The outbreak of respiratory illness caused by a novel corona virus (named “COVID-2019”) was declared a global health emergency on 30 January 2020 and a pandemic on 11 March 2020 by the World Health Organization (WHO) (1). The function of laboratory medicine emerged during infectious disease outbreaks eruption has a well-established history(4). Clinical chemistry laboratories played a vital role in treating the COVID-19 pandemic in several ways, by establishing diagnosis, prognosis, disease staging, therapeutic medication monitoring, and epidemiologic surveillance investigations (5).
{"title":"IMPACT OF COVID-19 ON INDIAN MEDICAL POSTGRADUATES FROM DIAGNOSTIC BRANCHES","authors":"Anuswaru Anuswaru, Sathyam Sathyam, Suvarna Kudiri, Madhavi Kondeti","doi":"10.36106/ijar/0200869","DOIUrl":"https://doi.org/10.36106/ijar/0200869","url":null,"abstract":"The outbreak of respiratory illness caused by a novel corona virus\u0000(named “COVID-2019”) was declared a global health emergency on 30\u0000January 2020 and a pandemic on 11 March 2020 by the World Health\u0000Organization (WHO) (1). The function of laboratory medicine emerged\u0000during infectious disease outbreaks eruption has a well-established\u0000history(4). Clinical chemistry laboratories played a vital role in treating\u0000the COVID-19 pandemic in several ways, by establishing diagnosis,\u0000prognosis, disease staging, therapeutic medication monitoring, and\u0000epidemiologic surveillance investigations (5).","PeriodicalId":13502,"journal":{"name":"Indian journal of applied research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140774555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nagendra Singh Bhadauria, Vinod Kumar, Neeraj Kumar, Amit Singh
Aims and objectives: To compare the results of ne needle aspiration cytology (FNAC) and Tru-cut biopsy in order to detect pathology in clinically suspicious palpable breast lumps in outpatient setting. Furthermore, to evaluate the diagnostic usefulness of further histopathological details obtained with tru-cut biopsy, and its effect on preoperative planning of surgical treatment. A total of 50 women who presented to surgery OPD from January 2023 to December 2023 with Material and methods: clinically suspicious palpable breast lump at tertiary care medical college hospital in central Rajasthan, India were included in this prospective study. After detailed history and physical examination, both FNAC and tru-cut biopsy were performed in an outpatient setting. The sensitivity of Results: F.N.A.C. was 95%, specicity was 100% and diagnostic accuracy was 96% while sensitivity of Trucut biopsy was 100%, specicity was 100% and diagnostic accuracy was 100%. Tru-cut biopsy is more accurate than FNAC. Tru-cut biopsy was abl Conclusion: e to give histological diagnosis and results correlated 100% with nal histopathology report, with further information about tumour type, grade, lymph vascular invasion, and receptors status. It also permitted the eventual use of preoperative adjuvant therapy.
{"title":"COMPARATIVE STUDY BETWEEN FNAC AND TRUCUT BIOPSY IN CLINICALLY SUSPICIOUS PALPABLE BREAST LESIONS.","authors":"Nagendra Singh Bhadauria, Vinod Kumar, Neeraj Kumar, Amit Singh","doi":"10.36106/ijar/8404904","DOIUrl":"https://doi.org/10.36106/ijar/8404904","url":null,"abstract":"Aims and objectives: To compare the results of ne needle aspiration cytology (FNAC) and Tru-cut biopsy in order to\u0000detect pathology in clinically suspicious palpable breast lumps in outpatient setting. Furthermore, to evaluate the\u0000diagnostic usefulness of further histopathological details obtained with tru-cut biopsy, and its effect on preoperative planning of surgical\u0000treatment. A total of 50 women who presented to surgery OPD from January 2023 to December 2023 with Material and methods: clinically\u0000suspicious palpable breast lump at tertiary care medical college hospital in central Rajasthan, India were included in this prospective study. After\u0000detailed history and physical examination, both FNAC and tru-cut biopsy were performed in an outpatient setting. The sensitivity of Results:\u0000F.N.A.C. was 95%, specicity was 100% and diagnostic accuracy was 96% while sensitivity of Trucut biopsy was 100%, specicity was 100%\u0000and diagnostic accuracy was 100%. Tru-cut biopsy is more accurate than FNAC. Tru-cut biopsy was abl Conclusion: e to give histological\u0000diagnosis and results correlated 100% with nal histopathology report, with further information about tumour type, grade, lymph vascular\u0000invasion, and receptors status. It also permitted the eventual use of preoperative adjuvant therapy.","PeriodicalId":13502,"journal":{"name":"Indian journal of applied research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140774537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Snake bite is one of the medical emergencies, most commonly reported from the developing countries of the Tropical region. Of this study is to estimate the burden of snake bite in Sheikh Bhikhari Medica Aim: l College and Hospital (SBMCH), Hazaribag and to assess the outcome of the admitted snakebite victims. This cross- Methodology: sectional study was conducted by collecting data from July 2022 to December 2022, from the records of Male medicine ward. A total of 342 male patients Results: recorded as snake bite victims. Mean (SD) age and duration of Hospital stay was 34.90(15.203) and 2.29(1.034) respectively. In majority (84.5%) of the Patients the outcome was good and were discharged after treatment. The study revealed maximum Conclusion: number of snake bite victims during Monsoon. The outcome of the admitted patients is good. Awareness campaign prior to monsoon focusing the preventive measures is needed to reduce the case load.
