Indo Global Journal of Pharmaceutical Sciences最新文献

英文中文

Epilepsy: A Comprehensive Review 癫痫:全面回顾

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2019-01-01 DOI: 10.35652/igjps.2019.92s38

Suruchi Sharma, Vaishali Dixit

引用次数: 306

Polymer used in Novel Drug Delivery System 聚合物在新型给药系统中的应用

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2019-01-01 DOI: 10.35652/igjps.2019.92s25

Lovepreet, Pooja Sharma, Dinesh Kumar

Polymers play a major role in the development of drug delivery technology by release of two types of drugs like hydrophilic and hydrophobic. In a synchronized manner and constant release of formulations over extended periods. The general characteristic features that makes the polymer a potential candidate for drug delivery include, safety, efficacy, hydrophillicity, absence immunogenicity biological inactivity, sufficient pharmacokinetics, and presence of functional groups for covalent conjugation of drugs, targeting moieties or formation of copolymer. Polymers are the backbone of a pharmaceutical drug delivery system as they control the release of the drug from the device. The drug is release from polymer by diffusion, degradation and swelling. In addition to this review presents characteristics and behaviors of plant derived and mucoadhesive polymers which are currently used in drug delivery. © 2019 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Lovepreet; Sharma, P.; Kumar, D. Polymer used in Novel Drug Delivery System. Indo Global J. Pharm. Sci., 2019; 9(2Suppl.): 127. DOI: http://doi.org/10.35652/IGJPS.2019.92S25 . Indo Global Journal of Pharmaceutical Sciences( ISSN 2249 1023; CODENIGJPAI; NLM ID: 101610675) indexed and abstracted in CrossRef (DOI Enabling), UGC CARE Journal List, EMBASE(Elsevier), National Library of Medicine (NLM) Catalog, ResearchGate, Publons, CAS (ACS), Index Copernicus, Google Scholar and many more. For further details, visit http://iglobaljournal.com This is a special issue as an outcome of ‘RAPSCON-2019’ sponsored by APTI and organized by Sri Sai College of Pharmacy, Manawala, Amritsar, Punjab, India. Relaxation offered in journal format.

聚合物通过释放亲水性和疏水性两种类型的药物，在药物传递技术的发展中起着重要作用。以同步的方式和在较长时期内不断释放配方。使该聚合物成为药物递送的潜在候选者的一般特征包括:安全性、有效性、亲水性、无免疫原性、无生物活性、足够的药代动力学以及存在用于药物共价偶联、靶向部分或共聚物形成的官能团。聚合物是药物输送系统的支柱，因为它们控制药物从设备的释放。药物通过扩散、降解和溶胀从聚合物中释放出来。此外，本文还介绍了目前用于给药的植物源性和黏附性聚合物的特性和行为。©2019 igglobal研究与出版基金会。版权所有。引用这篇文章:Lovepreet;沙玛,p;高分子聚合物在新型给药系统中的应用。印度国际制药公司。科学。, 2019;9(2生理):127。DOI: http://doi.org/10.35652/IGJPS.2019.92S25。印度全球药物科学杂志(ISSN 2249 1023;CODENIGJPAI;NLM ID: 101610675)在CrossRef (DOI Enabling)， UGC CARE期刊列表，EMBASE(爱思唯尔)，国家医学图书馆(NLM)目录，ResearchGate, Publons, CAS (ACS)， Index Copernicus，谷歌Scholar等中索引和摘要。欲了解更多详情，请访问http://iglobaljournal.com这是由APTI赞助，印度旁遮普阿姆利则马纳瓦拉斯里赛药学院组织的“RAPSCON-2019”的特刊。以日志形式提供放松。

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引用次数: 1

Development of Molecular Condom by Using Anti-Fertility Phytochemical 抗生育植物化学分子避孕套的研制

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2019-01-01 DOI: 10.35652/igjps.2019.9202

