Background: Microneedling a newer treatment modality for facial acne scars induces collagen production through mechanical stimulation of the dermis and leads to the softening of scars, realignment of collagen bundles and stimulation of new collagen. Topical vitamin C have beneficial effect on acne and improves acne scarring when used in conjunction with glycolic acid peels and post-laser resurfacing. Aims: Split face comparative assessment of the efficacy of microneedling therapy versus microneedling therapy in conjunction with topical vitamin C in facial acne scars. Materials and Methods: This study was performed on 50 patients having facial acne scars after taking informed written consent. The face was divided into right and left half from midline. On the half of face only microneedling and on other side of face microneedling therapy with topical vitamin C (5% L-ascorbic acid) has been used. A total of three session at 4 weeks interval was done in each patient. Facial scars was assessed clinically to grade the severity of scarring, as per the ECCA grading system. Results: Gradual improvement in global score & acne scar types after each sitting of Microneedling as well as Microneedling + Topical Vitamin-C observed. Overall mean percentage improvement with Microneedling + Topical Vitamin-C was more than the mean percentage improvement with Microneedling alone. Conclusion: Microneedling shows significant clinical improvement in the M type scars (rolling), and U type scars (boxcar) and modest improvement in V type scars (ice-pick). Effect of microneedling is enhanced by combining the procedure with application of topical vitamin C.
背景:微针是面部痤疮疤痕的一种较新的治疗方式，通过对真皮层的机械刺激诱导胶原蛋白的产生，导致疤痕的软化，胶原蛋白束的重新排列和新胶原蛋白的刺激。局部维生素C对痤疮有有益的作用，当与乙醇酸换肤和激光后换肤一起使用时，可以改善痤疮疤痕。目的:比较评价微针疗法与微针疗法联合局部维生素C治疗面部痤疮疤痕的疗效。材料与方法:本研究选取50例面部痤疮疤痕患者，经知情书面同意后进行。脸从中线开始分为左右两半。半脸微针治疗，另一侧微针治疗用局部维生素C (5% l -抗坏血酸)。每例患者共进行3次治疗，间隔4周。根据ECCA分级系统，对面部疤痕进行临床评估，以评定疤痕的严重程度。结果:微针每次坐位及微针+局部维生素c后，整体评分及痤疮疤痕类型逐渐改善。微针治疗+外用维生素c治疗的总体平均改善百分比高于单独微针治疗的平均改善百分比。结论:微针治疗M型瘢痕(滚动型)、U型瘢痕(箱型)疗效显著，对V型瘢痕(冰锥型)疗效温和。微针与局部维生素C的应用相结合，可以增强微针的效果。
{"title":"Split face comparative study for efficacy of microneedling alone versus microneedling combined with vitamin c in treating facial acne scars","authors":"R. Chakrawarty, M. Jaiswal","doi":"10.7439/IJBR.V8I11.4445","DOIUrl":"https://doi.org/10.7439/IJBR.V8I11.4445","url":null,"abstract":"Background: Microneedling a newer treatment modality for facial acne scars induces collagen production through mechanical stimulation of the dermis and leads to the softening of scars, realignment of collagen bundles and stimulation of new collagen. Topical vitamin C have beneficial effect on acne and improves acne scarring when used in conjunction with glycolic acid peels and post-laser resurfacing. Aims: Split face comparative assessment of the efficacy of microneedling therapy versus microneedling therapy in conjunction with topical vitamin C in facial acne scars. Materials and Methods: This study was performed on 50 patients having facial acne scars after taking informed written consent. The face was divided into right and left half from midline. On the half of face only microneedling and on other side of face microneedling therapy with topical vitamin C (5% L-ascorbic acid) has been used. A total of three session at 4 weeks interval was done in each patient. Facial scars was assessed clinically to grade the severity of scarring, as per the ECCA grading system. Results: Gradual improvement in global score & acne scar types after each sitting of Microneedling as well as Microneedling + Topical Vitamin-C observed. Overall mean percentage improvement with Microneedling + Topical Vitamin-C was more than the mean percentage improvement with Microneedling alone. Conclusion: Microneedling shows significant clinical improvement in the M type scars (rolling), and U type scars (boxcar) and modest improvement in V type scars (ice-pick). Effect of microneedling is enhanced by combining the procedure with application of topical vitamin C.","PeriodicalId":13909,"journal":{"name":"International journal of biomedical research","volume":"21 1","pages":"598-604"},"PeriodicalIF":0.0,"publicationDate":"2017-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84588543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A large pericardial mass compressing lower trachea and main bronchi was diagnosed in 1 month old baby who presented with dyspnea and cough. Anticipating potential danger of airway collapse during general anaesthesia management of such patient is discussed. Cardiopulmonary bypass was kept ready. Large mass from right side of pericardium was removed. Child recovered uneventfully.
