Pub Date : 2024-04-01DOI: 10.47552/ijam.v15i1.4359
Srinivasan N
Argemone Mexicana L. (AM, Papaveraceae) is found and native to tropical America. Many cultures have traditionally used this annual herb to treat a variety of ailments, including skin disorders, digestive problems, eye issues, and anti-dotes. Argemone Mexicana (AM), a plant with a long history of traditional use, has recently gained renewed attention from researchers due to its potential pharmacological benefits. The possibility that this plant could be used to develop new therapies has inspired further research. Information about AM was collected from scientific databases published between January 2000 and March 2022. These databases include Elsevier, PubMed, Web of Science, NOPR, Google Scholar, ResearchGate, Wiley, SpringerLink, and ACS publications. Numerous chemical constituents present in AM have been found to have medicinal properties, such as alkaloids, flavonoids, tannins, phenolic compounds, saponin, terpenoids, and cardiac glycosides. Various parts of the AM plant exhibit antimicrobial, wound healing, antioxidant, antimalarial, larvicidal, anthelmintic, antidiabetic, hepatoprotective, anticancer effects, and have been used to treat sexually transmitted diseases. However, the plant is also known to be toxic, and its use can lead to a number of adverse effects, including dermatitis, gastrointestinal disturbances, and neurological damage. This review critically evaluates recent developments in the traditional use, phytochemistry, pharmacology, and toxicology of AM in order to provide a scientific basis for reasonable utilization and further research.
Argemone Mexicana L.（AM，木犀科）被发现并原产于美洲热带地区。许多文化传统上都使用这种一年生草本植物来治疗各种疾病，包括皮肤病、消化问题、眼疾和解毒药。Argemone Mexicana（AM）是一种传统使用历史悠久的植物，由于其潜在的药理作用，最近再次受到研究人员的关注。这种植物被用于开发新疗法的可能性激发了进一步的研究。有关 AM 的信息是从 2000 年 1 月至 2022 年 3 月期间发表的科学数据库中收集的。这些数据库包括 Elsevier、PubMed、Web of Science、NOPR、Google Scholar、ResearchGate、Wiley、SpringerLink 和 ACS 出版物。已发现 AM 中的许多化学成分具有药用特性，如生物碱、黄酮类、单宁、酚类化合物、皂苷、萜类化合物和强心苷。AM 植物的不同部分具有抗菌、伤口愈合、抗氧化、抗疟、杀幼虫剂、驱虫药、抗糖尿病、保肝、抗癌等作用，并被用于治疗性传播疾病。不过，已知该植物也有毒性，使用它可能会导致一系列不良反应，包括皮炎、肠胃功能紊乱和神经损伤。本综述对 AM 的传统用途、植物化学、药理学和毒理学方面的最新进展进行了批判性评估，以便为合理利用和进一步研究提供科学依据。
{"title":"Traditional uses, phytochemistry, pharmacological significance and toxicology of Argemone mexicana L. – A review approach","authors":"Srinivasan N","doi":"10.47552/ijam.v15i1.4359","DOIUrl":"https://doi.org/10.47552/ijam.v15i1.4359","url":null,"abstract":"Argemone Mexicana L. (AM, Papaveraceae) is found and native to tropical America. Many cultures have traditionally used this annual herb to treat a variety of ailments, including skin disorders, digestive problems, eye issues, and anti-dotes. Argemone Mexicana (AM), a plant with a long history of traditional use, has recently gained renewed attention from researchers due to its potential pharmacological benefits. The possibility that this plant could be used to develop new therapies has inspired further research. Information about AM was collected from scientific databases published between January 2000 and March 2022. These databases include Elsevier, PubMed, Web of Science, NOPR, Google Scholar, ResearchGate, Wiley, SpringerLink, and ACS publications. Numerous chemical constituents present in AM have been found to have medicinal properties, such as alkaloids, flavonoids, tannins, phenolic compounds, saponin, terpenoids, and cardiac glycosides. Various parts of the AM plant exhibit antimicrobial, wound healing, antioxidant, antimalarial, larvicidal, anthelmintic, antidiabetic, hepatoprotective, anticancer effects, and have been used to treat sexually transmitted diseases. However, the plant is also known to be toxic, and its use can lead to a number of adverse effects, including dermatitis, gastrointestinal disturbances, and neurological damage. This review critically evaluates recent developments in the traditional use, phytochemistry, pharmacology, and toxicology of AM in order to provide a scientific basis for reasonable utilization and further research.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140771888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.47552/ijam.v15i1.4794
S. Sv, Karishma Banu D, Rajitha C, Kalyani B, Samel I, Mohammad Saief ES
Aim and Objective: The current work was aimed at preparing the Hutabhugadi Churna in the laboratory and evaluating the same including the method development for the estimation of a marker compound Piperine by using RP-HPLC. Methods: Prepared Hutabhugadi churna was subjected for macroscopic, physical, and chemical evaluation considering WHO guidelines. The methanolic extract was subjected for estimation of Piperine as marker using RP-HPLC. Results: The macroscopic characteristics like colour, odour and taste are recorded. The physical characteristics like loss on drying, ash value, extractive value, swelling index, foaming index, powder properties like angle of repose, bulk density, tapped density, compressibility index etc. were determined. Total phenolic content, total flavonoid content, preliminary phytochemical screening was also carried out. The results are compared with marketed formulation of Hutabhugadi churna. The retention time of the standard Piperine was found to be 5.517, while the Piperine in extracts of laboratory and marketed formulations was found to be was found to be 5.554 and 5.562 respectively. The concentration of Piperine in laboratory and marketed formulation was found to be 0.17 %w/w and 0.18 % w/w respectively. The method developed was also validated. Conclusion: The laboratory made Hutabhugadi churna and marketed formulation of Hutabhugadi churna was comparatively evaluated. The resulting data will be useful for the standardization of the Hutabhugadi churna, an Ayurvedic formulation.
