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Evaluation of drug promotional literatures in a tertiary care hospital setting in South India 在南印度三级保健医院设置的药物宣传文献的评价
Pub Date : 2021-04-26 DOI: 10.18203/2319-2003.IJBCP20211648
Ravi H. Kudthni, F. Ahmed, Sangala Srimanth Madanna, Samba Siva Raju Derangula, Pothuru Anil Kumar
Background: The drug promotional literature is one of many sources for seeking information about the drugs to the busy medical practitioner. The aim of current study was to assess drug promotional literatures as per world health organization, criteria and categorize them and to analyse the claims in presented in DPL. Methods: Current study is a descriptive study in which pharmaceutical promotional materials were collected from selected out-patient departments of a tertiary care hospital, Kurnool. Printed drug promotional literatures for modern drugs were collected and an assessment was made whether the advertisements adhered to WHO criteria for medicinal drug promotion. Results: A total of 271 drug promotional literatures were collected. Information about the single drug was given in 127 (46.9%). 144 (53.1%) DPLs contain fixed-dose combination. Majority of drug promoted in collected DPLs were miscellaneous group 83 (30.8%) followed by antimicrobials 55(20.3%) and blood and cardiovascular drugs 37(13.1), gastrointestinal drugs 23(8.5%), drugs acting on endocrine system 23(84.5%). Generic name was mentioned in 229(84.5%) while brand name was mentioned in 271(100%) of DPL. Conclusions: The study concluded that the drug information provided in the promotional brochures can be incomplete and unreliable. Hence a physician should not rely solely on the DPL provided by medical representatives. All brochures circulated among prescribers must undergo a strict process of assessment regarding information provided, especially related to efficacy and safety.
背景:药品宣传文献是忙碌的医生获取药品信息的众多来源之一。本研究的目的是根据世界卫生组织的标准对药品宣传文献进行评估和分类,并对DPL中提出的索赔进行分析。方法:本研究是一项描述性研究,在该研究中,从选定的三级保健医院门诊收集药物宣传材料,库尔努尔。收集现代药品宣传印刷文献,评价广告是否符合世界卫生组织药品宣传标准。结果:共收集到271篇药品宣传文献。127例(46.9%)给出了单药信息。144个(53.1%)dpl包含固定剂量组合。收集到的DPLs中促进药物最多的是杂项类药物83种(30.8%),其次是抗菌素类药物55种(20.3%),其次是血液和心血管类药物37种(13.1%),胃肠道药物23种(8.5%),内分泌系统药物23种(84.5%)。DPL中有229例(84.5%)提到了通用名,271例(100%)提到了品牌名。结论:本研究认为药品宣传手册中提供的药品信息可能不完整且不可靠。因此,医生不应完全依赖医疗代表提供的DPL。处方者之间分发的所有手册必须经过严格的信息评估程序,特别是与疗效和安全性有关的信息。
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引用次数: 1
Intravenous ondansetron induced hypersensitivity reaction: a case report 静脉注射昂丹司琼致超敏反应1例
Pub Date : 2021-04-26 DOI: 10.18203/2319-2003.IJBCP20211657
S. Nitya, M. Shanthi, R. Meenakshi, S. Kiruthika
Ondansetron a selective 5-HT3 receptor antagonist has been widely used as a prophylactic antiemetic for chemotherapy induced and anaesthesia related nausea and vomiting. Anaphylaxis and anaphylactoid reaction rarely occur in less than 1% of the patients and may lead to potentially life-threatening events. This study is one such rare case report of hypersensitivity reaction to intravenous ondansetron in a perioperative setting. Familiarity about anaphylactoid reactions to intravenous ondansetron among the health practitioners would help them to bring about a rational approach to decrease its incidence.