{"title":"BURDEN OF SNAKE BITE IN SHEIKH BHIKHARI MEDICAL COLLEGE AND HOSPITAL, HAZARIBAG: A SECONDARY DATA ANALYSIS","authors":"Soma Oraon, Anju Prabha Kumari, Manoj Kumar Purty","doi":"10.36106/ijar/1804706","DOIUrl":"https://doi.org/10.36106/ijar/1804706","url":null,"abstract":"Background: Snake bite is one of the medical emergencies, most commonly reported from the developing countries of\u0000the Tropical region. Of this study is to estimate the burden of snake bite in Sheikh Bhikhari Medica Aim: l College and\u0000Hospital (SBMCH), Hazaribag and to assess the outcome of the admitted snakebite victims. This cross- Methodology: sectional study was\u0000conducted by collecting data from July 2022 to December 2022, from the records of Male medicine ward. A total of 342 male patients Results:\u0000recorded as snake bite victims. Mean (SD) age and duration of Hospital stay was 34.90(15.203) and 2.29(1.034) respectively. In majority (84.5%)\u0000of the Patients the outcome was good and were discharged after treatment. The study revealed maximum Conclusion: number of snake bite\u0000victims during Monsoon. The outcome of the admitted patients is good. Awareness campaign prior to monsoon focusing the preventive measures\u0000is needed to reduce the case load.","PeriodicalId":13502,"journal":{"name":"Indian journal of applied research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140795791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Henoch-Schönlein purpura (HSP) is the most frequent leukocytoclastic systemic small-vessel vasculitis in children. HSP can present with a wide variety of clinical symptoms, from proteinuria and microscopic hematuria without any symptoms to variable degrees of acute kidney injury (AKI) and fast progressing glomerulonephritis with a high risk of long-term renal impairment. The kind and extent of organ involvement determines therapy options in more severe situations. A 12 year old Case Summary: female admitted to New Civil Hospital Surat with chief complaints of rash since 8 days. Also associated with joint and abdominal pain. Patient also gave history of cough, cold, sorethroat. Investigations done, Dermatologist opinion was taken for skin biopsy, skin biopsy showed leukocytoclastic vasculitis with IgA deposits. Patient Started on prednisolone 1mg/kg/day, Patient showed improvement with prednisolone within one week and was discharged sucessfully. It is crucial to dene the differential diagnosis w Discussion: ith other bullous diseases in childhood. Prognosis of HSP is good if there is no renal involvement. Henoch-Schönlein purpura is a Conclusion: frequent paediatric vasculitis that is multi-systemic. Although the prognosis is often quite good, some individuals may experience long-term effects, usually in the kidneys.
