of genome structures with a condition on ancestor structures and along the phylogenetic tree.
{"title":"RECONSTRUCTION OF EVOLUTION OF GENOME STRUCTURES WITH PARALOGS","authors":"K. Gorbunov","doi":"10.37747/2312-640x-2021-19-207-209","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-207-209","url":null,"abstract":"For any weighted directed chain-cycle graphs a and b (referred to as structures) and any equal costs of operations (intermergings and duplication), we obtain an algorithm which, by successively applying these operations to a, outputs b if the first structure contains no paralogs (edges with a repeated name) and the second has no more than two paralogs for each edge. The algorithm has a multiplicative error of at most 13/9 + ε, where ε is any strictly positive number, and its runtime is of the order of no(ε–2.6), where n is the size of the initial pair of graphs. We also obtain algorithms for reconstruction of the evolution of genome structures with a condition on ancestor structures and along the phylogenetic tree.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89912790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-132-133
T. Gamilov, S. Simakov, G. V. Kopytov, P. Kopylov, D. Gognieva
A digital technology for assessing the fractional flow reserve, a key diagnostic characteristic of coronary artery stenosis, has been developed and validated. The technology has a sufficiently high level of accuracy and can be used in real clinical practice in order to increase the diagnostic efficiency of routine computed tomography of the coronary arteries.
{"title":"COMPUTATIONAL TECHNOLOGY FOR NON-INVASIVE DIAGNOSIS OF CORONARY ARTERY STENOSIS\u0000IN PATIENTS WITH ISCHEMIC HEART DISEASE","authors":"T. Gamilov, S. Simakov, G. V. Kopytov, P. Kopylov, D. Gognieva","doi":"10.37747/2312-640x-2021-19-132-133","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-132-133","url":null,"abstract":"A digital technology for assessing the fractional flow reserve, a key diagnostic characteristic of coronary artery stenosis, has been developed and validated. The technology has a sufficiently high level of accuracy and can be used in real clinical practice in order to increase the diagnostic efficiency of routine computed tomography of the coronary arteries.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90118590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-282-284
A. Pustovgar
This paper describes the use of biocatalytic technologies in construction and housing and communal services. Special attention is paid to the use of microbiological processes for the modification of soil bases, concretes and building mortars. The problems and directions of future research in this area are considered.
{"title":"BIOCATALYTIC TECHNOLOGIES IN CONSTRUCTION AND HOUSING AND COMMUNAL SERVICES: APPLICATION AND PROSPECTS","authors":"A. Pustovgar","doi":"10.37747/2312-640x-2021-19-282-284","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-282-284","url":null,"abstract":"This paper describes the use of biocatalytic technologies in construction and housing and communal services. Special attention is paid to the use of microbiological processes for the modification of soil bases, concretes and building mortars. The problems and directions of future research in this area are considered.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91154971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-244-246
O. Bodulev, A. Soloviev
This work will present the results of the development of two new highly sensitive heterogeneous methods for the determination of miRNA-141 and miRNA-39 using the isothermal circular strand-displacement amplification and the catalytic hairpin assembly methods for analyte amplification.
{"title":"HIGHLY SENSITIVE METHODS FOR MICRORNA DETECTION USING ISOTHERMAL METHODS FOR NUCLEIC ACIDS AMPLIFICATION","authors":"O. Bodulev, A. Soloviev","doi":"10.37747/2312-640x-2021-19-244-246","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-244-246","url":null,"abstract":"This work will present the results of the development of two new highly sensitive heterogeneous methods for the determination of miRNA-141 and miRNA-39 using the isothermal circular strand-displacement amplification and the catalytic hairpin assembly methods for analyte amplification.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80879557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-158-159
Z. Sagirova, N. Kuznetsova, I. Zakharov, A. Suvorov, V. Larionov, P. Kopylov
When using a single-channel ECG and FPG, it was possible to assess systolic and diastolic dysfunction of the left ventricle of various degrees with high accuracy
使用单通道ECG和FPG，可以准确评估不同程度的左心室收缩和舒张功能障碍
{"title":"THE POSSIBILITIES OF ARTIFICIAL INTELLIGENCE IN THE REMOTE ASSESSMENT OF THE PARAMETERS OF THE CARDIOVASCULAR SYSTEM","authors":"Z. Sagirova, N. Kuznetsova, I. Zakharov, A. Suvorov, V. Larionov, P. Kopylov","doi":"10.37747/2312-640x-2021-19-158-159","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-158-159","url":null,"abstract":"When using a single-channel ECG and FPG, it was possible to assess systolic and diastolic dysfunction of the left ventricle of various degrees with high accuracy","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78723638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-88-90
Chitosan-covered calcium phosphate particles are promising carriers for the delivery of low-molecular-weight drugs to ocular tissues. The inclusion of the angiotensin-converting enzyme inhibitor enalaprilat into these particles increases the retention time of the drug in the tear, enhances the effectiveness of intraocular pressure decrease, and prolongs the drug action.
