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An Online Knowledge-Attitude-Practice Survey in the Community about Adult Hypertension from Eastern India 印度东部社区成人高血压知识-态度-行为在线调查
Pub Date : 2023-01-01 DOI: 10.37506/ijphrd.v14i4.19833
Background: To address the reasons for hypertension disease burden it is important to understand the knowledge,attitude, and practices (KAP) of all pertinent stakeholders including the community. This study explored theperception in the community regarding the burden of hypertension in India as this is lacking in Indian studies.Methods: A cross-sectional survey was conducted through online mode in India using a validated, field-testedquestionnaire incorporating KAP domain questions regarding hypertension. Scores to questions were appropriatelyassigned.Results: The mean (SD) age of the respondents was 28.49 (7.508) years (n=225). The median (IQR) KAP scoreswere measured out of a maximum of 18, 5 and 4, respectively. Higher educational and socioeconomic levels wereassociated with better attitude scores, but knowledge levels were comparable. Correlations between KAP scoreswere poor.Conclusions: This study reveals that laypersons in the community have appropriate knowledge and attituderegarding hypertension to some extent but there are important lacunae and practices are often found wanting.These issues need to be addressed through sustained public sensitization and motivational campaigns to improvethe future and treatment outcomes of hypertension in India.
背景:为了解决高血压疾病负担的原因,了解包括社区在内的所有相关利益相关者的知识、态度和实践(KAP)是很重要的。本研究探讨了印度社区对高血压负担的看法,因为这在印度研究中是缺乏的。方法:在印度通过在线模式进行横断面调查,使用经过验证的现场测试问卷,其中包含有关高血压的KAP领域问题。问题的分数是适当分配的。结果:被调查者的平均(SD)年龄为28.49(7.508)岁(n=225)。KAP的中位数(IQR)评分分别为18,5和4。较高的教育程度和社会经济水平与较高的态度得分相关,但知识水平具有可比性。KAP评分之间的相关性较差。结论:本研究表明,社会上的外行人对高血压有一定的认识和态度,但存在重要的空白和实践不足。这些问题需要通过持续的公众宣传和激励运动来解决,以改善印度高血压的未来和治疗结果。
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引用次数: 0
A Prospective Study on Surgical Management of Closed Distal End Femoral Fracture in Adults Using Distal Femur Locking Compression Plate 应用股骨远端锁定加压钢板治疗成人闭合性股骨远端骨折的前瞻性研究
Pub Date : 2023-01-01 DOI: 10.37506/ijphrd.v14i4.19827
Background: Distal Femur fractures are a highly incident complex case and pose a challenge to the treatingorthopedician.Aims and Objectives: The aims and objectives of this study were to assess radiological union of distal femoralfractures by open reduction and internal fixation with locking compression plate, To study the functionaloutcome for internal fixation of fractures of the distal end femur by Locking Compression Plate and Toevaluate the effectiveness and complications of distal end femur fractures treated with Locking CompressionPlate based on, time till union, rate of infection, and fixation failures, functional outcome using NEER’S SCORE.Materials and Methods: The present study was done from April 2017 to April 2018 which comprised offifteen patients with closed Distal end Femoral Fractures who where treated by Locking Compression plate.Overall final outcome was assessed in terms of radiological union, clinical assessment and regaining the lostknee function using NEER’S Score.Results: Out of 15 patients, 12 patients were males and 3 patients were females.Out of 15 patients, 14 were due toRTA. Maximum number of cases was of Muller type C2-60%. Internal fixation was considered after patientsgeneral and medical condition was stabilized. The average operative time was 90 minutes. The size of plate wasselected based on the type of fracture. 6 to 10 hole plate were used most commonly. Of 15 patients, 10(66.66%)showed radiological union within 16 weeks. 9 (60%) of the patients achieved weight bearing at the end of 14weeks. Average flexion in this study was 100 degree with more than 3 (20%) patients having knee range ofmotion more than 110 degree. 1 Patient had stiff knee. More than 80% patients were extensor lag less than 5degree. 2 patients had VARUS MALALIGNMENT out of 15 patients.Results according to NEER’S SCORE wereExcellent in 20% patients, Good in 60% , Satisfactory in 6.6% and unsatisfactory in 13.3% patients. 2 patients hadsuperficial infection and 1 patient had delayed union.Conclusion: Locking compression plate is an optimal tool for Distal end femoral fractures. It provides rigidfixation in the region of femur, where a wide canal, thin cortices and frequently poor bone stock make fixationdifficult.