背景：过敏性紫癜（HSP）是儿童中最常见的白细胞破坏性全身性小血管炎。HSP 可表现出多种临床症状，从无任何症状的蛋白尿和镜下血尿，到不同程度的急性肾损伤（AKI）和进展迅速的肾小球肾炎，以及长期肾功能损害的高风险。器官受累的种类和程度决定了更严重情况下的治疗方案。病例摘要：女性，12 岁，主诉皮疹 8 天，入住苏拉特新民事医院。同时伴有关节和腹痛。患者也有咳嗽、感冒和喉咙痛病史。皮肤科医生建议患者进行皮肤活检，活检结果显示患者患有白细胞减少性血管炎，并伴有 IgA 沉积。患者开始服用泼尼松龙 1 毫克/千克/天，一周后病情有所好转并顺利出院。讨论：与其他牛皮癣的鉴别诊断至关重要。如果没有累及肾脏，HSP的预后良好。结论：HSP 是一种多系统的小儿血管炎。虽然预后通常很好，但有些人可能会受到长期影响，通常是肾脏。
{"title":"A CASE REPORT OF HENOCH-SCHÖNLEIN PURPURA","authors":"Raksha Kamat, Panna Bulsara","doi":"10.36106/ijar/9403368","DOIUrl":"https://doi.org/10.36106/ijar/9403368","url":null,"abstract":"Background: Henoch-Schönlein purpura (HSP) is the most frequent leukocytoclastic systemic small-vessel vasculitis in\u0000children. HSP can present with a wide variety of clinical symptoms, from proteinuria and microscopic hematuria without\u0000any symptoms to variable degrees of acute kidney injury (AKI) and fast progressing glomerulonephritis with a high risk of long-term renal\u0000impairment. The kind and extent of organ involvement determines therapy options in more severe situations. A 12 year old Case Summary:\u0000female admitted to New Civil Hospital Surat with chief complaints of rash since 8 days. Also associated with joint and abdominal pain. Patient\u0000also gave history of cough, cold, sorethroat. Investigations done, Dermatologist opinion was taken for skin biopsy, skin biopsy showed\u0000leukocytoclastic vasculitis with IgA deposits. Patient Started on prednisolone 1mg/kg/day, Patient showed improvement with prednisolone\u0000within one week and was discharged sucessfully. It is crucial to dene the differential diagnosis w Discussion: ith other bullous diseases in\u0000childhood. Prognosis of HSP is good if there is no renal involvement. Henoch-Schönlein purpura is a Conclusion: frequent paediatric vasculitis\u0000that is multi-systemic. Although the prognosis is often quite good, some individuals may experience long-term effects, usually in the kidneys.","PeriodicalId":13502,"journal":{"name":"Indian journal of applied research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140795528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dipanjan Goswami, Sheetal Upreti, Gaurav Saxena, S. Neogi, Simmi K Ratan
Rhabdomyoscarcoma of bladder in paediatric population is a rare tumour with guarded prognosis. Upfront surgery is indicated only in cases of possibility of complete resection followed by chemotherapy and radiotherapy. We present a case of rapidly progressing lump with imminent abdominal compartment syndrome, for which upfront resection was done to alleviate patient symptoms followed by chemotherapy and radiotherapy.
{"title":"RAPIDLY PROGRESSING PELVIC LUMP: WORKUP OR RESECTION TO PREVENT IMMINENT ABDOMINAL COMPARTMENT SYNDROME.","authors":"Dipanjan Goswami, Sheetal Upreti, Gaurav Saxena, S. Neogi, Simmi K Ratan","doi":"10.36106/ijar/5801653","DOIUrl":"https://doi.org/10.36106/ijar/5801653","url":null,"abstract":"Rhabdomyoscarcoma of bladder in paediatric population is a rare tumour with guarded prognosis. Upfront surgery is\u0000indicated only in cases of possibility of complete resection followed by chemotherapy and radiotherapy. We present a case\u0000of rapidly progressing lump with imminent abdominal compartment syndrome, for which upfront resection was done to alleviate patient\u0000symptoms followed by chemotherapy and radiotherapy.","PeriodicalId":13502,"journal":{"name":"Indian journal of applied research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140792118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tuberculosis is a major health concern in India with extra- pulmonary presentation being 66.6% in pregnancy . Spinal TB or Pott's Spine in pregnancy is a rare entity which can lead to paraplegia and adverse feto-maternal outcomes. Our patient presented at 34+4 weeks POG with bilateral lower limb weakness and backache since 28weeks period of gestation. Paraparesis being an uncommon complaint in pregnancy, has varied etiology which involves spinal cord. Common causes include traumatic fracture injury, spinal cord compression due to tumor, metastasis, spinal TB, Pyogenic abscess and Transverse myelitis, Polio, Guillain-Barré syndrome (GBS), amyotrophic lateral sclerosis and Syringomyelia being the less common. The history, neurological examination and imaging helps in narrowing the diagnosis. In Pott's Spine, lower thoracic and upper lumbar region are affected the most. WHO recommends 6 months of therapy with intensive phase of 2 months and continuation phase of 4 months which can be prolonged to 12 – 18 months based on symptoms and imaging. Pott's Spine with neurological decits or those who show progressive decit even on ATT needs surgery. MRI is ideal in such a condition and prognosis is good with early decompression surgery with ATT.