{"title":"Evaluation and method development for quantification of Piperine in Hutabhugadi Churna by RP- HPLC","authors":"S. Sv, Karishma Banu D, Rajitha C, Kalyani B, Samel I, Mohammad Saief ES","doi":"10.47552/ijam.v15i1.4794","DOIUrl":"https://doi.org/10.47552/ijam.v15i1.4794","url":null,"abstract":"Aim and Objective: The current work was aimed at preparing the Hutabhugadi Churna in the laboratory and evaluating the same including the method development for the estimation of a marker compound Piperine by using RP-HPLC. Methods: Prepared Hutabhugadi churna was subjected for macroscopic, physical, and chemical evaluation considering WHO guidelines. The methanolic extract was subjected for estimation of Piperine as marker using RP-HPLC. Results: The macroscopic characteristics like colour, odour and taste are recorded. The physical characteristics like loss on drying, ash value, extractive value, swelling index, foaming index, powder properties like angle of repose, bulk density, tapped density, compressibility index etc. were determined. Total phenolic content, total flavonoid content, preliminary phytochemical screening was also carried out. The results are compared with marketed formulation of Hutabhugadi churna. The retention time of the standard Piperine was found to be 5.517, while the Piperine in extracts of laboratory and marketed formulations was found to be was found to be 5.554 and 5.562 respectively. The concentration of Piperine in laboratory and marketed formulation was found to be 0.17 %w/w and 0.18 % w/w respectively. The method developed was also validated. Conclusion: The laboratory made Hutabhugadi churna and marketed formulation of Hutabhugadi churna was comparatively evaluated. The resulting data will be useful for the standardization of the Hutabhugadi churna, an Ayurvedic formulation.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140784886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.47552/ijam.v15i1.4140
Pravin M Bhat, Priyanka Bolke
Ayurveda can serve in many disease conditions, whereas conventional systems face several limitations. Diabetic Retinopathy (DR) is among such conditions, where effective management is becoming a challenge. Diabetic Retinopathy leads to visual disability and is one of the major complications of Diabetes Mellitus (DM). Currently available conventional treatments for DR have certain limitations; considering this fact, options from alternative resources are being searched. In Ayurveda, retinal diseases can be included in Drishtigata roga (~eye sight disorder) and DR can be correlated with Timir (~a class of morbid affections of the coats of the eye), as pathology of Timir is secondary to systemic Dosha Dushti (~vitiation of body humor) and DR can be considered as Pramehajanya Timir. A male patient of 61 years visited the Netra (ophthalmic) OPD complaining of defective distant and near vision for two months. Based upon the history of diabetes and clinical signs and symptoms, he was diagnosed with Non-Proliferative Diabetic Retinopathy (NPDR) in both eyes. The indirect ophthalmoscopy investigation was used to confirm the diagnosis. Nimi Nirdishta yoga which contains Triphala, Yashtimadhu (Glycyrrhiza glabra Linn.), and Ghrita was administered for one month daily at night with honey. At the end of one month, there was improvement noted in distant vision without glasses from 6/18 to 6/12 in the right eye and 6/9 to 6/6p in the left eye while near vision from N/8 to N/6 in both eyes with glasses. Indirect ophthalmoscopy revealed a reduction in exudates and hemorrhages. The observations reveal that Ayurvedic approaches are helpful in managing Diabetic Retinopathy.
