Pub Date : 2024-10-04DOI: 10.1016/j.ijoes.2024.100821
Tao Zhong , Zuhua Jiang , Yuxuan Xing , Sicong Jiang , Yuan Wu , Shiyuan Yao
This study presents the development of an electrochemical immunosensor utilizing gold nanoparticles for the detection of creatine kinase (CK), a crucial cardiac marker. Gold nanoparticles with an average diameter of 18.3 ± 2.1 nm were synthesized and characterized, exhibiting a characteristic surface plasmon resonance peak at 520 nm. The construction of the immunosensor was observed through cyclic voltammetry and electrochemical impedance spectroscopy, showing notable alterations in electron transfer rates during each step of the assembly process. Optimal performance was achieved at pH 7.4, with an antibody concentration of 100 μg/mL and an incubation time of 45 minutes. The sensor demonstrated a sensitivity of 152.6 Ω/(ng/mL) and maintained its response in the presence of common interfering substances, with maximum signal deviation of 7.2 %. Testing with spiked human serum samples yielded recovery rates between 96.5 % and 103.8 %. Comparison with ELISA using clinical samples further validated the sensor's accuracy. This AuNP-based immunosensor offers a promising platform for rapid and sensitive CK detection in cardiac health assessment.
{"title":"Electrochemical immunosensor based on gold nanoparticles for the detection of creatine kinase as a cardiac marker","authors":"Tao Zhong , Zuhua Jiang , Yuxuan Xing , Sicong Jiang , Yuan Wu , Shiyuan Yao","doi":"10.1016/j.ijoes.2024.100821","DOIUrl":"10.1016/j.ijoes.2024.100821","url":null,"abstract":"<div><div>This study presents the development of an electrochemical immunosensor utilizing gold nanoparticles for the detection of creatine kinase (CK), a crucial cardiac marker. Gold nanoparticles with an average diameter of 18.3 ± 2.1 nm were synthesized and characterized, exhibiting a characteristic surface plasmon resonance peak at 520 nm. The construction of the immunosensor was observed through cyclic voltammetry and electrochemical impedance spectroscopy, showing notable alterations in electron transfer rates during each step of the assembly process. Optimal performance was achieved at pH 7.4, with an antibody concentration of 100 μg/mL and an incubation time of 45 minutes. The sensor demonstrated a sensitivity of 152.6 Ω/(ng/mL) and maintained its response in the presence of common interfering substances, with maximum signal deviation of 7.2 %. Testing with spiked human serum samples yielded recovery rates between 96.5 % and 103.8 %. Comparison with ELISA using clinical samples further validated the sensor's accuracy. This AuNP-based immunosensor offers a promising platform for rapid and sensitive CK detection in cardiac health assessment.</div></div>","PeriodicalId":13872,"journal":{"name":"International Journal of Electrochemical Science","volume":"19 11","pages":"Article 100821"},"PeriodicalIF":1.3,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142424400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-04DOI: 10.1016/j.ijoes.2024.100814
Danica Moodley, Allen Mambanda, Irvin Noel Booysen
This research study describes the nanofabrication of electrospun nanofibers (ENFs) containing a coumarin tetra-substituted cobalt phthalocyanine (CoPc-cou), polyaniline (PANI) and polyvinyl alcohol (PVA). This nanocomposite was used to modify a gold substrate which was followed by the immobilisation of a 5 % Nafion (Nf) solution affording the CoPc-cou-ENFs-Nf|Au modified electrode. Comparison of the chemically modified electrode (CME) with the bare and other modified electrodes shows that the CME under optimised conditions displayed superior detection of Hg(II) attaining a linear range of 10 – 3000 µM. Furthermore, the CME exhibits selectivity and sensitivity in an interference sample containing multiple heavy metals. A good percentage recovery of 96 % was attained when the CoPc-cou-ENFs-Nf|Au electrode was applied to a real water sample which was comparable to a percentage recovery of 98 % which was attained using the ICP-OES to analyse the same water samples.