昂丹司琼是一种选择性5-HT3受体拮抗剂,已被广泛用于化疗引起的和麻醉相关的恶心呕吐的预防性止吐药。过敏反应和类过敏反应很少发生在不到1%的患者中,并可能导致潜在的危及生命的事件。这项研究是一个罕见的病例报告过敏反应静脉注射昂丹司琼在围手术期设置。卫生从业人员对静脉注射昂丹司琼类过敏反应的熟悉将有助于他们采取合理的方法来减少其发生率。
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引用次数: 0
Study of price variation analysis of fluoroquinolones eye drops manufactured by various pharmaceutical companies in India 印度各制药公司生产的氟喹诺酮类滴眼液价格变化分析研究
Pub Date : 2021-04-26 DOI: 10.18203/2319-2003.IJBCP20211653
D. Sinha, Bhuwaneshwari Sinha, Santosh Kumar, A. Chandra
Background: Fluoroquinolone eye drops is being prescribed by Opthalmologist in many ocular diseases as conjunctivitis, keratitis, bacterial corneal ulcers etc in more and more amount. There are many brands of fluoroquinolones drugs available in Indian market. Costly drugs can lead to economic burden on patients. Modifications in pharmaceutical policy are required, and prices of the drug should be controlled in effective way for all the drugs. Hence this study was done to assess the cost variation of fluoroquinolones opthalmic solutions available in Indian market. Methods: The maximum and minimum price of each brand of the drug in INR was noted by using CIMS January to April 2020 edition and Drug Today April to June 2020 volume 1. The cost ratio and the percentage cost variation for individual drug brands was calculated. The cost of each eye drop was calculated. At last the cost ratio and percentage cost variation of various brands was compared. Results: Percentage variation in cost for fluoroquinolones eye preparations marketed in India was found to be Eye drop Ciprofloxacin (0.3%) of 5 ml:210.39, Eye drop Ciprofloxacin (0.3%) of 10 ml:162, Eye drop Gatifloxacin (0.3%) of 5 ml:156, Eye drop Moxifloxacin (0.5%) of 5 ml:196.95, Eye drop Ofloxacin (0.3%) of 5 ml:245.16, Eye drop Ofloxacin (0.3%) of 10 ml:62.5, Eye drop Norfloxacin (0.3%) of 5 ml:120.68, Eye drop Sparfloxacin (0.3%):8.31, Eye drop Lomefloxacin (0.3%):16.17. Conclusions: There is a wide difference in the cost of different brands of fluoroquinolones eye preparations available in India. The clinicians prescribing these drugs should be aware of these variations in cost to reduce the cost of drug therapy.
背景:氟喹诺酮类滴眼液在结膜炎、角膜炎、细菌性角膜溃疡等眼病中的应用越来越广泛。印度市场上有许多品牌的氟喹诺酮类药物。昂贵的药物会给病人带来经济负担。需要修改药品政策,对所有药品实行有效的价格控制。因此,本研究旨在评估印度市场上可获得的氟喹诺酮类眼科溶液的成本变化。方法:采用CIMS 2020年1 - 4月版和《今日药品》2020年4 - 6月卷1,记录各品牌药品INR最高、最低价格。计算各药品品牌的成本比和成本变动百分比。计算每滴眼液的成本。最后比较了各品牌的成本比和成本变动百分比。结果:氟喹诺酮类眼药在印度市场的价格变动百分比为:环丙沙星滴眼液(0.3%)为5 ml:210.39,环丙沙星滴眼液(0.3%)为10 ml:162,加替沙星滴眼液(0.3%)为5 ml:156,莫西沙星滴眼液(0.5%)为5 ml:196.95,氧氟沙星滴眼液(0.3%)为5 ml:245.16,氧氟沙星滴眼液(0.3%)为10 ml:62.5,诺氟沙星滴眼液(0.3%)为5 ml:120.68,斯帕沙星滴眼液(0.3%):8.31,洛美沙星滴眼液(0.3%):16.17。结论:在印度,不同品牌的氟喹诺酮类眼科制剂的价格差异很大。处方这些药物的临床医生应该意识到这些成本的变化,以减少药物治疗的成本。
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引用次数: 0
Fixed drug eruption associated with fixed combination of fluoroquinolone-nitroimidazole 氟喹诺酮-硝基咪唑固定联合用药伴固定药疹
Pub Date : 2021-04-26 DOI: 10.18203/2319-2003.IJBCP20211656
R. Meenakshi, S. Nitya, S. Kiruthika, M. Shanthi
Fixed drug eruptions (FDE) are cutaneous adverse drug reaction characterized by well demarcated erythematous plaques which on removal of the offending agent resolves with residual hyperpigmentation patches at the site. FDE to nitroimidazoles and fluoroquinolones have nevertheless been infrequently reported. Awareness about the adverse reaction to the fluoroquinolone-nitroimidazole combination drug and also the likelihood of recurrence with same or similar drugs and the possible cross reaction is eminent. Hereby we report one such case of FDE to ciprofloxacin/tinidazole combination.
