Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-207-209
K. Gorbunov
For any weighted directed chain-cycle graphs a and b (referred to as structures) and any equal costs of operations (intermergings and duplication), we obtain an algorithm which, by successively applying these operations to a, outputs b if the first structure contains no paralogs (edges with a repeated name) and the second has no more than two paralogs for each edge. The algorithm has a multiplicative error of at most 13/9 + ε, where ε is any strictly positive number, and its runtime is of the order of no(ε–2.6), where n is the size of the initial pair of graphs. We also obtain algorithms for reconstruction of the evolution of genome structures with a condition on ancestor structures and along the phylogenetic tree.
{"title":"RECONSTRUCTION OF EVOLUTION OF GENOME STRUCTURES WITH PARALOGS","authors":"K. Gorbunov","doi":"10.37747/2312-640x-2021-19-207-209","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-207-209","url":null,"abstract":"For any weighted directed chain-cycle graphs a and b (referred to as structures) and any equal costs of operations (intermergings and duplication), we obtain an algorithm which, by successively applying these operations to a, outputs b if the first structure contains no paralogs (edges with a repeated name) and the second has no more than two paralogs for each edge. The algorithm has a multiplicative error of at most 13/9 + ε, where ε is any strictly positive number, and its runtime is of the order of no(ε–2.6), where n is the size of the initial pair of graphs. We also obtain algorithms for reconstruction of the evolution of genome structures with a condition on ancestor structures and along the phylogenetic tree.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89912790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-132-133
T. Gamilov, S. Simakov, G. V. Kopytov, P. Kopylov, D. Gognieva
A digital technology for assessing the fractional flow reserve, a key diagnostic characteristic of coronary artery stenosis, has been developed and validated. The technology has a sufficiently high level of accuracy and can be used in real clinical practice in order to increase the diagnostic efficiency of routine computed tomography of the coronary arteries.
{"title":"COMPUTATIONAL TECHNOLOGY FOR NON-INVASIVE DIAGNOSIS OF CORONARY ARTERY STENOSIS\u0000IN PATIENTS WITH ISCHEMIC HEART DISEASE","authors":"T. Gamilov, S. Simakov, G. V. Kopytov, P. Kopylov, D. Gognieva","doi":"10.37747/2312-640x-2021-19-132-133","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-132-133","url":null,"abstract":"A digital technology for assessing the fractional flow reserve, a key diagnostic characteristic of coronary artery stenosis, has been developed and validated. The technology has a sufficiently high level of accuracy and can be used in real clinical practice in order to increase the diagnostic efficiency of routine computed tomography of the coronary arteries.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90118590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-331-332
S. Belenkaya, V. V. Elchaninov
A plasmid vector pSVB was developed, which allows integrating an expression cassette containing the maral prochymosin gene into the genome of the yeast Kluyveromyces lactis. Producer strains have been obtained that ensure the accumulation of recombinant maral chymosin in the culture medium with a milk-clotting activity of up to 145 AU / ml.
建立了一种质粒载体pSVB，将含有酵母原凝乳酶基因的表达盒整合到酵母的基因组中。已经获得了生产菌株，确保在培养基中积累重组马尔凝乳酶，凝乳活性高达145 AU / ml。
{"title":"DEVELOPMENT OF A PRODUCER OF RECOMBINANT MARAL CHYMOSIN BASED ON THE YEAST KLUYVEROMYCES LACTIS","authors":"S. Belenkaya, V. V. Elchaninov","doi":"10.37747/2312-640x-2021-19-331-332","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-331-332","url":null,"abstract":"A plasmid vector pSVB was developed, which allows integrating an expression cassette containing the maral prochymosin gene into the genome of the yeast Kluyveromyces lactis. Producer strains have been obtained that ensure the accumulation of recombinant maral chymosin in the culture medium with a milk-clotting activity of up to 145 AU / ml.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85161838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-322-324
E. Zvereva, A. Zherdev, B. Dzantiev
Methods have been developed to control the content of non-meat components (connective tissue of animals, eggs, soy) in processed meat products, based on enzyme immunoassay of biomarker proteins – collagen, ovalbumin, soybean trypsin inhibitor.
{"title":"DEVELOPMENT OF IMMUNOENZYME ANALYTICAL SYSTEMS FOR CONTROL OF THE CONTENT OF MAIN NON-MEAT COMPOUNDS IN PROCESSED MEAT PRODUCTS","authors":"E. Zvereva, A. Zherdev, B. Dzantiev","doi":"10.37747/2312-640x-2021-19-322-324","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-322-324","url":null,"abstract":"Methods have been developed to control the content of non-meat components (connective tissue of animals, eggs, soy) in processed meat products, based on enzyme immunoassay of biomarker proteins – collagen, ovalbumin, soybean trypsin inhibitor.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"99 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81300430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-69-70
Y. Zorkina, E. Zubkov, V. Ushakova, A. Morozova
Prenatal stress induced by exposure to variable ultrasound has been demonstrated to induce anxious behavior and change social preferences in the rat offspring at juvenile age.
