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HERPES ZOSTER DUPLEX BILATERALIS (HZDB) WITH UNUSUAL PRESENTATION IN IMMUNOCOMPROMISED HOST 双侧带状疱疹(Hzdb),在免疫功能低下的宿主中表现不寻常
Pub Date : 2024-05-01 DOI: 10.36106/ijar/1602807
Jincy John Ambalathinkal, Meghana Madhukar Phiske, Shylaja Someshwar
A rare phenomenon of HZ occurring concurrently in two non-contiguous dermatomes involving different halves of thebody is termed herpes zoster duplex bilateralis (HZDB), with incidence < 0.5%, associated with a decline in cellularimmunity,primary/acquired immunodeciencies,and immunosuppressants. Due to decreased cell-mediated immunity, immunocompromisedpatients have a 20-fold increased risk for HZ, occurring at low CD4 count with atypical manifestations. A 49-year-old male had HZ on the rightank with extension to back, erythematous nodules, and plaques arranged in a dermatomal pattern extending from the left angle of mouth to theleft temple for two days with pain and fever. Biopsy from the nodule showed acanthosis, intraepidermal vesiculation caused due to ballooningdegeneration at the base of the vesicle and neutrophils in the dermis s/o HZ. HIV and HBsAG were reactive. Simultaneous reactivation of VZV inmultiple noncontiguous dermatomes requires an immunocompromised milieu, also immunosuppressed patients have atypical presentations.Such patients should undergo a complete immune status evaluation.
双侧带状疱疹(herpes zoster duplex bilateralis,HZDB)是一种罕见的 HZ 同时发生在两个非相邻的皮节(涉及身体的不同部分)的现象,发病率小于 0.5%,与细胞免疫功能下降、原发性/获得性免疫ciencies 和免疫抑制剂有关。由于细胞介导的免疫功能下降,免疫功能低下的患者罹患 HZ 的风险增加了 20 倍,这种疾病在 CD4 细胞计数较低时发生,表现不典型。一名 49 岁男性的 HZ 右ank,扩展到背部,出现红斑结节和斑块,呈皮疹状从左嘴角延伸到左太阳穴,持续两天,伴有疼痛和发热。结节的活组织检查显示有棘皮症,表皮内囊泡因囊泡基部的气球变性而形成,真皮内有中性粒细胞(HZ)。艾滋病毒和 HBsAG 呈反应性。VZV在多个非毗连皮损中同时再激活需要一个免疫功能低下的环境,免疫抑制患者的表现也不典型。
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引用次数: 0
CLINICS –HAS IT REALLY BEEN REPLACED BY MODERN TECHNOLOGY? A QUALITATIVE STUDY. 诊所--真的被现代技术取代了吗?定性研究。
Pub Date : 2024-04-01 DOI: 10.36106/ijar/6902992
A. Chatterjee, Uttam Pal, Abhay Kumar, Vishal Jalan
Background:One of the major concerns of today's medical education is the lack of basic clinical skill and overdependence on investigations among new generation tech savvy doctors. In this study we want to explore the perspectiveof new generation doctors about the relevance of clinics in present day medical practice. The objecti OBJECTIVES: ve of the study was toinvestigate the causes of the dominance of technology over the basic clinical skills in present day medical practice and to nd out the perceivedsolutions of this problem. This study was performed among resident doctors of different clinical bran Materials And Methods: ches working in atertiary health care centre of Eastern India. The study comprised of in-depth interviews and focussed group discussions. The interviews wereaudio recorded and later transcripted. Data analysis was done through deductive approach. Results were reviewed by all the authors. The Results:overdependence on technologies among the new generation doctors are nothing but the reection of changing socioeconomic trends in modernday world. The principal causes are hyposkillia of doctors, commercialization of medical practice, pressure from patient's side, overuse of googleknowledge & excessive misuse of legal means in the name of consumer protection act. Problem is multifactorial and a combined and sustainedeffort is needed for the solution. Lack of clinical skill leads to overdependence on technologies, t Conclusion: hat translates into excessive hightreatment cost and poor patient outcome. Improvement of the clinical skills among present generation doctors can reduce the intensity of theproblem.