{"title":"Improvement of visual acuity in non-proliferative diabetic retinopathy with Nimi Nirdishta Yoga- A case report","authors":"Pravin M Bhat, Priyanka Bolke","doi":"10.47552/ijam.v15i1.4140","DOIUrl":"https://doi.org/10.47552/ijam.v15i1.4140","url":null,"abstract":"Ayurveda can serve in many disease conditions, whereas conventional systems face several limitations. Diabetic Retinopathy (DR) is among such conditions, where effective management is becoming a challenge. Diabetic Retinopathy leads to visual disability and is one of the major complications of Diabetes Mellitus (DM). Currently available conventional treatments for DR have certain limitations; considering this fact, options from alternative resources are being searched. In Ayurveda, retinal diseases can be included in Drishtigata roga (~eye sight disorder) and DR can be correlated with Timir (~a class of morbid affections of the coats of the eye), as pathology of Timir is secondary to systemic Dosha Dushti (~vitiation of body humor) and DR can be considered as Pramehajanya Timir. A male patient of 61 years visited the Netra (ophthalmic) OPD complaining of defective distant and near vision for two months. Based upon the history of diabetes and clinical signs and symptoms, he was diagnosed with Non-Proliferative Diabetic Retinopathy (NPDR) in both eyes. The indirect ophthalmoscopy investigation was used to confirm the diagnosis. Nimi Nirdishta yoga which contains Triphala, Yashtimadhu (Glycyrrhiza glabra Linn.), and Ghrita was administered for one month daily at night with honey. At the end of one month, there was improvement noted in distant vision without glasses from 6/18 to 6/12 in the right eye and 6/9 to 6/6p in the left eye while near vision from N/8 to N/6 in both eyes with glasses. Indirect ophthalmoscopy revealed a reduction in exudates and hemorrhages. The observations reveal that Ayurvedic approaches are helpful in managing Diabetic Retinopathy.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140792968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.47552/ijam.v15i1.4255
Subhashri R, Periyasami D, Mahadevan Mv
Diabetic foot ulcer (DFU) is one of the most prevalent consequences for those with uncontrolled diabetes mellitus (DM). The annual incidence of DFU worldwide is between 9.1 to 26.1 million, the mortality and morbidity are the common reasons for hospitalisation of diabetes patients. The available treatment modalities are expensive and unsatisfactory in the clinical management of DFU. In Siddha system of medicine Diabetic ulcers are referred to as Madhumegha Viranam (MV). Various thailam (medicated oil) are used in the management of ulcers. Virana Sanjeevi thailam (VST) is one of the classical Siddha topical formulations indicated for the management of chronic ulcers. As this thailam is not been subjected to clinical evaluation yet, this case study is to report the effectiveness of wound dressing with VST along with adjuvant Siddha medications in 60 years old, post-menopausal, house wife who reported with complaints of ulcer in the plantar aspect of right foot for a period of 6 months, along with a past history of diabetes and systemic hypertension undergoing modern treatment for the past 10 years. The patient was diagnosed to have MV and the ulcer had features of Grade 2 in Maggit Wagner system of classification of diabetic ulcers, wound area was 12cm2, with pale granulation tissues and purulent discharges. Following treatment, ulcer healed completely in a span of 86 days and Leg Ulcer Measurement Tool score improved from 41/68 to 3/68. This may encourage the use of Siddha medicines in management of DFUs.