固定药物疹(FDE)是一种皮肤药物不良反应,其特征是界限清晰的红斑斑块,在清除病原体后,该斑块会在该部位残留色素沉着斑块。然而,对硝基咪唑和氟喹诺酮类药物的FDE很少报道。对氟喹诺酮-硝基咪唑联合用药的不良反应、与相同或类似药物复发的可能性以及可能的交叉反应的认识是显著的。在此,我们报告一例因环丙沙星/替硝唑联合用药而导致的FDE。
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引用次数: 0
A rational pharmacotherapeutic study of the prevalent prescription patterns of delamanid, ofloxacin, levofloxacin, and bedaquiline among the multi-drug resistant tuberculosis patients in global multi-centre tertiary care hospitals 全球多中心三级医院耐多药结核病患者德拉马尼、氧氟沙星、左氧氟沙星和贝达喹啉流行处方模式的合理药物治疗研究
Pub Date : 2021-04-26 DOI: 10.18203/2319-2003.IJBCP20211649
Moumita Hazra
Background: Delamanid, a nitro-dihydro-imidazooxazole, is a bactericidal cell wall methoxy-mycolic and ketomycolic acids biosynthesis inhibitor in actively replicating, dormant, and intracellular tuberculosis, and both drugsusceptible and drug-resistant strains of M. tuberculosis and M. kansasii, decreasing hydrophobicity and facilitating better bacterial drug penetration. Delamanid promotes intracellular generation of microbiocidal nitrogen oxidative intermediaries including nitric oxide, toxic even to dormant M. tuberculosis. Ofloxacin, the racemic mixture and levofloxacin, the S-or levorotatory isomer of ofloxacin, are bactericidal to M. tuberculosis, MAC, M. fortuitum, and other atypical mycobacteria, with inhibitory effect on DNA gyrase, DNA topoisomerase IV and IL-1α, IL-6, IL-8. Bedaquiline, a novel diarylquinoline, inhibits mycobacterial adenosine triphosphate synthase of M. tuberculosis, disrupting mycobacterial energy metabolism and replication. Bedaquiline’s initial bacteriostatic action is followed by a bactericidal effect after 5-7 days. The objective was to perform a rational pharmacotherapeutic study of the prevalent prescription patterns of delamanid, ofloxacin, levofloxacin, and bedaquiline, among the multi-drug resistant tuberculosis patients, in global multi-centre tertiary care hospitals. Methods: A multi-centre, retrospective, observational and analytical study of clinical prescriptions of 100 multi-drug resistant tuberculosis patients in hospitals, were performed. For 24-48 weeks, these patients had been prescribed antitubercular drugs, like delamanid 100 mg and ofloxacin 400 mg twice daily, levofloxacin 750 mg and bedaquiline 400 mg once daily followed by 200 mg thrice weekly, as part of MDR-TB treatment regimens. The no. of prescriptions for each drug were recorded, and the corresponding prescription rates were statistically derived in percentages. Results: Delamanid was most commonly prescribed (32 prescriptions, 32%), followed by ofloxacin (29 prescriptions, 29%), levofloxacin (24 prescriptions, 24%), and bedaquiline (15 prescriptions, 15%). The completeness of the prescription contents, the dose of drug, the duration of treatment, the instructions of medication, the frequency of drug intake, the name of the drug and the dosage form of the drug were observed in 100% of prescriptions. Conclusions: Prescription frequency of delamanid was followed by ofloxacin, levofloxacin and bedaquiline. Prescription content analyses showed 100% completeness.