{"title":"Immobilization of cobalt phthalocyanine-imbedded electrospun nanofibers on a gold electrode for the electrocatalytic detection of mercury(II)","authors":"Danica Moodley, Allen Mambanda, Irvin Noel Booysen","doi":"10.1016/j.ijoes.2024.100814","DOIUrl":"10.1016/j.ijoes.2024.100814","url":null,"abstract":"<div><div>This research study describes the nanofabrication of electrospun nanofibers (ENFs) containing a coumarin <em>tetra</em>-substituted cobalt phthalocyanine (CoPc-cou), polyaniline (PANI) and polyvinyl alcohol (PVA). This nanocomposite was used to modify a gold substrate which was followed by the immobilisation of a 5 % Nafion (Nf) solution affording the CoPc-cou-ENFs-Nf|Au modified electrode. Comparison of the chemically modified electrode (CME) with the bare and other modified electrodes shows that the CME under optimised conditions displayed superior detection of Hg(II) attaining a linear range of 10 – 3000 <em>µ</em>M. Furthermore, the CME exhibits selectivity and sensitivity in an interference sample containing multiple heavy metals. A good percentage recovery of 96 % was attained when the CoPc-cou-ENFs-Nf|Au electrode was applied to a real water sample which was comparable to a percentage recovery of 98 % which was attained using the ICP-OES to analyse the same water samples.</div></div>","PeriodicalId":13872,"journal":{"name":"International Journal of Electrochemical Science","volume":"19 11","pages":"Article 100814"},"PeriodicalIF":1.3,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142424394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-03DOI: 10.1016/j.ijoes.2024.100820
Jun Yang , Yong Zhou , Fuan Yan , Baomin Fan , Yunxuan Wen
In order to understand the effect of drying-wetting alternation on the corrosion resistance of rusted weathering steel, firstly, a rusted weathering steel was obtaioned through the preparation of stabilized rust layer on the surface of naked weathering steel; secondly, a cyclic corrosion test (CCT) of drying-wetting alternation with different cyclic periods was carried out for rusted weathering steel. With the extension of cyclic period in drying-wetting CCT, the corrosion resistance of rusted weathering steel increased from 0 cycle to 6 cycle and then decreased after 6 cycle, which was closely associated with the variations of composition and microstructure for stabilized rust layer during the process of drying-wetting CCT. From 0 cycle to 6 cycle, the increased corrosion resistance of rusted weathering steel was attributed to the abundance rise of α-FeOOH in the interior of stabilized rust layer; however, from 6 cycle to 20 cycle, the decreased corrosion resistance of rusted weathering steel was due to the partial destruction of crystal sturcuture for stabilized rust layer.
{"title":"The effect of drying-wetting alternation on corrosion resistance of rusted weathering steel","authors":"Jun Yang , Yong Zhou , Fuan Yan , Baomin Fan , Yunxuan Wen","doi":"10.1016/j.ijoes.2024.100820","DOIUrl":"10.1016/j.ijoes.2024.100820","url":null,"abstract":"<div><div>In order to understand the effect of drying-wetting alternation on the corrosion resistance of rusted weathering steel, firstly, a rusted weathering steel was obtaioned through the preparation of stabilized rust layer on the surface of naked weathering steel; secondly, a cyclic corrosion test (CCT) of drying-wetting alternation with different cyclic periods was carried out for rusted weathering steel. With the extension of cyclic period in drying-wetting CCT, the corrosion resistance of rusted weathering steel increased from 0 cycle to 6 cycle and then decreased after 6 cycle, which was closely associated with the variations of composition and microstructure for stabilized rust layer during the process of drying-wetting CCT. From 0 cycle to 6 cycle, the increased corrosion resistance of rusted weathering steel was attributed to the abundance rise of α-FeOOH in the interior of stabilized rust layer; however, from 6 cycle to 20 cycle, the decreased corrosion resistance of rusted weathering steel was due to the partial destruction of crystal sturcuture for stabilized rust layer.</div></div>","PeriodicalId":13872,"journal":{"name":"International Journal of Electrochemical Science","volume":"19 11","pages":"Article 100820"},"PeriodicalIF":1.3,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142424298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This paper reports the attachment of p-aminobenzene sulfonic acid on the surface of magnetic Fe3O4-reduced graphene oxide. Different techniques including FTIR, UV, EIS, XRD, and SEM imaging were employed for characterization. The finding indicates the successful attachment of the p-aminobenzene sulfonic acid to the surface. The synthesized material was used to make a carbon paste electrode for the determination of the essential amino acid L-tryptophan (L-Try). EIS and CV characterization of the electrode further confirms the attachment of the acid. Of the different electrode materials used, the p-aminobenzene sulfonic acid attached magnetic Fe3O4 reduced graphene oxide showed very good electrocatalytic activity. The scan rate study showed that the electrode process is an adsorption-controlled one. The prepared electrode material gave a linear curve for 0.001 μM to 10 μM L-Try concentrations, and the limit of detection and limit of quantification were 0.26 nM and 0.78 nM, respectively. Furthermore, the electrode material was employed for the determination of L-Try in a milk and banana sample.