{"title":"CHITOSAN-COATED CALCIUM PHOSPHATE PARTICLES AS CARRIERS FOR DRUG DELIVERY TO OCULAR TISSUES","authors":"","doi":"10.37747/2312-640x-2021-19-88-90","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-88-90","url":null,"abstract":"Chitosan-covered calcium phosphate particles are promising carriers for the delivery of low-molecular-weight drugs to ocular tissues. The inclusion of the angiotensin-converting enzyme inhibitor enalaprilat into these particles increases the retention time of the drug in the tear, enhances the effectiveness of intraocular pressure decrease, and prolongs the drug action.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79201200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-383-385
D.M. Smolyaninova, E. V. Bizina, M. Larina, T. Ermolaeva
Piezoelectric gravimetric sensors based on magnetic nanocomposites: polymers with molecular imprints (MIP) Fe3O4@MIP N - (phosphonmethyl) - glycine have been developed. It was found that the optimal concentration ratio of template: functional monomer: cross-monomer is 1: 3: 25. The best synthesis time is 3h with constant stirring at a speed of 60 rpm and heating to 60 °C.
基于磁性纳米复合材料的压电式重力传感器:分子印迹聚合物(MIP) Fe3O4@MIP N -(磷甲基)-甘氨酸。结果表明，模板、功能单体、交叉单体的最佳浓度比为1:3:25。最佳合成时间为3h，转速为60rpm，加热至60℃。
{"title":"MAGNETIC NANOCOMPOSITES IN PIEZOELECTRIC SENSORS FOR DETERMINATION OF GLYPHOSATE","authors":"D.M. Smolyaninova, E. V. Bizina, M. Larina, T. Ermolaeva","doi":"10.37747/2312-640x-2021-19-383-385","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-383-385","url":null,"abstract":"Piezoelectric gravimetric sensors based on magnetic nanocomposites: polymers with molecular imprints (MIP) Fe3O4@MIP N - (phosphonmethyl) - glycine have been developed. It was found that the optimal concentration ratio of template: functional monomer: cross-monomer is 1: 3: 25. The best synthesis time is 3h with constant stirring at a speed of 60 rpm and heating to 60 °C.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73354264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-236-238
G. Kutdusova, E. Suprun
Deoxyuridine triphosphates modified with tyrosine or tryptophan aromatic groups were tested as electroactive ‘labels’ for the electrochemical detection of double-stranded DNA amplicons obtained by recombinase polymerase amplification.
{"title":"DEOXYURIDINE TRIPHOSPHATES MODIFIED WITH AROMATIC TYROSINE GROUPS FOR ELECTROCHEMICAL DETERMINATION OF RECOMBINASE POLYMERASE AMPLIFICATION PRODUCTS OF DNA","authors":"G. Kutdusova, E. Suprun","doi":"10.37747/2312-640x-2021-19-236-238","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-236-238","url":null,"abstract":"Deoxyuridine triphosphates modified with tyrosine or tryptophan aromatic groups were tested as electroactive ‘labels’ for the electrochemical detection of double-stranded DNA amplicons obtained by recombinase polymerase amplification.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80155478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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