Indo Global Journal of Pharmaceutical Sciences最新文献_第7页

UV-Spectrophotometric Estimation and Forced Degradation Studies of Tenofovir Alafenamide Fumarate (TAF) in its Bulk and Tablet Dosage Form 富马酸替诺福韦阿拉那胺(TAF)原料药和片剂的紫外分光光度测定及强制降解研究

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2020-03-01 DOI: 10.5958/0974-360x.2020.00227.9

K. Bhavyasri, M. Manisha

A simple, sensitive and reproducible Spectrophotometric method is developed for estimation of Tenofovir Alafenamide Fumarate (TAF) in bulk and its tablet dosage form. Forced degradation studies are also conducted on standard TAF and % degradation of drug under various stress conditions is reported. Different concentrations of TAF are prepared using distilled water: acetonitrile as diluent. The absorption maximum of TAF is found to be at 261nm. Linearity was established in the range of 6.25-37.5 μg/ml with regression coefficient of 0.999. The drug was subjected to acid and alkali hydrolysis, oxidation degradation, thermal and photo degradation conditions. © 2020 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Bhavyasri, K.; Manisha, M.; Rambabu, D. UV-spectrophotometric estimation and forced degradation studies of tenofovir alafenamide fumarate (TAF) in its bulk and tablet dosage form. Indo Global J. Pharm. Sci., 2020; 10(4): 1-5. DOI: http://doi.org/10.35652/IGJPS.2020.10401 . Indo Global Journal of Pharmaceutical Sciences, 2020; 10(4): 1-5 2 Simultaneous estimation of TAF and Emtricitabine by UV spectroscopic method is found in a literature. The method involving determination of TAF and Emtricitabine at 260nm and 280nm over the concentration ranges of 5-30μg/ml for both drugs has been described [6]. Most of the reported methods are often time consuming, expensive, use multi or expensive reagents, cumbersome and required expertise operational personnel. UV spectrophotometry, because of simplicity, reproducibility and speed and also it requires minimum solvent/reagent system and less analysis time, is widely used for the assay of the therapeutic compounds used as medications. MATERIALS AND METHODS Apparatus The Spectrophotometric measurements were carried out using Elico SL 210 UV/Visible spectrophotometer.

建立了一种简便、灵敏、重复性好的富马酸替诺福韦阿拉那胺(TAF)原料药和片剂含量测定方法。对标准TAF进行了强制降解研究，并报道了不同应力条件下药物的降解率。以蒸馏水乙腈为稀释剂制备不同浓度的TAF。TAF的最大吸收波长为261nm。在6.25 ~ 37.5 μg/ml范围内呈线性关系，回归系数为0.999。药物经过酸、碱水解、氧化降解、热降解和光降解等条件。©2020全球研究与出版基金会。版权所有。引用本文如下:Bhavyasri, K.;Manisha m;紫外分光光度法测定富马酸替诺福韦(TAF)原料药和片剂的强制降解研究。印度国际制药公司。科学。, 2020;10(4): 1 - 5。DOI: http://doi.org/10.35652/IGJPS.2020.10401。印度全球药物科学杂志，2020;10(4): 1-5有文献报道紫外光谱法同时测定TAF和恩曲他滨。已有文献报道了两种药物在260nm和280nm，浓度范围为5-30μg/ml下测定TAF和恩曲他滨的方法[6]。多数报道的方法往往耗时长、价格昂贵，使用多种或昂贵的试剂，操作繁琐且需要专业操作人员。紫外分光光度法具有简便、快速、重现性好、所需溶剂/试剂系统少、分析时间短等优点，被广泛应用于药物治疗性化合物的分析。采用Elico SL 210紫外/可见分光光度计进行分光光度测定。

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引用次数: 1

A Stability Indicating Method Development of Atorvastatin Calcium and Amlodipine Besylate in Combined Tablet Dosage Forms by RPHPLC 阿托伐他汀钙与苯磺酸氨氯地平复合片剂稳定性指示方法的RPHPLC建立