背景:Delamanid是一种硝基二氢咪唑唑类抗菌细胞壁甲氧基霉菌酸和酮酵母酸生物合成抑制剂,对结核分枝杆菌和堪萨斯分枝杆菌的活性复制、休眠和细胞内结核以及药敏和耐药菌株均有抑制作用,可降低疏水性,促进细菌更好地渗透药物。Delamanid促进细胞内产生杀灭微生物的氮氧化中间体,包括一氧化氮,甚至对休眠的结核分枝杆菌有毒。氧氟沙星外消旋混合物与氧氟沙星s或左旋异构体左氧氟沙星对结核分枝杆菌、MAC、福氏分枝杆菌等非典型分枝杆菌均有杀菌作用,对DNA旋切酶、DNA拓扑异构酶IV及IL-1α、IL-6、IL-8均有抑制作用。贝达喹啉是一种新型的二芳基喹啉,抑制结核分枝杆菌三磷酸腺苷合成酶,破坏分枝杆菌的能量代谢和复制。贝达喹啉最初的抑菌作用在5-7天后产生杀菌作用。目的是对全球多中心三级保健医院多重耐药结核病患者中delamanid、氧氟沙星、左氧氟沙星和贝达喹啉的普遍处方模式进行合理的药物治疗研究。方法:对我院100例耐多药结核病患者的临床处方进行多中心回顾性、观察性和分析性研究。在24-48周的时间里,这些患者服用了抗结核药物,如delamanid 100毫克,氧氟沙星400毫克,每天两次,左氧氟沙星750毫克,贝达喹啉400毫克,每天一次,随后每周服用200毫克,每周服用三次,作为耐多药结核病治疗方案的一部分。没有。记录每种药物的处方数,并以百分比统计得出相应的处方率。结果:处方最多的是德拉马尼(32张,占32%),其次是氧氟沙星(29张,占29%)、左氧氟沙星(24张,占24%)和贝达喹啉(15张,占15%)。100%的处方内容、用药剂量、疗程、用药说明、用药频次、药品名称、剂型的填写是否完整。结论:德拉马尼处方频次次之为氧氟沙星、左氧氟沙星、贝达喹啉。处方含量分析100%完整。
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引用次数: 0
Polymicrobial therapy induced nephrotoxicity: more is not always better 多微生物治疗引起的肾毒性:越多并不总是越好
Pub Date : 2021-04-26 DOI: 10.18203/2319-2003.IJBCP20211655
Ankit R. Mistry, Sapna Gupta, S. Malhotra
Polymicrobial induced nephrotoxicity (PIN) occurs more commonly in critically ill patients. Exposure to drugs often results in toxicity in kidney which represents a major control system maintaining homeostasis of body and thus is especially susceptible to xenobiotics. We present here an adverse drug reaction which is additive nephrotoxicity with combined antimicrobial use in critically ill patient. Blood urea and serum creatinine levels were raised much above the baseline after a fortnight of therapy. The suspected drugs were withdrawn leading to a gradual improvement and normalization of blood urea and serum creatinine levels This suggested a causal relationship which was possibly due to the administration of nephrotoxic antimicrobials. The present case highlights that critically ill patients on prolonged Polymicrobial therapy should be closely monitored, and dose increments should be made cautiously.