背景:股骨远端骨折是一种高度偶然性的复杂病例,对骨科医生的治疗提出了挑战。宗旨及目标:本研究的目的和目的是评估股骨远端骨折切开复位和锁定加压钢板内固定的放射学愈合,研究锁定加压钢板内固定股骨远端骨折的功能结果,并根据愈合时间、感染率和固定失败率评估锁定加压钢板治疗股骨远端骨折的疗效和并发症。功能结果采用never’s评分。材料与方法:本研究于2017年4月至2018年4月完成,包括15例闭合性股骨远端骨折患者,均采用锁定加压钢板治疗。使用NEER 'S评分评估放射学愈合、临床评估和膝关节功能恢复的总体最终结果。结果:15例患者中,男性12例,女性3例。在15名患者中,14名患者接受了toRTA治疗。最大病例数为Muller型C2-60%。在患者一般情况和病情稳定后考虑内固定。平均手术时间为90分钟。根据骨折类型选择钢板的尺寸。最常用的是6 ~ 10孔板。15例患者中,10例(66.66%)在16周内放射愈合。9例(60%)患者在14周结束时达到体重。本研究的平均屈曲度为100度,超过3例(20%)患者膝关节活动范围超过110度。1患者膝关节僵硬。80%以上患者伸肌滞后小于5度。15例患者中2例出现内翻畸形。NEER’s评分结果:优20%,良60%,满意6.6%,不满意13.3%。2例发生浅表感染,1例延迟愈合。结论:锁定加压钢板是治疗股骨远端骨折的最佳工具。它在股骨区域提供刚性固定,在该区域,宽管、薄皮质和通常较差的骨存量使固定变得困难。
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引用次数: 0
The Relationships of Paranormal Beliefs and Locus of Control among Students of Medical College, Delhi 德里医学院学生超自然信仰与控制源的关系
Pub Date : 2023-01-01 DOI: 10.37506/ijphrd.v14i4.19825
Background: The phenomenon of Paranormal beliefs has puzzled scientific community. Studies on this subjecthave been hindered by conceptual and methodological issues. There is little evidences found between locus ofcontrol and paranormal. This constituted rationale of current study. We studied relationships between paranormalbeliefs, as measured by Paranormal Belief Scale (Tobacyk& Milford, 1983) and locus of control as measured byROT-IE scale among medical students of Delhi.Methodology: The study population consists of medical undergraduate students in Delhi who were enrolled atcollege during the time of the study. All undergraduate students who gave consent were included in study. A pretestedand predesigned questionnaire asking their socio-demographic information and relationship between theirsense of personal control(locus of control measured by the ROT-IE scale) and paranormal beliefs(using revisedform of the Paranormal Belief Scale) was administered. Chi-square test and Pearson’s correlation test were usedto test significanceResults: Means and standard deviations for the PBS-R and the IELOC Scales were reported separately for sociodemographicparameters. Females scored higher than males on all subscale except extraordinary life formsand precognition but it was statistically significant. Bi-variate correlation between locus of control and revisedparanormal belief scale revealed that as persons tend towards internal locus of control, their paranormal beliefbecome low.Conclusion: In our study it was shown that there was significant relationships among paranormal beliefs and locusof control.
背景:超自然信仰现象一直困扰着科学界。关于这个问题的研究受到概念和方法问题的阻碍。几乎没有证据表明控制点与超自然现象之间存在联系。这构成了本研究的基本原理。我们研究了超自然信仰之间的关系,用超自然信仰量表(Tobacyk&Milford, 1983)和控制点,以rot - ie量表在德里医科学生中测量。方法:研究人群包括在研究期间在德里大学注册的医学本科生。所有同意的本科生都被纳入研究。使用一份预先测试和预先设计的问卷,询问他们的社会人口统计信息以及他们的个人控制感(由ROT-IE量表测量的控制点)与超自然信仰(使用修订的超自然信仰量表)之间的关系。结果:PBS-R量表和IELOC量表的社会人口学参数分别报告均数和标准差。除了非凡的生命形式和预知外,女性在所有分量表上的得分都高于男性,但有统计学意义。控制点与修订后的超自然信念量表的双变量相关分析表明,当个体倾向于内在控制点时,其超自然信念会降低。结论:我们的研究表明,超自然信念与控制中心之间存在显著的关系。
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引用次数: 0
Traditional Dietary Practices and Related Taboos during Menstruation among Women of Rural Households in Haryana: A Qualitative Study 哈里亚纳邦农村家庭妇女经期传统饮食习惯及相关禁忌:一项定性研究
Pub Date : 2023-01-01 DOI: 10.37506/ijphrd.v14i4.19826
Background: Women imbibe many myths, taboos, and practices about food during menstruation. The socioculturalmilieu of Indian society can explain the notions of menstrual restrictions. Aim: To know the traditionaldietary practices and related taboos during menstruation among women of rural households in Sonepat, Haryana.Material and Methods: This community-based cross-sectional study was conducted among 90 households invillage Juan, Haryana selected by systematic random sampling from July 2021 to June 2022. Data regardingtraditional dietary practices and related taboos during menstruation among women at the household level werecollected using an open-ended questionnaire from a woman from each selected household after written informedconsent. Data were analyzed using SPSS version 20.Results: Mean age (SD) of the study participants was 44.1 (14) years with a range from 18-85 years. Two-thirds(66.7%) of study households reported avoidance of buttermilk/curd and pickles due to the belief of an increase inpain and cramps on consumption. One-third of study households preferred hot beverages such as tea (37.8%) andtea with clarified butter (31.1%) believing that pain and cramps get relieved, and clarified butter provides strengthto the body.Conclusion: There are a number of dietary practices and related taboos prevalent among study households thatmay affect mental health.