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2020-01-01 DOI: 10.35652/igjps.2020.10111

A. Indira, N. Sreedhar

A new stability indicating RP-HPLC method was developed for simultaneous estimation of atorvastatin and amlodipine in combined tablet formulations. Chromatography was carried out on a Kromasil C18 HPLC Column (250 x 4.6 mm; 5μm) eluting with a mobile phase consisting of a 60:40 v/v mixture of 0.1% orthophosphoric acid in water and acetonitrile (ACN) at a flow rate of 1.0 mL/ minute. The detection wavelength was set at 240 nm. Accuracy was assessed by using standard addition method. The developed HPLC method was validated with respect to precision, specificity, accuracy, linearity and robustness. Forced degradation studies on the formulation were conducted by adopting the proposed method to assess the stability of the analytes under acid, base, peroxide, thermal and photolytic conditions and suitability of the method to resolve the degradation products. © 2020 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Indira, A.; Sreedhar, N.Y. A stability indicating method development of atorvastatin calcium and amlodipine besylate in combined tablet dosage forms by RP-HPLC. Indo Global J. Pharm. Sci., 2020; 10(1): 79-84. DOI: http://doi.org/10.35652/IGJPS.2020.10111 . Indo Global Journal of Pharmaceutical Sciences, 2020; 10(1): 79-84 80 atorvastatin and amlodipine in bulk and pharmaceutical dosage forms. Fig. 1: Structure of a) Atorvastatin b) Amlodipine MATERIALS AND METHODS Chemicals and Reagents Amlodipine besylate and Atorvastatin calcium were obtained as gift samples from Mylan Laboratories Ltd., Hyderabad. Methanol AR grade, HCl, NaOH and hydrogen peroxide were procured from SD Fine Chem limited, Mumbai. HPLC water and Methanol were purchased from Merck specialties private limited, Mumbai. The combination tablets AMTR 10 were purchased from local pharmacy.

建立了同时测定复方阿托伐他汀和氨氯地平含量的反相高效液相色谱法。色谱柱为Kromasil C18 (250 × 4.6 mm;5μm)，流动相为0.1%正磷酸水溶液与乙腈(ACN)的比例为60:40 v/v，流速为1.0 mL/ min。检测波长为240 nm。采用标准加法法评价准确度。该方法精密度、特异度、准确度、线性度和鲁棒性均得到验证。采用该方法对该制剂进行强制降解研究，评估分析物在酸、碱、过氧化物、热和光解条件下的稳定性，以及该方法对降解产物的适宜性。©2020全球研究与出版基金会。版权所有。引用本文如下:英迪拉，A.;用反相高效液相色谱法测定阿托伐他汀钙和苯磺酸氨氯地平复方片剂的稳定性。印度国际制药公司。科学。, 2020;10(1): 79 - 84。DOI: http://doi.org/10.35652/IGJPS.2020.10111。印度全球药物科学杂志，2020;[10](1): 79-84]阿托伐他汀和氨氯地平的散装和药用剂型。图1:a)阿托伐他汀b)氨氯地平的结构材料与方法化学与试剂苯磺酸氨氯地平和阿托伐他汀钙作为礼品样品从Hyderabad Mylan Laboratories Ltd.获得。甲醇AR级、HCl、NaOH和过氧化氢采购自孟买SD精细化学有限公司。HPLC水和甲醇购自孟买默克专业私人有限公司。该联合片剂amtr10是从本地药房购买。

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引用次数: 1

Molecular Docking Studies of Deva Chooranam against the Target Protein 6LU7 of Novel Corona Virus 2019 Deva Chooranam抗新型冠状病毒靶蛋白6LU7的分子对接研究

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2020-01-01 DOI: 10.35652/IGJPS.2020.10204