A. B. Kadam, B. Gaykar

: There are some herbal contraceptives that have the property to avoid the embryo implantation. Trigonella foenum-graecum L. is used in folk medicine for prevention of pregnancy. Pregnane- progesterone is one of the important steroid found in Trigonella has direct connection with contraceptive activity.Pregnane is a C 21 steroid and indirectly, a parent of progesterone. The present study

有一些草药避孕药具有避免胚胎着床的特性。葫芦巴在民间医学中用于预防怀孕。孕酮-孕酮是Trigonella中发现的重要甾体之一，与避孕活性有直接关系。孕酮是一种c21类固醇，间接地是孕酮的母体。目前的研究

引用次数: 0

A Review on the Urease Inhibition Potential of Various Compounds 各种化合物脲酶抑制潜力的研究进展

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2019-01-01 DOI: 10.35652/igjps.2019.9106

Parvinder, S. Kakkar, A. Khatkar

引用次数: 1

Mechanism and Effects of Pre-Exposure Prophylaxis (PrEP) Drugs Used for Prevention of HIV 暴露前预防(PrEP)药物预防HIV的作用机制及效果

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2019-01-01 DOI: 10.35652/igjps.2019.92s04

Kampala Mwape Phiri, S. Patyar

引用次数: 0

Antibiotic Resistance Pattern in Developing Countries 发展中国家的抗生素耐药性模式

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2019-01-01 DOI: 10.35652/igjps.2019.92s21

A. Isa, Yusuf A. Isa, I. Muhammad, H. B. Goni

Medicines used for prevention and treatment of infection particularly bacterial infections are referred to as an antibiotic. Antibiotic is administered after surgery to kill potential infectious agents, while it is been prescribe after the manifestation of clinical sign and symptoms as well as laboratory diagnosis. Antibiotic is administered to inactivate bacteria responsible for food poisoning, wounds sepsis, respiratory tract infection, sexually transmitted infection, gastrointestinal tract infection, urinary tract infection etc. However, under certain condition bacteria developed a mechanism(s) that inactivate the bacteriostatic or bactericidal effects of the antibiotic and hence antibiotic resistance occurred. Consequently, prolong hospitalization and treatment, increase medical bill and mortality become widespread. Health care awareness, personal hygiene, agricultural products, food and industrial practices, the proliferation of substandard drugs, self-medication are some of the causes of antibiotic resistance in developing countries. © 2019 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Isa, A.; Isa, Y.A.; Muhammad, I.; Goni, H.B. Antibiotic Resistance Pattern in Developing Countries. Indo Global J. Pharm. Sci., 2019; 9(2Suppl.): 123. DOI: http://doi.org/10.35652/IGJPS.2019.92S21 . Indo Global Journal of Pharmaceutical Sciences( ISSN 2249 1023; CODENIGJPAI; NLM ID: 101610675) indexed and abstracted in CrossRef (DOI Enabling), UGC CARE Journal List, EMBASE(Elsevier), National Library of Medicine (NLM) Catalog, ResearchGate, Publons, CAS (ACS), Index Copernicus, Google Scholar and many more. For further details, visit http://iglobaljournal.com This is a special issue as an outcome of ‘RAPSCON-2019’ sponsored by APTI and organized by Sri Sai College of Pharmacy, Manawala, Amritsar, Punjab, India. Relaxation offered in journal format.