背景:女性在月经期间吸收了许多关于食物的神话、禁忌和习俗。印度社会的社会文化环境可以解释月经限制的概念。目的:了解哈里亚纳邦索内帕特农村家庭妇女经期的传统饮食习惯及禁忌。材料与方法:本研究采用系统随机抽样方法,于2021年7月至2022年6月对哈里亚纳邦胡安村的90户家庭进行了以社区为基础的横断面研究。在获得书面知情同意后,使用开放式问卷从每个选定家庭的一名妇女那里收集有关月经期间妇女传统饮食习惯和相关禁忌的数据。数据分析采用SPSS version 20。结果:研究参与者的平均年龄(SD)为44.1(14)岁,年龄范围为18-85岁。三分之二(66.7%)的受调查家庭报告说,由于相信食用酪乳/豆腐和泡菜会增加疼痛和抽筋,他们避免食用酪乳/豆腐和泡菜。三分之一的受调查家庭更喜欢热饮,如茶(37.8%)和加澄清黄油的茶(31.1%),他们认为澄清黄油可以缓解疼痛和痉挛,并为身体提供力量。结论:研究家庭中普遍存在的一些饮食习惯和相关禁忌可能影响心理健康。
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引用次数: 0
Predictors of Social Isolation and Loneliness among Elderly Residing in a Slum in Eastern India 东印度贫民窟老年人社会隔离和孤独的预测因素
Pub Date : 2023-01-01 DOI: 10.37506/ijphrd.v14i4.19750
Background: Geriatric population in India is expected to reach about 20% of total population by 2050.4,5 Thisbrings along newer challenges of not only physical morbidities, but psychosocial morbidities too for this groupof population. Social withdrawal and isolation, loneliness are two of those mental morbidities of concern. Socialisolation is an objective state defined as the absence of contact with other people and integration with othermembers of society.6 In contrast, loneliness is a subjective feeling caused by ‘being without some definite neededrelationship or set of relationships’7. Social isolation & loneliness both have impact on physical and mental wellbeing of a person.10-16 So, present study was conducted with the objective of assessing the extent of loneliness andsocial isolation among elderly in an urban community, and determining the covariates of the same.Methods: This cross-sectional community-based study was undertaken from December 2019 to February 2020among 246 elderly men and women, 60 years & above residing in a slum in Chetla Kolkata. They were interviewedabout their demographic, financial supports and social supports. Social Isolation was assessed with the help ofsix item Lubben Social network scale-6.17,18 Loneliness was assessed with the help of the UCLA Loneliness Scaleversion 3.19,20 Statistical Analysis: Descriptive and univariate analysis, multiple logistic regression was done tofind out factors associated with loneliness & social isolation.Results: Social isolation and loneliness were present in 120 (48.78%) and 125 (50.81%) subjects respectively.Multivariate logistic regression revealed that age>69 years. marital status other than married, inadequate income,and those living alone were at increased risk of social isolation. Inadequate income and male sex were at greaterrisk of loneliness.Conclusion: Social isolation & loneliness are present in almost half of the elderly living in an urban slum ofKolkata, which is alarming
背景:到2050年,印度的老年人口预计将达到总人口的20%左右,这给这一人群带来了新的挑战,不仅是身体发病率,还有社会心理发病率。社会退缩和孤立,孤独是两种值得关注的精神疾病。5 .社会孤立是一种客观状态,其定义为缺乏与其他人的接触和与社会其他成员的融合相比之下,孤独是一种主观的感觉,由“没有某种明确需要的关系或一组关系”引起。社会孤立&;孤独对一个人的身心健康都有影响。因此,本研究的目的是评估城市社区老年人的孤独和社会隔离程度,并确定其协变量。方法:本横断面社区研究于2019年12月至2020年2月在246名60岁及以上的老年男女中进行。而不是住在加尔各答的贫民窟。他们接受了关于人口统计、经济支持和社会支持的采访。孤独感评估采用六项Lubben社会网络量表(6.17,18);孤独感评估采用UCLA孤独感量表(3.19,20);统计分析:采用描述性分析、单因素分析、多元逻辑回归等方法,探讨孤独感的影响因素;社会隔离。结果:社会隔离和孤独感分别为120例(48.78%)和125例(50.81%)。多因素logistic回归显示年龄为69岁。已婚以外的婚姻状况、收入不足和独居者面临社会孤立的风险增加。收入不足和男性更容易感到孤独。结论:社会孤立;生活在加尔各答城市贫民窟的老人中,有近一半的人感到孤独,这令人担忧