K. Thangadurai, Rengasundari, P SaravanaSiva, N Vithyavani, K. Sivasankari, R. Ramya, R JeevaGladys, K. Kannan

Plants and bioactive compounds have played an important role in the development of several clinically useful therapeutic agents since time immemorial. In the recent years, more emphasis has been placed on identifying plant-derived compounds that can be used as an effective treatment for life-threatening diseases. COVID-19, a new strain of coronavirus (CoV), was identified in Wuhan, China, in 2019. No specific therapies are available and investigations regarding COVID-19 treatment are lacking. Bioactive compounds found in Siddha herbal formulation Deva Chooranam which was previously confirmed through molecular docking to have antiviral effects against HIV -RT. The present study aimed to assess Deva Chooranam as potential COVID-19 Mpro inhibitor. Molecular docking was performed using Autodock 4.2, with the Lamarckian Genetic Algorithm and results were visualized using pymol. The physiochemical and ADMET(Adsorption, distribution, metabolism and excretion) properties were also analysed.COVID-19 Mpro was docked with several compounds, Eugenol A-Pinene, Atlantone, Myrcene, Luteolin, Apigenin, Kaempferol and docking was analysed using Pymol. The results showed that out of the 7 compounds screened Luteolin appeared to have the best potential binding against the COVID-19 Mpro 6LU7. However, further research is necessary to investigate their potential medicinal use. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.

自古以来，植物和生物活性化合物在一些临床有用的治疗剂的开发中发挥了重要作用。近年来，人们越来越重视鉴定植物源性化合物，以有效治疗危及生命的疾病。2019年，在中国武汉发现了一种新型冠状病毒COVID-19。没有特定的治疗方法，也缺乏关于COVID-19治疗的调查。在Siddha草药制剂Deva Chooranam中发现的生物活性化合物，先前通过分子对接证实对HIV -RT具有抗病毒作用。本研究旨在评估Deva Chooranam作为潜在的COVID-19 Mpro抑制剂。使用Autodock 4.2进行分子对接，使用lamarkian遗传算法，并使用pymol将结果可视化。分析了其理化性质和ADMET(吸附、分布、代谢和排泄)特性。COVID-19 Mpro与丁香酚a -蒎烯、亚特兰大酮、月桂烯、木犀草素、芹菜素、山奈酚等化合物对接，并使用Pymol分析对接情况。结果表明，在筛选的7个化合物中，木犀草素对COVID-19 Mpro 6LU7的结合潜力最好。然而，有必要进一步研究其潜在的药用价值。©2020全球研究与出版基金会。版权所有。

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引用次数: 1

Preparation And Evaluation Of Directly Compressible Tablets Of Ketoprofen Crystals 酮洛芬晶体直接可压片的制备及评价

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2020-01-01 DOI: 10.35652/igjps.2020.10303

Pooja D. Vaghela, H. M. Tank

Purpose: The aim of present investigation was to prepare the directly compressible tablets of Ketoprofen loaded crystals and the prepared tablets were evaluated for the improvement in drug release of Ketoprofen as compared to the pure drug. Methods: Ketoprofen crystals were prepared by solvent evaporation, a conventional method, with an excipient, saccharin sodium dihydrate at room temperature. Control batch of Ketoprofen was prepared by excluding the excipient in the preparation. The prepared crystals were converted to directly compressible tablet dosage form. Results: The crystal formation of Ketoprofen lead to improve the compressibility, mechanical properties, and tensile strength of the drug which enable to prepare directly compressible tablet dosage form. The In-vitro study demonstrated 2.71 fold increase in the drug release rate from tablets of Ketoprofen crystals compared to the pure drug after one hour. The characterization was done by Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), Powder X-Ray Diffractometry (pXRD), and Headspace Gas Chromatography (HSGC) study of Ketoprofen treated crystals illustrated the improvement in physicochemical, manufacturability, and pharmacotechnical parameters of Ketoprofen. Conclusions: The crystal engineering approach can be used to improve the physicomechanical and pharmacotechnical parameters of BCS Class-II drugs which enable to prepare directly compressible tablet dosage form. © 2020 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Vaghela, P.D.; Tank, H.M. Preparation and evaluation of directly compressible tablets of ketoprofen crystals. Indo Global J. Pharm. Sci., 2020; 10(3): 21-34. DOI: http://doi.org/10.35652/IGJPS.2020.10303 . Indo Global Journal of Pharmaceutical Sciences, 2020; 10(3): 21-34 22 Dissolution Study 1. In-Vitro drug release study of directly compressible tablets of pure drug, its control batch, and Ketoprofen

