Indian Journal of Medical Microbiology最新文献

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Effectiveness of rotavirus vaccine following introduction in the childhood immunization program in Northeast India

IF 1.4 4区医学 Q4 IMMUNOLOGY

Indian Journal of Medical Microbiology

Pub Date : 2025-01-01 DOI: 10.1016/j.ijmmb.2025.100794

Thingnam Binita Devi , Heigrujam Rebachandra Singh , Chongtham Shyamsunder Singh , Khuraijam Ranjana Devi , Shakti Laishram

Background

Rotavirus diarrhoea is a major cause of mortality and morbidity in children under five years of age. The WHO has recommended vaccination against this agent especially in countries with high mortality rates. As India accounts for almost a quarter of worldwide rotaviral diarrhoea cases, the government has introduced indigenously manufactured vaccines in the national immunization schedule which has been implemented in four phases. This study was conducted to assess the effectiveness of the vaccine used in the national immunization program in the state of Manipur in North-east India.

Methods

A test negative study design was used comparing rotavirus positive diarrhoeal children to rotavirus negative diarrhoeal children. All children ≤5 years presenting with acute diarrhoea were enrolled in the study and antigen detection enzyme-immuno assay was done to detect presence of rotavirus. All rotavirus positive patients were taken as cases and compared with rotavirus negative controls.

Results

63 rotavirus positive cases and 121 rotavirus negative controls were enrolled in the study. Vaccination rate among cases was significantly lower than controls (31.7 % vs 68.6 %, p < .001). Vaccine effectiveness of completed vaccination series was found to be 94 % against rotaviral infection and 98.1 % against severe disease and need for hospitalization.

Conclusion

Current rotaviral vaccine used in the national immunization schedule of India is effective in preventing rotaviral diarrhoea in the state of Manipur. Sustained vaccination will reduce the mortality and morbidity of rotaviral diarrhoea in this region.

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引用次数: 0

A case of Vibrio pelagius in a child with inflammatory bowel disease 炎症性肠病患儿感染伯氏弧菌1例。

IF 1.4 4区医学 Q4 IMMUNOLOGY

Indian Journal of Medical Microbiology

Pub Date : 2025-01-01 DOI: 10.1016/j.ijmmb.2024.100783

Akhila R. Mohan , Priya Sree Balaji , Nayannika Lakra , Ramya Srinivasa Rangan , Tamil Selvan , Jharna Mandal

We describe a rare case of an eleven-year-old child with undiagnosed underlying Crohn's disease who contracted Vibrio pelagius. Though the exact source remained undetermined, the child may have acquired it through infected sea food. Automated system failed to exactly identify the isolated organism; we used detailed biochemical tests for identification. Early diagnosis and identification allowed for efficient treatment plan and the clinical improvement of the child. This case report will give insight to clinical microbiologists for identifying such uncommon bacteria by using biochemical assays in addition to automated systems especially, in those with underlying bowel illnesses.

我们描述了一个罕见的情况下，一个11岁的孩子与未确诊的潜在克罗恩病谁感染了伯拉格弧菌。虽然确切的来源仍未确定，但这名儿童可能是通过受感染的海鲜感染的。自动化系统无法准确识别分离的生物；我们使用了详细的生化测试进行鉴定。早期诊断和识别有助于制定有效的治疗计划和改善儿童的临床状况。本病例报告将为临床微生物学家提供见解，通过使用生化分析和自动化系统来识别这种罕见的细菌，特别是在那些有潜在肠道疾病的患者中。

引用次数: 0

Fungal nasal polyposis – A rare case report 真菌性鼻息肉病1例报告。

IF 1.4 4区医学 Q4 IMMUNOLOGY

Indian Journal of Medical Microbiology

Pub Date : 2025-01-01 DOI: 10.1016/j.ijmmb.2024.100768

Jaishma Rajni Jeyaraaj, Latha Ragunathan, Kavitha kanniyan, Pramodhini Subramanian, Sherief Shebeena, Mohamed Asarudeen, Jenifer Raj Robin