{"title":"Predictors of Social Isolation and Loneliness among Elderly Residing in a Slum in Eastern India","authors":"","doi":"10.37506/ijphrd.v14i4.19750","DOIUrl":"https://doi.org/10.37506/ijphrd.v14i4.19750","url":null,"abstract":"Background: Geriatric population in India is expected to reach about 20% of total population by 2050.4,5 Thisbrings along newer challenges of not only physical morbidities, but psychosocial morbidities too for this groupof population. Social withdrawal and isolation, loneliness are two of those mental morbidities of concern. Socialisolation is an objective state defined as the absence of contact with other people and integration with othermembers of society.6 In contrast, loneliness is a subjective feeling caused by ‘being without some definite neededrelationship or set of relationships’7. Social isolation & loneliness both have impact on physical and mental wellbeing of a person.10-16 So, present study was conducted with the objective of assessing the extent of loneliness andsocial isolation among elderly in an urban community, and determining the covariates of the same.Methods: This cross-sectional community-based study was undertaken from December 2019 to February 2020among 246 elderly men and women, 60 years & above residing in a slum in Chetla Kolkata. They were interviewedabout their demographic, financial supports and social supports. Social Isolation was assessed with the help ofsix item Lubben Social network scale-6.17,18 Loneliness was assessed with the help of the UCLA Loneliness Scaleversion 3.19,20 Statistical Analysis: Descriptive and univariate analysis, multiple logistic regression was done tofind out factors associated with loneliness & social isolation.Results: Social isolation and loneliness were present in 120 (48.78%) and 125 (50.81%) subjects respectively.Multivariate logistic regression revealed that age>69 years. marital status other than married, inadequate income,and those living alone were at increased risk of social isolation. Inadequate income and male sex were at greaterrisk of loneliness.Conclusion: Social isolation & loneliness are present in almost half of the elderly living in an urban slum ofKolkata, which is alarming","PeriodicalId":13368,"journal":{"name":"Indian Journal of Public Health Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135749307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Comparative Study of Serum Lipid Profile in Normal Pregnancy and Pregnancy Induced Hypertension 正常妊娠与妊娠高血压患者血脂水平的比较研究
Pub Date : 2023-01-01 DOI: 10.37506/ijphrd.v14i4.19782
Background: Pregnancy induced hypertension is a significant contributor to maternal and foetal morbidity andmortality worldwide. Studying the lipid profile and risk variables is crucial for illness prevention, management,and a better prognosis.Method and Materials: This study was a case control study conducted in the Department of Obstetrics andGynaecology, Tezpur Medical College and Hospital, Tezpur. A total of 100 (one hundred) were selected, out ofwhich 50 (fifty) normotensive pregnant women served as a control and 50 (fifty) hypertensive women constitutedthe study group. Besides baseline routine investigations, estimation of Serum lipid profile was done by collectingblood samples from antecubital vein of every case and control and were analysed at department of Biochemistry,Tezpur Medical College and Hospital, Tezpur.Results: The hypertensive group had a significant rise in Triglyceride (TG), total cholesterol, LDL-C levels anddecreased HDL-C levels as compared to the control group.Conclusion: Abnormal lipid profile during pregnancy plays an important role in development of pre-eclampsia.