目的:制备酮洛芬晶体直接可压片，并评价其与纯药相比对酮洛芬释药的改善作用。方法:以二水合糖精钠为辅料，采用常规溶剂蒸发法制备酮洛芬结晶。采用不含辅料的方法制备酮洛芬对照批。将制备的晶体转化为可直接压缩片剂剂型。结果:酮洛芬晶体的形成改善了药物的可压缩性、力学性能和抗拉强度，可直接制备可压缩片剂剂型。体外研究表明，酮洛芬晶体片剂在1小时后的药物释放率比纯药物增加2.71倍。通过扫描电镜(SEM)、差示扫描量热法(DSC)、粉末x射线衍射(pXRD)和顶空气相色谱(HSGC)对酮洛芬处理后的晶体进行了表征，表明酮洛芬在物理化学、可制造性和药物技术参数方面得到了改善。结论:晶体工程方法可改善BCSⅱ类药物的物理力学参数和药物技术参数，使其可直接制备可压缩片剂剂型。©2020全球研究与出版基金会。版权所有。引用这篇文章:Vaghela, P.D.;酮洛芬晶体直接可压片的制备与评价。印度国际制药公司。科学。, 2020;10(3):还是。DOI: http://doi.org/10.35652/IGJPS.2020.10303。印度全球药物科学杂志，2020;22溶解度研究纯药直接可压片、对照批及酮洛芬的体外释放研究

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引用次数: 0

Viral Diseases, N-COVID-19, and Evolution: A Commentary 病毒性疾病，N-COVID-19和进化:评论

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2020-01-01 DOI: 10.35652/IGJPS.2020.10203

S. Ghosh

Viruses originated from 'Primordial Nucleic Acids' with lipid and protein encapsulations. Chance fusion with cellular entities and intracellular replication of exogenotes started the journey of viruses on this planet. While replicating, pairing occurred in between the viral exogenotes and the host endogenote at their homologous sites. Therefore, both of the genes become recombined. Sometimes the viral exogenotes get integrated into the host genome resulting in a new reading frame in gene sequences. So, at every cycle of cellular infection with a viral particle, both the host and the parasite genes are recombined. The virulent the viral infection, the better is the chance of gene recombination of the host. Every stratum of cellular living forms has its viral pathogen. In lower living forms, depending on the habitats, a complete gene or its fragments may enter a cell using membrane receptors from the nucleic acid pool resulted from the lysis of cellular entities or viral particles, and gene recombination occurs. These are Transforming Principles or Transposable Elements. This lateral passage of genes through individuals is called Horizontal Gene Transfer. When mediated by viruses, it is called Transduction. Eventually, gene recombination occurs at the cellular level. Genetic Recombination is the basis of speciation, survival, evolution, and a way out of genetic bottleneck in cellular life. Humans too are facing a genetic bottleneck and living on the edge of extinction. Therefore, the viral infections in humans might be one of mother nature's designs to find a way out of this genetic bottleneck and survive and evolve further. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.