Aspergillus peyronelii is an emerging and rare pathogen causing chronic rhinosinusitis with fungal nasal polyposis among immunocompetent individuals. Usual fungal aetiologies are Aspergillus spp, Mucor spp and Cladosporium spp, among which Aspergillus flavus being the most common in India. We present a case of 28-year-old woman with unilateral nasal obstruction with 15 years history of allergy, diagnosed as nasal polyposis, uncovered an uncommon pathogen A.peyronelii. Being a saprophytic and endophytic fungus, meticulously diagnostic approaches were employed for the precise identification. Further researches are needed to optimize diagnostic strategies and therapeutic intervention of this species.

peyronelaspergillus peyronelii是一种新出现的罕见病原体，在免疫功能正常的个体中引起慢性鼻窦炎并真菌性鼻息肉病。常见的病原真菌有曲霉、毛霉和枝孢菌，其中黄曲霉在印度最为常见。我们报告一例28岁的女性，有15年的过敏史，单侧鼻塞，诊断为鼻息肉病，发现了一种罕见的病原体。作为腐生和内生真菌，采用细致的诊断方法进行精确鉴定。需要进一步的研究来优化该物种的诊断策略和治疗干预。

引用次数: 0

Identification of dengue virus serotype and genotype: A comprehensive study from AIIMS Patna, Bihar

IF 1.4 4区医学 Q4 IMMUNOLOGY

Indian Journal of Medical Microbiology

Pub Date : 2025-01-01 DOI: 10.1016/j.ijmmb.2025.100789

Kamal Singh , Md Zeeshan Farooque , Vikram Pal Gandhi, Apurva, Aman Kumar, Asim Sarfraz, Binod Kumar Pati

Purpose

Dengue virus, a major global health concern, exhibits significant genetic diversity, leading to distinct serotypes and genotypes. Dengue is the second most common disease spread by mosquitoes that infect humans, after malaria. In recent decades, there has also been a shift in the tendencies of virus transmission from urban to peri-urban and rural settings. This research study focuses on the identification and characterization of dengue virus serotypes and genotypes.

Methods

In this study, specimens collected in one year were first subjected to serological assay (NS1 and IgM) and subsequently the NS1 positive samples were subjected to identification and characterization of the prevalent dengue virus serotypes and genotypes.

Results

During the year 2021, a total of 933serum samples were tested, out of which 75 were found positive for NS1 antigen and 135 were positive for Dengue IgM antibody by ELISA. The dengue serotype specific Real-Time RT-PCR Assay detected all four serotypes in the NS1-positive samples, indicating their presence in this region. Of these, DEN-1 was detected in 4 (7.8 %), DEN-2 in 26 (50.9 %), DEN-3 in 20 (39 %), DEN-4 in 1 (1.9 %). Out of 51Real‐Time RT‐PCR positive samples, 33 were found positive by conventional PCR for genotyping by targeting the capsid-preMembrane (C-prM)region. The genotyping result showed that DENV-1 serotype clustering with GIII, DEN-2 serotype clustering withwide range of genotypes such as IVa, IVb, and IVc, DEN-3 clustering with GIII genotype and DEN-4 serotype showed GIII genotype.

Conclusions

This study provides the recent details about the circulating serotypes along with prevalent genotypes in this region.

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引用次数: 0

Triple soil transmitted helminths in a case of aluminium phosphide poisoning 在一起磷化铝中毒案件中，三层土壤传播了蠕虫。

IF 1.4 4区医学 Q4 IMMUNOLOGY

Indian Journal of Medical Microbiology

Pub Date : 2025-01-01 DOI: 10.1016/j.ijmmb.2024.100787

Abhishek Mewara, Mamta Thakur, Sana Afreen, Nikita Sharma, Sumeeta Khurana

Soil transmitted helminth (STH) infections remain prevalent in India despite the ongoing deworming program. Here, we report a case of triple infection of Ascaris lumbricoides, Ancylostoma duodenale, and Strongyloides stercoralis, in a young asymptomatic and apparently immunocompetent female presenting with aluminium phosphide poisoning. Except for severe anaemia, the only other indicators of chronic infection were occasional abdominal pain and self-limiting loose stools. She was successfully treated for her conditions. This case highlights that despite regular deworming programs in children, STH may continue to infect adults in endemic areas and may be relevant to their well-being.