背景:妊娠高血压是全世界孕产妇和胎儿发病率和死亡率的重要因素。研究血脂和风险变量对疾病预防、管理和更好的预后至关重要。方法与材料:本研究为病例对照研究,在提斯浦尔医学院妇产科进行。共选取100例,其中50例血压正常的孕妇为对照组,50例高血压妇女为研究组。除了基线常规调查外,还通过从每个病例和对照组的肘部静脉采集血液样本来估计血清脂质谱,并在提斯浦尔医学院和医院生物化学系进行分析。结果:与对照组相比,高血压组甘油三酯(TG)、总胆固醇、LDL-C水平显著升高,HDL-C水平显著降低。结论:妊娠期血脂异常在子痫前期发生发展中起重要作用。
{"title":"A Comparative Study of Serum Lipid Profile in Normal Pregnancy and Pregnancy Induced Hypertension","authors":"","doi":"10.37506/ijphrd.v14i4.19782","DOIUrl":"https://doi.org/10.37506/ijphrd.v14i4.19782","url":null,"abstract":"Background: Pregnancy induced hypertension is a significant contributor to maternal and foetal morbidity andmortality worldwide. Studying the lipid profile and risk variables is crucial for illness prevention, management,and a better prognosis.Method and Materials: This study was a case control study conducted in the Department of Obstetrics andGynaecology, Tezpur Medical College and Hospital, Tezpur. A total of 100 (one hundred) were selected, out ofwhich 50 (fifty) normotensive pregnant women served as a control and 50 (fifty) hypertensive women constitutedthe study group. Besides baseline routine investigations, estimation of Serum lipid profile was done by collectingblood samples from antecubital vein of every case and control and were analysed at department of Biochemistry,Tezpur Medical College and Hospital, Tezpur.Results: The hypertensive group had a significant rise in Triglyceride (TG), total cholesterol, LDL-C levels anddecreased HDL-C levels as compared to the control group.Conclusion: Abnormal lipid profile during pregnancy plays an important role in development of pre-eclampsia.","PeriodicalId":13368,"journal":{"name":"Indian Journal of Public Health Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135750192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on Knowledge and Atittude about Menstrual Cup and its usuage among Medical Students: A Cross Sectional Study 医学生月经杯及其使用知识态度的横断面研究
Pub Date : 2023-01-01 DOI: 10.37506/ijphrd.v14i4.19830
Introduction: Millions of women globally experience menstruation every month. It is a normal biological process.Inadequate menstrual management has long been a major health issue in low- and middle-income nations, but ithas only recently become a major public health concern. Females may manage menstruation with non-absorbent,unhygienic, and uncomfortable materials due to a lack of awareness, an unfavorable sociocultural environment,logistical and financial barriers, and a lack of a proper support system. Hence this study was undertaken to assessthe knowledge and attitude among medical students.Methodology: This study was conducted among 200 undergraduate female medical students , who were willingto participate in the study. Informed consent was taken and the oral questionnaire which consisted of sociodemographic data and questions regarding knowledge, attitude and practice was distributed. Descriptive analysiswas done by calculating the percentage.Results: 91% of the students were aware of the menstrual cup. A total of 168(84%) students said menstrual cupto be a safe device. A total of 171 (85.5%) students knew that the menstrual cup could be used among virgins.whereas 29 (14.5%) students were of the opinion that it cannot be used by virgins. 84(42%) of students had no ideaabout its associated with TSS (Toxic shock syndrome). 73(36.5%) of students knew that it is not associated withTSS.143(71.5%) said it can’t be used during postpartum and 112(56%) knew that it is used during bathing andswimming.134(67%) students knew that it can’t be used as contraceptives and 88(44%) told it won’t cause ruptureof hymen.Finally in this study we came to know that none of them are using menstrual cup because majority ofthem said that they had fear of using 92(46%) and 51(25.5%) of them said they don’t have adequate knowledge.Conclusion :In this study all the students used sanitary pads, owing to its popularity and promotion. Therewas lack of awareness about the cup and there exists a huge gap between the knowledge and willingness of thestudents to accept the menstrual cup. So, we conclude that menstrual cup needs promotion in India because itis cost effective, eco-friendly and reusable. So, we boost the adoption rate of menstrual cups, youth should betargeted, who are more open to the idea of environment-friendly products.