{"title":"Attachment of ρ-aminobenzene sulphonic acid into magnetic Fe3O4 reduced graphene oxide and its application for sensitive determination of L-tryptophan in milk and banana samples","authors":"Tarekegn Getinet Admasu , Tesfu Hailu Halefom , Siraye Esubalew Debebe","doi":"10.1016/j.ijoes.2024.100819","DOIUrl":"10.1016/j.ijoes.2024.100819","url":null,"abstract":"<div><div>This paper reports the attachment of <em>p</em>-aminobenzene sulfonic acid on the surface of magnetic Fe<sub>3</sub>O<sub>4</sub>-reduced graphene oxide. Different techniques including FTIR, UV, EIS, XRD, and SEM imaging were employed for characterization. The finding indicates the successful attachment of the <em>p</em>-aminobenzene sulfonic acid to the surface. The synthesized material was used to make a carbon paste electrode for the determination of the essential amino acid L-tryptophan (L-Try). EIS and CV characterization of the electrode further confirms the attachment of the acid. Of the different electrode materials used, the <em>p</em>-aminobenzene sulfonic acid attached magnetic Fe<sub>3</sub>O<sub>4</sub> reduced graphene oxide showed very good electrocatalytic activity. The scan rate study showed that the electrode process is an adsorption-controlled one. The prepared electrode material gave a linear curve for 0.001 μM to 10 μM L-Try concentrations, and the limit of detection and limit of quantification were 0.26 nM and 0.78 nM, respectively. Furthermore, the electrode material was employed for the determination of L-Try in a milk and banana sample.</div></div>","PeriodicalId":13872,"journal":{"name":"International Journal of Electrochemical Science","volume":"19 11","pages":"Article 100819"},"PeriodicalIF":1.3,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142434018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01DOI: 10.1016/j.ijoes.2024.100810
Isabely M.G. Abreu, Victória A. Maia, Rodrigo F.B. de Souza, Almir O. Neto
PdAu electrocatalysts were prepared in different atomic compositions supported on ITO by sodium Borohydride process. XRD results show intense crystalline peaks related to ITO, which may mask the appearance of less crystalline Pd or Au phases. Transmission results indicate agglomeration of palladium and gold nanoparticles on the support, a phenomenon compatible with metal oxide supports. Cyclic voltammograms in the absence of urea display characteristics commonly observed for PdAu electrodes, with an increase in oxygenated species compared to pure Pd or Au. Voltammograms in the presence of urea showed oxidation processes and lower current values, indicating catalyst deactivation processes. PdAu 75:25 demonstrated higher power density values compared to other prepared electrocatalysts, suggesting a synergy between Pd and Au for urea oxidation reaction.
通过硼氢化钠工艺制备了不同原子组成的钯金电催化剂，并将其支撑在 ITO 上。XRD 结果显示出与 ITO 有关的强烈结晶峰，这可能掩盖了结晶度较低的钯或金相的出现。透射结果表明，钯和金纳米颗粒在支撑物上聚集，这种现象与金属氧化物支撑物相符。在没有尿素的情况下，循环伏安图显示出钯金电极常见的特征，与纯钯或金相比，含氧物种有所增加。有尿素存在时的伏安图显示了氧化过程和较低的电流值，表明催化剂失活过程。与其他制备的电催化剂相比，钯金 75:25 显示出更高的功率密度值，表明钯和金在尿素氧化反应中具有协同作用。
{"title":"Synthesis and performance of PdAu/ITO electrocatalysts in urea oxidation reaction","authors":"Isabely M.G. Abreu, Victória A. Maia, Rodrigo F.B. de Souza, Almir O. Neto","doi":"10.1016/j.ijoes.2024.100810","DOIUrl":"10.1016/j.ijoes.2024.100810","url":null,"abstract":"<div><div>PdAu electrocatalysts were prepared in different atomic compositions supported on ITO by sodium Borohydride process. XRD results show intense crystalline peaks related to ITO, which may mask the appearance of less crystalline Pd or Au phases. Transmission results indicate agglomeration of palladium and gold nanoparticles on the support, a phenomenon compatible with metal oxide supports. Cyclic voltammograms in the absence of urea display characteristics commonly observed for PdAu electrodes, with an increase in oxygenated species compared to pure Pd or Au. Voltammograms in the presence of urea showed oxidation processes and lower current values, indicating catalyst deactivation processes. PdAu 75:25 demonstrated higher power density values compared to other prepared electrocatalysts, suggesting a synergy between Pd and Au for urea oxidation reaction.</div></div>","PeriodicalId":13872,"journal":{"name":"International Journal of Electrochemical Science","volume":"19 10","pages":"Article 100810"},"PeriodicalIF":1.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142421494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01DOI: 10.1016/j.ijoes.2024.100808