尽管正在进行除虫计划，土壤传播的蠕虫（STH）感染在印度仍然普遍存在。在这里，我们报告一个病例三重感染蛔虫类，十二指肠钩虫，和粪圆形线虫，在一个年轻的无症状和明显免疫能力的女性表现为磷化铝中毒。除严重贫血外，慢性感染的唯一其他指标是偶尔的腹痛和自限性稀便。她的病情得到了成功的治疗。这个案例强调，尽管定期为儿童驱虫，但STH可能会继续感染流行地区的成年人，并可能与他们的福祉有关。

引用次数: 0

The Wolf in Sheep's Clothing: Incidental Pulmonary Hydatidosis masquerading as Constitutional Symptoms

IF 1.4 4区医学 Q4 IMMUNOLOGY

Indian Journal of Medical Microbiology

Pub Date : 2025-01-01 DOI: 10.1016/j.ijmmb.2025.100792

Debasish Biswal , Suchitra Shenoy M , Bergin C , Udaya Sureshkumar , Vishak Acharya K , Madhav Kamath M , Shrikala Baliga

Hydatid disease, caused by Echinococcus granulosus, remains a significant health concern in endemic regions. This case report aims to highlight the diagnostic challenges of pulmonary hydatid cysts in non-endemic areas, presenting a unique case of an incidental pulmonary hydatid cyst in a 31-year-old lactating female discovered during evaluation of non-specific constitutional symptoms.

引用次数: 0

Digital gangrene without sclerodactyly in the presence of anticentromere antibodies: A unique presentation of scleroderma 抗着丝粒抗体存在下无硬指的指性坏疽：硬皮病的一种独特表现。

IF 1.4 4区医学 Q4 IMMUNOLOGY

Indian Journal of Medical Microbiology

Pub Date : 2025-01-01 DOI: 10.1016/j.ijmmb.2024.100769

Urvashi Suman, Lata Sheoran, Vikas Manchanda, Sonal Saxena

Peripheral vascular disorders associated with anti-centromere antibody (ACA) present generally with sclerodactyly in connective tissue disorders (CTD). It is unusual for ACA-associated digital necrosis to develop without preexisting raynaud's phenomena or vascular risk factors. We report a novel case of a 60-year-old non-smoker, non-diabetic woman with ACA and isolated finger necrosis without any other features of CTD. This case underscores the importance of considering an autoimmune contribution to the development of digital necrosis even without any identifiable CTD. It highlights the need to consider ACA-associated digital gangrene to be considered as a distinct entity of an autoimmune disorder from scleroderma.

结缔组织疾病（CTD）中，与抗着丝粒抗体（ACA）相关的周围血管疾病通常伴有硬化。在没有雷诺氏现象或血管危险因素的情况下，aca相关的指部坏死是很少见的。我们报告一个60岁的非吸烟，非糖尿病女性ACA和孤立的手指坏死没有任何其他特征的CTD。本病例强调了考虑自身免疫对指骨坏死发展的重要性，即使没有任何可识别的CTD。它强调需要考虑aca相关的指坏疽被视为硬皮病自身免疫性疾病的一个不同的实体。

引用次数: 0

Mycoplasma pneumoniae among children hospitalized in a tertiary hospital with community-acquired lower respiratory tract infections 一家三级医院中因社区获得性下呼吸道感染而住院的儿童中的肺炎支原体。

IF 1.4 4区医学 Q4 IMMUNOLOGY

Indian Journal of Medical Microbiology

Pub Date : 2025-01-01 DOI: 10.1016/j.ijmmb.2024.100781

Surinder Kumar , Sanjeev R. Saigal , Sourabh Kumar , G.R. Sethi

Purpose

In this prospective study incidence of Mycoplasma pneumoniae (M. pneumoniae) infection was investigated in children with community-aquired lower respiratory tract infections (LRTIs) using methods such as serology, nested PCR (polymerase chain reaction), and multiplex PCR analysis.

Methods

M. pneumoniae infection was investigated among 200 children with LRTIs, ages 2 months to 12 years,. Blood samples were taken for M. pneumoniae antibodies both during admission and four to six weeks following enrollment. Nested and multiplex PCR analysis was performed to identify M. pneumoniae from nasopharyngeal aspirates (NPAs).