导读:全球每个月都有数以百万计的女性经历月经。这是一个正常的生物过程。经期管理不足长期以来一直是低收入和中等收入国家的一个主要健康问题,但直到最近才成为一个主要的公共卫生问题。由于缺乏意识、不利的社会文化环境、后勤和经济障碍以及缺乏适当的支持系统,女性可能会使用非吸收性、不卫生和不舒服的材料来管理月经。为此,本研究以医学生为对象,调查医学生的知识与态度。方法:本研究以自愿参加本研究的200名本科女医学生为研究对象。采取知情同意并分发口头调查问卷,其中包括社会人口统计数据以及有关知识、态度和实践的问题。通过计算百分比进行描述性分析。结果:91%的学生知道月经杯的存在。共有168名(84%)学生表示月经杯是一种安全的装置。共有171名(85.5%)学生知道月经杯可以在处女中使用。而29名(14.5%)学生认为处女不能使用。84名(42%)学生不知道其与TSS(中毒性休克综合征)有关。73名(36.5%)学生知道它与tss无关,143名(71.5%)学生知道它不能在产后使用,112名(56%)学生知道它可以在洗澡和游泳时使用,134名(67%)学生知道它不能作为避孕药使用,88名(44%)学生知道它不会导致处女膜破裂。最后,在这项研究中,我们知道没有一个人使用月经杯,因为大多数人说他们害怕使用92(46%),51(25.5%)的人说他们没有足够的知识。结论:由于卫生巾的普及和推广,本研究中所有学生都使用卫生巾。学生对月经杯的认知不足,对月经杯的认知与接受意愿之间存在巨大差距。因此,我们得出结论,月经杯需要在印度推广,因为它具有成本效益、环保和可重复使用。所以,我们提高月经杯的采用率,应该瞄准年轻人,他们对环保产品的想法更开放。
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引用次数: 0
Study of Interleukin-10 Gene Expression in Breast carcinoma in Telangana Population 白细胞介素-10基因在泰伦加纳邦人群乳腺癌中的表达研究
Pub Date : 2023-01-01 DOI: 10.37506/ijphrd.v14i4.19811
Background: Carcinoma breast is the second most common malignancy next to carcinoma cervix in India andabroad. Hence, the expression of IL-10 m-RNA gene in tumour can be a novel prognostic indicator.Method: 30 mastectomy specimens of carcinoma Breast patients aged between 30 to 70 years were studied. 2to 5 gram of tumour tissue and equivalent sample from normal peri-tumoral breast were taken from resectedbreast immediately after surgery and preserved in RNA-later solution. IL-10 m-RNA expression was detectedand quantified by RT-PCR analysis through TaqMan chemistry, on 30 samples and 30 controls. After fixation withformalin 2 micro sections of 4-5micron thickness were taken from tumor area and corresponding paraffin blockswere prepared, mounted, on albumin coated slide for H & E staining and results were observed and recorded.Results: Histologically, 08 specimens were diagnosed as grade-I (26.5%), 16 were grade-II (53.5%) and 06 weregrade-III (20%). 10 specimens (33.5%) had reactive lymph node, and the remaining 20 (66.5%) had metastaticlymph node. Mean RQ values for IL-10 were calculated by the formula for comparative ct (cycle threshold)method. 26 neoplastic tissue specimens (86.5%) showed strong expression of IL-10 mRNA, while only 2 (6.5%)normal peritumoral surrounding tissue showed IL-10 expression. 4 (13.5%) neoplastic tissue and 28 (93.5%) peritumoraltissue showed weak expression of IL-10. All grade 3 tumours showed strong expression of IL-10.Conclusion: Present pragmatic study had evidence that, IL-10 m-RNA gene expression was significant in neoplasticbreast tissue and may have potential prognostic significance.
背景:在印度和国外,乳腺癌是仅次于子宫颈癌的第二常见的恶性肿瘤。因此,il - 10m - rna基因在肿瘤中的表达可作为一种新的预后指标。方法:对30 ~ 70岁乳腺癌患者30例乳房切除术标本进行研究。术后立即切除乳腺取2 ~ 5g肿瘤组织及肿瘤周围正常乳腺等值标本,保存于RNA-later溶液中。采用TaqMan化学RT-PCR方法检测30个样品和30个对照组的IL-10 m-RNA表达。福尔马林固定后,取肿瘤区域4 ~ 5微米厚度的切片2片,制作相应的石蜡块,装于白蛋白包被载玻片上;观察并记录E染色及结果。结果:组织学诊断ⅰ级08例(26.5%),ⅱ级16例(53.5%),ⅲ级06例(20%)。反应性淋巴结10例(33.5%),转移性淋巴结20例(66.5%)。IL-10的平均RQ值采用比较ct(循环阈值)法计算公式。肿瘤组织26例(86.5%)IL-10 mRNA表达强烈,正常瘤周组织仅有2例(6.5%)IL-10 mRNA表达。4例肿瘤组织(13.5%)和28例瘤周组织(93.5%)IL-10表达较弱。所有3级肿瘤均表达IL-10。结论:目前的实际研究表明,il - 10m - rna基因在乳腺肿瘤组织中表达显著,可能具有潜在的预后意义。
{"title":"Study of Interleukin-10 Gene Expression in Breast carcinoma in Telangana Population","authors":"","doi":"10.37506/ijphrd.v14i4.19811","DOIUrl":"https://doi.org/10.37506/ijphrd.v14i4.19811","url":null,"abstract":"Background: Carcinoma breast is the second most common malignancy next to carcinoma cervix in India andabroad. Hence, the expression of IL-10 m-RNA gene in tumour can be a novel prognostic indicator.Method: 30 mastectomy specimens of carcinoma Breast patients aged between 30 to 70 years were studied. 2to 5 gram of tumour tissue and equivalent sample from normal peri-tumoral breast were taken from resectedbreast immediately after surgery and preserved in RNA-later solution. IL-10 m-RNA expression was detectedand quantified by RT-PCR analysis through TaqMan chemistry, on 30 samples and 30 controls. After fixation withformalin 2 micro sections of 4-5micron thickness were taken from tumor area and corresponding paraffin blockswere prepared, mounted, on albumin coated slide for H & E staining and results were observed and recorded.Results: Histologically, 08 specimens were diagnosed as grade-I (26.5%), 16 were grade-II (53.5%) and 06 weregrade-III (20%). 