病毒起源于带有脂质和蛋白质包封的“原始核酸”。与细胞实体的偶然融合和外源基因的细胞内复制开始了病毒在这个星球上的旅程。在复制过程中，病毒外源基因和宿主内源基因在同源位点上发生配对。因此，两个基因都重新组合。有时，病毒外源基因会整合到宿主基因组中，从而在基因序列中形成新的阅读框。因此，在病毒颗粒感染细胞的每一个周期中，宿主和寄生虫的基因都会重组。病毒感染的毒性越强，宿主基因重组的机会就越大。细胞生命形式的每一层都有其病毒病原体。在低等生命形式中，根据生存环境的不同，一个完整的基因或其片段可能通过细胞实体或病毒颗粒裂解产生的核酸池中的膜受体进入细胞，并发生基因重组。这些是变换原则或转座元素。这种基因通过个体的横向传递被称为水平基因转移。当由病毒介导时，称为转导。最终，基因重组发生在细胞水平。基因重组是物种形成、生存和进化的基础，也是细胞生命摆脱遗传瓶颈的途径。人类也面临着遗传瓶颈，生活在灭绝的边缘。因此，人类的病毒感染可能是大自然母亲的设计之一，以找到摆脱这种遗传瓶颈的方法，并进一步生存和进化。©2020全球研究与出版基金会。版权所有。

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引用次数: 0

Pharmacological Effects of Physalis minima Linn 小檗的药理作用

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2019-01-01 DOI: 10.35652/igjps.2019.92s35

Mandeep S. Singh

引用次数: 0

Therapeutic Management of AIDS using Ethnomedicinal Plants 民族药材治疗艾滋病的管理

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2019-01-01 DOI: 10.35652/igjps.2019.92s41

R. Kaur, Pooja Sharma, Dinesh Kumar

Acquired Immunodeficiency Syndrome (AIDS) which is chiefly originated by a retrovirus named as Human Immunodeficiency Virus (HIV), has influenced about 70 million populations worldwide. Even though several advancements have been invented in the field of antiretroviral combination therapy, still HIV has become the dominant reason of death in South Africa. The current antiretroviral therapies have achieved success in providing instant HIV suppression but with countless undesirable adverse effects. In the present day, the biodiversity of plant kingdom is being explored by several researchers for the discovery of potent anti-HIV drugs with different mechanisms of action. The primary challenge is to afford a treatment that is free from any sort of risk of the drug resistance and serious side effects. Hence, there is a strong demand to evaluate the drugs obtained from natural plants as well as the synthetic derivatives that have been derived from the natural compounds by various chemical reactions. Several natural plants such as Andrographis paniculata, Dioscorea bulbifera, Aegle marmelos, Wistaria floribunda, Lindera chunii, Xanthoceras sorbifolia and others have displayed significant anti-HIV activity and were researched for their therapeutic principles. The synthetic derivatives of natural compounds have shown more potent anti-HIV potential with improved pharmacokinetic profile. These include the synthetic derivatives of artemisinin, andrographolide, calanolides, maslinic acid and ingenol synthetic derivatives. © 2019 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Kaur, R.; Sharma, P.; Kumar, D. Therapeutic Management of AIDS using Ethnomedicinal Agents. Indo Global J. Pharm. Sci., 2019; 9(2Suppl.): 143. DOI: http://doi.org/10.35652/IGJPS.2019.92S41 . Indo Global Journal of Pharmaceutical Sciences( ISSN 2249 1023; CODENIGJPAI; NLM ID: 101610675) indexed and abstracted in CrossRef (DOI Enabling), UGC CARE Journal List, EMBASE(Elsevier), National Library of Medicine (NLM) Catalog, ResearchGate, Publons, CAS (ACS), Index Copernicus, Google Scholar and many more. For further details, visit http://iglobaljournal.com This is a special issue as an outcome of ‘RAPSCON-2019’ sponsored by APTI and organized by Sri Sai College of Pharmacy, Manawala, Amritsar, Punjab, India. Relaxation offered in journal format.