Results

Infection due to M. pneumoniae was noted in 29 children (74.35 %) < 5 years of age and in 10 children (25.65 %) aged ≥5 years. The relationship between M. pneumoniae and age was statistically significant in the age group of children under five years [P = 0.004]. No statistically significant difference was seen between male and female children [P = 0.91]. Clinical and radiological results and M pneumoniae infection did not demonstrate any statistically significant correlation with the exception of the presence of statistically significant infiltrates (P = 0.04). In 39 (19.5 %) children, M. pneumoniae was found using a combination of multiplex PCR, nested PCR, and serology. Serology sensitivity was 66.67 %, specificity was 88.56 %, positive and negative predictive values were 36.36 % and 96.41 %, respectively, when using nested PCR as the diagnostic criteria.

Conclusions

In summary, our research established the critical role of M. pneumoniae infection in community-acquired LRTIs in children particularly in children under five years. There was an association between wheezing and acute M. pneumoniae infection. Multiplex PCR, nested PCR, and serology are used in conjunction to help diagnose M. pneumoniae infection in children with community-acquired LRTIs.

目的：在这项前瞻性研究中，采用血清学、巢式 PCR（聚合酶链反应）和多重 PCR 分析等方法调查了社区获得性下呼吸道感染（LRTI）患儿的肺炎双球菌感染率。在入院时和入院后四到六周抽取血样检测肺炎双球菌抗体。对鼻咽吸出物（NPA）进行巢式和多重 PCR 分析，以确定肺炎双球菌：结果：29名年龄小于5岁的儿童（74.35%）和10名年龄大于5岁的儿童（25.65%）感染了肺炎双球菌。肺炎链球菌与年龄的关系在 5 岁以下儿童中具有统计学意义[P=0.004]。男女儿童之间的差异无统计学意义[P=0.91]。临床和放射学结果与 M 型肺炎球菌感染无统计学意义上的显著相关性，但存在统计学意义上的浸润除外（P=0.04）。在 39 名（19.5%）儿童中，采用多重 PCR、巢式 PCR 和血清学相结合的方法发现了肺炎双球菌。以巢式 PCR 作为诊断标准时，血清学敏感性为 66.67%，特异性为 88.56%，阳性和阴性预测值分别为 36.36% 和 96.41%：总之，我们的研究确定了肺炎双球菌感染在社区获得性儿童 LRTI 中的关键作用，尤其是在五岁以下儿童中。喘息与急性肺炎双球菌感染有关。多重 PCR、巢式 PCR 和血清学可结合使用，帮助诊断社区获得性 LRTI 儿童的肺炎链球菌感染。

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引用次数: 0

Ralstonia pickettii bacteremia: A retrospective review of records 皮氏Ralstonia菌血症：记录的回顾性回顾。

IF 1.4 4区医学 Q4 IMMUNOLOGY

Indian Journal of Medical Microbiology

Pub Date : 2025-01-01 DOI: 10.1016/j.ijmmb.2024.100786

Anjely Sebastian , Nitin Gupta , Barnini Banerjee , K.E. Vandana , Chiranjay Mukhopadhyay , Tirlangi Praveen Kumar , Muralidhar Varma

Introduction

Ralstonia pickettii is a non-fermenting gram-negative bacillus rarely associated with hospital-acquired infections. The study aimed to characterise the clinical profile and outcomes of R. pickettii bacteremia cases.

Methodology

We retrospectively reviewed the hospital records to collect the details of the clinical profile and outcomes of patients with R. pickettii bacteremia between March and November 2021.

Results

Twenty-four patients were found to have Ralstonia pickettii bacteremia between March and May 2021. The cases were distributed across the hospital. All isolates were found to have similar antimicrobial susceptibility. The same organism with similar susceptibility was found to be in distilled water used to prepare in-house disinfectant and antiseptic agents. Commercial preparations replaced in-house solutions all over the hospital as a corrective measure. The distilled water tank was renovated, and repeat samples were found to be satisfactory. There were no further reports of Ralstonia pickettii between May and November 2021.