背景:当今医学教育的主要关注点之一是新一代技术型医生缺乏基本的临床技能和过度依赖调查。在本研究中,我们希望探讨新一代医生对诊所在当今医疗实践中的相关性的看法。研究目的:本研究的目的是调查当今医疗实践中技术主导地位凌驾于基本临床技能之上的原因,并。这项研究的对象是在印度东部三级医疗保健中心工作的不同临床科室的住院医生。研究包括深入访谈和焦点小组讨论。对访谈进行了录音,随后进行了文字记录。数据分析采用演绎法。所有作者对结果进行了审阅。结果:新一代医生对技术的过度依赖是当今世界社会经济趋势变化的再。其主要原因是医生知识不足、医疗实践商业化、来自患者方面的压力、过度使用谷歌知识以及以消费者保护法为名过度滥用法律手段。问题是多方面的,需要综合、持续的努力来解决。缺乏临床技能导致对技术的过度依赖,最终导致过高的治疗成本和不良的治疗效果。提高当代医生的临床技能可以减少问题的严重性。
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引用次数: 0
STANDARDIZATION OF PORTABLE CULTURE DEVICE FOR ESTIMATION OF TOTAL VIABLE COUNT FROM FOOD SAMPLES 用于估算食品样本总存活数的便携式培养装置的标准化
Pub Date : 2024-04-01 DOI: 10.36106/ijar/9104685
Shveta Tiwari, Varsha Shukla, A. Lokur
Background: Bacterial contamination in food originates from diverse sources, including humans and processingequipment, and often increases during storage, thereby affecting the food quality. Traditional methods for bacterialenumeration involve time-consuming processes, whereas newer techniques such as biosensors offer quicker alternatives at higher costs. Portableculture devices (PCD) have emerged as practical solutions for addressing the need for on-site testing, particularly in resource-limited settings.This study aimed to standardize the use of PCDs to semi-quantify microorganisms in food samples. Via Methods: ble organisms weresuccessfully semi-quantitatively enumerated using enzyme-chromogenic substrate interactions. The de Results: vice, optimized at a substrate-1 concentration of 1 gL and a temperature of 28°C, can detect cell counts of up to 10 CFU/mL. Tests co Conclusion: nducted on experimentallycontaminated food samples, in addition to independent on-site detection without the requirement of typical laboratory facilities, demonstrate thefeasibility of Portable Culture Devices (PCDs) as substitutes for conventional culture-based detection methods. They are appropriate for on-thespot testing in areas with limited resources because they are cost-effective and simple.
背景:食品中的细菌污染来源多种多样,包括人类和加工设备,并经常在储存过程中增加,从而影响食品质量。传统的细菌计数方法需要耗费大量时间,而生物传感器等新技术可以提供更快的替代方法,但成本较高。便携式培养装置(PCD)已成为解决现场检测需求的实用解决方案,尤其是在资源有限的环境中。本研究旨在规范使用 PCD 对食品样本中的微生物进行半定量检测。通过方法:使用酶-色原底物相互作用成功地对微生物进行了半定量计数。结果:在底物-1 浓度为 1 克升、温度为 28 摄氏度的条件下进行优化后,可检测到高达 10 CFU/mL 的细胞数。共同结论:对受实验污染的食品样本进行的测试,以及无需典型实验室设施的独立现场检测,证明了便携式培养设备(PCD)替代传统培养基检测方法的可行性。便携式培养器成本低、操作简单,适合在资源有限的地区进行现场检测。
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引用次数: 0
UNVEILING THE MAGNETIC RESONANCE ENIGMA: DECODING DISTINCTIVE IMAGING FEATURES IN OSTEOFIBROUS DYSPLASIA, FIBROUS DYSPLASIA, AND NONOSSIFYING FIBROMA ACROSS LONG BONES 揭开磁共振之谜:解码长骨骨纤维发育不良、纤维发育不良和非软化纤维瘤的独特成像特征
Pub Date : 2024-04-01 DOI: 10.36106/ijar/0701893
Shubham Wadhwa, Ruchika Singh, Priya Singh, Aditya Agarwal, Nitesh Sharma, Sai Patel, Hem Singh
Background & Objectives: The distinctive magnetic resonance imaging (MRI) characteristics associated withosteobrous. The purpose of this study is to distinguish between OFD, FD, and NOF in long bones using MRIcharacteristics.