获得性免疫缺陷综合症(艾滋病)主要由一种名为人类免疫缺陷病毒(HIV)的逆转录病毒引起，影响了全世界约7000万人。尽管在抗逆转录病毒联合疗法领域取得了若干进展，但艾滋病毒仍然成为南非死亡的主要原因。目前的抗逆转录病毒疗法在提供即时艾滋病毒抑制方面取得了成功，但也带来了无数不良反应。目前，一些研究人员正在探索植物界的生物多样性，以发现具有不同作用机制的强效抗hiv药物。主要的挑战是提供一种没有任何耐药风险和严重副作用的治疗方法。因此，人们迫切需要对从天然植物中获得的药物以及通过各种化学反应从天然化合物中获得的合成衍生物进行评估。一些天然植物如穿心莲、黄花薯蓣、蜜桔、紫藤、秋葵、文冠果等都显示出显著的抗hiv活性，并对其治疗原理进行了研究。天然化合物的合成衍生物具有更好的药代动力学特征，显示出更强的抗hiv潜力。这些包括青蒿素、穿心莲内酯、calanolides、maslin酸和ingenol合成衍生物的合成衍生物。©2019 igglobal研究与出版基金会。版权所有。引用本文如下:Kaur, R.;沙玛,p;民族药物在艾滋病治疗管理中的应用。印度国际制药公司。科学。, 2019;9(2生理):143。DOI: http://doi.org/10.35652/IGJPS.2019.92S41。印度全球药物科学杂志(ISSN 2249 1023;CODENIGJPAI;NLM ID: 101610675)在CrossRef (DOI Enabling)， UGC CARE Journal List, EMBASE(Elsevier)， National Library of Medicine (NLM) Catalog, ResearchGate, Publons, CAS (ACS)， Index哥白尼，Google Scholar等中索引和摘要。欲了解更多详情，请访问http://iglobaljournal.com这是由APTI赞助，印度旁遮普阿姆利则马纳瓦拉斯里赛药学院组织的“RAPSCON-2019”的特刊。以日志形式提供放松。

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引用次数: 0

Exploration of Therapeutic Efficacy of Withania somnifera and Curcuma longa In Alzheimer’s disease - A Boon Withania somnifera和姜黄longa治疗阿尔茨海默病的疗效探讨

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2019-01-01 DOI: 10.35652/igjps.2019.92s42

Rajat V. Sarin, S. Sharma

Alzheimer ’s disease (AD) is an age related, irreversible neurodegenerative disease which is characterized by severe memory loss, unusual behavior, personality changes and a decline in cognitive function. The main pathological hallmark of AD is decreased level of acetylcholine (Ach) and increase amyloid beta (Aβ) plaque deposition, neurofibrillary tangle (NFT) formation and decrease brain-derived neurotrophic factor (BDNF) in hippocampus area of brain. Some ayurvedic medicinal plants are proved as a boon in the treatment of AD. Ayurvedic medicinal plants have been the single most productive source for the development of new drugs over already existing allopathic medicines. Indeed, several scientific studies have described the use of Withania somnifera and Curcuma longa as potential treatment for AD. Aqueous extract of this herb has been found to increase memory by increasing cholinergic activity, decreasing Aβ plaque deposition due to presence of withanamides. The active chemical constituents of Curcuma longa i.e.; curcumin reduces the amount of Aβ plaque deposition. This review summarizes the therapeutic efficacy of Withania somnifera and Curcuma longa in treatment of Alzheimer’s Disease. © 2019 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Sarin, R.; Sharma, S. Exploration of Therapeutic Efficacy of Withania somnifera and Curcuma longa In Alzheimer’s disease A Boon. Indo Global J. Pharm. Sci., 2019; 9(2Suppl.): 144. DOI: http://doi.org/10.35652/IGJPS.2019.92S42 . Indo Global Journal of Pharmaceutical Sciences( ISSN 2249 1023; CODENIGJPAI; NLM ID: 101610675) indexed and abstracted in CrossRef (DOI Enabling), UGC CARE Journal List, EMBASE(Elsevier), National Library of Medicine (NLM) Catalog, ResearchGate, Publons, CAS (ACS), Index Copernicus, Google Scholar and many more. For further details, visit http://iglobaljournal.com This is a special issue as an outcome of ‘RAPSCON-2019’ sponsored by APTI and organized by Sri Sai College of Pharmacy, Manawala, Amritsar, Punjab, India. Relaxation offered in journal format.