{"title":"The Effectiveness of Wound Dressing with Virana Sanjeevi Thailam (VST) in the Management of Madhumegha Viranam – A Case Report","authors":"Subhashri R, Periyasami D, Mahadevan Mv","doi":"10.47552/ijam.v15i1.4255","DOIUrl":"https://doi.org/10.47552/ijam.v15i1.4255","url":null,"abstract":"Diabetic foot ulcer (DFU) is one of the most prevalent consequences for those with uncontrolled diabetes mellitus (DM). The annual incidence of DFU worldwide is between 9.1 to 26.1 million, the mortality and morbidity are the common reasons for hospitalisation of diabetes patients. The available treatment modalities are expensive and unsatisfactory in the clinical management of DFU. In Siddha system of medicine Diabetic ulcers are referred to as Madhumegha Viranam (MV). Various thailam (medicated oil) are used in the management of ulcers. Virana Sanjeevi thailam (VST) is one of the classical Siddha topical formulations indicated for the management of chronic ulcers. As this thailam is not been subjected to clinical evaluation yet, this case study is to report the effectiveness of wound dressing with VST along with adjuvant Siddha medications in 60 years old, post-menopausal, house wife who reported with complaints of ulcer in the plantar aspect of right foot for a period of 6 months, along with a past history of diabetes and systemic hypertension undergoing modern treatment for the past 10 years. The patient was diagnosed to have MV and the ulcer had features of Grade 2 in Maggit Wagner system of classification of diabetic ulcers, wound area was 12cm2, with pale granulation tissues and purulent discharges. Following treatment, ulcer healed completely in a span of 86 days and Leg Ulcer Measurement Tool score improved from 41/68 to 3/68. This may encourage the use of Siddha medicines in management of DFUs. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140783966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.47552/ijam.v15i1.4758
Swati Bhingare, Rupaji Kadam
Medodhara Kala is the zone of transition between Meda Dhatu (Adipose Tissue) and Asthi Dhatu (Bone Tissue). So, any pathology in Medodhara kala is responsible for deprived Asthi Dhatu (Osteoporosis). Obesity is the condition where there is abnormal built-up of Meda Dhatu (Adipose tissue) altering the osteogenic potential of Adipose tissue. Among the various types of Obesity based on the fat accumulation at different fat depots, abdominal obesity is identified as the risk factor for the lower bone mineral density and resulting fracture. The present study aims to find the prevalence of osteoporosis among various types of obesity like generalised obesity, abdominal obesity, isolated Abdominal Obesity etc. Cross sectional survey was designed in which 100 subjects fulfilling inclusion criteria, willing to participate were enrolled in the study after obtaining informed consent. Participants were divided into two groups i.e. 50 Medoroga (obesity) patients and 50 non-obese volunteers between age group of 20 and 50 irrespective of genders. The collected data comprising Waist Circumference, Waist Hip ratio, BMI classification and other anthropological measurements and T-score was analysed using GraphPad InStat Version 3.6 software. Chi-Square test showed significant association (p<0.05) of osteoporosis or osteopenia in patients of generalised with abdominal obesity and isolated abdominal obesity, indicating that the prevalence of osteoporosis rises with increasing waist circumference. Significant association between visceral fat depot (Abdominal Obesity) with the bone mineral density, suggesting the osteogenic potential of Medodhara Kala which gets minimised with increase BMI (Body mass index).
Medodhara Kala 是 Meda Dhatu（脂肪组织）和 Asthi Dhatu（骨组织）之间的过渡区域。因此，Medodhara Kala 的任何病变都会导致 Asthi Dhatu（骨质疏松症）的缺失。肥胖是指 Meda Dhatu（脂肪组织）的异常堆积改变了脂肪组织的成骨潜能。根据不同脂肪堆积部位的脂肪堆积情况，肥胖分为多种类型，其中腹部肥胖被认为是导致骨矿密度降低和骨折的危险因素。本研究旨在了解骨质疏松症在各种类型肥胖（如全身性肥胖、腹型肥胖、孤立性腹型肥胖等）中的发病率。研究设计了横断面调查，在获得知情同意后，100 名符合纳入标准且愿意参与的受试者被纳入研究。受试者分为两组，即 50 名肥胖症患者和 50 名非肥胖志愿者，年龄介于 20 至 50 岁之间，不分性别。收集到的数据包括腰围、腰臀比、体重指数分类和其他人体测量数据，并使用 GraphPad InStat 3.6 版软件对 T 值进行了分析。Chi-Square 检验显示，全身性腹部肥胖和孤立性腹部肥胖患者的骨质疏松症或骨质疏松症有显著关联（P<0.05），表明骨质疏松症的患病率随腰围的增加而增加。内脏脂肪库（腹部肥胖）与骨质密度之间存在显著关联，表明 Medodhara Kala 的成骨潜力随着 BMI（体重指数）的增加而减弱。
{"title":"A Study to find the association between Obesity and Osteoporosis according to distinct fat depots - A survey study","authors":"Swati Bhingare, Rupaji Kadam","doi":"10.47552/ijam.v15i1.4758","DOIUrl":"https://doi.org/10.47552/ijam.v15i1.4758","url":null,"abstract":"Medodhara Kala is the zone of transition between Meda Dhatu (Adipose Tissue) and Asthi Dhatu (Bone Tissue). So, any pathology in Medodhara kala is responsible for deprived Asthi Dhatu (Osteoporosis). Obesity is the condition where there is abnormal built-up of Meda Dhatu (Adipose tissue) altering the osteogenic potential of Adipose tissue. Among the various types of Obesity based on the fat accumulation at different fat depots, abdominal obesity is identified as the risk factor for the lower bone mineral density and resulting fracture. The present study aims to find the prevalence of osteoporosis among various types of obesity like generalised obesity, abdominal obesity, isolated Abdominal Obesity etc. Cross sectional survey was designed in which 100 subjects fulfilling inclusion criteria, willing to participate were enrolled in the study after obtaining informed consent. Participants were divided into two groups i.e. 50 Medoroga (obesity) patients and 50 non-obese volunteers between age group of 20 and 50 irrespective of genders. The collected data comprising Waist Circumference, Waist Hip ratio, BMI classification and other anthropological measurements and T-score was analysed using GraphPad InStat Version 3.6 software. Chi-Square test showed significant association (p<0.05) of osteoporosis or osteopenia in patients of generalised with abdominal obesity and isolated abdominal obesity, indicating that the prevalence of osteoporosis rises with increasing waist circumference. Significant association between visceral fat depot (Abdominal Obesity) with the bone mineral density, suggesting the osteogenic potential of Medodhara Kala which gets minimised with increase BMI (Body mass index).","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140755757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.47552/ijam.v15i1.3344