背景与目的:与长骨相关的独特磁共振成像(MRI)特征brous。本研究的目的是利用磁共振成像特征区分长骨中的 OFD、FD 和 NOF。
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引用次数: 0
ROLE OF CROSS SECTIONAL IMAGING IN SENSORINEURAL HEARING LOSS 横截面成像在感音神经性听力损失中的作用
Pub Date : 2024-04-01 DOI: 10.36106/ijar/1802832
Manu Gupta, Karan Jyani, Bhumika Luniwal, Heera Ram, Hemnat Kumar Mishra
Purpose: Aims and objective of the study is to determine the incidence of structural cochlear anomalies in Sensorineuralhearing loss and to evaluate them using HRCT and MRI Scan of temporal bone to asses feasibility of cochlearimplantation. The study was carried out in the department of radiodiagnosis over a period of 16 mont Method: hs. The study included 114 patientsof moderate to profound SNHL to evaluate further using HRCT and MRI Scan of temporal bone. Out of t Results: otal 114 pts in our study 75 ptshad normal CT/MRI of temporal bone with no structural abnormalities detected and 39 number of patients had structural malformations whichwere feasible for cochlear implantation. Small percentage of patients (11%) with common cavity and absent cochlear nerve were not feasible forcochlear implantation. HRCT and MR imaging play an important role in evaluation of congenital heari Conclusion: ng loss by providing crucialinformation about the inner ear, vestibulocochlear nerve, and brain. Both modalities precisely and accurately delineate the inner ear anatomy andmalformations preoperatively in cochlear implant patients.
目的:本研究的目的和目标是确定感音神经性失聪患者耳蜗结构异常的发生率,并使用颞骨的 HRCT 和 MRI 扫描对其进行评估,以确定人工耳蜗植入术的可行性。该研究在放射诊断科进行,为期 16 个月。研究纳入了 114 名中度至深度 SNHL 患者,使用颞骨 HRCT 和 MRI 扫描进行进一步评估。结果:在我们研究的 114 名患者中,75 名患者的颞骨 CT/MRI 正常,未发现结构异常,39 名患者存在结构畸形,可以进行人工耳蜗植入。一小部分患者(11%)患有共腔和耳蜗神经缺失,无法进行人工耳蜗植入。结论:HRCT 和 MR 成像通过提供有关内耳、前庭耳蜗神经和大脑的重要信息,在评估先天性听力损失方面发挥着重要作用。这两种成像方式都能在人工耳蜗植入患者术前精确定位内耳解剖结构和畸形。
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引用次数: 0
GREEN ANTI-BIOFILM AGENTS: A MINI-REVIEW 绿色抗生物膜剂:微型综述
Pub Date : 2024-04-01 DOI: 10.36106/ijar/6802147
Shireen Adeeb Mujtaba Ali
Microbial biolm is the polymeric matrix formed by coordinated assembly of species of similar or differentmicroorganisms. The bacteria in form of biolms are more resistant to drugs than compared to their planktoniccounterparts, hence making it difcult to deal with biolm-associated nosocomial and medical device infections. Around $11 billion is annualexpenditure reported to be employed in healthcare to deal with biolm infections but the success rates are very low. Studies on natural anti-biolmagents from the last two decades notably demonstrated their biolm modulation properties. Therefore, present state of affairs demands activepursual for non-toxic natural anti-biolm agents. In this mini-review article, we summarize green anti-biolm agents: antimicrobial peptides(AMPs), phytochemicals, biosurfactants, nanoparticles, and weak organic acids (WOA) with a brief note on their mode of action.
微生物生物lm 是由相似或不同种类的微生物协调组合而成的聚合物基质。与浮游生物相比,以生物lms 形式存在的细菌具有更强的抗药性,因此处理与生物lm 相关的院内感染和医疗器械感染非常困难。据报道,医疗保健领域每年用于应对生物lm 感染的支出约为 110 亿美元,但成功率却非常低。过去二十年对天然抗生物lm 试剂的研究表明,它们具有调节生物lm 的特性。因此,目前需要积极寻求无毒的天然抗生物lm 制剂。在这篇小型综述文章中,我们总结了绿色抗生物lm 制剂:抗菌肽(AMPs)、植物化学物、生物表面活性剂、纳米粒子和弱有机酸(WOA),并简要说明了它们的作用模式。
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引用次数: 0
ENHANCING DISASTER RESILIENCE: A COMPREHENSIVE ANALYSIS OF THE MAHARASHTRA STATE DISASTER MANAGEMENT PLAN 2023 提高抗灾能力:对《2023 年马哈拉施特拉邦灾害管理计划》的全面分析
Pub Date : 2024-04-01 DOI: 10.36106/ijar/7910396
Ashok Uttam Chothe, Vikas Rangnath Garudkar
Disasters pose signicant threats to communities, economies, and ecosystems, necessitating the development andimplementation of robust disaster management plans. Maharashtra, a state with diverse geographical and demographiccharacteristics, has recently formulated its State Disaster Management Plan (SDMP) for the year 2023. This research paper aims to criticallyanalyze and evaluate the key components of the Maharashtra SDMP 2023, assessing its strengths, weaknesses, and potential areas forimprovement. The study utilizes a combination of qualitative and quantitative research methods, incorporating data from ofcial documents,expert interviews, and case studies to provide a comprehensive overview of the state's preparedness and resilience in the face of disasters.