{"title":"Role of Anaesthesiologist in the management of Pericardial Mass in one month old child","authors":"L. Vali, Apeksha A Bhure","doi":"10.7439/IJBR.V8I11.4505","DOIUrl":"https://doi.org/10.7439/IJBR.V8I11.4505","url":null,"abstract":"A large pericardial mass compressing lower trachea and main bronchi was diagnosed in 1 month old baby who presented with dyspnea and cough. Anticipating potential danger of airway collapse during general anaesthesia management of such patient is discussed. Cardiopulmonary bypass was kept ready. Large mass from right side of pericardium was removed. Child recovered uneventfully.","PeriodicalId":13909,"journal":{"name":"International journal of biomedical research","volume":"22 1","pages":"654-656"},"PeriodicalIF":0.0,"publicationDate":"2017-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73001545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Snehal F. Jumnake, Jayawant Mahadhani, Sanjay Khandekar, Nilima D. Lodha, S. Hingway
Background: Infections caused by the hepatitis B virus (HBV) and hepatitis C virus (HCV) are global public health problems. The safety of donated blood can be estimated by monitoring the prevalence of viral markers in the donor population. The present study was carried out in Yavatmal region of Maharashtra state, with an objective to determine the prevalence of HBV and HCV among blood bank donors. Methods: Over a period of three years (January 2014 to December 2016), a total of 33082 blood units were collected from healthy voluntary and replacement blood donors. The donated units were serologically screened for hepatitis B surface antigen (HBsAg) and antibody to hepatitis C virus (anti-HCV). Results: Out of total blood donors, 93.67% were males and 6.32% were females. HBsAg was positive in 284 (0.85%) of the blood units that were collected, the blood units with antiHCV seropositivity had the lowest prevalence (n=9, 0.027%) and these prevalence being higher in males than females. The prevalence of HBsAg was highest in the year of 2015 (0.93%) compared to 2014 (0.85) and 2016 (0.78). There was decline in the prevalence of HCV infection has been observed, from 0.039% in 2014 to 0.016% in 2016. Conclusion: The study reveals that the decrease in HBV and HCV prevalence among blood bank donors in SVNGMC Yavatmal might be associated with the introduction of immunization programs, and an increased awareness of hepatitis B throughout the country.
