Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3403
Pradip K Kumbharwad, Somya Singh, Indrajeet S Gadge, Shrikant A Dighe
Bhallataka (Semicarpus Anacaardium Linn. Anacardiaceae) is mentioned as a poisonous medical plant under drug and cosmetic act 1940. Local application of Bhallataka is more common as many people use Bhallataka as home remedy for relieving pain. Bhallataka oil is used commercially in industry for preparation of dyes etc. So, exposure to oil and contact poisoning of Bhallataka is quite common in India. According to Yogaratnakara, Shala Patra Churna, internally & externally application on the whole body immediately relieves the poisonous effect of Bhallataka. Aim: To study efficacy of Shala Patra Churna in contact poisoning due to Bhallataka Taila in Albino mice. Objective: To study antitoxic properties of Shala Patra Churna in contact poisoning due to Bhallataka Taila. Material and methods: Preparation, authentication, and standardization of Bhallatak Tail and Shala Patra Churna. 3 groups were made each of 6 mice. After application procedure, all mice were observed for 24 hours for any signs. Rating of skin reaction was evaluated as per the Indian Standard BIS (Bureau of Indian Standards )1992. Test sample and standard drug applied for 7 consecutive days. Observation and results: Observation done in 3 groups of animals for the duration of 7 days study. All the necessary precautions were taken to carry out each step during study. Conclusion: Effect of local application of Shala patra churna is equivalent to the standard drug (silver nitrate gel). Therefore, Shala plant can be significantly used for the treatment of Bhallataka induced contact poison.
{"title":"An experimental study of efficacy of Shala patra churna in contact poisoning due to Bhallataka taila in albino mice","authors":"Pradip K Kumbharwad, Somya Singh, Indrajeet S Gadge, Shrikant A Dighe","doi":"10.47552/ijam.v14i2.3403","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3403","url":null,"abstract":"Bhallataka (Semicarpus Anacaardium Linn. Anacardiaceae) is mentioned as a poisonous medical plant under drug and cosmetic act 1940. Local application of Bhallataka is more common as many people use Bhallataka as home remedy for relieving pain. Bhallataka oil is used commercially in industry for preparation of dyes etc. So, exposure to oil and contact poisoning of Bhallataka is quite common in India. According to Yogaratnakara, Shala Patra Churna, internally & externally application on the whole body immediately relieves the poisonous effect of Bhallataka. Aim: To study efficacy of Shala Patra Churna in contact poisoning due to Bhallataka Taila in Albino mice. Objective: To study antitoxic properties of Shala Patra Churna in contact poisoning due to Bhallataka Taila. Material and methods: Preparation, authentication, and standardization of Bhallatak Tail and Shala Patra Churna. 3 groups were made each of 6 mice. After application procedure, all mice were observed for 24 hours for any signs. Rating of skin reaction was evaluated as per the Indian Standard BIS (Bureau of Indian Standards )1992. Test sample and standard drug applied for 7 consecutive days. Observation and results: Observation done in 3 groups of animals for the duration of 7 days study. All the necessary precautions were taken to carry out each step during study. Conclusion: Effect of local application of Shala patra churna is equivalent to the standard drug (silver nitrate gel). Therefore, Shala plant can be significantly used for the treatment of Bhallataka induced contact poison. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48488659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3641
Bharathy K, Dhivya G, Lakshmi Kantham T, M. R
Background: Siddha Medicine is emerging as the treatment of choice for various diseases. Hypertension is one among the comorbidities which plays a major role leading to stroke, cardiovascular diseases and renal failure. Objective: To perform the In Silico computational studies of phytocomponents of Imbural vadagam and to evaluate its anti-hypertensive potential. Methods: Auto dock program was used for the molecular docking studies against Angiotensin Converting Enzyme(ACE). Results: Asperulosidic acid, 6α-Hydroxygeniposide, Piperic acid, Piperine, Apigenin, Orientin and Vitexin that exist in the siddha drug Imbural vadagam exhibit remarkable binding against the target Angiotensin converting enzyme. Conclusion: It can be that these phytocomponents exhibit remarkable antihypertensive activity.