10 specimens (33.5%) had reactive lymph node, and the remaining 20 (66.5%) had metastaticlymph node. Mean RQ values for IL-10 were calculated by the formula for comparative ct (cycle threshold)method. 26 neoplastic tissue specimens (86.5%) showed strong expression of IL-10 mRNA, while only 2 (6.5%)normal peritumoral surrounding tissue showed IL-10 expression. 4 (13.5%) neoplastic tissue and 28 (93.5%) peritumoraltissue showed weak expression of IL-10. All grade 3 tumours showed strong expression of IL-10.Conclusion: Present pragmatic study had evidence that, IL-10 m-RNA gene expression was significant in neoplasticbreast tissue and may have potential prognostic significance.","PeriodicalId":13368,"journal":{"name":"Indian Journal of Public Health Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135748719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of Water, Sanitation and Hygiene (WASH) in Schools of Jammu District- A Cross Sectional Study 查谟地区学校水、环境卫生和个人卫生(WASH)评估——一项横断面研究
Pub Date : 2023-01-01 DOI: 10.37506/ijphrd.v14i4.19760
Background: Provision of safe sanitation services reduces transmission of fecooral diseases, school drop outs,under-nutrition which in turn are important for overall development of children. The study was conducted toevaluate the adequacy of water, sanitation and hygiene (WASH) facilities in schools of rural Jammu.Methodology: A Cross Sectional survey was conducted in 54 (public and private) schools in rural Jammu usingthe questionnaire approved by the Global Task Team for Monitoring WASH in Schools.Results: Piped water was the main source of water supply. Facilities for drinking water were available in allschools. 94.3% schools had 1-9 drinking water points. All schools were doing filtration/chlorination of water. 51%schools reported water and soap availability in girl’s toilets and group hand washing activities were conductedonce a week in 31.5% schools. Toilets were cleaned once per day in 80% of the schools. 88% schools had toiletswithin school premises. Menstrual hygiene materials were available in 42 schools.Conclusions: Environment and sanitation facilities at most of the surveyed schools were reasonably good but notfully satisfactory.
背景:提供安全的环境卫生服务可减少粪便疾病的传播、辍学和营养不良,而这些对儿童的全面发展又很重要。该研究旨在评估查谟农村学校的水、环境卫生和个人卫生(WASH)设施是否充足。方法:在查谟农村的54所学校(公立和私立)进行了横断面调查,使用了全球监测学校讲卫生工作小组批准的问卷。结果:自来水是供水的主要来源。所有学校都有饮水设施。94.3%的学校有1-9个饮水点。所有学校都在对水进行过滤/氯化处理。51%的学校报告说,女厕所提供水和肥皂,31.5%的学校每周开展一次集体洗手活动。80%的学校每天打扫一次厕所。88%的学校校舍内有厕所。42所学校提供经期卫生用品。结论:大多数学校的环境卫生设施还算不错,但并不完全令人满意。
{"title":"Assessment of Water, Sanitation and Hygiene (WASH) in Schools of Jammu District- A Cross Sectional Study","authors":"","doi":"10.37506/ijphrd.v14i4.19760","DOIUrl":"https://doi.org/10.37506/ijphrd.v14i4.19760","url":null,"abstract":"Background: Provision of safe sanitation services reduces transmission of fecooral diseases, school drop outs,under-nutrition which in turn are important for overall development of children. The study was conducted toevaluate the adequacy of water, sanitation and hygiene (WASH) facilities in schools of rural Jammu.Methodology: A Cross Sectional survey was conducted in 54 (public and private) schools in rural Jammu usingthe questionnaire approved by the Global Task Team for Monitoring WASH in Schools.Results: Piped water was the main source of water supply. Facilities for drinking water were available in allschools. 94.3% schools had 1-9 drinking water points. All schools were doing filtration/chlorination of water. 51%schools reported water and soap availability in girl’s toilets and group hand washing activities were conductedonce a week in 31.5% schools. Toilets were cleaned once per day in 80% of the schools. 88% schools had toiletswithin school premises. Menstrual hygiene materials were available in 42 schools.Conclusions: Environment and sanitation facilities at most of the surveyed schools were reasonably good but notfully satisfactory.","PeriodicalId":13368,"journal":{"name":"Indian Journal of Public Health Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135749921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early Diagnosis of Typhoid Fever: Uses of Clinical Profile, Blood Culture and IGM Antibody: A Prospective Study from a Tertiary Care Centre in Western Uttar Pradesh 伤寒的早期诊断:使用临床资料,血液培养和IGM抗体:来自北方邦西部三级保健中心的前瞻性研究
