Pub Date : 2019-01-01DOI: 10.35652/IGJPS.2019.9104
Swathi Putta, Lingaswamy Bantu, N. Yarla, R. Undi
{"title":"Morus alba Improves Hyperglycemia, Hyperlipidemia and Oxidative Stress in Streptozotocin-Induced Diabetic Nephropathy","authors":"Swathi Putta, Lingaswamy Bantu, N. Yarla, R. Undi","doi":"10.35652/IGJPS.2019.9104","DOIUrl":"https://doi.org/10.35652/IGJPS.2019.9104","url":null,"abstract":"","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75325121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.35652/igjps.2019.92s53
Mandeep Kaur heir, Sachin Sharma
utilize the skin for the delivery of drug molecules from the surface of the skin, through its layers, to the circulatory system. Transdermal Systems are a noninvasive alternative to drug delivery through injection or by mouth. TDD systems exist as passive or active systems. The passive system uses a simple concentration gradient to diffuse the blood through the skin to the bloodstream. The Transdermal patches on the market (such as the nicotine patch), are passive systems. The molecules administered through these patches are small. The Stratum-Corneum (outermost layer of skin) has low permeability to larger molecules. The active systems employ a physical mechanism to force the larger molecules across the skin. One such mechanism is the ultrasound. Lowfrequency (20 kHz) ultrasound can increase the permeability of human skin to high-molecular-weight -drugs. Ultrasound causes cavitation, or growth and oscillation of the air pockets in the skin's keratin fibers. The stratum corneum (outer skin layer) consists of cells called Keratinocites surrounded by lipid bilayers. Low frequency ultrasound generates microbubbles in the tissue. Researchers suggest the bubbles disrupt the lipid bilayer and allow water channels to be produced within the bilayer. The disorder in the stratum corneum facilitates the crossing of a larger molecule. This process is of particular significance to the delivery of insulin to diabetics. Insulin protein is too large to permeate the skin without use of the active transdermal system. A team of researchers completed an Insulin patch prototype in October of last year. This device provides needle free delivery of insulin via a wearable patch. It has been tested to safely administer effective dosages of insulin in rats. Down the road researchers hope to devise a patch delivery system that will detect glucose and administer insulin. Transdermal Drug Delivery System (Ultrasound Transdermal Delivery System and the Insulin Patch)
{"title":"Transdermal Drug Delivery System","authors":"Mandeep Kaur heir, Sachin Sharma","doi":"10.35652/igjps.2019.92s53","DOIUrl":"https://doi.org/10.35652/igjps.2019.92s53","url":null,"abstract":"utilize the skin for the delivery of drug molecules from the surface of the skin, through its layers, to the circulatory system. Transdermal Systems are a noninvasive alternative to drug delivery through injection or by mouth. TDD systems exist as passive or active systems. The passive system uses a simple concentration gradient to diffuse the blood through the skin to the bloodstream. The Transdermal patches on the market (such as the nicotine patch), are passive systems. The molecules administered through these patches are small. The Stratum-Corneum (outermost layer of skin) has low permeability to larger molecules. The active systems employ a physical mechanism to force the larger molecules across the skin. One such mechanism is the ultrasound. Lowfrequency (20 kHz) ultrasound can increase the permeability of human skin to high-molecular-weight -drugs. Ultrasound causes cavitation, or growth and oscillation of the air pockets in the skin's keratin fibers. The stratum corneum (outer skin layer) consists of cells called Keratinocites surrounded by lipid bilayers. Low frequency ultrasound generates microbubbles in the tissue. Researchers suggest the bubbles disrupt the lipid bilayer and allow water channels to be produced within the bilayer. The disorder in the stratum corneum facilitates the crossing of a larger molecule. This process is of particular significance to the delivery of insulin to diabetics. Insulin protein is too large to permeate the skin without use of the active transdermal system. A team of researchers completed an Insulin patch prototype in October of last year. This device provides needle free delivery of insulin via a wearable patch. It has been tested to safely administer effective dosages of insulin in rats. Down the road researchers hope to devise a patch delivery system that will detect glucose and administer insulin. Transdermal Drug Delivery System (Ultrasound Transdermal Delivery System and the Insulin Patch)","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78694426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.35652/igjps.2019.92s51
I. Sharma, Kuldeep Singh
Alzheimer's disease (AD) is an age-related, non-reversible neurodegenerative disease. AD is characterized by cognitive and behavioral problems. It is the most common cause of dementia among people aged 65yrs and older. It is the third leading cause of death in developed countries Alzheimer disease accounts for 60-70% cases of progressive cognitive impairment in elderly patients. The disease is more common among women than men by a ratio of 1.2 to 1.5. Two basic types of AD are familial and sporadic. While familial AD (FAD) is a rare form of AD, affecting less than 10 percent of AD patients, sporadic AD comprises the remaining 85-90%. However, no effective therapy exists till date. Because of the increased safety concerns about the synthetic drugs, cheaper and safer sources of drugs based on natural origin are the focus of current research. The traditional medicine all over the world is nowadays revalued by an extensive research activity on different plant species and their therapeutic applications. Since they have a relatively higher therapeutic index, lesser side effects and are economical, herbal drugs have gained a lot of acceptance and popularity in the recent years. These plants may show beneficial effects in animal models of AD. Pooja Arora* 1 , Harjeet Singh 2 1. Department of Pharmacology, H.R. Institute of Pharmacy, 7th km stone, Delhi-Meerut Road, Morta, Ghaziabad, U.P.