{"title":"POTT'S SPINE MANIFESTING AS PARAPLEGIA IN PREGNANCY AND ITS MANAGEMENT: A CASE REPORT","authors":"Ridham Ridham, Yamini Jassal, Mohit Satodiya","doi":"10.36106/ijar/9504129","DOIUrl":"https://doi.org/10.36106/ijar/9504129","url":null,"abstract":"Tuberculosis is a major health concern in India with extra- pulmonary presentation being 66.6% in pregnancy . Spinal TB\u0000or Pott's Spine in pregnancy is a rare entity which can lead to paraplegia and adverse feto-maternal outcomes. Our patient\u0000presented at 34+4 weeks POG with bilateral lower limb weakness and backache since 28weeks period of gestation. Paraparesis being an\u0000uncommon complaint in pregnancy, has varied etiology which involves spinal cord. Common causes include traumatic fracture injury, spinal cord\u0000compression due to tumor, metastasis, spinal TB, Pyogenic abscess and Transverse myelitis, Polio, Guillain-Barré syndrome (GBS), amyotrophic\u0000lateral sclerosis and Syringomyelia being the less common. The history, neurological examination and imaging helps in narrowing the diagnosis.\u0000In Pott's Spine, lower thoracic and upper lumbar region are affected the most. WHO recommends 6 months of therapy with intensive phase of 2\u0000months and continuation phase of 4 months which can be prolonged to 12 – 18 months based on symptoms and imaging. Pott's Spine with\u0000neurological decits or those who show progressive decit even on ATT needs surgery. MRI is ideal in such a condition and prognosis is good with\u0000early decompression surgery with ATT.","PeriodicalId":13502,"journal":{"name":"Indian journal of applied research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140790457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cancer is the leading cause of death in the world; and cancer treatments are becoming more expensive and there are not resources available in any institution or government for their cure. In 2020, there were 19.3 million new cases and around 10 million deaths and 28.4 million cases are expected by 2024. The most common types of cancer are breast, lung, colon and rectum and prostate; approximately 30% are due to tobacco use, alcohol consumption, low fruit and vegetable intake, and lack of physical activity; as well as infections caused by hepatitis viruses or human papillomaviruses. Cancer in children and adolescents is one of the leading causes of death in the worldwide. Each year, more than 400,000 children are diagnosed globally. In children, leukemias are more common, then brain tumors, and then lymphomas. This makes it a public health problem in Mexico and the worldwide. Amino acids stimulate cell growth and development cellular. Polyamines are the integrated part of the cellular and genetic metabolism and help in transcription, translocation, signaling and post-translational modications. Polyamines binding to RNA leads to structural changes which stimulate and increase the protein synthesis along the amino acids may inuence the conditions of various diseases. Several diseases can be controlled to a higher extend via maintaining the metabolism of amino acids and polyamines. On the other hand, a controlled diet is a way to maintain the level of amino acids and polyamines in the body. Present review highlights to etiology of cancer, also discusses functions and metabolism of polyamines in human and also highlights the nutritional role of amino acids and polyamines in the prevention and control of various diseases.