Pub Date : 2023-01-01 DOI: 10.37506/ijphrd.v14i4.19751
Objective:• To study clinical profile of typhoid in children.• To study Comparison of clinical profile and its correlation with blood culture and IgM antibody detection testfor early diagnosis of fever.• To study blood culture and widal at tertiary care centre in western UP.Methods: The study was carried out in Department of Pediatrics, Saraswathi Institute of Medical Sciences, Hapur,UP. All the children presenting with fever, aged from 6 months to 18 years, visited in the pediatric OPD(outpatientdepartment) and IPD(in patient department) of Saraswathi Institute of Medical Sciences from November 2020 toOctober 2022 were included in the study.Results: IgM antibody test was found positive in total 167 cases and negative in 63 cases. Also, blood culture wasreported positive in 157 cases and negative in 73 cases. Out of total positive IgM antibody, 138 showed positivefor blood culture and 29 were reported negative in blood culture. Out of total negative IgM antibody, 19 showedpositive for blood culture and 44 were reported negative in blood culture.Conclusion: Present study shows that typhoid IgM procedure is more sensitive than the established Widalagglutination assay and results can be obtained within 15 minutes while widal agglutination test can be doneafter 1 week. Typhi IgM test can be done after 72 hours of illness as IgM antibody becomes positive after 3 days ofinfection with Salmonella typhi. It is cost effective and can be done bed side.
目的:•研究儿童伤寒的临床特点。•比较临床特征及其与血培养和IgM抗体检测对发热早期诊断的相关性。•在北方邦西部的三级保健中心研究血液培养和widal。方法:本研究在北方邦哈普尔Saraswathi医学科学研究所儿科进行。所有在2020年11月至2022年10月期间在Saraswathi医学科学研究所儿科OPD(门诊部)和IPD(患者部)就诊的6个月至18岁的发烧儿童都被纳入研究。结果:IgM抗体检测167例阳性,63例阴性。此外,157例血培养呈阳性,73例血培养呈阴性。IgM抗体阳性者中,血培养阳性138例,血培养阴性29例。IgM抗体阳性者19例血培养阳性,44例血培养阴性。结论:本研究表明,伤寒IgM程序比已建立的widal凝集试验更敏感,可在15分钟内得到结果,而widal凝集试验可在1周后得到结果。伤寒IgM抗体在感染伤寒沙门菌3天后呈阳性,可在患病72小时后进行检测。它具有成本效益,可以在床边完成。
{"title":"Early Diagnosis of Typhoid Fever: Uses of Clinical Profile, Blood Culture and IGM Antibody: A Prospective Study from a Tertiary Care Centre in Western Uttar Pradesh","authors":"","doi":"10.37506/ijphrd.v14i4.19751","DOIUrl":"https://doi.org/10.37506/ijphrd.v14i4.19751","url":null,"abstract":"Objective:• To study clinical profile of typhoid in children.• To study Comparison of clinical profile and its correlation with blood culture and IgM antibody detection testfor early diagnosis of fever.• To study blood culture and widal at tertiary care centre in western UP.Methods: The study was carried out in Department of Pediatrics, Saraswathi Institute of Medical Sciences, Hapur,UP. All the children presenting with fever, aged from 6 months to 18 years, visited in the pediatric OPD(outpatientdepartment) and IPD(in patient department) of Saraswathi Institute of Medical Sciences from November 2020 toOctober 2022 were included in the study.Results: IgM antibody test was found positive in total 167 cases and negative in 63 cases. Also, blood culture wasreported positive in 157 cases and negative in 73 cases. Out of total positive IgM antibody, 138 showed positivefor blood culture and 29 were reported negative in blood culture. Out of total negative IgM antibody, 19 showedpositive for blood culture and 44 were reported negative in blood culture.Conclusion: Present study shows that typhoid IgM procedure is more sensitive than the established Widalagglutination assay and results can be obtained within 15 minutes while widal agglutination test can be doneafter 1 week. Typhi IgM test can be done after 72 hours of illness as IgM antibody becomes positive after 3 days ofinfection with Salmonella typhi. It is cost effective and can be done bed side.","PeriodicalId":13368,"journal":{"name":"Indian Journal of Public Health Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135748977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Indian Journal of Public Health Research and Development
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