-201003 2. Department of Pharmaceutics, H.R Institute of Pharmacy, 7th km stone, Delhi-Meerut Road, Morta, Ghaziabad, U.P.-201003 Submission: 19 August 2017 Accepted: 27 August 2017 Published: 30 September 2017 www.ijppr.humanjournals.com Citation: Pooja Arora et al. Ijppr.Human, 2017; Vol. 10 (2):218-230. 219 INTRODUCTION Alzheimer's disease (AD) is an age-related, non-reversible neurodegenerative disease. AD is characterized by cognitive and behavioral problems. It is the most common cause of dementia among people aged 65yrs and older. It is the third leading cause of death in developed countries (Ewbank, 1991). Alzheimer disease accounts for 60-70% cases of progressive cognitive impairment in an elderly patients. The total prevalence of AD in the United States is estimated at 2.3 million (range, 1.09 4.8 million) (Brookmeyer et al, 1998). The prevalence of AD doubles every 5 years after the age of 60yrs, increasing from a prevalence of 1% among those 60-64 years-old to up to 40% of those aged 85 years and older (Von Strauss et al, 1999). The disease is more common among women than men by a ratio of 1.2 to 1.5 (Gao et al, 1998). Two basic types of AD are familial and sporadic. While familial AD (FAD) is a rare form of AD, affecting less than 10 percent of AD patients, sporadic AD comprises the remaining 85-90 %. FAD is frequently observed in younger people while sporadic AD is related to advancing age and ultimately affects almost half of the population over the age 85 (Yaffe, 1998). It leads to death within an average of 8 years after diagnosis, the last 3 of which are
{"title":"Alzheimer’s Disease: A Review","authors":"I. Sharma, Kuldeep Singh","doi":"10.35652/igjps.2019.92s51","DOIUrl":"https://doi.org/10.35652/igjps.2019.92s51","url":null,"abstract":"Alzheimer's disease (AD) is an age-related, non-reversible neurodegenerative disease. AD is characterized by cognitive and behavioral problems. It is the most common cause of dementia among people aged 65yrs and older. It is the third leading cause of death in developed countries Alzheimer disease accounts for 60-70% cases of progressive cognitive impairment in elderly patients. The disease is more common among women than men by a ratio of 1.2 to 1.5. Two basic types of AD are familial and sporadic. While familial AD (FAD) is a rare form of AD, affecting less than 10 percent of AD patients, sporadic AD comprises the remaining 85-90%. However, no effective therapy exists till date. Because of the increased safety concerns about the synthetic drugs, cheaper and safer sources of drugs based on natural origin are the focus of current research. The traditional medicine all over the world is nowadays revalued by an extensive research activity on different plant species and their therapeutic applications. Since they have a relatively higher therapeutic index, lesser side effects and are economical, herbal drugs have gained a lot of acceptance and popularity in the recent years. These plants may show beneficial effects in animal models of AD. Pooja Arora* 1 , Harjeet Singh 2 1. Department of Pharmacology, H.R. Institute of Pharmacy, 7th km stone, Delhi-Meerut Road, Morta, Ghaziabad, U.P.-201003 2. Department of Pharmaceutics, H.R Institute of Pharmacy, 7th km stone, Delhi-Meerut Road, Morta, Ghaziabad, U.P.-201003 Submission: 19 August 2017 Accepted: 27 August 2017 Published: 30 September 2017 www.ijppr.humanjournals.com Citation: Pooja Arora et al. Ijppr.Human, 2017; Vol. 10 (2):218-230. 219 INTRODUCTION Alzheimer's disease (AD) is an age-related, non-reversible neurodegenerative disease. AD is characterized by cognitive and behavioral problems. It is the most common cause of dementia among people aged 65yrs and older. It is the third leading cause of death in developed countries (Ewbank, 1991). Alzheimer disease accounts for 60-70% cases of progressive cognitive impairment in an elderly patients. The total prevalence of AD in the United States is estimated at 2.3 million (range, 1.09 4.8 million) (Brookmeyer et al, 1998). The prevalence of AD doubles every 5 years after the age of 60yrs, increasing from a prevalence of 1% among those 60-64 years-old to up to 40% of those aged 85 years and older (Von Strauss et al, 1999). The disease is more common among women than men by a ratio of 1.2 to 1.5 (Gao et al, 1998). Two basic types of AD are familial and sporadic. While familial AD (FAD) is a rare form of AD, affecting less than 10 percent of AD patients, sporadic AD comprises the remaining 85-90 %. FAD is frequently observed in younger people while sporadic AD is related to advancing age and ultimately affects almost half of the population over the age 85 (Yaffe, 1998). It leads to death within an average of 8 years after diagnosis, the last 3 of which are","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"77 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91371850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.35652/igjps.2019.92s28
Ajeet Singh
{"title":"Pharmacological Actions of Impatiens","authors":"Ajeet Singh","doi":"10.35652/igjps.2019.92s28","DOIUrl":"https://doi.org/10.35652/igjps.2019.92s28","url":null,"abstract":"","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"os-8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87655981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.35652/igjps.2019.92s17
Pawanpreet Kaur, R. Sodhi, Anjoo Kamboj, A. Babu
{"title":"Ebola: Treatment by Herbal Remedies","authors":"Pawanpreet Kaur, R. Sodhi, Anjoo Kamboj, A. Babu","doi":"10.35652/igjps.2019.92s17","DOIUrl":"https://doi.org/10.35652/igjps.2019.92s17","url":null,"abstract":"","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"126 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78557892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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