Hyeong-Ki Kim , Jin-Won Nam , Seung-Jun Kwon
This study examines the corrosion behavior of steel tendons for prestressed concrete (PSC) structures under varying chloride concentrations and [Cl-]/[OH-] ratios. Tendons were exposed to controlled wet conditions, with chloride concentrations ranging from 0.0 to 0.25 mol/L, and [Cl-]/[OH-] ratios from 0.3 to 0.9. Results showed significant corrosion even at low chloride levels, with corrosion current density escalating from "high-risk" to "severe" as chloride concentration increased. The study also found that complete grouting is critical, as tendons exposed to humid environments without proper protection corrode significantly, irrespective of the chloride content. The findings suggest that traditional "critical chloride content" concepts may not apply to PSC tendons, highlighting the need for meticulous grout quality control to prevent corrosion. This research provides essential insights into the factors influencing tendon corrosion, offering guidance for improving PSC durability.
{"title":"Corrosion behavior of ASTM A416 tendon steel in wet conditions under various chloride concentrations","authors":"Hyeong-Ki Kim , Jin-Won Nam , Seung-Jun Kwon","doi":"10.1016/j.ijoes.2024.100808","DOIUrl":"10.1016/j.ijoes.2024.100808","url":null,"abstract":"<div><div>This study examines the corrosion behavior of steel tendons for prestressed concrete (PSC) structures under varying chloride concentrations and [Cl<sup>-</sup>]/[OH<sup>-</sup>] ratios. Tendons were exposed to controlled wet conditions, with chloride concentrations ranging from 0.0 to 0.25 mol/L, and [Cl<sup>-</sup>]/[OH<sup>-</sup>] ratios from 0.3 to 0.9. Results showed significant corrosion even at low chloride levels, with corrosion current density escalating from \"high-risk\" to \"severe\" as chloride concentration increased. The study also found that complete grouting is critical, as tendons exposed to humid environments without proper protection corrode significantly, irrespective of the chloride content. The findings suggest that traditional \"critical chloride content\" concepts may not apply to PSC tendons, highlighting the need for meticulous grout quality control to prevent corrosion. This research provides essential insights into the factors influencing tendon corrosion, offering guidance for improving PSC durability.</div></div>","PeriodicalId":13872,"journal":{"name":"International Journal of Electrochemical Science","volume":"19 10","pages":"Article 100808"},"PeriodicalIF":1.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01DOI: 10.1016/j.ijoes.2024.100807
Hao Deng, Shangyao Mo, Yong Xie, Rong Chen
This study presents a novel electrochemical biosensor for the detection of Helicobacter pylori VacA protein using a graphene-Au nanocomposite platform. The nanocomposite was synthesized via a one-pot reduction method and characterized using SEM, XRD, and FTIR. The biosensor fabrication process was monitored through cyclic voltammetry and electrochemical impedance spectroscopy. Optimization studies revealed ideal conditions of pH 7.4, 30-minute incubation time, and 100 μg/mL antibody concentration. The biosensor exhibited a linear response range of 0.1–100 ng/mL with a detection limit of 0.03 ng/mL. Selectivity tests against common interfering substances showed minimal cross-reactivity (<5 % signal change). The sensor demonstrated good reproducibility (3.8 % RSD) and stability (95 % signal retention after 30 days). In spiked serum samples, recoveries ranged from 96.5 % to 103.2 % with RSDs below 4.5 %. Compared to traditional methods, this biosensor offers improved sensitivity and shorter analysis time for VacA detection, potentially enhancing early diagnosis of H. pylori infections and monitoring treatment efficacy.