多微生物引起的肾毒性(PIN)更常见于危重患者。肾脏是维持机体内稳态的主要控制系统,因此对外源性药物特别敏感,因此暴露于药物往往会导致肾脏中毒。我们在这里提出一个药物不良反应,这是加性肾毒性联合抗菌素使用危重病人。治疗两周后,血尿素和血清肌酐水平明显高于基线。停用疑似药物后,患者的尿素和血清肌酐水平逐渐改善并恢复正常。这表明可能与肾毒性抗菌剂的使用有关。本病例强调,应密切监测长期多微生物治疗的危重患者,并谨慎增加剂量。
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引用次数: 0
Licofelone in osteoarthritis: is this the awaited drug? a systematic review 利可菲龙治疗骨关节炎:这是期待已久的药物吗?系统回顾
Pub Date : 2021-04-26 DOI: 10.18203/2319-2003.IJBCP20211654
V. P.
Licofelone in osteoarthritis: is this the awaited drug? a systematic review - Osteoarthritis is a progressive joint disease
利可菲龙治疗骨关节炎:这是期待已久的药物吗?系统综述-骨关节炎是一种进行性关节疾病
{"title":"Licofelone in osteoarthritis: is this the awaited drug? a systematic review","authors":"V. P.","doi":"10.18203/2319-2003.IJBCP20211654","DOIUrl":"https://doi.org/10.18203/2319-2003.IJBCP20211654","url":null,"abstract":"Licofelone in osteoarthritis: is this the awaited drug? a systematic review - Osteoarthritis is a progressive joint disease","PeriodicalId":13898,"journal":{"name":"International journal of basic and clinical pharmacology","volume":"35 1","pages":"564"},"PeriodicalIF":0.0,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88880459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
COVID-19 vaccines: the dilemma when thinking as a patient COVID-19疫苗:作为患者思考时的困境
Pub Date : 2021-04-26 DOI: 10.18203/2319-2003.IJBCP20211662
S. Sharif, Rubian S Sharif
What is the truth about the conspiracy theory of the COVID-19 microchip vaccine? The outbreak of the COVID-19 witnessed a vicious race of pharmaceutical firms to develop a vaccine that ends this disaster. Claims were forwarded that some firms funded by well-known foundations are in the process of developing such a vaccine so people wide world can be tracked. Such claims may have been based on Mr. Bill Gate’s announcement in an interview that through vaccination "we will have some digital certificates" which would be used to show who had recovered, been tested and ultimately who received a vaccine but he made no mention of microchips.  The conspiracy theory is spreading around the world and its supporters are on the increase among the public as well as many healthcare professionals. The spread of the virus has been attributed to the introduction of 5G technology and many religious leaders attributed the crisis to punishment from God to the spread of local wars and mass killing, torturing and killing of Muslims in China and Myanmar gay and lesbian movement and marriages.
“新型冠状病毒微芯片疫苗阴谋论”的真相是什么?新型冠状病毒感染症(COVID-19)爆发后,制药公司为了开发能够结束这场灾难的疫苗展开了恶性竞争。有人声称,一些由知名基金会资助的公司正在开发这种疫苗,以便追踪世界各地的人。这种说法可能是基于比尔·盖茨先生在一次采访中宣布,通过接种疫苗,“我们将获得一些数字证书”,用于显示谁已经康复,接受了测试,并最终接种了疫苗,但他没有提到微芯片。阴谋论正在世界各地传播,其支持者在公众和许多医疗保健专业人员中越来越多。病毒的传播被归因于5G技术的引入,许多宗教领袖将危机归因于上帝的惩罚,局部战争的蔓延和大规模屠杀,折磨和杀害穆斯林在中国和缅甸的同性恋运动和婚姻。
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引用次数: 0
Pre COVID-19 usage of smartphones and medical applications among medical students 新冠肺炎前医学生智能手机和医疗应用的使用情况
Pub Date : 2021-04-26 DOI: 10.18203/2319-2003.IJBCP20211639
H. A. Butt, W. Ali, Warda Hussain, Amaidah Mir, W. Butt, Manahil Zulfiqar
Background: To determine awareness of medical students that utilize smartphone and their familiarity of medical applications. Methods: The questionnaire-based descriptive study was conducted in December 2019 and comprised medical students of first year and second year of the CMH Kharian Medical College, Kharian, and Nawaz Sharif Medical College, Gujrat, Gujranwala Medical College, Gujranwala and Mohi-ud-Din Islamic Medical College, Mirpur. Questionnaires were distributed in the classrooms and were filled by the students anonymously. SPSS 20 was used for statistical analysis. Results: Among the 770 medical students in the study, 747 (97%) had smartphones and 23 (3%) were using simple cell phones. Overall, 362 (47%) of the smart phone users were using some medical apps. Besides, 223 (29%) were aware of the medical apps but were not using them. Also, 655 (85%) students were not using any type of medical text eBooks through their phone, and only 115 (15%) had relevant text eBooks in their phones. Conclusions: A very low awareness among medical college students exists regarding smartphones as a gadget for improving medical knowledge.