{"title":"Anti-hypertensive effect of Siddha formulation Imbural Vadagam against Human angiotensin converting enzyme using In-Silico model","authors":"Bharathy K, Dhivya G, Lakshmi Kantham T, M. R","doi":"10.47552/ijam.v14i2.3641","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3641","url":null,"abstract":"Background: Siddha Medicine is emerging as the treatment of choice for various diseases. Hypertension is one among the comorbidities which plays a major role leading to stroke, cardiovascular diseases and renal failure. Objective: To perform the In Silico computational studies of phytocomponents of Imbural vadagam and to evaluate its anti-hypertensive potential. Methods: Auto dock program was used for the molecular docking studies against Angiotensin Converting Enzyme(ACE). Results: Asperulosidic acid, 6α-Hydroxygeniposide, Piperic acid, Piperine, Apigenin, Orientin and Vitexin that exist in the siddha drug Imbural vadagam exhibit remarkable binding against the target Angiotensin converting enzyme. Conclusion: It can be that these phytocomponents exhibit remarkable antihypertensive activity. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44614740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3545
Sreelakshmi C L, S. Pani, V. B, S. Raskar
Ayurveda is an ancient medical practise that focuses on the prevention of illness and the treatment of conditions that are related to the human body. Ayurveda provides information on a wide variety of herbal remedies that can be used to cure a variety of disorders. In such a scenario, standardisation is necessary for ensuring uniformity from one batch of drug production to the next and for carrying out routine drug manufacturing on a large scale. In this age of shifting lifestyles and increased public interest, the process of modifying older dosage forms and the development of new dosage forms is an ever-evolving process that makes a significant contribution to the expansion and development of scientific knowledge. Granules are produced from a refined form of Ghana, which is a solid preparation of herbal extract, and Khanda Kalpana, which are solid preparations that are comparable to granules. Because it contains medications that are medhya, Smrutisudha granules are developed for their beneficial benefits, such as boosting children's memories. In the current work, standardisation, physio-chemical properties, qualitative analysis, and chromatography (HPTLC) of Smrutisudha granules have been produced. Prior to its application in therapeutic settings, the standardisation of Smrutisudha granules will be aided by this research.
{"title":"A Physico-chemical assay of a herbal formulation - Smrutisudha granules","authors":"Sreelakshmi C L, S. Pani, V. B, S. Raskar","doi":"10.47552/ijam.v14i2.3545","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3545","url":null,"abstract":"Ayurveda is an ancient medical practise that focuses on the prevention of illness and the treatment of conditions that are related to the human body. Ayurveda provides information on a wide variety of herbal remedies that can be used to cure a variety of disorders. In such a scenario, standardisation is necessary for ensuring uniformity from one batch of drug production to the next and for carrying out routine drug manufacturing on a large scale. In this age of shifting lifestyles and increased public interest, the process of modifying older dosage forms and the development of new dosage forms is an ever-evolving process that makes a significant contribution to the expansion and development of scientific knowledge. Granules are produced from a refined form of Ghana, which is a solid preparation of herbal extract, and Khanda Kalpana, which are solid preparations that are comparable to granules. Because it contains medications that are medhya, Smrutisudha granules are developed for their beneficial benefits, such as boosting children's memories. In the current work, standardisation, physio-chemical properties, qualitative analysis, and chromatography (HPTLC) of Smrutisudha granules have been produced. Prior to its application in therapeutic settings, the standardisation of Smrutisudha granules will be aided by this research. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43964759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.2950
Shweta B Maske, S. Rathod, A. Kolte, P. Bawankar, Madhur Gupta, Supriya Kaule