灾害对社区、经济和生态系统构成重大威胁,因此有必要制定和实施强有力的灾害管理计划。马哈拉施特拉邦是一个具有不同地理和人口特征的邦,最近制定了 2023 年邦灾害管理计划 (SDMP)。本研究论文旨在批判性地分析和评估马哈拉施特拉邦 2023 年 SDMP 的关键组成部分,评估其优势、劣势和潜在的改进领域。本研究采用定性和定量相结合的研究方法,结合来自cial 文件、专家访谈和案例研究的数据,全面概述了马哈拉施特拉邦在灾害面前的准备工作和抗灾能力。
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引用次数: 0
ISOLATION OF HIGHER MOLECULAR WEIGHT OF GENOMIC DNA FROM VARIOUS BODY TISSUES OF TASAR SILKWORM, ANTHERAEA MYLITTA DRURY 从塔萨蚕(antheraea mylitta drury)的各种身体组织中分离出较高分子量的基因组 DNA
Pub Date : 2024-04-01 DOI: 10.36106/ijar/4210207
Kumari K, Seraphim E R
In the present study Genomic DNA was isolated from different body tissue of 3 and 5 instars larva and pupae of Tasarsilkworm, Antheraea mylitta Drury. The current article focuses to investigate the various samples for higher molecularweight genomic DNA isolation from Tissues commonly used for molecular studies. The modication was targeted to collect the tissue and theprimary process of genomic DNA isolation. The cationic detergents used and performance was recorded in gel documentation. This articledescribes the best sample to obtain higher molecular weight of genomic DNA from Tasar silkworm.
本研究从 Tasarsilkworm, Antheraea mylitta Drury 的 3 和 5 龄幼虫和蛹的不同身体组织中分离了基因组 DNA。本文重点研究了从分子研究常用组织中分离高分子量基因组 DNA 的各种样本。修改cation的目标是收集组织和基因组 DNA 分离的主要过程。所使用的阳离子洗涤剂及其性能记录在凝胶文件中。本文介绍了从塔沙蚕中获得高分子量基因组DNA的最佳样品。
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引用次数: 0
A STUDY ON COMPARISON OF ACCEPTANCE AND CONTINUATION OF PPIUCD VERSUS CENTCHROMAN IN POSTNATAL WOMEN 一项关于产后妇女接受和继续使用 ppiucd 与 centchroman 的比较研究
Pub Date : 2024-04-01 DOI: 10.36106/ijar/5600633
Yashashwini Mishra, Deepak Anand
Background- Assisting women in maintaining recommended inter-pregnancy intervals is a critical concern formaternal-child health. Centchroman, a non-steroidal selective oestrogen receptor modulator, and postpartum intrauterinecontraceptive device (PPIUCD) is commonly used to provide long-term reversible contraception. To have knowledge regarding acceptance andcontinuation of Centchroman versus PPIUCD among women's of Uttar Pradesh, India this study was carried out. To nd out Objective-1-sociodemographic factors affecting selection for centchroman and PPIUCD among postnatal women's. 2-Compare the side effects andcompliance of PPIUCD versus centchroman pills in postnatal women.3- Compare the satisfaction of PPIUCD versus centchroman pills inpostnatal women. A Prospective study was conducted in the Department of Obstetrics and Gynaecology, Material and Methods: KGMU,Lucknow. Total of 200 womens were enrolled in the study. They were further divided into two groups, i.e., Group-A consenting for PPIUCD useand Group-B consenting for using Centchroman. These women were followed at intervals of 6 weeks, 3 months, 6 months and one year afterdelivery and were investigated for their socio demographic variables, side effects, continuation rate and satisfaction from contraceptive used.Conclusion: Acceptance for PPIUCD was found more in less educated , lower socioeconomic class, unemployed, after caeserian section, andresiding in rural areas women's. Acceptance for centrchroman was more in educated , middle socioeconomic class, employed, after normaldelivery and women's residing in urban area. Continuation rate for centchroman was higher. There was no statistical signicant differenceregarding menstrual abnormalities in both groups, menorrhagia was found statistically signicantly higher in centchroman using group,satisfaction and continuation was found higher in PPIUCD using women's .