Conclusion

We report this to highlight the possibility of infection with this rare pathogen and to increase awareness of the importance of appropriate infection control measures.

简介：皮氏Ralstonia pickettii是一种非发酵革兰氏阴性杆菌很少与医院获得性感染相关。该研究的目的是表征的临床概况和结果的皮氏梭菌菌血症病例。方法：我们回顾性地回顾了医院记录，以收集2021年3月至11月期间pickettir菌血症患者的临床概况和结局的详细信息。结果：在2021年3月至5月期间，发现24例患者患有皮氏Ralstonia菌血症。这些病例分布在整个医院。所有分离株均具有相似的抗菌敏感性。在用于制备室内消毒剂和抗菌剂的蒸馏水中发现了具有相似敏感性的同一生物。作为一项纠正措施，商业制剂取代了整个医院的内部解决方案。对蒸馏水罐进行了翻新，重复取样合格。2021年5月至11月期间没有进一步的报道。结论：我们报告这一结果是为了强调这种罕见病原体感染的可能性，并提高人们对适当感染控制措施重要性的认识。

{"title":"Ralstonia pickettii bacteremia: A retrospective review of records","authors":"Anjely Sebastian , Nitin Gupta , Barnini Banerjee , K.E. Vandana , Chiranjay Mukhopadhyay , Tirlangi Praveen Kumar , Muralidhar Varma","doi":"10.1016/j.ijmmb.2024.100786","DOIUrl":"10.1016/j.ijmmb.2024.100786","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Ralstonia pickettii</em> is a non-fermenting gram-negative bacillus rarely associated with hospital-acquired infections. The study aimed to characterise the clinical profile and outcomes of <em>R. pickettii</em> bacteremia cases.</div></div><div><h3>Methodology</h3><div>We retrospectively reviewed the hospital records to collect the details of the clinical profile and outcomes of patients with <em>R. pickettii</em> bacteremia between March and November 2021.</div></div><div><h3>Results</h3><div>Twenty-four patients were found to have <em>Ralstonia pickettii</em> bacteremia between March and May 2021. The cases were distributed across the hospital. All isolates were found to have similar antimicrobial susceptibility. The same organism with similar susceptibility was found to be in distilled water used to prepare in-house disinfectant and antiseptic agents. Commercial preparations replaced in-house solutions all over the hospital as a corrective measure. The distilled water tank was renovated, and repeat samples were found to be satisfactory. There were no further reports of <em>Ralstonia pickettii</em> between May and November 2021.</div></div><div><h3>Conclusion</h3><div>We report this to highlight the possibility of infection with this rare pathogen and to increase awareness of the importance of appropriate infection control measures.</div></div>","PeriodicalId":13284,"journal":{"name":"Indian Journal of Medical Microbiology","volume":"53 ","pages":"Article 100786"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pattern of rapidly growing mycobacteria (RGM) species isolated from clinical samples: A 10-year retrospective study in a tertiary care hospital of Bangladesh 从临床样本中分离出的快速生长分枝杆菌（RGM）种类的模式：孟加拉国一家三级医院的 10 年回顾性研究。

IF 1.4 4区医学 Q4 IMMUNOLOGY

Indian Journal of Medical Microbiology

Pub Date : 2025-01-01 DOI: 10.1016/j.ijmmb.2024.100756

Lovely Barai , Mili Rani Saha , Tanjila Rahman , Marium Sukanya , Jannatul Ferdous , Adeeba Khanduker , Rokibul Hasan , TasfiaTasnim Nova

Purpose

Infections caused by rapidly growing mycobacteria (RGM) are increasing worldwide. The study was conducted in a microbiological laboratory of Bangladesh to determine the pattern of detection of RGM from clinical samples.

Methods

All laboratory culture records of RGM from 2012 to 2022 were collected retrospectively and analyzed.