Background: Various locally delivered agent are used as an adjunct to scaling and root planning (SRP). 8- Hydroxydeoxyguanosine (8-OHdG) is best documented biomarker of oxidative stress in periodontitis. Objective: To evaluate the efficacy of locally delivered Ocimum sanctum gel by assessing the levels of 8-OHdG in Gingival crevicular fluid (GCF) of smokers and nonsmokers with periodontitis. Material and Methods: The study included 50 patients divided into 3 groups, group I - periodontally healthy, group II- smokers with stage II periodontitis and group III- non-smokers with stage II periodontitis. Smokers and non-smokers with stage II periodontitis received the locally delivered 10% OS gel as an adjunct to SRP at the test site at baseline and after 1 week recall, while SRP alone at control site. Result: 8-OHdG GCF levels were analyzed with enzyme-linked immunosorbent assay (ELISA) at baseline, and 6-months follow up. Probing pocket depth (PPD) in test site significantly reduced to 2.75 ±0.64, 2.50 ±0.68 at 6 month after periodontal therapy in group 2 and 3 respectively. Similarly, clinical attachment level (CAL) in test site significantly reduced to 3.15 ±0.81, 2.85 ±0.93 at 6 month after periodontal therapy in group 2 and 3 respectively. Conclusion: The application of 10% Ocimum sanctum L. gel showed significant improvement in PPD, CAL and PI and GI and reduction in GCF 8-OHdG levels.
{"title":"Evaluation of efficacy of locally delivered Herbal extract in treatment of Chronic periodontitis –A Randomised controlled trial","authors":"Shweta B Maske, S. Rathod, A. Kolte, P. Bawankar, Madhur Gupta, Supriya Kaule","doi":"10.47552/ijam.v14i2.2950","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.2950","url":null,"abstract":"Background: Various locally delivered agent are used as an adjunct to scaling and root planning (SRP). 8- Hydroxydeoxyguanosine (8-OHdG) is best documented biomarker of oxidative stress in periodontitis. Objective: To evaluate the efficacy of locally delivered Ocimum sanctum gel by assessing the levels of 8-OHdG in Gingival crevicular fluid (GCF) of smokers and nonsmokers with periodontitis. Material and Methods: The study included 50 patients divided into 3 groups, group I - periodontally healthy, group II- smokers with stage II periodontitis and group III- non-smokers with stage II periodontitis. Smokers and non-smokers with stage II periodontitis received the locally delivered 10% OS gel as an adjunct to SRP at the test site at baseline and after 1 week recall, while SRP alone at control site. Result: 8-OHdG GCF levels were analyzed with enzyme-linked immunosorbent assay (ELISA) at baseline, and 6-months follow up. Probing pocket depth (PPD) in test site significantly reduced to 2.75 ±0.64, 2.50 ±0.68 at 6 month after periodontal therapy in group 2 and 3 respectively. Similarly, clinical attachment level (CAL) in test site significantly reduced to 3.15 ±0.81, 2.85 ±0.93 at 6 month after periodontal therapy in group 2 and 3 respectively. Conclusion: The application of 10% Ocimum sanctum L. gel showed significant improvement in PPD, CAL and PI and GI and reduction in GCF 8-OHdG levels.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43662780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3459
J. L, S. S, Christian C J, Sugin Lal Jabaris S, Kabilan N, K. K
Aim and Objectives: Rheumatoid arthritis is an auto immune disease and its signs and symptoms are correlated with Uthira vatha Suronitham (UVS) in Siddha. Here we discussed a case series of Rheumatoid arthritis managed by a novel, classical Siddha formulation Amirdha Gandhi Kukkil Vallathy (AGKV). Methods: Three cases were diagnosed as Rheumatoid arthritis (RA) based on ACR/EULAR 2010 criteria, along with symptoms of UVS as per Siddha literature. All the three cases were treated with Siddha medicine AGKV 2 gm bid for 48 days in the General out patients department, Siddha Central Research Institute. Observations: The assessment was made by the signs and symptoms and serological parameters like C-Reactive protein (CRP), Erythrocyte Sedimentation Rate (ESR), Haemoglobin (Hb), Rheumatoid Arthritis factor (RA factor). Results: The RA Factor was reduced in all three patients from 60 to 13.9, from 133 to 106, from 60.7 IU/ml to 35.6 IU/ml ; CRP reduced in case 1 from 135.8 to 34.3, case 3 from 18.9 to 5.6, reduction in RAPS score and clinical symptoms were noticed in all three cases and were followed for 1 year and managed with diet advice. This case series highlights that RA can be successfully managed with Siddha herbo mineral preparation AGKV within a minimum period of 48 days. Hence in a long duration of treatment, it will certainly give good results to reduce the burden of RA patients.