背景--帮助妇女维持推荐的孕间隔期是母婴健康的关键问题。非甾体选择性雌激素受体调节剂 Centchroman 和产后宫内避孕器(PPIUCD)通常用于提供长期可逆避孕。为了了解印度北方邦妇女对 Centchroman 和 PPIUCD 的接受程度和停用情况,我们开展了这项研究。 了解目标 1-影响产后妇女选择 Centchroman 和 PPIUCD 的社会人口因素。2-比较 PPIUCD 与 centchroman 避孕药对产后妇女的副作用和依从性。3-比较 PPIUCD 与 centchroman 避孕药对产后妇女的满意度。一项前瞻性研究在勒克瑙 KGMU 妇产科进行:材料和方法:勒克瑙 KGMU。共有 200 名妇女参加了这项研究。她们被分为两组,即同意使用 PPIUCD 的 A 组和同意使用 Centchroman 的 B 组。分别在产后 6 周、3 个月、6 个月和 1 年对这些妇女进行随访,调查她们的社会人口变量、副作用、持续率和对所使用避孕药具的满意度:教育程度较低、社会经济地位较低、失业、剖腹产后和居住在农村地区的妇女对 PPIUCD 的接受度较高。受过教育、属于中等社会经济阶层、有工作、正常分娩后和居住在城市地区的妇女更容易接受 centrchroman。继续使用 centchroman 的比例更高。两组妇女在月经异常方面没有显著的统计学差异,使用 centchroman 组的月经过多率显著高于使用 PPIUCD 组,满意度和持续率也高于使用 PPIUCD 组。
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引用次数: 0
TO STUDY COMMON MUSCULOSKELETAL PROBLEMS IN WORKERS OF THE MAT INDUSTRY 研究垫业工人常见的肌肉骨骼问题
Pub Date : 2024-04-01 DOI: 10.36106/ijsr/5704520
Tanvi Mahesh Patil, Rohan Mahesh Patil
Aim: - Methodology:- To study common musculoskeletal problems in Workers of the Mat Industry. A cross sectionalsurvey was conducted on 100 plastic industry workers by administering the Cornell Musculoskeletal DiscomfortQuestionnaire (CMDQ) to quantify the musculoskeletal pain. Additionally, a self-designed questionnaire was given out to gather data on thedifferent musculoskeletal issues that the employees experienced, risk factors associated with their jobs, different postures they maintained, anddaily activities they engaged in. A total of 100 participants were analysed in this study. Individua Results:- ls aged 20 to 30 appear to experiencediscomfort primarily in the knee (18.5%) and foot (19.2) areas, while those aged 31 to 40 report notable discomfort in the knee (24.5%) and foot(20.1%). In the 41 to 50 age group, lower back (19.3%) and knee (22.9%) discomfort are particularly prominent and awkward postures werehighly associated with musculoskeletal disorders. The most often affected body part was the knee, w Conclusion: - hich was followed by thelower back, foot, and shoulder. The majority of the workforce was expected to perform duties that frequently required bending and prolongedsitting, which has led to a high frequency of musculoskeletal problems associated with the workplace in this population. The research ndingsindicate that the adoption of ergonomic intervention strategies in the workplace has the potential to eradicate ergonomic risks and reduce thelikelihood of musculoskeletal illnesses associated with labour.
目的:- 方法:- 研究垫子行业工人常见的肌肉骨骼问题。对 100 名塑料行业工人进行了横断面调查,采用康奈尔肌肉骨骼不适感问卷(CMDQ)来量化肌肉骨骼疼痛。此外,还发放了一份自行设计的调查问卷,以收集有关员工所经历的不同肌肉骨骼问题、与工作相关的风险因素、所保持的不同姿势以及所从事的日常活动的数据。本研究共对 100 名参与者进行了分析。研究结果显示:20 至 30 岁年龄组的员工主要在膝部(18.5%)和足部(19.2%)感到不适,而 31 至 40 岁年龄组的员工则在膝部(24.5%)和足部(20.1%)感到明显不适。在 41 至 50 岁年龄组中,腰部(19.3%)和膝部(22.9%)的不适感尤为突出,姿势不正确与肌肉骨骼疾病有很大关系。最常受影响的身体部位是膝关节,其次是腰部、足部和肩部。大多数劳动力从事的工作经常需要弯腰和长时间坐着,这就导致了这一人群在工作场所出现肌肉骨骼问题的频率很高。研究 ndings 表明,在工作场所采用人体工程学干预策略有可能消除人体工程学风险,降低与劳动相关的肌肉骨骼疾病的发生率。
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引用次数: 0
期刊
Indian journal of applied research
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