{"title":"Prevalence of Hepatitis B and C in Blood Bank Donors in SVNGMC Yavatamal","authors":"Snehal F. Jumnake, Jayawant Mahadhani, Sanjay Khandekar, Nilima D. Lodha, S. Hingway","doi":"10.7439/IJBR.V8I11.4494","DOIUrl":"https://doi.org/10.7439/IJBR.V8I11.4494","url":null,"abstract":"Background: Infections caused by the hepatitis B virus (HBV) and hepatitis C virus (HCV) are global public health problems. The safety of donated blood can be estimated by monitoring the prevalence of viral markers in the donor population. The present study was carried out in Yavatmal region of Maharashtra state, with an objective to determine the prevalence of HBV and HCV among blood bank donors. Methods: Over a period of three years (January 2014 to December 2016), a total of 33082 blood units were collected from healthy voluntary and replacement blood donors. The donated units were serologically screened for hepatitis B surface antigen (HBsAg) and antibody to hepatitis C virus (anti-HCV). Results: Out of total blood donors, 93.67% were males and 6.32% were females. HBsAg was positive in 284 (0.85%) of the blood units that were collected, the blood units with antiHCV seropositivity had the lowest prevalence (n=9, 0.027%) and these prevalence being higher in males than females. The prevalence of HBsAg was highest in the year of 2015 (0.93%) compared to 2014 (0.85) and 2016 (0.78). There was decline in the prevalence of HCV infection has been observed, from 0.039% in 2014 to 0.016% in 2016. Conclusion: The study reveals that the decrease in HBV and HCV prevalence among blood bank donors in SVNGMC Yavatmal might be associated with the introduction of immunization programs, and an increased awareness of hepatitis B throughout the country.","PeriodicalId":13909,"journal":{"name":"International journal of biomedical research","volume":"193 1","pages":"646-650"},"PeriodicalIF":0.0,"publicationDate":"2017-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79426886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: The serum phosphorus level is recently considered as one of the foretelling markers for the severity of cardiovascular diseases. Therefore, this study is aimed to investigate whether the serum phosphorus level in myocardial infarction patients with normal kidney function against healthy individuals could act as a possible marker for identification of vulnerability in cardiovascular diseases. Method: This is observational case control study of 70 controls and 70 patients who were admitted in ICCU of S.S.G. Hospital, Baroda. Routine parameters, serum Phosphorus & lipid profile, CKMB levels were performed.Result: Serum Phosphorus, S. HDL and S. LDL showing significant correlation (p-value <0.0001). The study correlates well with the increase in Serum Phosphorus level with decrease in S.HDL and increase in S.LDL.Conclusion: Serum phosphorus level might be used as similar to lipid profile and/or other risk factors alteration. The serum phosphorus level is recently being considered as one of the foretelling markers for the severity of cardiovascular diseases because of its role in vascular calcification and oxidative stress.
{"title":"Serum Phosphorus level: A marker of myocardial infarction.","authors":"Neha D. Sheth, H. Sirajwala","doi":"10.7439/IJBR.V8I11.4450","DOIUrl":"https://doi.org/10.7439/IJBR.V8I11.4450","url":null,"abstract":"Introduction: The serum phosphorus level is recently considered as one of the foretelling markers for the severity of cardiovascular diseases. Therefore, this study is aimed to investigate whether the serum phosphorus level in myocardial infarction patients with normal kidney function against healthy individuals could act as a possible marker for identification of vulnerability in cardiovascular diseases. Method: This is observational case control study of 70 controls and 70 patients who were admitted in ICCU of S.S.G. Hospital, Baroda. Routine parameters, serum Phosphorus & lipid profile, CKMB levels were performed.Result: Serum Phosphorus, S. HDL and S. LDL showing significant correlation (p-value <0.0001). The study correlates well with the increase in Serum Phosphorus level with decrease in S.HDL and increase in S.LDL.Conclusion: Serum phosphorus level might be used as similar to lipid profile and/or other risk factors alteration. The serum phosphorus level is recently being considered as one of the foretelling markers for the severity of cardiovascular diseases because of its role in vascular calcification and oxidative stress.","PeriodicalId":13909,"journal":{"name":"International journal of biomedical research","volume":"127 1","pages":"618-622"},"PeriodicalIF":0.0,"publicationDate":"2017-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78879832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective : Like overt cases, whether subclinical hypothyroidism also causes supressed neuronal transmission is still debated . In this study, we tried to explore whether neuronal transmission is impaired in peripheral nerves in subclinical hypothyroidism with the help of Nerve Conduction Studies. Methods: 30 subclinical hypothyroid cases and 30 age sex matched euthyroid control were examined. All the subjects were assessed for Nerve Conduction velocity (NCV).Latency ,amplitude of CMAP(Compound Motor Action Potential) and conduction velocity of peripheral nerves like median and ulnar of both hands were considered. Findings were compared between groups by unpaired Students T- test andassociation among thyroid function parameters and NCV findings were tested by Pearsons co efficient of correlation (r value). Every where p< 0.05 was considered as significant. Results: Subclinical hypothyroids showed significantly higher distal latencies but lower conduction velocities of both median and ulnar nerves than the euthyroid controls (p<0.05 in each case). Amplitude of CMAP of both the nerves were not significantly different between the groups.Level of T3 was found to have a significant negative correlation withdistal latencies of Median and ulnar nerves (r value = -0.51 and -0.38 respectively, P<0.05 in each case) whereas a positive correlation with their conduction velocities (r- value = 0.27 and 0.55 respectively, p< 0.05 in each case). TSH however did not show any significant correlation with NCV parameters. Conclusion: Subclinical hypothyroidism may cause impairment in peripheral nerve conduction but the severity of such neurodeficit is not correlated with the level of TSH but with the level of T3.