{"title":"CANCER: ETIOLOGY, CONTROL AND NUTRITION","authors":"Eliseo Ruiz Bedolla, Israel Parra Ortega","doi":"10.36106/ijar/8110477","DOIUrl":"https://doi.org/10.36106/ijar/8110477","url":null,"abstract":"Cancer is the leading cause of death in the world; and cancer treatments are becoming more expensive and there are not\u0000resources available in any institution or government for their cure. In 2020, there were 19.3 million new cases and around\u000010 million deaths and 28.4 million cases are expected by 2024. The most common types of cancer are breast, lung, colon and rectum and prostate;\u0000approximately 30% are due to tobacco use, alcohol consumption, low fruit and vegetable intake, and lack of physical activity; as well as\u0000infections caused by hepatitis viruses or human papillomaviruses. Cancer in children and adolescents is one of the leading causes of death in the\u0000worldwide. Each year, more than 400,000 children are diagnosed globally. In children, leukemias are more common, then brain tumors, and then\u0000lymphomas. This makes it a public health problem in Mexico and the worldwide. Amino acids stimulate cell growth and development cellular.\u0000Polyamines are the integrated part of the cellular and genetic metabolism and help in transcription, translocation, signaling and post-translational\u0000modications. Polyamines binding to RNA leads to structural changes which stimulate and increase the protein synthesis along the amino acids\u0000may inuence the conditions of various diseases. Several diseases can be controlled to a higher extend via maintaining the metabolism of amino\u0000acids and polyamines. On the other hand, a controlled diet is a way to maintain the level of amino acids and polyamines in the body. Present\u0000review highlights to etiology of cancer, also discusses functions and metabolism of polyamines in human and also highlights the nutritional role\u0000of amino acids and polyamines in the prevention and control of various diseases.","PeriodicalId":13502,"journal":{"name":"Indian journal of applied research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140755903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Essential oils so far have been investigated for their use in wound healing, treating respiratory disorders, antimicrobial and antioxidant properties. They are now looked upon as novel therapeutic agents to treat bacterial biolms. Interactions of four key components of essential oils of Hedychium coronarium J. Koenig, an endangered, medicinal and aromatic plant with matrix proteins viz., Self-associating proteins of Escherichia coli, with Lec B protein of Pseudomonas aeruginosa and Sortase protein of Staphylococcus aureus were studied through molecular docking and molecular dynamics. The key components of the essential oils selected were β-carotene, caryophyllene oxide, eucalyptol and sitosterol..All the four components showed good, stable interactions with Self-Associating Protein of Escherichia coli. β-carotene, eucalyptol and sitosterol interactions with Lec B protein of Pseudomonas aeruginosa were also stable with the exception of caryophyllene. In case of Staphylococcus aureus, with the exception of eucalyptol, promising results were seen with β-carotene, caryophyllene and sitosterol. The selected essential oil components showed good stable interactions with matrix proteins through in silico results thereby validating that natural remedies may be considered for treating fatal illnesses as well.
迄今为止，人们一直在研究精油在伤口愈合、治疗呼吸系统疾病、抗菌和抗氧化方面的用途。现在，它们被视为治疗细菌性生物lms 的新型治疗剂。通过分子对接和分子动力学研究了濒危药用芳香植物 Hedychium coronarium J. Koenig 的精油中的四种主要成分与基质蛋白（即大肠杆菌的自结合蛋白、绿脓杆菌的 Lec B 蛋白和金黄色葡萄球菌的 Sortase 蛋白）之间的相互作用。所选精油的主要成分为 β-胡萝卜素、氧化叶黄素、桉叶油醇和西托脂醇。这四种成分均与大肠杆菌的自相关蛋白（Self-Associating Protein of Escherichia coli）有良好、稳定的相互作用。就金黄色葡萄球菌而言，除桉叶油醇外，β-胡萝卜素、茶叶烯和西托脂醇都有良好的效果。所选的精油成分与基质蛋白的硅学结果显示出良好稳定的相互作用，从而验证了天然疗法也可用于治疗致命疾病。
{"title":"IN SILICO STUDIES OF THE INTERACTIONS OF KEY TERPENOIDS OF ESSENTIAL OILS OF HEDYCHIUM CORONARIUM J. KOENIG, AN ENDANGERED MEDICINAL AND AROMATIC PLANT WITH MATRIX PROTEINS OF BACTERIAL BIOFILMS","authors":"Kamath Vaishali, Suveena S, Dawda Himanshu","doi":"10.36106/ijar/9410017","DOIUrl":"https://doi.org/10.36106/ijar/9410017","url":null,"abstract":"Essential oils so far have been investigated for their use in wound healing, treating respiratory disorders, antimicrobial\u0000and antioxidant properties. They are now looked upon as novel therapeutic agents to treat bacterial biolms. Interactions\u0000of four key components of essential oils of Hedychium coronarium J. Koenig, an endangered, medicinal and aromatic plant with matrix proteins\u0000viz., Self-associating proteins of Escherichia coli, with Lec B protein of