阿尔茨海默病(AD)是一种与年龄相关的、不可逆的神经退行性疾病，其特征是严重的记忆丧失、异常行为、人格改变和认知功能下降。阿尔茨海默病的主要病理标志是乙酰胆碱(Ach)水平降低，脑海马区β淀粉样蛋白(Aβ)斑块沉积、神经原纤维缠结(NFT)形成增加，脑源性神经营养因子(BDNF)减少。一些阿育吠陀药用植物被证明对治疗阿尔茨海默病有好处。阿育吠陀药用植物是开发新药的唯一最有效的来源，而不是已经存在的对抗疗法药物。事实上，一些科学研究已经描述了使用Withania somnifera和Curcuma longa作为AD的潜在治疗方法。这种草药的水提取物已被发现通过增加胆碱能活性来增加记忆，减少由于存在的戊烷酰胺而导致的Aβ斑块沉积。姜黄的有效化学成分为;姜黄素减少了Aβ斑块沉积的数量。本文综述了Withania somnifera和Curcuma longa治疗阿尔茨海默病的疗效。©2019 igglobal研究与出版基金会。版权所有。引用本文如下:Sarin, R.;沙玛，S.苦参与姜黄治疗阿尔茨海默病的疗效探讨[j]。印度国际制药公司。科学。, 2019;9(2生理):144。DOI: http://doi.org/10.35652/IGJPS.2019.92S42。印度全球药物科学杂志(ISSN 2249 1023;CODENIGJPAI;NLM ID: 101610675)在CrossRef (DOI Enabling)， UGC CARE Journal List, EMBASE(Elsevier)， National Library of Medicine (NLM) Catalog, ResearchGate, Publons, CAS (ACS)， Index哥白尼，Google Scholar等中索引和摘要。欲了解更多详情，请访问http://iglobaljournal.com这是由APTI赞助，印度旁遮普阿姆利则马纳瓦拉斯里赛药学院组织的“RAPSCON-2019”的特刊。以日志形式提供放松。

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引用次数: 0

A Preliminary Survey on Home and Kitchen Herbal Remedies for Primary Health Care at Bichkunda, Kamareddy District, Telangana State 在泰伦加纳邦卡马雷迪区比昆达对初级保健家庭和厨房草药的初步调查

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2019-01-01 DOI: 10.35652/igjps.2019.9205

D. Rajesh, Ahmed Khan

: The present paper focused on traditional medicine system like folk medicine, sida, unani, ayurvedha and homeopathy practice with in the home and kitchen herbal remedies for primary health care. Traditional medicine practicing from generations to generations for hundreds of years. Thousands of years of traditional medicine can gives valuable information about our daily life. The traditional medicine system depends large number of medicinal plant species and animal species. For knowing of traditional knowledge we were conducted the surveyed (June-2018 to December-2018) local people and tribal people,

:本论文重点介绍了传统医学系统，如民间医学、西达、乌纳尼、阿育吠陀和顺势疗法，在家庭和厨房中使用草药进行初级卫生保健。传统医学代代相传数百年。几千年的传统医学可以为我们的日常生活提供有价值的信息。传统医药体系依赖于大量的药用植物物种和动物物种。为了了解传统知识，我们对当地人和部落人进行了调查(2018年6月至2018年12月)，

引用次数: 2

Potential Effects of Phytoconstituents in Symptomatic Relief of Alzheimer’s Disease 植物成分在阿尔茨海默病症状缓解中的潜在作用

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2019-01-01 DOI: 10.35652/igjps.2019.92s12