{"title":"Assessment of peripheral neuronal activity with Nerve Conduction Studies in subclinical hypothyroidfemales from rural area of Bankura district of West Bengal","authors":"Piyali Das, P. Pradhan, Sharmistha Ghoshal","doi":"10.7439/IJBR.V8I11.4454","DOIUrl":"https://doi.org/10.7439/IJBR.V8I11.4454","url":null,"abstract":"Objective : Like overt cases, whether subclinical hypothyroidism also causes supressed neuronal transmission is still debated . In this study, we tried to explore whether neuronal transmission is impaired in peripheral nerves in subclinical hypothyroidism with the help of Nerve Conduction Studies. Methods: 30 subclinical hypothyroid cases and 30 age sex matched euthyroid control were examined. All the subjects were assessed for Nerve Conduction velocity (NCV).Latency ,amplitude of CMAP(Compound Motor Action Potential) and conduction velocity of peripheral nerves like median and ulnar of both hands were considered. Findings were compared between groups by unpaired Students T- test andassociation among thyroid function parameters and NCV findings were tested by Pearsons co efficient of correlation (r value). Every where p< 0.05 was considered as significant. Results: Subclinical hypothyroids showed significantly higher distal latencies but lower conduction velocities of both median and ulnar nerves than the euthyroid controls (p<0.05 in each case). Amplitude of CMAP of both the nerves were not significantly different between the groups.Level of T3 was found to have a significant negative correlation withdistal latencies of Median and ulnar nerves (r value = -0.51 and -0.38 respectively, P<0.05 in each case) whereas a positive correlation with their conduction velocities (r- value = 0.27 and 0.55 respectively, p< 0.05 in each case). TSH however did not show any significant correlation with NCV parameters. Conclusion: Subclinical hypothyroidism may cause impairment in peripheral nerve conduction but the severity of such neurodeficit is not correlated with the level of TSH but with the level of T3.","PeriodicalId":13909,"journal":{"name":"International journal of biomedical research","volume":"15 1","pages":"605-608"},"PeriodicalIF":0.0,"publicationDate":"2017-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75119944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims and Objectives: The present study was undertaken to compare the onset time, duration of action of sensory and motor blockade and postoperative pain relief between 0.25% bupivacaine and 0.25% ropivacaine in caudal block for children undergoing lower abdominal surgeries. Method: In a double blind study, 50 patients of (age 2-8 years) ASA grade I and II were randomly allocated in two equal groups to received 0.75ml/ kg of either 0.25% bupivacaine (Group I) or 0.25% ropivacaine (Group II) via caudal epidural route. Caudal block was performed in all patients after induction of anesthesia with sevoflurane and oxygen. All the results were tabulated and analyzed statistically. For all statistical analysis, the level of significance was P 0.05). The duration of motor block in group I was 142.227.77 minutes while in group II it was 120.623.51 minutes (p 0.05). The mean pain score of patients in both groups were comparable. Conclusion: Bupivacaine and Ropivacaine provides almost similar duration of pain relief postoperatively but ropivacaine provides less motor blockade as compared to bupivacaine, making it a suitable agent for day care surgery with increase safety margin particularly in younger children.