Pseudomonas aeruginosa and Sortase protein of Staphylococcus aureus\u0000were studied through molecular docking and molecular dynamics. The key components of the essential oils selected were β-carotene,\u0000caryophyllene oxide, eucalyptol and sitosterol..All the four components showed good, stable interactions with Self-Associating Protein of\u0000Escherichia coli. β-carotene, eucalyptol and sitosterol interactions with Lec B protein of Pseudomonas aeruginosa were also stable with the\u0000exception of caryophyllene. In case of Staphylococcus aureus, with the exception of eucalyptol, promising results were seen with β-carotene,\u0000caryophyllene and sitosterol. The selected essential oil components showed good stable interactions with matrix proteins through in silico results\u0000thereby validating that natural remedies may be considered for treating fatal illnesses as well.","PeriodicalId":13502,"journal":{"name":"Indian journal of applied research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140768219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Psychological distress is known to affect a person's overall mental well-being and college students are often seen as a bundle of energy. Therefore the present investigation studiesthe emotional distress and mental help seeking attitude among college going students in south Indian city. 94 college going students aged between 18 to 25 years pursuing degree course from colleges at Chennai, Tamil Nādu, India was enrolled in this study using random sampling method. After obtaining informed consent, DASS-21 and MHSAS were selfadministered to assess the level of Depression, Anxiety, Stress, and Mental Help Seeking Behaviour (MHSB). Psychological distress in the form of mild level of Depression and moderate level of Anxiety along with MHSB was present among the college students. There is a positive correlation between Depression, Anxiety, Stress, and MHSB (significant at p<0.01). Significant difference was observed between nuclear and joint family towards MHSB (t = 2.896, p < 0.01) and Domicile and MHSB (F=4.060, p<0.05) and between economic status and MHSB (F = 3.669, p<0.05). The ndings of the current study concluded the presence of Depression and Anxiety features among college students and thus there is a need for periodic mental health assessment of college going students and subsequent addressal of their mental health issues, if there is need.
众所周知，心理困扰会影响一个人的整体心理健康，而大学生往往被视为精力充沛。因此，本调查研究了印度南部城市在校大学生的情绪困扰和心理求助态度。本研究采用随机抽样的方法，从印度泰米尔纳德邦金奈市的高校中选取了 94 名年龄在 18 至 25 岁之间、正在攻读学位课程的大学生。在获得知情同意后，对 DASS-21 和 MHSAS 进行了自我管理，以评估抑郁、焦虑、压力和心理求助行为（MHSB）的水平。结果表明，大学生中存在轻度抑郁和中度焦虑的心理困扰以及心理求助行为（MHSB）。抑郁、焦虑、压力和 MHSB 之间呈正相关（p<0.01 为显著）。在核心家庭和联合家庭与 MHSB 之间（t=2.896，p<0.01）、户籍与 MHSB 之间（F=4.060，p<0.05）以及经济状况与 MHSB 之间（F=3.669，p<0.05）存在显著差异。ndings of the current study concluded the presence of Depression and Anxiety features among college students and thus there is an need for periodic mental health assessment of college going students and subsequent addressal of their mental health issues, if there is need.
{"title":"PSYCHOLOGICAL DISTRESS AND MENTAL HELP SEEKING BEHAVIOR AMONG THE COLLEGE STUDENTS","authors":"Kalaivani. P, Laxmi Narayan Rathore","doi":"10.36106/ijar/2602054","DOIUrl":"https://doi.org/10.36106/ijar/2602054","url":null,"abstract":"Psychological distress is known to affect a person's overall mental well-being and college students are often seen as a bundle\u0000of energy. Therefore the present investigation studiesthe emotional distress and mental help seeking attitude among college\u0000going students in south Indian city. 94 college going students aged between 18 to 25 years pursuing degree course from colleges at Chennai, Tamil\u0000Nādu, India was enrolled in this study using random sampling method. After obtaining informed consent, DASS-21 and MHSAS were selfadministered to assess the level of Depression, Anxiety, Stress, and Mental Help Seeking Behaviour (MHSB). Psychological distress in the form of\u0000mild level of Depression and moderate level of Anxiety along with MHSB was present among the college students. There is a positive\u0000correlation between Depression, Anxiety, Stress, and MHSB (significant at p<0.01). Significant difference was observed between nuclear and\u0000joint family towards MHSB (t = 2.896, p < 0.01) and Domicile and MHSB (F=4.060, p<0.05) and between economic status and MHSB (F = 3.669,\u0000p<0.05). The ndings of the current study concluded the presence of Depression and Anxiety features among college students and thus there is a need\u0000for periodic mental health assessment of college going students and subsequent addressal of their mental health issues, if there is need.","PeriodicalId":13502,"journal":{"name":"Indian journal of applied research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140757173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Gallbladder carcinoma (CA) is the most common primary biliary carcinoma and fth most common malignancy of the gastrointestinal tract. Incidence of gall bladder carcinoma is highest in Asian countries and this had increased recently due to improved detection rates. Approximately 90% of Gall Bladder cancers have accompanying cholelithiasis. Adenocarcinoma is the most common histologic type, accounting for 98% of all gallbladder tumors with almost a third of cases presenting with distant metastasis. 