{"title":"Management of Uthiravathasuronitham (Rheumatoid arthritis) by Siddha traditional formulation Amirdha Gandhi Kukkil Vallathy – A case series","authors":"J. L, S. S, Christian C J, Sugin Lal Jabaris S, Kabilan N, K. K","doi":"10.47552/ijam.v14i2.3459","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3459","url":null,"abstract":"Aim and Objectives: Rheumatoid arthritis is an auto immune disease and its signs and symptoms are correlated with Uthira vatha Suronitham (UVS) in Siddha. Here we discussed a case series of Rheumatoid arthritis managed by a novel, classical Siddha formulation Amirdha Gandhi Kukkil Vallathy (AGKV). Methods: Three cases were diagnosed as Rheumatoid arthritis (RA) based on ACR/EULAR 2010 criteria, along with symptoms of UVS as per Siddha literature. All the three cases were treated with Siddha medicine AGKV 2 gm bid for 48 days in the General out patients department, Siddha Central Research Institute. Observations: The assessment was made by the signs and symptoms and serological parameters like C-Reactive protein (CRP), Erythrocyte Sedimentation Rate (ESR), Haemoglobin (Hb), Rheumatoid Arthritis factor (RA factor). Results: The RA Factor was reduced in all three patients from 60 to 13.9, from 133 to 106, from 60.7 IU/ml to 35.6 IU/ml ; CRP reduced in case 1 from 135.8 to 34.3, case 3 from 18.9 to 5.6, reduction in RAPS score and clinical symptoms were noticed in all three cases and were followed for 1 year and managed with diet advice. This case series highlights that RA can be successfully managed with Siddha herbo mineral preparation AGKV within a minimum period of 48 days. Hence in a long duration of treatment, it will certainly give good results to reduce the burden of RA patients.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45875579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3609
J. Gupta, Archana S kukade, Sanjay Chandrakant Babar, Prathamesh Pradeep Kashikar
The lymphatic system has historically been disregarded, undervalued, and poorly understood. As it mimics chronic venous insufficiency, it leaves patients in a terrible condition. One such congenital condition where aberrant protein-rich fluid accumulates in the lower extremities is lymphedema praecox. In ‘Ayurvedic samhitas, there is a condition called Urustambha which can be correlated with Lymphedema praecox. Clinical characteristics and therapy are beautifully detailed in samhitas like Charak and Sushrut thousands of years ago, and modern science is leveraging them even today. Since this condition is uncommon, we decided to address and take up this case. A 25years old female was admitted in our opd with complaints of B/L lower limbs, huge swelling followed by long standing and feeling of heaviness. We diagnosed and treated the patient according to classical texts of Charak and Sushrut with baluka swedan, prachana karma, udwartan and few oral medications and got promising results. With ayurvedic intervention, their quality of life has been improved and no further medication was required.