目的和目的:本研究比较0.25%布比卡因和0.25%罗哌卡因在儿童下腹部手术尾侧阻滞中的起效时间、感觉和运动阻断的作用时间以及术后疼痛缓解。方法:采用双盲方法，将50例(2-8岁)ASA I级和II级患者随机分为两组，经尾侧硬膜外注射0.75ml/ kg 0.25%布比卡因(I组)或0.25%罗哌卡因(II组)。所有患者在七氟醚加氧诱导麻醉后均行尾侧阻滞。将所有结果制成表格并进行统计分析。所有统计分析的显著性水平为p0.05)。运动阻滞时间I组为142.227.77 min, II组为120.623.51 min (p < 0.05)。两组患者的平均疼痛评分具有可比性。结论:布比卡因和罗哌卡因的术后疼痛缓解时间几乎相同，但与布比卡因相比，罗哌卡因的运动阻断作用更小，使其成为日托手术的合适药物，特别是在低龄儿童中，安全裕度更高。
{"title":"A comparison between 0.25% bupivacaine and 0.25% ropivacaine in caudal anaesthesia in paediatric patients undergoing lower abdominal surgeries","authors":"Darshana Kumbhre, R. Jain","doi":"10.7439/IJBR.V8I11.4490","DOIUrl":"https://doi.org/10.7439/IJBR.V8I11.4490","url":null,"abstract":"Aims and Objectives: The present study was undertaken to compare the onset time, duration of action of sensory and motor blockade and postoperative pain relief between 0.25% bupivacaine and 0.25% ropivacaine in caudal block for children undergoing lower abdominal surgeries. Method: In a double blind study, 50 patients of (age 2-8 years) ASA grade I and II were randomly allocated in two equal groups to received 0.75ml/ kg of either 0.25% bupivacaine (Group I) or 0.25% ropivacaine (Group II) via caudal epidural route. Caudal block was performed in all patients after induction of anesthesia with sevoflurane and oxygen. All the results were tabulated and analyzed statistically. For all statistical analysis, the level of significance was P 0.05). The duration of motor block in group I was 142.227.77 minutes while in group II it was 120.623.51 minutes (p 0.05). The mean pain score of patients in both groups were comparable. Conclusion: Bupivacaine and Ropivacaine provides almost similar duration of pain relief postoperatively but ropivacaine provides less motor blockade as compared to bupivacaine, making it a suitable agent for day care surgery with increase safety margin particularly in younger children.","PeriodicalId":13909,"journal":{"name":"International journal of biomedical research","volume":"11 1","pages":"641-645"},"PeriodicalIF":0.0,"publicationDate":"2017-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84494614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Hypertension is a chronic disease which over the years can predispose to stroke, heart failure and chronic kidney disease. So, longer hypertension is present more adverse events are observed. This makes it important to diagnose and control hypertension at an early stage in life. Like most developing countries data on hypertension among young especially medical students are scarce in India. We aimed to determine the prevalence and risk factors of hypertension among young medical students of MGIMS Sevagram. Methods: This cross-sectional study was conducted between August, 2010 and March 2013 in MGIMS Sevagram, a rural based teaching hospital in Wardha District of Maharashtra state of India. Total of 765 students, aged 17-35 years, were studied and their data using a WHO STEPS questionnaire,which included socio-demographic characteristics and risk factors of hypertension, were collected. Blood pressure and anthropometric measurements for obesity were performed using standardized protocols. Blood samples for fasting lipid profile were collected. Statistical analysis was done using STATA 13 software. Results: The prevalence of hypertension was found to be 3.53% and 32.16% students had prehypertension. 41.12% of those already on treatment for hypertension had uncontrolled hypertension. After multivariate logistic regression analysis hypertension risk was significantly higher among alcoholics {OR-3.47 (95% CI 1.91-11.23)}, those with positive family history of hypertension {OR-3.47(95% CI 1.91-11.23 )} those with abnormal waist circumference{OR-4.64 (95% CI 1.44-14.94)} and abnormal waist hip ratio{OR-3.64(95% CI 1.33-10.21)}. Conclusion: This study has found a significant burden of hypertension and prehypertension among young medical students. Despite having adequate knowledge and access to management, large proportion of hypertensive medical students didnt have adequate blood pressure control.