Tamilarasan G, G. R, P. E, Hema Rn
Within the realm of Siddha medicine, an ancient and venerable traditional healing system hailing from India, a comprehensive methodology is deployed to combat liver disorders. This approach is characterised by the utilisation of herbal remedies, accentuating the reinstatement of equilibrium in the body's vital life force, known as "Vatham," "Pitham," and "Kapham." The utilisation of cell line studies is crucial in assessing the immunomodulatory properties of herbal medicine, offering invaluable insights into their capacity to influence the immune system and advancing our comprehension of their therapeutic benefits. The primary objective of this investigation was to elucidate the potential immunomodulatory properties of sagalanoi chooranam, a polyherbal Siddha formulation, through the execution of anti-proliferative assays conducted. On the RAW 264.7 macrophage cell line. Various test solutions were precisely prepared, encompassing a spectrum of concentrations (50, 100 and 200 μg/ml). The RAW 264.7 cells were diligently cultured and then carefully subjected to stimulation with lipopolysaccharide (LPS) to initiate cellular activation. Following this activation, the test formulation was introduced at varying concentrations, after which the cells underwent a 24-hour incubation period. The resultant nitrite levels, serving as indicators of immunomodulatory response, were evaluated within the cell lysate. The outcomes unveiled a notable decline in nitrite levels, correlating with the dosage of the test formulation during the incubation with RAW 264.7 cells. The outcomes of the study elucidate a conspicuous decline in nitrite levels in direct correlation with escalating concentrations of the test formulation, contrasting starkly with the control group exclusively subjected to LPS. Furthermore, the investigation meticulously probed the ramifications of the test formulation on cellular viability. The vitality of RAW 264.7 cells exhibited a discernible downward trajectory as the concentration of the test formulation ascended. Noteworthy is the fact that, at the concentration of 200 μg/ml, cellular viability registered at a mere 55.53 ± 3.567%. Collectively, these findings lend credence to the hypothesis that the test formulation possesses a dose-dependent capacity to attenuate both nitrite levels and cellular viability within the RAW 264.7 cell milieu, underscoring its auspicious immunomodulatory attributes. This research expands our insights into the potential immunological ramifications of the test formulation and underscores its plausible utility within the realm of immunomodulation.
{"title":"In Vitro Immunomodulatory Activity of Sagalanoi Chooranam (Poly Herbal Formulation) in RAW Macrophage Cell Line","authors":"Tamilarasan G, G. R, P. E, Hema Rn","doi":"10.47552/ijam.v15i1.3344","DOIUrl":"https://doi.org/10.47552/ijam.v15i1.3344","url":null,"abstract":"Within the realm of Siddha medicine, an ancient and venerable traditional healing system hailing from India, a comprehensive methodology is deployed to combat liver disorders. This approach is characterised by the utilisation of herbal remedies, accentuating the reinstatement of equilibrium in the body's vital life force, known as \"Vatham,\" \"Pitham,\" and \"Kapham.\" The utilisation of cell line studies is crucial in assessing the immunomodulatory properties of herbal medicine, offering invaluable insights into their capacity to influence the immune system and advancing our comprehension of their therapeutic benefits. The primary objective of this investigation was to elucidate the potential immunomodulatory properties of sagalanoi chooranam, a polyherbal Siddha formulation, through the execution of anti-proliferative assays conducted. On the RAW 264.7 macrophage cell line. Various test solutions were precisely prepared, encompassing a spectrum of concentrations (50, 100 and 200 μg/ml). The RAW 264.7 cells were diligently cultured and then carefully subjected to stimulation with lipopolysaccharide (LPS) to initiate cellular activation. Following this activation, the test formulation was introduced at varying concentrations, after which the cells underwent a 24-hour incubation period. The resultant nitrite levels, serving as indicators of immunomodulatory response, were evaluated within the cell lysate. The outcomes unveiled a notable decline in nitrite levels, correlating with the dosage of the test formulation during the incubation with RAW 264.7 cells. The outcomes of the study elucidate a conspicuous decline in nitrite levels in direct correlation with escalating concentrations of the test formulation, contrasting starkly with the control group exclusively subjected to LPS. Furthermore, the investigation meticulously probed the ramifications of the test formulation on cellular viability. The vitality of RAW 264.7 cells exhibited a discernible downward trajectory as the concentration of the test formulation ascended. Noteworthy is the fact that, at the concentration of 200 μg/ml, cellular viability registered at a mere 55.53 ± 3.567%. Collectively, these findings lend credence to the hypothesis that the test formulation possesses a dose-dependent capacity to attenuate both nitrite levels and cellular viability within the RAW 264.7 cell milieu, underscoring its auspicious immunomodulatory attributes. This research expands our insights into the potential immunological ramifications of the test formulation and underscores its plausible utility within the realm of immunomodulation. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140783097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.47552/ijam.v15i1.4267