Results

A total 62 RGM infected patients with surgical site infection (74.1 %), injection site and skin abscess (9.7 %), septicaemia (4.8 %) and UTI (1.6 %) were identified. The annual isolation frequency of RGM increased 4.8 %–29.1 % in between year 2012 and 2022. RGM infected patients (14.5 %) were mistakenly treated with first line anti tubercular drug before correct microbiological diagnosis (median, IQR; 3, 2–5 months). Out of 23 RGM isolates, 86.9 % were M. abscessus and rest 13.1 % were M. fortuitum. Most of them (≥95 %) were sensitive to amikacin, linezolid, clarithromycin where as 27.1 % to imipenem and ciprofloxacin, 40 % to cefoxitin, 35.3 % and 1.7 % to doxycycline and co-trimoxazole respectively.

Conclusion

Misdiagnosis or delay in diagnosis and erroneous treatment with first line anti tubercular drug may cause prolong morbidity and therapeutic failure to patients with RGM infection. So, early and appropriate diagnosis is crucial for successful outcome.

目的：快速生长分枝杆菌（RGM）引起的感染在全球范围内呈上升趋势。本研究在孟加拉国的一家微生物实验室进行，以确定从临床样本中检测 RGM 的模式：方法：回顾性收集并分析了 2012 年至 2022 年期间所有的 RGM 实验室培养记录：结果：共发现62名RGM感染者，他们分别患有手术部位感染（74.1%）、注射部位和皮肤脓肿（9.7%）、败血症（4.8%）和UTI（1.6%）。从 2012 年到 2022 年，RGM 的年分离频率增加了 4.8%，达到 29.1%。RGM感染者（14.5%）在得到正确的微生物学诊断前（中位数，IQR；3，2-5个月）被误用一线抗结核药物治疗。在 23 例 RGM 分离物中，86.9% 为脓肿霉菌，其余 13.1% 为 fortuitum 霉菌。其中大部分（≥95%）对阿米卡星、利奈唑胺、克拉霉素敏感，27.1%对亚胺培南和环丙沙星敏感，40%对头孢西丁敏感，35.3%和1.7%分别对多西环素和联合曲唑敏感：误诊或延误诊断以及错误地使用一线抗结核药物治疗可能会导致 RGM 感染患者发病时间延长和治疗失败。因此，早期和适当的诊断是成功治疗的关键。

{"title":"Pattern of rapidly growing mycobacteria (RGM) species isolated from clinical samples: A 10-year retrospective study in a tertiary care hospital of Bangladesh","authors":"Lovely Barai , Mili Rani Saha , Tanjila Rahman , Marium Sukanya , Jannatul Ferdous , Adeeba Khanduker , Rokibul Hasan , TasfiaTasnim Nova","doi":"10.1016/j.ijmmb.2024.100756","DOIUrl":"10.1016/j.ijmmb.2024.100756","url":null,"abstract":"<div><h3>Purpose</h3><div>Infections caused by rapidly growing mycobacteria (RGM) are increasing worldwide. The study was conducted in a microbiological laboratory of Bangladesh to determine the pattern of detection of RGM from clinical samples.</div></div><div><h3>Methods</h3><div>All laboratory culture records of RGM from 2012 to 2022 were collected retrospectively and analyzed.</div></div><div><h3>Results</h3><div>A total 62 RGM infected patients with surgical site infection (74.1 %), injection site and skin abscess (9.7 %), septicaemia (4.8 %) and UTI (1.6 %) were identified. The annual isolation frequency of RGM increased 4.8 %–29.1 % in between year 2012 and 2022. RGM infected patients (14.5 %) were mistakenly treated with first line anti tubercular drug before correct microbiological diagnosis (median, IQR; 3, 2–5 months). Out of 23 RGM isolates, 86.9 % were <em>M. abscessus</em> and rest 13.1 % were <em>M. fortuitum</em>. Most of them (≥95 %) were sensitive to amikacin, linezolid, clarithromycin where as 27.1 % to imipenem and ciprofloxacin, 40 % to cefoxitin, 35.3 % and 1.7 % to doxycycline and co-trimoxazole respectively.</div></div><div><h3>Conclusion</h3><div>Misdiagnosis or delay in diagnosis and erroneous treatment with first line anti tubercular drug may cause prolong morbidity and therapeutic failure to patients with RGM infection. So, early and appropriate diagnosis is crucial for successful outcome.</div></div>","PeriodicalId":13284,"journal":{"name":"Indian Journal of Medical Microbiology","volume":"53 ","pages":"Article 100756"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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