背景:高血压是一种慢性疾病，多年来可导致中风、心力衰竭和慢性肾脏疾病。因此，高血压存在的时间越长，观察到的不良事件就越多。这使得在生命早期诊断和控制高血压变得非常重要。与大多数发展中国家一样，印度关于年轻人特别是医科学生高血压的数据很少。我们的目的是确定MGIMS Sevagram年轻医学生中高血压的患病率和危险因素。方法:本横断面研究于2010年8月至2013年3月在印度马哈拉施特拉邦瓦尔达区农村教学医院MGIMS Sevagram进行。共对765名年龄在17-35岁之间的学生进行了研究，并使用世卫组织STEPS问卷收集了他们的数据，其中包括社会人口统计学特征和高血压危险因素。采用标准化方案进行血压和肥胖人体测量。采集空腹血脂血样。采用STATA 13软件进行统计分析。结果:高三学生高血压患病率为3.53%，高血压前期患病率为32.16%。已接受高血压治疗的患者中，高血压未得到控制的占41.12%。经多因素logistic回归分析，高血压风险显著高于酗酒者(or = 3.47(95% CI 1.91 ~ 11.23))、有高血压家族史者(or = 3.47(95% CI 1.91 ~ 11.23))、腰围异常者(or = 4.64 (95% CI 1.44 ~ 14.94)、腰臀比异常者(or = 3.64(95% CI 1.33 ~ 10.21))。结论:本研究发现年轻医学生高血压及高血压前期负担显著。尽管有足够的知识和管理机会，但很大一部分高血压医学生没有适当的血压控制。
{"title":"Prevalence and risk factors of hypertension among young medical students: An observational study","authors":"T. Rao, J. Jain, Richa Chaudhary","doi":"10.7439/IJBR.V8I11.4467","DOIUrl":"https://doi.org/10.7439/IJBR.V8I11.4467","url":null,"abstract":"Background: Hypertension is a chronic disease which over the years can predispose to stroke, heart failure and chronic kidney disease. So, longer hypertension is present more adverse events are observed. This makes it important to diagnose and control hypertension at an early stage in life. Like most developing countries data on hypertension among young especially medical students are scarce in India. We aimed to determine the prevalence and risk factors of hypertension among young medical students of MGIMS Sevagram. Methods: This cross-sectional study was conducted between August, 2010 and March 2013 in MGIMS Sevagram, a rural based teaching hospital in Wardha District of Maharashtra state of India. Total of 765 students, aged 17-35 years, were studied and their data using a WHO STEPS questionnaire,which included socio-demographic characteristics and risk factors of hypertension, were collected. Blood pressure and anthropometric measurements for obesity were performed using standardized protocols. Blood samples for fasting lipid profile were collected. Statistical analysis was done using STATA 13 software. Results: The prevalence of hypertension was found to be 3.53% and 32.16% students had prehypertension. 41.12% of those already on treatment for hypertension had uncontrolled hypertension. After multivariate logistic regression analysis hypertension risk was significantly higher among alcoholics {OR-3.47 (95% CI 1.91-11.23)}, those with positive family history of hypertension {OR-3.47(95% CI 1.91-11.23 )} those with abnormal waist circumference{OR-4.64 (95% CI 1.44-14.94)} and abnormal waist hip ratio{OR-3.64(95% CI 1.33-10.21)}. Conclusion: This study has found a significant burden of hypertension and prehypertension among young medical students. Despite having adequate knowledge and access to management, large proportion of hypertensive medical students didnt have adequate blood pressure control.","PeriodicalId":13909,"journal":{"name":"International journal of biomedical research","volume":"1 1","pages":"609-613"},"PeriodicalIF":0.0,"publicationDate":"2017-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76016762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To study the effects of once monthly regimen of Ibandronate on bone marrow density, severity of osteoporosis and quality of life in postmenopausal osteoporotic leprosy patients. Materials and Methods: Out of 204 eligible participants, written consent was given by 200 participants who were hence enrolled for the study. These 200 patients with postmenopausal osteoporotic leprosy were administered with Ibandronate tablet (150mg) as once monthly from October 2010 to October 2011. Patients were analyzed for BMD, severity of osteoporosis and quality of life index. Results: The percentage change in the hip BMD at first follow up was increased by 8.83%. and with second follow up it was increased by 14.51%. A total of 4 patients were in Singhs Index Grade I, 128 patients in Grade II and 60 patients in Grade III severity at the baseline screening. No study dropouts were found for entire 1 year of treatment duration, that is 100% adherence were observed in subjects undergoing treatment. Conclusion: Monthly regimen of Ibandronate confirmed having better tolerability and adherence in postmenopausal osteoporotic leprosy patients. The present study was grounded on the assumption that osteoporotic postmenopausal leprosy patients often experience low levels of quality of life. This was substantiated by the findings, where majority of females in showed improvement in their QOL, with reference to physical activity and pain, limitations to daily activities, change in emotional status and general health status.