{"title":"Lymphedema Praecox a subtle exigent case study through endogenic avenue W.S.R. to Urustambha","authors":"J. Gupta, Archana S kukade, Sanjay Chandrakant Babar, Prathamesh Pradeep Kashikar","doi":"10.47552/ijam.v14i2.3609","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3609","url":null,"abstract":"The lymphatic system has historically been disregarded, undervalued, and poorly understood. As it mimics chronic venous insufficiency, it leaves patients in a terrible condition. One such congenital condition where aberrant protein-rich fluid accumulates in the lower extremities is lymphedema praecox. In ‘Ayurvedic samhitas, there is a condition called Urustambha which can be correlated with Lymphedema praecox. Clinical characteristics and therapy are beautifully detailed in samhitas like Charak and Sushrut thousands of years ago, and modern science is leveraging them even today. Since this condition is uncommon, we decided to address and take up this case. A 25years old female was admitted in our opd with complaints of B/L lower limbs, huge swelling followed by long standing and feeling of heaviness. We diagnosed and treated the patient according to classical texts of Charak and Sushrut with baluka swedan, prachana karma, udwartan and few oral medications and got promising results. With ayurvedic intervention, their quality of life has been improved and no further medication was required. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44338750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3500
Harsha Gambhire Bhadugale, Umesh Tekawade, Suvarna P. Shelar, Suhas Herlekar
Background: According to Ayurveda, Ambu is one of the four essential factors of Garbhasambhav Samugri for formation and development of the embryo. The word Ambu means nutrients essential for formation and growth of embryo which it receives from mother. According to modern science, during implantation, embryo receives its nutrients from endometrium. Though some women have normal endometrial thickness, normal endometrial pattern, normal endometrial morphology, still they are unable to get impregnated. During peri-implantation period of menstrual cycle, endometrial vascularity has major role in implantation of fertilised egg and also further growth of foetus. Objectives: The objective of this study is to evaluate implantation rates in women having endometrial vascularity upto V1, V2, V3, V4 zones. Material & Methods: Anonymous data of endometrial vascularity by transvaginal colour doppler ultrasound examination done, on the day of rupture of follicle of menstrual cycle, on 160 women, willing to conceive, has been collected from gynaecologist. And also, her status whether she was implanted or not implanted was collected from the gynaecologist. Data about her pregnancy status upto 20 weeks were collected. From this collected data, results regarding endometrial vascularity were derived. Results: Implantation rate in cases having vascularity upto V1 zone, upto V2 zone, upto V3 zone, upto V4 zone were 0 %, 8.33 %, 25 %, 30.5% respectively. Conclusion: Implantation rate is greater in cases having vascularity upto V3 and V4 zone than V1 & V2 zone. Endometrial vascularity is an important factor for implantation of fertilized egg and also for further growth of embryo.
{"title":"An observational study of endometrial vascularity in implantation","authors":"Harsha Gambhire Bhadugale, Umesh Tekawade, Suvarna P. Shelar, Suhas Herlekar","doi":"10.47552/ijam.v14i2.3500","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3500","url":null,"abstract":"Background: According to Ayurveda, Ambu is one of the four essential factors of Garbhasambhav Samugri for formation and development of the embryo. The word Ambu means nutrients essential for formation and growth of embryo which it receives from mother. According to modern science, during implantation, embryo receives its nutrients from endometrium. Though some women have normal endometrial thickness, normal endometrial pattern, normal endometrial morphology, still they are unable to get impregnated. During peri-implantation period of menstrual cycle, endometrial vascularity has major role in implantation of fertilised egg and also further growth of foetus. Objectives: The objective of this study is to evaluate implantation rates in women having endometrial vascularity upto V1, V2, V3, V4 zones. Material & Methods: Anonymous data of endometrial vascularity by transvaginal colour doppler ultrasound examination done, on the day of rupture of follicle of menstrual cycle, on 160 women, willing to conceive, has been collected from gynaecologist. And also, her status whether she was implanted or not implanted was collected from the gynaecologist. Data about her pregnancy status upto 20 weeks were collected. From this collected data, results regarding endometrial vascularity were derived. Results: Implantation rate in cases having vascularity upto V1 zone, upto V2 zone, upto V3 zone, upto V4 zone were 0 %, 8.33 %, 25 %, 30.5% respectively. Conclusion: Implantation rate is greater in cases having vascularity upto V3 and V4 zone than V1 & V2 zone. Endometrial vascularity is an important factor for implantation of fertilized egg and also for further growth of embryo. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41920256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3640