{"title":"Detection of H. pylori VacA protein using a graphene-Au nanoparticle electrochemical sensing platform","authors":"Hao Deng, Shangyao Mo, Yong Xie, Rong Chen","doi":"10.1016/j.ijoes.2024.100807","DOIUrl":"10.1016/j.ijoes.2024.100807","url":null,"abstract":"<div><div>This study presents a novel electrochemical biosensor for the detection of Helicobacter pylori VacA protein using a graphene-Au nanocomposite platform. The nanocomposite was synthesized via a one-pot reduction method and characterized using SEM, XRD, and FTIR. The biosensor fabrication process was monitored through cyclic voltammetry and electrochemical impedance spectroscopy. Optimization studies revealed ideal conditions of pH 7.4, 30-minute incubation time, and 100 μg/mL antibody concentration. The biosensor exhibited a linear response range of 0.1–100 ng/mL with a detection limit of 0.03 ng/mL. Selectivity tests against common interfering substances showed minimal cross-reactivity (<5 % signal change). The sensor demonstrated good reproducibility (3.8 % RSD) and stability (95 % signal retention after 30 days). In spiked serum samples, recoveries ranged from 96.5 % to 103.2 % with RSDs below 4.5 %. Compared to traditional methods, this biosensor offers improved sensitivity and shorter analysis time for VacA detection, potentially enhancing early diagnosis of H. pylori infections and monitoring treatment efficacy.</div></div>","PeriodicalId":13872,"journal":{"name":"International Journal of Electrochemical Science","volume":"19 10","pages":"Article 100807"},"PeriodicalIF":1.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01DOI: 10.1016/j.ijoes.2024.100812
N. Chahboun , N. Timoudan , O. Belhoussaine , A. Barrahi , Abhinay Thakur , I. Warad , R. Flouchi , A. Zaroual , F. Benhiba , M. El Faydy , K. Karrouchi , H. Harhar , Hatem A. Abuelizz , A. Zarrouk
This study targeted evaluating the anticorrosive and antioxidative characteristics of Dittrichia viscosa (ZS-OH) extract. ZS-OH was first extracted by deploying a soxhlet and characterized by chromatographic analysis (GC/MS). In addition, a quantitative assessment of the total phenolic (TPC) and flavonoids (FC) content of the ZS-OH extract, as well as phytochemical analyses, were carried out. Antioxidant testing was conducted using the bioassay: 2,2-diphenyl-1-picrylhydrazyl (DPPH). The ability of ZS-OH extract to stymie the corrosion of carbon steel in 1.0 M HCl was considered through potentiodynamic polarization and electrochemical impedance spectroscopy (EIS). ZS-OH extract yield was 4.73 %, and GC-MS revealed 32 distinct chemicals. Neryl isovalerate (29.8 %), 1,10-di-epi-Cubenol (25.4 %), and 2,5-dimethoxy-p-cymene (11.6 %) made up the majority of the ZS-OH extract. The electrochemical results reveal that the ZS-OH extract acts as a mixed-type with an inhibition efficiency of up to 96.8 % at 500 ppm under 303 K. Surface analyses using SEM/EDS confirmed the formation of the protective layer of ZS-OH extract molecules on the C-S surface. The three major components are fully optimized in the DFT through the B3LYP functional and 6–311++G(d,p) basis sets. Molecular dynamics simulation data show the molecules of ZS-OH extract oriented beneficially on metal surfaces, providing a high surface coverage, and thus, a high inhibition performance.
{"title":"Assessment of ethanolic extract of Dittrichia viscosa from Kardoussa Douar region of Taza in Morocco as antioxidant and green inhibitor for carbon steel corrosion in acidic medium","authors":"N. Chahboun , N. Timoudan , O. Belhoussaine , A. Barrahi , Abhinay Thakur , I. Warad , R. Flouchi , A. Zaroual , F. Benhiba , M. El Faydy , K. Karrouchi , H. Harhar , Hatem A. Abuelizz , A. Zarrouk","doi":"10.1016/j.ijoes.2024.100812","DOIUrl":"10.1016/j.ijoes.2024.100812","url":null,"abstract":"<div><div>This study targeted evaluating the anticorrosive and antioxidative characteristics of <em>Dittrichia viscosa</em> (<em>ZS-OH</em>) extract. <em>ZS-OH</em> was first extracted by deploying a soxhlet and characterized by chromatographic analysis (GC/MS). In addition, a quantitative assessment of the total phenolic (TPC) and flavonoids (FC) content of the ZS-OH extract, as well as phytochemical analyses, were carried out. Antioxidant testing was conducted using the bioassay: 2,2-diphenyl-1-picrylhydrazyl (DPPH). The ability of <em>ZS-OH</em> extract to stymie the corrosion of carbon steel in 1.0 M HCl was considered through potentiodynamic polarization and electrochemical impedance spectroscopy (EIS). <em>ZS-OH</em> extract yield was 4.73 %, and GC-MS revealed 32 distinct chemicals. Neryl isovalerate (29.8 %), 1,10-di-epi-Cubenol (25.4 %), and 2,5-dimethoxy-p-cymene (11.6 %) made up the majority of the <em>ZS-OH</em> extract. The electrochemical results reveal that the ZS-OH extract acts as a mixed-type with an inhibition efficiency of up to 96.8 % at 500 ppm under 303 K. Surface analyses using SEM/EDS confirmed the formation of the protective layer of ZS-OH extract molecules on the C-S surface. The three major components are fully optimized in the DFT through the B3LYP functional and 6–311++G(d,p) basis sets. Molecular dynamics simulation data show the molecules of ZS-OH extract oriented beneficially on metal surfaces, providing a high surface coverage, and thus, a high inhibition performance.