用于预防和治疗感染，特别是细菌感染的药物被称为抗生素。抗生素在手术后施用，以杀死潜在的感染因子，而在出现临床体征和症状以及实验室诊断后才开处方。抗生素用于灭活引起食物中毒、伤口败血症、呼吸道感染、性传播感染、胃肠道感染、尿路感染等的细菌。然而，在一定条件下，细菌发展出一种机制，使抗生素的抑菌或杀菌作用失活，从而产生抗生素耐药性。因此，延长住院和治疗时间，增加医疗费用和死亡率变得普遍。保健意识、个人卫生、农产品、食品和工业做法、不合格药物的扩散、自我药疗是发展中国家抗生素耐药性的一些原因。©2019 igglobal研究与出版基金会。版权所有。引用本文如下:Isa, A.;Isa Y.A.;默罕默德,即;发展中国家的抗生素耐药模式。印度国际制药公司。科学。, 2019;9(2生理):123。DOI: http://doi.org/10.35652/IGJPS.2019.92S21。印度全球药物科学杂志(ISSN 2249 1023;CODENIGJPAI;NLM ID: 101610675)在CrossRef (DOI Enabling)， UGC CARE期刊列表，EMBASE(爱思唯尔)，国家医学图书馆(NLM)目录，ResearchGate, Publons, CAS (ACS)， Index Copernicus，谷歌Scholar等中索引和摘要。欲了解更多详情，请访问http://iglobaljournal.com这是由APTI赞助，印度旁遮普阿姆利则马纳瓦拉斯里赛药学院组织的“RAPSCON-2019”的特刊。以日志形式提供放松。

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引用次数: 0

Nanoparticles Characterization and Applications: An Overview 纳米颗粒的表征和应用:综述

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2019-01-01 DOI: 10.35652/igjps.2019.92s44

S. Kaur, Parampal Kaur

引用次数: 5

O-Pentyne and Morpholine/Piperidine Ethyl Substituted Pyrimidines as Anti-Alzheimer’s Agents 邻戊炔和吗啡啉/哌啶乙基取代嘧啶作为抗阿尔茨海默病药物

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2019-01-01 DOI: 10.35652/igjps.2019.92s14

Devashish Mehta, Vijay L Kumar, Vinod Kumar

Alzheimer’s disease (AD) is an irreversible neurodegenerative disorder. It is characterized by the impairment in memory and cognitive dysfunctioning. The neuropathological hallmarks of AD are decreased acetylcholine (Ach) levels in brain, increased reactive oxygen species (ROS) and deposition of amyloid beta. The exact pathogenesis of AD is still not clear. In AD there is hyperactivity of acetylcholinesterase (AchE) and monoamine oxidase –B (MAO-B), which leads to decreased Ach and increased ROS levels respectively. So, AchE and MAO-B are the potential therapeutic targets for the treatment of AD. Simultaneous inhibition of these target enzymes with a single molecule can be a beneficial therapeutic strategy. A total of 9 multi-targeted compounds are designed and synthesized using hybrid molecular approach and two pharmacophores are incorporated on the pyrimidine nucleus. The in-silico studies of these compounds revealed that the compound DEV-28possess potent AchE and MAO-B inhibitory properties. © 2019 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Mehta, D.; Kumar, V.; Kumar, V. O-Pentyne and morpholine/piperidine ethyl substituted pyrimidines as anti-alzheimer’s agents. Indo Global J. Pharm. Sci., 2019; 9(2Suppl.): 116. DOI: http://doi.org/10.35652/IGJPS.2019.92S14 . Indo Global Journal of Pharmaceutical Sciences( ISSN 2249 1023; CODENIGJPAI; NLM ID: 101610675) indexed and abstracted in CrossRef (DOI Enabling), UGC CARE Journal List, EMBASE(Elsevier), National Library of Medicine (NLM) Catalog, ResearchGate, Publons, CAS (ACS), Index Copernicus, Google Scholar and many more. For further details, visit http://iglobaljournal.com This is a special issue as an outcome of ‘RAPSCON-2019’ sponsored by APTI and organized by Sri Sai College of Pharmacy, Manawala, Amritsar, Punjab, India. Relaxation offered in journal format.