Rakesh Kumar, Rajan Kumar, N. Sharma, N. Khurana

Phytoconstituents are obtained from the various plant sources that are known for symptomatic relief of Alzheimer’s disease (AD). The phytoconstituents such as hesperidin, huperizine A, curcumin, quercetin, rutin, magnolol, myrcene, vanillic acid, gastrodin, rasmarinic acid, myricetin and other are reported to show symptomatic relief in treatment of AD. The AD is a neurodegenerative disorder that is characterized by chronic progressive loss of neuron, function or death of cell in brain. The Aggregation of amyloid-β (Aβ) and Neurofibrillary Tangles (NFTs) are two major hallmarks in hippocampus and cortex region of the brain, occurred by enhancement of β-secretase enzyme, lipid peroxidation (LPO), reactive oxygen species (ROS), acetylcholinestrase (AChE) enzyme and decrease of antioxidant defence enzymes such as glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) enzyme. The various research have been reported that phytoconstituents showed attenuation of β-secretase, LPO, ROS, AChE enzyme and amelioration of antioxidant defence enzymes. Phytoconstituents, also showed anti-inflammatory activities by reducing neuroinflammation. In this review, phytoconstituents are reported to show the potential effect in symptomatic relief of the AD.© 2019 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Kumar, R.; Kumar, R.; Sharma, N.; Khurana, N. Potential effects of phytoconstituents in symptomatic relief of alzheimer’s disease. Indo Global J. Pharm. Sci., 2019; 9(2Suppl.): 114. DOI: http://doi.org/10.35652/IGJPS.2019.92S12 . Indo Global Journal of Pharmaceutical Sciences( ISSN 2249 1023; CODENIGJPAI; NLM ID: 101610675) indexed and abstracted in CrossRef (DOI Enabling), UGC CARE Journal List, EMBASE(Elsevier), National Library of Medicine (NLM) Catalog, ResearchGate, Publons, CAS (ACS), Index Copernicus, Google Scholar and many more. For further details, visit http://iglobaljournal.com This is a special issue as an outcome of ‘RAPSCON-2019’ sponsored by APTI and organized by Sri Sai College of Pharmacy, Manawala, Amritsar, Punjab, India. Relaxation offered in journal format.

植物成分是从各种植物来源获得的，已知可缓解阿尔茨海默病(AD)的症状。据报道，橙皮苷、石杉碱A、姜黄素、槲皮素、芦丁、厚朴酚、月桂素、香草酸、天麻素、rasmaric酸、杨梅素等植物成分在治疗AD中表现出症状缓解。阿尔茨海默病是一种神经退行性疾病，以慢性进行性神经元丧失、功能丧失或脑细胞死亡为特征。淀粉样蛋白-β (Aβ)和神经原纤维缠结(nft)的聚集是大脑海马和皮质区的两个主要特征，其发生方式是β-分泌酶、脂质过氧化(LPO)、活性氧(ROS)、乙酰胆碱酯酶(AChE)酶的增强和抗氧化防御酶如谷胱甘肽(GSH)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH- px)、过氧化氢酶(CAT)酶的减少。各种研究报道，植物成分具有抑制β-分泌酶、LPO、ROS、AChE酶和改善抗氧化防御酶的作用。植物成分也表现出抗炎活性，通过减少神经炎症。在这篇综述中，植物成分被报道显示出对AD症状缓解的潜在作用。©2019 igglobal研究与出版基金会。版权所有。引用本文为:Kumar, R.;库马尔,r;沙玛:;植物成分在阿尔茨海默病症状缓解中的潜在作用。印度国际制药公司。科学。, 2019;9(2生理):114。DOI: http://doi.org/10.35652/IGJPS.2019.92S12。印度全球药物科学杂志(ISSN 2249 1023;CODENIGJPAI;NLM ID: 101610675)在CrossRef (DOI Enabling)， UGC CARE期刊列表，EMBASE(爱思唯尔)，国家医学图书馆(NLM)目录，ResearchGate, Publons, CAS (ACS)， Index Copernicus，谷歌Scholar等中索引和摘要。欲了解更多详情，请访问http://iglobaljournal.com这是由APTI赞助，印度旁遮普阿姆利则马纳瓦拉斯里赛药学院组织的“RAPSCON-2019”的特刊。以日志形式提供放松。

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