</div></div>","PeriodicalId":13872,"journal":{"name":"International Journal of Electrochemical Science","volume":"19 10","pages":"Article 100812"},"PeriodicalIF":1.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142421982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01DOI: 10.1016/j.ijoes.2024.100813
Zhenghan Li , Guoping Xue , Yu Mei
This review examines the applications of electrochemical analytical techniques for detecting human epidermal growth factor receptor 2 (HER2) in breast cancer diagnostics. HER2 overexpression occurs in 15–20 % of breast cancers and is associated with aggressive tumor behavior. Accurate HER2 detection is crucial for prognosis and treatment selection. Electrochemical methods offer advantages over traditional techniques, including high sensitivity, rapid analysis, low cost, and potential for miniaturization. The review discusses various electrochemical approaches, focusing on immunosensors and aptamer-based sensors. Immunosensors utilize antibodies as biorecognition elements, often incorporating nanomaterials to enhance performance. Aptasensors employ synthetic oligonucleotides with high affinity and selectivity for HER2. Both sensor types demonstrate detection limits in the pico- to femtomolar range. Other promising approaches include molecularly imprinted polymer-based sensors and electrochemiluminescence methods. Despite significant progress, challenges remain in standardization, long-term stability, and clinical validation. Future developments may involve integrating electrochemical HER2 sensors with point-of-care testing (POCT) platforms, potentially enabling rapid, on-site assessment. Advancements in nanomaterials, surface chemistry, and data analysis techniques offer opportunities to improve sensor performance. As these challenges are addressed, electrochemical HER2 sensors have the potential to complement or replace current testing methods, offering more accessible and efficient HER2 assessment for improved breast cancer management.
{"title":"Applications of electrochemical analytical techniques in HER2 detection for breast cancer","authors":"Zhenghan Li , Guoping Xue , Yu Mei","doi":"10.1016/j.ijoes.2024.100813","DOIUrl":"10.1016/j.ijoes.2024.100813","url":null,"abstract":"<div><div>This review examines the applications of electrochemical analytical techniques for detecting human epidermal growth factor receptor 2 (HER2) in breast cancer diagnostics. HER2 overexpression occurs in 15–20 % of breast cancers and is associated with aggressive tumor behavior. Accurate HER2 detection is crucial for prognosis and treatment selection. Electrochemical methods offer advantages over traditional techniques, including high sensitivity, rapid analysis, low cost, and potential for miniaturization. The review discusses various electrochemical approaches, focusing on immunosensors and aptamer-based sensors. Immunosensors utilize antibodies as biorecognition elements, often incorporating nanomaterials to enhance performance. Aptasensors employ synthetic oligonucleotides with high affinity and selectivity for HER2. Both sensor types demonstrate detection limits in the pico- to femtomolar range. Other promising approaches include molecularly imprinted polymer-based sensors and electrochemiluminescence methods. Despite significant progress, challenges remain in standardization, long-term stability, and clinical validation. Future developments may involve integrating electrochemical HER2 sensors with point-of-care testing (POCT) platforms, potentially enabling rapid, on-site assessment. Advancements in nanomaterials, surface chemistry, and data analysis techniques offer opportunities to improve sensor performance. As these challenges are addressed, electrochemical HER2 sensors have the potential to complement or replace current testing methods, offering more accessible and efficient HER2 assessment for improved breast cancer management.</div></div>","PeriodicalId":13872,"journal":{"name":"International Journal of Electrochemical Science","volume":"19 10","pages":"Article 100813"},"PeriodicalIF":1.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142421443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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