Rishi Kumar, R. Mazumder, Amrish Chandra
Aims: The current study aimed to evaluate the genotoxicity of the Vaishvanara Churna, a polyherbal formulation by using Peripheral Blood Mononuclear Cells. The study was supported by the study of the content of heavy metals in the ayurvedic formulation. Background: Vaishvanara Churna is a classical ayurvedic formulation that is used for treating conditions, such as flatulence with gurgling sound (Adhmana), abdominal lump (Gulma); Duodenal ulcer (Parinamasula), Rheumatism (Amavata); heart disease (Hrdroga). Objective: The objective is to study the genotoxicity of Vaishvanara Churna on Peripheral Blood Mononuclear Cells using alkaline Single-cell Gel Electrophoresis and correlate the possible association of genotoxicity to the number of heavy metals present in the polyherbal formulation. Methodology: The Alkaline Single Cell Gel Electrophoresis was used to see the effects on the Peripheral Blood Mononuclear cells using 2% Hydrogen Peroxide as a standard oxidizing agent. Observation: Peripheral Blood Mononuclear Cells, isolated from a fresh human blood sample, were treated in vitro with varying concentrations of Vaishvanara Churna (0.2, 0.4, 0.8, 1.6, and 3.2 mg/ml of aqueous extract) using a standard protocol. It was found that none of the assessed concentrations of the ayurvedic formulation was toxic to Peripheral Blood Mononuclear Cells. Conclusion: Single-cell Gel Electrophoresis is a simple technique to evaluate the genotoxicity of any drug to Human Beings, and it can be used as an alternative to animal genotoxicity studies.
{"title":"Genotoxicity Evaluation of Vaishvanara Churna - A classical Ayurvedic Formulation","authors":"Rishi Kumar, R. Mazumder, Amrish Chandra","doi":"10.47552/ijam.v14i2.3640","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3640","url":null,"abstract":"Aims: The current study aimed to evaluate the genotoxicity of the Vaishvanara Churna, a polyherbal formulation by using Peripheral Blood Mononuclear Cells. The study was supported by the study of the content of heavy metals in the ayurvedic formulation. Background: Vaishvanara Churna is a classical ayurvedic formulation that is used for treating conditions, such as flatulence with gurgling sound (Adhmana), abdominal lump (Gulma); Duodenal ulcer (Parinamasula), Rheumatism (Amavata); heart disease (Hrdroga). Objective: The objective is to study the genotoxicity of Vaishvanara Churna on Peripheral Blood Mononuclear Cells using alkaline Single-cell Gel Electrophoresis and correlate the possible association of genotoxicity to the number of heavy metals present in the polyherbal formulation. Methodology: The Alkaline Single Cell Gel Electrophoresis was used to see the effects on the Peripheral Blood Mononuclear cells using 2% Hydrogen Peroxide as a standard oxidizing agent. Observation: Peripheral Blood Mononuclear Cells, isolated from a fresh human blood sample, were treated in vitro with varying concentrations of Vaishvanara Churna (0.2, 0.4, 0.8, 1.6, and 3.2 mg/ml of aqueous extract) using a standard protocol. It was found that none of the assessed concentrations of the ayurvedic formulation was toxic to Peripheral Blood Mononuclear Cells. Conclusion: Single-cell Gel Electrophoresis is a simple technique to evaluate the genotoxicity of any drug to Human Beings, and it can be used as an alternative to animal genotoxicity studies.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45181907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3302
Pallavi N Mane, Digambar Dg, Pruthviraj P Ugale, Abhijit Shekhar, Jibi Varghese, Anupama M Bathe, Abhilasha C. Lagad
Prameha (Diabetes mellitus) is an age long disease known from vedic period and now it is a leading lifestyle disorder. Diabetes mellitus is a group of metabolic syndromes of fat, protein and carbohydrate which is due to absolute or relative deficiency of insulin, characterized by hyperglycemia over a prolonged period with polyuria, polydipsia, and polyphagia like symptoms. The estimates in 2019 showed that 77 million individuals had diabetes in India, which is expected to rise to over 134 million by 2045. It has turned out to be the biggest “silent killer” in today’s world. This is an Open label Comparative clinical study with pre-test and post-test design where in 60 patients suffering from Prameha (type 2 DM) of either gender between the age group of 25 to 75 years were randomly selected and grouped into Group A and Group B. The 30 patients in Group A were treated with Arogyavardhini vati & Madhusudhan vati with Metformin (500 mg) and Glimepiride (1mg) BD. Group B of 30 patients were given Metformin (500mg) and Glimepiride (1 mg) for 120 days. Results obtained in subjective and objective parameters were analyzed for the statistical significance by adapting paired T test, unpaired T test, Mann-Whitney Z and Wilcoxon Signed Ranks Test Z. The study revealed that Group A was found to be more effective in bringing symptomatic relief and improving biochemical markers in the patients of Prameha.