阿尔茨海默病(AD)是一种不可逆的神经退行性疾病。它的特点是记忆损伤和认知功能障碍。阿尔茨海默病的神经病理学特征是脑内乙酰胆碱(Ach)水平降低、活性氧(ROS)增加和β淀粉样蛋白沉积。阿尔茨海默病的确切发病机制尚不清楚。同时用单分子抑制这些靶酶可能是一种有益的治疗策略。采用杂化分子方法设计合成了9个多靶点化合物，并在嘧啶核上结合了两个药效团。©2019 igglobal研究与出版基金会。版权所有。引用本文如下:Mehta, D.;Kumar诉;o -戊炔和吗啡啉/哌啶乙基取代嘧啶作为抗阿尔茨海默病药物。印度国际制药公司。科学。, 2019;9(2生理):116。DOI: http://doi.org/10.35652/IGJPS.2019.92S14。印度全球药物科学杂志(ISSN 2249 1023;CODENIGJPAI;NLM ID: 101610675)在CrossRef (DOI Enabling)， UGC CARE Journal List, EMBASE(Elsevier)， National Library of Medicine (NLM) Catalog, ResearchGate, Publons, CAS (ACS)， Index哥白尼，Google Scholar等中索引和摘要。欲了解更多详情，请访问http://iglobaljournal.com这是由APTI赞助，印度旁遮普阿姆利则马纳瓦拉斯里赛药学院组织的“RAPSCON-2019”的特刊。以日志形式提供放松。

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引用次数: 0

Integrated Management of Linseed Blight by Green Silver Nanoparticles Synthesized from Fruit and Leaves Extract of Morinda citrifolia L. 桑椹叶提取物合成纳米绿银对亚麻白叶病的综合治理。

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2019-01-01 DOI: 10.35652/igjps.2019.9204

Shital B. Koparde, D. Gaikwad

In the present work, an attempt has been made to synthesize green silver nanoparticles by using medicinal plant Morinda citrifolia. Biologically synthesized nanoparticles have been used widely in the various fields. Morinda fruit and leaves extract was used to reduce silver nitrate to synthesized silver nanoparticles. The peak showed at 425nm for fruits and 425 to 450nm for leaves sample by Uv-vis spectrophotometer and FESEM analysis reveales the spherical shaped nanoparticles with size ranging between 25-60 nm and 40-60nm respectively. These synthesized nanoparticles showed inhibitory activity against Alternaria lini a linseed blight pathogen. The 3% carbendazim showed inhibition of growth of fungi A.lini, Whereas Carbendazim combined with silver nanoparticles significantly inhibit the growth of A.lini. This will help to reduce the percentage of carbendazim and also help to minimize the fungicide residues. Thus these nanoparticles synthesized from M. citrifolia fruits and leaves might be used in agricultural industries for the development of efficient fungicide. This will helps to reduce the amount of fungicide and residual biomagnifications in food chain. © 2019 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Koparde, S.B.; Gaikwad, D.K. Integrated management of linseed blight by green silver nanoparticles synthesized from fruit and leaves extract of Morinda citrifolia L. Indo Global J. Pharm. Sci., 2019; 9(2): 73-76. DOI: http://doi.org/10.35652/IGJPS.2019.9204 . Indo Global Journal of Pharmaceutical Sciences, 2019; 9(2): 73-76 74 minutes. The extract was cooled and filtered using whatman no. 1 filter paper and used for the further reaction. Silver nanoparticles synthesis For the synthesis of silver nanoparticles M. citrifolia fruit and leaves extract was reacted with silver nitrate solution. 10 ml extract added to the 90 ml silver nitrate solution. This reaction mixture containing conical flask was kept in dark condition at room temperature. The bioreduction of silver ions by fruit and leaves extract was scrutinized by measuring the Uv-vis spectra of the reaction medium at 200-800nm. Complete bioreduced sample was centrifuged at 10000 rpm for 15 minutes, redispersed the pellet in double distilled water and again centrifuged. This process was repeated for 2-3 times for obtaining silver nanoparticles free from any unwanted residue [8 and 13].