Sukeshini B. Lote, Mahendra Kshirsagar, Deepak Mohale, Anil Chandewar
The global occurrence of diabetes has witnessed persistent escalation, starting from 151 million individuals in the year 2000, the time when the IDF Diabetes Atlas was initially introduced, to 285 million in 2009, and further reaching 382 million in 2013. Diabetes mellitus is characterized by elevated levels of glucose in the blood plasma. This condition emerges as a consequence of insufficient insulin secretion, insulin resistance or both, subsequently leading to metabolic abnormalities. The plant known as Barleria buxifolia (BB), belonging to the Acanthaceae family, is intended to possess the ability to treat various ailments in the traditional Indian system of medicine. Hence, this research aims to investigate the effects of methanolic and aqueous extracts of BB leaves on diabetic models of rats. STZ (60 mg/kg) was administered to induce diabetes in the rats. Both the extracts of BB were orally administered at doses of 200 and 400 mg/kg, respectively to the normal and diabetic rats, commencing from the 3rd day until the 28th day. Blood samples were examined to determine glucose levels. The diabetic rats exhibited a notable rise in blood glucose levels. The aqueous and methanolic extracts of BB reduced the elevated glucose levels significantly (P > 0.01) and enhanced the body weight of rats. Thus, it can be inferred that BB possesses considerable potential for the management of diabetes mellitus.
{"title":"Beneficial effect of Barleria buxifolia leaves extract in the treatment of diabetes and associated complications","authors":"Sukeshini B. Lote, Mahendra Kshirsagar, Deepak Mohale, Anil Chandewar","doi":"10.47552/ijam.v15i1.4267","DOIUrl":"https://doi.org/10.47552/ijam.v15i1.4267","url":null,"abstract":"The global occurrence of diabetes has witnessed persistent escalation, starting from 151 million individuals in the year 2000, the time when the IDF Diabetes Atlas was initially introduced, to 285 million in 2009, and further reaching 382 million in 2013. Diabetes mellitus is characterized by elevated levels of glucose in the blood plasma. This condition emerges as a consequence of insufficient insulin secretion, insulin resistance or both, subsequently leading to metabolic abnormalities. The plant known as Barleria buxifolia (BB), belonging to the Acanthaceae family, is intended to possess the ability to treat various ailments in the traditional Indian system of medicine. Hence, this research aims to investigate the effects of methanolic and aqueous extracts of BB leaves on diabetic models of rats. STZ (60 mg/kg) was administered to induce diabetes in the rats. Both the extracts of BB were orally administered at doses of 200 and 400 mg/kg, respectively to the normal and diabetic rats, commencing from the 3rd day until the 28th day. Blood samples were examined to determine glucose levels. The diabetic rats exhibited a notable rise in blood glucose levels. The aqueous and methanolic extracts of BB reduced the elevated glucose levels significantly (P > 0.01) and enhanced the body weight of rats. Thus, it can be inferred that BB possesses considerable potential for the management of diabetes mellitus.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140766343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.47552/ijam.v15i1.4342
S. Salunkhe, Trupti Patil Bhole, Dattatraya Shinde
Background: COVID-19 is an infectious disease caused by the newly discovered coronavirus. COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-COV2). Post-COVID syndrome for people who still have symptoms for more than 12 weeks after the start of acute symptoms. This may last up to one year. The most common symptoms reported are fatigue, anorexia, joint pain, dyspnoea, headache, anxiety, and critical manifestations like diabetes, hypertension, pulmonary fibrosis, renal failure, Rheumatoid Arthritis (RA), etc. Agnimandya (~diminution of Agni) is a residual symptom of COVID-19 which leads to Dhatukshya (~diminution of Dhatu). Methods: We describe a case of a 50-year-old male who developed arthralgia after the remission of acute COVID-19 infection and post-COVID symptoms. The patient was treated with Haritakyadi yoga for koshtha shuddhi followed by Rasayana chikitsa by Amalaki Rasayana for the next 30 days for post-COVID ailments. The prime aim of treatment was to recover the function of Agni and koshtha shuddhi by administering Haritakyadi yoga followed by rejuvenation treatment by Amalaki Rasayana. The patient was assessed using the WHO well-being index scale, signs- and symptoms of post-COVID, six-minute walk test on the 0th, 15th, and 30th day follow-up. Results: Haritakyadi yoga followed by Amalaki Rasayana reduced symptoms of post-COVID arthralgia, improved energy levels of post-COVID symptoms, and enhanced WHO- well-being score. Conclusions: It is suggested by the mentioned case that Amalaki Rasayana may be used for managing post-COVID arthralgia and for improving general well-being in long COVID.