Prameha（糖尿病）是一种从妊娠期开始就被认为是一种长期疾病，现在它是一种主要的生活方式障碍。糖尿病是一组由胰岛素绝对或相对缺乏引起的脂肪、蛋白质和碳水化合物代谢综合征，其特征是长期高血糖，伴有多尿、多饮和多食样症状。2019年的估计显示，印度有7700万人患有糖尿病，预计到2045年将增至1.34亿人以上。事实证明，它是当今世界最大的“无声杀手”。这是一项开放标签比较临床研究，采用试验前和试验后设计，随机选择60名年龄在25至75岁之间的Prameha（2型糖尿病）患者，分为A组和B组。A组的30名患者接受Arogyavardhini vati和Madhusudhan vati加二甲双胍（500 mg）和格列美脲（1mg）BD的治疗。B组30名患者服用二甲双胍（500mg）和格列美脲（1mg），持续120天。通过采用配对T检验、非配对T检验，Mann-Whitney Z和Wilcoxon Signed Ranks检验Z，分析主观和客观参数的结果的统计学意义。研究表明，A组在Prameha患者的症状缓解和改善生化标志物方面更有效。
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Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3405
A. Madgundi, C. Nitin, M. Chaudhari, Yogita Chaudhari
Today, interest in medicinal plants has increased dramatically. The description of these plants in ancient texts is very detailed, but in scattered form. We only discovered a few details in the Nighantus (an ancient pharmacopeia about medicinal plants). One should go through all available Ayurvedic texts for information on any medicinal plant. Amaltas (Cassia fistula linn.) has been popular since ancient times as a frequent remedy of choice for Ayurvedic physicians due to its various therapeutic properties. These properties are laxative, antibacterial, antipyretic, anti-inflammatory, smooth muscle stimulating, hepato-protective, analgesic, hypoglycaemic, anticancer, abortifacient, anti-colic, anti-infertility, oestrogens, etc. useful in the treatment of diseases such as skin diseases, heart problems, gout, blood diseases, diabetes mellitus, herpes, feverish conditions, etc. It grows in Indian habitat abundantly, and deciduous woodlands of south India. Its concentrate mostly contains alkaloids, tars, flavonoids, rhein glucoside, fisulic corrosive. It also possesses the properties such as hypo-glycemic, laxative, anti-bacterial, antipyretic, anti-inflammatory, smooth muscle stimulant, hepato-protective, analgesic, anticancer, abortifacient, anti-colic, antifertility, estrogenic, etc. It has vast therapeutic importance, but not enough addressed by Ayurvedic point of view, even though many therapeutic potential references from classical Ayurvedic texts are available. Hence, an attempt was made to review its therapeutic potential through this article, which will guide the researchers and scholars for further study. The focus of the current review is on the literature review and the analysis of the medicinal, nutritional utility and pharmacological effects of Amaltas.
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