1.To study various features of CT in GB masses. 2.To detect the sensitivity, spe Objectives: cicity, positive predictive value and negative predictive value of CT in diagnosing gall bladder masses by comparing with ndings ne-needle aspiration cytology (FNAC) and histopathological examination. Materials and Method: Total 50 patients are included in this study who have presented to Surgery OPD, Agartala government medical college and GBP hospital with symptoms related to GB masses. All the patients subsequently undergo MDCT and subsequently CT guided FNAC for cytological correlation and followed up to post operative histopathological examination Results: In our study, age of the GB mass patients was ranged from 30 to 90 years. Maximum number of patients were in the age group between 51 and 60 years, about 29%, and age group between 61 and 70 years, about 27%. Minimum number of patients were in the group between -30-40 years and 81–90 years. The average age of the patients presented was 58 years. Of 50 patients of the GB masses, 65% were detected in females and 35% were detected in males. Female predominance is seen. Conclusion: The overall mean age of the patients presented was 58 year, and the overall female-to-male ratio was 1.9:1. The most common presenting symptom was jaundice which was seen in 87% of cases. In our study, overall detection of GB carcinoma CT could detect 93% of cases same as FNAC detection of GB carcinoma.
{"title":"VALIDITY OF COMPUTED TOMOGRAPHY IN DIAGNOSING GALLBLADDER MASSES AND THEIR CORRELATION WITH FINENEEDLE ASPIRATION CYTOLOGY AND HISTOPATHOLOGICAL EXAMINATION IN A TEACHING HOSPITAL IN NORTH-EAST INDIA.","authors":"Nahid Niaj, P. Santoshi","doi":"10.36106/ijar/5302620","DOIUrl":"https://doi.org/10.36106/ijar/5302620","url":null,"abstract":"Introduction: Gallbladder carcinoma (CA) is the most common primary biliary carcinoma and fth most common\u0000malignancy of the gastrointestinal tract. Incidence of gall bladder carcinoma is highest in Asian countries and this had\u0000increased recently due to improved detection rates. Approximately 90% of Gall Bladder cancers have accompanying cholelithiasis.\u0000Adenocarcinoma is the most common histologic type, accounting for 98% of all gallbladder tumors with almost a third of cases presenting with\u0000distant metastasis. 1.To study various features of CT in GB masses. 2.To detect the sensitivity, spe Objectives: cicity, positive predictive value\u0000and negative predictive value of CT in diagnosing gall bladder masses by comparing with ndings ne-needle aspiration cytology (FNAC) and\u0000histopathological examination. Materials and Method: Total 50 patients are included in this study who have presented to Surgery OPD,\u0000Agartala government medical college and GBP hospital with symptoms related to GB masses. All the patients subsequently undergo MDCT and\u0000subsequently CT guided FNAC for cytological correlation and followed up to post operative histopathological examination Results: In our\u0000study, age of the GB mass patients was ranged from 30 to 90 years. Maximum number of patients were in the age group between 51 and 60 years,\u0000about 29%, and age group between 61 and 70 years, about 27%. Minimum number of patients were in the group between -30-40 years and 81–90\u0000years. The average age of the patients presented was 58 years. Of 50 patients of the GB masses, 65% were detected in females and 35% were\u0000detected in males. Female predominance is seen. Conclusion: The overall mean age of the patients presented was 58 year, and the overall\u0000female-to-male ratio was 1.9:1. The most common presenting symptom was jaundice which was seen in 87% of cases. In our study, overall\u0000detection of GB carcinoma CT could detect 93% of cases same as FNAC detection of GB carcinoma.","PeriodicalId":13502,"journal":{"name":"Indian journal of applied research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140780589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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