背景:确定医学生使用智能手机的意识和他们对医学应用的熟悉程度。方法:于2019年12月进行基于问卷的描述性研究,研究对象为古吉拉特邦CMH Kharian医学院、Nawaz Sharif医学院、Gujranwala医学院、Gujranwala医学院和Mirpur mohi - oud - din伊斯兰医学院的一年级和二年级医学生。调查问卷在教室里分发,由学生匿名填写。采用SPSS 20进行统计分析。结果:参与研究的770名医学生中,有747名(97%)拥有智能手机,23名(3%)使用简易手机。总体而言,362(47%)的智能手机用户在使用一些医疗应用程序。此外,223人(29%)知道医疗应用程序,但没有使用它们。此外,655名(85%)学生没有通过手机使用任何类型的医学文本电子书,只有115名(15%)学生的手机中有相关的文本电子书。结论:医科大学生对智能手机作为提高医学知识的工具的认知程度很低。
{"title":"Pre COVID-19 usage of smartphones and medical applications among medical students","authors":"H. A. Butt, W. Ali, Warda Hussain, Amaidah Mir, W. Butt, Manahil Zulfiqar","doi":"10.18203/2319-2003.IJBCP20211639","DOIUrl":"https://doi.org/10.18203/2319-2003.IJBCP20211639","url":null,"abstract":"Background: To determine awareness of medical students that utilize smartphone and their familiarity of medical applications. Methods: The questionnaire-based descriptive study was conducted in December 2019 and comprised medical students of first year and second year of the CMH Kharian Medical College, Kharian, and Nawaz Sharif Medical College, Gujrat, Gujranwala Medical College, Gujranwala and Mohi-ud-Din Islamic Medical College, Mirpur. Questionnaires were distributed in the classrooms and were filled by the students anonymously. SPSS 20 was used for statistical analysis. Results: Among the 770 medical students in the study, 747 (97%) had smartphones and 23 (3%) were using simple cell phones. Overall, 362 (47%) of the smart phone users were using some medical apps. Besides, 223 (29%) were aware of the medical apps but were not using them. Also, 655 (85%) students were not using any type of medical text eBooks through their phone, and only 115 (15%) had relevant text eBooks in their phones. Conclusions: A very low awareness among medical college students exists regarding smartphones as a gadget for improving medical knowledge.","PeriodicalId":13898,"journal":{"name":"International journal of basic and clinical pharmacology","volume":"11 1","pages":"479"},"PeriodicalIF":0.0,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76243221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbiological profile and antibiotic resistance pattern of urinary tract infection in a tertiary care hospital 某三级医院尿路感染的微生物学特征及抗生素耐药模式
Pub Date : 2021-04-26 DOI: 10.18203/2319-2003.IJBCP20211663
V. R. Vismaya, Naiema Shajihan, M. Ramesh, Ambika Devi
Urinary tract infection (UTI), of varying severity is one of the most commonly encountered ailments in nephrology outpatient department (OPD). The commonest pathogens causing community acquired UTI (CAUTI) are E. Coli, Proteus mirabilis, Pseudomonas aeruginosa and Klebsiella pneumonia. There is a rapidly rising trend of antibiotic resistance among these uropathogens, may be due to indiscriminate antibiotic usage and poor patient compliance. We conducted a retrospective analysis of all culture proven UTI cases that attended the nephrology OPD of S. K. hospital, Trivandrum from August 2017 to July 2019 (24 months). 130 males and 121 females were included in the study. The mean age of the study group was 62.8 years with a male predominance in the age group above 50 years and a female predisposition in less than 50 years group. Commonest pathogen isolated in urine culture was E. coli (52.98%) followed by Klebsiella (39.09%), Citrobacter (8.76%), Pseudomonas (8.37%), Enterobacter (2.39%), Enterococci (1.99%), Candida (1.59%), Acinetobacter (1.2%), Proteus (1.2%), Streptococci (1.2%) and Serratia (0.4%).