暴露于可变超声诱发的产前应激已被证明可诱发幼年大鼠后代的焦虑行为和改变社会偏好。
{"title":"EARLY BEHAVIORAL DISORDERS IN RATS UNDER THE INFLUENCE OF CHRONIC PRENATAL STRESS","authors":"Y. Zorkina, E. Zubkov, V. Ushakova, A. Morozova","doi":"10.37747/2312-640x-2021-19-69-70","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-69-70","url":null,"abstract":"Prenatal stress induced by exposure to variable ultrasound has been demonstrated to induce anxious behavior and change social preferences in the rat offspring at juvenile age.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81323160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-22-24
A. Nechaev, P. Eremin, I. Gilmutdinova
The paper presents the results of the development of a bioactive bioplastic material (BIO) based on ion-track wound coatings (ITRP) and a nano-scaffold of chitosan obtained by electroforming. The water and gas permeability, the ultimate strength, bacteriostaticity, cytotoxicity and biocompatibility of BIO ITPR were investigated.
{"title":"BIOACTIVE BIOPLASTIC MATERIAL BASED ON ION-TRACK WOUND COATINGS AND CHITOSAN NANO-SCAFFOLD","authors":"A. Nechaev, P. Eremin, I. Gilmutdinova","doi":"10.37747/2312-640x-2021-19-22-24","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-22-24","url":null,"abstract":"The paper presents the results of the development of a bioactive bioplastic material (BIO) based on ion-track wound coatings (ITRP) and a nano-scaffold of chitosan obtained by electroforming. The water and gas permeability, the ultimate strength, bacteriostaticity, cytotoxicity and biocompatibility of BIO ITPR were investigated.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88108109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-158-159
Z. Sagirova, N. Kuznetsova, I. Zakharov, A. Suvorov, V. Larionov, P. Kopylov
When using a single-channel ECG and FPG, it was possible to assess systolic and diastolic dysfunction of the left ventricle of various degrees with high accuracy
使用单通道ECG和FPG，可以准确评估不同程度的左心室收缩和舒张功能障碍
{"title":"THE POSSIBILITIES OF ARTIFICIAL INTELLIGENCE IN THE REMOTE ASSESSMENT OF THE PARAMETERS OF THE CARDIOVASCULAR SYSTEM","authors":"Z. Sagirova, N. Kuznetsova, I. Zakharov, A. Suvorov, V. Larionov, P. Kopylov","doi":"10.37747/2312-640x-2021-19-158-159","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-158-159","url":null,"abstract":"When using a single-channel ECG and FPG, it was possible to assess systolic and diastolic dysfunction of the left ventricle of various degrees with high accuracy","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78723638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-134-136
A. Ermolaeva, G.K. Vladimirov, S. Gordleeva, A. Zaikin, P. S. Timashev
In this work, an integrated mathematical model of the liver cell, cholesterol metabolism, and drug interactions was developed. The model reproduced the well-known biology of cholesterol regulation, which confirms its potential for minimizing cellular research in the initial testing of new drugs for cardiology.
{"title":"DIGITAL MODELING OF IN VITRO RESEARCH","authors":"A. Ermolaeva, G.K. Vladimirov, S. Gordleeva, A. Zaikin, P. S. Timashev","doi":"10.37747/2312-640x-2021-19-134-136","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-134-136","url":null,"abstract":"In this work, an integrated mathematical model of the liver cell, cholesterol metabolism, and drug interactions was developed. The model reproduced the well-known biology of cholesterol regulation, which confirms its potential for minimizing cellular research in the initial testing of new drugs for cardiology.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"224 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85559679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-358-359
E. Kotenkova
White and brown adipose tissue is present in the human body and is well described. As well as the effect of the type of fat on human health, in particular obesity, type 2 diabetes, insulin tolerance. The presence and distribution of different types of fat in pigs has not been adequately described. As well as the factors contributing to the "browning" of white fat and the ability to influence this process in pigs.
{"title":"ADIPOGENESIS FEATURES OF WHITE, BEIGE AND BROWN ADIPOSE TISSUES","authors":"E. Kotenkova","doi":"10.37747/2312-640x-2021-19-358-359","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-358-359","url":null,"abstract":"White and brown adipose tissue is present in the human body and is well described. As well as the effect of the type of fat on human health, in particular obesity, type 2 diabetes, insulin tolerance. The presence and distribution of different types of fat in pigs has not been adequately described. As well as the factors contributing to the \"browning\" of white fat and the ability to influence this process in pigs.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91040897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.37747/2312-640x-2021-19-282-284
A. Pustovgar
This paper describes the use of biocatalytic technologies in construction and housing and communal services. Special attention is paid to the use of microbiological processes for the modification of soil bases, concretes and building mortars. The problems and directions of future research in this area are considered.
{"title":"BIOCATALYTIC TECHNOLOGIES IN CONSTRUCTION AND HOUSING AND COMMUNAL SERVICES: APPLICATION AND PROSPECTS","authors":"A. Pustovgar","doi":"10.37747/2312-640x-2021-19-282-284","DOIUrl":"https://doi.org/10.37747/2312-640x-2021-19-282-284","url":null,"abstract":"This paper describes the use of biocatalytic technologies in construction and housing and communal services. Special attention is paid to the use of microbiological processes for the modification of soil bases, concretes and building mortars. The problems and directions of future research in this area are considered.","PeriodicalId":13077,"journal":{"name":"http://eng.biomos.ru/conference/articles.htm","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91154971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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