本研究以药用植物桑叶为原料，尝试合成绿色纳米银。生物合成纳米粒子已广泛应用于各个领域。以巴戟达果叶提取物还原硝酸银合成纳米银。通过紫外-可见分光光度计和FESEM分析，果实样品和叶片样品的峰值分别出现在425 ~ 450nm处和425 ~ 450nm处，结果表明纳米颗粒呈球形，尺寸分别在25 ~ 60nm和40 ~ 60nm之间。合成的纳米颗粒对亚麻籽疫病病菌linalternaria lini具有抑制作用。3%多菌灵对真菌的生长有抑制作用，而多菌灵与纳米银粒子联用对真菌的生长有明显的抑制作用。这将有助于减少多菌灵的百分比，也有助于减少杀菌剂残留。因此，这些以枸杞果实和叶片为原料合成的纳米颗粒可用于农业工业中高效杀菌剂的开发。这将有助于减少杀菌剂和食物链中残留的生物放大物的数量。©2019 igglobal研究与出版基金会。版权所有。引用本文如下:Koparde, S.B.;陈晓明，王晓明。桑葚果实和叶提取物合成纳米绿银的研究进展[j]。科学。, 2019;9(2): 73 - 76。DOI: http://doi.org/10.35652/IGJPS.2019.9204。印度全球制药科学杂志，2019;9(2): 73-76 74分钟。提取液用whatmanno冷却过滤。1张滤纸，用于进一步反应。纳米银的合成以硝酸银溶液为原料，制备了纳米银。将10毫升提取物加入90毫升硝酸银溶液中。在室温下，将含有锥形烧瓶的反应混合物置于黑暗条件下保存。通过测定反应介质在200-800nm处的紫外可见光谱，考察了果实和叶片提取物对银离子的生物还原作用。完整的生物还原样品在10000 rpm下离心15分钟，将颗粒重新分散在双蒸馏水中，再次离心。这个过程重复2-3次，以获得没有任何不需要的残留物的银纳米颗粒[8和13]。

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引用次数: 2

Influence of Various Culture Media on Growth and Carbohydrates Content in a Cyanobacterium Nostoc muscorum 不同培养基对褐藻生长和碳水化合物含量的影响

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2019-01-01 DOI: 10.35652/igjps.2019.9201

C. S. Arsule, B. Sonawane

Method of collection: The soil samples from 5-10 cm deep soil layers were collected using the scalpels. Soil samples were collected in polythene bags of size 6 x 4 inches. ABSTRACT: Nostoc muscorum was isolated from the collected soil samples from different locations. Identification was carried out using morphological variation and taxonomical approaches according to Desikachary (1959). The axenic culture of Nostoc muscorum was obtained in the laboratory. For the biomass production, different culture media were used namely BG-11, Fogg’s medium, Allen and Arnon medium, Zarrouk’s medium and CFTRI medium. The biomass was harvested by filtration through double layered muslin cloth and dried using air blower. After harvesting, the biomass obtained was subjected to the growth analysis. The total carbohydrates were estimated by following Anthrone method (Hedge and Hofreiter, 1962). Out of the different culture media used, BG-11 medium supported the growth of Nostoc muscorum properly as compared to other media used. The total carbohydrates content was more in Nostoc muscorum grown in CFTRI medium followed by the Allen and Arnon medium. © 2019 iGlobal Research and Publishing Foundation. All

采集方法:采用手术刀采集5 ~ 10 cm土层土壤样品。土壤样本收集在6 × 4英寸大小的聚乙烯袋中。摘要:从不同地点采集的土壤样品中分离到念珠菌。采用Desikachary(1959)的形态学变异和分类学方法进行鉴定。在实验室中获得了诺斯托克菌的无菌培养。生物量生产采用BG-11培养基、Fogg培养基、Allen and Arnon培养基、Zarrouk培养基和CFTRI培养基。采用双层平纹棉布过滤收获生物质，风机干燥。收获后，获得的生物量进行生长分析。碳水化合物总量采用Anthrone法估算(Hedge and Hofreiter, 1962)。在使用的不同培养基中，BG-11培养基比其他培养基更能支持Nostoc的生长。总碳水化合物含量在CFTRI培养基中最高，Allen和Arnon培养基次之。©2019 igglobal研究与出版基金会。所有

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引用次数: 0

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