尿路感染(UTI),不同的严重程度是肾脏病门诊部(OPD)最常见的疾病之一。引起社区获得性尿路感染(CAUTI)的最常见病原体是大肠杆菌、奇异变形杆菌、铜绿假单胞菌和肺炎克雷伯菌。这些尿路病原体中抗生素耐药性呈快速上升趋势,可能是由于滥用抗生素和患者依从性差。我们对2017年8月至2019年7月(24个月)在特里凡得琅s.k.医院肾病科就诊的所有经培养证实的尿路感染病例进行了回顾性分析。130名男性和121名女性参与了这项研究。研究组平均年龄为62.8岁,50岁以上年龄组以男性为主,50岁以下年龄组以女性为主。尿培养中最常见的病原菌为大肠杆菌(52.98%)、克雷伯氏菌(39.09%)、柠檬酸杆菌(8.76%)、假单胞菌(8.37%)、肠杆菌(2.39%)、肠球菌(1.99%)、念珠菌(1.59%)、不动杆菌(1.2%)、变形杆菌(1.2%)、链球菌(1.2%)和沙雷氏菌(0.4%)。
{"title":"Microbiological profile and antibiotic resistance pattern of urinary tract infection in a tertiary care hospital","authors":"V. R. Vismaya, Naiema Shajihan, M. Ramesh, Ambika Devi","doi":"10.18203/2319-2003.IJBCP20211663","DOIUrl":"https://doi.org/10.18203/2319-2003.IJBCP20211663","url":null,"abstract":"Urinary tract infection (UTI), of varying severity is one of the most commonly encountered ailments in nephrology outpatient department (OPD). The commonest pathogens causing community acquired UTI (CAUTI) are E. Coli, Proteus mirabilis, Pseudomonas aeruginosa and Klebsiella pneumonia. There is a rapidly rising trend of antibiotic resistance among these uropathogens, may be due to indiscriminate antibiotic usage and poor patient compliance. We conducted a retrospective analysis of all culture proven UTI cases that attended the nephrology OPD of S. K. hospital, Trivandrum from August 2017 to July 2019 (24 months). 130 males and 121 females were included in the study. The mean age of the study group was 62.8 years with a male predominance in the age group above 50 years and a female predisposition in less than 50 years group. Commonest pathogen isolated in urine culture was E. coli (52.98%) followed by Klebsiella (39.09%), Citrobacter (8.76%), Pseudomonas (8.37%), Enterobacter (2.39%), Enterococci (1.99%), Candida (1.59%), Acinetobacter (1.2%), Proteus (1.2%), Streptococci (1.2%) and Serratia (0.4%).","PeriodicalId":13898,"journal":{"name":"International journal of basic and clinical pharmacology","volume":"51 1","pages":"611"},"PeriodicalIF":0.0,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85224765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
International journal of basic and clinical pharmacology
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