{"title":"Management of post COVID arthralgia by Amalaki Rasayana: A case report","authors":"S. Salunkhe, Trupti Patil Bhole, Dattatraya Shinde","doi":"10.47552/ijam.v15i1.4342","DOIUrl":"https://doi.org/10.47552/ijam.v15i1.4342","url":null,"abstract":"Background: COVID-19 is an infectious disease caused by the newly discovered coronavirus. COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-COV2). Post-COVID syndrome for people who still have symptoms for more than 12 weeks after the start of acute symptoms. This may last up to one year. The most common symptoms reported are fatigue, anorexia, joint pain, dyspnoea, headache, anxiety, and critical manifestations like diabetes, hypertension, pulmonary fibrosis, renal failure, Rheumatoid Arthritis (RA), etc. Agnimandya (~diminution of Agni) is a residual symptom of COVID-19 which leads to Dhatukshya (~diminution of Dhatu). Methods: We describe a case of a 50-year-old male who developed arthralgia after the remission of acute COVID-19 infection and post-COVID symptoms. The patient was treated with Haritakyadi yoga for koshtha shuddhi followed by Rasayana chikitsa by Amalaki Rasayana for the next 30 days for post-COVID ailments. The prime aim of treatment was to recover the function of Agni and koshtha shuddhi by administering Haritakyadi yoga followed by rejuvenation treatment by Amalaki Rasayana. The patient was assessed using the WHO well-being index scale, signs- and symptoms of post-COVID, six-minute walk test on the 0th, 15th, and 30th day follow-up. Results: Haritakyadi yoga followed by Amalaki Rasayana reduced symptoms of post-COVID arthralgia, improved energy levels of post-COVID symptoms, and enhanced WHO- well-being score. Conclusions: It is suggested by the mentioned case that Amalaki Rasayana may be used for managing post-COVID arthralgia and for improving general well-being in long COVID.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140764495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.47552/ijam.v15i1.4565
Aparna Sudhan, Prabhu K, Deepalakkshmi Balakrishnan, Sumathi Jones, Mudiganthi Ramakrishna Rao, K. M
Ayurvedic tailams have a long history of use and efficacy. They have been used for centuries, with many individuals reporting positive results in managing and improving their health. Ayurvedic tailams typically have fewer side effects compared to synthetic medications, making them a preferred choice for individuals seeking natural remedies and can be applied both externally (for massage) and, in some cases, internally (for specific therapies). This versatility allows for a wide range of applications and health benefits.The current study focuses on the GC MS analysis of Arukaladi tailam, an oil composition used in Ayurveda to treat jaundice when administered topically. Before being subjected to the GC MS analysis, the product was appropriately prepared after being purchased from a reputable Ayurvedic dealer in Chennai, India. The IC50 value of the DPPH assay was found to be 744.7391μl/ml and FRAP reveals that the tailam had good reducing power. Further the anti-inflammatory of the tailam exhibited 14.2% of haemolysis at 1000μl/ml and inhibited protein denaturation by 63.74% with an IC50 value of 789.4013 µl/ml. The presence of biomolecules as shown in the GC MS profile are 2-Fluoro-6-trifluoromethylbenzoic acid, 2- tetradecyl ester, Tridecanol, 2-ethyl-2-methyl-, etc. These chemicals could help the medication work better to treat jaundice.