{"title":"Management of post-menopausal osteoporosis in leprosy patients using one-monthly oral Ibandronate administration","authors":"S. Nagpure, R. Kale, S. Pathak, Satyavan Patel","doi":"10.7439/IJBR.V8I11.4468","DOIUrl":"https://doi.org/10.7439/IJBR.V8I11.4468","url":null,"abstract":"Objective: To study the effects of once monthly regimen of Ibandronate on bone marrow density, severity of osteoporosis and quality of life in postmenopausal osteoporotic leprosy patients. Materials and Methods: Out of 204 eligible participants, written consent was given by 200 participants who were hence enrolled for the study. These 200 patients with postmenopausal osteoporotic leprosy were administered with Ibandronate tablet (150mg) as once monthly from October 2010 to October 2011. Patients were analyzed for BMD, severity of osteoporosis and quality of life index. Results: The percentage change in the hip BMD at first follow up was increased by 8.83%. and with second follow up it was increased by 14.51%. A total of 4 patients were in Singhs Index Grade I, 128 patients in Grade II and 60 patients in Grade III severity at the baseline screening. No study dropouts were found for entire 1 year of treatment duration, that is 100% adherence were observed in subjects undergoing treatment. Conclusion: Monthly regimen of Ibandronate confirmed having better tolerability and adherence in postmenopausal osteoporotic leprosy patients. The present study was grounded on the assumption that osteoporotic postmenopausal leprosy patients often experience low levels of quality of life. This was substantiated by the findings, where majority of females in showed improvement in their QOL, with reference to physical activity and pain, limitations to daily activities, change in emotional status and general health status.","PeriodicalId":13909,"journal":{"name":"International journal of biomedical research","volume":"170 1","pages":"623-629"},"PeriodicalIF":0.0,"publicationDate":"2017-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74871569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Nitric oxide (NO) is an endothelium derived vasodilator. NO regulates renal function through modulation of vascular tone. With the progressive development of renal insufficiency, it remains unclear whether endogenous NO production is increased or decreased in the kidney. Aim: This study was carried out to evaluate NO levels and its correlation to routine parameters of renal dysfunction in patients of chronic renal failure (CRF) on maintenance hemodialysis (MHD) in comparison to healthy controls. Material and Methods: 30 CRF patients on MHD with serum creatinine levels >2.5 mg/dl were included in the study along with 30 healthy controls. Serum NO was estimated by spectrophotometric method using cadmium reduction. Routine renal function tests; blood urea nitrogen (BUN) and creatinine were performed by standard clinical chemistry procedures. The between-group differences and between-variable correlations were studied by the independent sample t-test and Pearson correlation analyses, respectively. The receiver operating characteristic curve (ROC) analysis was performed to obtain the sensitivity, specificity and area under curve (AUC) values for serum NO. Results: The serum NO levels were found to be significantly increased (p 0.01) in CRF on MHD (96.5 26.22 ?mol/l) as compared to the controls (40.57 13.36 ?mol/l). NO output correlated with serum creatinine (r=0.615, p 0.01) and BUN (r=0.584 ,p= 0.01) in the CRF group. The ROC analysis on serum NO discriminated between CRF patients and controls with good sensitivity (93.3%), specificity (96.1%) and AUC (0.95) results at a cut-off value of 72.5 mol/L. Conclusions: Our study findings of increased serum NO level and its significant positive correlations with BUN and creatinine in CRF patients on MHD suggests an altered endothelial function in CRF patients on MHD. This increase in serum NO has been found to be useful in discriminating patients from controls.