{"title":"The GCMS, antioxidant, and anti-inflammatory activity of the Ayurveda oil, Arukaladi tailam","authors":"Aparna Sudhan, Prabhu K, Deepalakkshmi Balakrishnan, Sumathi Jones, Mudiganthi Ramakrishna Rao, K. M","doi":"10.47552/ijam.v15i1.4565","DOIUrl":"https://doi.org/10.47552/ijam.v15i1.4565","url":null,"abstract":"Ayurvedic tailams have a long history of use and efficacy. They have been used for centuries, with many individuals reporting positive results in managing and improving their health. Ayurvedic tailams typically have fewer side effects compared to synthetic medications, making them a preferred choice for individuals seeking natural remedies and can be applied both externally (for massage) and, in some cases, internally (for specific therapies). This versatility allows for a wide range of applications and health benefits.The current study focuses on the GC MS analysis of Arukaladi tailam, an oil composition used in Ayurveda to treat jaundice when administered topically. Before being subjected to the GC MS analysis, the product was appropriately prepared after being purchased from a reputable Ayurvedic dealer in Chennai, India. The IC50 value of the DPPH assay was found to be 744.7391μl/ml and FRAP reveals that the tailam had good reducing power. Further the anti-inflammatory of the tailam exhibited 14.2% of haemolysis at 1000μl/ml and inhibited protein denaturation by 63.74% with an IC50 value of 789.4013 µl/ml. The presence of biomolecules as shown in the GC MS profile are 2-Fluoro-6-trifluoromethylbenzoic acid, 2- tetradecyl ester, Tridecanol, 2-ethyl-2-methyl-, etc. These chemicals could help the medication work better to treat jaundice.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140768281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.47552/ijam.v15i1.4541
Laxmikant S Paymalle, N. Wadnerwar
Aparajita (Clitoria ternatea Linn), is an herb widely distributed in the humid, lowland tropics of Africa, Asia, and Central America. Aparajita is known for its katu, tikta, kashaya rasa, and vishaghna (which alleviate toxins) properties. It is used in the treatment of various diseases and is a major ingredient in various anti-poisonous formulations. Pharmacologically, it has actions like insecticidal, cholinergic, antioxytocic, antihistaminic, analgesic, diuretic, purgative, laxative, and abortifacient. A systematic review is attempted based on preclinical studies to prepare a strong platform for the clinical utilisation of Aparajita as a main drug. The research papers reporting the study of Clitoria ternatea Linn in animals (In vivo and in vitro) were searched for systematic review. The literature search was performed using keywords like 'preclinical studies on Aparajita,' 'animal studies on Aparajita,' and 'pharmacological studies on Aparajita,' in combination with various effects in animals, in the following databases: PubMed/Medline, Scopus, Science Direct, Google Scholar, AYUSH Research Portal, and DHARA for studies published up to December 2021. Many preclinical studies reported that Clitoria ternatea Linn has diuretic, nootropic, anti-asthmatic, anti-inflammatory, analgesic, antipyretic, antidiabetic, antilipidemic, antioxidant, and wound healing properties. In the contemporary view, several pharmacological studies and preclinical studies prove the effectiveness of Clitoria ternatea Linn in various diseases. However, very few clinical studies of Clitoria ternatea Linn were done. Further clinical research should be conducted to establish the therapeutic potential of the drug Aparajita.
{"title":"A systematic review on exploration of therapeutic potential of Aparajita (Clitoria Ternatea Linn)","authors":"Laxmikant S Paymalle, N. Wadnerwar","doi":"10.47552/ijam.v15i1.4541","DOIUrl":"https://doi.org/10.47552/ijam.v15i1.4541","url":null,"abstract":"Aparajita (Clitoria ternatea Linn), is an herb widely distributed in the humid, lowland tropics of Africa, Asia, and Central America. Aparajita is known for its katu, tikta, kashaya rasa, and vishaghna (which alleviate toxins) properties. It is used in the treatment of various diseases and is a major ingredient in various anti-poisonous formulations. Pharmacologically, it has actions like insecticidal, cholinergic, antioxytocic, antihistaminic, analgesic, diuretic, purgative, laxative, and abortifacient. A systematic review is attempted based on preclinical studies to prepare a strong platform for the clinical utilisation of Aparajita as a main drug. The research papers reporting the study of Clitoria ternatea Linn in animals (In vivo and in vitro) were searched for systematic review. The literature search was performed using keywords like 'preclinical studies on Aparajita,' 'animal studies on Aparajita,' and 'pharmacological studies on Aparajita,' in combination with various effects in animals, in the following databases: PubMed/Medline, Scopus, Science Direct, Google Scholar, AYUSH Research Portal, and DHARA for studies published up to December 2021. Many preclinical studies reported that Clitoria ternatea Linn has diuretic, nootropic, anti-asthmatic, anti-inflammatory, analgesic, antipyretic, antidiabetic, antilipidemic, antioxidant, and wound healing properties. In the contemporary view, several pharmacological studies and preclinical studies prove the effectiveness of Clitoria ternatea Linn in various diseases. However, very few clinical studies of Clitoria ternatea Linn were done. Further clinical research should be conducted to establish the therapeutic potential of the drug Aparajita.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140774882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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