{"title":"Serum nitric oxide levels in chronic renal failure patients on maintenance hemodialysis","authors":"Mohammed Mounuddin, B. Laxmikanth","doi":"10.7439/IJBR.V8I10.4444","DOIUrl":"https://doi.org/10.7439/IJBR.V8I10.4444","url":null,"abstract":"Background: Nitric oxide (NO) is an endothelium derived vasodilator. NO regulates renal function through modulation of vascular tone. With the progressive development of renal insufficiency, it remains unclear whether endogenous NO production is increased or decreased in the kidney. Aim: This study was carried out to evaluate NO levels and its correlation to routine parameters of renal dysfunction in patients of chronic renal failure (CRF) on maintenance hemodialysis (MHD) in comparison to healthy controls. Material and Methods: 30 CRF patients on MHD with serum creatinine levels >2.5 mg/dl were included in the study along with 30 healthy controls. Serum NO was estimated by spectrophotometric method using cadmium reduction. Routine renal function tests; blood urea nitrogen (BUN) and creatinine were performed by standard clinical chemistry procedures. The between-group differences and between-variable correlations were studied by the independent sample t-test and Pearson correlation analyses, respectively. The receiver operating characteristic curve (ROC) analysis was performed to obtain the sensitivity, specificity and area under curve (AUC) values for serum NO. Results: The serum NO levels were found to be significantly increased (p 0.01) in CRF on MHD (96.5 26.22 ?mol/l) as compared to the controls (40.57 13.36 ?mol/l). NO output correlated with serum creatinine (r=0.615, p 0.01) and BUN (r=0.584 ,p= 0.01) in the CRF group. The ROC analysis on serum NO discriminated between CRF patients and controls with good sensitivity (93.3%), specificity (96.1%) and AUC (0.95) results at a cut-off value of 72.5 mol/L. Conclusions: Our study findings of increased serum NO level and its significant positive correlations with BUN and creatinine in CRF patients on MHD suggests an altered endothelial function in CRF patients on MHD. This increase in serum NO has been found to be useful in discriminating patients from controls.","PeriodicalId":13909,"journal":{"name":"International journal of biomedical research","volume":"84 1","pages":"576-579"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86204528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anogenital warts are caused by the Human Papilloma Virus (HPV).They are usually more common in Human Immunodeficiency Virus(HIV) infected people than uninfected people and are often very difficult to treat. The authors report a case of recurrent florid vulval warts in an HIV positive patient to illustrate such difficulties in management with the limitations of practice in a developing country.
{"title":"Recurrent florid vulval warts in a human immunodeficiciency virus reactive patient: excision","authors":"I. Shambe, C. Obu","doi":"10.7439/IJBR.V8I10.4383","DOIUrl":"https://doi.org/10.7439/IJBR.V8I10.4383","url":null,"abstract":"Anogenital warts are caused by the Human Papilloma Virus (HPV).They are usually more common in Human Immunodeficiency Virus(HIV) infected people than uninfected people and are often very difficult to treat. The authors report a case of recurrent florid vulval warts in an HIV positive patient to illustrate such difficulties in management with the limitations of practice in a developing country.","PeriodicalId":13909,"journal":{"name":"International journal of biomedical research","volume":"9 1","pages":"595-597"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81895595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：